term name p.value Adjusted.p.value fold_change gene_coverage subcluster cluster subset_cluster 2-OXOBUTANOATE DEGRADATION%HUMANCYC%PWY-5130 2-OXOBUTANOATE DEGRADATION 2.16138830100878e-05 0.0071244761872002 10.2850009726996 0.714285714285714 1.2 1 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.000338178211187015 0.0424655210904837 5.39962551066727 0.375 1.2 1 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00140166397667427 0.09831627747644 5.14250048634978 0.357142857142857 1.2 1 2 SUPERPATHWAY OF METHIONINE DEGRADATION%HUMANCYC%PWY-5328 SUPERPATHWAY OF METHIONINE DEGRADATION 0.000493987729331867 0.050101755471082 5.08200048062802 0.352941176470588 1.2 1 2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-ALPHA SIGNALING PATHWAY 0.00130697991646728 0.09831627747644 4.31970040853382 0.3 1.2 1 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00367840678249935 0.140579111383345 4.23500040052335 0.294117647058824 1.2 1 2 GLYOXYLATE AND DICARBOXYLATE METABOLISM%KEGG%HSA00630 GLYOXYLATE AND DICARBOXYLATE METABOLISM 0.00482378796946651 0.163081139429272 3.99972260049428 0.277777777777778 1.2 1 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00482378796946651 0.163081139429272 3.99972260049428 0.277777777777778 1.2 1 2 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION%KEGG%HSA00280 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION 6.99140712012878e-05 0.015363617146483 3.68346546464124 0.255813953488372 1.2 1 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00123534941876615 0.0958122475672452 3.38800032041868 0.235294117647059 1.2 1 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00123534941876615 0.0958122475672452 3.38800032041868 0.235294117647059 1.2 1 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00318345551087104 0.12835578005189 3.25138740427277 0.225806451612903 1.2 1 2 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY 0.0173104549511504 0.398575021982527 2.99979195037071 0.208333333333333 1.2 1 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0173104549511504 0.398575021982527 2.99979195037071 0.208333333333333 1.2 1 2 PROPANOATE METABOLISM%KEGG%HSA00640 PROPANOATE METABOLISM 0.0097004484998301 0.275054652624215 2.97910373002332 0.206896551724138 1.2 1 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00549340957815385 0.178841000711009 2.96450028036635 0.205882352941176 1.2 1 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 9.7372514699894e-06 0.00366816173233744 2.87980027235588 0.2 1.2 1 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0114733451004495 0.315158448227973 2.87980027235588 0.2 1.2 1 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0205091312650553 0.430573090596212 2.87980027235588 0.2 1.2 1 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.29940277309738e-05 0.00966725012517534 2.84631422267732 0.197674418604651 1.2 1 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.49153756838293e-05 0.0118441845678258 2.78162526307102 0.193181818181818 1.2 1 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00290442997204693 0.119671591191996 2.7572555799152 0.191489361702128 1.2 1 2 RNA DEGRADATION%KEGG%HSA03018 RNA DEGRADATION 0.000442850857784609 0.0467119084791206 2.7128553290309 0.188405797101449 1.2 1 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.54473430954806e-06 0.00239689287485565 2.67078251065263 0.185483870967742 1.2 1 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.54473430954806e-06 0.00239689287485565 2.67078251065263 0.185483870967742 1.2 1 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.54473430954806e-06 0.00239689287485565 2.67078251065263 0.185483870967742 1.2 1 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.028005791157614 0.476459814726633 2.66648173366285 0.185185185185185 1.2 1 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00013705335521786 0.0240939798472998 2.64809220446518 0.183908045977011 1.2 1 2 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY 0.0181401298496663 0.405385783165848 2.61800024759625 0.181818181818182 1.2 1 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0323262827483931 0.510445554536004 2.57125024317489 0.178571428571429 1.2 1 2 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA 0.020850141336419 0.430573090596212 2.54100024031401 0.176470588235294 1.2 1 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.35573382773642e-05 0.0152364273670372 2.53315764697971 0.175925925925926 1.2 1 2 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 INTERNALIZATION OF ERBB1 0.0238214230670568 0.430573090596212 2.4684002334479 0.171428571428571 1.2 1 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0238214230670568 0.430573090596212 2.4684002334479 0.171428571428571 1.2 1 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0238214230670568 0.430573090596212 2.4684002334479 0.171428571428571 1.2 1 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0238214230670568 0.430573090596212 2.4684002334479 0.171428571428571 1.2 1 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0238214230670568 0.430573090596212 2.4684002334479 0.171428571428571 1.2 1 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0238214230670568 0.430573090596212 2.4684002334479 0.171428571428571 1.2 1 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00114660084432351 0.0944870758275343 2.46298707504121 0.171052631578947 1.2 1 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0154726504531838 0.374324580229776 2.45836608615746 0.170731707317073 1.2 1 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.0101245470568636 0.284025857329247 2.45089384881351 0.170212765957447 1.2 1 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.000390856794977023 0.0448125812328004 2.42509496619442 0.168421052631579 1.2 1 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.000390856794977023 0.0448125812328004 2.42509496619442 0.168421052631579 1.2 1 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00219971951881303 0.09831627747644 2.39983356029657 0.166666666666667 1.2 1 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0270631879674258 0.463413160195466 2.39983356029657 0.166666666666667 1.2 1 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0421533288401226 0.587981837894292 2.39983356029657 0.166666666666667 1.2 1 2 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY 0.0175549505020249 0.398575021982527 2.39983356029657 0.166666666666667 1.2 1 2 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 SIGNALING EVENTS 0.0175549505020249 0.398575021982527 2.39983356029657 0.166666666666667 1.2 1 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0175549505020249 0.398575021982527 2.39983356029657 0.166666666666667 1.2 1 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00562297376631987 0.18082660758275 2.36049202652121 0.163934426229508 1.2 1 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00851409257581269 0.246721561784814 2.35620022283663 0.163636363636364 1.2 1 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.000283419038537923 0.0393355791907633 2.33497319380206 0.162162162162162 1.2 1 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0305837526477326 0.501283046247138 2.33497319380206 0.162162162162162 1.2 1 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000626765410003912 0.0590278709350113 2.32711133119667 0.161616161616162 1.2 1 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0145668304739228 0.358997494950788 2.3038402178847 0.16 1.2 1 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00470049815048082 0.163081139429272 2.29549297071845 0.159420289855072 1.2 1 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.022296026389698 0.430573090596212 2.29075021664672 0.159090909090909 1.2 1 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.022296026389698 0.430573090596212 2.29075021664672 0.159090909090909 1.2 1 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00349822695528525 0.137683947478913 2.27352653080727 0.157894736842105 1.2 1 2 UBIQUITIN MEDIATED PROTEOLYSIS%KEGG%HSA04120 UBIQUITIN MEDIATED PROTEOLYSIS 0.00022406339306163 0.0347561863237364 2.24984396277803 0.15625 1.2 1 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00194361643612098 0.09831627747644 2.23984465627679 0.155555555555556 1.2 1 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.0249697615329988 0.438968407750119 2.23984465627679 0.155555555555556 1.2 1 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0249697615329988 0.438968407750119 2.23984465627679 0.155555555555556 1.2 1 2 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION 0.0043473236454915 0.154917465583258 2.21523097873529 0.153846153846154 1.2 1 2 RIBOSOME BIOGENESIS IN EUKARYOTES%KEGG%HSA03008 RIBOSOME BIOGENESIS IN EUKARYOTES 0.00883316061941906 0.25318526688487 2.21523097873529 0.153846153846154 1.2 1 2 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 UBIQUITIN PROTEASOME PATHWAY 0.0384898053745841 0.545673593528317 2.21523097873529 0.153846153846154 1.2 1 2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 CADHERIN SIGNALING PATHWAY 0.000810437820354769 0.0736939493888113 2.20525246081306 0.153153153153153 1.2 1 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0599258438157877 0.690063101057783 2.18166687299688 0.151515151515152 1.2 1 2 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK 0.0148311881687451 0.362128177786861 2.15985020426691 0.15 1.2 1 2 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY 0.0428870852081271 0.587981837894292 2.15985020426691 0.15 1.2 1 2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FOXO FAMILY SIGNALING 0.030957675424911 0.501283046247138 2.14453211771182 0.148936170212766 1.2 1 2 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) SIGNALING PATHWAY 0.0666630338984375 0.690608616713575 2.11750020026167 0.147058823529412 1.2 1 2 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY REGULATION OF RAC1 ACTIVITY 0.0666630338984375 0.690608616713575 2.11750020026167 0.147058823529412 1.2 1 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0666630338984375 0.690608616713575 2.11750020026167 0.147058823529412 1.2 1 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.0132881369733518 0.336930934603162 2.08681179156223 0.144927536231884 1.2 1 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00321254512075265 0.12835578005189 2.05700019453991 0.142857142857143 1.2 1 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0378390500710796 0.545673593528317 2.05700019453991 0.142857142857143 1.2 1 2 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY INSULIN PATHWAY 0.0525919946101327 0.647780442502216 2.05700019453991 0.142857142857143 1.2 1 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0525919946101327 0.647780442502216 2.05700019453991 0.142857142857143 1.2 1 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0525919946101327 0.647780442502216 2.05700019453991 0.142857142857143 1.2 1 2 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L SIGNALING 0.0738033023703342 0.693648007891197 2.05700019453991 0.142857142857143 1.2 1 2 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ERBB4 SIGNALING EVENTS 0.0738033023703342 0.693648007891197 2.05700019453991 0.142857142857143 1.2 1 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0738033023703342 0.693648007891197 2.05700019453991 0.142857142857143 1.2 1 2 SYSTEMIC LUPUS ERYTHEMATOSUS%KEGG%HSA05322 SYSTEMIC LUPUS ERYTHEMATOSUS 0.0047497509465713 0.163081139429272 2.03622241479709 0.141414141414141 1.2 1 2 NUCLEOTIDE EXCISION REPAIR%KEGG%HSA03420 NUCLEOTIDE EXCISION REPAIR 0.0579052618439445 0.684560109761743 2.0091629807134 0.13953488372093 1.2 1 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.0176017615280686 0.398575021982527 1.99986130024714 0.138888888888889 1.2 1 2 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY 0.0813420304998356 0.694171308828694 1.99986130024714 0.138888888888889 1.2 1 2 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING AURORA B SIGNALING 0.0813420304998356 0.694171308828694 1.99986130024714 0.138888888888889 1.2 1 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.0192461563697788 0.426488355858039 1.97246593996978 0.136986301369863 1.2 1 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0361405484778839 0.542458556402397 1.95240696430907 0.135593220338983 1.2 1 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0361405484778839 0.542458556402397 1.95240696430907 0.135593220338983 1.2 1 2 FAS%IOB%FAS FAS 0.00545980573197398 0.178841000711009 1.94581099483505 0.135135135135135 1.2 1 2 TYROSINE METABOLISM%KEGG%HSA00350 TYROSINE METABOLISM 0.0892730114142267 0.719917220487204 1.94581099483505 0.135135135135135 1.2 1 2 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY 0.0892730114142267 0.719917220487204 1.94581099483505 0.135135135135135 1.2 1 2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR SIGNALING PATHWAY 0.0892730114142267 0.719917220487204 1.94581099483505 0.135135135135135 1.2 1 2 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE 0.0892730114142267 0.719917220487204 1.94581099483505 0.135135135135135 1.2 1 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0892730114142267 0.719917220487204 1.94581099483505 0.135135135135135 1.2 1 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0892730114142267 0.719917220487204 1.94581099483505 0.135135135135135 1.2 1 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.28651227505479e-09 1.13035328693195e-05 1.94359143856718 0.134980988593156 1.2 1 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0499205851833563 0.634389591815661 1.93832710639338 0.134615384615385 1.2 1 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 0.000125414376054712 0.0236226935468769 1.93708538499274 0.134529147982063 1.2 1 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0287070737310231 0.485259957876332 1.93419421277634 0.134328358208955 1.2 1 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00356560628950059 0.138272114491368 1.92742537913582 0.133858267716535 1.2 1 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0228679112343011 0.430573090596212 1.91986684823725 0.133333333333333 1.2 1 2 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY 0.0694597744239324 0.690608616713575 1.91986684823725 0.133333333333333 1.2 1 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.0108000513777357 0.299786689295675 1.91007160921563 0.13265306122449 1.2 1 2 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 SIGNALING PATHWAY 0.0544314419816935 0.66145489633975 1.90175489683879 0.132075471698113 1.2 1 2 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-MEDIATED SIGNALING EVENTS 0.0757005102266888 0.693648007891197 1.87813061240601 0.130434782608696 1.2 1 2 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK NOTCH-MEDIATED HES HEY NETWORK 0.0757005102266888 0.693648007891197 1.87813061240601 0.130434782608696 1.2 1 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0126879789494419 0.328021573428219 1.87187017703132 0.13 1.2 1 2 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY P53 PATHWAY 0.0591883598883874 0.684560109761743 1.866537213564 0.12962962962963 1.2 1 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.0591883598883874 0.684560109761743 1.866537213564 0.12962962962963 1.2 1 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.0214739684195932 0.430573090596212 1.86340017623027 0.129411764705882 1.2 1 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.0214739684195932 0.430573090596212 1.86340017623027 0.129411764705882 1.2 1 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.0214739684195932 0.430573090596212 1.86340017623027 0.129411764705882 1.2 1 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0465562717302202 0.620044891679751 1.85793565958444 0.129032258064516 1.2 1 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.106279535656478 0.769295446057735 1.84602581561274 0.128205128205128 1.2 1 2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS CASPASE CASCADE IN APOPTOSIS 0.0822482421489001 0.695155815854646 1.83817038661013 0.127659574468085 1.2 1 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.0822482421489001 0.695155815854646 1.83817038661013 0.127659574468085 1.2 1 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.0822482421489001 0.695155815854646 1.83817038661013 0.127659574468085 1.2 1 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 0.00051664319666832 0.0504588188746059 1.83260017331738 0.127272727272727 1.2 1 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.10742711119277e-06 0.00239689287485565 1.8252255247326 0.126760563380282 1.2 1 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0315452891564921 0.501283046247138 1.82265840022524 0.126582278481013 1.2 1 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.57822942973907e-05 0.0174006084663246 1.81830392623153 0.126279863481229 1.2 1 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 0.00183681766996845 0.09831627747644 1.80971055366626 0.12568306010929 1.2 1 2 AMYOTROPHIC LATERAL SCLEROSIS (ALS)%KEGG%HSA05014 AMYOTROPHIC LATERAL SCLEROSIS (ALS) 0.0891002789451081 0.719917220487204 1.79987517022242 0.125 1.2 1 2 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-BETA RECEPTOR SIGNALING 0.0891002789451081 0.719917220487204 1.79987517022242 0.125 1.2 1 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0891002789451081 0.719917220487204 1.79987517022242 0.125 1.2 1 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.0891002789451081 0.719917220487204 1.79987517022242 0.125 1.2 1 2 BASAL TRANSCRIPTION FACTORS%KEGG%HSA03022 BASAL TRANSCRIPTION FACTORS 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 TRYPTOPHAN METABOLISM%KEGG%HSA00380 TRYPTOPHAN METABOLISM 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 TRANSCRIPTION FACTOR NETWORK 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.115335600006242 0.769295446057735 1.79987517022242 0.125 1.2 1 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.00261889136204301 0.109619309868372 1.78970638394998 0.124293785310734 1.2 1 2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-BETA SIGNALING PATHWAY 0.0118792525579594 0.315890247975833 1.78500016881563 0.12396694214876 1.2 1 2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ERBB1 DOWNSTREAM SIGNALING 0.0231909408746544 0.430573090596212 1.78131975609642 0.123711340206186 1.2 1 2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING P75(NTR)-MEDIATED SIGNALING 0.0587581375793161 0.684560109761743 1.77218478298823 0.123076923076923 1.2 1 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0587581375793161 0.684560109761743 1.77218478298823 0.123076923076923 1.2 1 2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS 0.0749480983981075 0.693648007891197 1.7682984128501 0.12280701754386 1.2 1 2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY COREGULATION OF ANDROGEN RECEPTOR ACTIVITY 0.0749480983981075 0.693648007891197 1.7682984128501 0.12280701754386 1.2 1 2 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE 0.0749480983981075 0.693648007891197 1.7682984128501 0.12280701754386 1.2 1 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 0.000421782688406322 0.0463433728886446 1.76539480297678 0.122605363984674 1.2 1 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.0962530085554379 0.737846463839214 1.76314302389135 0.122448979591837 1.2 1 2 SMALL CELL LUNG CANCER%KEGG%HSA05222 SMALL CELL LUNG CANCER 0.0394132434672212 0.552833633101395 1.75597577582676 0.121951219512195 1.2 1 2 TASTE TRANSDUCTION%KEGG%HSA04742 TASTE TRANSDUCTION 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.12474516909118 0.769295446057735 1.75597577582676 0.121951219512195 1.2 1 2 NOTCH%IOB%NOTCH NOTCH 0.0498148741184669 0.634389591815661 1.75122989535155 0.121621621621622 1.2 1 2 PEROXISOME%KEGG%HSA04146 PEROXISOME 0.0498148741184669 0.634389591815661 1.75122989535155 0.121621621621622 1.2 1 2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 SIGNALING EVENTS 0.0632332479256057 0.690608616713575 1.7453334983975 0.121212121212121 1.2 1 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0632332479256057 0.690608616713575 1.7453334983975 0.121212121212121 1.2 1 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.0679147630706337 0.690608616713575 1.71928374469008 0.119402985074627 1.2 1 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0679147630706337 0.690608616713575 1.71928374469008 0.119402985074627 1.2 1 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0679147630706337 0.690608616713575 1.71928374469008 0.119402985074627 1.2 1 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.0244793801088971 0.438968407750119 1.71731208901956 0.119266055045872 1.2 1 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.00254029582595272 0.108044517629634 1.71416682878326 0.119047619047619 1.2 1 2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T CELL ACTIVATION 0.0866969087741557 0.719917220487204 1.70835609377044 0.11864406779661 1.2 1 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.0385256752037105 0.545673593528317 1.7031076879524 0.118279569892473 1.2 1 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.0261687267705282 0.451025702574398 1.70170016093756 0.118181818181818 1.2 1 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.111441716339223 0.769295446057735 1.69400016020934 0.117647058823529 1.2 1 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.144573273894995 0.797105574690025 1.67430248392784 0.116279069767442 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0298016935270777 0.500554559432508 1.67131265806368 0.116071428571429 1.2 1 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.693648007891197 1.66944943324978 0.115942028985507 1.2 1 2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-MEDIATED SIGNALING EVENTS 0.119466211707379 0.769295446057735 1.66142323405147 0.115384615384615 1.2 1 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.119466211707379 0.769295446057735 1.66142323405147 0.115384615384615 1.2 1 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.119466211707379 0.769295446057735 1.66142323405147 0.115384615384615 1.2 1 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 0.00165967133431272 0.09831627747644 1.66142323405147 0.115384615384615 1.2 1 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 0.0216983242063914 0.430573090596212 1.66142323405147 0.115384615384615 1.2 1 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 0.00513737965713813 0.171484432352826 1.64560015563193 0.114285714285714 1.2 1 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0832041084545608 0.700987968034111 1.64560015563193 0.114285714285714 1.2 1 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.0337876083343541 0.529434913058748 1.64199138336081 0.114035087719298 1.2 1 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.0699251045364143 0.690608616713575 1.64039256020272 0.113924050632911 1.2 1 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0699251045364143 0.690608616713575 1.64039256020272 0.113924050632911 1.2 1 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0699251045364143 0.690608616713575 1.64039256020272 0.113924050632911 1.2 1 2 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY FANCONI ANEMIA PATHWAY 0.154963722765489 0.797105574690025 1.63625015474766 0.113636363636364 1.2 1 2 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B SIGNALING EVENTS MEDIATED BY PTP1B 0.12776852273619 0.770996783650647 1.63007562586182 0.113207547169811 1.2 1 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.0260534057376471 0.451025702574398 1.62394752200519 0.112781954887218 1.2 1 2 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM%KEGG%HSA04070 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 0.0887154598601459 0.719917220487204 1.6224226886512 0.112676056338028 1.2 1 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.0449250385549842 0.601356988170017 1.61484127421825 0.11214953271028 1.2 1 2 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F TRANSCRIPTION FACTOR NETWORK 0.0944331786362971 0.727327804123941 1.59988904019771 0.111111111111111 1.2 1 2 NOTCH%NETPATH%NOTCH NOTCH 0.0944331786362971 0.727327804123941 1.59988904019771 0.111111111111111 1.2 1 2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I SIGNALING EVENTS MEDIATED BY HDAC CLASS I 0.113125755403547 0.769295446057735 1.59988904019771 0.111111111111111 1.2 1 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.113125755403547 0.769295446057735 1.59988904019771 0.111111111111111 1.2 1 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.0792022527704977 0.694171308828694 1.59988904019771 0.111111111111111 1.2 1 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.0792022527704977 0.694171308828694 1.59988904019771 0.111111111111111 1.2 1 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.165651716308184 0.810578198270248 1.59988904019771 0.111111111111111 1.2 1 2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR ANDROGENRECEPTOR 0.0364446970647841 0.542458556402397 1.58729148870009 0.110236220472441 1.2 1 2 CELL CYCLE%KEGG%HSA04110 CELL CYCLE 0.0428808544396722 0.587981837894292 1.58633065850112 0.110169491525424 1.2 1 2 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM%KEGG%HSA04141 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM 0.0252427517307486 0.440828717311152 1.56912194327083 0.108974358974359 1.2 1 2 STARCH AND SUCROSE METABOLISM%KEGG%HSA00500 STARCH AND SUCROSE METABOLISM 0.176621375586415 0.810578198270248 1.56510884367167 0.108695652173913 1.2 1 2 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF RECEPTOR SIGNALING PATHWAY 0.176621375586415 0.810578198270248 1.56510884367167 0.108695652173913 1.2 1 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.176621375586415 0.810578198270248 1.56510884367167 0.108695652173913 1.2 1 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.176621375586415 0.810578198270248 1.56510884367167 0.108695652173913 1.2 1 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.176621375586415 0.810578198270248 1.56510884367167 0.108695652173913 1.2 1 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00744329324164103 0.223045048615993 1.54275014590494 0.107142857142857 1.2 1 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00744329324164103 0.223045048615993 1.54275014590494 0.107142857142857 1.2 1 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00744329324164103 0.223045048615993 1.54275014590494 0.107142857142857 1.2 1 2 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY 0.154263040330656 0.797105574690025 1.54275014590493 0.107142857142857 1.2 1 2 ANGIOGENESIS%PANTHER PATHWAY%P00005 ANGIOGENESIS 0.0386958521007946 0.545673593528317 1.54275014590493 0.107142857142857 1.2 1 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.112809666174481 0.769295446057735 1.5358934785898 0.106666666666667 1.2 1 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.112809666174481 0.769295446057735 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.112809666174481 0.769295446057735 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.112809666174481 0.769295446057735 1.5358934785898 0.106666666666667 1.2 1 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.112809666174481 0.769295446057735 1.5358934785898 0.106666666666667 1.2 1 2 RIBOSOME%KEGG%HSA03010 RIBOSOME 0.187856272424214 0.816107068175703 1.53180865550845 0.106382978723404 1.2 1 2 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS 0.13541300192395 0.777960971837592 1.52716681109781 0.106060606060606 1.2 1 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.099889776306938 0.761298670871085 1.52460014418841 0.105882352941176 1.2 1 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.0747506837500173 0.693648007891197 1.52297129788051 0.105769230769231 1.2 1 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.163594209969779 0.810578198270248 1.51568435387152 0.105263157894737 1.2 1 2 APOPTOSIS%KEGG%HSA04210 APOPTOSIS 0.119335957879384 0.769295446057735 1.51568435387151 0.105263157894737 1.2 1 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.119335957879384 0.769295446057735 1.51568435387151 0.105263157894737 1.2 1 2 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING 0.105503244782316 0.769295446057735 1.50687223553505 0.104651162790698 1.2 1 2 IL1%NETPATH%IL1 IL1 0.143287796456836 0.797105574690025 1.50437327660382 0.104477611940299 1.2 1 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.199339527479924 0.826867162731184 1.49989597518535 0.104166666666667 1.2 1 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.199339527479924 0.826867162731184 1.49989597518535 0.104166666666667 1.2 1 2 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY 0.126058179842482 0.769295446057735 1.49600014148357 0.103896103896104 1.2 1 2 TNFALPHA%IOB%TNFALPHA TNFALPHA 0.0237581592175215 0.430573090596212 1.48955186501166 0.103448275862069 1.2 1 2 CELL ADHESION MOLECULES (CAMS)%KEGG%HSA04514 CELL ADHESION MOLECULES (CAMS) 0.0739469409483513 0.693648007891197 1.48955186501166 0.103448275862069 1.2 1 2 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 TRANSCRIPTION FACTOR NETWORK 0.173159076904491 0.810578198270248 1.48955186501166 0.103448275862069 1.2 1 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.0308420558588097 0.501283046247138 1.48685340148809 0.103260869565217 1.2 1 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.1513761542269 0.797105574690025 1.48225014018317 0.102941176470588 1.2 1 2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 0.0224208747692912 0.430573090596212 1.4802711680334 0.102803738317757 1.2 1 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.132973089480961 0.772322603227103 1.47682065249019 0.102564102564103 1.2 1 2 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS DIRECT P53 EFFECTORS 0.0692862987998385 0.690608616713575 1.47391352522151 0.102362204724409 1.2 1 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0692862987998385 0.690608616713575 1.47391352522151 0.102362204724409 1.2 1 2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 0.0339304134648951 0.529434913058748 1.47086573050435 0.102150537634409 1.2 1 2 AMOEBIASIS%KEGG%HSA05146 AMOEBIASIS 0.10370818493506 0.769295446057735 1.4692858532428 0.102040816326531 1.2 1 2 PNAT%PANTHER PATHWAY%P05912 PNAT 0.211053904630434 0.845819371596434 1.4692858532428 0.102040816326531 1.2 1 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.211053904630434 0.845819371596434 1.4692858532428 0.102040816326531 1.2 1 2 P53 SIGNALING PATHWAY%KEGG%HSA04115 P53 SIGNALING PATHWAY 0.18294724688151 0.810578198270248 1.4643052232318 0.101694915254237 1.2 1 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.18294724688151 0.810578198270248 1.4643052232318 0.101694915254237 1.2 1 2 MELANOMA%KEGG%HSA05218 MELANOMA 0.159671850456479 0.805075850198347 1.46076825409356 0.101449275362319 1.2 1 2 B CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04662 B CELL RECEPTOR SIGNALING PATHWAY 0.159671850456479 0.805075850198347 1.46076825409356 0.101449275362319 1.2 1 2 IL2%NETPATH%IL2 IL2 0.140077087784572 0.787597612980634 1.45812672018019 0.10126582278481 1.2 1 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.140077087784572 0.787597612980634 1.45812672018019 0.10126582278481 1.2 1 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.140077087784572 0.787597612980634 1.45812672018019 0.10126582278481 1.2 1 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.109033491481083 0.769295446057735 1.45444458199792 0.101010101010101 1.2 1 2 TNFALPHA%NETPATH%TNFALPHA TNFALPHA 0.0176842159923988 0.398575021982527 1.45106215273746 0.10077519379845 1.2 1 2 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 WNT SIGNALING PATHWAY 0.023839086547989 0.430573090596212 1.43990013617794 0.1 1.2 1 2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR SIGNALING PATHWAY 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.19294792180706 0.818012330876553 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.147366233628548 0.797105574690025 1.43990013617794 0.1 1.2 1 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.16816826623447 0.810578198270248 1.43990013617794 0.1 1.2 1 2 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM%KEGG%HSA00520 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 0.222981901301094 0.848442171938939 1.43990013617794 0.1 1.2 1 2 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) 0.222981901301094 0.848442171938939 1.43990013617794 0.1 1.2 1 2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY 0.222981901301094 0.848442171938939 1.43990013617794 0.1 1.2 1 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.222981901301094 0.848442171938939 1.43990013617794 0.1 1.2 1 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0943176075000878 0.727327804123941 1.4280001350525 0.0991735537190083 1.2 1 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.154836258928061 0.797105574690025 1.42212359128685 0.0987654320987654 1.2 1 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.154836258928061 0.797105574690025 1.42212359128685 0.0987654320987654 1.2 1 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 0.000182229978757421 0.0300337783739575 1.4196198525698 0.0985915492957746 1.2 1 2 WNT SIGNALING PATHWAY%KEGG%HSA04310 WNT SIGNALING PATHWAY 0.0781241783631723 0.693648007891197 1.4196198525698 0.0985915492957746 1.2 1 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.176858416931662 0.810578198270248 1.4196198525698 0.0985915492957746 1.2 1 2 LONG-TERM POTENTIATION%KEGG%HSA04720 LONG-TERM POTENTIATION 0.203149950441406 0.826867162731184 1.41629521591273 0.0983606557377049 1.2 1 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.203149950441406 0.826867162731184 1.41629521591273 0.0983606557377049 1.2 1 2 GLUTAMATERGIC SYNAPSE%KEGG%HSA04724 GLUTAMATERGIC SYNAPSE 0.111380542363918 0.769295446057735 1.41418763374619 0.0982142857142857 1.2 1 2 NON-SMALL CELL LUNG CANCER%KEGG%HSA05223 NON-SMALL CELL LUNG CANCER 0.235105834449124 0.848442171938939 1.41166680017445 0.0980392156862745 1.2 1 2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B CELL ACTIVATION 0.235105834449124 0.848442171938939 1.41166680017445 0.0980392156862745 1.2 1 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.235105834449124 0.848442171938939 1.41166680017445 0.0980392156862745 1.2 1 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.103333531838934 0.769295446057735 1.4047806206614 0.0975609756097561 1.2 1 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.162482584534536 0.810578198270248 1.4047806206614 0.0975609756097561 1.2 1 2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION 0.185734981055778 0.811244142324938 1.399902910173 0.0972222222222222 1.2 1 2 OXIDATIVE PHOSPHORYLATION%KEGG%HSA00190 OXIDATIVE PHOSPHORYLATION 0.131848464817261 0.772322603227103 1.39796129726013 0.0970873786407767 1.2 1 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.0794123571285654 0.694171308828694 1.39345174468833 0.0967741935483871 1.2 1 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.108026932837802 0.769295446057735 1.39345174468833 0.0967741935483871 1.2 1 2 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR SIGNALING IN NAIVE CD8+ T CELLS 0.247407921974841 0.876248196948057 1.38451936170956 0.0961538461538462 1.2 1 2 AXON GUIDANCE%KEGG%HSA04360 AXON GUIDANCE 0.112843359582703 0.769295446057735 1.38230413073082 0.096 1.2 1 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.194790329382065 0.820546483355441 1.38072615797885 0.0958904109589041 1.2 1 2 ERBB SIGNALING PATHWAY%KEGG%HSA04012 ERBB SIGNALING PATHWAY 0.178284364541424 0.810578198270248 1.37133346302661 0.0952380952380952 1.2 1 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.178284364541424 0.810578198270248 1.37133346302661 0.0952380952380952 1.2 1 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.178284364541424 0.810578198270248 1.37133346302661 0.0952380952380952 1.2 1 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 0.000316014828887011 0.0416665551887524 1.36823089863062 0.0950226244343891 1.2 1 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00604813254418871 0.189868160940781 1.36717790707804 0.094949494949495 1.2 1 2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 ALZHEIMER DISEASE-PRESENILIN PATHWAY 0.163621138719926 0.810578198270248 1.36411591848436 0.0947368421052632 1.2 1 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.204016554204282 0.826867162731184 1.36206769638454 0.0945945945945946 1.2 1 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.204016554204282 0.826867162731184 1.36206769638454 0.0945945945945946 1.2 1 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 0.00375123661803939 0.141314442310998 1.36172692388106 0.0945709281961471 1.2 1 2 REGULATION OF ACTIN CYTOSKELETON%KEGG%HSA04810 REGULATION OF ACTIN CYTOSKELETON 0.0647155742888057 0.690608616713575 1.36109963121298 0.0945273631840796 1.2 1 2 HEDGEHOG SIGNALING PATHWAY%KEGG%HSA04340 HEDGEHOG SIGNALING PATHWAY 0.259870359395535 0.884059537878602 1.35839635488485 0.0943396226415094 1.2 1 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.259870359395535 0.884059537878602 1.35839635488485 0.0943396226415094 1.2 1 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.259870359395535 0.884059537878602 1.35839635488485 0.0943396226415094 1.2 1 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.186429256825526 0.811244142324938 1.35520012816747 0.0941176470588235 1.2 1 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.186429256825526 0.811244142324938 1.35520012816747 0.0941176470588235 1.2 1 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.186429256825526 0.811244142324938 1.35520012816747 0.0941176470588235 1.2 1 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 0.0975546223607078 0.74565663526141 1.34990637766682 0.09375 1.2 1 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.234848389408475 0.848442171938939 1.34990637766682 0.09375 1.2 1 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.234848389408475 0.848442171938939 1.34990637766682 0.09375 1.2 1 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.56398094050616e-06 0.00244536962335246 1.34787294864946 0.0936087798579729 1.2 1 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.157001491063255 0.797105574690025 1.34570106184854 0.0934579439252336 1.2 1 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.157001491063255 0.797105574690025 1.34570106184854 0.0934579439252336 1.2 1 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.133324543552392 0.772322603227103 1.33944198714227 0.0930232558139535 1.2 1 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.194729360624829 0.820546483355441 1.33944198714227 0.0930232558139535 1.2 1 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 0.123153045627531 0.769295446057735 1.33705012645094 0.0928571428571429 1.2 1 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 0.123153045627531 0.769295446057735 1.33705012645094 0.0928571428571429 1.2 1 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.150537557791893 0.797105574690025 1.33100012587877 0.092436974789916 1.2 1 2 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK 0.245738980859888 0.873646413463331 1.32913858724117 0.0923076923076923 1.2 1 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.128077976007732 0.77109959527943 1.32756750144065 0.0921985815602837 1.2 1 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 0.118395683440252 0.769295446057735 1.32622380963758 0.0921052631578947 1.2 1 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.222948785296035 0.848442171938939 1.32622380963758 0.0921052631578947 1.2 1 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.170408428216232 0.810578198270248 1.32100929924582 0.0917431192660551 1.2 1 2 NEUROTROPHIN SIGNALING PATHWAY%KEGG%HSA04722 NEUROTROPHIN SIGNALING PATHWAY 0.156647294650454 0.797105574690025 1.31990845816311 0.0916666666666667 1.2 1 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.193488872670772 0.81898901642508 1.30900012379813 0.0909090909090909 1.2 1 2 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) 0.23263784584139 0.848442171938939 1.30900012379813 0.0909090909090909 1.2 1 2 RANKL%NETPATH%RANKL RANKL 0.23263784584139 0.848442171938939 1.30900012379813 0.0909090909090909 1.2 1 2 RENAL CELL CARCINOMA%KEGG%HSA05211 RENAL CELL CARCINOMA 0.256771578753482 0.882798765544891 1.30900012379813 0.0909090909090909 1.2 1 2 BASAL CELL CARCINOMA%KEGG%HSA05217 BASAL CELL CARCINOMA 0.285205380121938 0.884059537878602 1.30900012379813 0.0909090909090909 1.2 1 2 EGFR1%NETPATH%EGFR1 EGFR1 0.0197077360942399 0.430573090596212 1.30610410582512 0.0907079646017699 1.2 1 2 EGFR1%IOB%EGFR1 EGFR1 0.0217506170765077 0.430573090596212 1.30307704631488 0.0904977375565611 1.2 1 2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 INTEGRIN SIGNALLING PATHWAY 0.132470927195817 0.772322603227103 1.30055496170911 0.0903225806451613 1.2 1 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.20129981732342 0.826867162731184 1.29591012256015 0.09 1.2 1 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.20129981732342 0.826867162731184 1.29591012256015 0.09 1.2 1 2 KITRECEPTOR%IOB%KITRECEPTOR KITRECEPTOR 0.220501164030956 0.848442171938939 1.2942922572386 0.0898876404494382 1.2 1 2 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS BETA1 INTEGRIN CELL SURFACE INTERACTIONS 0.267933917995775 0.884059537878602 1.28946280851756 0.0895522388059701 1.2 1 2 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF SIGNALING PATHWAY 0.19149085701586 0.818012330876553 1.28562512158745 0.0892857142857143 1.2 1 2 INOSITOL PHOSPHATE METABOLISM%KEGG%HSA00562 INOSITOL PHOSPHATE METABOLISM 0.298042864415201 0.901681389844589 1.28562512158745 0.0892857142857143 1.2 1 2 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY 0.298042864415201 0.901681389844589 1.28562512158745 0.0892857142857143 1.2 1 2 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY 0.298042864415201 0.901681389844589 1.28562512158745 0.0892857142857143 1.2 1 2 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 SIGNALING 0.298042864415201 0.901681389844589 1.28562512158745 0.0892857142857143 1.2 1 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.252418226714152 0.876248196948057 1.27586088015767 0.0886075949367089 1.2 1 2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY 0.217302352891322 0.848442171938939 1.27050012015701 0.0882352941176471 1.2 1 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 0.157908748589022 0.799242552839252 1.2599126191557 0.0875 1.2 1 2 PATHWAYS IN CANCER%KEGG%HSA05200 PATHWAYS IN CANCER 0.0745750437491582 0.693648007891197 1.2541065702195 0.0870967741935484 1.2 1 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.290598639789152 0.888989110352662 1.25208707493734 0.0869565217391304 1.2 1 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.290598639789152 0.888989110352662 1.25208707493734 0.0869565217391304 1.2 1 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.290598639789152 0.888989110352662 1.25208707493734 0.0869565217391304 1.2 1 2 OLFACTORY TRANSDUCTION%KEGG%HSA04740 OLFACTORY TRANSDUCTION 0.0859761706712346 0.719743371619193 1.24991331265446 0.0868055555555556 1.2 1 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.233779399728043 0.848442171938939 1.2460674255386 0.0865384615384615 1.2 1 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.148621079203592 0.797105574690025 1.24531903669443 0.0864864864864865 1.2 1 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 0.192583613989939 0.818012330876553 1.24307925425434 0.0863309352517986 1.2 1 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.10684749581752 0.769295446057735 1.24226678415352 0.0862745098039216 1.2 1 2 M-CSF%IOB%M-CSF M-CSF 0.323971708588625 0.916638765859865 1.24129322084305 0.0862068965517241 1.2 1 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.323971708588625 0.916638765859865 1.24129322084305 0.0862068965517241 1.2 1 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.323971708588625 0.916638765859865 1.24129322084305 0.0862068965517241 1.2 1 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.323971708588625 0.916638765859865 1.24129322084305 0.0862068965517241 1.2 1 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.323971708588625 0.916638765859865 1.24129322084305 0.0862068965517241 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.323971708588625 0.916638765859865 1.24129322084305 0.0862068965517241 1.2 1 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 0.0315559293428233 0.501283046247138 1.24036341318699 0.0861423220973783 1.2 1 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.153415024972652 0.797105574690025 1.23862377305629 0.0860215053763441 1.2 1 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.1743125176601 0.810578198270248 1.23672404334302 0.0858895705521472 1.2 1 2 SALIVARY SECRETION%KEGG%HSA04970 SALIVARY SECRETION 0.302076487309904 0.901681389844589 1.23420011672395 0.0857142857142857 1.2 1 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.179962660661316 0.810578198270248 1.22918304307873 0.0853658536585366 1.2 1 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.179962660661316 0.810578198270248 1.22918304307873 0.0853658536585366 1.2 1 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.171335028304256 0.810578198270248 1.22718761606074 0.0852272727272727 1.2 1 2 CHOLINERGIC SYNAPSE%KEGG%HSA04725 CHOLINERGIC SYNAPSE 0.250689498220029 0.876248196948057 1.22255671939636 0.0849056603773585 1.2 1 2 TIGHT JUNCTION%KEGG%HSA04530 TIGHT JUNCTION 0.236804489399719 0.848442171938939 1.22025435269317 0.0847457627118644 1.2 1 2 LYSOSOME%KEGG%HSA04142 LYSOSOME 0.236804489399719 0.848442171938939 1.22025435269317 0.0847457627118644 1.2 1 2 GLIOMA%KEGG%HSA05214 GLIOMA 0.337029529117062 0.925777987793429 1.22025435269317 0.0847457627118644 1.2 1 2 CHRONIC MYELOID LEUKEMIA%KEGG%HSA05220 CHRONIC MYELOID LEUKEMIA 0.313635078421741 0.916638765859865 1.2168170164884 0.0845070422535211 1.2 1 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.313635078421741 0.916638765859865 1.2168170164884 0.0845070422535211 1.2 1 2 CALCIUM SIGNALING PATHWAY%KEGG%HSA04020 CALCIUM SIGNALING PATHWAY 0.191526902734448 0.818012330876553 1.21437360882477 0.0843373493975904 1.2 1 2 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF SIGNALING PATHWAY 0.275385857131689 0.884059537878602 1.21254748309721 0.0842105263157895 1.2 1 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 0.0614778903042964 0.690608616713575 1.19991678014828 0.0833333333333333 1.2 1 2 RNA TRANSPORT%KEGG%HSA03013 RNA TRANSPORT 0.238821301101175 0.854507151972589 1.19991678014828 0.0833333333333333 1.2 1 2 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 0.325262360000466 0.916638765859865 1.19991678014828 0.0833333333333333 1.2 1 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 0.214317095708371 0.848442171938939 1.19991678014828 0.0833333333333333 1.2 1 2 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-BETA SIGNALING PATHWAY 0.303795819411198 0.901681389844589 1.19991678014828 0.0833333333333333 1.2 1 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 0.0128842644083237 0.329862186842229 1.19631342645414 0.0830830830830831 1.2 1 2 FOCAL ADHESION%KEGG%HSA04510 FOCAL ADHESION 0.189226859911098 0.818012330876553 1.19369959475891 0.0829015544041451 1.2 1 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.209507037352591 0.842179965699363 1.19281668085746 0.0828402366863905 1.2 1 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.116553240334762 0.769295446057735 1.19255532750934 0.0828220858895705 1.2 1 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 0.220813785334207 0.848442171938939 1.19227399810912 0.0828025477707006 1.2 1 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.260819551190281 0.884059537878602 1.19000011254375 0.0826446280991736 1.2 1 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.260819551190281 0.884059537878602 1.19000011254375 0.0826446280991736 1.2 1 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.157022029423701 0.797105574690025 1.18580011214654 0.0823529411764706 1.2 1 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.215661934712626 0.848442171938939 1.18580011214654 0.0823529411764706 1.2 1 2 FC EPSILON RI SIGNALING PATHWAY%KEGG%HSA04664 FC EPSILON RI SIGNALING PATHWAY 0.336946422443904 0.925777987793429 1.18347956398187 0.0821917808219178 1.2 1 2 COLORECTAL CANCER%KEGG%HSA05210 COLORECTAL CANCER 0.363250884430489 0.961474051387392 1.18024601326061 0.0819672131147541 1.2 1 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.363250884430489 0.961474051387392 1.18024601326061 0.0819672131147541 1.2 1 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.285634708484099 0.884059537878602 1.17810011141831 0.0818181818181818 1.2 1 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 0.234048992593662 0.848442171938939 1.1772768409002 0.0817610062893082 1.2 1 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.324926127294018 0.916638765859865 1.17201173874949 0.0813953488372093 1.2 1 2 TUBERCULOSIS%KEGG%HSA05152 TUBERCULOSIS 0.254422970783841 0.876248196948057 1.16748659690103 0.0810810810810811 1.2 1 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.206322865523424 0.830646406695069 1.16563344357262 0.080952380952381 1.2 1 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.335579018509746 0.923718029029436 1.15854033945351 0.0804597701149425 1.2 1 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.335579018509746 0.923718029029436 1.15854033945351 0.0804597701149425 1.2 1 2 OSTEOCLAST DIFFERENTIATION%KEGG%HSA04380 OSTEOCLAST DIFFERENTIATION 0.303579786177465 0.901681389844589 1.1570626094287 0.0803571428571429 1.2 1 2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK P73 TRANSCRIPTION FACTOR NETWORK 0.360438139761113 0.961474051387392 1.15192010894235 0.08 1.2 1 2 OOCYTE MEIOSIS%KEGG%HSA04114 OOCYTE MEIOSIS 0.323643176421793 0.916638765859865 1.15192010894235 0.08 1.2 1 2 TOLL-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04620 TOLL-LIKE RECEPTOR SIGNALING PATHWAY 0.346278434553052 0.942349052545303 1.14537510832336 0.0795454545454545 1.2 1 2 FC GAMMA R-MEDIATED PHAGOCYTOSIS%KEGG%HSA04666 FC GAMMA R-MEDIATED PHAGOCYTOSIS 0.346278434553052 0.942349052545303 1.14537510832336 0.0795454545454545 1.2 1 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.346278434553052 0.942349052545303 1.14537510832336 0.0795454545454545 1.2 1 2 BILE SECRETION%KEGG%HSA04976 BILE SECRETION 0.389510085880736 0.983848751405652 1.14277788585551 0.0793650793650794 1.2 1 2 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION%KEGG%HSA05120 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 0.389510085880736 0.983848751405652 1.14277788585551 0.0793650793650794 1.2 1 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.389510085880736 0.983848751405652 1.14277788585551 0.0793650793650794 1.2 1 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 0.292907736600167 0.893978821081759 1.13948931639981 0.079136690647482 1.2 1 2 WNT%IOB%WNT WNT 0.321778617270315 0.916638765859865 1.13676326540364 0.0789473684210526 1.2 1 2 MEASLES%KEGG%HSA05162 MEASLES 0.321778617270315 0.916638765859865 1.13676326540364 0.0789473684210526 1.2 1 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.310967002770615 0.912146814578544 1.13377963478578 0.078740157480315 1.2 1 2 GNRH SIGNALING PATHWAY%KEGG%HSA04912 GNRH SIGNALING PATHWAY 0.357015518622012 0.959683917029812 1.13250572508377 0.0786516853932584 1.2 1 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00669835631527809 0.20780665415751 1.13084839963243 0.0785365853658537 1.2 1 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.142648840285959 0.797105574690025 1.1299664745791 0.07847533632287 1.2 1 2 KITRECEPTOR%NETPATH%KITRECEPTOR KITRECEPTOR 0.343372205176341 0.94196301993469 1.12933344013956 0.0784313725490196 1.2 1 2 TSLP%NETPATH%TSLP TSLP 0.291492389535349 0.890689955046019 1.12933344013956 0.0784313725490196 1.2 1 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.245786636332846 0.873646413463331 1.12803236474769 0.0783410138248848 1.2 1 2 WNT%NETPATH%WNT WNT 0.330958728667987 0.916638765859865 1.1268783674436 0.0782608695652174 1.2 1 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.266356072134227 0.884059537878602 1.12492198138902 0.078125 1.2 1 2 T CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04660 T CELL RECEPTOR SIGNALING PATHWAY 0.353299623874773 0.950664396079364 1.11836903780811 0.0776699029126214 1.2 1 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.325228819332751 0.916638765859865 1.10761548936765 0.0769230769230769 1.2 1 2 GM-CSF%IOB%GM-CSF GM-CSF 0.395815108203154 0.993637006887725 1.10761548936765 0.0769230769230769 1.2 1 2 MRNA SURVEILLANCE PATHWAY%KEGG%HSA03015 MRNA SURVEILLANCE PATHWAY 0.395815108203154 0.993637006887725 1.10761548936765 0.0769230769230769 1.2 1 2 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE REGULATION OF TELOMERASE 0.415690178348147 0.99853292579878 1.10761548936765 0.0769230769230769 1.2 1 2 METABOLIC PATHWAYS%KEGG%HSA01100 METABOLIC PATHWAYS 0.0679957403320953 0.690608616713575 1.10548954792932 0.0767754318618042 1.2 1 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 0.301904876031995 0.901681389844589 1.1015629457099 0.0765027322404372 1.2 1 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.32219377880424 0.916638765859865 1.10056061363919 0.0764331210191083 1.2 1 2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY 0.358752583448299 0.961474051387392 1.09822891742385 0.076271186440678 1.2 1 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.281803827527578 0.884059537878602 1.09768171816255 0.0762331838565022 1.2 1 2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF RECEPTOR SIGNALING PATHWAY 0.373245346564252 0.961474051387392 1.09706677042129 0.0761904761904762 1.2 1 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.389366051408393 0.983848751405652 1.09557619057017 0.0760869565217391 1.2 1 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.262152307441331 0.884059537878602 1.09162104186775 0.075812274368231 1.2 1 2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 0.428716293069021 1 1.09083343649844 0.0757575757575758 1.2 1 2 GASTRIC ACID SECRETION%KEGG%HSA04971 GASTRIC ACID SECRETION 0.428716293069021 1 1.09083343649844 0.0757575757575758 1.2 1 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.326542981686216 0.916638765859865 1.08829661455309 0.0755813953488372 1.2 1 2 MELANOGENESIS%KEGG%HSA04916 MELANOGENESIS 0.400167804821678 0.993637006887725 1.08379580142426 0.0752688172043011 1.2 1 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.400167804821678 0.993637006887725 1.08379580142426 0.0752688172043011 1.2 1 2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING REGULATION OF NUCLEAR SMAD2 3 SIGNALING 0.419366784156007 0.99853292579878 1.07992510213345 0.075 1.2 1 2 IL4%NETPATH%IL4 IL4 0.419366784156007 0.99853292579878 1.07992510213345 0.075 1.2 1 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.330273087548395 0.916638765859865 1.0780001019514 0.0748663101604278 1.2 1 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.241883569028437 0.864291289333318 1.07621401930825 0.0747422680412371 1.2 1 2 BACTERIAL INVASION OF EPITHELIAL CELLS%KEGG%HSA05100 BACTERIAL INVASION OF EPITHELIAL CELLS 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 RAS PATHWAY%PANTHER PATHWAY%P04393 RAS PATHWAY 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.410965000156814 0.99853292579878 1.07226605885591 0.074468085106383 1.2 1 2 LEUKOCYTE TRANSENDOTHELIAL MIGRATION%KEGG%HSA04670 LEUKOCYTE TRANSENDOTHELIAL MIGRATION 0.403288755871094 0.99853292579878 1.06659269346514 0.0740740740740741 1.2 1 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.431102100582259 1 1.06659269346514 0.0740740740740741 1.2 1 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.396189958325662 0.993637006887725 1.06222141193455 0.0737704918032787 1.2 1 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 0.315062571778947 0.916638765859865 1.05875010013084 0.0735294117647059 1.2 1 2 VEGF SIGNALING PATHWAY%KEGG%HSA04370 VEGF SIGNALING PATHWAY 0.454576971738899 1 1.05875010013084 0.0735294117647059 1.2 1 2 IL6%NETPATH%IL6 IL6 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.366514265554492 0.961474051387392 1.04992718262975 0.0729166666666667 1.2 1 2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 TRANSCRIPTION FACTOR NETWORK 0.467387778922474 1 1.04340589578112 0.072463768115942 1.2 1 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.454443842393263 1 1.04089166470694 0.072289156626506 1.2 1 2 MAPK SIGNALING PATHWAY%KEGG%HSA04010 MAPK SIGNALING PATHWAY 0.359924437316552 0.961474051387392 1.03672809804812 0.072 1.2 1 2 INFLUENZA A%KEGG%HSA05164 INFLUENZA A 0.425015090012178 0.998910522668568 1.02850009726996 0.0714285714285714 1.2 1 2 SPLICEOSOME%KEGG%HSA03040 SPLICEOSOME 0.443304027723306 1 1.02850009726996 0.0714285714285714 1.2 1 2 PROTEIN DIGESTION AND ABSORPTION%KEGG%HSA04974 PROTEIN DIGESTION AND ABSORPTION 0.48010403212344 1 1.02850009726996 0.0714285714285714 1.2 1 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.48010403212344 1 1.02850009726996 0.0714285714285714 1.2 1 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.19454378897172 0.820546483355441 1.0276365371547 0.0713685978169605 1.2 1 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.403306871406912 0.99853292579878 1.02327928459346 0.0710659898477157 1.2 1 2 BCR%NETPATH%BCR BCR 0.425398755008268 0.998910522668568 1.02186461277144 0.0709677419354839 1.2 1 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.425398755008268 0.998910522668568 1.02186461277144 0.0709677419354839 1.2 1 2 ECM-RECEPTOR INTERACTION%KEGG%HSA04512 ECM-RECEPTOR INTERACTION 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 ADHERENS JUNCTION%KEGG%HSA04520 ADHERENS JUNCTION 0.492715316494781 1 1.014014180407 0.0704225352112676 1.2 1 2 INSULIN SIGNALING PATHWAY%KEGG%HSA04910 INSULIN SIGNALING PATHWAY 0.461764618926294 1 1.0045814903567 0.0697674418604651 1.2 1 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.450624745866419 1 1.00246212012388 0.069620253164557 1.2 1 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 0.388298715878899 0.983848751405652 1.00100009466916 0.0695187165775401 1.2 1 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS)%KEGG%HSA05142 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS) 0.485777691737228 1 0.997950589430255 0.0693069306930693 1.2 1 2 PHAGOSOME%KEGG%HSA04145 PHAGOSOME 0.47105613978599 1 0.996853940430881 0.0692307692307692 1.2 1 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.480314153307555 1 0.989244368366523 0.0687022900763359 1.2 1 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.480314153307555 1 0.989244368366523 0.0687022900763359 1.2 1 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.445754706015033 1 0.988772625701589 0.0686695278969957 1.2 1 2 TCR%NETPATH%TCR TCR 0.444781332689152 1 0.987028319154232 0.0685483870967742 1.2 1 2 TOXOPLASMOSIS%KEGG%HSA05145 TOXOPLASMOSIS 0.492705744876713 1 0.984547101660129 0.0683760683760684 1.2 1 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.475719897326212 1 0.98378270173648 0.0683229813664596 1.2 1 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.489534146184827 1 0.981750092848595 0.0681818181818182 1.2 1 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.511640280960568 1 0.981750092848595 0.0681818181818182 1.2 1 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.484039487253103 1 0.977709969009712 0.0679012345679012 1.2 1 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.522817974623596 1 0.970719192928948 0.0674157303370786 1.2 1 2 HEPATITIS C%KEGG%HSA05160 HEPATITIS C 0.51213176990356 1 0.968000091548194 0.0672268907563025 1.2 1 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.411330731670703 0.99853292579878 0.963405154404769 0.0669077757685353 1.2 1 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.533892006380606 1 0.959933424118626 0.0666666666666667 1.2 1 2 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 HUNTINGTON DISEASE 0.537504942796263 1 0.950877448419394 0.0660377358490566 1.2 1 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.534915004905303 1 0.945919797489157 0.0656934306569343 1.2 1 2 PURINE METABOLISM%KEGG%HSA00230 PURINE METABOLISM 0.538228799865555 1 0.9411112001163 0.065359477124183 1.2 1 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 0.507481651161585 1 0.94052574991405 0.0653188180404355 1.2 1 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.550194300105693 1 0.93652041377427 0.0650406504065041 1.2 1 2 RHEUMATOID ARTHRITIS%KEGG%HSA05323 RHEUMATOID ARTHRITIS 0.56566920111548 1 0.935000088427233 0.0649350649350649 1.2 1 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.55760351006193 1 0.933268606781998 0.0648148148148148 1.2 1 2 PYRIMIDINE METABOLISM%KEGG%HSA00240 PYRIMIDINE METABOLISM 0.566430852333283 1 0.928967829792219 0.0645161290322581 1.2 1 2 NATURAL KILLER CELL MEDIATED CYTOTOXICITY%KEGG%HSA04650 NATURAL KILLER CELL MEDIATED CYTOTOXICITY 0.566430852333283 1 0.928967829792219 0.0645161290322581 1.2 1 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 0.540867375806479 1 0.928967829792219 0.0645161290322581 1.2 1 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.561427510925974 1 0.925650087542961 0.0642857142857143 1.2 1 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.554305685335307 1 0.925237035295061 0.0642570281124498 1.2 1 2 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK GLUCOCORTICOID RECEPTOR REGULATORY NETWORK 0.577303043095776 1 0.923012907806371 0.0641025641025641 1.2 1 2 LEPTIN%NETPATH%LEPTIN LEPTIN 0.587499185030258 1 0.909410612322909 0.0631578947368421 1.2 1 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.587499185030258 1 0.909410612322909 0.0631578947368421 1.2 1 2 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY 0.588513945797851 1 0.905080085597562 0.0628571428571429 1.2 1 2 IL3%NETPATH%IL3 IL3 0.600062893860318 1 0.899937585111212 0.0625 1.2 1 2 HYPERTROPHIC CARDIOMYOPATHY (HCM)%KEGG%HSA05410 HYPERTROPHIC CARDIOMYOPATHY (HCM) 0.611178735523348 1 0.888827244554283 0.0617283950617284 1.2 1 2 GAP JUNCTION%KEGG%HSA04540 GAP JUNCTION 0.611178735523348 1 0.888827244554283 0.0617283950617284 1.2 1 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.611178735523348 1 0.888827244554283 0.0617283950617284 1.2 1 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.619487105176599 1 0.883374316673582 0.0613496932515337 1.2 1 2 TGF-BETA SIGNALING PATHWAY%KEGG%HSA04350 TGF-BETA SIGNALING PATHWAY 0.622112579988318 1 0.877987887913378 0.0609756097560976 1.2 1 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.622112579988318 1 0.877987887913378 0.0609756097560976 1.2 1 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.648129553022647 1 0.874225082679463 0.0607142857142857 1.2 1 2 JAK-STAT SIGNALING PATHWAY%KEGG%HSA04630 JAK-STAT SIGNALING PATHWAY 0.647623229442841 1 0.859641872345038 0.0597014925373134 1.2 1 2 DILATED CARDIOMYOPATHY%KEGG%HSA05414 DILATED CARDIOMYOPATHY 0.653785924835526 1 0.84700008010467 0.0588235294117647 1.2 1 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.66397558374287 1 0.84700008010467 0.0588235294117647 1.2 1 2 ENDOCYTOSIS%KEGG%HSA04144 ENDOCYTOSIS 0.682402980602533 1 0.842494760529645 0.0585106382978723 1.2 1 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.671979340570006 1 0.84081759776814 0.0583941605839416 1.2 1 2 NEUROACTIVE LIGAND-RECEPTOR INTERACTION%KEGG%HSA04080 NEUROACTIVE LIGAND-RECEPTOR INTERACTION 0.707725451085768 1 0.837151241963918 0.0581395348837209 1.2 1 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.682776676652988 1 0.836071046812997 0.0580645161290323 1.2 1 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.685567927354564 1 0.826172209282424 0.0573770491803279 1.2 1 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.711396383086911 1 0.815037812930909 0.0566037735849057 1.2 1 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.711396383086911 1 0.815037812930909 0.0566037735849057 1.2 1 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.71021874393482 1 0.811211344325599 0.0563380281690141 1.2 1 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.726459412085123 1 0.785400074278876 0.0545454545454545 1.2 1 2 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 APOPTOSIS SIGNALING PATHWAY 0.746522162322107 1 0.757842176935758 0.0526315789473684 1.2 1 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.785398513201621 1 0.71995006808897 0.05 1.2 1 2 CHEMOKINE SIGNALING PATHWAY%KEGG%HSA04062 CHEMOKINE SIGNALING PATHWAY 0.960737279410575 1 0.523600049519251 0.0363636363636364 1.2 1 2 CYTOKINE-CYTOKINE RECEPTOR INTERACTION%KEGG%HSA04060 CYTOKINE-CYTOKINE RECEPTOR INTERACTION 0.999009325910904 1 0.324301832472509 0.0225225225225225 1.2 1 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 6.74556438128553e-05 0.000366009326614197 2.32099853157122 1 1.1 1 1 &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 &GAMMA;-GLUTAMYL CYCLE 0.000744632682317526 0.00286238539835469 2.32099853157122 1 1.1 1 1 TNFSF3%IOB%TNFSF3 TNFSF3 1.66413378930022e-07 2.34669561624849e-06 2.32099853157122 1 1.1 1 1 TYROSINE DEGRADATION%HUMANCYC%TYRFUMCAT-PWY TYROSINE DEGRADATION 0.00247377041640824 0.00778440642967606 2.32099853157122 1 1.1 1 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00247377041640824 0.00778440642967606 2.32099853157122 1 1.1 1 1 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.00247377041640824 0.00778440642967606 2.32099853157122 1 1.1 1 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00247377041640824 0.00778440642967606 2.32099853157122 1 1.1 1 1 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 FORWARD SIGNALING 5.5683388389217e-09 1.17469676145892e-07 2.1988407141201 0.947368421052632 1.1 1 1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-CADHERIN SIGNALING IN KERATINOCYTES 5.5683388389217e-09 1.17469676145892e-07 2.1988407141201 0.947368421052632 1.1 1 1 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY 5.19350662735446e-06 4.25299613107355e-05 2.14246018298882 0.923076923076923 1.1 1 1 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY ATYPICAL NF-KAPPAB PATHWAY 5.19350662735446e-06 4.25299613107355e-05 2.14246018298882 0.923076923076923 1.1 1 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 1.5975009513129e-05 0.000107739386409517 2.12758198727362 0.916666666666667 1.1 1 1 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY 4.88171259959497e-05 0.000275303872875584 2.10999866506474 0.909090909090909 1.1 1 1 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY 0.000148025675002942 0.000714915210591134 2.0888986784141 0.9 1.1 1 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.000148025675002942 0.000714915210591134 2.0888986784141 0.9 1.1 1 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000148025675002942 0.000714915210591134 2.0888986784141 0.9 1.1 1 1 TNFSF1%IOB%TNFSF1 TNFSF1 3.10985256139164e-06 2.79598844334772e-05 2.03087371512482 0.875 1.1 1 1 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY 6.92645590747872e-08 1.10697358957705e-06 2.00449873181151 0.863636363636364 1.1 1 1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN) 2.62808812374185e-05 0.00016579589431357 1.98942731277533 0.857142857142857 1.1 1 1 SA_G2_AND_M_PHASES%MSIGDB_C2%SA_G2_AND_M_PHASES SA_G2_AND_M_PHASES 0.00386766404001543 0.0113955643279561 1.98942731277533 0.857142857142857 1.1 1 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00386766404001543 0.0113955643279561 1.98942731277533 0.857142857142857 1.1 1 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00386766404001543 0.0113955643279561 1.98942731277533 0.857142857142857 1.1 1 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00386766404001543 0.0113955643279561 1.98942731277533 0.857142857142857 1.1 1 1 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY 7.52732753848886e-05 0.00039858559676697 1.96392183440642 0.846153846153846 1.1 1 1 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY 7.52732753848886e-05 0.00039858559676697 1.96392183440642 0.846153846153846 1.1 1 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 7.52732753848886e-05 0.00039858559676697 1.96392183440642 0.846153846153846 1.1 1 1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY P38 MAPK SIGNALING PATHWAY 3.65081890414275e-08 6.21110287111254e-07 1.94963876651982 0.84 1.1 1 1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY 0.000213027708410054 0.000983807472990039 1.93416544297602 0.833333333333333 1.1 1 1 GLYCINE BETAINE DEGRADATION%HUMANCYC%PWY-3661-1 GLYCINE BETAINE DEGRADATION 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 CYANOAMINO ACID METABOLISM%KEGG%HSA00460 CYANOAMINO ACID METABOLISM 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF RECEPTOR SIGNALING NETWORK 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY ALTERNATIVE NF-KAPPAB PATHWAY 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 VITAMIN D METABOLISM AND PATHWAY 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0111194590868618 0.027601567686833 1.93416544297602 0.833333333333333 1.1 1 1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY 1.26919547144314e-05 8.80754857419884e-05 1.91141055541159 0.823529411764706 1.1 1 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000594464145534409 0.00241541132784936 1.89899879855827 0.818181818181818 1.1 1 1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY 2.14903855399846e-06 2.0758295483128e-05 1.8789035731767 0.80952380952381 1.1 1 1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY 9.50792441424714e-05 0.000489030703376231 1.85679882525697 0.8 1.1 1 1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY 9.50792441424714e-05 0.000489030703376231 1.85679882525697 0.8 1.1 1 1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY 0.00163137183838142 0.00548016246855007 1.85679882525697 0.8 1.1 1 1 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY 0.00163137183838142 0.00548016246855007 1.85679882525697 0.8 1.1 1 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00163137183838142 0.00548016246855007 1.85679882525697 0.8 1.1 1 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00163137183838142 0.00548016246855007 1.85679882525697 0.8 1.1 1 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00163137183838142 0.00548016246855007 1.85679882525697 0.8 1.1 1 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00163137183838142 0.00548016246855007 1.85679882525697 0.8 1.1 1 1 TNFSF8%IOB%TNFSF8 TNFSF8 1.55706851149137e-05 0.000106926814187571 1.83236726176675 0.789473684210526 1.1 1 1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY CIRCADIAN RHYTHM PATHWAY 0.000254912053925613 0.00114126160645474 1.82364170337739 0.785714285714286 1.1 1 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000254912053925613 0.00114126160645474 1.82364170337739 0.785714285714286 1.1 1 1 BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY 2.59006696626961e-06 2.47464006885976e-05 1.81643363340356 0.782608695652174 1.1 1 1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY CANONICAL NF-KAPPAB PATHWAY 2.59006696626961e-06 2.47464006885976e-05 1.81643363340356 0.782608695652174 1.1 1 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 5.54924338739972e-11 2.48022962924967e-09 1.80522108011095 0.777777777777778 1.1 1 1 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 PATHWAY 4.35623175371495e-07 5.29372494679554e-06 1.80522108011095 0.777777777777778 1.1 1 1 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-PHOSPHOINOSITIDE DEGRADATION 4.11639983328533e-05 0.000245032649218362 1.80522108011095 0.777777777777778 1.1 1 1 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY 4.11639983328533e-05 0.000245032649218362 1.80522108011095 0.777777777777778 1.1 1 1 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY 4.11639983328533e-05 0.000245032649218362 1.80522108011095 0.777777777777778 1.1 1 1 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN DEGRADATION OF BETA CATENIN 4.11639983328533e-05 0.000245032649218362 1.80522108011095 0.777777777777778 1.1 1 1 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY 0.00438730346026337 0.0126704507474448 1.80522108011095 0.777777777777778 1.1 1 1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 CIRCADIAN CLOCK SYSTEM 0.00438730346026337 0.0126704507474448 1.80522108011095 0.777777777777778 1.1 1 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.00438730346026337 0.0126704507474448 1.80522108011095 0.777777777777778 1.1 1 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00438730346026337 0.0126704507474448 1.80522108011095 0.777777777777778 1.1 1 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00438730346026337 0.0126704507474448 1.80522108011095 0.777777777777778 1.1 1 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00438730346026337 0.0126704507474448 1.80522108011095 0.777777777777778 1.1 1 1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION 8.3480286305199e-10 2.62068470222393e-08 1.79877386196769 0.775 1.1 1 1 CIRCADIAN RHYTHM - MAMMAL%KEGG%HSA04710 CIRCADIAN RHYTHM - MAMMAL 6.78346347027097e-06 5.05756762942322e-05 1.79349886530503 0.772727272727273 1.1 1 1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-MEDIATED SIGNALING EVENTS 1.26052396641385e-08 2.42627861272505e-07 1.7904845814978 0.771428571428571 1.1 1 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.13330661039082e-06 1.24522063816691e-05 1.78538348582401 0.769230769230769 1.1 1 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000672209151827271 0.00264847456192349 1.78538348582401 0.769230769230769 1.1 1 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000672209151827271 0.00264847456192349 1.78538348582401 0.769230769230769 1.1 1 1 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY 1.75545594811861e-05 0.000115439833795232 1.76837983357807 0.761904761904762 1.1 1 1 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF RECEPTOR SIGNALING PATHWAY 1.64505562682956e-10 6.02501623326328e-09 1.7659771435868 0.760869565217391 1.1 1 1 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY 2.9175714110883e-06 2.68070934182573e-05 1.76395888399413 0.76 1.1 1 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.9175714110883e-06 2.68070934182573e-05 1.76395888399413 0.76 1.1 1 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.9175714110883e-06 2.68070934182573e-05 1.76395888399413 0.76 1.1 1 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.10612290282921e-07 2.89262817435449e-06 1.74074889867841 0.75 1.1 1 1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY NECTIN ADHESION PATHWAY 1.24499876588138e-06 1.34551710886442e-05 1.74074889867841 0.75 1.1 1 1 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY 7.42560733184157e-06 5.46964428325872e-05 1.74074889867841 0.75 1.1 1 1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-ALPHA SIGNALING PATHWAY 4.48316812782396e-05 0.000258689591970936 1.74074889867841 0.75 1.1 1 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 4.48316812782396e-05 0.000258689591970936 1.74074889867841 0.75 1.1 1 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.48316812782396e-05 0.000258689591970936 1.74074889867841 0.75 1.1 1 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 4.48316812782396e-05 0.000258689591970936 1.74074889867841 0.75 1.1 1 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 4.48316812782396e-05 0.000258689591970936 1.74074889867841 0.75 1.1 1 1 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY 0.000275444411689493 0.00121259918802202 1.74074889867841 0.75 1.1 1 1 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY 0.000275444411689493 0.00121259918802202 1.74074889867841 0.75 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000275444411689493 0.00121259918802202 1.74074889867841 0.75 1.1 1 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000275444411689493 0.00121259918802202 1.74074889867841 0.75 1.1 1 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000275444411689493 0.00121259918802202 1.74074889867841 0.75 1.1 1 1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION 0.00173877345690747 0.00571001943445206 1.74074889867841 0.75 1.1 1 1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY 0.00173877345690747 0.00571001943445206 1.74074889867841 0.75 1.1 1 1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY 0.00173877345690747 0.00571001943445206 1.74074889867841 0.75 1.1 1 1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY 0.00173877345690747 0.00571001943445206 1.74074889867841 0.75 1.1 1 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00173877345690747 0.00571001943445206 1.74074889867841 0.75 1.1 1 1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%HUMANCYC%PWY66-414 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 SUCROSE DEGRADATION%HUMANCYC%PWY66-373 SUCROSE DEGRADATION 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0115081657353027 0.0282560829087459 1.74074889867841 0.75 1.1 1 1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY REGULATION OF RHOA ACTIVITY 2.64798478179742e-09 6.40617969688055e-08 1.72725472116928 0.744186046511628 1.1 1 1 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY 1.54032632354777e-08 2.92218742100394e-07 1.72587070296321 0.743589743589744 1.1 1 1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS ARF6 SIGNALING EVENTS 8.99893324941034e-08 1.37168710859509e-06 1.72417033773862 0.742857142857143 1.1 1 1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 3.12668785330316e-06 2.79598844334772e-05 1.71925817153424 0.740740740740741 1.1 1 1 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY 3.12668785330316e-06 2.79598844334772e-05 1.71925817153424 0.740740740740741 1.1 1 1 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY 3.12668785330316e-06 2.79598844334772e-05 1.71925817153424 0.740740740740741 1.1 1 1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY 0.000112825275343084 0.000562350130146781 1.71020944431563 0.736842105263158 1.1 1 1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION 2.23689256794747e-07 3.00953352126402e-06 1.70661656733178 0.735294117647059 1.1 1 1 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY ARF6 DOWNSTREAM PATHWAY 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000694452280829252 0.00267338783145509 1.70206558981889 0.733333333333333 1.1 1 1 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY 7.76057587012431e-06 5.66887495000493e-05 1.69611431153281 0.730769230769231 1.1 1 1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY 6.89282755932506e-09 1.42003017765158e-07 1.6879989320518 0.727272727272727 1.1 1 1 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY 4.62774821769597e-05 0.000262957983843157 1.6879989320518 0.727272727272727 1.1 1 1 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY 4.62774821769597e-05 0.000262957983843157 1.6879989320518 0.727272727272727 1.1 1 1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL SIGNALING EVENTS MEDIATED BY PRL 4.62774821769597e-05 0.000262957983843157 1.6879989320518 0.727272727272727 1.1 1 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 4.62774821769597e-05 0.000262957983843157 1.6879989320518 0.727272727272727 1.1 1 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.62774821769597e-05 0.000262957983843157 1.6879989320518 0.727272727272727 1.1 1 1 THROMBOPOIETIN%IOB%THROMBOPOIETIN THROMBOPOIETIN 0.00439645901930679 0.0126704507474448 1.6879989320518 0.727272727272727 1.1 1 1 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY 0.00439645901930679 0.0126704507474448 1.6879989320518 0.727272727272727 1.1 1 1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY 0.00439645901930679 0.0126704507474448 1.6879989320518 0.727272727272727 1.1 1 1 BIOCARTA_GLYCOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_GLYCOLYSIS_PATHWAY BIOCARTA_GLYCOLYSIS_PATHWAY 0.00439645901930679 0.0126704507474448 1.6879989320518 0.727272727272727 1.1 1 1 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY 0.00439645901930679 0.0126704507474448 1.6879989320518 0.727272727272727 1.1 1 1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA 5.50613419590408e-07 6.50697449117598e-06 1.6879989320518 0.727272727272727 1.1 1 1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS OSTEOPONTIN-MEDIATED EVENTS 3.22586290506972e-06 2.83979957287683e-05 1.68072307458606 0.724137931034483 1.1 1 1 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR 2.30695986576031e-07 3.08238345105606e-06 1.67627671724588 0.722222222222222 1.1 1 1 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY 0.000279327815065738 0.00122153805692927 1.67627671724588 0.722222222222222 1.1 1 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000279327815065738 0.00122153805692927 1.67627671724588 0.722222222222222 1.1 1 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000279327815065738 0.00122153805692927 1.67627671724588 0.722222222222222 1.1 1 1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM PATHWAY 1.34123613982074e-06 1.42614504060778e-05 1.66821769456681 0.71875 1.1 1 1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING INTEGRIN-LINKED KINASE SIGNALING 4.04579053856184e-08 6.79538194279463e-07 1.65785609397944 0.714285714285714 1.1 1 1 IL-7%NETPATH%IL-7 IL-7 7.8309105718576e-06 5.68873586170482e-05 1.65785609397944 0.714285714285714 1.1 1 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 7.8309105718576e-06 5.68873586170482e-05 1.65785609397944 0.714285714285714 1.1 1 1 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY 0.000113024485770874 0.000562350130146781 1.65785609397944 0.714285714285714 1.1 1 1 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY 0.000113024485770874 0.000562350130146781 1.65785609397944 0.714285714285714 1.1 1 1 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.000113024485770874 0.000562350130146781 1.65785609397944 0.714285714285714 1.1 1 1 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS 0.00171545189658141 0.00567584272432269 1.65785609397944 0.714285714285714 1.1 1 1 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY 0.00171545189658141 0.00567584272432269 1.65785609397944 0.714285714285714 1.1 1 1 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY 0.00171545189658141 0.00567584272432269 1.65785609397944 0.714285714285714 1.1 1 1 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY 0.00171545189658141 0.00567584272432269 1.65785609397944 0.714285714285714 1.1 1 1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING 0.00171545189658141 0.00567584272432269 1.65785609397944 0.714285714285714 1.1 1 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00171545189658141 0.00567584272432269 1.65785609397944 0.714285714285714 1.1 1 1 RETINOATE BIOSYNTHESIS I%HUMANCYC%PWY-6872 RETINOATE BIOSYNTHESIS I 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 2-OXOBUTANOATE DEGRADATION%HUMANCYC%PWY-5130 2-OXOBUTANOATE DEGRADATION 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 PYRUVATE METABOLISM 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0292489467039779 0.0615067563464032 1.65785609397944 0.714285714285714 1.1 1 1 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-BETA SIGNALING PATHWAY 1.74734023829938e-20 3.54441246799651e-18 1.64963531995971 0.710743801652893 1.1 1 1 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF RECEPTOR (ERBB1) SIGNALING PATHWAY 3.23071623763007e-06 2.83979957287683e-05 1.64716024821183 0.709677419354839 1.1 1 1 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 1.23557240992344e-12 8.80595795937328e-11 1.64404062652961 0.708333333333333 1.1 1 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 7.0952293210899e-09 1.45039687749722e-07 1.64404062652961 0.708333333333333 1.1 1 1 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY 4.59598229881838e-05 0.000262957983843157 1.64404062652961 0.708333333333333 1.1 1 1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK GLYPICAN 1 NETWORK 4.59598229881838e-05 0.000262957983843157 1.64404062652961 0.708333333333333 1.1 1 1 ENDOMETRIAL CANCER%KEGG%HSA05213 ENDOMETRIAL CANCER 2.97202885729769e-09 6.94851705740546e-08 1.63835190463851 0.705882352941177 1.1 1 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.3352314103e-06 1.42550818986279e-05 1.63835190463851 0.705882352941177 1.1 1 1 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 AXON GUIDANCE MEDIATED BY SEMAPHORINS 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.000678941525923503 0.00264847456192349 1.63835190463851 0.705882352941177 1.1 1 1 ADHERENS JUNCTION%KEGG%HSA04520 ADHERENS JUNCTION 2.92637531712622e-12 1.83734564553854e-10 1.63450600814875 0.704225352112676 1.1 1 1 CHRONIC MYELOID LEUKEMIA%KEGG%HSA05220 CHRONIC MYELOID LEUKEMIA 2.92637531712622e-12 1.83734564553854e-10 1.63450600814875 0.704225352112676 1.1 1 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.87660599100745e-05 0.000122490346492244 1.63329526295752 0.703703703703704 1.1 1 1 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP SIGNALING EVENTS MEDIATED BY TCPTP 5.52735034517793e-07 6.50697449117598e-06 1.6309719411041 0.702702702702703 1.1 1 1 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY 7.68901010122837e-06 5.63219989914978e-05 1.62469897209985 0.7 1.1 1 1 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY 0.000271476994827721 0.00120722569200793 1.62469897209985 0.7 1.1 1 1 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION%HUMANCYC%PWY-7434 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 ST_G_ALPHA_S_PATHWAY%MSIGDB_C2%ST_G_ALPHA_S_PATHWAY ST_G_ALPHA_S_PATHWAY 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0108178105779879 0.0271741559358727 1.62469897209985 0.7 1.1 1 1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 3.84610183767818e-11 1.76457759978913e-09 1.6176656432163 0.696969696969697 1.1 1 1 ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY 3.15966839635048e-06 2.79598844334772e-05 1.6176656432163 0.696969696969697 1.1 1 1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS 3.15966839635048e-06 2.79598844334772e-05 1.6176656432163 0.696969696969697 1.1 1 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.15966839635048e-06 2.79598844334772e-05 1.6176656432163 0.696969696969697 1.1 1 1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 0.000109392290433002 0.000548417243102329 1.6146076741365 0.695652173913043 1.1 1 1 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY 0.000109392290433002 0.000548417243102329 1.6146076741365 0.695652173913043 1.1 1 1 BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY 0.000109392290433002 0.000548417243102329 1.6146076741365 0.695652173913043 1.1 1 1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY 0.000109392290433002 0.000548417243102329 1.6146076741365 0.695652173913043 1.1 1 1 GLIOMA%KEGG%HSA05214 GLIOMA 5.12218022804215e-10 1.73169093094194e-08 1.61289728465119 0.694915254237288 1.1 1 1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 8.96659145516269e-11 3.52908980108418e-09 1.60684513724161 0.692307692307692 1.1 1 1 ALDOSTERONE-REGULATED SODIUM REABSORPTION%KEGG%HSA04960 ALDOSTERONE-REGULATED SODIUM REABSORPTION 5.37405338757734e-07 6.40999812650801e-06 1.60684513724161 0.692307692307692 1.1 1 1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 SPECIFIC SIGNALS 4.43462283155721e-05 0.000258689591970936 1.60684513724161 0.692307692307692 1.1 1 1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING EPHRIN B REVERSE SIGNALING 4.43462283155721e-05 0.000258689591970936 1.60684513724161 0.692307692307692 1.1 1 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 4.43462283155721e-05 0.000258689591970936 1.60684513724161 0.692307692307692 1.1 1 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 4.43462283155721e-05 0.000258689591970936 1.60684513724161 0.692307692307692 1.1 1 1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY 0.00413854314333792 0.0121259314099801 1.60684513724161 0.692307692307692 1.1 1 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00413854314333792 0.0121259314099801 1.60684513724161 0.692307692307692 1.1 1 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00413854314333792 0.0121259314099801 1.60684513724161 0.692307692307692 1.1 1 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00413854314333792 0.0121259314099801 1.60684513724161 0.692307692307692 1.1 1 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00413854314333792 0.0121259314099801 1.60684513724161 0.692307692307692 1.1 1 1 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY INSULIN PATHWAY 2.22289053464244e-07 3.00603196915493e-06 1.60259422418013 0.69047619047619 1.1 1 1 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM%KEGG%HSA04070 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 1.57227622972417e-11 8.46141309751557e-10 1.60181588798577 0.690140845070423 1.1 1 1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY 1.80643498313863e-05 0.00011820270596865 1.60068864246291 0.689655172413793 1.1 1 1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY 1.80643498313863e-05 0.00011820270596865 1.60068864246291 0.689655172413793 1.1 1 1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES 9.20975006696376e-08 1.39575350152778e-06 1.59891009952684 0.688888888888889 1.1 1 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.07676542175085e-10 7.40058164480676e-09 1.59568649045521 0.6875 1.1 1 1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-CADHERIN SIGNALING EVENTS 7.38757245281066e-06 5.4568707445551e-05 1.59568649045521 0.6875 1.1 1 1 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00161626959293673 0.00547124893013371 1.59568649045521 0.6875 1.1 1 1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-BETA RECEPTOR SIGNALING 3.82124883798011e-08 6.45938024727791e-07 1.59568649045521 0.6875 1.1 1 1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L SIGNALING 3.03114197630795e-06 2.76578594862424e-05 1.59154185022026 0.685714285714286 1.1 1 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 3.03114197630795e-06 2.76578594862424e-05 1.59154185022026 0.685714285714286 1.1 1 1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM 0.000640083317798156 0.00257301784913679 1.58805162686452 0.684210526315789 1.1 1 1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY 0.000640083317798156 0.00257301784913679 1.58805162686452 0.684210526315789 1.1 1 1 NOTCH SIGNALING PATHWAY%KEGG%HSA04330 NOTCH SIGNALING PATHWAY 2.12547524076069e-07 2.90408197403416e-06 1.58249899879856 0.681818181818182 1.1 1 1 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY 0.000256053779186404 0.00114249376601446 1.58249899879856 0.681818181818182 1.1 1 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000256053779186404 0.00114249376601446 1.58249899879856 0.681818181818182 1.1 1 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 8.79904006938796e-08 1.34901561994047e-06 1.58025431936764 0.680851063829787 1.1 1 1 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) 3.64824960992145e-08 6.21110287111254e-07 1.57827900146843 0.68 1.1 1 1 CD40%IOB%CD40 CD40 0.000103211834976652 0.000522794650790615 1.57827900146843 0.68 1.1 1 1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY REELIN SIGNALING PATHWAY 0.000103211834976652 0.000522794650790615 1.57827900146843 0.68 1.1 1 1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR 0.000103211834976652 0.000522794650790615 1.57827900146843 0.68 1.1 1 1 ACUTE MYELOID LEUKEMIA%KEGG%HSA05221 ACUTE MYELOID LEUKEMIA 1.51468840536179e-08 2.8943719745935e-07 1.57652730446347 0.679245283018868 1.1 1 1 ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY 4.18513751796433e-05 0.00024816544332641 1.57496328928047 0.678571428571429 1.1 1 1 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY 1.70514272147847e-05 0.000112976415993435 1.57228932783857 0.67741935483871 1.1 1 1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO SIGNALING PATHWAY 1.70514272147847e-05 0.000112976415993435 1.57228932783857 0.67741935483871 1.1 1 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.70514272147847e-05 0.000112976415993435 1.57228932783857 0.67741935483871 1.1 1 1 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY REGULATION OF RAC1 ACTIVITY 6.97440027627423e-06 5.16614986756605e-05 1.57008724194524 0.676470588235294 1.1 1 1 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 NOTCH SIGNALING PATHWAY 6.97440027627423e-06 5.16614986756605e-05 1.57008724194524 0.676470588235294 1.1 1 1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY 2.86196148406456e-06 2.65739170192896e-05 1.56824225106163 0.675675675675676 1.1 1 1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB FORWARD SIGNALING 2.86196148406456e-06 2.65739170192896e-05 1.56824225106163 0.675675675675676 1.1 1 1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) 1.38353808600471e-11 7.60081235998837e-10 1.56742757976238 0.675324675324675 1.1 1 1 IFN-GAMMA%IOB%IFN-GAMMA IFN-GAMMA 1.17763563609824e-06 1.28323354231035e-05 1.56667400881057 0.675 1.1 1 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.00729705433164e-07 2.78591701698555e-06 1.56415118431973 0.673913043478261 1.1 1 1 NON-SMALL CELL LUNG CANCER%KEGG%HSA05223 NON-SMALL CELL LUNG CANCER 7.76971954178512e-08 1.20522061362867e-06 1.54733235438081 0.666666666666667 1.1 1 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.76971954178512e-08 1.20522061362867e-06 1.54733235438081 0.666666666666667 1.1 1 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.76971954178512e-08 1.20522061362867e-06 1.54733235438081 0.666666666666667 1.1 1 1 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING A6B1 AND A6B4 INTEGRIN SIGNALING 1.0984158793997e-06 1.21702633360379e-05 1.54733235438081 0.666666666666667 1.1 1 1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS CLASS I PI3K SIGNALING EVENTS 1.0984158793997e-06 1.21702633360379e-05 1.54733235438081 0.666666666666667 1.1 1 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000588382012941418 0.00239438791377549 1.54733235438081 0.666666666666667 1.1 1 1 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 SIGNALING EVENTS 9.66029330305818e-10 2.99696393413699e-08 1.54733235438081 0.666666666666667 1.1 1 1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA FORWARD SIGNALING 1.58433805657309e-05 0.000107125627055981 1.54733235438081 0.666666666666667 1.1 1 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.58433805657309e-05 0.000107125627055981 1.54733235438081 0.666666666666667 1.1 1 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 1.58433805657309e-05 0.000107125627055981 1.54733235438081 0.666666666666667 1.1 1 1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY 3.88150292917022e-05 0.000233287565631526 1.54733235438081 0.666666666666667 1.1 1 1 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-PHOSPHOINOSITIDE BIOSYNTHESIS 9.55065651265677e-05 0.000489030703376231 1.54733235438081 0.666666666666667 1.1 1 1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY 9.55065651265677e-05 0.000489030703376231 1.54733235438081 0.666666666666667 1.1 1 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 9.55065651265677e-05 0.000489030703376231 1.54733235438081 0.666666666666667 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 9.55065651265677e-05 0.000489030703376231 1.54733235438081 0.666666666666667 1.1 1 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 9.55065651265677e-05 0.000489030703376231 1.54733235438081 0.666666666666667 1.1 1 1 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY 0.000236257225322636 0.00106862830733412 1.54733235438081 0.666666666666667 1.1 1 1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY 0.00147816894763903 0.0050953353136263 1.54733235438081 0.666666666666667 1.1 1 1 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY 0.00147816894763903 0.0050953353136263 1.54733235438081 0.666666666666667 1.1 1 1 SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES 0.00375745112808573 0.011133616792377 1.54733235438081 0.666666666666667 1.1 1 1 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY 0.00375745112808573 0.011133616792377 1.54733235438081 0.666666666666667 1.1 1 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00375745112808573 0.011133616792377 1.54733235438081 0.666666666666667 1.1 1 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00375745112808573 0.011133616792377 1.54733235438081 0.666666666666667 1.1 1 1 EICOSAPENTAENOATE BIOSYNTHESIS%HUMANCYC%PWY-7049 EICOSAPENTAENOATE BIOSYNTHESIS 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00971183014410543 0.0249368024245434 1.54733235438081 0.666666666666667 1.1 1 1 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0257498902853812 0.0560713961045005 1.54733235438081 0.666666666666667 1.1 1 1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS INTEGRINS IN ANGIOGENESIS 5.1754708938841e-09 1.10957046724979e-07 1.53485386765193 0.661290322580645 1.1 1 1 INOSITOL PHOSPHATE METABOLISM%KEGG%HSA00562 INOSITOL PHOSPHATE METABOLISM 2.99041563081645e-08 5.22233511156489e-07 1.53351688693098 0.660714285714286 1.1 1 1 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY 2.99041563081645e-08 5.22233511156489e-07 1.53351688693098 0.660714285714286 1.1 1 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.99041563081645e-08 5.22233511156489e-07 1.53351688693098 0.660714285714286 1.1 1 1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 SIGNALING PATHWAY 7.20033311093077e-08 1.14381195262195e-06 1.53273487933948 0.660377358490566 1.1 1 1 PATHOGENIC ESCHERICHIA COLI INFECTION%KEGG%HSA05130 PATHOGENIC ESCHERICHIA COLI INFECTION 4.19162108365526e-07 5.11727073962913e-06 1.5308713718874 0.659574468085106 1.1 1 1 IL2%NETPATH%IL2 IL2 6.06630575554633e-11 2.62243414383208e-09 1.52774586888232 0.658227848101266 1.1 1 1 IL1%NETPATH%IL1 IL1 1.99206935764784e-09 5.15008519227191e-08 1.52423784162886 0.656716417910448 1.1 1 1 SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP 3.55006044876446e-05 0.000216201140955933 1.52315528634361 0.65625 1.1 1 1 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC 3.55006044876446e-05 0.000216201140955933 1.52315528634361 0.65625 1.1 1 1 COLORECTAL CANCER%KEGG%HSA05210 COLORECTAL CANCER 1.14631457795993e-08 2.25584443438831e-07 1.52196625021064 0.655737704918033 1.1 1 1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION 1.14631457795993e-08 2.25584443438831e-07 1.52196625021064 0.655737704918033 1.1 1 1 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA REGULATION OF P38-ALPHA AND P38-BETA 8.7046723341332e-05 0.000454539028616025 1.52065421033976 0.655172413793103 1.1 1 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.7046723341332e-05 0.000454539028616025 1.52065421033976 0.655172413793103 1.1 1 1 PROSTATE CANCER%KEGG%HSA05215 PROSTATE CANCER 2.34163606062555e-11 1.16507439469237e-09 1.51970141948116 0.654761904761905 1.1 1 1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF SIGNALING PATHWAY 1.59373836382492e-07 2.25950971258404e-06 1.51757596295041 0.653846153846154 1.1 1 1 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY 0.000214402425336471 0.000984981177024869 1.51757596295041 0.653846153846154 1.1 1 1 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY 0.000214402425336471 0.000984981177024869 1.51757596295041 0.653846153846154 1.1 1 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000214402425336471 0.000984981177024869 1.51757596295041 0.653846153846154 1.1 1 1 FOCAL ADHESION%KEGG%HSA04510 FOCAL ADHESION 5.81989337667588e-24 2.19243697632776e-21 1.51526329004131 0.652849740932642 1.1 1 1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION 7.64365008590289e-10 2.48843275018838e-08 1.51509626366455 0.652777777777778 1.1 1 1 PANCREATIC CANCER%KEGG%HSA05212 PANCREATIC CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 4.8728954577345e-08 1.51369469450297 0.652173913043478 1.1 1 1 FSH%NETPATH%FSH FSH 9.27293568618496e-07 1.04498852155854e-05 1.51369469450297 0.652173913043478 1.1 1 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 9.27293568618496e-07 1.04498852155854e-05 1.51369469450297 0.652173913043478 1.1 1 1 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY 0.000531044070599033 0.0021744770406361 1.51369469450297 0.652173913043478 1.1 1 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000531044070599033 0.0021744770406361 1.51369469450297 0.652173913043478 1.1 1 1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS 4.38125379410306e-09 9.70871113869728e-08 1.51216570996307 0.651515151515151 1.1 1 1 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY 5.43177444848147e-06 4.34852973233039e-05 1.50864904552129 0.65 1.1 1 1 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 SIGNALING EVENTS 5.43177444848147e-06 4.34852973233039e-05 1.50864904552129 0.65 1.1 1 1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES P38 SIGNALING MEDIATED BY MAPKAP KINASES 0.00132463791760038 0.00471759955557876 1.50864904552129 0.65 1.1 1 1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY CANONICAL WNT SIGNALING PATHWAY 0.00132463791760038 0.00471759955557876 1.50864904552129 0.65 1.1 1 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00132463791760038 0.00471759955557876 1.50864904552129 0.65 1.1 1 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00132463791760038 0.00471759955557876 1.50864904552129 0.65 1.1 1 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00132463791760038 0.00471759955557876 1.50864904552129 0.65 1.1 1 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00132463791760038 0.00471759955557876 1.50864904552129 0.65 1.1 1 1 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE 6.04536700088095e-08 9.78014281062764e-07 1.50661308189711 0.649122807017544 1.1 1 1 NOTCH%IOB%NOTCH NOTCH 6.9902214118114e-10 2.33331821049958e-08 1.50551256101917 0.648648648648649 1.1 1 1 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY 1.31881428007071e-05 9.10396140457189e-05 1.50551256101917 0.648648648648649 1.1 1 1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE 1.31881428007071e-05 9.10396140457189e-05 1.50551256101917 0.648648648648649 1.1 1 1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY P53 PATHWAY 1.45260399416263e-07 2.08180257206894e-06 1.50435090009246 0.648148148148148 1.1 1 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.21031777630685e-05 0.000198723191927727 1.50182257925197 0.647058823529412 1.1 1 1 SELENOCOMPOUND METABOLISM%KEGG%HSA00450 SELENOCOMPOUND METABOLISM 0.00333470438246099 0.0100844213951257 1.50182257925197 0.647058823529412 1.1 1 1 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY 0.00333470438246099 0.0100844213951257 1.50182257925197 0.647058823529412 1.1 1 1 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY 0.00333470438246099 0.0100844213951257 1.50182257925197 0.647058823529412 1.1 1 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00333470438246099 0.0100844213951257 1.50182257925197 0.647058823529412 1.1 1 1 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 INTEGRIN SIGNALLING PATHWAY 8.92778870034712e-19 1.3848575766362e-16 1.4974184074653 0.645161290322581 1.1 1 1 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 SIGNALING EVENTS 4.90207445769533e-06 4.06502212105113e-05 1.4920704845815 0.642857142857143 1.1 1 1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-MEDIATED THROMBIN SIGNALING EVENTS 4.90207445769533e-06 4.06502212105113e-05 1.4920704845815 0.642857142857143 1.1 1 1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY 0.000192085907031031 0.000898103788724872 1.4920704845815 0.642857142857143 1.1 1 1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 AXON GUIDANCE MEDIATED BY NETRIN 0.000192085907031031 0.000898103788724872 1.4920704845815 0.642857142857143 1.1 1 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000192085907031031 0.000898103788724872 1.4920704845815 0.642857142857143 1.1 1 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000192085907031031 0.000898103788724872 1.4920704845815 0.642857142857143 1.1 1 1 GLYCOSPHINGOLIPID BIOSYNTHESIS - GLOBO SERIES%KEGG%HSA00603 GLYCOSPHINGOLIPID BIOSYNTHESIS - GLOBO SERIES 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-MEDIATED SIGNALING EVENTS 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00850010738749963 0.0223700430946472 1.4920704845815 0.642857142857143 1.1 1 1 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B SIGNALING EVENTS MEDIATED BY PTP1B 3.15721056345026e-07 4.00267512298958e-06 1.4889424542155 0.641509433962264 1.1 1 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.15721056345026e-07 4.00267512298958e-06 1.4889424542155 0.641509433962264 1.1 1 1 NOTCH%NETPATH%NOTCH NOTCH 3.27468485423745e-09 7.50899474836882e-08 1.48286017294828 0.638888888888889 1.1 1 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.87608776947943e-05 0.000179721408723158 1.48286017294828 0.638888888888889 1.1 1 1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 1.18453919602965e-07 1.74906569439207e-06 1.48063699427819 0.637931034482759 1.1 1 1 GLYCOSPHINGOLIPID BIOSYNTHESIS - LACTO AND NEOLACTO SERIES%KEGG%HSA00601 GLYCOSPHINGOLIPID BIOSYNTHESIS - LACTO AND NEOLACTO SERIES 0.00116995642201269 0.00426589499229542 1.47699906554532 0.636363636363636 1.1 1 1 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY 0.00116995642201269 0.00426589499229542 1.47699906554532 0.636363636363636 1.1 1 1 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES 0.00116995642201269 0.00426589499229542 1.47699906554532 0.636363636363636 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00116995642201269 0.00426589499229542 1.47699906554532 0.636363636363636 1.1 1 1 BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0220551758056799 0.0487506274933594 1.47699906554532 0.636363636363636 1.1 1 1 ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY 6.99007463509933e-05 0.000374704067815059 1.47699906554532 0.636363636363636 1.1 1 1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 SIGNALING EVENTS MEDIATED BY PI3K 6.99007463509933e-05 0.000374704067815059 1.47699906554532 0.636363636363636 1.1 1 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.99007463509933e-05 0.000374704067815059 1.47699906554532 0.636363636363636 1.1 1 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 6.99007463509933e-05 0.000374704067815059 1.47699906554532 0.636363636363636 1.1 1 1 TIGHT JUNCTION%KEGG%HSA04530 TIGHT JUNCTION 6.05200160197051e-14 4.98722757012382e-12 1.4752109310834 0.635593220338983 1.1 1 1 VASOPRESSIN-REGULATED WATER REABSORPTION%KEGG%HSA04962 VASOPRESSIN-REGULATED WATER REABSORPTION 1.05882835149926e-05 7.44568096774282e-05 1.47185272733785 0.634146341463415 1.1 1 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00017035601306342 0.000810882322108734 1.46996573666177 0.633333333333333 1.1 1 1 IL5%NETPATH%IL5 IL5 2.53428859418893e-07 3.35825076526443e-06 1.4658938094134 0.631578947368421 1.1 1 1 APOPTOSIS%KEGG%HSA04210 APOPTOSIS 2.6378926380236e-09 6.40617969688055e-08 1.4658938094134 0.631578947368421 1.1 1 1 TSH%NETPATH%TSH TSH 2.6378926380236e-09 6.40617969688055e-08 1.4658938094134 0.631578947368421 1.1 1 1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY 2.55665530201758e-05 0.000161676259746292 1.4658938094134 0.631578947368421 1.1 1 1 GLYCOSAMINOGLYCAN DEGRADATION%KEGG%HSA00531 GLYCOSAMINOGLYCAN DEGRADATION 0.00291488717022339 0.00896914523673172 1.4658938094134 0.631578947368421 1.1 1 1 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 PATHWAY 0.00291488717022339 0.00896914523673172 1.4658938094134 0.631578947368421 1.1 1 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00291488717022339 0.00896914523673172 1.4658938094134 0.631578947368421 1.1 1 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00291488717022339 0.00896914523673172 1.4658938094134 0.631578947368421 1.1 1 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00291488717022339 0.00896914523673172 1.4658938094134 0.631578947368421 1.1 1 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.266780759294e-09 1.3012205403353e-07 1.46254701989419 0.63013698630137 1.1 1 1 THYROID CANCER%KEGG%HSA05216 THYROID CANCER 0.000416525387693305 0.00173245654155717 1.4613694458041 0.62962962962963 1.1 1 1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 INTERNALIZATION OF ERBB1 6.18384890241627e-05 0.000337615104672292 1.45891336270191 0.628571428571429 1.1 1 1 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY CERAMIDE SIGNALING PATHWAY 9.39071321050222e-06 6.65680396131569e-05 1.45737117098658 0.627906976744186 1.1 1 1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 TOLL RECEPTOR SIGNALING PATHWAY 9.39071321050222e-06 6.65680396131569e-05 1.45737117098658 0.627906976744186 1.1 1 1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS SYNDECAN-4-MEDIATED SIGNALING EVENTS 0.000149859565550186 0.000719817257478761 1.45062408223201 0.625 1.1 1 1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II SIGNALING EVENTS MEDIATED BY HDAC CLASS II 0.000149859565550186 0.000719817257478761 1.45062408223201 0.625 1.1 1 1 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 P38 MAPK PATHWAY 0.000149859565550186 0.000719817257478761 1.45062408223201 0.625 1.1 1 1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS 0.00102235547939302 0.00378644859432501 1.45062408223201 0.625 1.1 1 1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY 0.00102235547939302 0.00378644859432501 1.45062408223201 0.625 1.1 1 1 IL9%NETPATH%IL9 IL9 0.00102235547939302 0.00378644859432501 1.45062408223201 0.625 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00102235547939302 0.00378644859432501 1.45062408223201 0.625 1.1 1 1 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 AXON GUIDANCE MEDIATED BY SLIT ROBO 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 ENKEPHALIN RELEASE 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00732608702000074 0.0199781711186576 1.45062408223201 0.625 1.1 1 1 BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EPHRINA-EPHA PATHWAY 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR ANDROGENRECEPTOR 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0588169149851032 0.11150266341892 1.45062408223201 0.625 1.1 1 1 IL3%NETPATH%IL3 IL3 2.09436233250103e-09 5.36197424350021e-08 1.45062408223201 0.625 1.1 1 1 MELANOMA%KEGG%HSA05218 MELANOMA 3.13705032807519e-08 5.44236954943044e-07 1.44641937474728 0.623188405797101 1.1 1 1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 8.28245503950283e-06 5.9511809098553e-05 1.44417686408876 0.622222222222222 1.1 1 1 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY 8.28245503950283e-06 5.9511809098553e-05 1.44417686408876 0.622222222222222 1.1 1 1 SMALL CELL LUNG CANCER%KEGG%HSA05222 SMALL CELL LUNG CANCER 1.85733069832091e-09 4.89778105147225e-08 1.44354786719673 0.621951219512195 1.1 1 1 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY 5.43446564493662e-05 0.000301064829951636 1.4427828709767 0.621621621621622 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 5.43446564493662e-05 0.000301064829951636 1.4427828709767 0.621621621621622 1.1 1 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 5.43446564493662e-05 0.000301064829951636 1.4427828709767 0.621621621621622 1.1 1 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.43446564493662e-05 0.000301064829951636 1.4427828709767 0.621621621621622 1.1 1 1 ANGIOGENESIS%PANTHER PATHWAY%P00005 ANGIOGENESIS 4.4205517613605e-15 3.88566499823588e-13 1.44233480176211 0.621428571428571 1.1 1 1 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF SIGNALING PATHWAY 1.10959493241223e-10 4.18000262395866e-09 1.44146224592318 0.621052631578947 1.1 1 1 PROPANOATE METABOLISM%KEGG%HSA00640 PROPANOATE METABOLISM 0.000363968207614174 0.00153320153910316 1.44061977821662 0.620689655172414 1.1 1 1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY 0.000363968207614174 0.00153320153910316 1.44061977821662 0.620689655172414 1.1 1 1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING NONGENOTROPIC ANDROGEN SIGNALING 0.000363968207614174 0.00153320153910316 1.44061977821662 0.620689655172414 1.1 1 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.04992981234344e-06 2.77333272936195e-05 1.43901908957416 0.62 1.1 1 1 EGFR1%IOB%EGFR1 EGFR1 4.22299440176159e-44 1.11360362374453e-40 1.43880904445818 0.619909502262443 1.1 1 1 BCR%NETPATH%BCR BCR 2.38073689896381e-16 2.41461661637214e-14 1.43752167116669 0.619354838709677 1.1 1 1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING PRESENILIN ACTION IN NOTCH AND WNT SIGNALING 1.98283732331008e-05 0.000128786749299721 1.43680861478218 0.619047619047619 1.1 1 1 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY 0.00252105376267121 0.0078767994930853 1.43680861478218 0.619047619047619 1.1 1 1 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY 0.00252105376267121 0.0078767994930853 1.43680861478218 0.619047619047619 1.1 1 1 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY 0.00252105376267121 0.0078767994930853 1.43680861478218 0.619047619047619 1.1 1 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00252105376267121 0.0078767994930853 1.43680861478218 0.619047619047619 1.1 1 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00252105376267121 0.0078767994930853 1.43680861478218 0.619047619047619 1.1 1 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00252105376267121 0.0078767994930853 1.43680861478218 0.619047619047619 1.1 1 1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ERBB1 DOWNSTREAM SIGNALING 9.81501050019642e-11 3.80620333662029e-09 1.43566919478632 0.618556701030928 1.1 1 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000130958357146872 0.000640699791829872 1.43355791655869 0.617647058823529 1.1 1 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000130958357146872 0.000640699791829872 1.43355791655869 0.617647058823529 1.1 1 1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK 1.54917476956278e-07 2.20820209045246e-06 1.42830678865921 0.615384615384615 1.1 1 1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS INTEGRIN FAMILY CELL SURFACE INTERACTIONS 0.00088619026512194 0.003357591564837 1.42830678865921 0.615384615384615 1.1 1 1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- AND CXCR1-MEDIATED SIGNALING EVENTS 0.00088619026512194 0.003357591564837 1.42830678865921 0.615384615384615 1.1 1 1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR SA_REG_CASCADE_OF_CYCLIN_EXPR 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY RAS SIGNALING IN THE CD4+ TCR PATHWAY 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0186290893453335 0.042495595677893 1.42830678865921 0.615384615384615 1.1 1 1 EGFR1%NETPATH%EGFR1 EGFR1 8.64897223201621e-44 1.14036698879134e-40 1.42751679596637 0.615044247787611 1.1 1 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.73303022439549e-05 0.000114250017543272 1.4242490989187 0.613636363636364 1.1 1 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.73303022439549e-05 0.000114250017543272 1.4242490989187 0.613636363636364 1.1 1 1 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY 0.000315976443510848 0.00135926571213394 1.42254748709204 0.612903225806452 1.1 1 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 8.00881232688072e-09 1.6121555806095e-07 1.42161160058737 0.6125 1.1 1 1 INSULIN SIGNALING PATHWAY%KEGG%HSA04910 INSULIN SIGNALING PATHWAY 2.4418011448803e-13 1.95122109668162e-11 1.42138669762889 0.612403100775194 1.1 1 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.35446238921603e-06 4.77399353856486e-05 1.42101950912524 0.612244897959184 1.1 1 1 BACTERIAL INVASION OF EPITHELIAL CELLS%KEGG%HSA05100 BACTERIAL INVASION OF EPITHELIAL CELLS 1.35811065806885e-07 1.96776802490525e-06 1.42031253424507 0.611940298507463 1.1 1 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.51774352627528e-12 1.01322203524501e-10 1.41945364740719 0.611570247933884 1.1 1 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.51774352627528e-12 1.01322203524501e-10 1.41945364740719 0.611570247933884 1.1 1 1 GDNF%IOB%GDNF GDNF 0.000113817592541742 0.000564167277316866 1.41838799151574 0.611111111111111 1.1 1 1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY 0.000113817592541742 0.000564167277316866 1.41838799151574 0.611111111111111 1.1 1 1 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS 0.00625211720860976 0.0173911741340759 1.41838799151574 0.611111111111111 1.1 1 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00625211720860976 0.0173911741340759 1.41838799151574 0.611111111111111 1.1 1 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00625211720860976 0.0173911741340759 1.41838799151574 0.611111111111111 1.1 1 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00625211720860976 0.0173911741340759 1.41838799151574 0.611111111111111 1.1 1 1 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY 1.88117218508683e-08 3.46898674970208e-07 1.41671338940061 0.61038961038961 1.1 1 1 RANKL%NETPATH%RANKL RANKL 1.88117218508683e-08 3.46898674970208e-07 1.41671338940061 0.61038961038961 1.1 1 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.63861354948501e-07 9.86881006181464e-06 1.41620249384007 0.610169491525424 1.1 1 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.63861354948501e-07 9.86881006181464e-06 1.41620249384007 0.610169491525424 1.1 1 1 B CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04662 B CELL RECEPTOR SIGNALING PATHWAY 1.18726871177922e-07 1.74906569439207e-06 1.41278171486944 0.608695652173913 1.1 1 1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 TRANSCRIPTION FACTOR NETWORK 1.18726871177922e-07 1.74906569439207e-06 1.41278171486944 0.608695652173913 1.1 1 1 CCR1%IOB%CCR1 CCR1 0.00216382007976726 0.00695005304548877 1.41278171486944 0.608695652173913 1.1 1 1 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY 0.00216382007976726 0.00695005304548877 1.41278171486944 0.608695652173913 1.1 1 1 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC PATHWAY 0.00216382007976726 0.00695005304548877 1.41278171486944 0.608695652173913 1.1 1 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00216382007976726 0.00695005304548877 1.41278171486944 0.608695652173913 1.1 1 1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC)%KEGG%HSA05412 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC) 4.41506945136605e-08 7.36869502737486e-07 1.41141802595547 0.608108108108108 1.1 1 1 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 4.61401109343912e-18 6.40376171231524e-16 1.41006900036316 0.60752688172043 1.1 1 1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 1.50062233347264e-20 3.29761757780613e-18 1.40995237899186 0.607476635514019 1.1 1 1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY 6.13450364606264e-09 1.28386397735454e-07 1.40917767988253 0.607142857142857 1.1 1 1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY REGULATION OF CDC42 ACTIVITY 0.000763386403262273 0.00292169803396606 1.40917767988253 0.607142857142857 1.1 1 1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 GENERAL TRANSCRIPTION REGULATION 0.000763386403262273 0.00292169803396606 1.40917767988253 0.607142857142857 1.1 1 1 KITRECEPTOR%IOB%KITRECEPTOR KITRECEPTOR 2.2911344634817e-09 5.80934767327042e-08 1.40824630005445 0.606741573033708 1.1 1 1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA RECEPTOR MEDIATED EVENTS 7.52876759285996e-07 8.74597363100075e-06 1.40781878144484 0.60655737704918 1.1 1 1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY 0.000272873133548945 0.00121139133530062 1.40666577670983 0.606060606060606 1.1 1 1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS SYNDECAN-1-MEDIATED SIGNALING EVENTS 9.84710817074585e-05 0.000503233028028233 1.40481490068784 0.605263157894737 1.1 1 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 4.80368263636482e-06 4.00864275699178e-05 1.40135760396753 0.60377358490566 1.1 1 1 TOLL-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04620 TOLL-LIKE RECEPTOR SIGNALING PATHWAY 4.65962791015433e-09 1.02395323325641e-07 1.39787411560539 0.602272727272727 1.1 1 1 WNT%NETPATH%WNT WNT 2.97811175679085e-11 1.42786921866499e-09 1.39259911894273 0.6 1.1 1 1 GLUTATHIONE METABOLISM%KEGG%HSA00480 GLUTATHIONE METABOLISM 3.09020730506333e-05 0.000191738274434165 1.39259911894273 0.6 1.1 1 1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF SIGNALING PATHWAY 3.09020730506333e-05 0.000191738274434165 1.39259911894273 0.6 1.1 1 1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ERBB4 SIGNALING EVENTS 0.000234638159330934 0.00106312856727779 1.39259911894273 0.6 1.1 1 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000234638159330934 0.00106312856727779 1.39259911894273 0.6 1.1 1 1 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 PATHWAY 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00184671515290932 0.00599713058249905 1.39259911894273 0.6 1.1 1 1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR SIGNALING PATHWAY 1.53368533418839e-06 1.58010276623677e-05 1.39259911894273 0.6 1.1 1 1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY 8.4868241481571e-05 0.000446701702169467 1.39259911894273 0.6 1.1 1 1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR 8.4868241481571e-05 0.000446701702169467 1.39259911894273 0.6 1.1 1 1 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY 0.000654386499440304 0.00261853899700164 1.39259911894273 0.6 1.1 1 1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS NETRIN-MEDIATED SIGNALING EVENTS 0.000654386499440304 0.00261853899700164 1.39259911894273 0.6 1.1 1 1 NGF%IOB%NGF NGF 0.0053002610491579 0.0150288047168058 1.39259911894273 0.6 1.1 1 1 BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY 0.0053002610491579 0.0150288047168058 1.39259911894273 0.6 1.1 1 1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY 0.0053002610491579 0.0150288047168058 1.39259911894273 0.6 1.1 1 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0053002610491579 0.0150288047168058 1.39259911894273 0.6 1.1 1 1 GLUTATHIONE-MEDIATED DETOXIFICATION%HUMANCYC%PWY-4061 GLUTATHIONE-MEDIATED DETOXIFICATION 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 GLYCOSPHINGOLIPID BIOSYNTHESIS - GANGLIO SERIES%KEGG%HSA00604 GLYCOSPHINGOLIPID BIOSYNTHESIS - GANGLIO SERIES 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0156140917766205 0.0366646126580127 1.39259911894273 0.6 1.1 1 1 PURINE NUCLEOTIDES DEGRADATION%HUMANCYC%PWY-6353 PURINE NUCLEOTIDES DEGRADATION 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7226 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7227 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 FOLATE BIOSYNTHESIS%KEGG%HSA00790 FOLATE BIOSYNTHESIS 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0481480098464711 0.0941886513094542 1.39259911894273 0.6 1.1 1 1 WNT%IOB%WNT WNT 5.98673324822997e-11 2.62243414383208e-09 1.38445526444599 0.596491228070175 1.1 1 1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY NOTCH SIGNALING PATHWAY 3.58970411555736e-06 3.04374590119767e-05 1.38445526444599 0.596491228070175 1.1 1 1 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-MEDIATED SIGNALING EVENTS 9.7526859786427e-06 6.89486137417716e-05 1.38367220151361 0.596153846153846 1.1 1 1 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS ARF6 TRAFFICKING EVENTS 2.66008780787189e-05 0.000167198999113983 1.38272252944668 0.595744680851064 1.1 1 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 7.29073359937521e-05 0.00038918349193426 1.38154674498287 0.595238095238095 1.1 1 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000201044565477226 0.000938326582590167 1.38005318093424 0.594594594594595 1.1 1 1 TNFALPHA%NETPATH%TNFALPHA TNFALPHA 2.01177411844315e-22 5.30504835033459e-20 1.37640610593177 0.593023255813954 1.1 1 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.73801555789256e-13 6.00151383122431e-11 1.37602055800294 0.592857142857143 1.1 1 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 8.38845272931269e-06 6.01096463239064e-05 1.37540653722739 0.592592592592593 1.1 1 1 NEUROTROPHIN SIGNALING PATHWAY%KEGG%HSA04722 NEUROTROPHIN SIGNALING PATHWAY 3.88113389411337e-11 1.76457759978913e-09 1.37325746451297 0.591666666666667 1.1 1 1 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY 0.00447263881028907 0.0128338939529187 1.37149913229208 0.590909090909091 1.1 1 1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 ENDOGENOUS_CANNABINOID_SIGNALING 0.00447263881028907 0.0128338939529187 1.37149913229208 0.590909090909091 1.1 1 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00447263881028907 0.0128338939529187 1.37149913229208 0.590909090909091 1.1 1 1 GASTRIC ACID SECRETION%KEGG%HSA04971 GASTRIC ACID SECRETION 9.84045812808732e-07 1.10422502484112e-05 1.37149913229208 0.590909090909091 1.1 1 1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR ANDROGENRECEPTOR 1.25919214144654e-11 7.21845581955332e-10 1.37066842415623 0.590551181102362 1.1 1 1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF RECEPTOR SIGNALING PATHWAY 7.35110931535755e-10 2.42310940807473e-08 1.37049437102301 0.59047619047619 1.1 1 1 LEISHMANIASIS%KEGG%HSA05140 LEISHMANIASIS 2.65804968204787e-06 2.51228566722589e-05 1.36976962518957 0.590163934426229 1.1 1 1 LONG-TERM POTENTIATION%KEGG%HSA04720 LONG-TERM POTENTIATION 2.65804968204787e-06 2.51228566722589e-05 1.36976962518957 0.590163934426229 1.1 1 1 UNTITLED%PANTHER PATHWAY%P00019 UNTITLED 2.65804968204787e-06 2.51228566722589e-05 1.36976962518957 0.590163934426229 1.1 1 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.53693141485781e-12 1.01322203524501e-10 1.3692221553154 0.589928057553957 1.1 1 1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION 1.16919026258896e-07 1.74906569439207e-06 1.36879400579841 0.58974358974359 1.1 1 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 8.45541843485894e-07 9.7793589529487e-06 1.36529325386542 0.588235294117647 1.1 1 1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0.00047560852840905 0.0019627225186458 1.36529325386542 0.588235294117647 1.1 1 1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY 0.0130280622164861 0.0314894592711952 1.36529325386542 0.588235294117647 1.1 1 1 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY 0.0130280622164861 0.0314894592711952 1.36529325386542 0.588235294117647 1.1 1 1 GLYCOLYSIS%PANTHER PATHWAY%P00024 GLYCOLYSIS 0.0130280622164861 0.0314894592711952 1.36529325386542 0.588235294117647 1.1 1 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0130280622164861 0.0314894592711952 1.36529325386542 0.588235294117647 1.1 1 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.26619145867528e-14 4.47966028275056e-12 1.36358663729809 0.5875 1.1 1 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.28071672805278e-06 2.19498175615882e-05 1.36312612171643 0.587301587301587 1.1 1 1 REGULATION OF ACTIN CYTOSKELETON%KEGG%HSA04810 REGULATION OF ACTIN CYTOSKELETON 3.64992903161506e-17 4.37493766198587e-15 1.36257625236519 0.587064676616915 1.1 1 1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY 5.33795851224581e-05 0.000298224504169326 1.36232522505267 0.58695652173913 1.1 1 1 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS 5.33795851224581e-05 0.000298224504169326 1.36232522505267 0.58695652173913 1.1 1 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 5.33795851224581e-05 0.000298224504169326 1.36232522505267 0.58695652173913 1.1 1 1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING RETINOIC ACID RECEPTORS-MEDIATED SIGNALING 0.00132922884709709 0.00471759955557876 1.36058534609347 0.586206896551724 1.1 1 1 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY 0.00132922884709709 0.00471759955557876 1.36058534609347 0.586206896551724 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00132922884709709 0.00471759955557876 1.36058534609347 0.586206896551724 1.1 1 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00132922884709709 0.00471759955557876 1.36058534609347 0.586206896551724 1.1 1 1 UBIQUITIN MEDIATED PROTEOLYSIS%KEGG%HSA04120 UBIQUITIN MEDIATED PROTEOLYSIS 2.14534460214737e-11 1.0879372530505e-09 1.35996007709251 0.5859375 1.1 1 1 ENDOCRINE AND OTHER FACTOR-REGULATED CALCIUM REABSORPTION%KEGG%HSA04961 ENDOCRINE AND OTHER FACTOR-REGULATED CALCIUM REABSORPTION 0.000146358396086771 0.000710768122432439 1.3586332867734 0.585365853658537 1.1 1 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000146358396086771 0.000710768122432439 1.3586332867734 0.585365853658537 1.1 1 1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING THROMBOXANE A2 RECEPTOR SIGNALING 1.67262815973072e-05 0.00011194721972614 1.35756517884354 0.584905660377358 1.1 1 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.95369881266453e-06 1.89408226801337e-05 1.35689144922625 0.584615384615385 1.1 1 1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB TRANSCRIPTION FACTOR NETWORK 2.31441760830148e-07 3.08238345105606e-06 1.35642771325591 0.584415584415584 1.1 1 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.21359988538365e-07 7.28233906566964e-06 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.27390874046663e-06 4.25299613107355e-05 1.35391581008321 0.583333333333333 1.1 1 1 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY 0.000403786952835803 0.00168212668977569 1.35391581008321 0.583333333333333 1.1 1 1 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY 0.000403786952835803 0.00168212668977569 1.35391581008321 0.583333333333333 1.1 1 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000403786952835803 0.00168212668977569 1.35391581008321 0.583333333333333 1.1 1 1 GLYCOLYSIS%HUMANCYC%PWY66-400 GLYCOLYSIS 0.00376187052029121 0.011133616792377 1.35391581008321 0.583333333333333 1.1 1 1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-MEDIATED SIGNALING EVENTS 0.00376187052029121 0.011133616792377 1.35391581008321 0.583333333333333 1.1 1 1 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 PATHWAY 0.00376187052029121 0.011133616792377 1.35391581008321 0.583333333333333 1.1 1 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00376187052029121 0.011133616792377 1.35391581008321 0.583333333333333 1.1 1 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00376187052029121 0.011133616792377 1.35391581008321 0.583333333333333 1.1 1 1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0393358597318841 0.0793032584961608 1.35391581008321 0.583333333333333 1.1 1 1 CXCR4%IOB%CXCR4 CXCR4 2.37393634837646e-08 4.28771928127995e-07 1.35179035355247 0.582417582417582 1.1 1 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.67105211881906e-06 1.63812804361556e-05 1.35102899598922 0.582089552238806 1.1 1 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.67105211881906e-06 1.63812804361556e-05 1.35102899598922 0.582089552238806 1.1 1 1 G-CSF%IOB%G-CSF G-CSF 0.000124456617557765 0.000611158473928911 1.3494177509135 0.581395348837209 1.1 1 1 SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS 0.000124456617557765 0.000611158473928911 1.3494177509135 0.581395348837209 1.1 1 1 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 P53 PATHWAY FEEDBACK LOOPS 2 0.000124456617557765 0.000611158473928911 1.3494177509135 0.581395348837209 1.1 1 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 4.50303610709642e-06 3.78168987720168e-05 1.34767656671877 0.580645161290323 1.1 1 1 BASE EXCISION REPAIR%KEGG%HSA03410 BASE EXCISION REPAIR 0.00112295426918878 0.00414158099000115 1.34767656671877 0.580645161290323 1.1 1 1 OSTEOCLAST DIFFERENTIATION%KEGG%HSA04380 OSTEOCLAST DIFFERENTIATION 7.90245445444899e-10 2.51069546944361e-08 1.3470080763583 0.580357142857143 1.1 1 1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF SIGNALING PATHWAY 7.90245445444899e-10 2.51069546944361e-08 1.3470080763583 0.580357142857143 1.1 1 1 HYPERTROPHIC CARDIOMYOPATHY (HCM)%KEGG%HSA05410 HYPERTROPHIC CARDIOMYOPATHY (HCM) 1.69622734636906e-07 2.36664101183874e-06 1.34675223436849 0.580246913580247 1.1 1 1 TRAIL%IOB%TRAIL TRAIL 3.87582726334253e-05 0.000233287565631526 1.34617914831131 0.58 1.1 1 1 FC GAMMA R-MEDIATED PHAGOCYTOSIS%KEGG%HSA04666 FC GAMMA R-MEDIATED PHAGOCYTOSIS 5.42696521289415e-08 8.84677105328716e-07 1.34512414897877 0.579545454545455 1.1 1 1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 APOPTOSIS SIGNALING PATHWAY 1.74009478387321e-08 3.26933778666984e-07 1.34373599196228 0.578947368421053 1.1 1 1 GLYCOLYSIS / GLUCONEOGENESIS%KEGG%HSA00010 GLYCOLYSIS / GLUCONEOGENESIS 1.21630047023887e-05 8.46275551456438e-05 1.34373599196228 0.578947368421053 1.1 1 1 SHIGELLOSIS%KEGG%HSA05131 SHIGELLOSIS 1.21630047023887e-05 8.46275551456438e-05 1.34373599196228 0.578947368421053 1.1 1 1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS 1.21630047023887e-05 8.46275551456438e-05 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.0495001803345e-12 7.9072342158345e-11 1.34373599196228 0.578947368421053 1.1 1 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.54167303232331e-07 5.49375770010851e-06 1.34373599196228 0.578947368421053 1.1 1 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000342083105660654 0.00145261376751553 1.34373599196228 0.578947368421053 1.1 1 1 PROXIMAL TUBULE BICARBONATE RECLAMATION%KEGG%HSA04964 PROXIMAL TUBULE BICARBONATE RECLAMATION 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY%MSIGDB_C2%ST_WNT_CA2_CYCLIC_GMP_PATHWAY ST_WNT_CA2_CYCLIC_GMP_PATHWAY 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY ARF1 PATHWAY 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.010840808511391 0.0271741559358727 1.34373599196228 0.578947368421053 1.1 1 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 6.90083898413897e-18 8.66548209579737e-16 1.34264040615555 0.57847533632287 1.1 1 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.86798431666016e-10 6.74777348360665e-09 1.33976338001265 0.577235772357724 1.1 1 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.87609126154579e-07 4.80211749267963e-06 1.33903761436801 0.576923076923077 1.1 1 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.77914245179239e-09 1.04153707813029e-07 1.33903761436801 0.576923076923077 1.1 1 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 3.29445986733307e-05 0.000203454114055206 1.33903761436801 0.576923076923077 1.1 1 1 ID%IOB%ID ID 0.00315652181807393 0.00958957146804256 1.33903761436801 0.576923076923077 1.1 1 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00315652181807393 0.00958957146804256 1.33903761436801 0.576923076923077 1.1 1 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.2375996716696e-07 1.80306648297941e-06 1.33798738878811 0.576470588235294 1.1 1 1 CELL CYCLE%KEGG%HSA04110 CELL CYCLE 4.95354053475675e-10 1.69642680391605e-08 1.33752457751562 0.576271186440678 1.1 1 1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T CELL ACTIVATION 1.03494101489733e-05 7.29716432161566e-05 1.33752457751562 0.576271186440678 1.1 1 1 RENAL CELL CARCINOMA%KEGG%HSA05211 RENAL CELL CARCINOMA 3.26965645532597e-06 2.86447975837029e-05 1.33633248787434 0.575757575757576 1.1 1 1 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_RECEPTOR_II_SIGNALING 0.000946755564620326 0.00354126868638837 1.33633248787434 0.575757575757576 1.1 1 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000946755564620326 0.00354126868638837 1.33633248787434 0.575757575757576 1.1 1 1 BASAL TRANSCRIPTION FACTORS%KEGG%HSA03022 BASAL TRANSCRIPTION FACTORS 0.000289296459558747 0.00125061436697773 1.33457415565345 0.575 1.1 1 1 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-GAMMA PATHWAY 0.000289296459558747 0.00125061436697773 1.33457415565345 0.575 1.1 1 1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP RECEPTOR SIGNALING 0.000289296459558747 0.00125061436697773 1.33457415565345 0.575 1.1 1 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000289296459558747 0.00125061436697773 1.33457415565345 0.575 1.1 1 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000289296459558747 0.00125061436697773 1.33457415565345 0.575 1.1 1 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000289296459558747 0.00125061436697773 1.33457415565345 0.575 1.1 1 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.36522517537906e-10 5.07056167249943e-09 1.33411726617873 0.574803149606299 1.1 1 1 TYPE II DIABETES MELLITUS%KEGG%HSA04930 TYPE II DIABETES MELLITUS 8.95308396315055e-05 0.000464749653756457 1.33333958196644 0.574468085106383 1.1 1 1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FOXO FAMILY SIGNALING 8.95308396315055e-05 0.000464749653756457 1.33333958196644 0.574468085106383 1.1 1 1 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY 2.79642248541691e-05 0.000175158339525995 1.33242508293903 0.574074074074074 1.1 1 1 IL6%NETPATH%IL6 IL6 2.81467274417426e-07 3.67440199326115e-06 1.33032842663228 0.573170731707317 1.1 1 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.0857901889201e-12 7.9534131338397e-11 1.32837022876089 0.572327044025157 1.1 1 1 MAPK SIGNALING PATHWAY%KEGG%HSA04010 MAPK SIGNALING PATHWAY 4.68674673365833e-19 7.72434446041063e-17 1.32761116005874 0.572 1.1 1 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.74129033285873e-11 1.33866344587935e-09 1.32628487518355 0.571428571428571 1.1 1 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.4544109976333e-08 4.40291278963197e-07 1.32628487518355 0.571428571428571 1.1 1 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.5775607198574e-05 0.000400441435235751 1.32628487518355 0.571428571428571 1.1 1 1 CARBOHYDRATE DIGESTION AND ABSORPTION%KEGG%HSA04973 CARBOHYDRATE DIGESTION AND ABSORPTION 0.000244293142877461 0.00110119832097071 1.32628487518355 0.571428571428571 1.1 1 1 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS BETA3 INTEGRIN CELL SURFACE INTERACTIONS 0.000244293142877461 0.00110119832097071 1.32628487518355 0.571428571428571 1.1 1 1 IFN-ALPHA%IOB%IFN-ALPHA IFN-ALPHA 0.00079690235384653 0.00303236869710433 1.32628487518355 0.571428571428571 1.1 1 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00079690235384653 0.00303236869710433 1.32628487518355 0.571428571428571 1.1 1 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00079690235384653 0.00303236869710433 1.32628487518355 0.571428571428571 1.1 1 1 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY 0.00264394287705625 0.0082103526897679 1.32628487518355 0.571428571428571 1.1 1 1 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY 0.00900587076447347 0.0235133477286302 1.32628487518355 0.571428571428571 1.1 1 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00900587076447347 0.0235133477286302 1.32628487518355 0.571428571428571 1.1 1 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00900587076447347 0.0235133477286302 1.32628487518355 0.571428571428571 1.1 1 1 SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR SA_TRKA_RECEPTOR 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT SIGNALING PATHWAY 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0321343986224452 0.0662536428204753 1.32628487518355 0.571428571428571 1.1 1 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.08920067758721e-08 3.79946357710171e-07 1.32296916299559 0.57 1.1 1 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.03663842270313e-07 2.81184058673725e-06 1.32242939589523 0.569767441860465 1.1 1 1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B CELL ACTIVATION 6.40589582769579e-05 0.000349015440033756 1.31978347873658 0.568627450980392 1.1 1 1 TCR%NETPATH%TCR TCR 1.71966324111583e-18 2.51930664823468e-16 1.3195999715788 0.568548387096774 1.1 1 1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RHOA SIGNALING PATHWAY 0.000206033037923659 0.000956530142613891 1.31874916566547 0.568181818181818 1.1 1 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.000206033037923659 0.000956530142613891 1.31874916566547 0.568181818181818 1.1 1 1 PATHWAYS IN CANCER%KEGG%HSA05200 PATHWAYS IN CANCER 1.28122995703098e-22 3.75400377410077e-20 1.31772819856947 0.567741935483871 1.1 1 1 FRUCTOSE AND MANNOSE METABOLISM%KEGG%HSA00051 FRUCTOSE AND MANNOSE METABOLISM 0.000669886336243939 0.00264847456192349 1.31732349089177 0.567567567567568 1.1 1 1 PYRUVATE METABOLISM%KEGG%HSA00620 PYRUVATE METABOLISM 0.000669886336243939 0.00264847456192349 1.31732349089177 0.567567567567568 1.1 1 1 ID%NETPATH%ID ID 0.000669886336243939 0.00264847456192349 1.31732349089177 0.567567567567568 1.1 1 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.97629729155125e-12 2.39456966378559e-10 1.31572528222827 0.56687898089172 1.1 1 1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS ENDOTHELINS 1.69866042985586e-05 0.000112976415993435 1.31523250122369 0.566666666666667 1.1 1 1 CITRATE CYCLE (TCA CYCLE)%KEGG%HSA00020 CITRATE CYCLE (TCA CYCLE) 0.00221171499403287 0.00706088673034463 1.31523250122369 0.566666666666667 1.1 1 1 BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY 0.00221171499403287 0.00706088673034463 1.31523250122369 0.566666666666667 1.1 1 1 ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY ST_WNT_BETA_CATENIN_PATHWAY 0.00221171499403287 0.00706088673034463 1.31523250122369 0.566666666666667 1.1 1 1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING AURORA A SIGNALING 0.00221171499403287 0.00706088673034463 1.31523250122369 0.566666666666667 1.1 1 1 TNFALPHA%IOB%TNFALPHA TNFALPHA 3.32472915548818e-15 3.02321061483528e-13 1.31485138488025 0.566502463054187 1.1 1 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000173580998436573 0.000824744311490527 1.31186873523591 0.565217391304348 1.1 1 1 ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY ST_INTERLEUKIN_4_PATHWAY 0.00747410315996743 0.0202561254191512 1.31186873523591 0.565217391304348 1.1 1 1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT 0.00747410315996743 0.0202561254191512 1.31186873523591 0.565217391304348 1.1 1 1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 OXIDATIVE STRESS RESPONSE 0.00747410315996743 0.0202561254191512 1.31186873523591 0.565217391304348 1.1 1 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00747410315996743 0.0202561254191512 1.31186873523591 0.565217391304348 1.1 1 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00747410315996743 0.0202561254191512 1.31186873523591 0.565217391304348 1.1 1 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00747410315996743 0.0202561254191512 1.31186873523591 0.565217391304348 1.1 1 1 DILATED CARDIOMYOPATHY%KEGG%HSA05414 DILATED CARDIOMYOPATHY 3.89705401377869e-07 4.80211749267963e-06 1.31068152371081 0.564705882352941 1.1 1 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.89705401377869e-07 4.80211749267963e-06 1.31068152371081 0.564705882352941 1.1 1 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.89705401377869e-07 4.80211749267963e-06 1.31068152371081 0.564705882352941 1.1 1 1 TOXOPLASMOSIS%KEGG%HSA05145 TOXOPLASMOSIS 2.97755945197883e-09 6.94851705740546e-08 1.30928122293761 0.564102564102564 1.1 1 1 GM-CSF%IOB%GM-CSF GM-CSF 1.22157954444552e-06 1.32564002415754e-05 1.30928122293761 0.564102564102564 1.1 1 1 BLADDER CANCER%KEGG%HSA05219 BLADDER CANCER 0.0005625138805382 0.00229620604176352 1.30928122293761 0.564102564102564 1.1 1 1 WNT SIGNALING PATHWAY%KEGG%HSA04310 WNT SIGNALING PATHWAY 7.22002178132111e-11 2.92910729805289e-09 1.307604806519 0.563380281690141 1.1 1 1 HEPATITIS C%KEGG%HSA05160 HEPATITIS C 2.52687155379402e-09 6.28618895033475e-08 1.30678068584262 0.563025210084034 1.1 1 1 PHENYLALANINE METABOLISM%KEGG%HSA00360 PHENYLALANINE METABOLISM 0.0262700978922745 0.0566428848257792 1.30556167400881 0.5625 1.1 1 1 SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY 0.0262700978922745 0.0566428848257792 1.30556167400881 0.5625 1.1 1 1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 OPIOID PROENKEPHALIN PATHWAY 0.0262700978922745 0.0566428848257792 1.30556167400881 0.5625 1.1 1 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0262700978922745 0.0566428848257792 1.30556167400881 0.5625 1.1 1 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0262700978922745 0.0566428848257792 1.30556167400881 0.5625 1.1 1 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0262700978922745 0.0566428848257792 1.30556167400881 0.5625 1.1 1 1 TSLP%NETPATH%TSLP TSLP 1.68355555306515e-11 8.70497253614275e-10 1.30461355369363 0.562091503267974 1.1 1 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.79564366493368e-07 3.66771758429359e-06 1.30393175930967 0.561797752808989 1.1 1 1 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY COREGULATION OF ANDROGEN RECEPTOR ACTIVITY 3.84850496996204e-05 0.000233287565631526 1.30301671947858 0.56140350877193 1.1 1 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.74555817076076e-07 9.94053314495523e-06 1.30202356649117 0.560975609756098 1.1 1 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000471939540661828 0.001950634120259 1.30202356649117 0.560975609756098 1.1 1 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.06506899538109e-08 3.78165759779162e-07 1.3014945036848 0.560747663551402 1.1 1 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.74356238660205e-06 2.56552269981192e-05 1.29975917767988 0.56 1.1 1 1 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT INSULIN-MEDIATED GLUCOSE TRANSPORT 0.00619934098786816 0.0173174387553054 1.29975917767988 0.56 1.1 1 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00619934098786816 0.0173174387553054 1.29975917767988 0.56 1.1 1 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00619934098786816 0.0173174387553054 1.29975917767988 0.56 1.1 1 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00619934098786816 0.0173174387553054 1.29975917767988 0.56 1.1 1 1 ERBB SIGNALING PATHWAY%KEGG%HSA04012 ERBB SIGNALING PATHWAY 7.39339889384939e-07 8.62672251463754e-06 1.2986539402839 0.55952380952381 1.1 1 1 KITRECEPTOR%NETPATH%KITRECEPTOR KITRECEPTOR 5.4348764149887e-08 8.84677105328716e-07 1.29702859117215 0.558823529411765 1.1 1 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.24554407322096e-25 9.86916620180613e-23 1.29702859117215 0.558823529411765 1.1 1 1 VEGF SIGNALING PATHWAY%KEGG%HSA04370 VEGF SIGNALING PATHWAY 8.63637985339575e-06 6.17185194401208e-05 1.29702859117215 0.558823529411765 1.1 1 1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 0.00154354181048795 0.00527927335182453 1.29702859117215 0.558823529411765 1.1 1 1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT 0.00154354181048795 0.00527927335182453 1.29702859117215 0.558823529411765 1.1 1 1 NUCLEOTIDE EXCISION REPAIR%KEGG%HSA03420 NUCLEOTIDE EXCISION REPAIR 0.000395665595912868 0.00165614313717815 1.29544104087696 0.558139534883721 1.1 1 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000395665595912868 0.00165614313717815 1.29544104087696 0.558139534883721 1.1 1 1 LEPTIN%NETPATH%LEPTIN LEPTIN 1.69175962903015e-07 2.36664101183874e-06 1.29487286498184 0.557894736842105 1.1 1 1 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR SIGNALING IN NAIVE CD8+ T CELLS 0.000103290107342401 0.000522794650790615 1.29440302722241 0.557692307692308 1.1 1 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000103290107342401 0.000522794650790615 1.29440302722241 0.557692307692308 1.1 1 1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-MEDIATED SIGNALING EVENTS 1.64901023014712e-06 1.63475187101427e-05 1.28944362865068 0.555555555555556 1.1 1 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.64901023014712e-06 1.63475187101427e-05 1.28944362865068 0.555555555555556 1.1 1 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.64901023014712e-06 1.63475187101427e-05 1.28944362865068 0.555555555555556 1.1 1 1 BDNF%IOB%BDNF BDNF 0.000331522998863142 0.00141460541747913 1.28944362865068 0.555555555555556 1.1 1 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.000331522998863142 0.00141460541747913 1.28944362865068 0.555555555555556 1.1 1 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.000331522998863142 0.00141460541747913 1.28944362865068 0.555555555555556 1.1 1 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.2075709046429e-07 1.76909137530185e-06 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.13564856636739e-06 4.62277293414594e-05 1.28944362865068 0.555555555555556 1.1 1 1 P53 PATHWAY%PANTHER PATHWAY%P00059 P53 PATHWAY 8.67673008443098e-05 0.000454539028616025 1.28944362865068 0.555555555555556 1.1 1 1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING AURORA B SIGNALING 0.00128829660510994 0.00463953300645732 1.28944362865068 0.555555555555556 1.1 1 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00128829660510994 0.00463953300645732 1.28944362865068 0.555555555555556 1.1 1 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0051405001184846 0.0146387676160301 1.28944362865068 0.555555555555556 1.1 1 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0051405001184846 0.0146387676160301 1.28944362865068 0.555555555555556 1.1 1 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0051405001184846 0.0146387676160301 1.28944362865068 0.555555555555556 1.1 1 1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 HEDGEHOG SIGNALING PATHWAY 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0214979934763316 0.0482469862102863 1.28944362865068 0.555555555555556 1.1 1 1 GLYCOGENOLYSIS%HUMANCYC%PWY-5941-1 GLYCOGENOLYSIS 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 NORADRENALINE AND ADRENALINE DEGRADATION 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 FRUCTOSE GALACTOSE METABOLISM 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 SALVAGE PYRIMIDINE RIBONUCLEOTIDES 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.100150695859756 0.169946837182867 1.28944362865068 0.555555555555556 1.1 1 1 ECM-RECEPTOR INTERACTION%KEGG%HSA04512 ECM-RECEPTOR INTERACTION 1.17178254560423e-06 1.28215376463002e-05 1.2833756586335 0.552941176470588 1.1 1 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00107481973872917 0.00396960735438211 1.28265708323673 0.552631578947368 1.1 1 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 7.2614071945168e-08 1.14660663305035e-06 1.2820753793441 0.552380952380952 1.1 1 1 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS BETA1 INTEGRIN CELL SURFACE INTERACTIONS 1.62486513441239e-05 0.00010930534080218 1.28174545773336 0.552238805970149 1.1 1 1 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 TRANSCRIPTION FACTOR NETWORK 6.11405982581924e-05 0.000334497422420858 1.28055091397033 0.551724137931034 1.1 1 1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.00426205245239059 0.0124325578727367 1.28055091397033 0.551724137931034 1.1 1 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.44238684832806e-18 8.49428705952054e-16 1.27996242549883 0.551470588235294 1.1 1 1 MTOR SIGNALING PATHWAY%KEGG%HSA04150 MTOR SIGNALING PATHWAY 0.000232425774217898 0.00105673580450448 1.27891755821271 0.551020408163265 1.1 1 1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY REGULATION OF ANDROGEN RECEPTOR ACTIVITY 0.000232425774217898 0.00105673580450448 1.27891755821271 0.551020408163265 1.1 1 1 LYSINE DEGRADATION%KEGG%HSA00310 LYSINE DEGRADATION 0.00089644628395753 0.00337704121542287 1.27654919236417 0.55 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00089644628395753 0.00337704121542287 1.27654919236417 0.55 1.1 1 1 BIOSYNTHESIS OF UNSATURATED FATTY ACIDS%KEGG%HSA01040 BIOSYNTHESIS OF UNSATURATED FATTY ACIDS 0.0176125887430093 0.0406693489626229 1.27654919236417 0.55 1.1 1 1 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY 0.0176125887430093 0.0406693489626229 1.27654919236417 0.55 1.1 1 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0176125887430093 0.0406693489626229 1.27654919236417 0.55 1.1 1 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0176125887430093 0.0406693489626229 1.27654919236417 0.55 1.1 1 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0176125887430093 0.0406693489626229 1.27654919236417 0.55 1.1 1 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0176125887430093 0.0406693489626229 1.27654919236417 0.55 1.1 1 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.1473384460355e-05 8.04662628243512e-05 1.27491468635602 0.549295774647887 1.1 1 1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR SIGNALING IN NAIVE CD4+ T CELLS 4.30173874584943e-05 0.000253773715275279 1.27280564634551 0.548387096774194 1.1 1 1 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0.00353378158848641 0.0106376507406834 1.27280564634551 0.548387096774194 1.1 1 1 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY 0.00353378158848641 0.0106376507406834 1.27280564634551 0.548387096774194 1.1 1 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00353378158848641 0.0106376507406834 1.27280564634551 0.548387096774194 1.1 1 1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES 0.000747511495874482 0.00286926901691559 1.27102300538424 0.547619047619048 1.1 1 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 4.95757408564499e-07 5.96946249490677e-06 1.27044130149161 0.547368421052632 1.1 1 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 3.60665211890813e-05 0.000219141512386192 1.26929607195301 0.546875 1.1 1 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.99548976892553e-12 2.39456966378559e-10 1.26830520850886 0.546448087431694 1.1 1 1 LEUKOCYTE TRANSENDOTHELIAL MIGRATION%KEGG%HSA04670 LEUKOCYTE TRANSENDOTHELIAL MIGRATION 9.54510737795244e-08 1.4383113231806e-06 1.2679529015065 0.546296296296296 1.1 1 1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY FANCONI ANEMIA PATHWAY 0.000623224665499917 0.00251291046318545 1.26599919903885 0.545454545454545 1.1 1 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000623224665499917 0.00251291046318545 1.26599919903885 0.545454545454545 1.1 1 1 SNARE INTERACTIONS IN VESICULAR TRANSPORT%KEGG%HSA04130 SNARE INTERACTIONS IN VESICULAR TRANSPORT 0.0029302490096237 0.00897452571240149 1.26599919903885 0.545454545454545 1.1 1 1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-MEDIATED SIGNALING EVENTS 0.0029302490096237 0.00897452571240149 1.26599919903885 0.545454545454545 1.1 1 1 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA 0.0029302490096237 0.00897452571240149 1.26599919903885 0.545454545454545 1.1 1 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0029302490096237 0.00897452571240149 1.26599919903885 0.545454545454545 1.1 1 1 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY 0.0144457491094948 0.0345675502738092 1.26599919903885 0.545454545454545 1.1 1 1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL SIGNALING PATHWAY 0.0144457491094948 0.0345675502738092 1.26599919903885 0.545454545454545 1.1 1 1 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA REPLICATION 0.0144457491094948 0.0345675502738092 1.26599919903885 0.545454545454545 1.1 1 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0144457491094948 0.0345675502738092 1.26599919903885 0.545454545454545 1.1 1 1 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 ST_STAT3_PATHWAY%MSIGDB_C2%ST_STAT3_PATHWAY ST_STAT3_PATHWAY 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0794594106954205 0.143812262185191 1.26599919903885 0.545454545454545 1.1 1 1 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS)%KEGG%HSA05142 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS) 2.94926107149714e-07 3.83113371701377e-06 1.26391009144967 0.544554455445545 1.1 1 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.2927985819414e-06 1.38581701649572e-05 1.26365475607766 0.544444444444444 1.1 1 1 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY 0.000519549189847149 0.00213736538787353 1.26141224541914 0.543478260869565 1.1 1 1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN 0.00243017616524962 0.00768390233544753 1.25997063142438 0.542857142857143 1.1 1 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00243017616524962 0.00768390233544753 1.25997063142438 0.542857142857143 1.1 1 1 ENDOCYTOSIS%KEGG%HSA04144 ENDOCYTOSIS 4.37539998506022e-12 2.56398439124529e-10 1.25926516074609 0.542553191489362 1.1 1 1 ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY 0.0118612871886757 0.0289345183316723 1.25720753793441 0.541666666666667 1.1 1 1 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 DE NOVO PURINE BIOSYNTHESIS 0.0118612871886757 0.0289345183316723 1.25720753793441 0.541666666666667 1.1 1 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0118612871886757 0.0289345183316723 1.25720753793441 0.541666666666667 1.1 1 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0118612871886757 0.0289345183316723 1.25720753793441 0.541666666666667 1.1 1 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.36570464622209e-06 2.8722858097371e-05 1.25606979355619 0.541176470588235 1.1 1 1 TYROSINE METABOLISM%KEGG%HSA00350 TYROSINE METABOLISM 0.00201583809789349 0.00652241112165046 1.25459380084931 0.540540540540541 1.1 1 1 OOCYTE MEIOSIS%KEGG%HSA04114 OOCYTE MEIOSIS 5.39635792220242e-07 6.40999812650801e-06 1.25333920704846 0.54 1.1 1 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.39635792220242e-07 6.40999812650801e-06 1.25333920704846 0.54 1.1 1 1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY 0.000361012917060243 0.00152807554139303 1.25333920704846 0.54 1.1 1 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000361012917060243 0.00152807554139303 1.25333920704846 0.54 1.1 1 1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I SIGNALING EVENTS MEDIATED BY HDAC CLASS I 6.6514599785774e-05 0.000361647421928012 1.2526023821178 0.53968253968254 1.1 1 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.89386976678268e-09 8.70180896186943e-08 1.25233733717872 0.539568345323741 1.1 1 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.75084291120515e-09 6.59452068804362e-08 1.24976844007681 0.538461538461538 1.1 1 1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING 0.00167250990661865 0.00558279572627009 1.24976844007681 0.538461538461538 1.1 1 1 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ERBB2 ERBB3 SIGNALING EVENTS 0.00167250990661865 0.00558279572627009 1.24976844007681 0.538461538461538 1.1 1 1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 SIGNALING EVENTS 0.0097492966859614 0.0249600925833788 1.24976844007681 0.538461538461538 1.1 1 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0097492966859614 0.0249600925833788 1.24976844007681 0.538461538461538 1.1 1 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0097492966859614 0.0249600925833788 1.24976844007681 0.538461538461538 1.1 1 1 &GAMMA;-LINOLENATE BIOSYNTHESIS%HUMANCYC%PWY-6000 &GAMMA;-LINOLENATE BIOSYNTHESIS 0.0634937585161931 0.118915512221024 1.24976844007681 0.538461538461538 1.1 1 1 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04375 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.0634937585161931 0.118915512221024 1.24976844007681 0.538461538461538 1.1 1 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0634937585161931 0.118915512221024 1.24976844007681 0.538461538461538 1.1 1 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0634937585161931 0.118915512221024 1.24976844007681 0.538461538461538 1.1 1 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0634937585161931 0.118915512221024 1.24976844007681 0.538461538461538 1.1 1 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.19021452065307e-08 2.324885697009e-07 1.24841587682997 0.537878787878788 1.1 1 1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 HUNTINGTON DISEASE 3.18896487573111e-07 4.02358869727413e-06 1.24808411603358 0.537735849056604 1.1 1 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.66355374267043e-06 1.63812804361556e-05 1.24784867288775 0.537634408602151 1.1 1 1 IL4%NETPATH%IL4 IL4 8.74504494045613e-06 6.23261716431968e-05 1.24753671071953 0.5375 1.1 1 1 RAS PATHWAY%PANTHER PATHWAY%P04393 RAS PATHWAY 4.6468873898715e-05 0.000262957983843157 1.24710368860543 0.537313432835821 1.1 1 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.6468873898715e-05 0.000262957983843157 1.24710368860543 0.537313432835821 1.1 1 1 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 KINASE PATHWAY 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00138798040777361 0.00485424978156366 1.24541384620895 0.536585365853659 1.1 1 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.88370274221615e-05 0.000233287565631526 1.24459341548022 0.536231884057971 1.1 1 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.88370274221615e-05 0.000233287565631526 1.24459341548022 0.536231884057971 1.1 1 1 AXON GUIDANCE%KEGG%HSA04360 AXON GUIDANCE 3.63633717792102e-08 6.21110287111254e-07 1.24405521292217 0.536 1.1 1 1 EPO%IOB%EPO EPO 0.000209104932491586 0.000967385450842653 1.24339207048458 0.535714285714286 1.1 1 1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY 0.000209104932491586 0.000967385450842653 1.24339207048458 0.535714285714286 1.1 1 1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY 0.00802114308936341 0.0215175527229413 1.24339207048458 0.535714285714286 1.1 1 1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION REGULATION OF RAS FAMILY ACTIVATION 0.00802114308936341 0.0215175527229413 1.24339207048458 0.535714285714286 1.1 1 1 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE 0.00802114308936341 0.0215175527229413 1.24339207048458 0.535714285714286 1.1 1 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00802114308936341 0.0215175527229413 1.24339207048458 0.535714285714286 1.1 1 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00802114308936341 0.0215175527229413 1.24339207048458 0.535714285714286 1.1 1 1 MINERAL ABSORPTION%KEGG%HSA04978 MINERAL ABSORPTION 0.00115213428083034 0.00423734741778189 1.24146433084042 0.534883720930233 1.1 1 1 M-CSF%IOB%M-CSF M-CSF 0.000174317326741995 0.000826753220537122 1.24053369790875 0.53448275862069 1.1 1 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.29439073115145e-06 3.61798989074964e-05 1.23962421572554 0.534090909090909 1.1 1 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.26675863908562e-05 0.000144034759789609 1.23786588350465 0.533333333333333 1.1 1 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.26675863908562e-05 0.000144034759789609 1.23786588350465 0.533333333333333 1.1 1 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.26675863908562e-05 0.000144034759789609 1.23786588350465 0.533333333333333 1.1 1 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.26675863908562e-05 0.000144034759789609 1.23786588350465 0.533333333333333 1.1 1 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.26675863908562e-05 0.000144034759789609 1.23786588350465 0.533333333333333 1.1 1 1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY MTOR SIGNALING PATHWAY 0.000145324717343257 0.00070835726364911 1.23786588350465 0.533333333333333 1.1 1 1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN REGULATION OF RETINOBLASTOMA PROTEIN 0.000145324717343257 0.00070835726364911 1.23786588350465 0.533333333333333 1.1 1 1 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY 0.0066052952619423 0.0182771916114815 1.23786588350465 0.533333333333333 1.1 1 1 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 SIGNALING EVENTS MEDIATED BY STAT5 0.0066052952619423 0.0182771916114815 1.23786588350465 0.533333333333333 1.1 1 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0066052952619423 0.0182771916114815 1.23786588350465 0.533333333333333 1.1 1 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0066052952619423 0.0182771916114815 1.23786588350465 0.533333333333333 1.1 1 1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%HUMANCYC%PWY-7200 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-MEDIATED THROMBIN SIGNALING EVENTS 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0510147493033876 0.0986260219303761 1.23786588350465 0.533333333333333 1.1 1 1 CARDIAC MUSCLE CONTRACTION%KEGG%HSA04260 CARDIAC MUSCLE CONTRACTION 0.000121161426333602 0.00059831962779346 1.23537018615887 0.532258064516129 1.1 1 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.000121161426333602 0.00059831962779346 1.23537018615887 0.532258064516129 1.1 1 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000794442473975419 0.00303236869710433 1.23457368700597 0.531914893617021 1.1 1 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.58297082693242e-05 0.000107125627055981 1.23394858640495 0.531645569620253 1.1 1 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.58297082693242e-05 0.000107125627055981 1.23394858640495 0.531645569620253 1.1 1 1 FAS%IOB%FAS FAS 3.38832873681702e-07 4.25477279951737e-06 1.23368390416849 0.531531531531532 1.1 1 1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- AND CXCR2-MEDIATED SIGNALING EVENTS 0.00544394476204805 0.0153208989728076 1.23303046989721 0.53125 1.1 1 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00544394476204805 0.0153208989728076 1.23303046989721 0.53125 1.1 1 1 AMOEBIASIS%KEGG%HSA05146 AMOEBIASIS 1.76316702114341e-06 1.72202645731673e-05 1.23155024124187 0.530612244897959 1.1 1 1 ANTIGEN PROCESSING AND PRESENTATION%KEGG%HSA04612 ANTIGEN PROCESSING AND PRESENTATION 0.000659934800008892 0.00263275048051959 1.23155024124187 0.530612244897959 1.1 1 1 PNAT%PANTHER PATHWAY%P05912 PNAT 0.000659934800008892 0.00263275048051959 1.23155024124187 0.530612244897959 1.1 1 1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7219 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 ALPHA-LINOLENIC ACID METABOLISM%KEGG%HSA00592 ALPHA-LINOLENIC ACID METABOLISM 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0411673880275365 0.08199351558582 1.22876392847888 0.529411764705882 1.1 1 1 ADIPOCYTOKINE SIGNALING PATHWAY%KEGG%HSA04920 ADIPOCYTOKINE SIGNALING PATHWAY 5.85822307669256e-05 0.000322508021988273 1.22681350954479 0.528571428571429 1.1 1 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.85822307669256e-05 0.000322508021988273 1.22681350954479 0.528571428571429 1.1 1 1 CHOLINERGIC SYNAPSE%KEGG%HSA04725 CHOLINERGIC SYNAPSE 8.64503270488882e-07 9.86881006181464e-06 1.22618790347159 0.528301886792453 1.1 1 1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F TRANSCRIPTION FACTOR NETWORK 4.88593904079535e-05 0.000275303872875584 1.22497144721814 0.527777777777778 1.1 1 1 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-841 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.00370639449717041 0.0111065480557254 1.22497144721814 0.527777777777778 1.1 1 1 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY 0.00370639449717041 0.0111065480557254 1.22497144721814 0.527777777777778 1.1 1 1 BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY 0.00370639449717041 0.0111065480557254 1.22497144721814 0.527777777777778 1.1 1 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00370639449717041 0.0111065480557254 1.22497144721814 0.527777777777778 1.1 1 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.20522654196701e-08 1.26533230357702e-06 1.22446379224623 0.52755905511811 1.1 1 1 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 ALZHEIMER DISEASE-PRESENILIN PATHWAY 3.76558257677336e-06 3.18264142786902e-05 1.22157817451117 0.526315789473684 1.1 1 1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING 0.000314970061159675 0.00135715041058507 1.22157817451117 0.526315789473684 1.1 1 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00306141405252049 0.00932211184352947 1.22157817451117 0.526315789473684 1.1 1 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00306141405252049 0.00932211184352947 1.22157817451117 0.526315789473684 1.1 1 1 CDP-DIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%PWY-5667 CDP-DIACYLGLYCEROL BIOSYNTHESIS 0.0333393101040433 0.0681517525150094 1.22157817451117 0.526315789473684 1.1 1 1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY 0.0333393101040433 0.0681517525150094 1.22157817451117 0.526315789473684 1.1 1 1 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY 0.0333393101040433 0.0681517525150094 1.22157817451117 0.526315789473684 1.1 1 1 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY 0.0333393101040433 0.0681517525150094 1.22157817451117 0.526315789473684 1.1 1 1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 P53 PATHWAY BY GLUCOSE DEPRIVATION 0.0333393101040433 0.0681517525150094 1.22157817451117 0.526315789473684 1.1 1 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0333393101040433 0.0681517525150094 1.22157817451117 0.526315789473684 1.1 1 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.87218694410833e-09 8.70180896186943e-08 1.22001204864641 0.525641025641026 1.1 1 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.24394175888143e-09 7.50374948962309e-08 1.21925872228108 0.525316455696203 1.1 1 1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING REGULATION OF NUCLEAR SMAD2 3 SIGNALING 2.36601256328095e-05 0.000149980171379131 1.21852422907489 0.525 1.1 1 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00253026443692828 0.00789622168068625 1.21852422907489 0.525 1.1 1 1 T CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04660 T CELL RECEPTOR SIGNALING PATHWAY 1.83736853783955e-06 1.78787484659885e-05 1.21683418160044 0.524271844660194 1.1 1 1 BILE SECRETION%KEGG%HSA04976 BILE SECRETION 0.000181272935536212 0.000853601305373199 1.21576113558492 0.523809523809524 1.1 1 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00209249621086264 0.0067538708788798 1.21576113558492 0.523809523809524 1.1 1 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00209249621086264 0.0067538708788798 1.21576113558492 0.523809523809524 1.1 1 1 MUCIN CORE 1 AND CORE 2 O< I>-GLYCOSYLATION%HUMANCYC%PWY-7433 MUCIN CORE 1 AND CORE 2 O< I>-GLYCOSYLATION 0.0270799785193987 0.0580487997314422 1.21576113558492 0.523809523809524 1.1 1 1 DORSO-VENTRAL AXIS FORMATION%KEGG%HSA04320 DORSO-VENTRAL AXIS FORMATION 0.0270799785193987 0.0580487997314422 1.21576113558492 0.523809523809524 1.1 1 1 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY 0.0270799785193987 0.0580487997314422 1.21576113558492 0.523809523809524 1.1 1 1 BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY 0.0270799785193987 0.0580487997314422 1.21576113558492 0.523809523809524 1.1 1 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0270799785193987 0.0580487997314422 1.21576113558492 0.523809523809524 1.1 1 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0270799785193987 0.0580487997314422 1.21576113558492 0.523809523809524 1.1 1 1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE REGULATION OF TELOMERASE 0.000150843399004554 0.000723225533045473 1.21406077036033 0.523076923076923 1.1 1 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.07294674303657e-06 1.19888159380823e-05 1.21373317706018 0.522935779816514 1.1 1 1 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION 0.00173141624047795 0.00571001943445206 1.21324923241223 0.522727272727273 1.1 1 1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK NOTCH-MEDIATED HES HEY NETWORK 0.00143337851765576 0.00497814067633569 1.21095575560237 0.521739130434783 1.1 1 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00143337851765576 0.00497814067633569 1.21095575560237 0.521739130434783 1.1 1 1 ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY 0.0220511810544337 0.0487506274933594 1.21095575560237 0.521739130434783 1.1 1 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0220511810544337 0.0487506274933594 1.21095575560237 0.521739130434783 1.1 1 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 6.67056571974044e-06 4.99723914856691e-05 1.20988221326585 0.521276595744681 1.1 1 1 CHEMOKINE SIGNALING PATHWAY%KEGG%HSA04062 CHEMOKINE SIGNALING PATHWAY 2.80968307609752e-09 6.6748957402425e-08 1.20973256797045 0.521212121212121 1.1 1 1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING 0.00118721334120979 0.00430630203682286 1.20885340186001 0.520833333333333 1.1 1 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.00118721334120979 0.00430630203682286 1.20885340186001 0.520833333333333 1.1 1 1 FC EPSILON RI SIGNALING PATHWAY%KEGG%HSA04664 FC EPSILON RI SIGNALING PATHWAY 7.24571674003155e-05 0.000387565011023594 1.20819101643433 0.520547945205479 1.1 1 1 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM%KEGG%HSA00520 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 0.00098376683986993 0.00366819615828725 1.20691923641703 0.52 1.1 1 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00098376683986993 0.00366819615828725 1.20691923641703 0.52 1.1 1 1 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS 0.0179950622395505 0.0413353476704658 1.20691923641703 0.52 1.1 1 1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III SIGNALING EVENTS MEDIATED BY HDAC CLASS III 0.0179950622395505 0.0413353476704658 1.20691923641703 0.52 1.1 1 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0179950622395505 0.0413353476704658 1.20691923641703 0.52 1.1 1 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0179950622395505 0.0413353476704658 1.20691923641703 0.52 1.1 1 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0179950622395505 0.0413353476704658 1.20691923641703 0.52 1.1 1 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0179950622395505 0.0413353476704658 1.20691923641703 0.52 1.1 1 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.70592876646765e-06 2.53933599899473e-05 1.20513385293121 0.519230769230769 1.1 1 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.18785067426061e-05 0.00024816544332641 1.20456885815721 0.518987341772152 1.1 1 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.97542426039187e-10 1.39775916995378e-08 1.20394041477224 0.518716577540107 1.1 1 1 GAP JUNCTION%KEGG%HSA04540 GAP JUNCTION 3.48944047482117e-05 0.000213495464781982 1.20348072007397 0.518518518518518 1.1 1 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.48944047482117e-05 0.000213495464781982 1.20348072007397 0.518518518518518 1.1 1 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.48944047482117e-05 0.000213495464781982 1.20348072007397 0.518518518518518 1.1 1 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.000676330694937205 0.00264847456192349 1.20348072007397 0.518518518518518 1.1 1 1 GALACTOSE METABOLISM%KEGG%HSA00052 GALACTOSE METABOLISM 0.0147126160663211 0.0350471260766836 1.20348072007397 0.518518518518518 1.1 1 1 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 NICOTINE PHARMACODYNAMICS PATHWAY 0.0147126160663211 0.0350471260766836 1.20348072007397 0.518518518518518 1.1 1 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0147126160663211 0.0350471260766836 1.20348072007397 0.518518518518518 1.1 1 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0147126160663211 0.0350471260766836 1.20348072007397 0.518518518518518 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0147126160663211 0.0350471260766836 1.20348072007397 0.518518518518518 1.1 1 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.5759083334102e-06 1.58010276623677e-05 1.2026992390869 0.518181818181818 1.1 1 1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY 0.0120487402004057 0.0293375142275807 1.20051648184718 0.517241379310345 1.1 1 1 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK 0.000386597203486902 0.00162333889425949 1.19918257464513 0.516666666666667 1.1 1 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.74811007933427e-08 3.26933778666984e-07 1.19793472597224 0.516129032258065 1.1 1 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00988157651362854 0.0252742165532866 1.19793472597224 0.516129032258065 1.1 1 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.61721586761972e-11 8.5291964858264e-10 1.1969274938596 0.515695067264574 1.1 1 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.6085403107136e-07 3.43936039967589e-06 1.19620693550209 0.515384615384615 1.1 1 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.55207695913031e-09 1.70847173797171e-07 1.1960974027729 0.515337423312883 1.1 1 1 GLYCINE, SERINE AND THREONINE METABOLISM%KEGG%HSA00260 GLYCINE, SERINE AND THREONINE METABOLISM 0.00811474649899895 0.0217244533176246 1.19566591020336 0.515151515151515 1.1 1 1 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY 0.00811474649899895 0.0217244533176246 1.19566591020336 0.515151515151515 1.1 1 1 TUBERCULOSIS%KEGG%HSA05152 TUBERCULOSIS 5.18745525101699e-08 8.54957468558237e-07 1.19186411080684 0.513513513513513 1.1 1 1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-MEDIATED SIGNALING EVENTS 0.00549087069640718 0.0154364883010935 1.19186411080684 0.513513513513513 1.1 1 1 GLYCEROPHOSPHOLIPID METABOLISM%KEGG%HSA00564 GLYCEROPHOSPHOLIPID METABOLISM 8.81223010052792e-05 0.000459246062748856 1.19103872014839 0.513157894736842 1.1 1 1 PARKINSON DISEASE%PANTHER PATHWAY%P00049 PARKINSON DISEASE 7.332894117187e-05 0.000390643268424689 1.19025565721601 0.512820512820513 1.1 1 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00452341841662771 0.0129654938746166 1.19025565721601 0.512820512820513 1.1 1 1 ABC TRANSPORTERS%KEGG%HSA02010 ABC TRANSPORTERS 0.00372966266754071 0.011133616792377 1.18880412592672 0.51219512195122 1.1 1 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.22960328752902e-09 1.46649722070877e-07 1.18780513086292 0.511764705882353 1.1 1 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.15179093459994e-07 4.00267512298958e-06 1.18667594095371 0.511278195488722 1.1 1 1 MALARIA%KEGG%HSA05144 MALARIA 0.0025414534931422 0.00792176461160281 1.18628813835862 0.511111111111111 1.1 1 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.036213352139e-05 0.000131605260038984 1.18572751069399 0.510869565217391 1.1 1 1 VASCULAR SMOOTH MUSCLE CONTRACTION%KEGG%HSA04270 VASCULAR SMOOTH MUSCLE CONTRACTION 8.19083958884827e-06 5.91760109473778e-05 1.18325415335003 0.509803921568627 1.1 1 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00143661928505554 0.00497814067633569 1.18325415335003 0.509803921568627 1.1 1 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.27264715896178e-11 3.30529856942155e-09 1.18159925243626 0.509090909090909 1.1 1 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.000984862677310342 0.00366819615828725 1.18159925243626 0.509090909090909 1.1 1 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.24222339107605e-08 2.40863461931436e-07 1.18109984446819 0.50887573964497 1.1 1 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.000816023975130203 0.00310065594008407 1.18085890202746 0.508771929824561 1.1 1 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.54279906242809e-09 8.05375959277834e-08 1.17952384391324 0.508196721311475 1.1 1 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00056093505157369 0.00229331121085244 1.17952384391324 0.508196721311475 1.1 1 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000465342104783324 0.00192638481995859 1.17891988905205 0.507936507936508 1.1 1 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000386178950645097 0.00162333889425949 1.17835310064385 0.507692307692308 1.1 1 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.41654460401157e-19 6.00628541385234e-17 1.1768443258671 0.507042253521127 1.1 1 1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK P73 TRANSCRIPTION FACTOR NETWORK 0.000152729808882993 0.000730941027267611 1.17597258932942 0.506666666666667 1.1 1 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.000105585796996755 0.000533390319311195 1.17518912990948 0.506329113924051 1.1 1 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 6.07955841936084e-05 0.000333301362824419 1.17415219832426 0.505882352941176 1.1 1 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 5.05215019168396e-09 1.09200984061234e-07 1.1731133882398 0.505434782608696 1.1 1 1 NATURAL KILLER CELL MEDIATED CYTOTOXICITY%KEGG%HSA04650 NATURAL KILLER CELL MEDIATED CYTOTOXICITY 2.92030773232669e-05 0.000182053226717388 1.17297775251449 0.505376344086022 1.1 1 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.46639057157093e-09 6.19416374974528e-08 1.17258779980421 0.505208333333333 1.1 1 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 6.78945370047713e-06 5.05756762942322e-05 1.17114604804052 0.504587155963303 1.1 1 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.10766645836673e-06 1.22214077435693e-05 1.16949538412503 0.503875968992248 1.1 1 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.69719006260753e-06 2.53933599899473e-05 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 8.01728230750082e-06 5.80812457276914e-05 1.16049926578561 0.5 1.1 1 1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY 1.99394930204397e-05 0.000129190277874446 1.16049926578561 0.5 1.1 1 1 MRNA SURVEILLANCE PATHWAY%KEGG%HSA03015 MRNA SURVEILLANCE PATHWAY 0.000180617221660185 0.000852035086794112 1.16049926578561 0.5 1.1 1 1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK GLUCOCORTICOID RECEPTOR REGULATORY NETWORK 0.000180617221660185 0.000852035086794112 1.16049926578561 0.5 1.1 1 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00116637853079607 0.00426589499229542 1.16049926578561 0.5 1.1 1 1 VIBRIO CHOLERAE INFECTION%KEGG%HSA05110 VIBRIO CHOLERAE INFECTION 0.00301297543743459 0.00919585211633682 1.16049926578561 0.5 1.1 1 1 CYTOSOLIC DNA-SENSING PATHWAY%KEGG%HSA04623 CYTOSOLIC DNA-SENSING PATHWAY 0.00301297543743459 0.00919585211633682 1.16049926578561 0.5 1.1 1 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00301297543743459 0.00919585211633682 1.16049926578561 0.5 1.1 1 1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS 0.00442385832036265 0.0127354960598213 1.16049926578561 0.5 1.1 1 1 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY 0.00536682912421877 0.0151849017173443 1.16049926578561 0.5 1.1 1 1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING 0.00536682912421877 0.0151849017173443 1.16049926578561 0.5 1.1 1 1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY 0.0143192082652091 0.034389573948412 1.16049926578561 0.5 1.1 1 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0143192082652091 0.034389573948412 1.16049926578561 0.5 1.1 1 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0143192082652091 0.034389573948412 1.16049926578561 0.5 1.1 1 1 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY 0.0214040890432787 0.0482469862102863 1.16049926578561 0.5 1.1 1 1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 INTERFERON-GAMMA SIGNALING PATHWAY 0.0214040890432787 0.0482469862102863 1.16049926578561 0.5 1.1 1 1 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE 0.0214040890432787 0.0482469862102863 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0214040890432787 0.0482469862102863 1.16049926578561 0.5 1.1 1 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0214040890432787 0.0482469862102863 1.16049926578561 0.5 1.1 1 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0214040890432787 0.0482469862102863 1.16049926578561 0.5 1.1 1 1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 ADRENALINE AND NORADRENALINE BIOSYNTHESIS 0.0322410749201916 0.0663180300815486 1.16049926578561 0.5 1.1 1 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0322410749201916 0.0663180300815486 1.16049926578561 0.5 1.1 1 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0322410749201916 0.0663180300815486 1.16049926578561 0.5 1.1 1 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0397142079293025 0.0797004309814085 1.16049926578561 0.5 1.1 1 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0397142079293025 0.0797004309814085 1.16049926578561 0.5 1.1 1 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0397142079293025 0.0797004309814085 1.16049926578561 0.5 1.1 1 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0397142079293025 0.0797004309814085 1.16049926578561 0.5 1.1 1 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0397142079293025 0.0797004309814085 1.16049926578561 0.5 1.1 1 1 STEROID BIOSYNTHESIS%KEGG%HSA00100 STEROID BIOSYNTHESIS 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 OPIOID PROOPIOMELANOCORTIN PATHWAY 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0757594007145008 0.138350096734168 1.16049926578561 0.5 1.1 1 1 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7228 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%HUMANCYC%PWY-7210 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7184 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 GLYCOSAMINOGLYCAN BIOSYNTHESIS - KERATAN SULFATE%KEGG%HSA00533 GLYCOSAMINOGLYCAN BIOSYNTHESIS - KERATAN SULFATE 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK SIGNALING IN THE CD4+ TCR PATHWAY 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 CELL CYCLE%PANTHER PATHWAY%P00013 CELL CYCLE 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0948531184099409 0.163910663988869 1.16049926578561 0.5 1.1 1 1 TRIACYLGLYCEROL DEGRADATION%HUMANCYC%LIPAS-PWY TRIACYLGLYCEROL DEGRADATION 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.119582961658957 0.199204213452097 1.16049926578561 0.5 1.1 1 1 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING 8.63652791146032e-05 0.000453675778934679 1.16049926578561 0.5 1.1 1 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000217337316760709 0.000994997403295121 1.16049926578561 0.5 1.1 1 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000217337316760709 0.000994997403295121 1.16049926578561 0.5 1.1 1 1 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY 0.00963679848263036 0.0249368024245434 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00963679848263036 0.0249368024245434 1.16049926578561 0.5 1.1 1 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00963679848263036 0.0249368024245434 1.16049926578561 0.5 1.1 1 1 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA 0.0117391983893464 0.0287430512095697 1.16049926578561 0.5 1.1 1 1 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0.0174921851388692 0.040604658636618 1.16049926578561 0.5 1.1 1 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0174921851388692 0.040604658636618 1.16049926578561 0.5 1.1 1 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0174921851388692 0.040604658636618 1.16049926578561 0.5 1.1 1 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0174921851388692 0.040604658636618 1.16049926578561 0.5 1.1 1 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0174921851388692 0.040604658636618 1.16049926578561 0.5 1.1 1 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0174921851388692 0.040604658636618 1.16049926578561 0.5 1.1 1 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0262408277931396 0.0566428848257792 1.16049926578561 0.5 1.1 1 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0262408277931396 0.0566428848257792 1.16049926578561 0.5 1.1 1 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0262408277931396 0.0566428848257792 1.16049926578561 0.5 1.1 1 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0262408277931396 0.0566428848257792 1.16049926578561 0.5 1.1 1 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0262408277931396 0.0566428848257792 1.16049926578561 0.5 1.1 1 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0262408277931396 0.0566428848257792 1.16049926578561 0.5 1.1 1 1 BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY 0.0490660314650774 0.0955591764943937 1.16049926578561 0.5 1.1 1 1 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY 0.0490660314650774 0.0955591764943937 1.16049926578561 0.5 1.1 1 1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 SYNAPTIC_VESICLE_TRAFFICKING 0.0490660314650774 0.0955591764943937 1.16049926578561 0.5 1.1 1 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0490660314650774 0.0955591764943937 1.16049926578561 0.5 1.1 1 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0490660314650774 0.0955591764943937 1.16049926578561 0.5 1.1 1 1 CCR9%IOB%CCR9 CCR9 0.0608367825787413 0.114754360271918 1.16049926578561 0.5 1.1 1 1 UNTITLED%PANTHER PATHWAY%P05916 UNTITLED 0.0608367825787413 0.114754360271918 1.16049926578561 0.5 1.1 1 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0608367825787413 0.114754360271918 1.16049926578561 0.5 1.1 1 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0608367825787413 0.114754360271918 1.16049926578561 0.5 1.1 1 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0608367825787413 0.114754360271918 1.16049926578561 0.5 1.1 1 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0608367825787413 0.114754360271918 1.16049926578561 0.5 1.1 1 1 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%HUMANCYC%PWY-7197 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF AND VEGFR SIGNALING NETWORK 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 PYRIMIDINE METABOLISM 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.15215338187304 0.24405624574161 1.16049926578561 0.5 1.1 1 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.13866368726958e-11 1.47797431130891e-09 1.15157234835649 0.496153846153846 1.1 1 1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS DIRECT P53 EFFECTORS 3.15859421639211e-06 2.79598844334772e-05 1.15136147629123 0.496062992125984 1.1 1 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.41927363190546e-11 2.64494133864605e-09 1.15128895415239 0.496031746031746 1.1 1 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.41927363190546e-11 2.64494133864605e-09 1.15128895415239 0.496031746031746 1.1 1 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.41927363190546e-11 2.64494133864605e-09 1.15128895415239 0.496031746031746 1.1 1 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.53892172079602e-06 3.79972589769495e-05 1.15106431240524 0.495934959349593 1.1 1 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.44184608141459e-06 4.34852973233039e-05 1.15090836276259 0.495867768595041 1.1 1 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.09624641799668e-30 7.22700451064311e-28 1.15009786391557 0.495518565941101 1.1 1 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.9438764995893e-05 0.000126567958751036 1.1496534782549 0.495327102803738 1.1 1 1 MELANOGENESIS%KEGG%HSA04916 MELANOGENESIS 6.99106565661771e-05 0.000374704067815059 1.14802077905673 0.494623655913978 1.1 1 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.69178205723832e-21 8.85020844085222e-19 1.14745994819251 0.49438202247191 1.1 1 1 CALCIUM SIGNALING PATHWAY%KEGG%HSA04020 CALCIUM SIGNALING PATHWAY 1.42831098365144e-07 2.05817271250757e-06 1.14651734692072 0.493975903614458 1.1 1 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000175379839171647 0.000830299166778514 1.14651734692072 0.493975903614458 1.1 1 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.000253772860707028 0.00114003242535679 1.14580940166174 0.493670886075949 1.1 1 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.000442608968133327 0.00183515699523205 1.14460201556937 0.493150684931507 1.1 1 1 RNA DEGRADATION%KEGG%HSA03018 RNA DEGRADATION 0.000642293856575716 0.00257797397228335 1.14368043584669 0.492753623188406 1.1 1 1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 CYTOSKELETAL REGULATION BY RHO GTPASE 0.00112580850201752 0.00414630868689972 1.14207864251917 0.492063492063492 1.1 1 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.57911152555721e-06 5.56716353562517e-05 1.14147468765798 0.491803278688525 1.1 1 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0013584928142407 0.0048085175183258 1.14147468765798 0.491803278688525 1.1 1 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0013584928142407 0.0048085175183258 1.14147468765798 0.491803278688525 1.1 1 1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 WNT SIGNALING PATHWAY 4.33267373626738e-10 1.50332376875488e-08 1.14115761135585 0.491666666666667 1.1 1 1 P53 SIGNALING PATHWAY%KEGG%HSA04115 P53 SIGNALING PATHWAY 0.00164000100459846 0.00549514949063041 1.1408297867045 0.491525423728814 1.1 1 1 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-MEDIATED SIGNALING EVENTS 0.00164000100459846 0.00549514949063041 1.1408297867045 0.491525423728814 1.1 1 1 MEASLES%KEGG%HSA05162 MEASLES 1.56703126039473e-05 0.000107125627055981 1.14013962954376 0.491228070175439 1.1 1 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00239361384240944 0.00758649002696356 1.13939927913496 0.490909090909091 1.1 1 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00239361384240944 0.00758649002696356 1.13939927913496 0.490909090909091 1.1 1 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00239361384240944 0.00758649002696356 1.13939927913496 0.490909090909091 1.1 1 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00239361384240944 0.00758649002696356 1.13939927913496 0.490909090909091 1.1 1 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00239361384240944 0.00758649002696356 1.13939927913496 0.490909090909091 1.1 1 1 NOD-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04621 NOD-LIKE RECEPTOR SIGNALING PATHWAY 0.00289406433838897 0.00895733293466164 1.13860305322362 0.490566037735849 1.1 1 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.00248212047486e-10 3.83122514738003e-09 1.13826747908474 0.490421455938697 1.1 1 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.6129885490601e-05 0.000310302951863134 1.1372892804699 0.49 1.1 1 1 LEPTIN%IOB%LEPTIN LEPTIN 0.0042384285086095 0.0123773377377666 1.13681560730019 0.489795918367347 1.1 1 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0042384285086095 0.0123773377377666 1.13681560730019 0.489795918367347 1.1 1 1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS CASPASE CASCADE IN APOPTOSIS 0.00513440279463064 0.0146387676160301 1.13580779204549 0.48936170212766 1.1 1 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00513440279463064 0.0146387676160301 1.13580779204549 0.48936170212766 1.1 1 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.000202629781406813 0.000944054299593228 1.13351091076734 0.488372093023256 1.1 1 1 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION%KEGG%HSA00280 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION 0.00755196679329915 0.0204251655732614 1.13351091076734 0.488372093023256 1.1 1 1 PROTEASOME%KEGG%HSA03050 PROTEASOME 0.00755196679329915 0.0204251655732614 1.13351091076734 0.488372093023256 1.1 1 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.3060842447585e-11 7.32796628388969e-10 1.13277402735387 0.488054607508532 1.1 1 1 PROGESTERONE-MEDIATED OOCYTE MATURATION%KEGG%HSA04914 PROGESTERONE-MEDIATED OOCYTE MATURATION 0.000292941770451638 0.00126430024334038 1.1321944056445 0.48780487804878 1.1 1 1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY 0.0091707721380285 0.0239202038852435 1.1321944056445 0.48780487804878 1.1 1 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.50512991088302e-05 0.000103629962793695 1.13124298177421 0.487394957983193 1.1 1 1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 TRANSCRIPTION FACTOR NETWORK 0.0111473908177767 0.027601567686833 1.13074287435521 0.487179487179487 1.1 1 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0111473908177767 0.027601567686833 1.13074287435521 0.487179487179487 1.1 1 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0111473908177767 0.027601567686833 1.13074287435521 0.487179487179487 1.1 1 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0111473908177767 0.027601567686833 1.13074287435521 0.487179487179487 1.1 1 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000510147470994763 0.00210196700158311 1.12995981142283 0.486842105263158 1.1 1 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.04866164042054e-19 3.8588005327064e-17 1.12961145262782 0.486692015209125 1.1 1 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000614095961441006 0.002487513134132 1.12913442076438 0.486486486486487 1.1 1 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000614095961441006 0.002487513134132 1.12913442076438 0.486486486486487 1.1 1 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0135645195432629 0.0327261098221266 1.12913442076438 0.486486486486487 1.1 1 1 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY 2.18889229822944e-07 2.97531391259332e-06 1.12734214390602 0.485714285714286 1.1 1 1 PROTEIN DIGESTION AND ABSORPTION%KEGG%HSA04974 PROTEIN DIGESTION AND ABSORPTION 0.00089065762632373 0.00336484836764423 1.12734214390602 0.485714285714286 1.1 1 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00089065762632373 0.00336484836764423 1.12734214390602 0.485714285714286 1.1 1 1 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY PHOSPHOLIPASES 0.0165252668499343 0.038666485078329 1.12734214390602 0.485714285714286 1.1 1 1 DNA REPLICATION%KEGG%HSA03030 DNA REPLICATION 0.0165252668499343 0.038666485078329 1.12734214390602 0.485714285714286 1.1 1 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0165252668499343 0.038666485078329 1.12734214390602 0.485714285714286 1.1 1 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0165252668499343 0.038666485078329 1.12734214390602 0.485714285714286 1.1 1 1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK 0.0201587016922304 0.0458658294757649 1.12533262136786 0.484848484848485 1.1 1 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0201587016922304 0.0458658294757649 1.12533262136786 0.484848484848485 1.1 1 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00155964429013411 0.00532743781487519 1.12423366372981 0.484375 1.1 1 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.60933512830987e-16 2.54845064198264e-14 1.12407103771162 0.484304932735426 1.1 1 1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY NONCANONICAL WNT SIGNALING PATHWAY 0.0246271307250323 0.0540280729799585 1.12306380559898 0.483870967741935 1.1 1 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0246271307250323 0.0540280729799585 1.12306380559898 0.483870967741935 1.1 1 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0246271307250323 0.0540280729799585 1.12306380559898 0.483870967741935 1.1 1 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00227028299416121 0.00723910067182965 1.12181595692609 0.483333333333333 1.1 1 1 GNRH SIGNALING PATHWAY%KEGG%HSA04912 GNRH SIGNALING PATHWAY 0.00023181438141263 0.00105673580450448 1.12138131300632 0.48314606741573 1.1 1 1 PANCREATIC SECRETION%KEGG%HSA04972 PANCREATIC SECRETION 0.000278519988185053 0.00122153805692927 1.12048204972404 0.482758620689655 1.1 1 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0301357479632936 0.0631199105474228 1.12048204972404 0.482758620689655 1.1 1 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0301357479632936 0.0631199105474228 1.12048204972404 0.482758620689655 1.1 1 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0301357479632936 0.0631199105474228 1.12048204972404 0.482758620689655 1.1 1 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000334702388694995 0.00142356483707855 1.11954046816965 0.482352941176471 1.1 1 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000334702388694995 0.00142356483707855 1.11954046816965 0.482352941176471 1.1 1 1 GLUTAMATERGIC SYNAPSE%KEGG%HSA04724 GLUTAMATERGIC SYNAPSE 4.25881455145506e-05 0.000251804797582668 1.11905286343612 0.482142857142857 1.1 1 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.10612335425858e-05 0.000287096957040083 1.11829929248431 0.481818181818182 1.1 1 1 RNA POLYMERASE%KEGG%HSA03020 RNA POLYMERASE 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 SIGNALING EVENTS 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0369455958251854 0.0750004127721431 1.11751781149725 0.481481481481481 1.1 1 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.25146116840626e-06 1.34698085758666e-05 1.11698054331865 0.48125 1.1 1 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.63341279302075e-05 0.000109600751531698 1.11481031831374 0.480314960629921 1.1 1 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.0590723424023e-07 4.97849942647203e-06 1.11460381459635 0.480225988700565 1.1 1 1 HOMOLOGOUS RECOMBINATION%KEGG%HSA03440 HOMOLOGOUS RECOMBINATION 0.0453912404715525 0.0900652378656764 1.11407929515419 0.48 1.1 1 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0453912404715525 0.0900652378656764 1.11407929515419 0.48 1.1 1 1 AMYOTROPHIC LATERAL SCLEROSIS (ALS)%KEGG%HSA05014 AMYOTROPHIC LATERAL SCLEROSIS (ALS) 0.00708611596325099 0.0195256925758546 1.11214512971121 0.479166666666667 1.1 1 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00708611596325099 0.0195256925758546 1.11214512971121 0.479166666666667 1.1 1 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.8799669748139e-09 4.90838902236064e-08 1.11043851314388 0.47843137254902 1.1 1 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00146809973212266 0.00507389121049471 1.11004277596884 0.478260869565217 1.1 1 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00146809973212266 0.00507389121049471 1.11004277596884 0.478260869565217 1.1 1 1 GLYCEROLIPID METABOLISM%KEGG%HSA00561 GLYCEROLIPID METABOLISM 0.00858473620102299 0.0225253227483558 1.11004277596884 0.478260869565217 1.1 1 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00858473620102299 0.0225253227483558 1.11004277596884 0.478260869565217 1.1 1 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00858473620102299 0.0225253227483558 1.11004277596884 0.478260869565217 1.1 1 1 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 0.0559053158979323 0.107450669112863 1.11004277596884 0.478260869565217 1.1 1 1 GLYCOSYLPHOSPHATIDYLINOSITOL(GPI)-ANCHOR BIOSYNTHESIS%KEGG%HSA00563 GLYCOSYLPHOSPHATIDYLINOSITOL(GPI)-ANCHOR BIOSYNTHESIS 0.0559053158979323 0.107450669112863 1.11004277596884 0.478260869565217 1.1 1 1 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING ENDOGENOUS TLR SIGNALING 0.0559053158979323 0.107450669112863 1.11004277596884 0.478260869565217 1.1 1 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0559053158979323 0.107450669112863 1.11004277596884 0.478260869565217 1.1 1 1 PURINE METABOLISM%KEGG%HSA00230 PURINE METABOLISM 3.46438821557835e-06 2.94696507241294e-05 1.10740452813529 0.477124183006536 1.1 1 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.1323572207192e-16 1.19441039641462e-14 1.1065770776784 0.476767676767677 1.1 1 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.90467484059296e-08 1.10697358957705e-06 1.10523739598629 0.476190476190476 1.1 1 1 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION%KEGG%HSA05120 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 0.00256813679081634 0.00798605744974374 1.10523739598629 0.476190476190476 1.1 1 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00256813679081634 0.00798605744974374 1.10523739598629 0.476190476190476 1.1 1 1 VITAMIN DIGESTION AND ABSORPTION%KEGG%HSA04977 VITAMIN DIGESTION AND ABSORPTION 0.0690533523247853 0.128870268988294 1.10523739598629 0.476190476190476 1.1 1 1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY 0.0690533523247853 0.128870268988294 1.10523739598629 0.476190476190476 1.1 1 1 TRYPTOPHAN METABOLISM%KEGG%HSA00380 TRYPTOPHAN METABOLISM 0.0153371789133739 0.0364033670518155 1.10247430249633 0.475 1.1 1 1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 TRANSCRIPTION FACTOR NETWORK 0.0153371789133739 0.0364033670518155 1.10247430249633 0.475 1.1 1 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00373526944246464 0.011133616792377 1.10149082854227 0.474576271186441 1.1 1 1 CCR7%IOB%CCR7 CCR7 0.0855845078059697 0.151765400806775 1.09942035706005 0.473684210526316 1.1 1 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0855845078059697 0.151765400806775 1.09942035706005 0.473684210526316 1.1 1 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00544198981649656 0.0153208989728076 1.09719930583367 0.472727272727273 1.1 1 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00544198981649656 0.0153208989728076 1.09719930583367 0.472727272727273 1.1 1 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00544198981649656 0.0153208989728076 1.09719930583367 0.472727272727273 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00164850735349028 0.00551664199385009 1.09602708435308 0.472222222222222 1.1 1 1 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%HUMANCYC%PWY66-409 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE 0.022688633283838 0.0500668836564693 1.09602708435308 0.472222222222222 1.1 1 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.022688633283838 0.0500668836564693 1.09602708435308 0.472222222222222 1.1 1 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.82223538603675e-08 5.02853696822899e-07 1.09575037971173 0.472103004291845 1.1 1 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 9.82136128731735e-16 9.24961775523424e-14 1.09445459212301 0.471544715447154 1.1 1 1 SALIVARY SECRETION%KEGG%HSA04970 SALIVARY SECRETION 0.00198311566432172 0.00642441769879161 1.09418502202643 0.471428571428571 1.1 1 1 ARGININE AND PROLINE METABOLISM%KEGG%HSA00330 ARGININE AND PROLINE METABOLISM 0.00794374417849193 0.0214407916056123 1.09223460309234 0.470588235294118 1.1 1 1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) SIGNALING PATHWAY 0.0276427046281272 0.0586906699713134 1.09223460309234 0.470588235294118 1.1 1 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0276427046281272 0.0586906699713134 1.09223460309234 0.470588235294118 1.1 1 1 SUPERPATHWAY OF METHIONINE DEGRADATION%HUMANCYC%PWY-5328 SUPERPATHWAY OF METHIONINE DEGRADATION 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.106507856436247 0.17934943641276 1.09223460309234 0.470588235294118 1.1 1 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0337223564248763 0.0688280602882343 1.08796806167401 0.46875 1.1 1 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0337223564248763 0.0688280602882343 1.08796806167401 0.46875 1.1 1 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00416456534193699 0.0121886335257357 1.08562834541234 0.467741935483871 1.1 1 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.09154093011099e-07 3.97677728424521e-06 1.08313264806657 0.466666666666667 1.1 1 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.09154093011099e-07 3.97677728424521e-06 1.08313264806657 0.466666666666667 1.1 1 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00501713258473011 0.0143650147947158 1.08313264806657 0.466666666666667 1.1 1 1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING AMB2 INTEGRIN SIGNALING 0.041198865434665 0.08199351558582 1.08313264806657 0.466666666666667 1.1 1 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.041198865434665 0.08199351558582 1.08313264806657 0.466666666666667 1.1 1 1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%HUMANCYC%PWY66-391 FATTY ACID &BETA;-OXIDATION (PEROXISOME) 0.133211691378176 0.217375761240253 1.08313264806657 0.466666666666667 1.1 1 1 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY 0.133211691378176 0.217375761240253 1.08313264806657 0.466666666666667 1.1 1 1 SA_MMP_CYTOKINE_CONNECTION%MSIGDB_C2%SA_MMP_CYTOKINE_CONNECTION SA_MMP_CYTOKINE_CONNECTION 0.133211691378176 0.217375761240253 1.08313264806657 0.466666666666667 1.1 1 1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-MEDIATED SIGNALING EVENTS 0.133211691378176 0.217375761240253 1.08313264806657 0.466666666666667 1.1 1 1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ERBB RECEPTOR SIGNALING NETWORK 0.133211691378176 0.217375761240253 1.08313264806657 0.466666666666667 1.1 1 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.133211691378176 0.217375761240253 1.08313264806657 0.466666666666667 1.1 1 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 5.45454503940146e-17 5.99318136204235e-15 1.08123574325384 0.46584938704028 1.1 1 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00604627915480525 0.0169617426927888 1.08046483366246 0.46551724137931 1.1 1 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0170436285482207 0.0397734942315557 1.0795342007308 0.465116279069767 1.1 1 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0170436285482207 0.0397734942315557 1.0795342007308 0.465116279069767 1.1 1 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.000165155298006498 0.000788975581237563 1.0790607208182 0.464912280701754 1.1 1 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00264649214497638 0.0082103526897679 1.07877396537817 0.464788732394366 1.1 1 1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-BETA SIGNALING PATHWAY 0.00117283802404785 0.00426589499229542 1.07760646108664 0.464285714285714 1.1 1 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00117283802404785 0.00426589499229542 1.07760646108664 0.464285714285714 1.1 1 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00117283802404785 0.00426589499229542 1.07760646108664 0.464285714285714 1.1 1 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00728913038725041 0.0199781711186576 1.07760646108664 0.464285714285714 1.1 1 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0504149017028378 0.0979691199634364 1.07760646108664 0.464285714285714 1.1 1 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00140627911298146 0.00491173247805577 1.07558468536227 0.463414634146341 1.1 1 1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS 0.0206627120375359 0.0469315862557986 1.07558468536227 0.463414634146341 1.1 1 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00879077047440703 0.0230430037186991 1.0745363572089 0.462962962962963 1.1 1 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.02189468121656e-27 5.38947254873614e-25 1.07337469628219 0.462462462462462 1.1 1 1 BETA-ALANINE METABOLISM%KEGG%HSA00410 BETA-ALANINE METABOLISM 0.0618058799101924 0.116249718490141 1.07123009149441 0.461538461538462 1.1 1 1 COLLECTING DUCT ACID SECRETION%KEGG%HSA04966 COLLECTING DUCT ACID SECRETION 0.0618058799101924 0.116249718490141 1.07123009149441 0.461538461538462 1.1 1 1 BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY 0.0618058799101924 0.116249718490141 1.07123009149441 0.461538461538462 1.1 1 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0618058799101924 0.116249718490141 1.07123009149441 0.461538461538462 1.1 1 1 L-KYNURENINE DEGRADATION%HUMANCYC%PWY-6309 L-KYNURENINE DEGRADATION 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 PATHWAY 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 HYPOXIA RESPONSE VIA HIF ACTIVATION 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.167659421495612 0.262384507112124 1.07123009149441 0.461538461538462 1.1 1 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00552622498848109 0.0155193347120603 1.06839614945342 0.46031746031746 1.1 1 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.000576648613175972 0.00235026644968321 1.06765932452276 0.46 1.1 1 1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS 0.0128014431561703 0.0310841672217505 1.06765932452276 0.46 1.1 1 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0128014431561703 0.0310841672217505 1.06765932452276 0.46 1.1 1 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00128963886755146 0.00463953300645732 1.06712576164194 0.459770114942529 1.1 1 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00128963886755146 0.00463953300645732 1.06712576164194 0.459770114942529 1.1 1 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00349094081469535 0.0105448006052138 1.06379099363681 0.458333333333333 1.1 1 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0154582642132153 0.0366248362356232 1.06379099363681 0.458333333333333 1.1 1 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0759289044175591 0.138372163751972 1.06379099363681 0.458333333333333 1.1 1 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0759289044175591 0.138372163751972 1.06379099363681 0.458333333333333 1.1 1 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0759289044175591 0.138372163751972 1.06379099363681 0.458333333333333 1.1 1 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.66301022479609e-05 0.000167198999113983 1.06316706930036 0.458064516129032 1.1 1 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00184894469608333 0.00599713058249905 1.0626258337314 0.457831325301205 1.1 1 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00799619359959263 0.0215175527229413 1.06215187038005 0.457627118644068 1.1 1 1 INFLUENZA A%KEGG%HSA05164 INFLUENZA A 6.95892716231984e-05 0.000374704067815059 1.06102790014684 0.457142857142857 1.1 1 1 CYSTEINE AND METHIONINE METABOLISM%KEGG%HSA00270 CYSTEINE AND METHIONINE METABOLISM 0.0370047574939738 0.0750050311388232 1.06102790014684 0.457142857142857 1.1 1 1 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY 0.0370047574939738 0.0750050311388232 1.06102790014684 0.457142857142857 1.1 1 1 CELL ADHESION MOLECULES (CAMS)%KEGG%HSA04514 CELL ADHESION MOLECULES (CAMS) 0.000283953224728154 0.00123970969140421 1.06045622563168 0.456896551724138 1.1 1 1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-MEDIATED SIGNALING EVENTS 0.0186753333880692 0.0425642646018483 1.05958628615208 0.456521739130435 1.1 1 1 VIRAL MYOCARDITIS%KEGG%HSA05416 VIRAL MYOCARDITIS 0.00962205167958597 0.0249368024245434 1.05870108457635 0.456140350877193 1.1 1 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00140878527760715 0.00491397721832017 1.05734377549356 0.455555555555556 1.1 1 1 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM%KEGG%HSA04141 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM 3.45760406783723e-05 0.000213030418852495 1.05635189577921 0.455128205128205 1.1 1 1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 INTERLEUKIN SIGNALING PATHWAY 0.00168431723004201 0.0056151005507216 1.05499933253237 0.454545454545455 1.1 1 1 BASAL CELL CARCINOMA%KEGG%HSA05217 BASAL CELL CARCINOMA 0.0115814210226658 0.0283830922274811 1.05499933253237 0.454545454545455 1.1 1 1 RIG-I-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04622 RIG-I-LIKE RECEPTOR SIGNALING PATHWAY 0.0115814210226658 0.0283830922274811 1.05499933253237 0.454545454545455 1.1 1 1 PHOTOTRANSDUCTION%KEGG%HSA04744 PHOTOTRANSDUCTION 0.093502639321021 0.162642783568293 1.05499933253237 0.454545454545455 1.1 1 1 ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY 0.093502639321021 0.162642783568293 1.05499933253237 0.454545454545455 1.1 1 1 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE 0.093502639321021 0.162642783568293 1.05499933253237 0.454545454545455 1.1 1 1 FOLATE TRANSFORMATIONS%HUMANCYC%PWY-2201 FOLATE TRANSFORMATIONS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%HUMANCYC%PWY-7224 PURINE DEOXYRIBONUCLEOSIDES SALVAGE 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7221 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 VALINE, LEUCINE AND ISOLEUCINE BIOSYNTHESIS%KEGG%HSA00290 VALINE, LEUCINE AND ISOLEUCINE BIOSYNTHESIS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.212731691187723 0.31990995910941 1.05499933253237 0.454545454545455 1.1 1 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000898889589387337 0.00338141490330158 1.05499933253237 0.454545454545455 1.1 1 1 PRION DISEASES%KEGG%HSA05020 PRION DISEASES 0.0450254020354148 0.0894739903296073 1.05499933253237 0.454545454545455 1.1 1 1 HEDGEHOG SIGNALING PATHWAY%KEGG%HSA04340 HEDGEHOG SIGNALING PATHWAY 0.0139434288150738 0.0335788326806845 1.05101820297565 0.452830188679245 1.1 1 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0139434288150738 0.0335788326806845 1.05101820297565 0.452830188679245 1.1 1 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.46597295564104e-05 0.000258689591970936 1.04962353975514 0.452229299363057 1.1 1 1 PYRIMIDINE METABOLISM%KEGG%HSA00240 PYRIMIDINE METABOLISM 0.00152980293431257 0.00524589120647888 1.04819288522571 0.451612903225806 1.1 1 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00152980293431257 0.00524589120647888 1.04819288522571 0.451612903225806 1.1 1 1 ALANINE, ASPARTATE AND GLUTAMATE METABOLISM%KEGG%HSA00250 ALANINE, ASPARTATE AND GLUTAMATE METABOLISM 0.0548461763720094 0.105800561150687 1.04819288522571 0.451612903225806 1.1 1 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0548461763720094 0.105800561150687 1.04819288522571 0.451612903225806 1.1 1 1 TGF-BETA SIGNALING PATHWAY%KEGG%HSA04350 TGF-BETA SIGNALING PATHWAY 0.0028781487006543 0.00891854068581127 1.04727982522116 0.451219512195122 1.1 1 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.60838672912693e-37 4.05077193490257e-34 1.04587280505921 0.450613298902518 1.1 1 1 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0.0330335959359395 0.0678423617469412 1.04444933920705 0.45 1.1 1 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0330335959359395 0.0678423617469412 1.04444933920705 0.45 1.1 1 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.11546326117579 0.193564284628455 1.04444933920705 0.45 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.11546326117579 0.193564284628455 1.04444933920705 0.45 1.1 1 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0202274080122622 0.045982478386496 1.04208097335851 0.448979591836735 1.1 1 1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-MEDIATED SIGNALING EVENTS 0.0125273668559702 0.030474784501101 1.04044761760089 0.448275862068966 1.1 1 1 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY 0.0668917141162175 0.125101737676926 1.04044761760089 0.448275862068966 1.1 1 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0668917141162175 0.125101737676926 1.04044761760089 0.448275862068966 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00782328382743292 0.0211372945214556 1.03925307383786 0.447761194029851 1.1 1 1 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY 0.0150429457286459 0.0357693849291606 1.03616005873715 0.446428571428571 1.1 1 1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 SIGNALING 0.0150429457286459 0.0357693849291606 1.03616005873715 0.446428571428571 1.1 1 1 PHAGOSOME%KEGG%HSA04145 PHAGOSOME 0.000327649032528098 0.00140489511996194 1.03552242177793 0.446153846153846 1.1 1 1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING P75(NTR)-MEDIATED SIGNALING 0.00936997898885471 0.0244156468316303 1.03552242177793 0.446153846153846 1.1 1 1 LONG-TERM DEPRESSION%KEGG%HSA04730 LONG-TERM DEPRESSION 0.0112224187489087 0.0277612741471596 1.03155490292054 0.444444444444444 1.1 1 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0180655554876072 0.0414611573723412 1.03155490292054 0.444444444444444 1.1 1 1 N-GLYCAN BIOSYNTHESIS%KEGG%HSA00510 N-GLYCAN BIOSYNTHESIS 0.0293768703293194 0.0616773941547892 1.03155490292054 0.444444444444444 1.1 1 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0293768703293194 0.0616773941547892 1.03155490292054 0.444444444444444 1.1 1 1 PENTOSE PHOSPHATE PATHWAY%KEGG%HSA00030 PENTOSE PHOSPHATE PATHWAY 0.0816941071781977 0.147250417381345 1.03155490292054 0.444444444444444 1.1 1 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0816941071781977 0.147250417381345 1.03155490292054 0.444444444444444 1.1 1 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00702414124895317 0.0193954559931827 1.03155490292054 0.444444444444444 1.1 1 1 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY 0.0484576568620824 0.0947241224205421 1.03155490292054 0.444444444444444 1.1 1 1 GLYOXYLATE AND DICARBOXYLATE METABOLISM%KEGG%HSA00630 GLYOXYLATE AND DICARBOXYLATE METABOLISM 0.143044715522251 0.232271499280896 1.03155490292054 0.444444444444444 1.1 1 1 ONE CARBON POOL BY FOLATE%KEGG%HSA00670 ONE CARBON POOL BY FOLATE 0.143044715522251 0.232271499280896 1.03155490292054 0.444444444444444 1.1 1 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.143044715522251 0.232271499280896 1.03155490292054 0.444444444444444 1.1 1 1 METABOLIC PATHWAYS%KEGG%HSA01100 METABOLIC PATHWAYS 2.8353384040701e-23 9.34598421441607e-21 1.03130740894191 0.444337811900192 1.1 1 1 PPAR SIGNALING PATHWAY%KEGG%HSA03320 PPAR SIGNALING PATHWAY 0.00839463455290598 0.0222927002175358 1.02787077826725 0.442857142857143 1.1 1 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.26659388165655e-05 0.000144034759789609 1.02752539158101 0.442708333333333 1.1 1 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0216975988925327 0.0486535444554495 1.02659550434881 0.442307692307692 1.1 1 1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 CADHERIN SIGNALING PATHWAY 0.00121013297222114 0.00438340748316914 1.02458493736027 0.441441441441441 1.1 1 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0587485841990627 0.11150266341892 1.02396994039907 0.441176470588235 1.1 1 1 LYSOSOME%KEGG%HSA04142 LYSOSOME 0.00091696451392496 0.00343959519661468 1.02281291221783 0.440677966101695 1.1 1 1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY 0.00091696451392496 0.00343959519661468 1.02281291221783 0.440677966101695 1.1 1 1 GLUCONEOGENESIS%HUMANCYC%PWY66-399 GLUCONEOGENESIS 0.0999227832322783 0.169946837182867 1.02123935389134 0.44 1.1 1 1 MATURITY ONSET DIABETES OF THE YOUNG%KEGG%HSA04950 MATURITY ONSET DIABETES OF THE YOUNG 0.0999227832322783 0.169946837182867 1.02123935389134 0.44 1.1 1 1 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.0999227832322783 0.169946837182867 1.02123935389134 0.44 1.1 1 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0999227832322783 0.169946837182867 1.02123935389134 0.44 1.1 1 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.0999227832322783 0.169946837182867 1.02123935389134 0.44 1.1 1 1 RNA TRANSPORT%KEGG%HSA03013 RNA TRANSPORT 0.000527702404919532 0.00216752529871154 1.01983268811463 0.439393939393939 1.1 1 1 STAPHYLOCOCCUS AUREUS INFECTION%KEGG%HSA05150 STAPHYLOCOCCUS AUREUS INFECTION 0.0427151572477337 0.0849471113591809 1.01897496508005 0.439024390243902 1.1 1 1 SPLICEOSOME%KEGG%HSA03040 SPLICEOSOME 0.00152950729803448 0.00524589120647888 1.01543685756241 0.4375 1.1 1 1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.177896806338811 0.27709030024539 1.01543685756241 0.4375 1.1 1 1 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 UBIQUITIN PROTEASOME PATHWAY 0.0515302387586581 0.0995496260854076 1.01171730863361 0.435897435897436 1.1 1 1 MUCIN TYPE O-GLYCAN BIOSYNTHESIS%KEGG%HSA00512 MUCIN TYPE O-GLYCAN BIOSYNTHESIS 0.122423657338782 0.203422296409809 1.00912979633531 0.434782608695652 1.1 1 1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY 0.122423657338782 0.203422296409809 1.00912979633531 0.434782608695652 1.1 1 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.122423657338782 0.203422296409809 1.00912979633531 0.434782608695652 1.1 1 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00122663867611143 0.00443710039630433 1.00830264076455 0.434426229508197 1.1 1 1 AFRICAN TRYPANOSOMIASIS%KEGG%HSA05143 AFRICAN TRYPANOSOMIASIS 0.0865391866374049 0.153156936350897 1.00576603034753 0.433333333333333 1.1 1 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0865391866374049 0.153156936350897 1.00576603034753 0.433333333333333 1.1 1 1 PEROXISOME%KEGG%HSA04146 PEROXISOME 0.0112953580978654 0.0279155194977237 1.00367504067945 0.432432432432432 1.1 1 1 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-MEDIATED SIGNALING EVENTS 0.062182248784944 0.116874262327796 1.00367504067945 0.432432432432432 1.1 1 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.99406570393662e-17 5.72580489620908e-15 1.00296542880114 0.432126696832579 1.1 1 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00632107901272557 0.0175644735053291 1.00224936590575 0.431818181818182 1.1 1 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.024392149771522 0.053646454501671 1.00043040153932 0.431034482758621 1.1 1 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.024392149771522 0.053646454501671 1.00043040153932 0.431034482758621 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.024392149771522 0.053646454501671 1.00043040153932 0.431034482758621 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0134332245419962 0.0324390230011391 0.999318812204275 0.430555555555556 1.1 1 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000220345960407493 0.00100702304609109 0.998569135675989 0.430232558139535 1.1 1 1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS 0.0396162652847559 0.0797004309814085 0.994713656387665 0.428571428571429 1.1 1 1 RHEUMATOID ARTHRITIS%KEGG%HSA05323 RHEUMATOID ARTHRITIS 0.011895454036021 0.028991046481504 0.994713656387665 0.428571428571429 1.1 1 1 OTHER TYPES OF O-GLYCAN BIOSYNTHESIS%KEGG%HSA00514 OTHER TYPES OF O-GLYCAN BIOSYNTHESIS 0.0750564542278792 0.138350096734168 0.994713656387665 0.428571428571429 1.1 1 1 HISTIDINE METABOLISM%KEGG%HSA00340 HISTIDINE METABOLISM 0.105153511284718 0.178092363042904 0.994713656387665 0.428571428571429 1.1 1 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.105153511284718 0.178092363042904 0.994713656387665 0.428571428571429 1.1 1 1 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY 0.150270692814044 0.242957582434479 0.994713656387665 0.428571428571429 1.1 1 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.150270692814044 0.242957582434479 0.994713656387665 0.428571428571429 1.1 1 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.150270692814044 0.242957582434479 0.994713656387665 0.428571428571429 1.1 1 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.150270692814044 0.242957582434479 0.994713656387665 0.428571428571429 1.1 1 1 SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 GENERAL TRANSCRIPTION BY RNA POLYMERASE I 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.222264148809865 0.324894989141693 0.994713656387665 0.428571428571429 1.1 1 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.00143619375782141 0.00497814067633569 0.99218257838159 0.427480916030534 1.1 1 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.00143619375782141 0.00497814067633569 0.99218257838159 0.427480916030534 1.1 1 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.000422009769905391 0.00175250356415829 0.990670104938935 0.426829268292683 1.1 1 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0256193169274443 0.0560713961045005 0.989278062636913 0.426229508196721 1.1 1 1 JAK-STAT SIGNALING PATHWAY%KEGG%HSA04630 JAK-STAT SIGNALING PATHWAY 0.0015058204601517 0.00518387539610971 0.987290420145966 0.425373134328358 1.1 1 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0167406155977205 0.0391356412510541 0.985629513406956 0.424657534246575 1.1 1 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.14857561355686e-05 0.000138527968042773 0.983011142783105 0.423529411764706 1.1 1 1 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY 0.127875179001808 0.209575417667973 0.981960917203208 0.423076923076923 1.1 1 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.127875179001808 0.209575417667973 0.981960917203208 0.423076923076923 1.1 1 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.000326692611730906 0.00140307559793876 0.97858316466246 0.421621621621622 1.1 1 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.184833957497728 0.287725587911162 0.977262539608934 0.421052631578947 1.1 1 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0153918949724692 0.0365003840309365 0.974246297202734 0.419753086419753 1.1 1 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.109428582940191 0.184032635977859 0.973321964852447 0.419354838709677 1.1 1 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0678552005896511 0.126813723568327 0.971580780657719 0.418604651162791 1.1 1 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0278455873253837 0.0590738646637463 0.969969535582002 0.417910447761194 1.1 1 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00698751873397903 0.0193145565005269 0.967082721488008 0.416666666666667 1.1 1 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0589176397289481 0.111613373538244 0.967082721488008 0.416666666666667 1.1 1 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0940555952034483 0.163496772940998 0.967082721488008 0.416666666666667 1.1 1 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.155634195139655 0.249336192334915 0.967082721488008 0.416666666666667 1.1 1 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.155634195139655 0.249336192334915 0.967082721488008 0.416666666666667 1.1 1 1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL) 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 CHOLESTEROL BIOSYNTHESIS I 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL) 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.279266497993985 0.394021270845447 0.967082721488008 0.416666666666667 1.1 1 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.081129617233669 0.146433128436129 0.962365244797822 0.414634146341463 1.1 1 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.081129617233669 0.146433128436129 0.962365244797822 0.414634146341463 1.1 1 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.081129617233669 0.146433128436129 0.962365244797822 0.414634146341463 1.1 1 1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 SIGNALING MEDIATED BY STAT4 0.132161838697777 0.216466315929216 0.960413185477746 0.413793103448276 1.1 1 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00962292755034195 0.0249368024245434 0.959643623630408 0.413461538461538 1.1 1 1 HEMATOPOIETIC CELL LINEAGE%KEGG%HSA04640 HEMATOPOIETIC CELL LINEAGE 0.025282171656278 0.0554190246530384 0.959346059716104 0.413333333333333 1.1 1 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0128134505586244 0.031084700205237 0.957112796524214 0.412371134020619 1.1 1 1 PRIMARY IMMUNODEFICIENCY%KEGG%HSA05340 PRIMARY IMMUNODEFICIENCY 0.112926970168732 0.18955341841817 0.955705277705796 0.411764705882353 1.1 1 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.112926970168732 0.18955341841817 0.955705277705796 0.411764705882353 1.1 1 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.112926970168732 0.18955341841817 0.955705277705796 0.411764705882353 1.1 1 1 OTHER GLYCAN DEGRADATION%KEGG%HSA00511 OTHER GLYCAN DEGRADATION 0.227869071270607 0.332351073529087 0.955705277705796 0.411764705882353 1.1 1 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.227869071270607 0.332351073529087 0.955705277705796 0.411764705882353 1.1 1 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.227869071270607 0.332351073529087 0.955705277705796 0.411764705882353 1.1 1 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.227869071270607 0.332351073529087 0.955705277705796 0.411764705882353 1.1 1 1 FATTY ACID METABOLISM%KEGG%HSA00071 FATTY ACID METABOLISM 0.0969519920201148 0.167427899775405 0.952204525772808 0.41025641025641 1.1 1 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.000168114985016487 0.000801662234156376 0.950770482812307 0.409638554216867 1.1 1 1 MISMATCH REPAIR%KEGG%HSA03430 MISMATCH REPAIR 0.189571652924599 0.2944054468564 0.949499399279135 0.409090909090909 1.1 1 1 REGULATION OF AUTOPHAGY%KEGG%HSA04140 REGULATION OF AUTOPHAGY 0.189571652924599 0.2944054468564 0.949499399279135 0.409090909090909 1.1 1 1 NITROGEN METABOLISM%KEGG%HSA00910 NITROGEN METABOLISM 0.189571652924599 0.2944054468564 0.949499399279135 0.409090909090909 1.1 1 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.189571652924599 0.2944054468564 0.949499399279135 0.409090909090909 1.1 1 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00216976046734522 0.00696065492991403 0.948212814727266 0.408536585365854 1.1 1 1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY 0.15962466588054 0.255418837334336 0.94559199434383 0.407407407407407 1.1 1 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.15962466588054 0.255418837334336 0.94559199434383 0.407407407407407 1.1 1 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0473207599206216 0.0938231909102852 0.942905653450808 0.40625 1.1 1 1 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR SIGNALING PATHWAY 0.115787422306974 0.193984391755712 0.940945350636981 0.405405405405405 1.1 1 1 FAT DIGESTION AND ABSORPTION%KEGG%HSA04975 FAT DIGESTION AND ABSORPTION 0.099389382001885 0.169946837182867 0.93945178658835 0.404761904761905 1.1 1 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.099389382001885 0.169946837182867 0.93945178658835 0.404761904761905 1.1 1 1 RIBOSOME%KEGG%HSA03010 RIBOSOME 0.0856378143346536 0.151765400806775 0.938276002124535 0.404255319148936 1.1 1 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0740184678963351 0.136589712975952 0.937326330057607 0.403846153846154 1.1 1 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0740184678963351 0.136589712975952 0.937326330057607 0.403846153846154 1.1 1 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.049513714042509 0.0963598995794067 0.928399412628487 0.4 1.1 1 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.162576940071358 0.259335623103504 0.928399412628487 0.4 1.1 1 1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7211 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.231081088379019 0.336663442019599 0.928399412628487 0.4 1.1 1 1 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY 0.231081088379019 0.336663442019599 0.928399412628487 0.4 1.1 1 1 BILE ACID BIOSYNTHESIS, NEUTRAL PATHWAY%HUMANCYC%PWY-6061 BILE ACID BIOSYNTHESIS, NEUTRAL PATHWAY 0.281632453764325 0.396180021957035 0.928399412628487 0.4 1.1 1 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.281632453764325 0.396180021957035 0.928399412628487 0.4 1.1 1 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.00765991277664e-08 8.3051567232654e-07 0.927677484624888 0.399688958009331 1.1 1 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.103144135628047 0.174913881447691 0.918728585413607 0.395833333333333 1.1 1 1 SYSTEMIC LUPUS ERYTHEMATOSUS%KEGG%HSA05322 SYSTEMIC LUPUS ERYTHEMATOSUS 0.0303976559410003 0.0636179513622363 0.914332754861389 0.393939393939394 1.1 1 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.164727784868551 0.259335623103504 0.914332754861389 0.393939393939394 1.1 1 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000620803109264491 0.00251082484529212 0.91331711170131 0.393501805054152 1.1 1 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.078126291912997 0.142278336860893 0.913179750126381 0.39344262295082 1.1 1 1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING ALPHA-SYNUCLEIN SIGNALING 0.194870707089602 0.299844974567624 0.911820851688693 0.392857142857143 1.1 1 1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS BETA2 INTEGRIN CELL SURFACE INTERACTIONS 0.194870707089602 0.299844974567624 0.911820851688693 0.392857142857143 1.1 1 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000248691600536657 0.00111911220241495 0.911312306874589 0.392638036809816 1.1 1 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.121524021473658 0.202309876657851 0.908216816701781 0.391304347826087 1.1 1 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.232738221515482 0.33889049703828 0.908216816701781 0.391304347826087 1.1 1 1 TASTE TRANSDUCTION%KEGG%HSA04742 TASTE TRANSDUCTION 0.141791996843579 0.230663476666575 0.905755524515598 0.390243902439024 1.1 1 1 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY 0.281848206746833 0.396180021957035 0.902610540055474 0.388888888888889 1.1 1 1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS SYNDECAN-3-MEDIATED SIGNALING EVENTS 0.281848206746833 0.396180021957035 0.902610540055474 0.388888888888889 1.1 1 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.281848206746833 0.396180021957035 0.902610540055474 0.388888888888889 1.1 1 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.0320166812918773 0.0662536428204753 0.899125557275337 0.387387387387387 1.1 1 1 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS SIGNALING PATHWAY 0.196144323522621 0.299844974567624 0.898451044479181 0.387096774193548 1.1 1 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0807700651881784 0.146084130247755 0.895242290748899 0.385714285714286 1.1 1 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.16726961605612 0.262384507112124 0.892691742912007 0.384615384615385 1.1 1 1 GLYCOSAMINOGLYCAN BIOSYNTHESIS - HEPARAN SULFATE%KEGG%HSA00534 GLYCOSAMINOGLYCAN BIOSYNTHESIS - HEPARAN SULFATE 0.233337609792133 0.339388459471514 0.892691742912007 0.384615384615385 1.1 1 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.233337609792133 0.339388459471514 0.892691742912007 0.384615384615385 1.1 1 1 STEARATE BIOSYNTHESIS%HUMANCYC%PWY-5972 STEARATE BIOSYNTHESIS 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 NON-HOMOLOGOUS END-JOINING%KEGG%HSA03450 NON-HOMOLOGOUS END-JOINING 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 TERPENOID BACKBONE BIOSYNTHESIS%KEGG%HSA00900 TERPENOID BACKBONE BIOSYNTHESIS 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.349020920805469 0.462879495351277 0.892691742912007 0.384615384615385 1.1 1 1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS SYNDECAN-2-MEDIATED SIGNALING EVENTS 0.1967949558732 0.300317302452332 0.887440615012525 0.382352941176471 1.1 1 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.1967949558732 0.300317302452332 0.887440615012525 0.382352941176471 1.1 1 1 COMPLEMENT AND COAGULATION CASCADES%KEGG%HSA04610 COMPLEMENT AND COAGULATION CASCADES 0.108022900641427 0.181784549452102 0.884189916789036 0.380952380952381 1.1 1 1 GLYCOSAMINOGLYCAN BIOSYNTHESIS - CHONDROITIN SULFATE%KEGG%HSA00532 GLYCOSAMINOGLYCAN BIOSYNTHESIS - CHONDROITIN SULFATE 0.280810562572851 0.395776297971464 0.884189916789036 0.380952380952381 1.1 1 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.280810562572851 0.395776297971464 0.884189916789036 0.380952380952381 1.1 1 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.124849168116022 0.207061167498082 0.8803787533546 0.379310344827586 1.1 1 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.124849168116022 0.207061167498082 0.8803787533546 0.379310344827586 1.1 1 1 OXIDATIVE PHOSPHORYLATION%KEGG%HSA00190 OXIDATIVE PHOSPHORYLATION 0.0557984980694756 0.107450669112863 0.878824686711432 0.378640776699029 1.1 1 1 DRUG METABOLISM - CYTOCHROME P450%KEGG%HSA00982 DRUG METABOLISM - CYTOCHROME P450 0.14468099855348 0.234495263174878 0.875848502479705 0.377358490566038 1.1 1 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.14468099855348 0.234495263174878 0.875848502479705 0.377358490566038 1.1 1 1 TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY TRIACYLGLYCEROL BIOSYNTHESIS 0.279000637340978 0.394021270845447 0.870374449339207 0.375 1.1 1 1 PENTOSE AND GLUCURONATE INTERCONVERSIONS%KEGG%HSA00040 PENTOSE AND GLUCURONATE INTERCONVERSIONS 0.279000637340978 0.394021270845447 0.870374449339207 0.375 1.1 1 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.279000637340978 0.394021270845447 0.870374449339207 0.375 1.1 1 1 RETINOL BIOSYNTHESIS%HUMANCYC%PWY-6857 RETINOL BIOSYNTHESIS 0.343873842219633 0.462879495351277 0.870374449339207 0.375 1.1 1 1 FATTY ACID &BETA;-OXIDATION%HUMANCYC%FAO-PWY FATTY ACID &BETA;-OXIDATION 0.343873842219633 0.462879495351277 0.870374449339207 0.375 1.1 1 1 RENIN-ANGIOTENSIN SYSTEM%KEGG%HSA04614 RENIN-ANGIOTENSIN SYSTEM 0.343873842219633 0.462879495351277 0.870374449339207 0.375 1.1 1 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.343873842219633 0.462879495351277 0.870374449339207 0.375 1.1 1 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.343873842219633 0.462879495351277 0.870374449339207 0.375 1.1 1 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.343873842219633 0.462879495351277 0.870374449339207 0.375 1.1 1 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.167984770318489 0.262737745747245 0.864685727448101 0.372549019607843 1.1 1 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.19625807866851 0.299845048348124 0.86362736058464 0.372093023255814 1.1 1 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.0566732213279441 0.108688934284937 0.861015584292549 0.370967741935484 1.1 1 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.0566732213279441 0.108688934284937 0.861015584292549 0.370967741935484 1.1 1 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.0566732213279441 0.108688934284937 0.861015584292549 0.370967741935484 1.1 1 1 STARCH AND SUCROSE METABOLISM%KEGG%HSA00500 STARCH AND SUCROSE METABOLISM 0.195519438621691 0.299844974567624 0.857760326885016 0.369565217391304 1.1 1 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.0499811213233567 0.0971978000956427 0.855971089657471 0.368794326241135 1.1 1 1 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY 0.338439852142144 0.461461163443037 0.855104722157817 0.368421052631579 1.1 1 1 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY 0.338439852142144 0.461461163443037 0.855104722157817 0.368421052631579 1.1 1 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.194590807265621 0.299844974567624 0.852611705475142 0.36734693877551 1.1 1 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.12454756489344 0.206821113743074 0.852012119184371 0.367088607594937 1.1 1 1 METABOLISM OF XENOBIOTICS BY CYTOCHROME P450%KEGG%HSA00980 METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 0.19350888565734 0.299844974567624 0.848057155766407 0.365384615384615 1.1 1 1 CYTOKINE-CYTOKINE RECEPTOR INTERACTION%KEGG%HSA04060 CYTOKINE-CYTOKINE RECEPTOR INTERACTION 0.0239306821265648 0.0527635524813975 0.846850815573282 0.364864864864865 1.1 1 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.192302877729346 0.298471270495754 0.843999466025898 0.363636363636364 1.1 1 1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS 0.332947082371852 0.454441747523071 0.843999466025898 0.363636363636364 1.1 1 1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY 0.332947082371852 0.454441747523071 0.843999466025898 0.363636363636364 1.1 1 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.332947082371852 0.454441747523071 0.843999466025898 0.363636363636364 1.1 1 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.332947082371852 0.454441747523071 0.843999466025898 0.363636363636364 1.1 1 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.164704412494512 0.259335623103504 0.843999466025898 0.363636363636364 1.1 1 1 ETHER LIPID METABOLISM%KEGG%HSA00565 ETHER LIPID METABOLISM 0.271244347891053 0.388115988805335 0.843999466025898 0.363636363636364 1.1 1 1 TYPE I DIABETES MELLITUS%KEGG%HSA04940 TYPE I DIABETES MELLITUS 0.271244347891053 0.388115988805335 0.843999466025898 0.363636363636364 1.1 1 1 PORPHYRIN AND CHLOROPHYLL METABOLISM%KEGG%HSA00860 PORPHYRIN AND CHLOROPHYLL METABOLISM 0.268278491506395 0.384483903316502 0.83813835862294 0.361111111111111 1.1 1 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.139715550680904 0.22742586860836 0.836639005566369 0.36046511627907 1.1 1 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.327502481613956 0.448170235607681 0.835559471365639 0.36 1.1 1 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.137024620998996 0.223183400601823 0.830673158667594 0.357894736842105 1.1 1 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.137024620998996 0.223183400601823 0.830673158667594 0.357894736842105 1.1 1 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.137024620998996 0.223183400601823 0.830673158667594 0.357894736842105 1.1 1 1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK WNT SIGNALING NETWORK 0.322157863892382 0.441085299628355 0.828928046989721 0.357142857142857 1.1 1 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.322157863892382 0.441085299628355 0.828928046989721 0.357142857142857 1.1 1 1 THE VISUAL CYCLE I (VERTEBRATES)%HUMANCYC%PWY-6861 THE VISUAL CYCLE I (VERTEBRATES) 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.419441349691916 0.540335534507856 0.828928046989721 0.357142857142857 1.1 1 1 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY 0.216547827405929 0.31990995910941 0.826118121406705 0.355932203389831 1.1 1 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.31693788846173 0.434389403260697 0.823580124105916 0.354838709677419 1.1 1 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.255887382377757 0.369585826582351 0.822020313264807 0.354166666666667 1.1 1 1 RIBOSOME BIOGENESIS IN EUKARYOTES%KEGG%HSA03008 RIBOSOME BIOGENESIS IN EUKARYOTES 0.212194895777789 0.31990995910941 0.821276403479047 0.353846153846154 1.1 1 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.311853107173518 0.427642560383031 0.819175952319254 0.352941176470588 1.1 1 1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN CELLULAR ROLES OF ANTHRAX TOXIN 0.407149171828194 0.52759330030022 0.819175952319254 0.352941176470588 1.1 1 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.407149171828194 0.52759330030022 0.819175952319254 0.352941176470588 1.1 1 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.407149171828194 0.52759330030022 0.819175952319254 0.352941176470588 1.1 1 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.407149171828194 0.52759330030022 0.819175952319254 0.352941176470588 1.1 1 1 INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION%KEGG%HSA04672 INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 0.306906495679917 0.42107826696563 0.81548597055205 0.351351351351351 1.1 1 1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 BLOOD COAGULATION 0.302096901781264 0.414695226443099 0.812349486049927 0.35 1.1 1 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.396248417245365 0.514986237691487 0.812349486049927 0.35 1.1 1 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.396248417245365 0.514986237691487 0.812349486049927 0.35 1.1 1 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.087993180363922 0.155625765673818 0.811101637377039 0.349462365591398 1.1 1 1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-MEDIATED SIGNALING EVENTS 0.377354472578451 0.491156833262278 0.803422568620806 0.346153846153846 1.1 1 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.353810577195722 0.462879495351277 0.795770925110132 0.342857142857143 1.1 1 1 HEDGEHOG%IOB%HEDGEHOG HEDGEHOG 0.346864542503117 0.462879495351277 0.794025813432259 0.342105263157895 1.1 1 1 HEDGEHOG%NETPATH%HEDGEHOG HEDGEHOG 0.346864542503117 0.462879495351277 0.794025813432259 0.342105263157895 1.1 1 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.240058230449238 0.348971088034532 0.791249499399279 0.340909090909091 1.1 1 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.327994548183388 0.448610800601449 0.790127159683819 0.340425531914894 1.1 1 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 5.97342820813421e-05 0.000328165212184373 0.78800730632857 0.339512195121951 1.1 1 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.291307369928047 0.409258143047554 0.773666177190406 0.333333333333333 1.1 1 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.379343063600351 0.493501558319746 0.773666177190406 0.333333333333333 1.1 1 1 NICOTINATE AND NICOTINAMIDE METABOLISM%KEGG%HSA00760 NICOTINATE AND NICOTINAMIDE METABOLISM 0.453967344581622 0.574154382571577 0.773666177190406 0.333333333333333 1.1 1 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.274490021108788 0.390204951840363 0.773666177190406 0.333333333333333 1.1 1 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.406120030059028 0.527296169013126 0.773666177190406 0.333333333333333 1.1 1 1 ALLOGRAFT REJECTION%KEGG%HSA05330 ALLOGRAFT REJECTION 0.427682626350554 0.549877662450712 0.773666177190406 0.333333333333333 1.1 1 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.427682626350554 0.549877662450712 0.773666177190406 0.333333333333333 1.1 1 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.440087393572384 0.562535364445166 0.773666177190406 0.333333333333333 1.1 1 1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY 0.469799654368874 0.589968840191417 0.773666177190406 0.333333333333333 1.1 1 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.469799654368874 0.589968840191417 0.773666177190406 0.333333333333333 1.1 1 1 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK 0.488345797655711 0.605723362379168 0.773666177190406 0.333333333333333 1.1 1 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.488345797655711 0.605723362379168 0.773666177190406 0.333333333333333 1.1 1 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.488345797655711 0.605723362379168 0.773666177190406 0.333333333333333 1.1 1 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.400701194446264 0.520516773278226 0.757877071533459 0.326530612244898 1.1 1 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.40952227303937 0.53040777701612 0.756847347251484 0.326086956521739 1.1 1 1 BUTANOATE METABOLISM%KEGG%HSA00650 BUTANOATE METABOLISM 0.47766804014653 0.594155953710566 0.746035242290749 0.321428571428571 1.1 1 1 LINOLEIC ACID METABOLISM%KEGG%HSA00591 LINOLEIC ACID METABOLISM 0.493068528611645 0.611006442645163 0.74271953010279 0.32 1.1 1 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.493068528611645 0.611006442645163 0.74271953010279 0.32 1.1 1 1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS VISUAL SIGNAL TRANSDUCTION: RODS 0.510443466946181 0.612901723276138 0.738499532772661 0.318181818181818 1.1 1 1 AMINOACYL-TRNA BIOSYNTHESIS%KEGG%HSA00970 AMINOACYL-TRNA BIOSYNTHESIS 0.470033953625466 0.589968840191417 0.735926363668923 0.317073170731707 1.1 1 1 TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY TRNA CHARGING 0.482427696916624 0.59979341667569 0.732946904706701 0.315789473684211 1.1 1 1 ASCORBATE AND ALDARATE METABOLISM%KEGG%HSA00053 ASCORBATE AND ALDARATE METABOLISM 0.530427255396596 0.634060141650418 0.732946904706701 0.315789473684211 1.1 1 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.530427255396596 0.634060141650418 0.732946904706701 0.315789473684211 1.1 1 1 PRIMARY BILE ACID BIOSYNTHESIS%KEGG%HSA00120 PRIMARY BILE ACID BIOSYNTHESIS 0.554014868308474 0.656306023238744 0.725312041116006 0.3125 1.1 1 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.554014868308474 0.656306023238744 0.725312041116006 0.3125 1.1 1 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.497812730368927 0.612901723276138 0.722088432044379 0.311111111111111 1.1 1 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.423216032177021 0.544931971118557 0.718684824496672 0.309644670050761 1.1 1 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.446471805989138 0.570419647477402 0.716357571472598 0.308641975308642 1.1 1 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.470851232073425 0.589968840191417 0.715821977026638 0.308411214953271 1.1 1 1 GRAFT-VERSUS-HOST DISEASE%KEGG%HSA05332 GRAFT-VERSUS-HOST DISEASE 0.544496997959731 0.645901297174904 0.714153394329606 0.307692307692308 1.1 1 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.544496997959731 0.645901297174904 0.714153394329606 0.307692307692308 1.1 1 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.462661762840054 0.584870119179876 0.712124549459351 0.306818181818182 1.1 1 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.423657946321807 0.545234750829968 0.711852642414884 0.306701030927835 1.1 1 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.522024719402679 0.624582207379703 0.706390857434719 0.304347826086957 1.1 1 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.564716067664297 0.66778308091065 0.706390857434719 0.304347826086957 1.1 1 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.494059242276842 0.611946557953984 0.706390857434719 0.304347826086957 1.1 1 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.486787303042934 0.604643484749985 0.704588839941263 0.303571428571429 1.1 1 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.507472285247257 0.612901723276138 0.703786651508692 0.303225806451613 1.1 1 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.555845455015428 0.657588364681779 0.703332888354915 0.303030303030303 1.1 1 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.555845455015428 0.657588364681779 0.703332888354915 0.303030303030303 1.1 1 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.555845455015428 0.657588364681779 0.703332888354915 0.303030303030303 1.1 1 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.521509762759732 0.624249316567141 0.700678801983764 0.30188679245283 1.1 1 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.521509762759732 0.624249316567141 0.700678801983764 0.30188679245283 1.1 1 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.546830265342509 0.64837743242275 0.700678801983764 0.30188679245283 1.1 1 1 SPHINGOLIPID METABOLISM%KEGG%HSA00600 SPHINGOLIPID METABOLISM 0.56552818307824 0.668443665969215 0.696299559471366 0.3 1.1 1 1 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY 0.587932471747123 0.685401382845784 0.696299559471366 0.3 1.1 1 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.587932471747123 0.685401382845784 0.696299559471366 0.3 1.1 1 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.587932471747123 0.685401382845784 0.696299559471366 0.3 1.1 1 1 RETINOL METABOLISM%KEGG%HSA00830 RETINOL METABOLISM 0.574070707250302 0.678236763001365 0.691361264723342 0.297872340425532 1.1 1 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.58178632364634 0.68042423485558 0.690026590467119 0.297297297297297 1.1 1 1 PANTOTHENATE AND COA BIOSYNTHESIS%KEGG%HSA00770 PANTOTHENATE AND COA BIOSYNTHESIS 0.61520890850859 0.716249841826558 0.682646626932711 0.294117647058824 1.1 1 1 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY 0.61520890850859 0.716249841826558 0.682646626932711 0.294117647058824 1.1 1 1 DRUG METABOLISM - OTHER ENZYMES%KEGG%HSA00983 DRUG METABOLISM - OTHER ENZYMES 0.605043036644904 0.70503689245807 0.679316643386698 0.292682926829268 1.1 1 1 ARACHIDONIC ACID METABOLISM%KEGG%HSA00590 ARACHIDONIC ACID METABOLISM 0.615590088602879 0.716377344945186 0.675199572820718 0.290909090909091 1.1 1 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.618767293896738 0.718585564992807 0.673838283359386 0.290322580645161 1.1 1 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.618767293896738 0.718585564992807 0.673838283359386 0.290322580645161 1.1 1 1 NEUROACTIVE LIGAND-RECEPTOR INTERACTION%KEGG%HSA04080 NEUROACTIVE LIGAND-RECEPTOR INTERACTION 0.713730267678497 0.798856840351527 0.665712757117326 0.286821705426357 1.1 1 1 ASTHMA%KEGG%HSA05310 ASTHMA 0.641518522613324 0.741966817601463 0.663142437591777 0.285714285714286 1.1 1 1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY 0.641518522613324 0.741966817601463 0.663142437591777 0.285714285714286 1.1 1 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.641518522613324 0.741966817601463 0.663142437591777 0.285714285714286 1.1 1 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.640887179268742 0.741966817601463 0.663142437591777 0.285714285714286 1.1 1 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.722149938699927 0.807937797349049 0.653802403259498 0.28169014084507 1.1 1 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.694138806091372 0.778250013462138 0.64683565633952 0.278688524590164 1.1 1 1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY 0.671135544716173 0.756759964253215 0.644721814325338 0.277777777777778 1.1 1 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.671135544716173 0.756759964253215 0.644721814325338 0.277777777777778 1.1 1 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.782212933295681 0.859456460458629 0.640766465771195 0.276073619631902 1.1 1 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.75562056882181 0.837333596077778 0.630394662895887 0.271604938271605 1.1 1 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.726128994262497 0.811700787566852 0.628603768967205 0.270833333333333 1.1 1 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.878603644013286 0.945278583950647 0.62035905452134 0.267281105990783 1.1 1 1 AUTOIMMUNE THYROID DISEASE%KEGG%HSA05320 AUTOIMMUNE THYROID DISEASE 0.723165688040207 0.808731093877026 0.618932941752325 0.266666666666667 1.1 1 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.846572208168071 0.916048794804762 0.61438196423944 0.264705882352941 1.1 1 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.858992563104735 0.926826263873644 0.609897424354481 0.262773722627737 1.1 1 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.735126586426458 0.821410512036682 0.605477877801187 0.260869565217391 1.1 1 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.759478172959675 0.837333596077778 0.598967362986121 0.258064516129032 1.1 1 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.897679631453122 0.960316912025105 0.592955829233523 0.255474452554745 1.1 1 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.842582115675684 0.912105516845968 0.588422162933548 0.253521126760563 1.1 1 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.774824196236523 0.85169295768058 0.580249632892805 0.25 1.1 1 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.923256836954066 0.986478233001569 0.580249632892805 0.25 1.1 1 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.932419723640196 0.99546186689846 0.558758905748627 0.240740740740741 1.1 1 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.851755384010028 0.920151153870412 0.549710178530025 0.236842105263158 1.1 1 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.847584017833637 0.916767454892248 0.546117301546169 0.235294117647059 1.1 1 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.938509518568787 1 0.541566324033284 0.233333333333333 1.1 1 1 PROTEIN EXPORT%KEGG%HSA03060 PROTEIN EXPORT 0.866937425816373 0.934633684332696 0.504564898167656 0.217391304347826 1.1 1 1 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY 0.866937425816373 0.934633684332696 0.504564898167656 0.217391304347826 1.1 1 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999997514 1 0.496939232200387 0.214105793450882 1.1 1 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.944999718006551 1 0.483541360744004 0.208333333333333 1.1 1 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.925324721051481 0.988287278012457 0.464199706314244 0.2 1.1 1 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.939008159979998 1 0.449225522239591 0.193548387096774 1.1 1 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.991116427726639 1 0.440695923716054 0.189873417721519 1.1 1 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.440695923716054 0.189873417721519 1.1 1 1 STEROID HORMONE BIOSYNTHESIS%KEGG%HSA00140 STEROID HORMONE BIOSYNTHESIS 0.975439616190068 1 0.421999733012949 0.181818181818182 1.1 1 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.953838694360448 1 0.414464023494861 0.178571428571429 1.1 1 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.98679374588094 1 0.39506357984191 0.170212765957447 1.1 1 1 OLFACTORY TRANSDUCTION%KEGG%HSA04740 OLFACTORY TRANSDUCTION 1 1 0.185357521618535 0.0798611111111111 1.1 1 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0973321964852447 0.0419354838709677 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 4.31097025682169e-05 0.000601482992975598 5.99701670644391 0.75 1.3 1 3 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY 4.58179586586031e-05 0.000621503925151188 5.08837781152817 0.636363636363636 1.3 1 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 4.58179586586031e-05 0.000621503925151188 5.08837781152817 0.636363636363636 1.3 1 3 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-CADHERIN SIGNALING IN KERATINOCYTES 8.3081547326176e-08 3.04286167082119e-06 5.05011933174224 0.631578947368421 1.3 1 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.000709255020706258 0.00561653300180902 4.9975139220366 0.625 1.3 1 3 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY 3.73853154850555e-05 0.000530308753949369 4.56915558586203 0.571428571428571 1.3 1 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 3.73853154850555e-05 0.000530308753949369 4.56915558586203 0.571428571428571 1.3 1 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 7.22770464313085e-05 0.000882382275182224 4.26454521347123 0.533333333333333 1.3 1 3 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY 2.70243938906095e-05 0.000411926743870158 4.23318826337217 0.529411764705882 1.3 1 3 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY 2.70243938906095e-05 0.000411926743870158 4.23318826337217 0.529411764705882 1.3 1 3 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 FORWARD SIGNALING 1.01563768465243e-05 0.000192399000068774 4.20843277645187 0.526315789473684 1.3 1 3 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY 1.4515306620106e-06 3.64541557687804e-05 4.17183770883055 0.521739130434783 1.3 1 3 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 PATHWAY 2.0989370591323e-07 7.18817795445697e-06 4.14608562420814 0.518518518518518 1.3 1 3 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE 1.25257423065178e-13 3.30303824622874e-11 4.06815168390347 0.508771929824561 1.3 1 3 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES 6.89317208092235e-06 0.000141701975726758 3.99801113762928 0.5 1.3 1 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 6.89317208092235e-06 0.000141701975726758 3.99801113762928 0.5 1.3 1 3 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY 1.82827326853535e-05 0.000299450721063833 3.99801113762928 0.5 1.3 1 3 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY 4.87030757910247e-05 0.000635792132974911 3.99801113762928 0.5 1.3 1 3 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY 0.000130438934929148 0.00141550399756446 3.99801113762928 0.5 1.3 1 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000956811949869186 0.00712017308979199 3.99801113762928 0.5 1.3 1 3 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY 0.00263392253406075 0.0146532778951861 3.99801113762928 0.5 1.3 1 3 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF AND VEGFR SIGNALING NETWORK 0.00263392253406075 0.0146532778951861 3.99801113762928 0.5 1.3 1 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.00263392253406075 0.0146532778951861 3.99801113762928 0.5 1.3 1 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.00263392253406075 0.0146532778951861 3.99801113762928 0.5 1.3 1 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00263392253406075 0.0146532778951861 3.99801113762928 0.5 1.3 1 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00263392253406075 0.0146532778951861 3.99801113762928 0.5 1.3 1 3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY 3.76676906901683e-07 1.17565280941059e-05 3.99801113762928 0.5 1.3 1 3 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING 0.00035172606904176 0.00310201218750208 3.99801113762928 0.5 1.3 1 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00035172606904176 0.00310201218750208 3.99801113762928 0.5 1.3 1 3 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY 1.40402678861299e-08 7.80255402007998e-07 3.88995678255821 0.486486486486487 1.3 1 3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 1.18813433815915e-05 0.000213136751682019 3.824184566428 0.478260869565217 1.3 1 3 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY 1.18813433815915e-05 0.000213136751682019 3.824184566428 0.478260869565217 1.3 1 3 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY 1.18813433815915e-05 0.000213136751682019 3.824184566428 0.478260869565217 1.3 1 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 8.33951048410747e-05 0.000979468052061687 3.78758949880668 0.473684210526316 1.3 1 3 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY 0.00022236297140785 0.00218782883720249 3.76283401188638 0.470588235294118 1.3 1 3 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY 0.00022236297140785 0.00218782883720249 3.76283401188638 0.470588235294118 1.3 1 3 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY 0.00022236297140785 0.00218782883720249 3.76283401188638 0.470588235294118 1.3 1 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00022236297140785 0.00218782883720249 3.76283401188638 0.470588235294118 1.3 1 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00022236297140785 0.00218782883720249 3.76283401188638 0.470588235294118 1.3 1 3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS NETRIN-MEDIATED SIGNALING EVENTS 1.09962288310735e-06 2.8997055427541e-05 3.73147706178732 0.466666666666667 1.3 1 3 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY 0.000596243963825903 0.00482618999808316 3.73147706178732 0.466666666666667 1.3 1 3 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY 0.000596243963825903 0.00482618999808316 3.73147706178732 0.466666666666667 1.3 1 3 TNFSF3%IOB%TNFSF3 TNFSF3 0.00161017445638842 0.0106952897770687 3.6904718193501 0.461538461538462 1.3 1 3 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY 0.00161017445638842 0.0106952897770687 3.6904718193501 0.461538461538462 1.3 1 3 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY ATYPICAL NF-KAPPAB PATHWAY 0.00161017445638842 0.0106952897770687 3.6904718193501 0.461538461538462 1.3 1 3 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING 1.46517961581455e-09 1.07324406858416e-07 3.66484354282684 0.458333333333333 1.3 1 3 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY 5.18570070809982e-05 0.000654291519964556 3.63455557966298 0.454545454545455 1.3 1 3 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY 5.18570070809982e-05 0.000654291519964556 3.63455557966298 0.454545454545455 1.3 1 3 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY 5.18570070809982e-05 0.000654291519964556 3.63455557966298 0.454545454545455 1.3 1 3 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY 0.00438878675177137 0.021352824104098 3.63455557966298 0.454545454545455 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00438878675177137 0.021352824104098 3.63455557966298 0.454545454545455 1.3 1 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00438878675177137 0.021352824104098 3.63455557966298 0.454545454545455 1.3 1 3 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY 1.79963538511051e-06 4.31421682776039e-05 3.61110683398773 0.451612903225806 1.3 1 3 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY 4.31064033996849e-07 1.26301761961077e-05 3.55378767789269 0.444444444444444 1.3 1 3 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY 0.00036129088790131 0.00316519625048424 3.55378767789269 0.444444444444444 1.3 1 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00036129088790131 0.00316519625048424 3.55378767789269 0.444444444444444 1.3 1 3 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY 0.000958536764078936 0.00712017308979199 3.49825974542562 0.4375 1.3 1 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000958536764078936 0.00712017308979199 3.49825974542562 0.4375 1.3 1 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000958536764078936 0.00712017308979199 3.49825974542562 0.4375 1.3 1 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.34905238824618e-09 1.63011872310663e-07 3.46997193077258 0.433962264150943 1.3 1 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000215606336588668 0.00217005309001648 3.42686668939652 0.428571428571429 1.3 1 3 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN 1.74652574460757e-06 4.22531044819282e-05 3.42686668939652 0.428571428571429 1.3 1 3 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY NECTIN ADHESION PATHWAY 1.91386146614067e-05 0.000309622864184843 3.42686668939652 0.428571428571429 1.3 1 3 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-MEDIATED SIGNALING EVENTS 0.00255401074689843 0.0144216838106449 3.42686668939652 0.428571428571429 1.3 1 3 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY CIRCADIAN RHYTHM PATHWAY 0.00255401074689843 0.0144216838106449 3.42686668939652 0.428571428571429 1.3 1 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00255401074689843 0.0144216838106449 3.42686668939652 0.428571428571429 1.3 1 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00255401074689843 0.0144216838106449 3.42686668939652 0.428571428571429 1.3 1 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00255401074689843 0.0144216838106449 3.42686668939652 0.428571428571429 1.3 1 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.06549766849428e-12 1.41791449012129e-09 3.39557110319199 0.424657534246575 1.3 1 3 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 SIGNALING EVENTS 8.41523124309964e-11 1.10954823940269e-08 3.39225187435211 0.424242424242424 1.3 1 3 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 SIGNALING EVENTS 4.9407841663115e-05 0.000638669012086443 3.38293250107093 0.423076923076923 1.3 1 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.9407841663115e-05 0.000638669012086443 3.38293250107093 0.423076923076923 1.3 1 3 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY 0.000563396911945118 0.00462827930467064 3.3667462211615 0.421052631578947 1.3 1 3 NOTCH%IOB%NOTCH NOTCH 1.24030894479855e-11 2.04418417964611e-09 3.34968500720291 0.418918918918919 1.3 1 3 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY 0.000127521635017892 0.00138956426257099 3.3316759480244 0.416666666666667 1.3 1 3 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-MEDIATED SIGNALING EVENTS 0.000127521635017892 0.00138956426257099 3.3316759480244 0.416666666666667 1.3 1 3 IL9%NETPATH%IL9 IL9 0.000127521635017892 0.00138956426257099 3.3316759480244 0.416666666666667 1.3 1 3 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00684019732455864 0.0306241092442464 3.3316759480244 0.416666666666667 1.3 1 3 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 SIGNALING PATHWAY 1.4202601174207e-08 7.80255402007998e-07 3.31910358595638 0.415094339622642 1.3 1 3 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY 2.93466109639222e-05 0.000441158100672427 3.30869887252078 0.413793103448276 1.3 1 3 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING NONGENOTROPIC ANDROGEN SIGNALING 2.93466109639222e-05 0.000441158100672427 3.30869887252078 0.413793103448276 1.3 1 3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RHOA SIGNALING PATHWAY 3.78955209707624e-07 1.17565280941059e-05 3.27110002169668 0.409090909090909 1.3 1 3 CIRCADIAN RHYTHM - MAMMAL%KEGG%HSA04710 CIRCADIAN RHYTHM - MAMMAL 0.000328971257017055 0.00298109005070094 3.27110002169668 0.409090909090909 1.3 1 3 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY 0.000328971257017055 0.00298109005070094 3.27110002169668 0.409090909090909 1.3 1 3 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL SIGNALING EVENTS MEDIATED BY PRL 0.000328971257017055 0.00298109005070094 3.27110002169668 0.409090909090909 1.3 1 3 LEPTIN%IOB%LEPTIN LEPTIN 8.99813233463823e-08 3.25042122827959e-06 3.26368256133002 0.408163265306122 1.3 1 3 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE 4.05327818598654e-06 8.76106112823484e-05 3.24163065213185 0.405405405405405 1.3 1 3 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING INTEGRIN-LINKED KINASE SIGNALING 9.54135692809258e-07 2.64847981256633e-05 3.23648520665227 0.404761904761905 1.3 1 3 SHIGELLOSIS%KEGG%HSA05131 SHIGELLOSIS 1.28236216432903e-08 7.35128049420794e-07 3.2264651286131 0.403508771929825 1.3 1 3 NOTCH%NETPATH%NOTCH NOTCH 1.77103833715147e-10 1.86809123802737e-08 3.22062008309025 0.402777777777778 1.3 1 3 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY 0.0038591886022801 0.0196841012460593 3.19840891010342 0.4 1.3 1 3 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY 0.0038591886022801 0.0196841012460593 3.19840891010342 0.4 1.3 1 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0038591886022801 0.0196841012460593 3.19840891010342 0.4 1.3 1 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0038591886022801 0.0196841012460593 3.19840891010342 0.4 1.3 1 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0038591886022801 0.0196841012460593 3.19840891010342 0.4 1.3 1 3 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY 1.02220727066378e-05 0.000192399000068774 3.19840891010342 0.4 1.3 1 3 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY 0.000191411503302734 0.00194614771356723 3.19840891010342 0.4 1.3 1 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000847882277323478 0.00642490104971843 3.19840891010342 0.4 1.3 1 3 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-MEDIATED SIGNALING EVENTS 2.57153714918952e-05 0.000398890791906633 3.14994816904125 0.393939393939394 1.3 1 3 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS 2.57153714918952e-05 0.000398890791906633 3.14994816904125 0.393939393939394 1.3 1 3 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE 0.00011116261537153 0.00124210091836747 3.14129446528015 0.392857142857143 1.3 1 3 IL-7%NETPATH%IL-7 IL-7 0.00011116261537153 0.00124210091836747 3.14129446528015 0.392857142857143 1.3 1 3 FSH%NETPATH%FSH FSH 8.33204372853094e-07 2.33740418214214e-05 3.12887828162291 0.391304347826087 1.3 1 3 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC PATHWAY 0.000487347946630089 0.00406688776982134 3.12887828162291 0.391304347826087 1.3 1 3 GDNF%IOB%GDNF GDNF 1.50176654503795e-05 0.000260536735477965 3.1095642181561 0.388888888888889 1.3 1 3 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY 0.00218185593870613 0.0128714857055214 3.1095642181561 0.388888888888889 1.3 1 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00218185593870613 0.0128714857055214 3.1095642181561 0.388888888888889 1.3 1 3 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY 2.06665911808733e-06 4.86587508428241e-05 3.08937224271353 0.386363636363636 1.3 1 3 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY 0.000280163791827495 0.00261057215211698 3.07539318279175 0.384615384615385 1.3 1 3 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY 0.000280163791827495 0.00261057215211698 3.07539318279175 0.384615384615385 1.3 1 3 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 SPECIFIC SIGNALS 0.000280163791827495 0.00261057215211698 3.07539318279175 0.384615384615385 1.3 1 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000280163791827495 0.00261057215211698 3.07539318279175 0.384615384615385 1.3 1 3 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY 0.010108961617165 0.0417826516997871 3.07539318279175 0.384615384615385 1.3 1 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.010108961617165 0.0417826516997871 3.07539318279175 0.384615384615385 1.3 1 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.010108961617165 0.0417826516997871 3.07539318279175 0.384615384615385 1.3 1 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.010108961617165 0.0417826516997871 3.07539318279175 0.384615384615385 1.3 1 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.010108961617165 0.0417826516997871 3.07539318279175 0.384615384615385 1.3 1 3 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY REGULATION OF RAC1 ACTIVITY 3.74051680828907e-05 0.000530308753949369 3.05730263465768 0.382352941176471 1.3 1 3 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY 0.00123697516392952 0.00862937435788924 3.04610372390802 0.380952380952381 1.3 1 3 BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY 0.00123697516392952 0.00862937435788924 3.04610372390802 0.380952380952381 1.3 1 3 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY 0.00123697516392952 0.00862937435788924 3.04610372390802 0.380952380952381 1.3 1 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00123697516392952 0.00862937435788924 3.04610372390802 0.380952380952381 1.3 1 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00123697516392952 0.00862937435788924 3.04610372390802 0.380952380952381 1.3 1 3 ADHERENS JUNCTION%KEGG%HSA04520 ADHERENS JUNCTION 3.37030435209137e-09 2.11606966106308e-07 3.04074086523917 0.380281690140845 1.3 1 3 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS OSTEOPONTIN-MEDIATED EVENTS 0.000161161284731735 0.00168714508688148 3.03297396647738 0.379310344827586 1.3 1 3 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES 2.97779933465569e-06 6.71150157733937e-05 3.02071952620879 0.377777777777778 1.3 1 3 IFN-GAMMA%IOB%IFN-GAMMA IFN-GAMMA 1.25806214330916e-05 0.00022116732479375 2.99850835322196 0.375 1.3 1 3 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY 1.25806214330916e-05 0.00022116732479375 2.99850835322196 0.375 1.3 1 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.25806214330916e-05 0.00022116732479375 2.99850835322196 0.375 1.3 1 3 TNFSF1%IOB%TNFSF1 TNFSF1 0.0055995797052008 0.0261346755444505 2.99850835322196 0.375 1.3 1 3 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY 0.0055995797052008 0.0261346755444505 2.99850835322196 0.375 1.3 1 3 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY 0.0055995797052008 0.0261346755444505 2.99850835322196 0.375 1.3 1 3 BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY 0.0055995797052008 0.0261346755444505 2.99850835322196 0.375 1.3 1 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0055995797052008 0.0261346755444505 2.99850835322196 0.375 1.3 1 3 BACTERIAL INVASION OF EPITHELIAL CELLS%KEGG%HSA05100 BACTERIAL INVASION OF EPITHELIAL CELLS 1.99572372667544e-08 1.07402519739656e-06 2.98359040121588 0.373134328358209 1.3 1 3 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY REGULATION OF RHOA ACTIVITY 7.29813263851707e-06 0.000146909738685263 2.97526410242179 0.372093023255814 1.3 1 3 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-MEDIATED SIGNALING EVENTS 9.73298519705217e-10 8.0205881139458e-08 2.96148973157724 0.37037037037037 1.3 1 3 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING 3.4328416173572e-07 1.09065100541818e-05 2.94590294351631 0.368421052631579 1.3 1 3 GLYCOSAMINOGLYCAN DEGRADATION%KEGG%HSA00531 GLYCOSAMINOGLYCAN DEGRADATION 0.00312595703765005 0.016926383384565 2.94590294351631 0.368421052631579 1.3 1 3 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY 0.00312595703765005 0.016926383384565 2.94590294351631 0.368421052631579 1.3 1 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00312595703765005 0.016926383384565 2.94590294351631 0.368421052631579 1.3 1 3 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY 0.000229009495745506 0.00222840605269704 2.93187483426147 0.366666666666667 1.3 1 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000229009495745506 0.00222840605269704 2.93187483426147 0.366666666666667 1.3 1 3 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-MEDIATED SIGNALING EVENTS 1.42748846973879e-06 3.61950682182806e-05 2.92162352365216 0.365384615384615 1.3 1 3 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF SIGNALING PATHWAY 1.42748846973879e-06 3.61950682182806e-05 2.92162352365216 0.365384615384615 1.3 1 3 NOTCH SIGNALING PATHWAY%KEGG%HSA04330 NOTCH SIGNALING PATHWAY 1.02875460787627e-05 0.000192399000068774 2.90764446373038 0.363636363636364 1.3 1 3 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY 0.00175583453930806 0.0114042750742743 2.90764446373038 0.363636363636364 1.3 1 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00175583453930806 0.0114042750742743 2.90764446373038 0.363636363636364 1.3 1 3 IL3%NETPATH%IL3 IL3 3.28762849886763e-09 2.11450642719853e-07 2.89855807478123 0.3625 1.3 1 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.60681659725383e-06 2.89710952002121 0.36231884057971 1.3 1 3 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ERBB1 DOWNSTREAM SIGNALING 9.39998997840508e-11 1.12671698059337e-08 2.88516267663968 0.360824742268041 1.3 1 3 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY 0.000991149363138164 0.0072803923972015 2.87856801909308 0.36 1.3 1 3 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY P38 MAPK SIGNALING PATHWAY 0.000991149363138164 0.0072803923972015 2.87856801909308 0.36 1.3 1 3 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM 0.000991149363138164 0.0072803923972015 2.87856801909308 0.36 1.3 1 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.48573920531026e-05 0.000390172278833521 2.85572224116377 0.357142857142857 1.3 1 3 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY 0.000561775456805591 0.00462827930467064 2.85572224116377 0.357142857142857 1.3 1 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000561775456805591 0.00462827930467064 2.85572224116377 0.357142857142857 1.3 1 3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7228 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0143061565450909 0.0538012082267256 2.85572224116377 0.357142857142857 1.3 1 3 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY 0.0143061565450909 0.0538012082267256 2.85572224116377 0.357142857142857 1.3 1 3 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY 0.0143061565450909 0.0538012082267256 2.85572224116377 0.357142857142857 1.3 1 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0143061565450909 0.0538012082267256 2.85572224116377 0.357142857142857 1.3 1 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0143061565450909 0.0538012082267256 2.85572224116377 0.357142857142857 1.3 1 3 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY 0.000319491793085255 0.00292534673043687 2.83729822670465 0.354838709677419 1.3 1 3 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO SIGNALING PATHWAY 0.000319491793085255 0.00292534673043687 2.83729822670465 0.354838709677419 1.3 1 3 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF RECEPTOR (ERBB1) SIGNALING PATHWAY 0.000319491793085255 0.00292534673043687 2.83729822670465 0.354838709677419 1.3 1 3 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 0.000182221927011954 0.00186247760283149 2.82212550891478 0.352941176470588 1.3 1 3 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 NOTCH SIGNALING PATHWAY 0.000182221927011954 0.00186247760283149 2.82212550891478 0.352941176470588 1.3 1 3 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY 0.00784997313406559 0.033768970888305 2.82212550891478 0.352941176470588 1.3 1 3 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY 0.00784997313406559 0.033768970888305 2.82212550891478 0.352941176470588 1.3 1 3 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY 0.00784997313406559 0.033768970888305 2.82212550891478 0.352941176470588 1.3 1 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00784997313406559 0.033768970888305 2.82212550891478 0.352941176470588 1.3 1 3 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP SIGNALING EVENTS MEDIATED BY TCPTP 0.000104184698559048 0.00118420280215608 2.8094132318476 0.351351351351351 1.3 1 3 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB FORWARD SIGNALING 0.000104184698559048 0.00118420280215608 2.8094132318476 0.351351351351351 1.3 1 3 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) 2.5718261076984e-08 1.32978538156876e-06 2.80380001859715 0.350649350649351 1.3 1 3 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION 5.96930057212472e-05 0.000742502151353438 2.79860779634049 0.35 1.3 1 3 BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-ALPHA SIGNALING PATHWAY 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES P38 SIGNALING MEDIATED BY MAPKAP KINASES 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0043526126778259 0.021352824104098 2.79860779634049 0.35 1.3 1 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.96994613239558e-05 0.000316752923849217 2.78122513922037 0.347826086956522 1.3 1 3 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 0.00243236072206965 0.0139741508150276 2.78122513922037 0.347826086956522 1.3 1 3 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY 0.00243236072206965 0.0139741508150276 2.78122513922037 0.347826086956522 1.3 1 3 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY 0.00243236072206965 0.0139741508150276 2.78122513922037 0.347826086956522 1.3 1 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00243236072206965 0.0139741508150276 2.78122513922037 0.347826086956522 1.3 1 3 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-BETA SIGNALING PATHWAY 5.70021644297846e-12 1.07367648286673e-09 2.77547880628809 0.347107438016529 1.3 1 3 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING EPHRIN B REVERSE SIGNALING 0.00136755348912616 0.00934258691923753 2.76785386451258 0.346153846153846 1.3 1 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00136755348912616 0.00934258691923753 2.76785386451258 0.346153846153846 1.3 1 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00136755348912616 0.00934258691923753 2.76785386451258 0.346153846153846 1.3 1 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00136755348912616 0.00934258691923753 2.76785386451258 0.346153846153846 1.3 1 3 GM-CSF%IOB%GM-CSF GM-CSF 3.51777120327324e-08 1.60681659725383e-06 2.76785386451258 0.346153846153846 1.3 1 3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0.000772625021054989 0.00599238876624119 2.75724906043398 0.344827586206897 1.3 1 3 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY 0.000772625021054989 0.00599238876624119 2.75724906043398 0.344827586206897 1.3 1 3 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA REGULATION OF P38-ALPHA AND P38-BETA 0.000772625021054989 0.00599238876624119 2.75724906043398 0.344827586206897 1.3 1 3 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.000772625021054989 0.00599238876624119 2.75724906043398 0.344827586206897 1.3 1 3 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA RECEPTOR MEDIATED EVENTS 1.26040751993423e-06 3.29078676244214e-05 2.75272898000704 0.344262295081967 1.3 1 3 SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP 0.00043824309450288 0.00372506503166976 2.74863265712013 0.34375 1.3 1 3 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L SIGNALING 0.000249397937839183 0.00239149949847973 2.74149335151722 0.342857142857143 1.3 1 3 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS ARF6 SIGNALING EVENTS 0.000249397937839183 0.00239149949847973 2.74149335151722 0.342857142857143 1.3 1 3 IL2%NETPATH%IL2 IL2 4.77973004332795e-08 1.88121613794863e-06 2.73281773964533 0.341772151898734 1.3 1 3 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION 4.66658237314885e-05 0.000621503925151188 2.72591668474723 0.340909090909091 1.3 1 3 CXCR4%IOB%CXCR4 CXCR4 5.44908612065759e-09 3.26573638640319e-07 2.72391967618698 0.340659340659341 1.3 1 3 PATHOGENIC ESCHERICHIA COLI INFECTION%KEGG%HSA05130 PATHOGENIC ESCHERICHIA COLI INFECTION 2.67964518642698e-05 0.000411926743870158 2.72205013625823 0.340425531914894 1.3 1 3 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING THROMBOXANE A2 RECEPTOR SIGNALING 8.87539859460183e-06 0.000172740384818579 2.71563020669158 0.339622641509434 1.3 1 3 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B SIGNALING EVENTS MEDIATED BY PTP1B 8.87539859460183e-06 0.000172740384818579 2.71563020669158 0.339622641509434 1.3 1 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.11767598591776e-06 0.000109717980283456 2.71293612910558 0.339285714285714 1.3 1 3 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 9.87131517875588e-07 2.67400950226284e-05 2.70634600085674 0.338461538461538 1.3 1 3 LEPTIN%NETPATH%LEPTIN LEPTIN 4.27107066149331e-09 2.61925891496694e-07 2.6933969769292 0.336842105263158 1.3 1 3 TSLP%NETPATH%TSLP TSLP 1.99123078371818e-13 4.77352325151349e-11 2.66534075841952 0.333333333333333 1.3 1 3 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY 5.02451879784633e-08 1.94847883381188e-06 2.66534075841952 0.333333333333333 1.3 1 3 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-BETA RECEPTOR SIGNALING 3.60647707140808e-05 0.00051968743373241 2.66534075841952 0.333333333333333 1.3 1 3 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY 0.000336496581226238 0.00299777528612699 2.66534075841952 0.333333333333333 1.3 1 3 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR 0.000336496581226238 0.00299777528612699 2.66534075841952 0.333333333333333 1.3 1 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000336496581226238 0.00299777528612699 2.66534075841952 0.333333333333333 1.3 1 3 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING AURORA A SIGNALING 0.00104443278370973 0.00752505259738404 2.66534075841952 0.333333333333333 1.3 1 3 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY 0.00104443278370973 0.00752505259738404 2.66534075841952 0.333333333333333 1.3 1 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00104443278370973 0.00752505259738404 2.66534075841952 0.333333333333333 1.3 1 3 THYROID CANCER%KEGG%HSA05216 THYROID CANCER 0.00185090908411396 0.0118467166378848 2.66534075841952 0.333333333333333 1.3 1 3 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS 0.00329691921630579 0.0175635878250472 2.66534075841952 0.333333333333333 1.3 1 3 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 PATHWAY 0.00329691921630579 0.0175635878250472 2.66534075841952 0.333333333333333 1.3 1 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00329691921630579 0.0175635878250472 2.66534075841952 0.333333333333333 1.3 1 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00329691921630579 0.0175635878250472 2.66534075841952 0.333333333333333 1.3 1 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00329691921630579 0.0175635878250472 2.66534075841952 0.333333333333333 1.3 1 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00329691921630579 0.0175635878250472 2.66534075841952 0.333333333333333 1.3 1 3 DORSO-VENTRAL AXIS FORMATION%KEGG%HSA04320 DORSO-VENTRAL AXIS FORMATION 0.00591043143477409 0.0272003624668399 2.66534075841952 0.333333333333333 1.3 1 3 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY 0.00591043143477409 0.0272003624668399 2.66534075841952 0.333333333333333 1.3 1 3 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM 0.0106840317317454 0.0432113369273198 2.66534075841952 0.333333333333333 1.3 1 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0106840317317454 0.0432113369273198 2.66534075841952 0.333333333333333 1.3 1 3 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%HUMANCYC%PWY-7200 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY ARF6 DOWNSTREAM PATHWAY 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0195296405164963 0.0685851932967931 2.66534075841952 0.333333333333333 1.3 1 3 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I SIGNALING EVENTS MEDIATED BY HDAC CLASS I 2.29305601763258e-06 5.30420063026063e-05 2.66534075841952 0.333333333333333 1.3 1 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.29305601763258e-06 5.30420063026063e-05 2.66534075841952 0.333333333333333 1.3 1 3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ERBB2 ERBB3 SIGNALING EVENTS 0.000191884112828017 0.00194614771356723 2.66534075841952 0.333333333333333 1.3 1 3 IL6%NETPATH%IL6 IL6 1.15440950555201e-07 4.05890382152088e-06 2.63283660282904 0.329268292682927 1.3 1 3 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY REGULATION OF ANDROGEN RECEPTOR ACTIVITY 4.80516332641356e-05 0.000630408740883212 2.61094604906402 0.326530612244898 1.3 1 3 G-CSF%IOB%G-CSF G-CSF 0.000146103773135998 0.00155617965550568 2.60335608961906 0.325581395348837 1.3 1 3 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY 4.54716053761289e-07 1.3033546019223e-05 2.5961111283307 0.324675324675325 1.3 1 3 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY 0.000448006284906486 0.00376239673024969 2.59330452170548 0.324324324324324 1.3 1 3 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION 0.000787699322473326 0.00603826486442489 2.58694838317188 0.323529411764706 1.3 1 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000787699322473326 0.00603826486442489 2.58694838317188 0.323529411764706 1.3 1 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000787699322473326 0.00603826486442489 2.58694838317188 0.323529411764706 1.3 1 3 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY 0.0013896427792452 0.0094689612632289 2.57936202427695 0.32258064516129 1.3 1 3 ANGIOGENESIS%PANTHER PATHWAY%P00005 ANGIOGENESIS 2.06967159063466e-11 3.03206888027978e-09 2.57015001704739 0.321428571428571 1.3 1 3 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY 0.00246155132862844 0.0140805007670135 2.57015001704739 0.321428571428571 1.3 1 3 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY REGULATION OF CDC42 ACTIVITY 0.00246155132862844 0.0140805007670135 2.57015001704739 0.321428571428571 1.3 1 3 CD40%IOB%CD40 CD40 0.0043819873825023 0.021352824104098 2.55872712808274 0.32 1.3 1 3 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY 0.0043819873825023 0.021352824104098 2.55872712808274 0.32 1.3 1 3 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR 0.0043819873825023 0.021352824104098 2.55872712808274 0.32 1.3 1 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0043819873825023 0.021352824104098 2.55872712808274 0.32 1.3 1 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.0043819873825023 0.021352824104098 2.55872712808274 0.32 1.3 1 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0043819873825023 0.021352824104098 2.55872712808274 0.32 1.3 1 3 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 TRANSCRIPTION FACTOR NETWORK 3.07537742948106e-06 6.87268667927251e-05 2.54945637761867 0.318840579710145 1.3 1 3 ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY 0.00784924331932488 0.033768970888305 2.54418890576408 0.318181818181818 1.3 1 3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 ENDOGENOUS_CANNABINOID_SIGNALING 0.00784924331932488 0.033768970888305 2.54418890576408 0.318181818181818 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000336372479941795 0.00299777528612699 2.53532413605759 0.317073170731707 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000336372479941795 0.00299777528612699 2.53532413605759 0.317073170731707 1.3 1 3 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS ENDOTHELINS 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.58982224636117e-05 0.000262022578978401 2.53207372049854 0.316666666666667 1.3 1 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000589090432266955 0.00480938535569028 2.52505966587112 0.315789473684211 1.3 1 3 TNFSF8%IOB%TNFSF8 TNFSF8 0.0141723738982509 0.053773453193795 2.52505966587112 0.315789473684211 1.3 1 3 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 PATHWAY 0.0141723738982509 0.053773453193795 2.52505966587112 0.315789473684211 1.3 1 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0141723738982509 0.053773453193795 2.52505966587112 0.315789473684211 1.3 1 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0141723738982509 0.053773453193795 2.52505966587112 0.315789473684211 1.3 1 3 LEUKOCYTE TRANSENDOTHELIAL MIGRATION%KEGG%HSA04670 LEUKOCYTE TRANSENDOTHELIAL MIGRATION 1.01884327891042e-08 5.97042161441503e-07 2.51726627184066 0.314814814814815 1.3 1 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00103442079043064 0.00751451136188869 2.51303557222412 0.314285714285714 1.3 1 3 IL1%NETPATH%IL1 IL1 6.93195103100184e-06 0.000141701975726758 2.50621593702134 0.313432835820896 1.3 1 3 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 1.274653339617e-15 4.80180122367149e-13 2.50342753477721 0.313084112149533 1.3 1 3 IL4%NETPATH%IL4 IL4 1.02036771447989e-06 2.71788854856917e-05 2.4987569610183 0.3125 1.3 1 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000144176313777357 0.00154549975378411 2.4987569610183 0.3125 1.3 1 3 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-CADHERIN SIGNALING EVENTS 0.0018220971814008 0.0117302539251419 2.4987569610183 0.3125 1.3 1 3 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II SIGNALING EVENTS MEDIATED BY HDAC CLASS II 0.0018220971814008 0.0117302539251419 2.4987569610183 0.3125 1.3 1 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.0018220971814008 0.0117302539251419 2.4987569610183 0.3125 1.3 1 3 RENIN-ANGIOTENSIN SYSTEM%KEGG%HSA04614 RENIN-ANGIOTENSIN SYSTEM 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0258614863398124 0.0855120755761647 2.4987569610183 0.3125 1.3 1 3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 1.22508388734930e-13 3.30303824622874e-11 2.49338329013439 0.311827956989247 1.3 1 3 M-CSF%IOB%M-CSF M-CSF 3.5806868375333e-05 0.00051880610937227 2.48152415439059 0.310344827586207 1.3 1 3 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-MEDIATED THROMBIN SIGNALING EVENTS 0.000437988374623916 0.00372506503166976 2.47495927567527 0.30952380952381 1.3 1 3 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING 0.000437988374623916 0.00372506503166976 2.47495927567527 0.30952380952381 1.3 1 3 COLLECTING DUCT ACID SECRETION%KEGG%HSA04966 COLLECTING DUCT ACID SECRETION 0.00572173577955835 0.0265170777692362 2.4603145462334 0.307692307692308 1.3 1 3 BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY 0.00572173577955835 0.0265170777692362 2.4603145462334 0.307692307692308 1.3 1 3 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY 0.00572173577955835 0.0265170777692362 2.4603145462334 0.307692307692308 1.3 1 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00572173577955835 0.0265170777692362 2.4603145462334 0.307692307692308 1.3 1 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.90554636331709e-07 2.67400950226284e-05 2.44584210772615 0.305882352941176 1.3 1 3 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY 0.00134150744248058 0.00928492159008214 2.44322902855122 0.305555555555556 1.3 1 3 BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY 0.00134150744248058 0.00928492159008214 2.44322902855122 0.305555555555556 1.3 1 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00134150744248058 0.00928492159008214 2.44322902855122 0.305555555555556 1.3 1 3 SMALL CELL LUNG CANCER%KEGG%HSA05222 SMALL CELL LUNG CANCER 1.70039593578589e-06 4.15180007654389e-05 2.43781166928614 0.304878048780488 1.3 1 3 UBIQUITIN MEDIATED PROTEOLYSIS%KEGG%HSA04120 UBIQUITIN MEDIATED PROTEOLYSIS 2.49194367320858e-09 1.68493729903873e-07 2.43628803699284 0.3046875 1.3 1 3 BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY 0.0102191294556241 0.0420403188369434 2.43357199681782 0.304347826086957 1.3 1 3 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 OXIDATIVE STRESS RESPONSE 0.0102191294556241 0.0420403188369434 2.43357199681782 0.304347826086957 1.3 1 3 EPO%IOB%EPO EPO 7.98774855214107e-05 0.000948814996936757 2.4273639049892 0.303571428571429 1.3 1 3 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY 7.98774855214107e-05 0.000948814996936757 2.4273639049892 0.303571428571429 1.3 1 3 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY 7.98774855214107e-05 0.000948814996936757 2.4273639049892 0.303571428571429 1.3 1 3 ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY 0.00235700483553902 0.0137205778174755 2.42303705310865 0.303030303030303 1.3 1 3 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY 0.00235700483553902 0.0137205778174755 2.42303705310865 0.303030303030303 1.3 1 3 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA FORWARD SIGNALING 0.00235700483553902 0.0137205778174755 2.42303705310865 0.303030303030303 1.3 1 3 ACUTE MYELOID LEUKEMIA%KEGG%HSA05221 ACUTE MYELOID LEUKEMIA 0.000138209350654181 0.00148758390887785 2.41389351705919 0.30188679245283 1.3 1 3 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 CYTOSKELETAL REGULATION BY RHO GTPASE 3.43331293695199e-05 0.00050020144832831 2.41149878142718 0.301587301587302 1.3 1 3 EGFR1%IOB%EGFR1 EGFR1 1.01480448793077e-27 2.67603943467343e-24 2.40604290183119 0.300904977375566 1.3 1 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.17561761490685e-08 2.32092433563876e-06 2.39880668257757 0.3 1.3 1 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.73364760953169e-06 8.20469062194588e-05 2.39880668257757 0.3 1.3 1 3 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) 0.000239372421948149 0.00231217976804861 2.39880668257757 0.3 1.3 1 3 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY 0.000984238670521252 0.0072803923972015 2.39880668257757 0.3 1.3 1 3 CITRATE CYCLE (TCA CYCLE)%KEGG%HSA00020 CITRATE CYCLE (TCA CYCLE) 0.00415462618846228 0.021068748574952 2.39880668257757 0.3 1.3 1 3 BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY 0.00415462618846228 0.021068748574952 2.39880668257757 0.3 1.3 1 3 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 SIGNALING EVENTS MEDIATED BY STAT5 0.00415462618846228 0.021068748574952 2.39880668257757 0.3 1.3 1 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0183808429927187 0.0657745049636777 2.39880668257757 0.3 1.3 1 3 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS 0.000102120957563246 0.00117083897867078 2.38477857332273 0.298245614035088 1.3 1 3 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY 0.0017195271629927 0.0112237453683459 2.37719581156335 0.297297297297297 1.3 1 3 ID%NETPATH%ID ID 0.0017195271629927 0.0112237453683459 2.37719581156335 0.297297297297297 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0017195271629927 0.0112237453683459 2.37719581156335 0.297297297297297 1.3 1 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0017195271629927 0.0112237453683459 2.37719581156335 0.297297297297297 1.3 1 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0017195271629927 0.0112237453683459 2.37719581156335 0.297297297297297 1.3 1 3 EGFR1%NETPATH%EGFR1 EGFR1 3.19921825671632e-27 4.21816927148047e-24 2.37050217894833 0.29646017699115 1.3 1 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00735155754606126 0.0321932419180705 2.36919178526179 0.296296296296296 1.3 1 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00735155754606126 0.0321932419180705 2.36919178526179 0.296296296296296 1.3 1 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00735155754606126 0.0321932419180705 2.36919178526179 0.296296296296296 1.3 1 3 CHRONIC MYELOID LEUKEMIA%KEGG%HSA05220 CHRONIC MYELOID LEUKEMIA 1.88355116606414e-05 0.000306600273142663 2.3650206729638 0.295774647887324 1.3 1 3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY FANCONI ANEMIA PATHWAY 0.000720456417462364 0.00568815440972531 2.36246112678094 0.295454545454545 1.3 1 3 KITRECEPTOR%NETPATH%KITRECEPTOR KITRECEPTOR 3.8905500094006e-07 1.19295120637086e-05 2.35177125742899 0.294117647058824 1.3 1 3 VEGF SIGNALING PATHWAY%KEGG%HSA04370 VEGF SIGNALING PATHWAY 3.23157449321361e-05 0.000478745052730578 2.35177125742899 0.294117647058824 1.3 1 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0333662835088736 0.104613878205001 2.35177125742899 0.294117647058824 1.3 1 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0333662835088736 0.104613878205001 2.35177125742899 0.294117647058824 1.3 1 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0333662835088736 0.104613878205001 2.35177125742899 0.294117647058824 1.3 1 3 KITRECEPTOR%IOB%KITRECEPTOR KITRECEPTOR 2.60292119133734e-06 5.91715791513496e-05 2.33591661973845 0.292134831460674 1.3 1 3 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY 0.0130694513188728 0.0501661472021361 2.33217316361708 0.291666666666667 1.3 1 3 ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY 0.0130694513188728 0.0501661472021361 2.33217316361708 0.291666666666667 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0130694513188728 0.0501661472021361 2.33217316361708 0.291666666666667 1.3 1 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0130694513188728 0.0501661472021361 2.33217316361708 0.291666666666667 1.3 1 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0130694513188728 0.0501661472021361 2.33217316361708 0.291666666666667 1.3 1 3 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR ANDROGENRECEPTOR 2.39372293720276e-08 1.26244947708073e-06 2.32954979672887 0.291338582677165 1.3 1 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000223180112706663 0.00218782883720249 2.32611557098431 0.290909090909091 1.3 1 3 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 INTEGRIN SIGNALLING PATHWAY 8.75968572367386e-10 7.48069614553396e-08 2.32142582184926 0.290322580645161 1.3 1 3 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY NONCANONICAL WNT SIGNALING PATHWAY 0.00528575576496017 0.0250430935760346 2.32142582184926 0.290322580645161 1.3 1 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000384449412869256 0.00334585182091164 2.30654488709381 0.288461538461538 1.3 1 3 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T CELL ACTIVATION 0.000163378818581874 0.00170288515652333 2.30393862168467 0.288135593220339 1.3 1 3 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING A6B1 AND A6B4 INTEGRIN SIGNALING 0.0015780543751469 0.0105809569520826 2.28457779293102 0.285714285714286 1.3 1 3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY INSULIN PATHWAY 0.0015780543751469 0.0105809569520826 2.28457779293102 0.285714285714286 1.3 1 3 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING PRESENILIN ACTION IN NOTCH AND WNT SIGNALING 0.0015780543751469 0.0105809569520826 2.28457779293102 0.285714285714286 1.3 1 3 VITAMIN DIGESTION AND ABSORPTION%KEGG%HSA04977 VITAMIN DIGESTION AND ABSORPTION 0.0233690076158965 0.0801353356087375 2.28457779293102 0.285714285714286 1.3 1 3 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY 0.0233690076158965 0.0801353356087375 2.28457779293102 0.285714285714286 1.3 1 3 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY 0.0233690076158965 0.0801353356087375 2.28457779293102 0.285714285714286 1.3 1 3 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY 0.0233690076158965 0.0801353356087375 2.28457779293102 0.285714285714286 1.3 1 3 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF SIGNALING PATHWAY 3.3594868118076e-07 1.08036179545569e-05 2.28457779293101 0.285714285714286 1.3 1 3 IFN-ALPHA%IOB%IFN-ALPHA IFN-ALPHA 0.00380146666953736 0.0196173534394717 2.28457779293101 0.285714285714286 1.3 1 3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ERBB4 SIGNALING EVENTS 0.00380146666953736 0.0196173534394717 2.28457779293101 0.285714285714286 1.3 1 3 ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY 0.00930756003303439 0.0390207246535957 2.28457779293101 0.285714285714286 1.3 1 3 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION REGULATION OF RAS FAMILY ACTIVATION 0.00930756003303439 0.0390207246535957 2.28457779293101 0.285714285714286 1.3 1 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00930756003303439 0.0390207246535957 2.28457779293101 0.285714285714286 1.3 1 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 8.73768914338395e-05 0.00101503463749354 2.26752870492407 0.283582089552239 1.3 1 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.000149149366965249 0.00157954570557174 2.24888126491647 0.28125 1.3 1 3 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC 0.00664110042809209 0.0301941066015153 2.24888126491647 0.28125 1.3 1 3 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- AND CXCR2-MEDIATED SIGNALING EVENTS 0.00664110042809209 0.0301941066015153 2.24888126491647 0.28125 1.3 1 3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 P38 MAPK PATHWAY 0.00664110042809209 0.0301941066015153 2.24888126491647 0.28125 1.3 1 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.26857648681668e-07 7.57245088067797e-06 2.24681617651893 0.28099173553719 1.3 1 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.26857648681668e-07 7.57245088067797e-06 2.24681617651893 0.28099173553719 1.3 1 3 IL5%NETPATH%IL5 IL5 0.000350112951294919 0.00310201218750208 2.24449748077433 0.280701754385965 1.3 1 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.66553848535234e-05 0.000621503925151188 2.23888623707239 0.28 1.3 1 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.66553848535234e-05 0.000621503925151188 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.66553848535234e-05 0.000621503925151188 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.66553848535234e-05 0.000621503925151188 2.23888623707239 0.28 1.3 1 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.66553848535234e-05 0.000621503925151188 2.23888623707239 0.28 1.3 1 3 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS 0.000827117456975721 0.00628561594825641 2.23888623707239 0.28 1.3 1 3 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 PATHWAY 0.0164479095163502 0.0603242522873649 2.23888623707239 0.28 1.3 1 3 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT INSULIN-MEDIATED GLUCOSE TRANSPORT 0.0164479095163502 0.0603242522873649 2.23888623707239 0.28 1.3 1 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0164479095163502 0.0603242522873649 2.23888623707239 0.28 1.3 1 3 FOCAL ADHESION%KEGG%HSA04510 FOCAL ADHESION 8.94915549317342e-11 1.12375823978563e-08 2.23722903038322 0.27979274611399 1.3 1 3 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY CERAMIDE SIGNALING PATHWAY 0.00197040895832558 0.0118900879247244 2.23144807681634 0.27906976744186 1.3 1 3 COLORECTAL CANCER%KEGG%HSA05210 COLORECTAL CANCER 0.000254508606537768 0.0024228851820942 2.22839965048189 0.278688524590164 1.3 1 3 UNTITLED%PANTHER PATHWAY%P00019 UNTITLED 0.000254508606537768 0.0024228851820942 2.22839965048189 0.278688524590164 1.3 1 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.40807261040854e-05 0.000499282637424851 2.22674038045175 0.278481012658228 1.3 1 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.40807261040854e-05 0.000499282637424851 2.22674038045175 0.278481012658228 1.3 1 3 TCR%NETPATH%TCR TCR 3.15303397496357e-13 6.3958081476761e-11 2.22469974593887 0.278225806451613 1.3 1 3 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 7.92545682304225e-05 0.000948814996936757 2.22111729868293 0.277777777777778 1.3 1 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.92545682304225e-05 0.000948814996936757 2.22111729868293 0.277777777777778 1.3 1 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000599093884040762 0.00483122499148468 2.22111729868293 0.277777777777778 1.3 1 3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN DEGRADATION OF BETA CATENIN 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 HEDGEHOG SIGNALING PATHWAY 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0420902265000767 0.123187488657827 2.22111729868293 0.277777777777778 1.3 1 3 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS ARF6 TRAFFICKING EVENTS 0.00142041741844087 0.00962889648439219 2.21166573570981 0.276595744680851 1.3 1 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00142041741844087 0.00962889648439219 2.21166573570981 0.276595744680851 1.3 1 3 TSH%NETPATH%TSH TSH 5.77706240418611e-05 0.000721995903309895 2.20942720763723 0.276315789473684 1.3 1 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.29055139698589e-10 2.32314770532761e-08 2.20723531556616 0.276041666666667 1.3 1 3 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 TRANSCRIPTION FACTOR NETWORK 0.000434111392426666 0.00372506503166976 2.20579924834719 0.275862068965517 1.3 1 3 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY 0.0116260331248431 0.0461020290980622 2.20579924834719 0.275862068965517 1.3 1 3 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING RETINOIC ACID RECEPTORS-MEDIATED SIGNALING 0.0116260331248431 0.0461020290980622 2.20579924834719 0.275862068965517 1.3 1 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0116260331248431 0.0461020290980622 2.20579924834719 0.275862068965517 1.3 1 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0116260331248431 0.0461020290980622 2.20579924834719 0.275862068965517 1.3 1 3 AMOEBIASIS%KEGG%HSA05146 AMOEBIASIS 5.75422658203365e-06 0.000121391163974582 2.20298572889776 0.275510204081633 1.3 1 3 B CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04662 B CELL RECEPTOR SIGNALING PATHWAY 0.00013454558623852 0.00145408488078269 2.20180323521612 0.27536231884058 1.3 1 3 TNFALPHA%NETPATH%TNFALPHA TNFALPHA 2.59305619875265e-13 5.69824099675895e-11 2.20045574241611 0.275193798449612 1.3 1 3 ENDOMETRIAL CANCER%KEGG%HSA05213 ENDOMETRIAL CANCER 0.00102484196630916 0.00746549244518581 2.19498650693372 0.274509803921569 1.3 1 3 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B CELL ACTIVATION 0.00102484196630916 0.00746549244518581 2.19498650693372 0.274509803921569 1.3 1 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.27724718134363e-07 1.26301761961077e-05 2.19245772063541 0.274193548387097 1.3 1 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.27724718134363e-07 1.26301761961077e-05 2.19245772063541 0.274193548387097 1.3 1 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.27724718134363e-07 1.26301761961077e-05 2.19245772063541 0.274193548387097 1.3 1 3 RIG-I-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04622 RIG-I-LIKE RECEPTOR SIGNALING PATHWAY 0.000740061548291045 0.00580816161560562 2.18073334779779 0.272727272727273 1.3 1 3 ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY 0.00824763627529948 0.0352496221360854 2.18073334779779 0.272727272727273 1.3 1 3 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY 0.0291889192271109 0.0937529598074194 2.18073334779779 0.272727272727273 1.3 1 3 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY 0.0291889192271109 0.0937529598074194 2.18073334779779 0.272727272727273 1.3 1 3 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY 0.0291889192271109 0.0937529598074194 2.18073334779779 0.272727272727273 1.3 1 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0291889192271109 0.0937529598074194 2.18073334779779 0.272727272727273 1.3 1 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.17953992874549e-05 0.000654291519964556 2.17175913648998 0.271604938271605 1.3 1 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.17953992874549e-05 0.000654291519964556 2.17175913648998 0.271604938271605 1.3 1 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.77601998037517e-06 8.22922701508209e-05 2.1671462241355 0.271028037383178 1.3 1 3 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC)%KEGG%HSA05412 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC) 0.000120211539552653 0.0013319236546233 2.16108710142123 0.27027027027027 1.3 1 3 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- AND CXCR1-MEDIATED SIGNALING EVENTS 0.0203996577351682 0.0713446915751173 2.15277522795423 0.269230769230769 1.3 1 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0203996577351682 0.0713446915751173 2.15277522795423 0.269230769230769 1.3 1 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0203996577351682 0.0713446915751173 2.15277522795423 0.269230769230769 1.3 1 3 HEPATITIS C%KEGG%HSA05160 HEPATITIS C 1.47115944646364e-06 3.65985609464587e-05 2.15019086393507 0.26890756302521 1.3 1 3 VASOPRESSIN-REGULATED WATER REABSORPTION%KEGG%HSA04962 VASOPRESSIN-REGULATED WATER REABSORPTION 0.00418764465886682 0.0211954298760687 2.14527426897181 0.268292682926829 1.3 1 3 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR SIGNALING PATHWAY 0.000654951318421268 0.00524956421482335 2.13227260673561 0.266666666666667 1.3 1 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0143429083744362 0.0538012082267256 2.13227260673561 0.266666666666667 1.3 1 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0143429083744362 0.0538012082267256 2.13227260673561 0.266666666666667 1.3 1 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.03733181734609e-10 2.96646074160802e-08 2.13227260673561 0.266666666666667 1.3 1 3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0.00299477605612184 0.0163503612008143 2.13227260673561 0.266666666666667 1.3 1 3 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF SIGNALING PATHWAY 0.00299477605612184 0.0163503612008143 2.13227260673561 0.266666666666667 1.3 1 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00299477605612184 0.0163503612008143 2.13227260673561 0.266666666666667 1.3 1 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.06056410831189e-07 9.96383648594873e-06 2.12843758406163 0.266187050359712 1.3 1 3 ENDOCYTOSIS%KEGG%HSA04144 ENDOCYTOSIS 2.91621713676193e-09 1.9225161474103e-07 2.12660166895174 0.265957446808511 1.3 1 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.000106564990135165 0.00120605956646537 2.12552490861303 0.265822784810127 1.3 1 3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0.0101328677666534 0.0418159190933725 2.11659413168609 0.264705882352941 1.3 1 3 REGULATION OF ACTIN CYTOSKELETON%KEGG%HSA04810 REGULATION OF ACTIN CYTOSKELETON 1.38567934710393e-09 1.04401041094659e-07 2.10840388352589 0.263681592039801 1.3 1 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.96112945843836e-05 0.000441158100672427 2.10421638822593 0.263157894736842 1.3 1 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.96112945843836e-05 0.000441158100672427 2.10421638822593 0.263157894736842 1.3 1 3 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY NOTCH SIGNALING PATHWAY 0.00110750784102038 0.00790913374871908 2.10421638822593 0.263157894736842 1.3 1 3 HEDGEHOG%IOB%HEDGEHOG HEDGEHOG 0.00718662923278254 0.0319042782606861 2.10421638822593 0.263157894736842 1.3 1 3 HEDGEHOG%NETPATH%HEDGEHOG HEDGEHOG 0.00718662923278254 0.0319042782606861 2.10421638822593 0.263157894736842 1.3 1 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00718662923278254 0.0319042782606861 2.10421638822593 0.263157894736842 1.3 1 3 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY 0.052060888143586 0.14466234144851 2.10421638822593 0.263157894736842 1.3 1 3 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY ARF1 PATHWAY 0.052060888143586 0.14466234144851 2.10421638822593 0.263157894736842 1.3 1 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.052060888143586 0.14466234144851 2.10421638822593 0.263157894736842 1.3 1 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.052060888143586 0.14466234144851 2.10421638822593 0.263157894736842 1.3 1 3 TIGHT JUNCTION%KEGG%HSA04530 TIGHT JUNCTION 3.62803209526409e-06 8.03959717244657e-05 2.10064991977131 0.26271186440678 1.3 1 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.15222227299083e-05 0.000342600896455706 2.0999654460275 0.262626262626263 1.3 1 3 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY 0.00511362830792872 0.0243845169041737 2.09419631018676 0.261904761904762 1.3 1 3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS BETA3 INTEGRIN CELL SURFACE INTERACTIONS 0.00511362830792872 0.0243845169041737 2.09419631018676 0.261904761904762 1.3 1 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.40429693128108e-06 3.61950682182806e-05 2.09126736429839 0.261538461538462 1.3 1 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000574728012264459 0.00470670114391732 2.09126736429839 0.261538461538462 1.3 1 3 FC GAMMA R-MEDIATED PHAGOCYTOSIS%KEGG%HSA04666 FC GAMMA R-MEDIATED PHAGOCYTOSIS 6.80607642300747e-05 0.000834773187324218 2.08986945830621 0.261363636363636 1.3 1 3 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-MEDIATED SIGNALING EVENTS 0.00364857993658034 0.0190520896886383 2.08591885441527 0.260869565217391 1.3 1 3 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY 0.00364857993658034 0.0190520896886383 2.08591885441527 0.260869565217391 1.3 1 3 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK NOTCH-MEDIATED HES HEY NETWORK 0.00364857993658034 0.0190520896886383 2.08591885441527 0.260869565217391 1.3 1 3 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF RECEPTOR SIGNALING PATHWAY 0.00364857993658034 0.0190520896886383 2.08591885441527 0.260869565217391 1.3 1 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00364857993658034 0.0190520896886383 2.08591885441527 0.260869565217391 1.3 1 3 CCR1%IOB%CCR1 CCR1 0.0358841391464592 0.107530085146833 2.08591885441527 0.260869565217391 1.3 1 3 MUCIN TYPE O-GLYCAN BIOSYNTHESIS%KEGG%HSA00512 MUCIN TYPE O-GLYCAN BIOSYNTHESIS 0.0358841391464592 0.107530085146833 2.08591885441527 0.260869565217391 1.3 1 3 GLYCOSYLPHOSPHATIDYLINOSITOL(GPI)-ANCHOR BIOSYNTHESIS%KEGG%HSA00563 GLYCOSYLPHOSPHATIDYLINOSITOL(GPI)-ANCHOR BIOSYNTHESIS 0.0358841391464592 0.107530085146833 2.08591885441527 0.260869565217391 1.3 1 3 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY CANONICAL NF-KAPPAB PATHWAY 0.0358841391464592 0.107530085146833 2.08591885441527 0.260869565217391 1.3 1 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0358841391464592 0.107530085146833 2.08591885441527 0.260869565217391 1.3 1 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0358841391464592 0.107530085146833 2.08591885441527 0.260869565217391 1.3 1 3 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY P53 PATHWAY 0.00186994157851965 0.0118739679082301 2.07304281210407 0.259259259259259 1.3 1 3 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0249664928013556 0.0840825562160598 2.07304281210407 0.259259259259259 1.3 1 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.000113467770689412 0.00126250848653156 2.06955870653751 0.258823529411765 1.3 1 3 NEUROTROPHIN SIGNALING PATHWAY%KEGG%HSA04722 NEUROTROPHIN SIGNALING PATHWAY 5.2913656994387e-06 0.000112526865721128 2.06563908777513 0.258333333333333 1.3 1 3 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS 0.000694938511509833 0.00551973751461274 2.05958149514235 0.257575757575758 1.3 1 3 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 0.000694938511509833 0.00551973751461274 2.05958149514235 0.257575757575758 1.3 1 3 RENAL CELL CARCINOMA%KEGG%HSA05211 RENAL CELL CARCINOMA 0.000694938511509833 0.00551973751461274 2.05958149514235 0.257575757575758 1.3 1 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0123245066079628 0.0481903421245707 2.05612001363791 0.257142857142857 1.3 1 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0123245066079628 0.0481903421245707 2.05612001363791 0.257142857142857 1.3 1 3 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM%KEGG%HSA04141 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM 3.05852613659122e-07 9.96383648594873e-06 2.05026212186117 0.256410256410256 1.3 1 3 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY 0.00872141455134676 0.0370941454385506 2.05026212186117 0.256410256410256 1.3 1 3 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING 0.00872141455134676 0.0370941454385506 2.05026212186117 0.256410256410256 1.3 1 3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 UBIQUITIN PROTEASOME PATHWAY 0.00872141455134676 0.0370941454385506 2.05026212186117 0.256410256410256 1.3 1 3 MAPK SIGNALING PATHWAY%KEGG%HSA04010 MAPK SIGNALING PATHWAY 1.11748220442142e-10 1.28121764046056e-08 2.04698170246619 0.256 1.3 1 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.20733041980233e-09 9.36391269711398e-08 2.04382632147864 0.255605381165919 1.3 1 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.20733041980233e-09 9.36391269711398e-08 2.04382632147864 0.255605381165919 1.3 1 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9.89360934253168e-05 0.00113927719808978 2.0434279147883 0.255555555555556 1.3 1 3 RIBOSOME%KEGG%HSA03010 RIBOSOME 0.004412521371371 0.0213893728976201 2.04153760219367 0.25531914893617 1.3 1 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.004412521371371 0.0213893728976201 2.04153760219367 0.25531914893617 1.3 1 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00315145072710984 0.0170294581298948 2.03820175643845 0.254901960784314 1.3 1 3 LYSOSOME%KEGG%HSA04142 LYSOSOME 1.04941238661986e-05 0.000194880314332153 2.03288701913353 0.254237288135593 1.3 1 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.62978931567669e-06 0.000152422382010905 2.03177615190996 0.254098360655738 1.3 1 3 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION%KEGG%HSA05120 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 0.00116209283781445 0.00825994289303693 2.03073581593868 0.253968253968254 1.3 1 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.32785739953043e-11 4.61871576976933e-09 2.0284027095325 0.253676470588235 1.3 1 3 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 APOPTOSIS SIGNALING PATHWAY 8.59136645911934e-05 0.00100245280321671 2.0200477326969 0.252631578947368 1.3 1 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.37864064931495e-05 0.000375597328876858 2.01701462799315 0.252252252252252 1.3 1 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.5555482774236e-06 5.85998331092699e-05 2.01338690384208 0.251798561151079 1.3 1 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.23395454945094e-17 4.10973453672553e-14 2.00796971934744 0.251121076233184 1.3 1 3 PROSTATE CANCER%KEGG%HSA05215 PROSTATE CANCER 0.000270829682472078 0.00255977732142964 1.99900556881464 0.25 1.3 1 3 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR SIGNALING IN NAIVE CD8+ T CELLS 0.00378167561449814 0.0196173534394717 1.99900556881464 0.25 1.3 1 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.00378167561449814 0.0196173534394717 1.99900556881464 0.25 1.3 1 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00529922116625988 0.0250430935760346 1.99900556881464 0.25 1.3 1 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.00744576622542329 0.0324001411492429 1.99900556881464 0.25 1.3 1 3 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0.0104951797813116 0.0427265950926745 1.99900556881464 0.25 1.3 1 3 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-GAMMA PATHWAY 0.0104951797813116 0.0427265950926745 1.99900556881464 0.25 1.3 1 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0148501405326871 0.0552324690898391 1.99900556881464 0.25 1.3 1 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0148501405326871 0.0552324690898391 1.99900556881464 0.25 1.3 1 3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY 0.0211105962913803 0.0733012094434393 1.99900556881464 0.25 1.3 1 3 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK GLYPICAN 1 NETWORK 0.043489035088988 0.126022621461166 1.99900556881464 0.25 1.3 1 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.043489035088988 0.126022621461166 1.99900556881464 0.25 1.3 1 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.043489035088988 0.126022621461166 1.99900556881464 0.25 1.3 1 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.043489035088988 0.126022621461166 1.99900556881464 0.25 1.3 1 3 NGF%IOB%NGF NGF 0.0632875698605418 0.168214671873417 1.99900556881464 0.25 1.3 1 3 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY CANONICAL WNT SIGNALING PATHWAY 0.0632875698605418 0.168214671873417 1.99900556881464 0.25 1.3 1 3 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 SYNAPTIC_VESICLE_TRAFFICKING 0.0632875698605418 0.168214671873417 1.99900556881464 0.25 1.3 1 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0632875698605418 0.168214671873417 1.99900556881464 0.25 1.3 1 3 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 SIGNALING 0.00270494123023933 0.0150166947876655 1.99900556881464 0.25 1.3 1 3 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING ALPHA-SYNUCLEIN SIGNALING 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS BETA2 INTEGRIN CELL SURFACE INTERACTIONS 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 GENERAL TRANSCRIPTION REGULATION 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 INTERFERON-GAMMA SIGNALING PATHWAY 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 AXON GUIDANCE MEDIATED BY NETRIN 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0301861370574627 0.0954446563795314 1.99900556881464 0.25 1.3 1 3 AXON GUIDANCE%KEGG%HSA04360 AXON GUIDANCE 1.29436626621901e-05 0.000226042638676789 1.98301352426412 0.248 1.3 1 3 GAP JUNCTION%KEGG%HSA04540 GAP JUNCTION 0.000446453237718673 0.00376239673024969 1.97432648771816 0.246913580246914 1.3 1 3 RNA DEGRADATION%KEGG%HSA03018 RNA DEGRADATION 0.00119242501194483 0.00843009318096117 1.97003447361443 0.246376811594203 1.3 1 3 TNFALPHA%IOB%TNFALPHA TNFALPHA 4.43472759063463e-08 1.77187525098538e-06 1.9694636145957 0.246305418719212 1.3 1 3 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE REGULATION OF TELOMERASE 0.00165867136617903 0.0109897396799349 1.96825163698672 0.246153846153846 1.3 1 3 WNT%IOB%WNT WNT 4.00616416009331e-05 0.000564933416586421 1.96393529567754 0.245614035087719 1.3 1 3 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY COREGULATION OF ANDROGEN RECEPTOR ACTIVITY 0.00322503582207806 0.0173914508442123 1.96393529567754 0.245614035087719 1.3 1 3 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 HUNTINGTON DISEASE 7.60955170850998e-05 0.000924718334347503 1.96128848261059 0.245283018867925 1.3 1 3 BCR%NETPATH%BCR BCR 1.96426530713196e-06 4.666457310727e-05 1.96031513845048 0.245161290322581 1.3 1 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00632189161355739 0.0289927446694797 1.95820953679801 0.244897959183673 1.3 1 3 BDNF%IOB%BDNF BDNF 0.00888579245666788 0.0374909355331731 1.95458322284098 0.244444444444444 1.3 1 3 N-GLYCAN BIOSYNTHESIS%KEGG%HSA00510 N-GLYCAN BIOSYNTHESIS 0.00888579245666788 0.0374909355331731 1.95458322284098 0.244444444444444 1.3 1 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00888579245666788 0.0374909355331731 1.95458322284098 0.244444444444444 1.3 1 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00888579245666788 0.0374909355331731 1.95458322284098 0.244444444444444 1.3 1 3 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING 0.000382503239051707 0.00333993722311044 1.9525170672143 0.244186046511628 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0125298685304873 0.0484476001684676 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0125298685304873 0.0484476001684676 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0125298685304873 0.0484476001684676 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0125298685304873 0.0484476001684676 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0125298685304873 0.0484476001684676 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0125298685304873 0.0484476001684676 1.95024933542892 0.24390243902439 1.3 1 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.69097055278362e-06 4.15180007654389e-05 1.94903042959427 0.24375 1.3 1 3 PARKINSON DISEASE%PANTHER PATHWAY%P00049 PARKINSON DISEASE 0.000733877541930846 0.00577682112857206 1.94774901576811 0.243589743589744 1.3 1 3 WNT%NETPATH%WNT WNT 4.73950359008333e-05 0.000628043767188429 1.94685759745426 0.243478260869565 1.3 1 3 FAS%IOB%FAS FAS 6.52960148398522e-05 0.000808383056960987 1.94497839127911 0.243243243243243 1.3 1 3 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR SIGNALING PATHWAY 0.0177368987131901 0.0644245205326201 1.94497839127911 0.243243243243243 1.3 1 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.33306771321673e-08 2.03815935648587e-06 1.94189112399136 0.242857142857143 1.3 1 3 T CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04660 T CELL RECEPTOR SIGNALING PATHWAY 0.000124129602905773 0.00136958059775114 1.94078210564528 0.242718446601942 1.3 1 3 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY 0.0252267434965261 0.084312956400937 1.93842964248692 0.242424242424242 1.3 1 3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA 0.0252267434965261 0.084312956400937 1.93842964248692 0.242424242424242 1.3 1 3 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 SIGNALING EVENTS MEDIATED BY PI3K 0.0252267434965261 0.084312956400937 1.93842964248692 0.242424242424242 1.3 1 3 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK 0.0252267434965261 0.084312956400937 1.93842964248692 0.242424242424242 1.3 1 3 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA 0.0252267434965261 0.084312956400937 1.93842964248692 0.242424242424242 1.3 1 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0252267434965261 0.084312956400937 1.93842964248692 0.242424242424242 1.3 1 3 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS INTEGRINS IN ANGIOGENESIS 0.0027402582656807 0.0151389981286425 1.93452151820771 0.241935483870968 1.3 1 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.0027402582656807 0.0151389981286425 1.93452151820771 0.241935483870968 1.3 1 3 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-MEDIATED SIGNALING EVENTS 0.00382405199036137 0.0196841012460593 1.93007434230379 0.241379310344828 1.3 1 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0360916246723871 0.107941057897624 1.93007434230379 0.241379310344828 1.3 1 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000625743511765965 0.00503074890404527 1.92675235548399 0.240963855421687 1.3 1 3 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY 0.0053471837074011 0.0251795061364584 1.92496832552521 0.240740740740741 1.3 1 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0053471837074011 0.0251795061364584 1.92496832552521 0.240740740740741 1.3 1 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.69221929331236e-07 1.61401959961986e-05 1.92254087492555 0.240437158469945 1.3 1 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000146352883794239 0.00155617965550568 1.92212073924484 0.240384615384615 1.3 1 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00749426560178791 0.0325574602832203 1.91904534606205 0.24 1.3 1 3 HOMOLOGOUS RECOMBINATION%KEGG%HSA03440 HOMOLOGOUS RECOMBINATION 0.0520283379014 0.14466234144851 1.91904534606205 0.24 1.3 1 3 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY REELIN SIGNALING PATHWAY 0.0520283379014 0.14466234144851 1.91904534606205 0.24 1.3 1 3 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS 0.0520283379014 0.14466234144851 1.91904534606205 0.24 1.3 1 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0520283379014 0.14466234144851 1.91904534606205 0.24 1.3 1 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0520283379014 0.14466234144851 1.91904534606205 0.24 1.3 1 3 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY 0.0105317735344097 0.0427265950926745 1.912092283214 0.239130434782609 1.3 1 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0105317735344097 0.0427265950926745 1.912092283214 0.239130434782609 1.3 1 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0105317735344097 0.0427265950926745 1.912092283214 0.239130434782609 1.3 1 3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS BETA1 INTEGRIN CELL SURFACE INTERACTIONS 0.00232190286471747 0.0136063507872444 1.90949785677816 0.238805970149254 1.3 1 3 RAS PATHWAY%PANTHER PATHWAY%P04393 RAS PATHWAY 0.00232190286471747 0.0136063507872444 1.90949785677816 0.238805970149254 1.3 1 3 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 SIGNALING EVENTS 0.0148474436000368 0.0552324690898391 1.90381482744251 0.238095238095238 1.3 1 3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS CLASS I PI3K SIGNALING EVENTS 0.0148474436000368 0.0552324690898391 1.90381482744251 0.238095238095238 1.3 1 3 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES 0.0148474436000368 0.0552324690898391 1.90381482744251 0.238095238095238 1.3 1 3 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY 0.0757621205619935 0.191181542509069 1.90381482744251 0.238095238095238 1.3 1 3 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY 0.0757621205619935 0.191181542509069 1.90381482744251 0.238095238095238 1.3 1 3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY 0.0757621205619935 0.191181542509069 1.90381482744251 0.238095238095238 1.3 1 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0757621205619935 0.191181542509069 1.90381482744251 0.238095238095238 1.3 1 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0757621205619935 0.191181542509069 1.90381482744251 0.238095238095238 1.3 1 3 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS)%KEGG%HSA05142 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS) 0.000237270356003431 0.00230030120875385 1.90004489709114 0.237623762376238 1.3 1 3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING REGULATION OF NUCLEAR SMAD2 3 SIGNALING 0.00102024540821105 0.00746549244518581 1.89905529037391 0.2375 1.3 1 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.08251231961485e-06 0.000127298293546225 1.89649246272158 0.237179487179487 1.3 1 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.34399232046092e-06 0.000165436900368838 1.89379474940334 0.236842105263158 1.3 1 3 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY 0.0210111202760751 0.073288788582024 1.89379474940334 0.236842105263158 1.3 1 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.000452137978181565 0.0037850407887771 1.89153215113643 0.236559139784946 1.3 1 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.01685387135335e-07 3.62357251183621e-06 1.88996890142475 0.236363636363636 1.3 1 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.78012565813091e-05 0.000630259568024561 1.88882415950989 0.236220472440945 1.3 1 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00196323473947225 0.0118739679082301 1.88794970388049 0.236111111111111 1.3 1 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.4385420855961e-16 7.58687095943384e-14 1.88670188517337 0.235955056179775 1.3 1 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 6.57185070408526e-05 0.000809811696573496 1.88524102424795 0.235772357723577 1.3 1 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.15668368644851e-05 0.000342600896455706 1.88477667916809 0.235714285714286 1.3 1 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 7.11406639885159e-06 0.00014430610072132 1.88441289289533 0.235668789808917 1.3 1 3 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA 0.0298710129518715 0.0954446563795314 1.88141700594319 0.235294117647059 1.3 1 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0298710129518715 0.0954446563795314 1.88141700594319 0.235294117647059 1.3 1 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0298710129518715 0.0954446563795314 1.88141700594319 0.235294117647059 1.3 1 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.00086409716761863 0.00649180692595535 1.88141700594319 0.235294117647059 1.3 1 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.00086409716761863 0.00649180692595535 1.88141700594319 0.235294117647059 1.3 1 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.00086409716761863 0.00649180692595535 1.88141700594319 0.235294117647059 1.3 1 3 NON-SMALL CELL LUNG CANCER%KEGG%HSA05223 NON-SMALL CELL LUNG CANCER 0.00883051633245811 0.0374909355331731 1.88141700594319 0.235294117647059 1.3 1 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0037971840704467 0.0196173534394717 1.87406772076372 0.234375 1.3 1 3 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN REGULATION OF RETINOBLASTOMA PROTEIN 0.00529319555815841 0.0250430935760346 1.86573853089366 0.233333333333333 1.3 1 3 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY 0.0427107991978505 0.124588913146827 1.86573853089366 0.233333333333333 1.3 1 3 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY 0.0427107991978505 0.124588913146827 1.86573853089366 0.233333333333333 1.3 1 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0427107991978505 0.124588913146827 1.86573853089366 0.233333333333333 1.3 1 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.00229862534648149 0.0135300782113207 1.8620873791698 0.232876712328767 1.3 1 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.67576310961681e-06 0.000184891212464199 1.86070958606646 0.232704402515723 1.3 1 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.5545845301736e-11 2.41143494474576e-09 1.86003726723929 0.232620320855615 1.3 1 3 NUCLEOTIDE EXCISION REPAIR%KEGG%HSA03420 NUCLEOTIDE EXCISION REPAIR 0.017469665915395 0.0636291561034483 1.85954006401362 0.232558139534884 1.3 1 3 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 P53 PATHWAY FEEDBACK LOOPS 2 0.017469665915395 0.0636291561034483 1.85954006401362 0.232558139534884 1.3 1 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000447603403357582 0.00376239673024969 1.85766174071663 0.232323232323232 1.3 1 3 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY 0.00739215880245699 0.0322200376232712 1.85621945675645 0.232142857142857 1.3 1 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.12523193553209e-05 0.000207499063915952 1.84908015115354 0.23125 1.3 1 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0103451685478461 0.0424264532825351 1.84523590967505 0.230769230769231 1.3 1 3 ID%IOB%ID ID 0.0615169419512695 0.165362054969926 1.84523590967505 0.230769230769231 1.3 1 3 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS INTEGRIN FAMILY CELL SURFACE INTERACTIONS 0.0615169419512695 0.165362054969926 1.84523590967505 0.230769230769231 1.3 1 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0615169419512695 0.165362054969926 1.84523590967505 0.230769230769231 1.3 1 3 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK GLUCOCORTICOID RECEPTOR REGULATORY NETWORK 0.00193423177354845 0.0118739679082301 1.84523590967505 0.230769230769231 1.3 1 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0246980319934937 0.0839287504727355 1.84523590967505 0.230769230769231 1.3 1 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000520991227289994 0.00432029517724439 1.83908512330947 0.23 1.3 1 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000319333447842947 0.00292534673043687 1.8339500631327 0.229357798165138 1.3 1 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0145130467174966 0.0543620798210776 1.83242177141342 0.229166666666667 1.3 1 3 PATHWAYS IN CANCER%KEGG%HSA05200 PATHWAYS IN CANCER 2.24081837431231e-09 1.59703731163826e-07 1.83134703723664 0.229032258064516 1.3 1 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 5.42474564009839e-05 0.000681193059663783 1.82766223434481 0.228571428571429 1.3 1 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000439323179692566 0.00372506503166976 1.82766223434481 0.228571428571429 1.3 1 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00371885230688279 0.0193806591566204 1.82766223434481 0.228571428571429 1.3 1 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0350699777945111 0.106420634573217 1.82766223434481 0.228571428571429 1.3 1 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0350699777945111 0.106420634573217 1.82766223434481 0.228571428571429 1.3 1 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.000269410019165261 0.00255551877891652 1.82365420312914 0.228070175438596 1.3 1 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00136606572402261 0.00934258691923753 1.81727778983149 0.227272727272727 1.3 1 3 NITROGEN METABOLISM%KEGG%HSA00910 NITROGEN METABOLISM 0.0894601209546059 0.21965208469022 1.81727778983149 0.227272727272727 1.3 1 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0894601209546059 0.21965208469022 1.81727778983149 0.227272727272727 1.3 1 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0894601209546059 0.21965208469022 1.81727778983149 0.227272727272727 1.3 1 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0894601209546059 0.21965208469022 1.81727778983149 0.227272727272727 1.3 1 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0894601209546059 0.21965208469022 1.81727778983149 0.227272727272727 1.3 1 3 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-BETA SIGNALING PATHWAY 0.00188608744410024 0.0118739679082301 1.80862408607039 0.226190476190476 1.3 1 3 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR SIGNALING IN NAIVE CD4+ T CELLS 0.00718528070033657 0.0319042782606861 1.80555341699387 0.225806451612903 1.3 1 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00718528070033657 0.0319042782606861 1.80555341699387 0.225806451612903 1.3 1 3 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0.0500659257856024 0.140450900315568 1.80555341699387 0.225806451612903 1.3 1 3 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS SIGNALING PATHWAY 0.0500659257856024 0.140450900315568 1.80555341699387 0.225806451612903 1.3 1 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0500659257856024 0.140450900315568 1.80555341699387 0.225806451612903 1.3 1 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0500659257856024 0.140450900315568 1.80555341699387 0.225806451612903 1.3 1 3 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM%KEGG%HSA04070 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 0.00431492877111406 0.021352824104098 1.80192051273432 0.225352112676056 1.3 1 3 LYSINE DEGRADATION%KEGG%HSA00310 LYSINE DEGRADATION 0.0288214407002562 0.093025874083936 1.79910501193317 0.225 1.3 1 3 BASAL TRANSCRIPTION FACTORS%KEGG%HSA03022 BASAL TRANSCRIPTION FACTORS 0.0288214407002562 0.093025874083936 1.79910501193317 0.225 1.3 1 3 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 SIGNALING EVENTS 0.0288214407002562 0.093025874083936 1.79910501193317 0.225 1.3 1 3 BLOOD COAGULATION%PANTHER PATHWAY%P00011 BLOOD COAGULATION 0.0288214407002562 0.093025874083936 1.79910501193317 0.225 1.3 1 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0288214407002562 0.093025874083936 1.79910501193317 0.225 1.3 1 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000161228882022803 0.00168714508688148 1.79755539521316 0.224806201550388 1.3 1 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.0015809241710734 0.0105809569520826 1.79685893826035 0.224719101123595 1.3 1 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0168841705633738 0.0617525073170829 1.79502540873151 0.224489795918367 1.3 1 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.0100098193194895 0.0416996738475417 1.79221188928209 0.224137931034483 1.3 1 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.0100098193194895 0.0416996738475417 1.79221188928209 0.224137931034483 1.3 1 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.90887081354827e-06 0.000172740384818579 1.79145854254427 0.224043715846995 1.3 1 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.35723593909289e-05 0.000979468052061687 1.78931966998793 0.223776223776224 1.3 1 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00360336555971759 0.0190422344308122 1.78858392999204 0.223684210526316 1.3 1 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00218029676611768 0.0128714857055214 1.78734615564603 0.223529411764706 1.3 1 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00218029676611768 0.0128714857055214 1.78734615564603 0.223529411764706 1.3 1 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00218029676611768 0.0128714857055214 1.78734615564603 0.223529411764706 1.3 1 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00218029676611768 0.0128714857055214 1.78734615564603 0.223529411764706 1.3 1 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00218029676611768 0.0128714857055214 1.78734615564603 0.223529411764706 1.3 1 3 OXIDATIVE PHOSPHORYLATION%KEGG%HSA00190 OXIDATIVE PHOSPHORYLATION 0.000807583215793786 0.00617274475376294 1.78551953719366 0.223300970873786 1.3 1 3 OSTEOCLAST DIFFERENTIATION%KEGG%HSA04380 OSTEOCLAST DIFFERENTIATION 0.000493712539205084 0.00410700304695207 1.78482640072736 0.223214285714286 1.3 1 3 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY 0.0719599274226735 0.182811491920607 1.77689383894635 0.222222222222222 1.3 1 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0719599274226735 0.182811491920607 1.77689383894635 0.222222222222222 1.3 1 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0719599274226735 0.182811491920607 1.77689383894635 0.222222222222222 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0719599274226735 0.182811491920607 1.77689383894635 0.222222222222222 1.3 1 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0719599274226735 0.182811491920607 1.77689383894635 0.222222222222222 1.3 1 3 TOXOPLASMOSIS%KEGG%HSA05145 TOXOPLASMOSIS 0.000414513054440404 0.00359562804131364 1.77689383894634 0.222222222222222 1.3 1 3 SYSTEMIC LUPUS ERYTHEMATOSUS%KEGG%HSA05322 SYSTEMIC LUPUS ERYTHEMATOSUS 0.00110973814449225 0.00790913374871908 1.77689383894634 0.222222222222222 1.3 1 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00300875622947724 0.0163927482998585 1.77689383894634 0.222222222222222 1.3 1 3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION 0.00498684135158314 0.0238662443632028 1.77689383894634 0.222222222222222 1.3 1 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00498684135158314 0.0238662443632028 1.77689383894634 0.222222222222222 1.3 1 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.00182381649954804 0.0117302539251419 1.77689383894634 0.222222222222222 1.3 1 3 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY 0.0237127514922475 0.0812084749156579 1.77689383894634 0.222222222222222 1.3 1 3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF SIGNALING PATHWAY 0.0015254380055153 0.0103143077449842 1.76754176610979 0.221052631578947 1.3 1 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.00251216212198887 0.0143388993845988 1.76656306081294 0.22093023255814 1.3 1 3 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS DIRECT P53 EFFECTORS 0.000292001734321003 0.00271129779367776 1.7629025488759 0.220472440944882 1.3 1 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000778439273748161 0.00601977819611115 1.76059206060739 0.220183486238532 1.3 1 3 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM%KEGG%HSA00520 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 0.0195326052961288 0.0685851932967931 1.75912490055688 0.22 1.3 1 3 ENDOCRINE AND OTHER FACTOR-REGULATED CALCIUM REABSORPTION%KEGG%HSA04961 ENDOCRINE AND OTHER FACTOR-REGULATED CALCIUM REABSORPTION 0.0334034453730038 0.104613878205001 1.75522440188602 0.219512195121951 1.3 1 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0334034453730038 0.104613878205001 1.75522440188602 0.219512195121951 1.3 1 3 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF RECEPTOR SIGNALING PATHWAY 0.00106698625614316 0.00766660151893601 1.75150964124711 0.219047619047619 1.3 1 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.04111379875083e-05 0.000566830696133295 1.75060842712761 0.218934911242604 1.3 1 3 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM PATHWAY 0.0581734180439845 0.160631731290039 1.74912987271281 0.21875 1.3 1 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.40642558360694e-07 1.2768949740628e-05 1.74625773827486 0.218390804597701 1.3 1 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00288533598774356 0.0158513145826662 1.74625773827486 0.218390804597701 1.3 1 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0161079911585793 0.0594912782705513 1.74458667823823 0.218181818181818 1.3 1 3 MRNA SURVEILLANCE PATHWAY%KEGG%HSA03015 MRNA SURVEILLANCE PATHWAY 0.00477361043874157 0.0230549647013947 1.74272280358199 0.217948717948718 1.3 1 3 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION 0.00477361043874157 0.0230549647013947 1.74272280358199 0.217948717948718 1.3 1 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.61881442778286e-05 0.000621503925151188 1.74031073049745 0.217647058823529 1.3 1 3 MELANOMA%KEGG%HSA05218 MELANOMA 0.00794019908196528 0.0339907548362702 1.73826571201273 0.217391304347826 1.3 1 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00794019908196528 0.0339907548362702 1.73826571201273 0.217391304347826 1.3 1 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00240521244834945 0.013970363934576 1.73826571201273 0.217391304347826 1.3 1 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0273741342583136 0.0888985123635134 1.73826571201273 0.217391304347826 1.3 1 3 ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY 0.104342338123536 0.243927965985606 1.73826571201273 0.217391304347826 1.3 1 3 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY 0.104342338123536 0.243927965985606 1.73826571201273 0.217391304347826 1.3 1 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.104342338123536 0.243927965985606 1.73826571201273 0.217391304347826 1.3 1 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.104342338123536 0.243927965985606 1.73826571201273 0.217391304347826 1.3 1 3 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY MTOR SIGNALING PATHWAY 0.0132984577155006 0.0508969999938679 1.73247149297269 0.216666666666667 1.3 1 3 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-MEDIATED SIGNALING EVENTS 0.0472222949665749 0.135944532562072 1.72886968113698 0.216216216216216 1.3 1 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0472222949665749 0.135944532562072 1.72886968113698 0.216216216216216 1.3 1 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.0033036857705073 0.0175641519694108 1.72641390033991 0.215909090909091 1.3 1 3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY 0.00167250277819154 0.0110536085866944 1.72463225544792 0.215686274509804 1.3 1 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.0224756797611382 0.077474990235453 1.72463225544792 0.215686274509804 1.3 1 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.0224756797611382 0.077474990235453 1.72463225544792 0.215686274509804 1.3 1 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.0224756797611382 0.077474990235453 1.72463225544792 0.215686274509804 1.3 1 3 PHAGOSOME%KEGG%HSA04145 PHAGOSOME 0.000436822345755376 0.00372506503166976 1.72222018236338 0.215384615384615 1.3 1 3 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK 0.0109902998536962 0.0443140989513713 1.72222018236338 0.215384615384615 1.3 1 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0109902998536962 0.0443140989513713 1.72222018236338 0.215384615384615 1.3 1 3 MELANOGENESIS%KEGG%HSA04916 MELANOGENESIS 0.00274993557209699 0.0151389981286425 1.7195746828513 0.21505376344086 1.3 1 3 NATURAL KILLER CELL MEDIATED CYTOTOXICITY%KEGG%HSA04650 NATURAL KILLER CELL MEDIATED CYTOTOXICITY 0.00274993557209699 0.0151389981286425 1.7195746828513 0.21505376344086 1.3 1 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.14068404994256e-05 0.000208887766645731 1.71343334469826 0.214285714285714 1.3 1 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00909147547516959 0.0382974773610578 1.71343334469826 0.214285714285714 1.3 1 3 INOSITOL PHOSPHATE METABOLISM%KEGG%HSA00562 INOSITOL PHOSPHATE METABOLISM 0.0184850363466126 0.0658716768189426 1.71343334469826 0.214285714285714 1.3 1 3 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE 0.0833527793404582 0.207359697283763 1.71343334469826 0.214285714285714 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0833527793404582 0.207359697283763 1.71343334469826 0.214285714285714 1.3 1 3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION 0.0152259492334205 0.0565504621528588 1.70407032095674 0.213114754098361 1.3 1 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000179187859948579 0.00184577494798595 1.70237893602279 0.212903225806452 1.3 1 3 TYPE II DIABETES MELLITUS%KEGG%HSA04930 TYPE II DIABETES MELLITUS 0.0314207799960546 0.0989923498800429 1.70128133516139 0.212765957446809 1.3 1 3 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS CASPASE CASCADE IN APOPTOSIS 0.0314207799960546 0.0989923498800429 1.70128133516139 0.212765957446809 1.3 1 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.0314207799960546 0.0989923498800429 1.70128133516139 0.212765957446809 1.3 1 3 SNARE INTERACTIONS IN VESICULAR TRANSPORT%KEGG%HSA04130 SNARE INTERACTIONS IN VESICULAR TRANSPORT 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 PRION DISEASES%KEGG%HSA05020 PRION DISEASES 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_RECEPTOR_II_SIGNALING 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0670436765759927 0.174870598546877 1.69612593717606 0.212121212121212 1.3 1 3 CELL CYCLE%KEGG%HSA04110 CELL CYCLE 0.00110467038096298 0.00790913374871908 1.69407251594461 0.211864406779661 1.3 1 3 ECM-RECEPTOR INTERACTION%KEGG%HSA04512 ECM-RECEPTOR INTERACTION 0.0051725674235451 0.024576685217817 1.69327530534887 0.211764705882353 1.3 1 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.0021697882644368 0.0128714857055214 1.69146625053546 0.211538461538462 1.3 1 3 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY 8.7986580707228e-05 0.00101763426896912 1.69058756676895 0.211428571428571 1.3 1 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.0103709076280416 0.0424659680359406 1.68930048068843 0.211267605633803 1.3 1 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.00356438641811295 0.0188740702501282 1.68337311058075 0.210526315789474 1.3 1 3 VIRAL MYOCARDITIS%KEGG%HSA05416 VIRAL MYOCARDITIS 0.0211148182447819 0.0733012094434393 1.68337311058075 0.210526315789474 1.3 1 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0542119415507082 0.150218387655898 1.68337311058075 0.210526315789474 1.3 1 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0542119415507082 0.150218387655898 1.68337311058075 0.210526315789474 1.3 1 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00587679235630998 0.0271402827383352 1.67358605761226 0.209302325581395 1.3 1 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00587679235630998 0.0271402827383352 1.67358605761226 0.209302325581395 1.3 1 3 SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS 0.0440215426858809 0.127146558666668 1.67358605761226 0.209302325581395 1.3 1 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0440215426858809 0.127146558666668 1.67358605761226 0.209302325581395 1.3 1 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0440215426858809 0.127146558666668 1.67358605761226 0.209302325581395 1.3 1 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0142945761659161 0.0538012082267256 1.67081062468089 0.208955223880597 1.3 1 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.000217740117793754 0.00218319654228947 1.66788194698645 0.208588957055215 1.3 1 3 VIBRIO CHOLERAE INFECTION%KEGG%HSA05110 VIBRIO CHOLERAE INFECTION 0.035870183490412 0.107530085146833 1.6658379740122 0.208333333333333 1.3 1 3 GLYCOLYSIS%HUMANCYC%PWY66-400 GLYCOLYSIS 0.12035636523789 0.268057208726619 1.6658379740122 0.208333333333333 1.3 1 3 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY 0.12035636523789 0.268057208726619 1.6658379740122 0.208333333333333 1.3 1 3 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY 0.12035636523789 0.268057208726619 1.6658379740122 0.208333333333333 1.3 1 3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 DE NOVO PURINE BIOSYNTHESIS 0.12035636523789 0.268057208726619 1.6658379740122 0.208333333333333 1.3 1 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.93754005391574e-07 2.67400950226284e-05 1.66470088324495 0.208191126279863 1.3 1 3 RANKL%NETPATH%RANKL RANKL 0.0097328917644299 0.0406745413356603 1.66151112213165 0.207792207792208 1.3 1 3 NOD-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04621 NOD-LIKE RECEPTOR SIGNALING PATHWAY 0.0293123322396249 0.0940348176592347 1.65955179297819 0.207547169811321 1.3 1 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.59903482708758e-10 3.38951958536783e-08 1.65771193511458 0.207317073170732 1.3 1 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.17861773956504e-19 2.79400499307767e-16 1.65683344442294 0.207207207207207 1.3 1 3 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0.0240117744861625 0.0819419192796937 1.65434943626039 0.206896551724138 1.3 1 3 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 SIGNALING MEDIATED BY STAT4 0.0956817762103899 0.230212448783575 1.65434943626039 0.206896551724138 1.3 1 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 5.10052900658036e-15 1.68126187379405e-12 1.64834774176265 0.206145966709347 1.3 1 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.076681033811876 0.192030281255382 1.64623988020029 0.205882352941176 1.3 1 3 FC EPSILON RI SIGNALING PATHWAY%KEGG%HSA04664 FC EPSILON RI SIGNALING PATHWAY 0.0133514755039852 0.0510258563826218 1.64301827573806 0.205479452054795 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00261424032649568 0.0146532778951861 1.64204028866917 0.205357142857143 1.3 1 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0110127063000914 0.0443366511654061 1.64020969748893 0.205128205128205 1.3 1 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00622319039581754 0.0285898137173708 1.63359594870874 0.204301075268817 1.3 1 3 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS 0.0407383919332423 0.12084042691559 1.63184128066501 0.204081632653061 1.3 1 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.0407383919332423 0.12084042691559 1.63184128066501 0.204081632653061 1.3 1 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.28885183556984e-06 0.000178793447375165 1.62995838687963 0.203846153846154 1.3 1 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00354571956823003 0.018813003020971 1.62881935236748 0.203703703703704 1.3 1 3 GLIOMA%KEGG%HSA05214 GLIOMA 0.0271899336958866 0.0884091925475376 1.62630961530682 0.203389830508475 1.3 1 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0271899336958866 0.0884091925475376 1.62630961530682 0.203389830508475 1.3 1 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0271899336958866 0.0884091925475376 1.62630961530682 0.203389830508475 1.3 1 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.00017019655671563 0.0017600326276828 1.62486014149639 0.203208556149733 1.3 1 3 PANCREATIC CANCER%KEGG%HSA05212 PANCREATIC CANCER 0.0183145568919019 0.0657745049636777 1.62238133121188 0.202898550724638 1.3 1 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.95035398955395e-16 3.93368057840896e-13 1.61910405799919 0.202488687782805 1.3 1 3 ERBB SIGNALING PATHWAY%KEGG%HSA04012 ERBB SIGNALING PATHWAY 0.0102509408918095 0.0421055002051429 1.61824260332614 0.202380952380952 1.3 1 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.79414412254656e-10 7.48069614553396e-08 1.61136570566047 0.201520912547529 1.3 1 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0169575997740012 0.0619351670416081 1.59920445505171 0.2 1.3 1 3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0.108924520463525 0.253740247758228 1.59920445505171 0.2 1.3 1 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.108924520463525 0.253740247758228 1.59920445505171 0.2 1.3 1 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.108924520463525 0.253740247758228 1.59920445505171 0.2 1.3 1 3 ADIPOCYTOKINE SIGNALING PATHWAY%KEGG%HSA04920 ADIPOCYTOKINE SIGNALING PATHWAY 0.020620327246085 0.072020931056856 1.59920445505171 0.2 1.3 1 3 TRYPTOPHAN METABOLISM%KEGG%HSA00380 TRYPTOPHAN METABOLISM 0.0700801827495195 0.179244851513562 1.59920445505171 0.2 1.3 1 3 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP RECEPTOR SIGNALING 0.0700801827495195 0.179244851513562 1.59920445505171 0.2 1.3 1 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0700801827495195 0.179244851513562 1.59920445505171 0.2 1.3 1 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0700801827495195 0.179244851513562 1.59920445505171 0.2 1.3 1 3 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY PHOSPHOLIPASES 0.0870837978162172 0.215422115235802 1.59920445505171 0.2 1.3 1 3 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 INTERNALIZATION OF ERBB1 0.0870837978162172 0.215422115235802 1.59920445505171 0.2 1.3 1 3 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-MEDIATED SIGNALING EVENTS 0.0870837978162172 0.215422115235802 1.59920445505171 0.2 1.3 1 3 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III SIGNALING EVENTS MEDIATED BY HDAC CLASS III 0.137438372072013 0.296340954336793 1.59920445505171 0.2 1.3 1 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.137438372072013 0.296340954336793 1.59920445505171 0.2 1.3 1 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.137438372072013 0.296340954336793 1.59920445505171 0.2 1.3 1 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.137438372072013 0.296340954336793 1.59920445505171 0.2 1.3 1 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.24898095678241e-08 2.32092433563876e-06 1.59545045398351 0.199530516431925 1.3 1 3 HYPERTROPHIC CARDIOMYOPATHY (HCM)%KEGG%HSA05410 HYPERTROPHIC CARDIOMYOPATHY (HCM) 0.0156590688938201 0.0579957369002858 1.57946119017453 0.197530864197531 1.3 1 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.0156590688938201 0.0579957369002858 1.57946119017453 0.197530864197531 1.3 1 3 APOPTOSIS%KEGG%HSA04210 APOPTOSIS 0.0190191894301186 0.0675924562361492 1.57816229116945 0.197368421052632 1.3 1 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0190191894301186 0.0675924562361492 1.57816229116945 0.197368421052632 1.3 1 3 WNT SIGNALING PATHWAY%KEGG%HSA04310 WNT SIGNALING PATHWAY 0.00183488560978141 0.0117727332189625 1.57668044864253 0.197183098591549 1.3 1 3 LONG-TERM POTENTIATION%KEGG%HSA04720 LONG-TERM POTENTIATION 0.0344432565989575 0.104880909528234 1.57298798857545 0.19672131147541 1.3 1 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0344432565989575 0.104880909528234 1.57298798857545 0.19672131147541 1.3 1 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.00117965861382977 0.00836225743190622 1.5688398135001 0.19620253164557 1.3 1 3 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 WNT SIGNALING PATHWAY 8.13001623586969e-05 0.000961383534259568 1.56588769557147 0.195833333333333 1.3 1 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.00428400249989001 0.021352824104098 1.56019946834313 0.195121951219512 1.3 1 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.0175048211031496 0.0636692596538005 1.56019946834313 0.195121951219512 1.3 1 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0789715130226143 0.197391355299179 1.56019946834313 0.195121951219512 1.3 1 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0789715130226143 0.197391355299179 1.56019946834313 0.195121951219512 1.3 1 3 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F TRANSCRIPTION FACTOR NETWORK 0.0258773744064389 0.0855120755761647 1.55478210907805 0.194444444444444 1.3 1 3 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-841 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0982443862861583 0.231041513007844 1.55478210907805 0.194444444444444 1.3 1 3 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%HUMANCYC%PWY66-409 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE 0.0982443862861583 0.231041513007844 1.55478210907805 0.194444444444444 1.3 1 3 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY 0.0982443862861583 0.231041513007844 1.55478210907805 0.194444444444444 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0982443862861583 0.231041513007844 1.55478210907805 0.194444444444444 1.3 1 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0982443862861583 0.231041513007844 1.55478210907805 0.194444444444444 1.3 1 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.123050583186226 0.273595605279999 1.54761721456617 0.193548387096774 1.3 1 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0160843960126875 0.059487450610739 1.54468612135677 0.193181818181818 1.3 1 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0472082270285151 0.135944532562072 1.54309201803235 0.192982456140351 1.3 1 3 GLYCOSAMINOGLYCAN BIOSYNTHESIS - HEPARAN SULFATE%KEGG%HSA00534 GLYCOSAMINOGLYCAN BIOSYNTHESIS - HEPARAN SULFATE 0.155514903053142 0.327811989888997 1.53769659139588 0.192307692307692 1.3 1 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.155514903053142 0.327811989888997 1.53769659139588 0.192307692307692 1.3 1 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.155514903053142 0.327811989888997 1.53769659139588 0.192307692307692 1.3 1 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.155514903053142 0.327811989888997 1.53769659139588 0.192307692307692 1.3 1 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0351731383879514 0.106610995320722 1.52865131732884 0.191176470588235 1.3 1 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0885026518210486 0.218317579842942 1.52305186195401 0.19047619047619 1.3 1 3 LONG-TERM DEPRESSION%KEGG%HSA04730 LONG-TERM DEPRESSION 0.0429746319549827 0.125220004934021 1.52305186195401 0.19047619047619 1.3 1 3 OOCYTE MEIOSIS%KEGG%HSA04114 OOCYTE MEIOSIS 0.0135311407451337 0.0516376528870006 1.51924423229912 0.19 1.3 1 3 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 ALZHEIMER DISEASE-PRESENILIN PATHWAY 0.0163718192661876 0.0602967701186266 1.51503579952267 0.189473684210526 1.3 1 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.110149540927394 0.254140100421924 1.51276097099486 0.189189189189189 1.3 1 3 DILATED CARDIOMYOPATHY%KEGG%HSA05414 DILATED CARDIOMYOPATHY 0.0240512118022309 0.0819419192796937 1.50513360475455 0.188235294117647 1.3 1 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.0240512118022309 0.0819419192796937 1.50513360475455 0.188235294117647 1.3 1 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.0240512118022309 0.0819419192796937 1.50513360475455 0.188235294117647 1.3 1 3 CHEMOKINE SIGNALING PATHWAY%KEGG%HSA04062 CHEMOKINE SIGNALING PATHWAY 0.00241061659002038 0.013970980105239 1.50228297292736 0.187878787878788 1.3 1 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000110600007524291 0.00124210091836747 1.50105833326153 0.187725631768953 1.3 1 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0477472207457514 0.136680588952258 1.49925417661098 0.1875 1.3 1 3 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS SYNDECAN-4-MEDIATED SIGNALING EVENTS 0.138022236680589 0.297113990307521 1.49925417661098 0.1875 1.3 1 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.138022236680589 0.297113990307521 1.49925417661098 0.1875 1.3 1 3 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK P73 TRANSCRIPTION FACTOR NETWORK 0.0355316610649038 0.107450676867146 1.49259082471493 0.186666666666667 1.3 1 3 JAK-STAT SIGNALING PATHWAY%KEGG%HSA04630 JAK-STAT SIGNALING PATHWAY 0.00655760753136193 0.0300215469795163 1.49179520060794 0.186567164179104 1.3 1 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.00203405569291677 0.0122461298224236 1.49078381403126 0.186440677966102 1.3 1 3 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-MEDIATED SIGNALING EVENTS 0.0584688455360309 0.161278604266228 1.49078381403126 0.186440677966102 1.3 1 3 VASCULAR SMOOTH MUSCLE CONTRACTION%KEGG%HSA04270 VASCULAR SMOOTH MUSCLE CONTRACTION 0.0165425452519959 0.0605870719854349 1.48945512970502 0.186274509803922 1.3 1 3 INSULIN SIGNALING PATHWAY%KEGG%HSA04910 INSULIN SIGNALING PATHWAY 0.00788800648053392 0.0338773177348012 1.48763205121089 0.186046511627907 1.3 1 3 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION%KEGG%HSA00280 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION 0.0986697624805157 0.231693823384791 1.48763205121089 0.186046511627907 1.3 1 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00949362834965784 0.0397376158064249 1.48313316395925 0.185483870967742 1.3 1 3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-PHOSPHOINOSITIDE BIOSYNTHESIS 0.174504670241885 0.358946033875079 1.48074486578862 0.185185185185185 1.3 1 3 RNA POLYMERASE%KEGG%HSA03020 RNA POLYMERASE 0.174504670241885 0.358946033875079 1.48074486578862 0.185185185185185 1.3 1 3 PENTOSE PHOSPHATE PATHWAY%KEGG%HSA00030 PENTOSE PHOSPHATE PATHWAY 0.174504670241885 0.358946033875079 1.48074486578862 0.185185185185185 1.3 1 3 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY 0.174504670241885 0.358946033875079 1.48074486578862 0.185185185185185 1.3 1 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.174504670241885 0.358946033875079 1.48074486578862 0.185185185185185 1.3 1 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.174504670241885 0.358946033875079 1.48074486578862 0.185185185185185 1.3 1 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.00205069964870465 0.0123182117850436 1.47752585521082 0.184782608695652 1.3 1 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00419668509994898 0.0212004954187078 1.47697226740445 0.184713375796178 1.3 1 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000596639339922302 0.00482618999808316 1.47566076324514 0.184549356223176 1.3 1 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00660353682434115 0.0301794221937394 1.47444382380654 0.184397163120567 1.3 1 3 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS SYNDECAN-1-MEDIATED SIGNALING EVENTS 0.122780611754388 0.273225715777486 1.47295147175815 0.184210526315789 1.3 1 3 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK 0.0647110184196132 0.170302350870778 1.46593741713073 0.183333333333333 1.3 1 3 TGF-BETA SIGNALING PATHWAY%KEGG%HSA04350 TGF-BETA SIGNALING PATHWAY 0.0356001194962158 0.107530085146833 1.46268700157169 0.182926829268293 1.3 1 3 PYRIMIDINE METABOLISM%KEGG%HSA00240 PYRIMIDINE METABOLISM 0.0266574117751473 0.0869994985780487 1.46163848042361 0.182795698924731 1.3 1 3 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB TRANSCRIPTION FACTOR NETWORK 0.0432590413238637 0.125909593787007 1.45382223186519 0.181818181818182 1.3 1 3 RNA TRANSPORT%KEGG%HSA03013 RNA TRANSPORT 0.0104564545954048 0.0427265950926745 1.45382223186519 0.181818181818182 1.3 1 3 BASAL CELL CARCINOMA%KEGG%HSA05217 BASAL CELL CARCINOMA 0.0794208036814877 0.198326381920533 1.45382223186519 0.181818181818182 1.3 1 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.153795250037166 0.325227004288699 1.45382223186519 0.181818181818182 1.3 1 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.153795250037166 0.325227004288699 1.45382223186519 0.181818181818182 1.3 1 3 LEISHMANIASIS%KEGG%HSA05140 LEISHMANIASIS 0.0713699260201574 0.182190217730063 1.44190565619416 0.180327868852459 1.3 1 3 TRAIL%IOB%TRAIL TRAIL 0.0977904847365182 0.231041513007844 1.43928400954654 0.18 1.3 1 3 GNRH SIGNALING PATHWAY%KEGG%HSA04912 GNRH SIGNALING PATHWAY 0.0354419478514951 0.107302429947638 1.43748715060828 0.179775280898876 1.3 1 3 BLADDER CANCER%KEGG%HSA05219 BLADDER CANCER 0.136113900563858 0.296074737977236 1.43518348530282 0.179487179487179 1.3 1 3 ALDOSTERONE-REGULATED SODIUM REABSORPTION%KEGG%HSA04960 ALDOSTERONE-REGULATED SODIUM REABSORPTION 0.136113900563858 0.296074737977236 1.43518348530282 0.179487179487179 1.3 1 3 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 TRANSCRIPTION FACTOR NETWORK 0.136113900563858 0.296074737977236 1.43518348530282 0.179487179487179 1.3 1 3 CHOLINERGIC SYNAPSE%KEGG%HSA04725 CHOLINERGIC SYNAPSE 0.0241087267879146 0.0820318871480397 1.43324927575389 0.179245283018868 1.3 1 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0642012503572381 0.169298697192037 1.43212339258362 0.17910447761194 1.3 1 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0642012503572381 0.169298697192037 1.43212339258362 0.17910447761194 1.3 1 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.80622830547233e-07 6.26713689675072e-06 1.43008174440861 0.178849144634526 1.3 1 3 INFLUENZA A%KEGG%HSA05164 INFLUENZA A 0.0113931286504131 0.0457982930657614 1.42786112058188 0.178571428571429 1.3 1 3 HISTIDINE METABOLISM%KEGG%HSA00340 HISTIDINE METABOLISM 0.194320298698717 0.391461136492373 1.42786112058188 0.178571428571429 1.3 1 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000209375940061739 0.00211541898062377 1.42260519007668 0.177914110429448 1.3 1 3 METABOLIC PATHWAYS%KEGG%HSA01100 METABOLIC PATHWAYS 1.1827150207439e-10 1.29950812904236e-08 1.41196554572704 0.17658349328215 1.3 1 3 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) SIGNALING PATHWAY 0.170319724942586 0.352814701236134 1.41106275445739 0.176470588235294 1.3 1 3 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS SYNDECAN-2-MEDIATED SIGNALING EVENTS 0.170319724942586 0.352814701236134 1.41106275445739 0.176470588235294 1.3 1 3 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT 0.170319724942586 0.352814701236134 1.41106275445739 0.176470588235294 1.3 1 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.170319724942586 0.352814701236134 1.41106275445739 0.176470588235294 1.3 1 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.170319724942586 0.352814701236134 1.41106275445739 0.176470588235294 1.3 1 3 GLYCOLYSIS / GLUCONEOGENESIS%KEGG%HSA00010 GLYCOLYSIS / GLUCONEOGENESIS 0.0960948226078394 0.230995485156675 1.40281092548396 0.175438596491228 1.3 1 3 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 TRANSCRIPTION FACTOR NETWORK 0.150121052827506 0.319507034952488 1.39930389817025 0.175 1.3 1 3 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR 0.150121052827506 0.319507034952488 1.39930389817025 0.175 1.3 1 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.150121052827506 0.319507034952488 1.39930389817025 0.175 1.3 1 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0859545864880214 0.213228828380915 1.39613087345784 0.174603174603175 1.3 1 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.0121454196270683 0.0477309561200881 1.39285549310955 0.174193548387097 1.3 1 3 GLYCEROLIPID METABOLISM%KEGG%HSA00561 GLYCEROLIPID METABOLISM 0.132889703318421 0.293492585972091 1.39061256961018 0.173913043478261 1.3 1 3 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS 0.132889703318421 0.293492585972091 1.39061256961018 0.173913043478261 1.3 1 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.132889703318421 0.293492585972091 1.39061256961018 0.173913043478261 1.3 1 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0256666806709004 0.0855120755761647 1.38773940314405 0.173553719008264 1.3 1 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.0417337996051354 0.123187488657827 1.38706508856526 0.173469387755102 1.3 1 3 PANCREATIC SECRETION%KEGG%HSA04972 PANCREATIC SECRETION 0.0558757803414409 0.154449090943794 1.37862453021699 0.172413793103448 1.3 1 3 PROPANOATE METABOLISM%KEGG%HSA00640 PROPANOATE METABOLISM 0.214869990883785 0.411483054437575 1.37862453021699 0.172413793103448 1.3 1 3 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY 0.214869990883785 0.411483054437575 1.37862453021699 0.172413793103448 1.3 1 3 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY 0.214869990883785 0.411483054437575 1.37862453021699 0.172413793103448 1.3 1 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.214869990883785 0.411483054437575 1.37862453021699 0.172413793103448 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.214869990883785 0.411483054437575 1.37862453021699 0.172413793103448 1.3 1 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.214869990883785 0.411483054437575 1.37862453021699 0.172413793103448 1.3 1 3 PPAR SIGNALING PATHWAY%KEGG%HSA03320 PPAR SIGNALING PATHWAY 0.0839949143644411 0.208563643294756 1.37074667575861 0.171428571428571 1.3 1 3 GLYCEROPHOSPHOLIPID METABOLISM%KEGG%HSA00564 GLYCEROPHOSPHOLIPID METABOLISM 0.0752767680772876 0.191053741501258 1.36774065234686 0.171052631578947 1.3 1 3 ABC TRANSPORTERS%KEGG%HSA02010 ABC TRANSPORTERS 0.164769487493219 0.34566200359556 1.36517453480024 0.170731707317073 1.3 1 3 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 KINASE PATHWAY 0.164769487493219 0.34566200359556 1.36517453480024 0.170731707317073 1.3 1 3 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 INTERLEUKIN SIGNALING PATHWAY 0.0607231686760736 0.165079377112171 1.36295834237362 0.170454545454545 1.3 1 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0546382083080655 0.151186731698183 1.36102506812912 0.170212765957447 1.3 1 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.145484948475002 0.310894496862707 1.36102506812912 0.170212765957447 1.3 1 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0492144582115907 0.140149596440567 1.35932378679395 0.17 1.3 1 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0492144582115907 0.140149596440567 1.35932378679395 0.17 1.3 1 3 PURINE METABOLISM%KEGG%HSA00230 PURINE METABOLISM 0.0183976553655759 0.0657745049636777 1.35880117095897 0.169934640522876 1.3 1 3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY 0.114674956863473 0.25663368433909 1.35525801275569 0.169491525423729 1.3 1 3 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING P75(NTR)-MEDIATED SIGNALING 0.102239094170421 0.239861647088434 1.35317300042837 0.169230769230769 1.3 1 3 RHEUMATOID ARTHRITIS%KEGG%HSA05323 RHEUMATOID ARTHRITIS 0.0817803688240768 0.203832544980237 1.34997778673196 0.168831168831169 1.3 1 3 CALCIUM SIGNALING PATHWAY%KEGG%HSA04020 CALCIUM SIGNALING PATHWAY 0.016331525193539 0.06023249221729 1.34872664883879 0.168674698795181 1.3 1 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0036327273850866 0.0190520896886383 1.34834885425929 0.168627450980392 1.3 1 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0131478079548408 0.0503935604315628 1.33987400288116 0.167567567567568 1.3 1 3 CYTOSOLIC DNA-SENSING PATHWAY%KEGG%HSA04623 CYTOSOLIC DNA-SENSING PATHWAY 0.158640467702153 0.334133317356691 1.33267037920976 0.166666666666667 1.3 1 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.180022854627653 0.364049285010062 1.33267037920976 0.166666666666667 1.3 1 3 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY 0.20540026423628 0.404147764466771 1.33267037920976 0.166666666666667 1.3 1 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.20540026423628 0.404147764466771 1.33267037920976 0.166666666666667 1.3 1 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00495265604317903 0.0237889872237944 1.33267037920976 0.166666666666667 1.3 1 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00495265604317903 0.0237889872237944 1.33267037920976 0.166666666666667 1.3 1 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00495265604317903 0.0237889872237944 1.33267037920976 0.166666666666667 1.3 1 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.037048868059876 0.11014415453652 1.32265030117059 0.165413533834586 1.3 1 3 CELL ADHESION MOLECULES (CAMS)%KEGG%HSA04514 CELL ADHESION MOLECULES (CAMS) 0.0542312874662173 0.150218387655898 1.30969330370614 0.163793103448276 1.3 1 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0602066958400455 0.163844227998142 1.30844000867867 0.163636363636364 1.3 1 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.152321289253669 0.323667397068434 1.30844000867867 0.163636363636364 1.3 1 3 MTOR SIGNALING PATHWAY%KEGG%HSA04150 MTOR SIGNALING PATHWAY 0.172331218779529 0.356142181756754 1.30547302453201 0.163265306122449 1.3 1 3 PNAT%PANTHER PATHWAY%P05912 PNAT 0.172331218779529 0.356142181756754 1.30547302453201 0.163265306122449 1.3 1 3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 TOLL RECEPTOR SIGNALING PATHWAY 0.195841511434041 0.393623525649059 1.30167804480953 0.162790697674419 1.3 1 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.195841511434041 0.393623525649059 1.30167804480953 0.162790697674419 1.3 1 3 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 CADHERIN SIGNALING PATHWAY 0.0647064498134499 0.170302350870778 1.29665226085274 0.162162162162162 1.3 1 3 PYRUVATE METABOLISM%KEGG%HSA00620 PYRUVATE METABOLISM 0.223835888102516 0.420709363454266 1.29665226085274 0.162162162162162 1.3 1 3 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-MEDIATED SIGNALING EVENTS 0.223835888102516 0.420709363454266 1.29665226085274 0.162162162162162 1.3 1 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.9849027460332e-10 3.62351329009984e-08 1.29567565596507 0.162040025823112 1.3 1 3 BASE EXCISION REPAIR%KEGG%HSA03410 BASE EXCISION REPAIR 0.257791489156608 0.474198075074642 1.28968101213848 0.161290322580645 1.3 1 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.257791489156608 0.474198075074642 1.28968101213848 0.161290322580645 1.3 1 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.257791489156608 0.474198075074642 1.28968101213848 0.161290322580645 1.3 1 3 GLUTAMATERGIC SYNAPSE%KEGG%HSA04724 GLUTAMATERGIC SYNAPSE 0.0694302244075403 0.178274101034746 1.2850750085237 0.160714285714286 1.3 1 3 SPLICEOSOME%KEGG%HSA03040 SPLICEOSOME 0.0694302244075403 0.178274101034746 1.2850750085237 0.160714285714286 1.3 1 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.186529453835341 0.376629532744099 1.27936356404137 0.16 1.3 1 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.139835143011948 0.300771021307103 1.27472818880933 0.159420289855072 1.3 1 3 TOLL-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04620 TOLL-LIKE RECEPTOR SIGNALING PATHWAY 0.1068756869206 0.2496290402211 1.27209445288204 0.159090909090909 1.3 1 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.212183007897923 0.408115676022482 1.27209445288204 0.159090909090909 1.3 1 3 PROGESTERONE-MEDIATED OOCYTE MATURATION%KEGG%HSA04914 PROGESTERONE-MEDIATED OOCYTE MATURATION 0.119485930751936 0.267020677451573 1.26766206802879 0.158536585365854 1.3 1 3 MEASLES%KEGG%HSA05162 MEASLES 0.0795619561282181 0.198490897171345 1.26252983293556 0.157894736842105 1.3 1 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.133838587198682 0.295340882379017 1.26252983293556 0.157894736842105 1.3 1 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 0.000426424808693583 0.00368682695254092 1.26031874741378 0.157618213660245 1.3 1 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0689506385367233 0.177500570394053 1.25921610633993 0.15748031496063 1.3 1 3 ARGININE AND PROLINE METABOLISM%KEGG%HSA00330 ARGININE AND PROLINE METABOLISM 0.201205011262438 0.398630814950451 1.25427800396213 0.156862745098039 1.3 1 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.128057659269572 0.284249198227157 1.25238903106459 0.156626506024096 1.3 1 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.0346870943213046 0.105501577537809 1.24937848050915 0.15625 1.3 1 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.279970980355871 0.501892233309607 1.24937848050915 0.15625 1.3 1 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.229002574114816 0.427374230672872 1.24382568726244 0.155555555555556 1.3 1 3 FATTY ACID METABOLISM%KEGG%HSA00071 FATTY ACID METABOLISM 0.262178270936687 0.474198075074642 1.2301572731167 0.153846153846154 1.3 1 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.262178270936687 0.474198075074642 1.2301572731167 0.153846153846154 1.3 1 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.262178270936687 0.474198075074642 1.2301572731167 0.153846153846154 1.3 1 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.1462036102227 0.311924692683868 1.22292105386307 0.152941176470588 1.3 1 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.1462036102227 0.311924692683868 1.22292105386307 0.152941176470588 1.3 1 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.172214310660481 0.356142181756754 1.22161451427561 0.152777777777778 1.3 1 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0638466596463755 0.168701043574641 1.21890583464307 0.152439024390244 1.3 1 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.246253602206476 0.45794834204406 1.21678599840891 0.152173913043478 1.3 1 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.0939853279531013 0.226544158877814 1.21151852655433 0.151515151515152 1.3 1 3 GASTRIC ACID SECRETION%KEGG%HSA04971 GASTRIC ACID SECRETION 0.193800736705154 0.39071295312805 1.21151852655433 0.151515151515152 1.3 1 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.193800736705154 0.39071295312805 1.21151852655433 0.151515151515152 1.3 1 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.302502360769925 0.519809821504182 1.21151852655433 0.151515151515152 1.3 1 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.231857193119808 0.432090048238116 1.20694675852959 0.150943396226415 1.3 1 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.231857193119808 0.432090048238116 1.20694675852959 0.150943396226415 1.3 1 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0952707368082372 0.229432815491618 1.19940334128878 0.15 1.3 1 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.218739385980492 0.416506449437272 1.19940334128878 0.15 1.3 1 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.218739385980492 0.416506449437272 1.19940334128878 0.15 1.3 1 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.281953074132424 0.504416727603259 1.19940334128878 0.15 1.3 1 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0834599254640494 0.207430559329593 1.19195363109444 0.149068322981366 1.3 1 3 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FOXO FAMILY SIGNALING 0.263888116609484 0.474198075074642 1.19089693461298 0.148936170212766 1.3 1 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0921178153892864 0.223884496941519 1.1865065311674 0.148387096774194 1.3 1 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.247764162551546 0.459137512717978 1.1845958926309 0.148148148148148 1.3 1 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.08810777412969 0.217547004101117 1.1845958926309 0.148148148148148 1.3 1 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0707776021745586 0.18085323346348 1.17707942123095 0.147208121827411 1.3 1 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.325292470395329 0.547063931398266 1.17588562871449 0.147058823529412 1.3 1 3 AMINOACYL-TRNA BIOSYNTHESIS%KEGG%HSA00970 AMINOACYL-TRNA BIOSYNTHESIS 0.30204168898486 0.519809821504182 1.17014960125735 0.146341463414634 1.3 1 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.30204168898486 0.519809821504182 1.17014960125735 0.146341463414634 1.3 1 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.30204168898486 0.519809821504182 1.17014960125735 0.146341463414634 1.3 1 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.124212903965032 0.275947285388196 1.16730252193556 0.145985401459854 1.3 1 3 AMYOTROPHIC LATERAL SCLEROSIS (ALS)%KEGG%HSA05014 AMYOTROPHIC LATERAL SCLEROSIS (ALS) 0.281857227398541 0.504416727603259 1.16608658180854 0.145833333333333 1.3 1 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.281857227398541 0.504416727603259 1.16608658180854 0.145833333333333 1.3 1 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.159418185387229 0.335503395743114 1.16305778549215 0.145454545454545 1.3 1 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.233549762498629 0.434630009674583 1.15884380800849 0.144927536231884 1.3 1 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.233549762498629 0.434630009674583 1.15884380800849 0.144927536231884 1.3 1 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.113544668929358 0.25663368433909 1.15665731025753 0.144654088050314 1.3 1 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.113544668929358 0.25663368433909 1.15665731025753 0.144654088050314 1.3 1 3 CYTOKINE-CYTOKINE RECEPTOR INTERACTION%KEGG%HSA04060 CYTOKINE-CYTOKINE RECEPTOR INTERACTION 0.075625061676243 0.191181542509069 1.15257978742466 0.144144144144144 1.3 1 3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY 0.159842613215229 0.335860534700048 1.15196931084233 0.144067796610169 1.3 1 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.300111562168376 0.517589397931986 1.14228889646551 0.142857142857143 1.3 1 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.300111562168376 0.517589397931986 1.14228889646551 0.142857142857143 1.3 1 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.322378161377728 0.543986020975255 1.14228889646551 0.142857142857143 1.3 1 3 PROTEIN DIGESTION AND ABSORPTION%KEGG%HSA04974 PROTEIN DIGESTION AND ABSORPTION 0.247433717398605 0.459137512717978 1.14228889646551 0.142857142857143 1.3 1 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.247433717398605 0.459137512717978 1.14228889646551 0.142857142857143 1.3 1 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.247433717398605 0.459137512717978 1.14228889646551 0.142857142857143 1.3 1 3 COMPLEMENT AND COAGULATION CASCADES%KEGG%HSA04610 COMPLEMENT AND COAGULATION CASCADES 0.263130979181409 0.474198075074642 1.14228889646551 0.142857142857143 1.3 1 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.263130979181409 0.474198075074642 1.14228889646551 0.142857142857143 1.3 1 3 OTHER TYPES OF O-GLYCAN BIOSYNTHESIS%KEGG%HSA00514 OTHER TYPES OF O-GLYCAN BIOSYNTHESIS 0.348251056920452 0.578828032135397 1.14228889646551 0.142857142857143 1.3 1 3 CYSTEINE AND METHIONINE METABOLISM%KEGG%HSA00270 CYSTEINE AND METHIONINE METABOLISM 0.348251056920452 0.578828032135397 1.14228889646551 0.142857142857143 1.3 1 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.348251056920452 0.578828032135397 1.14228889646551 0.142857142857143 1.3 1 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.0211023884999409 0.0733012094434393 1.13075062478404 0.141414141414141 1.3 1 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.159610752846214 0.335640793664645 1.12620032045895 0.140845070422535 1.3 1 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.144334517028041 0.308686229848292 1.12139336787163 0.140243902439024 1.3 1 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.206796944127528 0.404147764466771 1.12093770213905 0.14018691588785 1.3 1 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.318601672827242 0.53821435697978 1.1194431185362 0.14 1.3 1 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.175954925838889 0.360229882007704 1.11709134727877 0.139705882352941 1.3 1 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.143899163489026 0.30800494652643 1.11572403840817 0.13953488372093 1.3 1 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.342897618125353 0.574108583489876 1.11572403840817 0.13953488372093 1.3 1 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.195107333728707 0.392746594689008 1.11419982524095 0.139344262295082 1.3 1 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.371291507353383 0.597068807660841 1.11055864934147 0.138888888888889 1.3 1 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.184286268344002 0.372385356033052 1.10893739583878 0.138686131386861 1.3 1 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.257340268864745 0.474198075074642 1.10289962417359 0.137931034482759 1.3 1 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.257340268864745 0.474198075074642 1.10289962417359 0.137931034482759 1.3 1 3 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS 0.363536767108631 0.595062976328653 1.09036667389889 0.136363636363636 1.3 1 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.363536767108631 0.595062976328653 1.09036667389889 0.136363636363636 1.3 1 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.363536767108631 0.595062976328653 1.09036667389889 0.136363636363636 1.3 1 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.28701169688097 0.512077026167198 1.08587956824499 0.135802469135802 1.3 1 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.28701169688097 0.512077026167198 1.08587956824499 0.135802469135802 1.3 1 3 P53 SIGNALING PATHWAY%KEGG%HSA04115 P53 SIGNALING PATHWAY 0.331617855962145 0.556282624791462 1.08420641020455 0.135593220338983 1.3 1 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.331617855962145 0.556282624791462 1.08420641020455 0.135593220338983 1.3 1 3 TUBERCULOSIS%KEGG%HSA05152 TUBERCULOSIS 0.2085129531224 0.404147764466771 1.08054355071062 0.135135135135135 1.3 1 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.305506887391624 0.519809821504182 1.08054355071062 0.135135135135135 1.3 1 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.305506887391624 0.519809821504182 1.08054355071062 0.135135135135135 1.3 1 3 TYROSINE METABOLISM%KEGG%HSA00350 TYROSINE METABOLISM 0.39433144786133 0.610958888372695 1.08054355071062 0.135135135135135 1.3 1 3 FRUCTOSE AND MANNOSE METABOLISM%KEGG%HSA00051 FRUCTOSE AND MANNOSE METABOLISM 0.39433144786133 0.610958888372695 1.08054355071062 0.135135135135135 1.3 1 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.196457416577084 0.3939813741056 1.07921773040299 0.134969325153374 1.3 1 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.151452494278466 0.322080828558318 1.06613630336781 0.133333333333333 1.3 1 3 GLUTATHIONE METABOLISM%KEGG%HSA00480 GLUTATHIONE METABOLISM 0.384234335261527 0.606859130265946 1.06613630336781 0.133333333333333 1.3 1 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.384234335261527 0.606859130265946 1.06613630336781 0.133333333333333 1.3 1 3 HEDGEHOG SIGNALING PATHWAY%KEGG%HSA04340 HEDGEHOG SIGNALING PATHWAY 0.374998787599725 0.597068807660841 1.05607841371339 0.132075471698113 1.3 1 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.335712008292062 0.562792476710851 1.05210819411297 0.131578947368421 1.3 1 3 TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY TRNA CHARGING 0.41729321989823 0.643886612563858 1.05210819411297 0.131578947368421 1.3 1 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.41729321989823 0.643886612563858 1.05210819411297 0.131578947368421 1.3 1 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.304911911710817 0.519809821504182 1.04998272301375 0.131313131313131 1.3 1 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.366458718977974 0.597068807660841 1.0486586590503 0.131147540983607 1.3 1 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.366458718977974 0.597068807660841 1.0486586590503 0.131147540983607 1.3 1 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.366458718977974 0.597068807660841 1.0486586590503 0.131147540983607 1.3 1 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.366458718977974 0.597068807660841 1.0486586590503 0.131147540983607 1.3 1 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.299993155510943 0.517589397931986 1.04620852199645 0.130841121495327 1.3 1 3 STARCH AND SUCROSE METABOLISM%KEGG%HSA00500 STARCH AND SUCROSE METABOLISM 0.404931445219784 0.625911032265281 1.04295942720764 0.130434782608696 1.3 1 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.404931445219784 0.625911032265281 1.04295942720764 0.130434782608696 1.3 1 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.317834129179368 0.53726192220897 1.03948289578361 0.13 1.3 1 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.286051981633263 0.511056284259428 1.03765174564424 0.129770992366412 1.3 1 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.286051981633263 0.511056284259428 1.03765174564424 0.129770992366412 1.3 1 3 P53 PATHWAY%PANTHER PATHWAY%P00059 P53 PATHWAY 0.393948625372859 0.610958888372695 1.03652140605203 0.12962962962963 1.3 1 3 SALIVARY SECRETION%KEGG%HSA04970 SALIVARY SECRETION 0.374880270227798 0.597068807660841 1.02806000681896 0.128571428571429 1.3 1 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.440104241804339 0.66635109619611 1.02513106093058 0.128205128205128 1.3 1 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.440104241804339 0.66635109619611 1.02513106093058 0.128205128205128 1.3 1 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.412898043530453 0.637851283415234 1.01767556230563 0.127272727272727 1.3 1 3 BILE SECRETION%KEGG%HSA04976 BILE SECRETION 0.401587039782239 0.621470084451739 1.01536790796934 0.126984126984127 1.3 1 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.401587039782239 0.621470084451739 1.01536790796934 0.126984126984127 1.3 1 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0119325292921564 0.0472463659811058 1.01412965442304 0.126829268292683 1.3 1 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.381898843153153 0.604119525731772 1.01215471838716 0.126582278481013 1.3 1 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.381898843153153 0.604119525731772 1.01215471838716 0.126582278481013 1.3 1 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.343189974275009 0.574233478529948 1.00790196746957 0.126050420168067 1.3 1 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.336641610042424 0.563992328895726 1.00737288507194 0.125984251968504 1.3 1 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.419168372339136 0.645269701026446 0.999502784407319 0.125 1.3 1 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.44610260446705 0.666877873004315 0.999502784407319 0.125 1.3 1 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.44610260446705 0.666877873004315 0.999502784407319 0.125 1.3 1 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.4318040040409 0.658519688510145 0.999502784407319 0.125 1.3 1 3 RIBOSOME BIOGENESIS IN EUKARYOTES%KEGG%HSA03008 RIBOSOME BIOGENESIS IN EUKARYOTES 0.436714979846704 0.664522447695187 0.98412581849336 0.123076923076923 1.3 1 3 ANTIGEN PROCESSING AND PRESENTATION%KEGG%HSA04612 ANTIGEN PROCESSING AND PRESENTATION 0.466473447578493 0.692228745787556 0.979104768399006 0.122448979591837 1.3 1 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.466473447578493 0.692228745787556 0.979104768399006 0.122448979591837 1.3 1 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.428528486659859 0.658519688510145 0.975124667714458 0.121951219512195 1.3 1 3 DRUG METABOLISM - OTHER ENZYMES%KEGG%HSA00983 DRUG METABOLISM - OTHER ENZYMES 0.485010540309221 0.70975182841033 0.975124667714458 0.121951219512195 1.3 1 3 TASTE TRANSDUCTION%KEGG%HSA04742 TASTE TRANSDUCTION 0.485010540309221 0.70975182841033 0.975124667714458 0.121951219512195 1.3 1 3 PEROXISOME%KEGG%HSA04146 PEROXISOME 0.440714946434184 0.66635109619611 0.972489195639554 0.121621621621622 1.3 1 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.469323123921897 0.693187792775266 0.965037171151894 0.120689655172414 1.3 1 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.469323123921897 0.693187792775266 0.965037171151894 0.120689655172414 1.3 1 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.469323123921897 0.693187792775266 0.965037171151894 0.120689655172414 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.469323123921897 0.693187792775266 0.965037171151894 0.120689655172414 1.3 1 3 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY 0.486637780499118 0.711738118234151 0.959522673031026 0.12 1.3 1 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.471573377491916 0.693187792775266 0.954748928389081 0.119402985074627 1.3 1 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.459535237151766 0.682701081898145 0.951907413721256 0.119047619047619 1.3 1 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.459535237151766 0.682701081898145 0.951907413721256 0.119047619047619 1.3 1 3 FAT DIGESTION AND ABSORPTION%KEGG%HSA04975 FAT DIGESTION AND ABSORPTION 0.506987888813477 0.72472733117155 0.951907413721256 0.119047619047619 1.3 1 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.506987888813477 0.72472733117155 0.951907413721256 0.119047619047619 1.3 1 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.487860371531864 0.713130709384437 0.948680608928981 0.11864406779661 1.3 1 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.526177458551382 0.747994586630725 0.922617954837525 0.115384615384615 1.3 1 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.526177458551382 0.747994586630725 0.922617954837525 0.115384615384615 1.3 1 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.524317506424906 0.746155026682395 0.917576326669014 0.114754098360656 1.3 1 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.545476863353721 0.767568030236799 0.905210068897195 0.113207547169811 1.3 1 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.564417893101329 0.782940549241559 0.888446919473173 0.111111111111111 1.3 1 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.555987516341494 0.78069173620475 0.888446919473172 0.111111111111111 1.3 1 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.555987516341494 0.78069173620475 0.888446919473172 0.111111111111111 1.3 1 3 MALARIA%KEGG%HSA05144 MALARIA 0.570425888175973 0.790858605215585 0.888446919473172 0.111111111111111 1.3 1 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.572198813978956 0.792899775335001 0.876276413726965 0.10958904109589 1.3 1 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.582971344069191 0.800674705370029 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.582971344069191 0.800674705370029 0.872293339119115 0.109090909090909 1.3 1 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.582971344069191 0.800674705370029 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.582971344069191 0.800674705370029 0.872293339119115 0.109090909090909 1.3 1 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.582971344069191 0.800674705370029 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.582971344069191 0.800674705370029 0.872293339119115 0.109090909090909 1.3 1 3 HEMATOPOIETIC CELL LINEAGE%KEGG%HSA04640 HEMATOPOIETIC CELL LINEAGE 0.603781975998151 0.822587924967125 0.852909042694246 0.106666666666667 1.3 1 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.6210181282486 0.835949364058988 0.841686555290374 0.105263157894737 1.3 1 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.629342827845499 0.846291196852923 0.832918987006099 0.104166666666667 1.3 1 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.629342827845499 0.846291196852923 0.832918987006099 0.104166666666667 1.3 1 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.636064804548489 0.85489443914086 0.827174718130195 0.103448275862069 1.3 1 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.657991975253638 0.872799214659881 0.81119066560594 0.101449275362319 1.3 1 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.734952700065275 0.938987533949676 0.802813481451662 0.100401606425703 1.3 1 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.665763259907598 0.88133419496804 0.799602227525855 0.1 1.3 1 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.687610992753699 0.90194139347664 0.788340224321266 0.0985915492957746 1.3 1 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.687610992753699 0.90194139347664 0.788340224321266 0.0985915492957746 1.3 1 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.700229995588031 0.909609112495389 0.773808607283086 0.0967741935483871 1.3 1 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.715830452992919 0.928627846490933 0.754341724080996 0.0943396226415094 1.3 1 3 ARACHIDONIC ACID METABOLISM%KEGG%HSA00590 ARACHIDONIC ACID METABOLISM 0.746111651220062 0.951400592005466 0.726911115932596 0.0909090909090909 1.3 1 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.788858547492133 0.990109466795219 0.708508302871011 0.0886075949367089 1.3 1 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.788858547492133 0.990109466795219 0.708508302871011 0.0886075949367089 1.3 1 3 CARDIAC MUSCLE CONTRACTION%KEGG%HSA04260 CARDIAC MUSCLE CONTRACTION 0.833191633543236 1 0.644840506069238 0.0806451612903226 1.3 1 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.90341169992814 1 0.61507863655835 0.0769230769230769 1.3 1 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.959590587552631 1 0.601851138997956 0.0752688172043011 1.3 1 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.962937228872399 1 0.518260703026017 0.0648148148148148 1.3 1 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999982407 1 0.456531918318708 0.0570948782535684 1.3 1 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.995635446499509 1 0.454319447457872 0.0568181818181818 1.3 1 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99993401801823 1 0.453382706329093 0.0567010309278351 1.3 1 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.977090036044911 1 0.444223459736586 0.0555555555555556 1.3 1 3 NEUROACTIVE LIGAND-RECEPTOR INTERACTION%KEGG%HSA04080 NEUROACTIVE LIGAND-RECEPTOR INTERACTION 0.999511612528966 1 0.433892681603177 0.0542635658914729 1.3 1 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.986822825196971 1 0.412166096662812 0.0515463917525773 1.3 1 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999898052145136 1 0.399801113762928 0.05 1.3 1 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999999999 1 0.361483827995414 0.0452079566003617 1.3 1 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999998939740967 1 0.221088173509453 0.0276497695852535 1.3 1 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0021012421251205 0.00742758107767125 2.43117224638414 1 10.1 10 1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0021012421251205 0.00742758107767125 2.43117224638414 1 10.1 10 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000178339921825633 0.000946242200913874 2.43117224638414 1 10.1 10 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.000178339921825633 0.000946242200913874 2.43117224638414 1 10.1 10 1 &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 &GAMMA;-GLUTAMYL CYCLE 0.000612178268240242 0.0026377681263881 2.43117224638414 1 10.1 10 1 SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES 3.46215731367942e-07 4.45351650545007e-06 2.2690940966252 0.933333333333333 10.1 10 1 TNFSF3%IOB%TNFSF3 TNFSF3 3.5531775402813e-06 3.39793567505432e-05 2.24415899666228 0.923076923076923 10.1 10 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 3.5531775402813e-06 3.39793567505432e-05 2.24415899666228 0.923076923076923 10.1 10 1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY 1.12910893150714e-05 9.42017771387079e-05 2.22857455918546 0.916666666666667 10.1 10 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000346496696175257 0.00167346481284643 2.1610419967859 0.888888888888889 10.1 10 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.000346496696175257 0.00167346481284643 2.1610419967859 0.888888888888889 10.1 10 1 BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY 0.00106306725344279 0.00425251421676142 2.12727571558612 0.875 10.1 10 1 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 PATHWAY 0.00106306725344279 0.00425251421676142 2.12727571558612 0.875 10.1 10 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.00106306725344279 0.00425251421676142 2.12727571558612 0.875 10.1 10 1 SA_MMP_CYTOKINE_CONNECTION%MSIGDB_C2%SA_MMP_CYTOKINE_CONNECTION SA_MMP_CYTOKINE_CONNECTION 6.0884595070415e-06 5.55545595850118e-05 2.10701594686626 0.866666666666667 10.1 10 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00321520834672789 0.010614942618177 2.08386192547212 0.857142857142857 10.1 10 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00321520834672789 0.010614942618177 2.08386192547212 0.857142857142857 10.1 10 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.00321520834672789 0.010614942618177 2.08386192547212 0.857142857142857 10.1 10 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00321520834672789 0.010614942618177 2.08386192547212 0.857142857142857 10.1 10 1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES P38 SIGNALING MEDIATED BY MAPKAP KINASES 3.40313563996585e-07 4.42072348896057e-06 2.06649640942652 0.85 10.1 10 1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 PATHWAY 5.38496040764167e-05 0.000356787452134449 2.05714574694043 0.846153846153846 10.1 10 1 SA_PROGRAMMED_CELL_DEATH%MSIGDB_C2%SA_PROGRAMMED_CELL_DEATH SA_PROGRAMMED_CELL_DEATH 0.000157412821884348 0.000854110311335443 2.02597687198678 0.833333333333333 10.1 10 1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY 0.000157412821884348 0.000854110311335443 2.02597687198678 0.833333333333333 10.1 10 1 CYANOAMINO ACID METABOLISM%KEGG%HSA00460 CYANOAMINO ACID METABOLISM 0.00954656140952179 0.0248022487063142 2.02597687198678 0.833333333333333 10.1 10 1 VITAMIN B6 METABOLISM%KEGG%HSA00750 VITAMIN B6 METABOLISM 0.00954656140952179 0.0248022487063142 2.02597687198678 0.833333333333333 10.1 10 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00954656140952179 0.0248022487063142 2.02597687198678 0.833333333333333 10.1 10 1 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00954656140952179 0.0248022487063142 2.02597687198678 0.833333333333333 10.1 10 1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 OXIDATIVE STRESS RESPONSE 1.61125591393012e-07 2.26004353459241e-06 2.00835968179559 0.826086956521739 10.1 10 1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY 8.33951949434961e-06 7.21026652675407e-05 2.00214184996341 0.823529411764706 10.1 10 1 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY 0.000453697144141093 0.00206632015388612 1.98914092885975 0.818181818181818 10.1 10 1 TNFSF1%IOB%TNFSF1 TNFSF1 2.37257905885447e-05 0.000175744128601102 1.97532745018711 0.8125 10.1 10 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 2.37257905885447e-05 0.000175744128601102 1.97532745018711 0.8125 10.1 10 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.27668215910059e-08 1.10916825743054e-06 1.9636391220795 0.807692307692308 10.1 10 1 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY 0.0012858665023411 0.00497419817724688 1.94493779710731 0.8 10.1 10 1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY 0.0012858665023411 0.00497419817724688 1.94493779710731 0.8 10.1 10 1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY 0.0012858665023411 0.00497419817724688 1.94493779710731 0.8 10.1 10 1 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY 0.0012858665023411 0.00497419817724688 1.94493779710731 0.8 10.1 10 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0012858665023411 0.00497419817724688 1.94493779710731 0.8 10.1 10 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0012858665023411 0.00497419817724688 1.94493779710731 0.8 10.1 10 1 GLYCOSPHINGOLIPID BIOSYNTHESIS - GANGLIO SERIES%KEGG%HSA00604 GLYCOSPHINGOLIPID BIOSYNTHESIS - GANGLIO SERIES 6.66519288379468e-05 0.000422502731600158 1.94493779710731 0.8 10.1 10 1 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY 6.66519288379468e-05 0.000422502731600158 1.94493779710731 0.8 10.1 10 1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY 6.66519288379468e-05 0.000422502731600158 1.94493779710731 0.8 10.1 10 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 6.66519288379468e-05 0.000422502731600158 1.94493779710731 0.8 10.1 10 1 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY 5.60396613506758e-07 6.73751152383516e-06 1.92467802838744 0.791666666666667 10.1 10 1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-MEDIATED SIGNALING EVENTS 5.60396613506758e-07 6.73751152383516e-06 1.92467802838744 0.791666666666667 10.1 10 1 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 PATHWAY 1.00280169057014e-05 8.58567551309561e-05 1.91934651030327 0.789473684210526 10.1 10 1 BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY 1.53266140258747e-06 1.61021040582596e-05 1.90265654064846 0.782608695652174 10.1 10 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.36825780319322e-08 2.5283491575696e-07 1.89935331748761 0.78125 10.1 10 1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA 0.00357106420387918 0.01137306317105 1.89091174718767 0.777777777777778 10.1 10 1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 SALVAGE PYRIMIDINE RIBONUCLEOTIDES 0.00357106420387918 0.01137306317105 1.89091174718767 0.777777777777778 10.1 10 1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL SIGNALING EVENTS MEDIATED BY PRL 4.1461739133282e-06 3.83630196822683e-05 1.87863309947865 0.772727272727273 10.1 10 1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 SPECIFIC SIGNALS 6.36521311667933e-07 7.4933334770908e-06 1.87013249721857 0.769230769230769 10.1 10 1 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY ATYPICAL NF-KAPPAB PATHWAY 0.000502623547910784 0.00221641855491762 1.87013249721857 0.769230769230769 10.1 10 1 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 HYPOXIA RESPONSE VIA HIF ACTIVATION 0.000502623547910784 0.00221641855491762 1.87013249721857 0.769230769230769 10.1 10 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000502623547910784 0.00221641855491762 1.87013249721857 0.769230769230769 10.1 10 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 9.86911180135653e-08 1.48713416115298e-06 1.86389872222784 0.766666666666667 10.1 10 1 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY 7.37311716446789e-05 0.000457480234416513 1.85913171782317 0.764705882352941 10.1 10 1 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY 7.37311716446789e-05 0.000457480234416513 1.85913171782317 0.764705882352941 10.1 10 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 7.37311716446789e-05 0.000457480234416513 1.85913171782317 0.764705882352941 10.1 10 1 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY 1.10822682547197e-05 9.33672248808171e-05 1.85232171153077 0.761904761904762 10.1 10 1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY 1.10822682547197e-05 9.33672248808171e-05 1.85232171153077 0.761904761904762 10.1 10 1 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 PATHWAY 1.69258318618375e-06 1.75033014194767e-05 1.84769090725195 0.76 10.1 10 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.69258318618375e-06 1.75033014194767e-05 1.84769090725195 0.76 10.1 10 1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS OSTEOPONTIN-MEDIATED EVENTS 2.61434080473709e-07 3.53539318055985e-06 1.84433756622245 0.758620689655172 10.1 10 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 4.44945576982961e-06 4.08822817597236e-05 1.82337918478811 0.75 10.1 10 1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY 0.00134255011091133 0.00508664460125457 1.82337918478811 0.75 10.1 10 1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY 0.00134255011091133 0.00508664460125457 1.82337918478811 0.75 10.1 10 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00134255011091133 0.00508664460125457 1.82337918478811 0.75 10.1 10 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00134255011091133 0.00508664460125457 1.82337918478811 0.75 10.1 10 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00134255011091133 0.00508664460125457 1.82337918478811 0.75 10.1 10 1 SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY 0.000195430343586155 0.00101646906516112 1.82337918478811 0.75 10.1 10 1 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY 0.000195430343586155 0.00101646906516112 1.82337918478811 0.75 10.1 10 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00967163162658321 0.0250040123522548 1.82337918478811 0.75 10.1 10 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00967163162658321 0.0250040123522548 1.82337918478811 0.75 10.1 10 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00967163162658321 0.0250040123522548 1.82337918478811 0.75 10.1 10 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00967163162658321 0.0250040123522548 1.82337918478811 0.75 10.1 10 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00967163162658321 0.0250040123522548 1.82337918478811 0.75 10.1 10 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.77839939558681e-06 1.82476233702818e-05 1.80086833065492 0.740740740740741 10.1 10 1 TNFSF8%IOB%TNFSF8 TNFSF8 7.59735770585152e-05 0.000469185767455046 1.79139007628305 0.736842105263158 10.1 10 1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION 1.11002373074894e-07 1.64445650448593e-06 1.78762665175304 0.735294117647059 10.1 10 1 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY 0.000508809408151126 0.00223249652128872 1.78285964734837 0.733333333333333 10.1 10 1 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY 0.000508809408151126 0.00223249652128872 1.78285964734837 0.733333333333333 10.1 10 1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY 0.000508809408151126 0.00223249652128872 1.78285964734837 0.733333333333333 10.1 10 1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS 2.82227132953778e-07 3.73986406833725e-06 1.76812527009756 0.727272727272727 10.1 10 1 VALINE, LEUCINE AND ISOLEUCINE BIOSYNTHESIS%KEGG%HSA00290 VALINE, LEUCINE AND ISOLEUCINE BIOSYNTHESIS 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 ST_STAT3_PATHWAY%MSIGDB_C2%ST_STAT3_PATHWAY ST_STAT3_PATHWAY 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00350498479087446 0.0112116702855098 1.76812527009756 0.727272727272727 10.1 10 1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY%MSIGDB_C2%ST_TUMOR_NECROSIS_FACTOR_PATHWAY ST_TUMOR_NECROSIS_FACTOR_PATHWAY 1.79898475548011e-06 1.83872976751979e-05 1.76050404048507 0.724137931034483 10.1 10 1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM 0.000194238727545675 0.00101427232581771 1.75584662238855 0.722222222222222 10.1 10 1 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY 0.000194238727545675 0.00101427232581771 1.75584662238855 0.722222222222222 10.1 10 1 CD40%IOB%CD40 CD40 1.15385566992046e-05 9.42017771387079e-05 1.75044401739658 0.72 10.1 10 1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY P38 MAPK SIGNALING PATHWAY 1.15385566992046e-05 9.42017771387079e-05 1.75044401739658 0.72 10.1 10 1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM 1.15385566992046e-05 9.42017771387079e-05 1.75044401739658 0.72 10.1 10 1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- AND CXCR2-MEDIATED SIGNALING EVENTS 7.10080730023403e-07 8.21264423277068e-06 1.7474050520886 0.71875 10.1 10 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.4603177616198e-05 0.000461804176934071 1.7365516045601 0.714285714285714 10.1 10 1 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-MEDIATED SIGNALING EVENTS 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00129778094271743 0.00497419817724688 1.7365516045601 0.714285714285714 10.1 10 1 TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5651 TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE 0.0253749440665065 0.0568510853894458 1.7365516045601 0.714285714285714 10.1 10 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0253749440665065 0.0568510853894458 1.7365516045601 0.714285714285714 10.1 10 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0253749440665065 0.0568510853894458 1.7365516045601 0.714285714285714 10.1 10 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0253749440665065 0.0568510853894458 1.7365516045601 0.714285714285714 10.1 10 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0253749440665065 0.0568510853894458 1.7365516045601 0.714285714285714 10.1 10 1 IL3%NETPATH%IL3 IL3 8.21300045818359e-15 8.32987777239621e-13 1.7322102255487 0.7125 10.1 10 1 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY 1.76658961425212e-06 1.8197253174933e-05 1.725348045821 0.709677419354839 10.1 10 1 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY 2.87980395090204e-05 0.000205244405906181 1.72208034118877 0.708333333333333 10.1 10 1 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 PATHWAY 2.87980395090204e-05 0.000205244405906181 1.72208034118877 0.708333333333333 10.1 10 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.87980395090204e-05 0.000205244405906181 1.72208034118877 0.708333333333333 10.1 10 1 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY 0.000487508356245695 0.00219378760310563 1.71612158568292 0.705882352941177 10.1 10 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000487508356245695 0.00219378760310563 1.71612158568292 0.705882352941177 10.1 10 1 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY 1.11630507893268e-05 9.34506823220783e-05 1.71082491412217 0.703703703703704 10.1 10 1 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY 1.11630507893268e-05 9.34506823220783e-05 1.71082491412217 0.703703703703704 10.1 10 1 IFN-GAMMA%IOB%IFN-GAMMA IFN-GAMMA 1.07228001948462e-07 1.5975154866559e-06 1.7018205724689 0.7 10.1 10 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000185039358026386 0.000975897574231161 1.7018205724689 0.7 10.1 10 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000185039358026386 0.000975897574231161 1.7018205724689 0.7 10.1 10 1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0089031921741347 0.0233609131972072 1.7018205724689 0.7 10.1 10 1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 SIGNALING PATHWAY 1.07922151640522e-09 2.55804177238495e-08 1.69723345502289 0.69811320754717 10.1 10 1 TSH%NETPATH%TSH TSH 2.92105077229805e-13 2.26553261369117e-11 1.69542275076789 0.697368421052632 10.1 10 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 2.12624801384598e-10 1.69125025835418 0.695652173913043 10.1 10 1 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY 7.07839913852944e-05 0.000445483019768547 1.69125025835418 0.695652173913043 10.1 10 1 BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY 7.07839913852944e-05 0.000445483019768547 1.69125025835418 0.695652173913043 10.1 10 1 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY 6.6263690882542e-07 7.69768074261071e-06 1.68831405998899 0.694444444444444 10.1 10 1 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY 2.72424763698514e-05 0.000195744986886371 1.68311924749671 0.692307692307692 10.1 10 1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS INTEGRIN FAMILY CELL SURFACE INTERACTIONS 2.72424763698514e-05 0.000195744986886371 1.68311924749671 0.692307692307692 10.1 10 1 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- AND CXCR1-MEDIATED SIGNALING EVENTS 2.72424763698514e-05 0.000195744986886371 1.68311924749671 0.692307692307692 10.1 10 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.72424763698514e-05 0.000195744986886371 1.68311924749671 0.692307692307692 10.1 10 1 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY 0.00323238487766256 0.010614942618177 1.68311924749671 0.692307692307692 10.1 10 1 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY 0.00323238487766256 0.010614942618177 1.68311924749671 0.692307692307692 10.1 10 1 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY 0.00323238487766256 0.010614942618177 1.68311924749671 0.692307692307692 10.1 10 1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY 0.00323238487766256 0.010614942618177 1.68311924749671 0.692307692307692 10.1 10 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00323238487766256 0.010614942618177 1.68311924749671 0.692307692307692 10.1 10 1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES 4.01277546750624e-08 6.57247758249314e-07 1.67480754750907 0.688888888888889 10.1 10 1 LEISHMANIASIS%KEGG%HSA05140 LEISHMANIASIS 1.61802824667487e-10 5.20334205668491e-09 1.67392187455957 0.688524590163934 10.1 10 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.58081463011138e-08 2.89486679139147e-07 1.6714309193891 0.6875 10.1 10 1 SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP 4.09090915955531e-06 3.8254352672863e-05 1.6714309193891 0.6875 10.1 10 1 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY 0.00119824335019407 0.004730191189314 1.6714309193891 0.6875 10.1 10 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00119824335019407 0.004730191189314 1.6714309193891 0.6875 10.1 10 1 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-BETA SIGNALING PATHWAY 3.05045514760612e-19 4.46891679124297e-17 1.66766360702383 0.685950413223141 10.1 10 1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY P53 PATHWAY 2.46238252988908e-09 5.41108560943124e-08 1.6658032058558 0.685185185185185 10.1 10 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.01583472965257e-12 2.12624801384598e-10 1.66518647012612 0.684931506849315 10.1 10 1 IL5%NETPATH%IL5 IL5 9.7336793361193e-10 2.35483600085749e-08 1.66343364226283 0.684210526315789 10.1 10 1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM 0.000450479886934516 0.00206235323237208 1.66343364226283 0.684210526315789 10.1 10 1 CCR7%IOB%CCR7 CCR7 0.000450479886934516 0.00206235323237208 1.66343364226283 0.684210526315789 10.1 10 1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-CADHERIN SIGNALING IN KERATINOCYTES 0.000450479886934516 0.00206235323237208 1.66343364226283 0.684210526315789 10.1 10 1 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY 0.000171084587154273 0.00091141425520367 1.65761744071646 0.681818181818182 10.1 10 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000171084587154273 0.00091141425520367 1.65761744071646 0.681818181818182 10.1 10 1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FOXO FAMILY SIGNALING 3.75990525527505e-08 6.19679384885018e-07 1.6552662103041 0.680851063829787 10.1 10 1 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY 6.54744404798791e-05 0.000419068202780197 1.65319712754122 0.68 10.1 10 1 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY 6.54744404798791e-05 0.000419068202780197 1.65319712754122 0.68 10.1 10 1 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY 6.54744404798791e-05 0.000419068202780197 1.65319712754122 0.68 10.1 10 1 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS 6.54744404798791e-05 0.000419068202780197 1.65319712754122 0.68 10.1 10 1 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT INSULIN-MEDIATED GLUCOSE TRANSPORT 6.54744404798791e-05 0.000419068202780197 1.65319712754122 0.68 10.1 10 1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING ALPHA-SYNUCLEIN SIGNALING 2.52074663176211e-05 0.000185676225361918 1.6497240243321 0.678571428571429 10.1 10 1 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA 3.78709684621715e-06 3.57941734174718e-05 1.6446165196128 0.676470588235294 10.1 10 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.7650986531379e-07 6.84800231906515e-06 1.6410412663093 0.675 10.1 10 1 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY CERAMIDE SIGNALING PATHWAY 2.25771675565123e-07 3.08476636510482e-06 1.63962779407303 0.674418604651163 10.1 10 1 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-MEDIATED SIGNALING EVENTS 1.37108050638018e-08 2.5283491575696e-07 1.63636593506625 0.673076923076923 10.1 10 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.07159539687813e-11 8.27696524479943e-10 1.6318827407236 0.671232876712329 10.1 10 1 SHIGELLOSIS%KEGG%HSA05131 SHIGELLOSIS 4.96212584279034e-09 9.83844048679558e-08 1.62078149758943 0.666666666666667 10.1 10 1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 5.94013275309009e-05 0.000389654976863148 1.62078149758943 0.666666666666667 10.1 10 1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY 5.94013275309009e-05 0.000389654976863148 1.62078149758943 0.666666666666667 10.1 10 1 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY 0.000405911718846759 0.00189942836044852 1.62078149758943 0.666666666666667 10.1 10 1 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY 0.000405911718846759 0.00189942836044852 1.62078149758943 0.666666666666667 10.1 10 1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00782985415080075 0.0211984860325068 1.62078149758943 0.666666666666667 10.1 10 1 GLYCOGENOLYSIS%HUMANCYC%PWY-5941-1 GLYCOGENOLYSIS 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 NORADRENALINE AND ADRENALINE DEGRADATION 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 ST_JAK_STAT_PATHWAY%MSIGDB_C2%ST_JAK_STAT_PATHWAY ST_JAK_STAT_PATHWAY 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0218727664719912 0.0501988556889825 1.62078149758943 0.666666666666667 10.1 10 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 2.29229484265774e-05 0.000170756539550521 1.62078149758943 0.666666666666667 10.1 10 1 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY 0.00287572401185003 0.0096849096031271 1.62078149758943 0.666666666666667 10.1 10 1 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY 0.00287572401185003 0.0096849096031271 1.62078149758943 0.666666666666667 10.1 10 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00287572401185003 0.0096849096031271 1.62078149758943 0.666666666666667 10.1 10 1 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM%KEGG%HSA04070 PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 1.10820226353624e-10 3.69915109993046e-09 1.60936754338105 0.661971830985915 10.1 10 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.90248955640288e-08 4.97004218197038e-07 1.60549110610273 0.660377358490566 10.1 10 1 CXCR4%IOB%CXCR4 CXCR4 3.95243867326176e-13 2.97788022325465e-11 1.60297071190163 0.659340659340659 10.1 10 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.58455314595104e-11 6.5288541341764e-10 1.60026527610095 0.658227848101266 10.1 10 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.58455314595104e-11 6.5288541341764e-10 1.60026527610095 0.658227848101266 10.1 10 1 IFN-ALPHA%IOB%IFN-ALPHA IFN-ALPHA 7.99113857471867e-06 6.95466416552248e-05 1.59762747619529 0.657142857142857 10.1 10 1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION 4.08623013083215e-09 8.23777443797286e-08 1.59421130910435 0.655737704918033 10.1 10 1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY 5.30834931549706e-05 0.000352597409193092 1.5928369890103 0.655172413793103 10.1 10 1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING NONGENOTROPIC ANDROGEN SIGNALING 5.30834931549706e-05 0.000352597409193092 1.5928369890103 0.655172413793103 10.1 10 1 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA REGULATION OF P38-ALPHA AND P38-BETA 5.30834931549706e-05 0.000352597409193092 1.5928369890103 0.655172413793103 10.1 10 1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING RETINOIC ACID RECEPTORS-MEDIATED SIGNALING 5.30834931549706e-05 0.000352597409193092 1.5928369890103 0.655172413793103 10.1 10 1 GM-CSF%IOB%GM-CSF GM-CSF 3.60666076010636e-11 1.34056625425642e-09 1.58961262263578 0.653846153846154 10.1 10 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000137690372687708 0.00079104469014703 1.58961262263578 0.653846153846154 10.1 10 1 NOTCH%NETPATH%NOTCH NOTCH 2.28782755730958e-10 6.77865311081501e-09 1.58701521638965 0.652777777777778 10.1 10 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 4.2817787367078e-07 5.27619183584041e-06 1.58554711720705 0.652173913043478 10.1 10 1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 0.000359148204221106 0.00170951952081418 1.58554711720705 0.652173913043478 10.1 10 1 GLYCOSYLPHOSPHATIDYLINOSITOL(GPI)-ANCHOR BIOSYNTHESIS%KEGG%HSA00563 GLYCOSYLPHOSPHATIDYLINOSITOL(GPI)-ANCHOR BIOSYNTHESIS 0.000359148204221106 0.00170951952081418 1.58554711720705 0.652173913043478 10.1 10 1 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY 0.000359148204221106 0.00170951952081418 1.58554711720705 0.652173913043478 10.1 10 1 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC PATHWAY 0.000359148204221106 0.00170951952081418 1.58554711720705 0.652173913043478 10.1 10 1 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 P53 PATHWAY FEEDBACK LOOPS 2 1.090265619312e-06 1.16871156021371e-05 1.58308890462223 0.651162790697674 10.1 10 1 IL4%NETPATH%IL4 IL4 3.24260201256324e-11 1.23923789958395e-09 1.58026196014969 0.65 10.1 10 1 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-GAMMA PATHWAY 2.78143505479178e-06 2.76779027905129e-05 1.58026196014969 0.65 10.1 10 1 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY 0.000943440869192479 0.00383336451781289 1.58026196014969 0.65 10.1 10 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000943440869192479 0.00383336451781289 1.58026196014969 0.65 10.1 10 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000943440869192479 0.00383336451781289 1.58026196014969 0.65 10.1 10 1 NON-SMALL CELL LUNG CANCER%KEGG%HSA05223 NON-SMALL CELL LUNG CANCER 1.50260361097418e-07 2.13030415168759e-06 1.57311145354268 0.647058823529412 10.1 10 1 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY 0.00250125750576607 0.0085217261533658 1.57311145354268 0.647058823529412 10.1 10 1 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY 0.00250125750576607 0.0085217261533658 1.57311145354268 0.647058823529412 10.1 10 1 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY 0.00250125750576607 0.0085217261533658 1.57311145354268 0.647058823529412 10.1 10 1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA 0.00250125750576607 0.0085217261533658 1.57311145354268 0.647058823529412 10.1 10 1 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 AXON GUIDANCE MEDIATED BY SEMAPHORINS 0.00250125750576607 0.0085217261533658 1.57311145354268 0.647058823529412 10.1 10 1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 3.27901284186242e-09 6.86250544761207e-08 1.5709112976636 0.646153846153846 10.1 10 1 AMYOTROPHIC LATERAL SCLEROSIS (ALS)%KEGG%HSA05014 AMYOTROPHIC LATERAL SCLEROSIS (ALS) 3.81088824798517e-07 4.78538681425567e-06 1.57013207578976 0.645833333333333 10.1 10 1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 INTERFERON-GAMMA SIGNALING PATHWAY 0.000120950277714804 0.000700979961173493 1.56289644410409 0.642857142857143 10.1 10 1 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN) 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT SIGNALING PATHWAY 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00671467196056379 0.0189984870815523 1.56289644410409 0.642857142857143 10.1 10 1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING INTEGRIN-LINKED KINASE SIGNALING 2.4617276186215e-06 2.47770066042171e-05 1.56289644410409 0.642857142857143 10.1 10 1 TUBERCULOSIS%KEGG%HSA05152 TUBERCULOSIS 9.840088831383e-19 1.36570074991352e-16 1.56054975274658 0.641891891891892 10.1 10 1 IL1%NETPATH%IL1 IL1 2.91343001911252e-09 6.19573787129009e-08 1.56030457603758 0.641791044776119 10.1 10 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.91343001911252e-09 6.19573787129009e-08 1.56030457603758 0.641791044776119 10.1 10 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.08600812731919e-10 1.06681222096443e-08 1.55595023768585 0.64 10.1 10 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.08600812731919e-10 1.06681222096443e-08 1.55595023768585 0.64 10.1 10 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.08600812731919e-10 1.06681222096443e-08 1.55595023768585 0.64 10.1 10 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.08600812731919e-10 1.06681222096443e-08 1.55595023768585 0.64 10.1 10 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.08600812731919e-10 1.06681222096443e-08 1.55595023768585 0.64 10.1 10 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000313478481196446 0.001542243945737 1.55595023768585 0.64 10.1 10 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000313478481196446 0.001542243945737 1.55595023768585 0.64 10.1 10 1 COLORECTAL CANCER%KEGG%HSA05210 COLORECTAL CANCER 1.84669502624745e-08 3.33543478370857e-07 1.55435602637675 0.639344262295082 10.1 10 1 GDNF%IOB%GDNF GDNF 1.60152389486855e-05 0.000126443667987077 1.55324893518987 0.638888888888889 10.1 10 1 PATHOGENIC ESCHERICHIA COLI INFECTION%KEGG%HSA05130 PATHOGENIC ESCHERICHIA COLI INFECTION 8.53083061093058e-07 9.53211878009489e-06 1.55181207216009 0.638297872340426 10.1 10 1 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 TRANSCRIPTION FACTOR NETWORK 4.653129381699e-08 7.48189157289041e-07 1.55092022614161 0.637931034482759 10.1 10 1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY 4.09861765535121e-05 0.000280728694991199 1.54710961133536 0.636363636363636 10.1 10 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 4.09861765535121e-05 0.000280728694991199 1.54710961133536 0.636363636363636 10.1 10 1 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY 0.000816859199308617 0.0033908980736998 1.54710961133536 0.636363636363636 10.1 10 1 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY 0.000816859199308617 0.0033908980736998 1.54710961133536 0.636363636363636 10.1 10 1 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY 0.000816859199308617 0.0033908980736998 1.54710961133536 0.636363636363636 10.1 10 1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 ENDOGENOUS_CANNABINOID_SIGNALING 0.000816859199308617 0.0033908980736998 1.54710961133536 0.636363636363636 10.1 10 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000816859199308617 0.0033908980736998 1.54710961133536 0.636363636363636 10.1 10 1 THROMBOPOIETIN%IOB%THROMBOPOIETIN THROMBOPOIETIN 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0183500550948401 0.0433982917355097 1.54710961133536 0.636363636363636 10.1 10 1 RIG-I-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04622 RIG-I-LIKE RECEPTOR SIGNALING PATHWAY 1.17317468394534e-07 1.71133623465008e-06 1.54710961133536 0.636363636363636 10.1 10 1 NOTCH%IOB%NOTCH NOTCH 9.04864407257204e-10 2.20937726105301e-08 1.54412291324398 0.635135135135135 10.1 10 1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS ENDOTHELINS 4.0885414589375e-08 6.6552369303816e-07 1.53974242270996 0.633333333333333 10.1 10 1 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY 0.000105178979504014 0.000626087966031793 1.53974242270996 0.633333333333333 10.1 10 1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING AURORA A SIGNALING 0.000105178979504014 0.000626087966031793 1.53974242270996 0.633333333333333 10.1 10 1 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 FORWARD SIGNALING 0.0021430208594364 0.00754492123676074 1.53547720824262 0.631578947368421 10.1 10 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0021430208594364 0.00754492123676074 1.53547720824262 0.631578947368421 10.1 10 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0021430208594364 0.00754492123676074 1.53547720824262 0.631578947368421 10.1 10 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.7871059088462e-10 7.98869378437764e-09 1.53073808105668 0.62962962962963 10.1 10 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.7871059088462e-10 7.98869378437764e-09 1.53073808105668 0.62962962962963 10.1 10 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000270781749454283 0.00136529918415095 1.53073808105668 0.62962962962963 10.1 10 1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L SIGNALING 3.55561398492612e-05 0.000249365799953462 1.52816541201289 0.628571428571429 10.1 10 1 PARKINSON DISEASE%PANTHER PATHWAY%P00049 PARKINSON DISEASE 6.96003785723951e-10 1.74796379328958e-08 1.5272748727285 0.628205128205128 10.1 10 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.51146342749904e-07 7.59766772491813e-06 1.52544140949593 0.627450980392157 10.1 10 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.51146342749904e-07 7.59766772491813e-06 1.52544140949593 0.627450980392157 10.1 10 1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-BETA RECEPTOR SIGNALING 1.63974012158397e-06 1.70908881447309e-05 1.51948265399009 0.625 10.1 10 1 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 SIGNALING EVENTS 1.20911887457102e-05 9.75060083254981e-05 1.51948265399009 0.625 10.1 10 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.20911887457102e-05 9.75060083254981e-05 1.51948265399009 0.625 10.1 10 1 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 P38 MAPK PATHWAY 9.07269067530448e-05 0.00055054622823928 1.51948265399009 0.625 10.1 10 1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS 0.000699802052693214 0.00296208348788444 1.51948265399009 0.625 10.1 10 1 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY 0.000699802052693214 0.00296208348788444 1.51948265399009 0.625 10.1 10 1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY 0.000699802052693214 0.00296208348788444 1.51948265399009 0.625 10.1 10 1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK GLYPICAN 1 NETWORK 0.000699802052693214 0.00296208348788444 1.51948265399009 0.625 10.1 10 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000699802052693214 0.00296208348788444 1.51948265399009 0.625 10.1 10 1 STEROID BIOSYNTHESIS%KEGG%HSA00100 STEROID BIOSYNTHESIS 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00567152511460996 0.016471158289897 1.51948265399009 0.625 10.1 10 1 SUCROSE DEGRADATION%HUMANCYC%PWY66-373 SUCROSE DEGRADATION 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 ST_INTERFERON_GAMMA_PATHWAY%MSIGDB_C2%ST_INTERFERON_GAMMA_PATHWAY ST_INTERFERON_GAMMA_PATHWAY 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING A4B7 INTEGRIN SIGNALING 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 PENTOSE PHOSPHATE PATHWAY 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0515471314663788 0.101440138564807 1.51948265399009 0.625 10.1 10 1 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 4.94010216185149e-21 8.14190587550149e-19 1.51621494935785 0.623655913978495 10.1 10 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.98877628351022e-11 1.1590298617083e-09 1.51621494935785 0.623655913978495 10.1 10 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.12334349839201e-10 6.43592736236752e-09 1.51590740068658 0.623529411764706 10.1 10 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.12334349839201e-10 6.43592736236752e-09 1.51590740068658 0.623529411764706 10.1 10 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.12334349839201e-10 6.43592736236752e-09 1.51590740068658 0.623529411764706 10.1 10 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.12334349839201e-10 6.43592736236752e-09 1.51590740068658 0.623529411764706 10.1 10 1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING THROMBOXANE A2 RECEPTOR SIGNALING 5.64653032524676e-07 6.73751152383516e-06 1.51374875718258 0.622641509433962 10.1 10 1 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B SIGNALING EVENTS MEDIATED BY PTP1B 5.64653032524676e-07 6.73751152383516e-06 1.51374875718258 0.622641509433962 10.1 10 1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 4.13126237580255e-06 3.83596439612371e-05 1.51272939775013 0.622222222222222 10.1 10 1 SMALL CELL LUNG CANCER%KEGG%HSA05222 SMALL CELL LUNG CANCER 5.28262242036238e-10 1.3524539148054e-08 1.51207054348282 0.621951219512195 10.1 10 1 GASTRIC ACID SECRETION%KEGG%HSA04971 GASTRIC ACID SECRETION 2.70295638451766e-08 4.65862482743338e-07 1.51027366820833 0.621212121212121 10.1 10 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.31376950560657e-09 3.01253059676914e-08 1.50794227940282 0.620253164556962 10.1 10 1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-MEDIATED THROMBIN SIGNALING EVENTS 1.04137142163064e-05 8.85837560916131e-05 1.50501139061875 0.619047619047619 10.1 10 1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING 1.04137142163064e-05 8.85837560916131e-05 1.50501139061875 0.619047619047619 10.1 10 1 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY 0.00181692573850427 0.00652050179667648 1.50501139061875 0.619047619047619 10.1 10 1 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.00181692573850427 0.00652050179667648 1.50501139061875 0.619047619047619 10.1 10 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00181692573850427 0.00652050179667648 1.50501139061875 0.619047619047619 10.1 10 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00181692573850427 0.00652050179667648 1.50501139061875 0.619047619047619 10.1 10 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00181692573850427 0.00652050179667648 1.50501139061875 0.619047619047619 10.1 10 1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I SIGNALING EVENTS MEDIATED BY HDAC CLASS I 6.74417044667543e-08 1.03773683808457e-06 1.50501139061875 0.619047619047619 10.1 10 1 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY REGULATION OF RAC1 ACTIVITY 7.77468525237611e-05 0.000479015070339154 1.50160638747256 0.617647058823529 10.1 10 1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS CASPASE CASCADE IN APOPTOSIS 3.55642869288961e-06 3.39793567505432e-05 1.50008500308809 0.617021276595745 10.1 10 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.55642869288961e-06 3.39793567505432e-05 1.50008500308809 0.617021276595745 10.1 10 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.55642869288961e-06 3.39793567505432e-05 1.50008500308809 0.617021276595745 10.1 10 1 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK 1.6822506273201e-07 2.34714016097518e-06 1.49922288527022 0.616666666666667 10.1 10 1 TNFALPHA%NETPATH%TNFALPHA TNFALPHA 1.88447779837934e-27 7.16525369259926e-25 1.49828057044604 0.616279069767442 10.1 10 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.81709630677332e-08 9.02334291821249e-07 1.49610599777486 0.615384615384615 10.1 10 1 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY 2.62627708684951e-05 0.000191311952431551 1.49610599777486 0.615384615384615 10.1 10 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 6.82795899936387e-12 3.05175048835975e-10 1.49610599777486 0.615384615384615 10.1 10 1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 SA_REG_CASCADE_OF_CYCLIN_EXPR%MSIGDB_C2%SA_REG_CASCADE_OF_CYCLIN_EXPR SA_REG_CASCADE_OF_CYCLIN_EXPR 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0151858049878219 0.0367385025255837 1.49610599777486 0.615384615384615 10.1 10 1 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE 4.19464241098527e-07 5.19308546374092e-06 1.49282506356921 0.614035087719298 10.1 10 1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY 8.92639331915355e-06 7.69245071327056e-05 1.49185569664481 0.613636363636364 10.1 10 1 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY 0.000197499608156733 0.00102319541593184 1.49007331229996 0.612903225806452 10.1 10 1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO SIGNALING PATHWAY 0.000197499608156733 0.00102319541593184 1.49007331229996 0.612903225806452 10.1 10 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.0488208633056e-06 3.01113880769171e-05 1.48847280390866 0.612244897959184 10.1 10 1 P53 PATHWAY%PANTHER PATHWAY%P00059 P53 PATHWAY 1.04544644164629e-06 1.12985338795954e-05 1.48571637279031 0.611111111111111 10.1 10 1 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00474401590766947 0.0143792758029016 1.48571637279031 0.611111111111111 10.1 10 1 TNFALPHA%IOB%TNFALPHA TNFALPHA 2.9322712786582e-21 5.15493290788111e-19 1.48505102734795 0.610837438423645 10.1 10 1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB TRANSCRIPTION FACTOR NETWORK 6.01168770717959e-09 1.16564856498769e-07 1.48396228026045 0.61038961038961 10.1 10 1 RANKL%NETPATH%RANKL RANKL 6.01168770717959e-09 1.16564856498769e-07 1.48396228026045 0.61038961038961 10.1 10 1 IL6%NETPATH%IL6 IL6 2.08882576775149e-09 4.66114334679943e-08 1.48242210145374 0.609756097560976 10.1 10 1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 TRANSCRIPTION FACTOR NETWORK 4.28911519120371e-08 6.93889371730317e-07 1.47984397605991 0.608695652173913 10.1 10 1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-MEDIATED SIGNALING EVENTS 7.62014864026138e-06 6.85541610666957e-05 1.47984397605991 0.608695652173913 10.1 10 1 FSH%NETPATH%FSH FSH 7.62014864026138e-06 6.85541610666957e-05 1.47984397605991 0.608695652173913 10.1 10 1 CCR1%IOB%CCR1 CCR1 0.00152885408055584 0.00567030690636534 1.47984397605991 0.608695652173913 10.1 10 1 ST_INTERLEUKIN_4_PATHWAY%MSIGDB_C2%ST_INTERLEUKIN_4_PATHWAY ST_INTERLEUKIN_4_PATHWAY 0.00152885408055584 0.00567030690636534 1.47984397605991 0.608695652173913 10.1 10 1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY CANONICAL NF-KAPPAB PATHWAY 0.00152885408055584 0.00567030690636534 1.47984397605991 0.608695652173913 10.1 10 1 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING ENDOGENOUS TLR SIGNALING 0.00152885408055584 0.00567030690636534 1.47984397605991 0.608695652173913 10.1 10 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00152885408055584 0.00567030690636534 1.47984397605991 0.608695652173913 10.1 10 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00152885408055584 0.00567030690636534 1.47984397605991 0.608695652173913 10.1 10 1 NEUROTROPHIN SIGNALING PATHWAY%KEGG%HSA04722 NEUROTROPHIN SIGNALING PATHWAY 5.34299054337761e-13 3.9137405730241e-11 1.47896311655035 0.608333333333333 10.1 10 1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ERBB1 DOWNSTREAM SIGNALING 8.82184186568203e-11 3.06094697365836e-09 1.4787542529553 0.608247422680412 10.1 10 1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 6.55478295793597e-22 1.44041355500643e-19 1.4768803365885 0.607476635514019 10.1 10 1 OSTEOCLAST DIFFERENTIATION%KEGG%HSA04380 OSTEOCLAST DIFFERENTIATION 3.7533974095211e-12 2.12624801384598e-10 1.47606886387609 0.607142857142857 10.1 10 1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 ST_ERK1_ERK2_MAPK_PATHWAY%MSIGDB_C2%ST_ERK1_ERK2_MAPK_PATHWAY ST_ERK1_ERK2_MAPK_PATHWAY 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION REGULATION OF RAS FAMILY ACTIVATION 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 IL-7%NETPATH%IL-7 IL-7 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 AXON GUIDANCE MEDIATED BY NETRIN 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000502339478506203 0.00221641855491762 1.47606886387609 0.607142857142857 10.1 10 1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA RECEPTOR MEDIATED EVENTS 3.07438250640997e-07 4.03340630318562e-06 1.47464546092153 0.60655737704918 10.1 10 1 BCR%NETPATH%BCR BCR 3.44781516518814e-16 3.95299503939179e-14 1.47438833006522 0.606451612903226 10.1 10 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 7.56445183993025e-11 2.65966126691948e-09 1.4734377250813 0.606060606060606 10.1 10 1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS 1.06080808025513e-07 1.58940392479135e-06 1.4734377250813 0.606060606060606 10.1 10 1 ST_P38_MAPK_PATHWAY%MSIGDB_C2%ST_P38_MAPK_PATHWAY ST_P38_MAPK_PATHWAY 0.000167251107060018 0.000894606834314943 1.4734377250813 0.606060606060606 10.1 10 1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA 0.000167251107060018 0.000894606834314943 1.4734377250813 0.606060606060606 10.1 10 1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 SIGNALING EVENTS MEDIATED BY PI3K 0.000167251107060018 0.000894606834314943 1.4734377250813 0.606060606060606 10.1 10 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000167251107060018 0.000894606834314943 1.4734377250813 0.606060606060606 10.1 10 1 ADHERENS JUNCTION%KEGG%HSA04520 ADHERENS JUNCTION 3.66842480126219e-08 6.12255455754961e-07 1.47240009288054 0.605633802816901 10.1 10 1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-MEDIATED SIGNALING EVENTS 4.41066687631972e-09 8.81130950973872e-08 1.47070913670152 0.604938271604938 10.1 10 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.53274582053254e-09 3.4843540765037e-08 1.47001112572064 0.604651162790698 10.1 10 1 G-CSF%IOB%G-CSF G-CSF 1.90359939998417e-05 0.00014466258264433 1.47001112572064 0.604651162790698 10.1 10 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.90359939998417e-05 0.00014466258264433 1.47001112572064 0.604651162790698 10.1 10 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.90359939998417e-05 0.00014466258264433 1.47001112572064 0.604651162790698 10.1 10 1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 7.61140592526554e-07 8.65141268315743e-06 1.46708670040422 0.603448275862069 10.1 10 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.61140592526554e-07 8.65141268315743e-06 1.46708670040422 0.603448275862069 10.1 10 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.61140592526554e-07 8.65141268315743e-06 1.46708670040422 0.603448275862069 10.1 10 1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK GLUCOCORTICOID RECEPTOR REGULATORY NETWORK 1.08490185097415e-08 2.02899729150272e-07 1.46493712282121 0.602564102564103 10.1 10 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 9.24193845142765e-09 1.74078512117248e-07 1.45870334783048 0.6 10.1 10 1 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY 4.75201440526722e-05 0.000321309281709991 1.45870334783048 0.6 10.1 10 1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION 4.75201440526722e-05 0.000321309281709991 1.45870334783048 0.6 10.1 10 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.75201440526722e-05 0.000321309281709991 1.45870334783048 0.6 10.1 10 1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III SIGNALING EVENTS MEDIATED BY HDAC CLASS III 0.00127928740993837 0.00497419817724688 1.45870334783048 0.6 10.1 10 1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR 0.00127928740993837 0.00497419817724688 1.45870334783048 0.6 10.1 10 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00127928740993837 0.00497419817724688 1.45870334783048 0.6 10.1 10 1 BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY 0.0039423908448023 0.0123615750983872 1.45870334783048 0.6 10.1 10 1 BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY 0.0039423908448023 0.0123615750983872 1.45870334783048 0.6 10.1 10 1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-ALPHA SIGNALING PATHWAY 0.0039423908448023 0.0123615750983872 1.45870334783048 0.6 10.1 10 1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY CANONICAL WNT SIGNALING PATHWAY 0.0039423908448023 0.0123615750983872 1.45870334783048 0.6 10.1 10 1 FOLATE BIOSYNTHESIS%KEGG%HSA00790 FOLATE BIOSYNTHESIS 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF AND VEGFR SIGNALING NETWORK 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0413271279187761 0.0846115188833949 1.45870334783048 0.6 10.1 10 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.45796789456334e-13 1.96413979938288e-11 1.45870334783048 0.6 10.1 10 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.61190897341801e-05 0.000126506070324503 1.45870334783048 0.6 10.1 10 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.61190897341801e-05 0.000126506070324503 1.45870334783048 0.6 10.1 10 1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN 0.000141032921535509 0.000803247978594252 1.45870334783048 0.6 10.1 10 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000141032921535509 0.000803247978594252 1.45870334783048 0.6 10.1 10 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000141032921535509 0.000803247978594252 1.45870334783048 0.6 10.1 10 1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 APOPTOSIS SIGNALING PATHWAY 3.88487713509182e-10 1.06681222096443e-08 1.45870334783048 0.6 10.1 10 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.88487713509182e-10 1.06681222096443e-08 1.45870334783048 0.6 10.1 10 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.88487713509182e-10 1.06681222096443e-08 1.45870334783048 0.6 10.1 10 1 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY ARF6 DOWNSTREAM PATHWAY 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0124730938836344 0.0311384208894587 1.45870334783048 0.6 10.1 10 1 KITRECEPTOR%NETPATH%KITRECEPTOR KITRECEPTOR 1.15291981528414e-10 3.80031194113033e-09 1.45393634342581 0.598039215686274 10.1 10 1 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING A6B1 AND A6B4 INTEGRIN SIGNALING 4.00365172608964e-05 0.000276129733619238 1.44712633713342 0.595238095238095 10.1 10 1 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY INSULIN PATHWAY 4.00365172608964e-05 0.000276129733619238 1.44712633713342 0.595238095238095 10.1 10 1 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY 0.000118506710605607 0.000688330827900852 1.44556187622841 0.594594594594595 10.1 10 1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY 0.000118506710605607 0.000688330827900852 1.44556187622841 0.594594594594595 10.1 10 1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-MEDIATED SIGNALING EVENTS 0.000118506710605607 0.000688330827900852 1.44556187622841 0.594594594594595 10.1 10 1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM PATHWAY 0.000353552017900586 0.00169820887286675 1.44350852129058 0.59375 10.1 10 1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II SIGNALING EVENTS MEDIATED BY HDAC CLASS II 0.000353552017900586 0.00169820887286675 1.44350852129058 0.59375 10.1 10 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.01450612059043e-12 2.03826990769153e-10 1.44289084541498 0.59349593495935 10.1 10 1 LYSOSOME%KEGG%HSA04142 LYSOSOME 8.62173853526142e-12 3.66702008346522e-10 1.44222082412619 0.593220338983051 10.1 10 1 P53 SIGNALING PATHWAY%KEGG%HSA04115 P53 SIGNALING PATHWAY 1.34664783969824e-06 1.4204441413137e-05 1.44222082412619 0.593220338983051 10.1 10 1 GLIOMA%KEGG%HSA05214 GLIOMA 1.34664783969824e-06 1.4204441413137e-05 1.44222082412619 0.593220338983051 10.1 10 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 3.92134544873586e-06 3.68778933447587e-05 1.44069466452394 0.592592592592593 10.1 10 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00106595066260118 0.00425251421676142 1.44069466452394 0.592592592592593 10.1 10 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00106595066260118 0.00425251421676142 1.44069466452394 0.592592592592593 10.1 10 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00106595066260118 0.00425251421676142 1.44069466452394 0.592592592592593 10.1 10 1 APOPTOSIS%KEGG%HSA04210 APOPTOSIS 4.68923557291329e-08 7.49425103380142e-07 1.43950988272745 0.592105263157895 10.1 10 1 LEPTIN%IOB%LEPTIN LEPTIN 1.14598665190109e-05 9.42017771387079e-05 1.43885704377837 0.591836734693878 10.1 10 1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY REGULATION OF ANDROGEN RECEPTOR ACTIVITY 1.14598665190109e-05 9.42017771387079e-05 1.43885704377837 0.591836734693878 10.1 10 1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS 1.14598665190109e-05 9.42017771387079e-05 1.43885704377837 0.591836734693878 10.1 10 1 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 SIGNALING EVENTS 3.91620932587605e-07 4.89433364565646e-06 1.43660178195427 0.590909090909091 10.1 10 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.36387505386138e-05 0.000236547693787532 1.43660178195427 0.590909090909091 10.1 10 1 GLYCOSPHINGOLIPID BIOSYNTHESIS - LACTO AND NEOLACTO SERIES%KEGG%HSA00601 GLYCOSPHINGOLIPID BIOSYNTHESIS - LACTO AND NEOLACTO SERIES 0.00326146629512021 0.010644166609198 1.43660178195427 0.590909090909091 10.1 10 1 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY 0.00326146629512021 0.010644166609198 1.43660178195427 0.590909090909091 10.1 10 1 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA REPLICATION 0.00326146629512021 0.010644166609198 1.43660178195427 0.590909090909091 10.1 10 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00326146629512021 0.010644166609198 1.43660178195427 0.590909090909091 10.1 10 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00326146629512021 0.010644166609198 1.43660178195427 0.590909090909091 10.1 10 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.7136268479109e-10 5.44437831077233e-09 1.43554932643635 0.59047619047619 10.1 10 1 ALDOSTERONE-REGULATED SODIUM REABSORPTION%KEGG%HSA04960 ALDOSTERONE-REGULATED SODIUM REABSORPTION 9.92865026553805e-05 0.00059775914954849 1.43376824786757 0.58974358974359 10.1 10 1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING 9.92865026553805e-05 0.00059775914954849 1.43376824786757 0.58974358974359 10.1 10 1 INOSITOL PHOSPHATE METABOLISM%KEGG%HSA00562 INOSITOL PHOSPHATE METABOLISM 3.30106295841955e-06 3.22713246985066e-05 1.43265507376208 0.589285714285714 10.1 10 1 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY 3.30106295841955e-06 3.22713246985066e-05 1.43265507376208 0.589285714285714 10.1 10 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.24041177038777e-12 2.38258031698492e-10 1.4312546289197 0.588709677419355 10.1 10 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.24041177038777e-12 2.38258031698492e-10 1.4312546289197 0.588709677419355 10.1 10 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.24041177038777e-12 2.38258031698492e-10 1.4312546289197 0.588709677419355 10.1 10 1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) SIGNALING PATHWAY 0.000295114327826101 0.00146556776361097 1.43010132140244 0.588235294117647 10.1 10 1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 0.000295114327826101 0.00146556776361097 1.43010132140244 0.588235294117647 10.1 10 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000295114327826101 0.00146556776361097 1.43010132140244 0.588235294117647 10.1 10 1 SUPERPATHWAY OF METHIONINE DEGRADATION%HUMANCYC%PWY-5328 SUPERPATHWAY OF METHIONINE DEGRADATION 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 PANTOTHENATE AND COA BIOSYNTHESIS%KEGG%HSA00770 PANTOTHENATE AND COA BIOSYNTHESIS 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN CELLULAR ROLES OF ANTHRAX TOXIN 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0102004788415298 0.0261152065098195 1.43010132140244 0.588235294117647 10.1 10 1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING REGULATION OF NUCLEAR SMAD2 3 SIGNALING 3.34118653084789e-08 5.68432831086831e-07 1.42831369475068 0.5875 10.1 10 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.50378526096919e-10 9.93492659481263e-09 1.42597602912916 0.586538461538462 10.1 10 1 M-CSF%IOB%M-CSF M-CSF 2.77360262771542e-06 2.76779027905129e-05 1.42516993753553 0.586206896551724 10.1 10 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000885313300268952 0.0036194901904019 1.42516993753553 0.586206896551724 10.1 10 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.03324822650191e-10 3.49317381190454e-09 1.42365942355828 0.585585585585586 10.1 10 1 FOCAL ADHESION%KEGG%HSA04510 FOCAL ADHESION 1.59909586425996e-17 2.00800752097787e-15 1.42343245513683 0.585492227979275 10.1 10 1 ABC TRANSPORTERS%KEGG%HSA02010 ABC TRANSPORTERS 8.29783760314734e-05 0.000506513837025452 1.42312521739559 0.585365853658537 10.1 10 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 8.29783760314734e-05 0.000506513837025452 1.42312521739559 0.585365853658537 10.1 10 1 NOD-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04621 NOD-LIKE RECEPTOR SIGNALING PATHWAY 8.07386556990321e-06 7.00354720652459e-05 1.42200640826242 0.584905660377358 10.1 10 1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE REGULATION OF TELOMERASE 8.02948520434852e-07 9.04861217259276e-06 1.42130069788611 0.584615384615385 10.1 10 1 KITRECEPTOR%IOB%KITRECEPTOR KITRECEPTOR 8.24672588538354e-09 1.57584175070699e-07 1.4204601888986 0.584269662921348 10.1 10 1 ST_B_CELL_ANTIGEN_RECEPTOR%MSIGDB_C2%ST_B_CELL_ANTIGEN_RECEPTOR ST_B_CELL_ANTIGEN_RECEPTOR 0.000245710433914992 0.00124603541198814 1.41818381039075 0.583333333333333 10.1 10 1 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY 0.000245710433914992 0.00124603541198814 1.41818381039075 0.583333333333333 10.1 10 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000245710433914992 0.00124603541198814 1.41818381039075 0.583333333333333 10.1 10 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000245710433914992 0.00124603541198814 1.41818381039075 0.583333333333333 10.1 10 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00268952691956353 0.00912072375936544 1.41818381039075 0.583333333333333 10.1 10 1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL) 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 CHOLESTEROL BIOSYNTHESIS I 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL) 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 NAD DE NOVO< I> BIOSYNTHESIS%HUMANCYC%NADSYN-PWY NAD DE NOVO< I> BIOSYNTHESIS 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0330783364164951 0.0703530202109944 1.41818381039075 0.583333333333333 10.1 10 1 LEUKOCYTE TRANSENDOTHELIAL MIGRATION%KEGG%HSA04670 LEUKOCYTE TRANSENDOTHELIAL MIGRATION 2.48935703561268e-10 7.29381611434515e-09 1.41818381039075 0.583333333333333 10.1 10 1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS DIRECT P53 EFFECTORS 7.58971892595127e-12 3.33568146795558e-10 1.41658855301123 0.582677165354331 10.1 10 1 MINERAL ABSORPTION%KEGG%HSA04978 MINERAL ABSORPTION 6.92039106790281e-05 0.000437627607819178 1.41347223626985 0.581395348837209 10.1 10 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000733428711758757 0.00308953915799975 1.41164840112628 0.580645161290323 10.1 10 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000733428711758757 0.00308953915799975 1.41164840112628 0.580645161290323 10.1 10 1 TRAIL%IOB%TRAIL TRAIL 1.96949526857713e-05 0.00014838740066394 1.4100799029028 0.58 10.1 10 1 B CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04662 B CELL RECEPTOR SIGNALING PATHWAY 5.64416378026189e-07 6.73751152383516e-06 1.40937521529515 0.579710144927536 10.1 10 1 PANCREATIC CANCER%KEGG%HSA05212 PANCREATIC CANCER 5.64416378026189e-07 6.73751152383516e-06 1.40937521529515 0.579710144927536 10.1 10 1 TOLL-LIKE RECEPTOR SIGNALING PATHWAY%KEGG%HSA04620 TOLL-LIKE RECEPTOR SIGNALING PATHWAY 1.66976018493737e-08 3.03666041908954e-07 1.40897482460899 0.579545454545455 10.1 10 1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY 0.000204149253402817 0.00105144840082662 1.4075207742224 0.578947368421053 10.1 10 1 BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY 0.00832038409898993 0.0222749775320167 1.4075207742224 0.578947368421053 10.1 10 1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY 0.00832038409898993 0.0222749775320167 1.4075207742224 0.578947368421053 10.1 10 1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 P53 PATHWAY BY GLUCOSE DEPRIVATION 0.00832038409898993 0.0222749775320167 1.4075207742224 0.578947368421053 10.1 10 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00832038409898993 0.0222749775320167 1.4075207742224 0.578947368421053 10.1 10 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 5.76130232183656e-05 0.000380765769992056 1.40467729791084 0.577777777777778 10.1 10 1 CHRONIC MYELOID LEUKEMIA%KEGG%HSA05220 CHRONIC MYELOID LEUKEMIA 4.72305334541473e-07 5.79287984737611e-06 1.40391636763028 0.577464788732394 10.1 10 1 MRNA SURVEILLANCE PATHWAY%KEGG%HSA03015 MRNA SURVEILLANCE PATHWAY 1.37401531338394e-07 1.97993354174505e-06 1.40259937291393 0.576923076923077 10.1 10 1 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF SIGNALING PATHWAY 1.64199126846744e-05 0.000127726577432113 1.40259937291393 0.576923076923077 10.1 10 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.64199126846744e-05 0.000127726577432113 1.40259937291393 0.576923076923077 10.1 10 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.64199126846744e-05 0.000127726577432113 1.40259937291393 0.576923076923077 10.1 10 1 BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY 0.00221276189420375 0.00773879723476827 1.40259937291393 0.576923076923077 10.1 10 1 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY 0.00221276189420375 0.00773879723476827 1.40259937291393 0.576923076923077 10.1 10 1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-MEDIATED SIGNALING EVENTS 0.00221276189420375 0.00773879723476827 1.40259937291393 0.576923076923077 10.1 10 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00221276189420375 0.00773879723476827 1.40259937291393 0.576923076923077 10.1 10 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.85063639246204e-18 9.0325640834612e-16 1.40081829434515 0.576190476190476 10.1 10 1 ST_G_ALPHA_I_PATHWAY%MSIGDB_C2%ST_G_ALPHA_I_PATHWAY ST_G_ALPHA_I_PATHWAY 0.000606388968327071 0.00261709936084858 1.39976583882723 0.575757575757576 10.1 10 1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-MEDIATED SIGNALING EVENTS 0.000606388968327071 0.00261709936084858 1.39976583882723 0.575757575757576 10.1 10 1 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA 0.000606388968327071 0.00261709936084858 1.39976583882723 0.575757575757576 10.1 10 1 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_RECEPTOR_II_SIGNALING 0.000606388968327071 0.00261709936084858 1.39976583882723 0.575757575757576 10.1 10 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000606388968327071 0.00261709936084858 1.39976583882723 0.575757575757576 10.1 10 1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 HUNTINGTON DISEASE 1.00939624839346e-09 2.41979809728504e-08 1.39907082103238 0.575471698113208 10.1 10 1 RIBOSOME%KEGG%HSA03010 RIBOSOME 4.78899864424695e-05 0.000322981826723254 1.39663086494408 0.574468085106383 10.1 10 1 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS)%KEGG%HSA05142 CHAGAS DISEASE (AMERICAN TRYPANOSOMIASIS) 2.87797693154298e-09 6.19573787129009e-08 1.39611871574535 0.574257425742574 10.1 10 1 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY 1.36707405158244e-05 0.000109573686140514 1.39567295625756 0.574074074074074 10.1 10 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.31932109028046e-11 2.60824996149589e-09 1.39493489546631 0.573770491803279 10.1 10 1 LONG-TERM POTENTIATION%KEGG%HSA04720 LONG-TERM POTENTIATION 3.92972621534972e-06 3.68778933447587e-05 1.39493489546631 0.573770491803279 10.1 10 1 VEGF SIGNALING PATHWAY%KEGG%HSA04370 VEGF SIGNALING PATHWAY 1.13572611339313e-06 1.21251407328651e-05 1.39434878836737 0.573529411764706 10.1 10 1 TCR%NETPATH%TCR TCR 2.1752611741631e-20 3.37421395074594e-18 1.39204217333285 0.57258064516129 10.1 10 1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF SIGNALING PATHWAY 5.91379316190177e-10 1.49948774691682e-08 1.38924128364808 0.571428571428571 10.1 10 1 EPO%IOB%EPO EPO 1.13681138401995e-05 9.42017771387079e-05 1.38924128364808 0.571428571428571 10.1 10 1 MTOR SIGNALING PATHWAY%KEGG%HSA04150 MTOR SIGNALING PATHWAY 3.97551848980562e-05 0.000276129733619238 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY 0.000140234187725576 0.000803247978594252 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY 0.00181743224139447 0.00652050179667648 1.38924128364808 0.571428571428571 10.1 10 1 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE 0.00181743224139447 0.00652050179667648 1.38924128364808 0.571428571428571 10.1 10 1 MUCIN CORE 1 AND CORE 2 O< I>-GLYCOSYLATION%HUMANCYC%PWY-7433 MUCIN CORE 1 AND CORE 2 O< I>-GLYCOSYLATION 0.00677634431986632 0.0190503411209888 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY 0.00677634431986632 0.0190503411209888 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY 0.00677634431986632 0.0190503411209888 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY 0.00677634431986632 0.0190503411209888 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY CIRCADIAN RHYTHM PATHWAY 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 CELL CYCLE%PANTHER PATHWAY%P00013 CELL CYCLE 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0264806490241659 0.0588285353637115 1.38924128364808 0.571428571428571 10.1 10 1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-MEDIATED SIGNALING EVENTS 0.000500556202880221 0.00221641855491762 1.38924128364808 0.571428571428571 10.1 10 1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS ARF6 SIGNALING EVENTS 0.000500556202880221 0.00221641855491762 1.38924128364808 0.571428571428571 10.1 10 1 IL2%NETPATH%IL2 IL2 2.2919316266607e-07 3.11537304098158e-06 1.38484495047198 0.569620253164557 10.1 10 1 FC GAMMA R-MEDIATED PHAGOCYTOSIS%KEGG%HSA04666 FC GAMMA R-MEDIATED PHAGOCYTOSIS 5.57101800182523e-08 8.71412609183905e-07 1.38134786726372 0.568181818181818 10.1 10 1 ST_T_CELL_SIGNAL_TRANSDUCTION%MSIGDB_C2%ST_T_CELL_SIGNAL_TRANSDUCTION ST_T_CELL_SIGNAL_TRANSDUCTION 0.000116000174021679 0.000679761019767037 1.38134786726372 0.568181818181818 10.1 10 1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RHOA SIGNALING PATHWAY 0.000116000174021679 0.000679761019767037 1.38134786726372 0.568181818181818 10.1 10 1 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY 0.000412665320758557 0.00191247530903394 1.37985451821803 0.567567567567568 10.1 10 1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE 0.000412665320758557 0.00191247530903394 1.37985451821803 0.567567567567568 10.1 10 1 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP SIGNALING EVENTS MEDIATED BY TCPTP 0.000412665320758557 0.00191247530903394 1.37985451821803 0.567567567567568 10.1 10 1 BACTERIAL INVASION OF EPITHELIAL CELLS%KEGG%HSA05100 BACTERIAL INVASION OF EPITHELIAL CELLS 2.26206953676653e-06 2.2922323340083e-05 1.37887381138205 0.567164179104478 10.1 10 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 7.83677978108224e-06 6.86564394774547e-05 1.37766427295101 0.566666666666667 10.1 10 1 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY 0.00149086536936843 0.00558439201565987 1.37766427295101 0.566666666666667 10.1 10 1 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0.00149086536936843 0.00558439201565987 1.37766427295101 0.566666666666667 10.1 10 1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS NETRIN-MEDIATED SIGNALING EVENTS 0.00149086536936843 0.00558439201565987 1.37766427295101 0.566666666666667 10.1 10 1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY 0.00551386217405388 0.0162640431241388 1.37414083491278 0.565217391304348 10.1 10 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00551386217405388 0.0162640431241388 1.37414083491278 0.565217391304348 10.1 10 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.76579827194485e-09 6.0276116058831e-08 1.37316210212438 0.564814814814815 10.1 10 1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR SIGNALING IN NAIVE CD4+ T CELLS 6.49810153788892e-06 5.90879095014244e-05 1.37243594553943 0.564516129032258 10.1 10 1 BLADDER CANCER%KEGG%HSA05219 BLADDER CANCER 0.000339853989664203 0.00164741722563328 1.37143049796028 0.564102564102564 10.1 10 1 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ERBB2 ERBB3 SIGNALING EVENTS 0.000339853989664203 0.00164741722563328 1.37143049796028 0.564102564102564 10.1 10 1 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 UBIQUITIN PROTEASOME PATHWAY 0.000339853989664203 0.00164741722563328 1.37143049796028 0.564102564102564 10.1 10 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.3134946281934e-13 5.21234738771514e-11 1.36753438859108 0.5625 10.1 10 1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING 7.91374141760134e-05 0.00048537171842897 1.36753438859108 0.5625 10.1 10 1 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 AXON GUIDANCE MEDIATED BY SLIT ROBO 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 OPIOID PROOPIOMELANOCORTIN PATHWAY 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 ENKEPHALIN RELEASE 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0212179680152373 0.0493408633791006 1.36753438859108 0.5625 10.1 10 1 FC EPSILON RI SIGNALING PATHWAY%KEGG%HSA04664 FC EPSILON RI SIGNALING PATHWAY 1.29252110989408e-06 1.37434603499624e-05 1.36545290550342 0.561643835616438 10.1 10 1 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 INTEGRIN SIGNALLING PATHWAY 2.05816124044832e-12 1.42825557659532e-10 1.36459345442207 0.561290322580645 10.1 10 1 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 KINASE PATHWAY 0.000279653017924344 0.00140198670773098 1.36382833333744 0.560975609756098 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000279653017924344 0.00140198670773098 1.36382833333744 0.560975609756098 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000279653017924344 0.00140198670773098 1.36382833333744 0.560975609756098 10.1 10 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.41395845536932e-09 1.06541854080663e-07 1.36327415685092 0.560747663551402 10.1 10 1 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) 6.52863895318736e-05 0.000419068202780197 1.36145645797512 0.56 10.1 10 1 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00448437720454103 0.0137984862174734 1.36145645797512 0.56 10.1 10 1 EGFR1%IOB%EGFR1 EGFR1 4.02017964864958e-32 2.65030343337224e-29 1.35859625533231 0.558823529411765 10.1 10 1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT 0.00100067017962831 0.00404718905472369 1.35859625533231 0.558823529411765 10.1 10 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00100067017962831 0.00404718905472369 1.35859625533231 0.558823529411765 10.1 10 1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) 8.87180074528131e-07 9.82980611987681e-06 1.35766761811062 0.558441558441558 10.1 10 1 PROTEASOME%KEGG%HSA03050 PROTEASOME 0.000229956642942268 0.00117975810785751 1.35693334681906 0.558139534883721 10.1 10 1 LEPTIN%NETPATH%LEPTIN LEPTIN 5.20870556835459e-08 8.27431119503075e-07 1.35633820061431 0.557894736842105 10.1 10 1 EGFR1%NETPATH%EGFR1 EGFR1 1.58167840753952e-32 2.06873240098338e-29 1.35543231435576 0.557522123893805 10.1 10 1 INFLUENZA A%KEGG%HSA05164 INFLUENZA A 4.5672348934719e-11 1.64983539918978e-09 1.35451025155688 0.557142857142857 10.1 10 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.77720446785382e-07 2.46657272722659e-06 1.35372090991844 0.556818181818182 10.1 10 1 TSLP%NETPATH%TSLP TSLP 7.73903196178474e-12 3.34554545626661e-10 1.35065124799119 0.555555555555556 10.1 10 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.57773710942904e-08 6.00923105577349e-07 1.35065124799119 0.555555555555556 10.1 10 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 1.47169213715003e-07 2.09775792738629e-06 1.35065124799119 0.555555555555556 10.1 10 1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION 2.52168509107407e-06 2.52839680044195e-05 1.35065124799119 0.555555555555556 10.1 10 1 SIG_BCR_SIGNALING_PATHWAY%MSIGDB_C2%SIG_BCR_SIGNALING_PATHWAY SIG_BCR_SIGNALING_PATHWAY 0.000188984112525821 0.000994712783893391 1.35065124799119 0.555555555555556 10.1 10 1 BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY 0.000819113414086754 0.0033908980736998 1.35065124799119 0.555555555555556 10.1 10 1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY 0.000819113414086754 0.0033908980736998 1.35065124799119 0.555555555555556 10.1 10 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000819113414086754 0.0033908980736998 1.35065124799119 0.555555555555556 10.1 10 1 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-PHOSPHOINOSITIDE DEGRADATION 0.0170210575088552 0.0407300622965981 1.35065124799119 0.555555555555556 10.1 10 1 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS 0.0170210575088552 0.0407300622965981 1.35065124799119 0.555555555555556 10.1 10 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0170210575088552 0.0407300622965981 1.35065124799119 0.555555555555556 10.1 10 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0170210575088552 0.0407300622965981 1.35065124799119 0.555555555555556 10.1 10 1 TRYPTOPHAN DEGRADATION%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 TRYPTOPHAN DEGRADATION 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 HEME BIOSYNTHESIS%HUMANCYC%PWY-5920 HEME BIOSYNTHESIS 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 CIRCADIAN CLOCK SYSTEM 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 CHOLESTEROL BIOSYNTHESIS 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0886400877093631 0.155311568963183 1.35065124799119 0.555555555555556 10.1 10 1 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 PATHWAY 0.00364627593370696 0.0115846140207051 1.35065124799119 0.555555555555556 10.1 10 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00364627593370696 0.0115846140207051 1.35065124799119 0.555555555555556 10.1 10 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000670243992198006 0.00286455981754642 1.34354255721229 0.552631578947368 10.1 10 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000670243992198006 0.00286455981754642 1.34354255721229 0.552631578947368 10.1 10 1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF RECEPTOR SIGNALING PATHWAY 2.03086218533097e-08 3.57025572181184e-07 1.34293324085981 0.552380952380952 10.1 10 1 RAS PATHWAY%PANTHER PATHWAY%P04393 RAS PATHWAY 7.1660125243667e-06 6.49373712259621e-05 1.34258765845094 0.552238805970149 10.1 10 1 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY 0.00296465555354895 0.00997167945753645 1.34133641179815 0.551724137931034 10.1 10 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.43424782859814e-07 4.43927035490848e-06 1.34133641179815 0.551724137931034 10.1 10 1 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY 0.013671264742997 0.0335047631294453 1.33714473551128 0.55 10.1 10 1 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY 0.013671264742997 0.0335047631294453 1.33714473551128 0.55 10.1 10 1 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY 0.013671264742997 0.0335047631294453 1.33714473551128 0.55 10.1 10 1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN REGULATION OF RETINOBLASTOMA PROTEIN 2.47447010099077e-05 0.000182778085610999 1.33714473551128 0.55 10.1 10 1 ENDOMETRIAL CANCER%KEGG%HSA05213 ENDOMETRIAL CANCER 0.000104635016494782 0.000625674690468801 1.33476123330894 0.549019607843137 10.1 10 1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B CELL ACTIVATION 0.000104635016494782 0.000625674690468801 1.33476123330894 0.549019607843137 10.1 10 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000104635016494782 0.000625674690468801 1.33476123330894 0.549019607843137 10.1 10 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.03565887014734e-05 0.000152935397167479 1.33322348995259 0.548387096774194 10.1 10 1 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY 0.00241060988218017 0.00830206836603441 1.33322348995259 0.548387096774194 10.1 10 1 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY%MSIGDB_C2%ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0.00241060988218017 0.00830206836603441 1.33322348995259 0.548387096774194 10.1 10 1 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF RECEPTOR (ERBB1) SIGNALING PATHWAY 0.00241060988218017 0.00830206836603441 1.33322348995259 0.548387096774194 10.1 10 1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY 7.97756300902876e-07 9.02868397202096e-06 1.33135623016274 0.547619047619048 10.1 10 1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING PRESENILIN ACTION IN NOTCH AND WNT SIGNALING 0.000448423180796536 0.00206235323237208 1.33135623016274 0.547619047619048 10.1 10 1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES 0.000448423180796536 0.00206235323237208 1.33135623016274 0.547619047619048 10.1 10 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000448423180796536 0.00206235323237208 1.33135623016274 0.547619047619048 10.1 10 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.59704695593181e-07 2.25209241860545e-06 1.33074691381027 0.547368421052632 10.1 10 1 ACUTE MYELOID LEUKEMIA%KEGG%HSA05221 ACUTE MYELOID LEUKEMIA 8.58678818684202e-05 0.000522941349854559 1.33026405934227 0.547169811320755 10.1 10 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.67419630723521e-05 0.000129848695946448 1.32954732224133 0.546875 10.1 10 1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK P73 TRANSCRIPTION FACTOR NETWORK 3.30423119779931e-06 3.22713246985066e-05 1.32904082802333 0.546666666666667 10.1 10 1 PHAGOSOME%KEGG%HSA04145 PHAGOSOME 1.08646446153627e-09 2.55804177238495e-08 1.32779407302518 0.546153846153846 10.1 10 1 RENAL CELL CARCINOMA%KEGG%HSA05211 RENAL CELL CARCINOMA 1.37657993392862e-05 0.000110001251083932 1.32609395257317 0.545454545454545 10.1 10 1 NOTCH SIGNALING PATHWAY%KEGG%HSA04330 NOTCH SIGNALING PATHWAY 0.000366704405646974 0.00173605078228444 1.32609395257317 0.545454545454545 10.1 10 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000366704405646974 0.00173605078228444 1.32609395257317 0.545454545454545 10.1 10 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000366704405646974 0.00173605078228444 1.32609395257317 0.545454545454545 10.1 10 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00196038476650418 0.00697642999901691 1.32609395257317 0.545454545454545 10.1 10 1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS 0.0109941979495617 0.0277432535818126 1.32609395257317 0.545454545454545 10.1 10 1 CIRCADIAN RHYTHM - MAMMAL%KEGG%HSA04710 CIRCADIAN RHYTHM - MAMMAL 0.0109941979495617 0.0277432535818126 1.32609395257317 0.545454545454545 10.1 10 1 REGULATION OF AUTOPHAGY%KEGG%HSA04140 REGULATION OF AUTOPHAGY 0.0109941979495617 0.0277432535818126 1.32609395257317 0.545454545454545 10.1 10 1 BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY 0.0109941979495617 0.0277432535818126 1.32609395257317 0.545454545454545 10.1 10 1 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY 0.0109941979495617 0.0277432535818126 1.32609395257317 0.545454545454545 10.1 10 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0109941979495617 0.0277432535818126 1.32609395257317 0.545454545454545 10.1 10 1 FOLATE TRANSFORMATIONS%HUMANCYC%PWY-2201 FOLATE TRANSFORMATIONS 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%HUMANCYC%PWY-7224 PURINE DEOXYRIBONUCLEOSIDES SALVAGE 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 BIOCARTA_GLYCOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_GLYCOLYSIS_PATHWAY BIOCARTA_GLYCOLYSIS_PATHWAY 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0688996153074993 0.129240882836225 1.32609395257317 0.545454545454545 10.1 10 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.19040004578623e-08 3.82522180181344e-07 1.32609395257317 0.545454545454545 10.1 10 1 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF RECEPTOR SIGNALING PATHWAY 0.000299852744867849 0.00148351161016232 1.32128926433921 0.543478260869565 10.1 10 1 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY 0.00159455552701665 0.00586449501358841 1.31977921946568 0.542857142857143 10.1 10 1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ERBB4 SIGNALING EVENTS 0.00159455552701665 0.00586449501358841 1.31977921946568 0.542857142857143 10.1 10 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00159455552701665 0.00586449501358841 1.31977921946568 0.542857142857143 10.1 10 1 INSULIN SIGNALING PATHWAY%KEGG%HSA04910 INSULIN SIGNALING PATHWAY 2.05671111670414e-09 4.63551043995624e-08 1.31924075385186 0.542635658914729 10.1 10 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.4633096515517e-15 3.80531147964243e-13 1.31915624131157 0.542600896860987 10.1 10 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000245177345464294 0.00124603541198814 1.31688496679141 0.541666666666667 10.1 10 1 IL9%NETPATH%IL9 IL9 0.00885171292936066 0.0233609131972072 1.31688496679141 0.541666666666667 10.1 10 1 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 ADRENALINE AND NORADRENALINE BIOSYNTHESIS 0.00885171292936066 0.0233609131972072 1.31688496679141 0.541666666666667 10.1 10 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00885171292936066 0.0233609131972072 1.31688496679141 0.541666666666667 10.1 10 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00885171292936066 0.0233609131972072 1.31688496679141 0.541666666666667 10.1 10 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00885171292936066 0.0233609131972072 1.31688496679141 0.541666666666667 10.1 10 1 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 7.64312603473968e-06 6.85541610666957e-05 1.31688496679141 0.541666666666667 10.1 10 1 PYRUVATE METABOLISM%KEGG%HSA00620 PYRUVATE METABOLISM 0.00129728764153169 0.00497419817724688 1.31414716020764 0.540540540540541 10.1 10 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00129728764153169 0.00497419817724688 1.31414716020764 0.540540540540541 10.1 10 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00129728764153169 0.00497419817724688 1.31414716020764 0.540540540540541 10.1 10 1 FAS%IOB%FAS FAS 3.415058224964e-08 5.77276188412184e-07 1.31414716020764 0.540540540540541 10.1 10 1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY 0.000200468477740958 0.00103653995255472 1.31283301304744 0.54 10.1 10 1 LONG-TERM DEPRESSION%KEGG%HSA04730 LONG-TERM DEPRESSION 3.18767407003135e-05 0.000225359156103825 1.3120612123343 0.53968253968254 10.1 10 1 UBIQUITIN MEDIATED PROTEOLYSIS%KEGG%HSA04120 UBIQUITIN MEDIATED PROTEOLYSIS 3.86896862174381e-09 7.90889167096001e-08 1.31055378906645 0.5390625 10.1 10 1 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM%KEGG%HSA04141 PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM 8.96848059409201e-11 3.07141341904164e-09 1.309092748053 0.538461538461538 10.1 10 1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK 2.61373850983133e-05 0.000190925995856654 1.309092748053 0.538461538461538 10.1 10 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.61373850983133e-05 0.000190925995856654 1.309092748053 0.538461538461538 10.1 10 1 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY 0.00713459506660116 0.0197687042782403 1.309092748053 0.538461538461538 10.1 10 1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING EPHRIN B REVERSE SIGNALING 0.00713459506660116 0.0197687042782403 1.309092748053 0.538461538461538 10.1 10 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00713459506660116 0.0197687042782403 1.309092748053 0.538461538461538 10.1 10 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00713459506660116 0.0197687042782403 1.309092748053 0.538461538461538 10.1 10 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00713459506660116 0.0197687042782403 1.309092748053 0.538461538461538 10.1 10 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00713459506660116 0.0197687042782403 1.309092748053 0.538461538461538 10.1 10 1 TERPENOID BACKBONE BIOSYNTHESIS%KEGG%HSA00900 TERPENOID BACKBONE BIOSYNTHESIS 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0539529564166137 0.105232208632108 1.309092748053 0.538461538461538 10.1 10 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.64457298189913e-28 2.9769477906536e-25 1.30825412361478 0.538116591928251 10.1 10 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.96271819299124e-14 5.2412292916393e-12 1.30820220876861 0.538095238095238 10.1 10 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.14300678985478e-05 0.000160542866614973 1.30630150551984 0.537313432835821 10.1 10 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000134028379125143 0.000773376008212261 1.30562953972482 0.537037037037037 10.1 10 1 ENDOCRINE AND OTHER FACTOR-REGULATED CALCIUM REABSORPTION%KEGG%HSA04961 ENDOCRINE AND OTHER FACTOR-REGULATED CALCIUM REABSORPTION 0.000859322498775687 0.0035406772332367 1.3045314492793 0.536585365853659 10.1 10 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000859322498775687 0.0035406772332367 1.3045314492793 0.536585365853659 10.1 10 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.02581906896289e-17 1.08186749476614e-14 1.30407706702598 0.53639846743295 10.1 10 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.75696933813742e-05 0.000135868860547459 1.30367207414802 0.536231884057971 10.1 10 1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY 0.000109596344897408 0.000649450699987559 1.30241370342008 0.535714285714286 10.1 10 1 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY 0.000109596344897408 0.000649450699987559 1.30241370342008 0.535714285714286 10.1 10 1 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY 0.0057564801940675 0.0166081381529059 1.30241370342008 0.535714285714286 10.1 10 1 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE 0.0057564801940675 0.0166081381529059 1.30241370342008 0.535714285714286 10.1 10 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0057564801940675 0.0166081381529059 1.30241370342008 0.535714285714286 10.1 10 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0057564801940675 0.0166081381529059 1.30241370342008 0.535714285714286 10.1 10 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0057564801940675 0.0166081381529059 1.30241370342008 0.535714285714286 10.1 10 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0057564801940675 0.0166081381529059 1.30241370342008 0.535714285714286 10.1 10 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.44042011411495e-05 0.000114754919665291 1.30119077975489 0.535211267605634 10.1 10 1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY REGULATION OF RHOA ACTIVITY 0.000699659699328944 0.00296208348788444 1.30039445736826 0.534883720930233 10.1 10 1 GLUTATHIONE METABOLISM%KEGG%HSA00480 GLUTATHIONE METABOLISM 0.000569813312071153 0.00248774454293317 1.29662519807154 0.533333333333333 10.1 10 1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR SIGNALING PATHWAY 7.32938538229662e-05 0.000457480234416513 1.29662519807154 0.533333333333333 10.1 10 1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING AMB2 INTEGRIN SIGNALING 0.00464898719261239 0.0142220176646391 1.29662519807154 0.533333333333333 10.1 10 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.00464898719261239 0.0142220176646391 1.29662519807154 0.533333333333333 10.1 10 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00464898719261239 0.0142220176646391 1.29662519807154 0.533333333333333 10.1 10 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00464898719261239 0.0142220176646391 1.29662519807154 0.533333333333333 10.1 10 1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%HUMANCYC%PWY-7200 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE 0.0424892834704876 0.086320678360305 1.29662519807154 0.533333333333333 10.1 10 1 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY 0.0424892834704876 0.086320678360305 1.29662519807154 0.533333333333333 10.1 10 1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.0424892834704876 0.086320678360305 1.29662519807154 0.533333333333333 10.1 10 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0424892834704876 0.086320678360305 1.29662519807154 0.533333333333333 10.1 10 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0424892834704876 0.086320678360305 1.29662519807154 0.533333333333333 10.1 10 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0424892834704876 0.086320678360305 1.29662519807154 0.533333333333333 10.1 10 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000464186489774713 0.00210394669617911 1.29317672680008 0.531914893617021 10.1 10 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.902948867867e-05 0.000328984126324816 1.29156025589157 0.53125 10.1 10 1 ST_ADRENERGIC%MSIGDB_C2%ST_ADRENERGIC ST_ADRENERGIC 0.00375788059760731 0.0118677019591503 1.29156025589157 0.53125 10.1 10 1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS SYNDECAN-4-MEDIATED SIGNALING EVENTS 0.00375788059760731 0.0118677019591503 1.29156025589157 0.53125 10.1 10 1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY 0.00375788059760731 0.0118677019591503 1.29156025589157 0.53125 10.1 10 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00375788059760731 0.0118677019591503 1.29156025589157 0.53125 10.1 10 1 HYPERTROPHIC CARDIOMYOPATHY (HCM)%KEGG%HSA05410 HYPERTROPHIC CARDIOMYOPATHY (HCM) 5.33349085690743e-06 4.88347756585586e-05 1.29062230363603 0.530864197530864 10.1 10 1 AMOEBIASIS%KEGG%HSA05146 AMOEBIASIS 5.90549117841139e-07 6.98330952352952e-06 1.2900097633875 0.530612244897959 10.1 10 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000378237653258305 0.00178109409221812 1.2900097633875 0.530612244897959 10.1 10 1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 4.01053045036663e-05 0.000276129733619238 1.28925800944614 0.53030303030303 10.1 10 1 TOXOPLASMOSIS%KEGG%HSA05145 TOXOPLASMOSIS 5.43494505908509e-08 8.5820060603637e-07 1.2883134980839 0.52991452991453 10.1 10 1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY 3.97978816645387e-07 4.95033084666927e-06 1.28709118926219 0.529411764705882 10.1 10 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00304006367673956 0.010122030196417 1.28709118926219 0.529411764705882 10.1 10 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00304006367673956 0.010122030196417 1.28709118926219 0.529411764705882 10.1 10 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00304006367673956 0.010122030196417 1.28709118926219 0.529411764705882 10.1 10 1 SELENOCOMPOUND METABOLISM%KEGG%HSA00450 SELENOCOMPOUND METABOLISM 0.0336126433356583 0.0711368703660763 1.28709118926219 0.529411764705882 10.1 10 1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY 0.0336126433356583 0.0711368703660763 1.28709118926219 0.529411764705882 10.1 10 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0336126433356583 0.0711368703660763 1.28709118926219 0.529411764705882 10.1 10 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0336126433356583 0.0711368703660763 1.28709118926219 0.529411764705882 10.1 10 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0336126433356583 0.0711368703660763 1.28709118926219 0.529411764705882 10.1 10 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0336126433356583 0.0711368703660763 1.28709118926219 0.529411764705882 10.1 10 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00246122612382065 0.0084398612334396 1.28311868559163 0.527777777777778 10.1 10 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.47046724663111e-05 0.000116445108989977 1.27956434020218 0.526315789473684 10.1 10 1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING 0.000167156320753684 0.000894606834314943 1.27956434020218 0.526315789473684 10.1 10 1 CDP-DIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%PWY-5667 CDP-DIACYLGLYCEROL BIOSYNTHESIS 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 PROXIMAL TUBULE BICARBONATE RECLAMATION%KEGG%HSA04964 PROXIMAL TUBULE BICARBONATE RECLAMATION 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY ARF1 PATHWAY 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0266884724087055 0.0589426312745028 1.27956434020218 0.526315789473684 10.1 10 1 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-MEDIATED SIGNALING EVENTS 0.000136368345700062 0.000785160103954287 1.27739558708319 0.525423728813559 10.1 10 1 SYSTEMIC LUPUS ERYTHEMATOSUS%KEGG%HSA05322 SYSTEMIC LUPUS ERYTHEMATOSUS 8.92445127308644e-07 9.84676904063972e-06 1.27697936173712 0.525252525252525 10.1 10 1 LYSINE DEGRADATION%KEGG%HSA00310 LYSINE DEGRADATION 0.00161653014218253 0.00592054164574351 1.27636542935167 0.525 10.1 10 1 BASAL TRANSCRIPTION FACTORS%KEGG%HSA03022 BASAL TRANSCRIPTION FACTORS 0.00161653014218253 0.00592054164574351 1.27636542935167 0.525 10.1 10 1 UNTITLED%PANTHER PATHWAY%P00019 UNTITLED 0.000111275121201242 0.000654983246892131 1.27536904728348 0.524590163934426 10.1 10 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000111275121201242 0.000654983246892131 1.27536904728348 0.524590163934426 10.1 10 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000111275121201242 0.000654983246892131 1.27536904728348 0.524590163934426 10.1 10 1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS CLASS I PI3K SIGNALING EVENTS 0.00131131174855275 0.00500423890149581 1.27347117667741 0.523809523809524 10.1 10 1 GLYCOSAMINOGLYCAN BIOSYNTHESIS - CHONDROITIN SULFATE%KEGG%HSA00532 GLYCOSAMINOGLYCAN BIOSYNTHESIS - CHONDROITIN SULFATE 0.0212556772084408 0.0493408633791006 1.27347117667741 0.523809523809524 10.1 10 1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY 0.0212556772084408 0.0493408633791006 1.27347117667741 0.523809523809524 10.1 10 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0212556772084408 0.0493408633791006 1.27347117667741 0.523809523809524 10.1 10 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 9.08182060235445e-05 0.00055054622823928 1.27347117667741 0.523809523809524 10.1 10 1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS 0.00106432502098063 0.00425251421676142 1.27084003788262 0.522727272727273 10.1 10 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.6215384188948e-06 3.44765227820418e-05 1.26961217311172 0.522222222222222 10.1 10 1 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS 0.000864315749020213 0.00354517218303617 1.26843769376564 0.521739130434783 10.1 10 1 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY 0.0169727460682974 0.0407300622965981 1.26843769376564 0.521739130434783 10.1 10 1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT 0.0169727460682974 0.0407300622965981 1.26843769376564 0.521739130434783 10.1 10 1 CHEMOKINE SIGNALING PATHWAY%KEGG%HSA04062 CHEMOKINE SIGNALING PATHWAY 4.83924998231438e-10 1.2510884513101e-08 1.26715644356992 0.521212121212121 10.1 10 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.07042880870035e-11 8.27696524479943e-10 1.26623554499174 0.520833333333333 10.1 10 1 AXON GUIDANCE%KEGG%HSA04360 AXON GUIDANCE 6.76870444256907e-08 1.03773683808457e-06 1.26420956811975 0.52 10.1 10 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000570820926735435 0.00248802443603528 1.26420956811975 0.52 10.1 10 1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY REELIN SIGNALING PATHWAY 0.0135829932979153 0.0333815035662652 1.26420956811975 0.52 10.1 10 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0135829932979153 0.0333815035662652 1.26420956811975 0.52 10.1 10 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0135829932979153 0.0333815035662652 1.26420956811975 0.52 10.1 10 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0135829932979153 0.0333815035662652 1.26420956811975 0.52 10.1 10 1 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR SIGNALING IN NAIVE CD8+ T CELLS 0.000464197817440608 0.00210394669617911 1.26233943562253 0.519230769230769 10.1 10 1 CHOLINERGIC SYNAPSE%KEGG%HSA04725 CHOLINERGIC SYNAPSE 7.33311525720035e-07 8.44429036385909e-06 1.26145729765215 0.518867924528302 10.1 10 1 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-PHOSPHOINOSITIDE BIOSYNTHESIS 0.0108912464404872 0.0276688023733766 1.26060783145844 0.518518518518518 10.1 10 1 PENTOSE PHOSPHATE PATHWAY%KEGG%HSA00030 PENTOSE PHOSPHATE PATHWAY 0.0108912464404872 0.0276688023733766 1.26060783145844 0.518518518518518 10.1 10 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000307348552475048 0.00151774931250319 1.25899991330607 0.517857142857143 10.1 10 1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-MEDIATED SIGNALING EVENTS 0.000250227975164029 0.00126650896450584 1.25750288606076 0.517241379310345 10.1 10 1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY 0.00874772088033742 0.0232537701224292 1.25750288606076 0.517241379310345 10.1 10 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00874772088033742 0.0232537701224292 1.25750288606076 0.517241379310345 10.1 10 1 CELL CYCLE%KEGG%HSA04110 CELL CYCLE 2.21918298658108e-07 3.04790913313245e-06 1.25679243245282 0.516949152542373 10.1 10 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000203792802534198 0.00105144840082662 1.25610566063181 0.516666666666667 10.1 10 1 NATURAL KILLER CELL MEDIATED CYTOTOXICITY%KEGG%HSA04650 NATURAL KILLER CELL MEDIATED CYTOTOXICITY 4.40135539417084e-06 4.05817278826171e-05 1.25479857877891 0.516129032258065 10.1 10 1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS INTEGRINS IN ANGIOGENESIS 0.000166028204999954 0.000894606834314943 1.25479857877891 0.516129032258065 10.1 10 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00703658965707343 0.0196562361501087 1.25479857877891 0.516129032258065 10.1 10 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00703658965707343 0.0196562361501087 1.25479857877891 0.516129032258065 10.1 10 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00703658965707343 0.0196562361501087 1.25479857877891 0.516129032258065 10.1 10 1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA FORWARD SIGNALING 0.00566771991815435 0.016471158289897 1.2524220663191 0.515151515151515 10.1 10 1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK 0.00566771991815435 0.016471158289897 1.2524220663191 0.515151515151515 10.1 10 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 8.6807103191785e-10 2.15039010351583e-08 1.25155020967704 0.514792899408284 10.1 10 1 ADIPOCYTOKINE SIGNALING PATHWAY%KEGG%HSA04920 ADIPOCYTOKINE SIGNALING PATHWAY 7.33516739861148e-05 0.000457480234416513 1.25031715528327 0.514285714285714 10.1 10 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 7.33516739861148e-05 0.000457480234416513 1.25031715528327 0.514285714285714 10.1 10 1 CYSTEINE AND METHIONINE METABOLISM%KEGG%HSA00270 CYSTEINE AND METHIONINE METABOLISM 0.00457060171762265 0.0140474087754906 1.25031715528327 0.514285714285714 10.1 10 1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F TRANSCRIPTION FACTOR NETWORK 5.98410646077101e-05 0.000390596255867652 1.24935240439185 0.513888888888889 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.98410646077101e-05 0.000390596255867652 1.24935240439185 0.513888888888889 10.1 10 1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC)%KEGG%HSA05412 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC) 4.88303997989923e-05 0.000328484092525364 1.24843980219726 0.513513513513513 10.1 10 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.98545560522269e-05 0.000276129733619238 1.24757523169712 0.513157894736842 10.1 10 1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 TRANSCRIPTION FACTOR NETWORK 0.00298169103093581 0.00999074872754475 1.24675499814571 0.512820512820513 10.1 10 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00298169103093581 0.00999074872754475 1.24675499814571 0.512820512820513 10.1 10 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00298169103093581 0.00999074872754475 1.24675499814571 0.512820512820513 10.1 10 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.42479791465897e-09 7.11117488264228e-08 1.24597577627187 0.5125 10.1 10 1 REGULATION OF ACTIN CYTOSKELETON%KEGG%HSA04810 REGULATION OF ACTIN CYTOSKELETON 3.66645637079494e-11 1.34283964580365e-09 1.24582458396799 0.512437810945274 10.1 10 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.67242218164188e-07 3.57724735684753e-06 1.24572462211419 0.512396694214876 10.1 10 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.67242218164188e-07 3.57724735684753e-06 1.24572462211419 0.512396694214876 10.1 10 1 TGF-BETA SIGNALING PATHWAY%KEGG%HSA04350 TGF-BETA SIGNALING PATHWAY 2.16958388626718e-05 0.000162073447821149 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00241159816775971 0.00830206836603441 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00241159816775971 0.00830206836603441 1.24523456522115 0.51219512195122 10.1 10 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00241159816775971 0.00830206836603441 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00241159816775971 0.00830206836603441 1.24523456522115 0.51219512195122 10.1 10 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00241159816775971 0.00830206836603441 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00241159816775971 0.00830206836603441 1.24523456522115 0.51219512195122 10.1 10 1 PROSTATE CANCER%KEGG%HSA05215 PROSTATE CANCER 1.77217840578028e-05 0.00013624590250853 1.24452864993474 0.511904761904762 10.1 10 1 ERBB SIGNALING PATHWAY%KEGG%HSA04012 ERBB SIGNALING PATHWAY 1.77217840578028e-05 0.00013624590250853 1.24452864993474 0.511904761904762 10.1 10 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.27101888801409e-09 2.94006737516944e-08 1.24418814962012 0.511764705882353 10.1 10 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.20356176677912e-07 1.74384196648162e-06 1.24385556791747 0.511627906976744 10.1 10 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.44782025718837e-05 0.000114997048741136 1.24385556791747 0.511627906976744 10.1 10 1 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION%KEGG%HSA00280 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION 0.00195209008583484 0.00696571252550267 1.24385556791747 0.511627906976744 10.1 10 1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 TOLL RECEPTOR SIGNALING PATHWAY 0.00195209008583484 0.00696571252550267 1.24385556791747 0.511627906976744 10.1 10 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00195209008583484 0.00696571252550267 1.24385556791747 0.511627906976744 10.1 10 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.3422791808096e-26 4.42448774974365e-24 1.24331812600254 0.511406844106464 10.1 10 1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF SIGNALING PATHWAY 0.00158131453484053 0.00584023309296144 1.24259914815189 0.511111111111111 10.1 10 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.5321290593481e-06 3.39793567505432e-05 1.23989784565591 0.51 10.1 10 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.88550777613274e-21 3.55148857547289e-19 1.23841403160882 0.509389671361502 10.1 10 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.0923339073737e-09 8.23777443797286e-08 1.23795887392567 0.50920245398773 10.1 10 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000556745196249105 0.00243472152986549 1.23768768906829 0.509090909090909 10.1 10 1 SPLICEOSOME%KEGG%HSA03040 SPLICEOSOME 1.05931680677247e-06 1.14017078345266e-05 1.23729301824907 0.508928571428571 10.1 10 1 MEASLES%KEGG%HSA05162 MEASLES 8.6699259166983e-07 9.64666440604786e-06 1.23691219552877 0.508771929824561 10.1 10 1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY NOTCH SIGNALING PATHWAY 0.000452547649615028 0.00206465078206718 1.23691219552877 0.508771929824561 10.1 10 1 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY COREGULATION OF ANDROGEN RECEPTOR ACTIVITY 0.000452547649615028 0.00206465078206718 1.23691219552877 0.508771929824561 10.1 10 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.10698851647043e-15 4.33205148717301e-13 1.23632991369023 0.508532423208191 10.1 10 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000368013798747441 0.00173605078228444 1.23618927782244 0.508474576271186 10.1 10 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000368013798747441 0.00173605078228444 1.23618927782244 0.508474576271186 10.1 10 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000299394406578254 0.00148351161016232 1.23551376455587 0.508196721311475 10.1 10 1 RNA TRANSPORT%KEGG%HSA03013 RNA TRANSPORT 1.43407379598995e-07 2.05524597827473e-06 1.23400409475559 0.507575757575758 10.1 10 1 JAK-STAT SIGNALING PATHWAY%KEGG%HSA04630 JAK-STAT SIGNALING PATHWAY 1.1746373093351e-07 1.71133623465008e-06 1.23372919965762 0.507462686567164 10.1 10 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000131629051405664 0.000761196948589331 1.23320331338326 0.507246376811594 10.1 10 1 ST_INTEGRIN_SIGNALING_PATHWAY%MSIGDB_C2%ST_INTEGRIN_SIGNALING_PATHWAY ST_INTEGRIN_SIGNALING_PATHWAY 5.81564156322192e-05 0.000383396170055405 1.2313729559608 0.506493506493506 10.1 10 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.87156260067406e-05 0.000270087581427976 1.23059335928086 0.506172839506173 10.1 10 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.77645514796481e-24 1.78695122251832e-21 1.23041034420661 0.50609756097561 10.1 10 1 DILATED CARDIOMYOPATHY%KEGG%HSA05414 DILATED CARDIOMYOPATHY 2.57965094080814e-05 0.000189485780805322 1.22988713640609 0.505882352941176 10.1 10 1 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF SIGNALING PATHWAY 9.38011921436515e-06 8.05712520139443e-05 1.22838176659409 0.505263157894737 10.1 10 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.28937359585885e-11 9.01056443623849e-10 1.22663690613018 0.504545454545455 10.1 10 1 HEPATITIS C%KEGG%HSA05160 HEPATITIS C 8.39875845476742e-07 9.42447916817944e-06 1.22580113263066 0.504201680672269 10.1 10 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.32647926825005e-13 1.12836317108884e-11 1.22452425645084 0.503676470588235 10.1 10 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.13682082087219e-07 1.67474665063685e-06 1.22433134709993 0.503597122302158 10.1 10 1 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY 3.15484396930842e-09 6.65545883765304e-08 1.22253232961031 0.502857142857143 10.1 10 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.62095151007044e-07 4.59060054425757e-06 1.21558612319207 0.5 10.1 10 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000654867324066028 0.00281251650417283 1.21558612319207 0.5 10.1 10 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00150866358461544 0.00564304379096584 1.21558612319207 0.5 10.1 10 1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 TRANSCRIPTION FACTOR NETWORK 0.00434685191968908 0.0135172741889388 1.21558612319207 0.5 10.1 10 1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR 0.00434685191968908 0.0135172741889388 1.21558612319207 0.5 10.1 10 1 MISMATCH REPAIR%KEGG%HSA03430 MISMATCH REPAIR 0.0315171564673199 0.0676797570067774 1.21558612319207 0.5 10.1 10 1 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES 0.0315171564673199 0.0676797570067774 1.21558612319207 0.5 10.1 10 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0315171564673199 0.0676797570067774 1.21558612319207 0.5 10.1 10 1 NGF%IOB%NGF NGF 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0397056800744139 0.0824439987056925 1.21558612319207 0.5 10.1 10 1 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE) 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%HUMANCYC%PWY-7197 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 PURINE NUCLEOTIDES DEGRADATION%HUMANCYC%PWY-6353 PURINE NUCLEOTIDES DEGRADATION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION%HUMANCYC%PWY-7434 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 SULFUR METABOLISM%KEGG%HSA00920 SULFUR METABOLISM 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 ST_G_ALPHA_S_PATHWAY%MSIGDB_C2%ST_G_ALPHA_S_PATHWAY ST_G_ALPHA_S_PATHWAY 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 HEME BIOSYNTHESIS 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.13595304749995 0.221164828042793 1.21558612319207 0.5 10.1 10 1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-BETA SIGNALING PATHWAY 4.54768582938036e-05 0.000309877197211266 1.21558612319207 0.5 10.1 10 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000154700497145744 0.000842862006143237 1.21558612319207 0.5 10.1 10 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000806141840023162 0.00337964393027198 1.21558612319207 0.5 10.1 10 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000992870621260238 0.00402799973578961 1.21558612319207 0.5 10.1 10 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00186144395765804 0.00666933113633729 1.21558612319207 0.5 10.1 10 1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY 0.00229831332066086 0.00802735394249361 1.21558612319207 0.5 10.1 10 1 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 SIGNALING EVENTS 0.00351188458696666 0.0112116702855098 1.21558612319207 0.5 10.1 10 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00351188458696666 0.0112116702855098 1.21558612319207 0.5 10.1 10 1 TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY TRNA CHARGING 0.00538565290279328 0.0160588274079476 1.21558612319207 0.5 10.1 10 1 HEDGEHOG%IOB%HEDGEHOG HEDGEHOG 0.00538565290279328 0.0160588274079476 1.21558612319207 0.5 10.1 10 1 HEDGEHOG%NETPATH%HEDGEHOG HEDGEHOG 0.00538565290279328 0.0160588274079476 1.21558612319207 0.5 10.1 10 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00538565290279328 0.0160588274079476 1.21558612319207 0.5 10.1 10 1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING AURORA B SIGNALING 0.00667997731142465 0.0189984870815523 1.21558612319207 0.5 10.1 10 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00667997731142465 0.0189984870815523 1.21558612319207 0.5 10.1 10 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.00667997731142465 0.0189984870815523 1.21558612319207 0.5 10.1 10 1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS SYNDECAN-2-MEDIATED SIGNALING EVENTS 0.00829537615956909 0.0222749775320167 1.21558612319207 0.5 10.1 10 1 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 NOTCH SIGNALING PATHWAY 0.00829537615956909 0.0222749775320167 1.21558612319207 0.5 10.1 10 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00829537615956909 0.0222749775320167 1.21558612319207 0.5 10.1 10 1 AFRICAN TRYPANOSOMIASIS%KEGG%HSA05143 AFRICAN TRYPANOSOMIASIS 0.0128464545680624 0.0316895235696732 1.21558612319207 0.5 10.1 10 1 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY 0.0128464545680624 0.0316895235696732 1.21558612319207 0.5 10.1 10 1 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 SIGNALING EVENTS MEDIATED BY STAT5 0.0128464545680624 0.0316895235696732 1.21558612319207 0.5 10.1 10 1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY 0.0128464545680624 0.0316895235696732 1.21558612319207 0.5 10.1 10 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0128464545680624 0.0316895235696732 1.21558612319207 0.5 10.1 10 1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY NECTIN ADHESION PATHWAY 0.016026012686907 0.0386294291182576 1.21558612319207 0.5 10.1 10 1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY REGULATION OF CDC42 ACTIVITY 0.016026012686907 0.0386294291182576 1.21558612319207 0.5 10.1 10 1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 SIGNALING EVENTS 0.0200313915292293 0.0471211235170185 1.21558612319207 0.5 10.1 10 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0200313915292293 0.0471211235170185 1.21558612319207 0.5 10.1 10 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0200313915292293 0.0471211235170185 1.21558612319207 0.5 10.1 10 1 TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY TRIACYLGLYCEROL BIOSYNTHESIS 0.0250937792072342 0.056461003216277 1.21558612319207 0.5 10.1 10 1 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 DE NOVO PURINE BIOSYNTHESIS 0.0250937792072342 0.056461003216277 1.21558612319207 0.5 10.1 10 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0250937792072342 0.056461003216277 1.21558612319207 0.5 10.1 10 1 CCR9%IOB%CCR9 CCR9 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 ONE CARBON POOL BY FOLATE%KEGG%HSA00670 ONE CARBON POOL BY FOLATE 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN DEGRADATION OF BETA CATENIN 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 UNTITLED%PANTHER PATHWAY%P05916 UNTITLED 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0502042291624615 0.100294357804099 1.21558612319207 0.5 10.1 10 1 RENIN-ANGIOTENSIN SYSTEM%KEGG%HSA04614 RENIN-ANGIOTENSIN SYSTEM 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 OPIOID PROENKEPHALIN PATHWAY 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.063760598925738 0.121604427475723 1.21558612319207 0.5 10.1 10 1 SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 SA_TRKA_RECEPTOR%MSIGDB_C2%SA_TRKA_RECEPTOR SA_TRKA_RECEPTOR 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK SIGNALING IN THE CD4+ TCR PATHWAY 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 GENERAL TRANSCRIPTION BY RNA POLYMERASE I 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0814252638090616 0.148183865192889 1.21558612319207 0.5 10.1 10 1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.104720894198504 0.179784503907197 1.21558612319207 0.5 10.1 10 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.53320751380305e-09 7.27895954210832e-08 1.2089435760708 0.497267759562842 10.1 10 1 PATHWAYS IN CANCER%KEGG%HSA05200 PATHWAYS IN CANCER 1.88399799540534e-14 1.71313886685651e-12 1.2077436320747 0.496774193548387 10.1 10 1 T CELL RECEPTOR SIGNALING PATHWAY%KEGG%HSA04660 T CELL RECEPTOR SIGNALING PATHWAY 1.04619362836626e-05 8.87078005788368e-05 1.20378431617079 0.495145631067961 10.1 10 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.46995246472997e-05 0.000419068202780197 1.20128510997805 0.494117647058824 10.1 10 1 RNA DEGRADATION%KEGG%HSA03018 RNA DEGRADATION 0.000331870664370124 0.00161763944906473 1.19796893300088 0.492753623188406 10.1 10 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000331870664370124 0.00161763944906473 1.19796893300088 0.492753623188406 10.1 10 1 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS BETA1 INTEGRIN CELL SURFACE INTERACTIONS 0.000407689211988571 0.00189942836044852 1.19744304672652 0.492537313432836 10.1 10 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.000407689211988571 0.00189942836044852 1.19744304672652 0.492537313432836 10.1 10 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.000407689211988571 0.00189942836044852 1.19744304672652 0.492537313432836 10.1 10 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.34463690938302e-42 1.4093807530043e-38 1.1973340793003 0.492492492492492 10.1 10 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.57512572475975e-09 1.62680622562529e-07 1.19565848182827 0.491803278688525 10.1 10 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000757564203072723 0.00318104586545027 1.19565848182827 0.491803278688525 10.1 10 1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T CELL ACTIVATION 0.00093215906520732 0.00380511370735557 1.1949829685617 0.491525423728814 10.1 10 1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS 0.00114754312731377 0.00455048304770891 1.19426005085537 0.491228070175439 10.1 10 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00141342013823528 0.00531695992086508 1.19348455731585 0.490909090909091 10.1 10 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00141342013823528 0.00531695992086508 1.19348455731585 0.490909090909091 10.1 10 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00141342013823528 0.00531695992086508 1.19348455731585 0.490909090909091 10.1 10 1 ENDOCYTOSIS%KEGG%HSA04144 ENDOCYTOSIS 8.07041663590778e-09 1.55340793203568e-07 1.18972258865607 0.48936170212766 10.1 10 1 BDNF%IOB%BDNF BDNF 0.00404367660932675 0.0126490809238371 1.18857309823225 0.488888888888889 10.1 10 1 MALARIA%KEGG%HSA05144 MALARIA 0.00404367660932675 0.0126490809238371 1.18857309823225 0.488888888888889 10.1 10 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.32485281472488e-22 7.9705789749359e-20 1.18826958109787 0.48876404494382 10.1 10 1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR ANDROGENRECEPTOR 2.26681063403813e-06 2.2922323340083e-05 1.18687149036076 0.488188976377953 10.1 10 1 AMINOACYL-TRNA BIOSYNTHESIS%KEGG%HSA00970 AMINOACYL-TRNA BIOSYNTHESIS 0.00618995073105037 0.01781975991024 1.185937681163 0.48780487804878 10.1 10 1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION 0.000205511291791148 0.00105640014903169 1.18441724823843 0.487179487179487 10.1 10 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.88225767032028e-07 3.80025673831729e-06 1.18359701468702 0.486842105263158 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00951275048055005 0.0248022487063142 1.18273244418688 0.486486486486487 10.1 10 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00951275048055005 0.0248022487063142 1.18273244418688 0.486486486486487 10.1 10 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00951275048055005 0.0248022487063142 1.18273244418688 0.486486486486487 10.1 10 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00037954704950563 0.0017840740990131 1.18181984199229 0.486111111111111 10.1 10 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.69258794680926e-08 6.12412227404781e-07 1.18124753214145 0.485875706214689 10.1 10 1 ANGIOGENESIS%PANTHER PATHWAY%P00005 ANGIOGENESIS 9.52073870580845e-07 1.03744578376929e-05 1.18085509110087 0.485714285714286 10.1 10 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 9.52073870580845e-07 1.03744578376929e-05 1.18085509110087 0.485714285714286 10.1 10 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.52073870580845e-07 1.03744578376929e-05 1.18085509110087 0.485714285714286 10.1 10 1 SALIVARY SECRETION%KEGG%HSA04970 SALIVARY SECRETION 0.000465947997940312 0.00210394669617911 1.18085509110087 0.485714285714286 10.1 10 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000465947997940312 0.00210394669617911 1.18085509110087 0.485714285714286 10.1 10 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000702944281400317 0.00297061549687923 1.17875018006504 0.484848484848485 10.1 10 1 SNARE INTERACTIONS IN VESICULAR TRANSPORT%KEGG%HSA04130 SNARE INTERACTIONS IN VESICULAR TRANSPORT 0.0146894905267845 0.0358005420694369 1.17875018006504 0.484848484848485 10.1 10 1 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY 0.0146894905267845 0.0358005420694369 1.17875018006504 0.484848484848485 10.1 10 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0146894905267845 0.0358005420694369 1.17875018006504 0.484848484848485 10.1 10 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0146894905267845 0.0358005420694369 1.17875018006504 0.484848484848485 10.1 10 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.60941236451292e-11 1.34056625425642e-09 1.1781834732477 0.484615384615385 10.1 10 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000863874284783678 0.00354517218303617 1.17759905684232 0.484375 10.1 10 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.2023118345504e-07 3.04057398309392e-06 1.17736014447534 0.484276729559748 10.1 10 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.68610484021183e-07 3.57740326446393e-06 1.17687318933245 0.484076433121019 10.1 10 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.27629948949863e-07 4.27703057119203e-06 1.17637366760523 0.483870967741935 10.1 10 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00106206757330662 0.00425251421676142 1.17637366760523 0.483870967741935 10.1 10 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0182932029221146 0.0433982917355097 1.17637366760523 0.483870967741935 10.1 10 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00130628176963159 0.00499943139899838 1.17506658575233 0.483333333333333 10.1 10 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00160737387701168 0.00590340517225597 1.17366936032338 0.482758620689655 10.1 10 1 PROPANOATE METABOLISM%KEGG%HSA00640 PROPANOATE METABOLISM 0.0228190850397053 0.0521890088895949 1.17366936032338 0.482758620689655 10.1 10 1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.0228190850397053 0.0521890088895949 1.17366936032338 0.482758620689655 10.1 10 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.60746197977445e-06 1.68209414312113e-05 1.17186000365279 0.482014388489209 10.1 10 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000190119343564313 0.000996709162980303 1.17164927536585 0.481927710843373 10.1 10 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000190119343564313 0.000996709162980303 1.17164927536585 0.481927710843373 10.1 10 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00243735010000927 0.0083688700699537 1.1705644149257 0.481481481481481 10.1 10 1 THYROID CANCER%KEGG%HSA05216 THYROID CANCER 0.0285186691116327 0.0618451730652758 1.1705644149257 0.481481481481481 10.1 10 1 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 SIGNALING EVENTS 0.0285186691116327 0.0618451730652758 1.1705644149257 0.481481481481481 10.1 10 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0285186691116327 0.0618451730652758 1.1705644149257 0.481481481481481 10.1 10 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.70484927212434e-07 4.67449164143153e-06 1.169424624843 0.481012658227848 10.1 10 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000285505982871646 0.00142861342852472 1.169424624843 0.481012658227848 10.1 10 1 RHEUMATOID ARTHRITIS%KEGG%HSA05323 RHEUMATOID ARTHRITIS 0.00034999588490156 0.00168727449448888 1.16822562488589 0.480519480519481 10.1 10 1 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM%KEGG%HSA00520 AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 0.00370407513643446 0.0117540868047866 1.16696267826439 0.48 10.1 10 1 GLUCONEOGENESIS%HUMANCYC%PWY66-399 GLUCONEOGENESIS 0.0357191200466055 0.0754133863594066 1.16696267826439 0.48 10.1 10 1 MAPK SIGNALING PATHWAY%KEGG%HSA04010 MAPK SIGNALING PATHWAY 2.23175020824518e-10 6.68764238538926e-09 1.16696267826439 0.48 10.1 10 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.000429160726934727 0.00198543304724013 1.16696267826439 0.48 10.1 10 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.10343594337934e-09 4.66114334679943e-08 1.16652659355652 0.479820627802691 10.1 10 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.91352609162482e-06 6.9099232793426e-05 1.16617205314361 0.479674796747967 10.1 10 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.34931685826965e-14 1.27076734116324e-12 1.16358243877744 0.478609625668449 10.1 10 1 MUCIN TYPE O-GLYCAN BIOSYNTHESIS%KEGG%HSA00512 MUCIN TYPE O-GLYCAN BIOSYNTHESIS 0.0448495326664238 0.0906964859212879 1.1627345526185 0.478260869565217 10.1 10 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0448495326664238 0.0906964859212879 1.1627345526185 0.478260869565217 10.1 10 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0448495326664238 0.0906964859212879 1.1627345526185 0.478260869565217 10.1 10 1 CARBOHYDRATE DIGESTION AND ABSORPTION%KEGG%HSA04973 CARBOHYDRATE DIGESTION AND ABSORPTION 0.00862455631658105 0.022972681825075 1.15770106970673 0.476190476190476 10.1 10 1 NICOTINATE AND NICOTINAMIDE METABOLISM%KEGG%HSA00760 NICOTINATE AND NICOTINAMIDE METABOLISM 0.0564784099525713 0.109671257028668 1.15770106970673 0.476190476190476 10.1 10 1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY 0.0564784099525713 0.109671257028668 1.15770106970673 0.476190476190476 10.1 10 1 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY 0.0564784099525713 0.109671257028668 1.15770106970673 0.476190476190476 10.1 10 1 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY 0.0564784099525713 0.109671257028668 1.15770106970673 0.476190476190476 10.1 10 1 PROGESTERONE-MEDIATED OOCYTE MATURATION%KEGG%HSA04914 PROGESTERONE-MEDIATED OOCYTE MATURATION 0.000320245464948498 0.00156993155178288 1.15628923913392 0.475609756097561 10.1 10 1 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS%MSIGDB_C2%ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0.0106755467032487 0.0271994363830598 1.15480681703247 0.475 10.1 10 1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY 0.0106755467032487 0.0271994363830598 1.15480681703247 0.475 10.1 10 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.02804364870719e-06 1.11561773730077e-05 1.15324837328478 0.474358974358974 10.1 10 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000588542028745222 0.00256103189736163 1.15160790618196 0.473684210526316 10.1 10 1 GLYCOLYSIS / GLUCONEOGENESIS%KEGG%HSA00010 GLYCOLYSIS / GLUCONEOGENESIS 0.00272696381697085 0.00923107007105538 1.15160790618196 0.473684210526316 10.1 10 1 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY 0.0713684102408421 0.133285055102762 1.15160790618196 0.473684210526316 10.1 10 1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY 0.0713684102408421 0.133285055102762 1.15160790618196 0.473684210526316 10.1 10 1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY 0.0713684102408421 0.133285055102762 1.15160790618196 0.473684210526316 10.1 10 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0713684102408421 0.133285055102762 1.15160790618196 0.473684210526316 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.57628574302385e-05 0.000250150278630077 1.15046543802107 0.473214285714286 10.1 10 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000159263529125918 0.00086237767208428 1.15023203054734 0.473118279569892 10.1 10 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00335535627263424 0.010829956537254 1.14928142556341 0.472727272727273 10.1 10 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00335535627263424 0.010829956537254 1.14928142556341 0.472727272727273 10.1 10 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00335535627263424 0.010829956537254 1.14928142556341 0.472727272727273 10.1 10 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00335535627263424 0.010829956537254 1.14928142556341 0.472727272727273 10.1 10 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.20706783009915e-05 9.75060083254981e-05 1.14858531325235 0.47244094488189 10.1 10 1 BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY 0.0164061188671816 0.0395095300938429 1.14805356079251 0.472222222222222 10.1 10 1 GNRH SIGNALING PATHWAY%KEGG%HSA04912 GNRH SIGNALING PATHWAY 0.000238080744715064 0.00121906587148277 1.14729476795656 0.471910112359551 10.1 10 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.00413051804531638 0.0128749126306138 1.14677936150195 0.471698113207547 10.1 10 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00413051804531638 0.0128749126306138 1.14677936150195 0.471698113207547 10.1 10 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00108377723949203 0.00431710057483458 1.14612405900967 0.471428571428571 10.1 10 1 ECM-RECEPTOR INTERACTION%KEGG%HSA04512 ECM-RECEPTOR INTERACTION 0.000356091690798086 0.00170729779751737 1.14408105712195 0.470588235294118 10.1 10 1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES%MSIGDB_C2%SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0.0203731477420871 0.0478397066748742 1.14408105712195 0.470588235294118 10.1 10 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0203731477420871 0.0478397066748742 1.14408105712195 0.470588235294118 10.1 10 1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7219 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0905587816724755 0.158043353587239 1.14408105712195 0.470588235294118 10.1 10 1 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY 0.0905587816724755 0.158043353587239 1.14408105712195 0.470588235294118 10.1 10 1 GLYCOLYSIS%PANTHER PATHWAY%P00024 GLYCOLYSIS 0.0905587816724755 0.158043353587239 1.14408105712195 0.470588235294118 10.1 10 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0905587816724755 0.158043353587239 1.14408105712195 0.470588235294118 10.1 10 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0905587816724755 0.158043353587239 1.14408105712195 0.470588235294118 10.1 10 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0905587816724755 0.158043353587239 1.14408105712195 0.470588235294118 10.1 10 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.000118365789098726 0.000688330827900852 1.14265095580055 0.47 10.1 10 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.000144534086946875 0.000821414627756273 1.14116248299664 0.469387755102041 10.1 10 1 ANTIGEN PROCESSING AND PRESENTATION%KEGG%HSA04612 ANTIGEN PROCESSING AND PRESENTATION 0.0062692345899978 0.0180086836751898 1.14116248299664 0.469387755102041 10.1 10 1 PNAT%PANTHER PATHWAY%P05912 PNAT 0.0062692345899978 0.0180086836751898 1.14116248299664 0.469387755102041 10.1 10 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.94792591367056e-05 0.000209533170737177 1.13587555773685 0.467213114754098 10.1 10 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.58470727918392e-08 8.71412609183905e-07 1.1345470483126 0.466666666666667 10.1 10 1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY MTOR SIGNALING PATHWAY 0.00301433842644436 0.010087322881388 1.1345470483126 0.466666666666667 10.1 10 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00953765248120864 0.0248022487063142 1.1345470483126 0.466666666666667 10.1 10 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0315451367023928 0.0676847237463058 1.1345470483126 0.466666666666667 10.1 10 1 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-MEDIATED THROMBIN SIGNALING EVENTS 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-MEDIATED SIGNALING EVENTS 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ERBB RECEPTOR SIGNALING NETWORK 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.115494246605314 0.193986196368288 1.1345470483126 0.466666666666667 10.1 10 1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY 4.37594497998529e-05 0.000298947329332155 1.13317350467057 0.466101694915254 10.1 10 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.55308929950284e-07 4.5263268032797e-06 1.13108013601829 0.46524064171123 10.1 10 1 SIG_CHEMOTAXIS%MSIGDB_C2%SIG_CHEMOTAXIS SIG_CHEMOTAXIS 0.0117756667326976 0.0296868385985884 1.13077778901588 0.465116279069767 10.1 10 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.49594668656793e-05 0.000419068202780197 1.13028183384526 0.464912280701754 10.1 10 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.66182900649377e-05 0.000193367578240333 1.12944222469814 0.464566929133858 10.1 10 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.71461984396579e-06 3.52354407501359e-05 1.12931872090102 0.464516129032258 10.1 10 1 GLUTAMATERGIC SYNAPSE%KEGG%HSA04724 GLUTAMATERGIC SYNAPSE 7.91466965963053e-05 0.00048537171842897 1.12875854296407 0.464285714285714 10.1 10 1 HISTIDINE METABOLISM%KEGG%HSA00340 HISTIDINE METABOLISM 0.0393456380130616 0.0821492062077938 1.12875854296407 0.464285714285714 10.1 10 1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS BETA2 INTEGRIN CELL SURFACE INTERACTIONS 0.0393456380130616 0.0821492062077938 1.12875854296407 0.464285714285714 10.1 10 1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 GENERAL TRANSCRIPTION REGULATION 0.0393456380130616 0.0821492062077938 1.12875854296407 0.464285714285714 10.1 10 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0393456380130616 0.0821492062077938 1.12875854296407 0.464285714285714 10.1 10 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.26876237836999e-06 2.2922323340083e-05 1.12664079710485 0.463414634146341 10.1 10 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.01454947049742 0.0355908661425757 1.12664079710485 0.463414634146341 10.1 10 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.47080881790686e-24 4.30946983646711e-22 1.12375567342468 0.462227912932138 10.1 10 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.24398974677476e-09 2.9030097011018e-08 1.12342977450242 0.462093862815884 10.1 10 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.9020392813119e-27 7.16525369259926e-25 1.12207949833114 0.461538461538462 10.1 10 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.19833063582828e-05 9.75060083254981e-05 1.12207949833114 0.461538461538462 10.1 10 1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING P75(NTR)-MEDIATED SIGNALING 0.00269090750276311 0.00912072375936544 1.12207949833114 0.461538461538462 10.1 10 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00687324871375214 0.0193021904772784 1.12207949833114 0.461538461538462 10.1 10 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0491657444900707 0.0991208472632389 1.12207949833114 0.461538461538462 10.1 10 1 L-KYNURENINE DEGRADATION%HUMANCYC%PWY-6309 L-KYNURENINE DEGRADATION 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY RAS SIGNALING IN THE CD4+ TCR PATHWAY 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.148236269440123 0.239521472128435 1.12207949833114 0.461538461538462 10.1 10 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000525053173569577 0.00229994222375909 1.11997822586236 0.460674157303371 10.1 10 1 GLYCEROPHOSPHOLIPID METABOLISM%KEGG%HSA00564 GLYCEROPHOSPHOLIPID METABOLISM 0.00130815611122824 0.00499943139899838 1.11961879767691 0.460526315789474 10.1 10 1 BILE SECRETION%KEGG%HSA04976 BILE SECRETION 0.00329748076106549 0.0107055449734678 1.11911103404984 0.46031746031746 10.1 10 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00329748076106549 0.0107055449734678 1.11911103404984 0.46031746031746 10.1 10 1 OOCYTE MEIOSIS%KEGG%HSA04114 OOCYTE MEIOSIS 0.000258950431822433 0.00130814614696505 1.11833923333671 0.46 10.1 10 1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS 0.00845437042081096 0.0225649542506867 1.11833923333671 0.46 10.1 10 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00845437042081096 0.0225649542506867 1.11833923333671 0.46 10.1 10 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00845437042081096 0.0225649542506867 1.11833923333671 0.46 10.1 10 1 PANCREATIC SECRETION%KEGG%HSA04972 PANCREATIC SECRETION 0.000640633201069365 0.00275587235109285 1.11778034316512 0.459770114942529 10.1 10 1 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-MEDIATED SIGNALING EVENTS 0.0222654819958184 0.0510113605759975 1.1170250861765 0.459459459459459 10.1 10 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0222654819958184 0.0510113605759975 1.1170250861765 0.459459459459459 10.1 10 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.1758872173446e-05 0.000225129424519831 1.11504892503333 0.458646616541353 10.1 10 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00195503813237697 0.00696680480415955 1.11428727959273 0.458333333333333 10.1 10 1 VIBRIO CHOLERAE INFECTION%KEGG%HSA05110 VIBRIO CHOLERAE INFECTION 0.0104037854330266 0.0265583564248705 1.11428727959273 0.458333333333333 10.1 10 1 CYTOSOLIC DNA-SENSING PATHWAY%KEGG%HSA04623 CYTOSOLIC DNA-SENSING PATHWAY 0.0104037854330266 0.0265583564248705 1.11428727959273 0.458333333333333 10.1 10 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0104037854330266 0.0265583564248705 1.11428727959273 0.458333333333333 10.1 10 1 PENTOSE AND GLUCURONATE INTERCONVERSIONS%KEGG%HSA00040 PENTOSE AND GLUCURONATE INTERCONVERSIONS 0.061565939439584 0.119199252791618 1.11428727959273 0.458333333333333 10.1 10 1 ST_GRANULE_CELL_SURVIVAL_PATHWAY%MSIGDB_C2%ST_GRANULE_CELL_SURVIVAL_PATHWAY ST_GRANULE_CELL_SURVIVAL_PATHWAY 0.061565939439584 0.119199252791618 1.11428727959273 0.458333333333333 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.061565939439584 0.119199252791618 1.11428727959273 0.458333333333333 10.1 10 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.061565939439584 0.119199252791618 1.11428727959273 0.458333333333333 10.1 10 1 WNT SIGNALING PATHWAY%KEGG%HSA04310 WNT SIGNALING PATHWAY 1.92610652450253e-05 0.000145534180662269 1.11286053531668 0.457746478873239 10.1 10 1 TIGHT JUNCTION%KEGG%HSA04530 TIGHT JUNCTION 9.4221636981003e-05 0.000569868019997488 1.1125703500402 0.457627118644068 10.1 10 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0049549286923506 0.0149669495552446 1.1125703500402 0.457627118644068 10.1 10 1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 INTERNALIZATION OF ERBB1 0.0275815090507297 0.0601679584509609 1.11139302691846 0.457142857142857 10.1 10 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0275815090507297 0.0601679584509609 1.11139302691846 0.457142857142857 10.1 10 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0275815090507297 0.0601679584509609 1.11139302691846 0.457142857142857 10.1 10 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.5383499568259e-10 5.0081837483332e-09 1.11117995310195 0.457055214723926 10.1 10 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00116392152663285 0.00460850009869493 1.11053547057053 0.45679012345679 10.1 10 1 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY 0.0128086624813166 0.0316895235696732 1.10988298204493 0.456521739130435 10.1 10 1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK NOTCH-MEDIATED HES HEY NETWORK 0.0128086624813166 0.0316895235696732 1.10988298204493 0.456521739130435 10.1 10 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0128086624813166 0.0316895235696732 1.10988298204493 0.456521739130435 10.1 10 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0128086624813166 0.0316895235696732 1.10988298204493 0.456521739130435 10.1 10 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0128086624813166 0.0316895235696732 1.10988298204493 0.456521739130435 10.1 10 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0128086624813166 0.0316895235696732 1.10988298204493 0.456521739130435 10.1 10 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.9890957525038e-08 3.52029899285404e-07 1.10946352513562 0.456349206349206 10.1 10 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.9890957525038e-08 3.52029899285404e-07 1.10946352513562 0.456349206349206 10.1 10 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.9890957525038e-08 3.52029899285404e-07 1.10946352513562 0.456349206349206 10.1 10 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 8.46528355173979e-08 1.28292831758263e-06 1.10602685887004 0.454935622317597 10.1 10 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000847117208845742 0.00350132927856774 1.10507829381097 0.454545454545455 10.1 10 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0074524700108243 0.0204072309642198 1.10507829381097 0.454545454545455 10.1 10 1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY FANCONI ANEMIA PATHWAY 0.015777224781337 0.0380993972054813 1.10507829381097 0.454545454545455 10.1 10 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.015777224781337 0.0380993972054813 1.10507829381097 0.454545454545455 10.1 10 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0342017298586139 0.0723255506312469 1.10507829381097 0.454545454545455 10.1 10 1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY 0.0772794545236145 0.142070220156406 1.10507829381097 0.454545454545455 10.1 10 1 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE 0.0772794545236145 0.142070220156406 1.10507829381097 0.454545454545455 10.1 10 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0772794545236145 0.142070220156406 1.10507829381097 0.454545454545455 10.1 10 1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7176 UTP AND CTP DE NOVO< I> BIOSYNTHESIS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7221 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 RIBOFLAVIN METABOLISM%KEGG%HSA00740 RIBOFLAVIN METABOLISM 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.191830907660326 0.294445927532176 1.10507829381097 0.454545454545455 10.1 10 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00437223976930354 0.0135802076226778 1.10162492414281 0.453125 10.1 10 1 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS BETA3 INTEGRIN CELL SURFACE INTERACTIONS 0.0194439648207218 0.0458620172023643 1.0998160162214 0.452380952380952 10.1 10 1 WNT%NETPATH%WNT WNT 0.000182758863210437 0.000967741209409482 1.09931266793022 0.452173913043478 10.1 10 1 PYRIMIDINE METABOLISM%KEGG%HSA00240 PYRIMIDINE METABOLISM 0.000750162358563455 0.00315498905826448 1.09794875643155 0.451612903225806 10.1 10 1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY NONCANONICAL WNT SIGNALING PATHWAY 0.0424584939332102 0.086320678360305 1.09794875643155 0.451612903225806 10.1 10 1 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS SIGNALING PATHWAY 0.0424584939332102 0.086320678360305 1.09794875643155 0.451612903225806 10.1 10 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00153175189103929 0.00567307547285197 1.09699235507577 0.451219512195122 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0239761884948892 0.0547878761360683 1.09402751087286 0.45 10.1 10 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0972742803770105 0.168536318892363 1.09402751087286 0.45 10.1 10 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0972742803770105 0.168536318892363 1.09402751087286 0.45 10.1 10 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0972742803770105 0.168536318892363 1.09402751087286 0.45 10.1 10 1 MELANOMA%KEGG%HSA05218 MELANOMA 0.00384485629876988 0.0121133644681675 1.09226579185374 0.449275362318841 10.1 10 1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 SIGNALING MEDIATED BY STAT4 0.0527734623039137 0.103698673692564 1.08983583458599 0.448275862068966 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0527734623039137 0.103698673692564 1.08983583458599 0.448275862068966 10.1 10 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00135009698773965 0.00510058131328002 1.08983583458599 0.448275862068966 10.1 10 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00135009698773965 0.00510058131328002 1.08983583458599 0.448275862068966 10.1 10 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.90828874062003e-06 2.88314188308835e-05 1.0889625686929 0.447916666666667 10.1 10 1 WNT%IOB%WNT WNT 0.000288764917350488 0.00144218387699477 1.08762968917185 0.447368421052632 10.1 10 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0295822364158128 0.0639937304581611 1.08762968917185 0.447368421052632 10.1 10 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00164192258168596 0.00597206875573223 1.08687700426585 0.447058823529412 10.1 10 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00164192258168596 0.00597206875573223 1.08687700426585 0.447058823529412 10.1 10 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00164192258168596 0.00597206875573223 1.08687700426585 0.447058823529412 10.1 10 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00164192258168596 0.00597206875573223 1.08687700426585 0.447058823529412 10.1 10 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00164192258168596 0.00597206875573223 1.08687700426585 0.447058823529412 10.1 10 1 TYPE II DIABETES MELLITUS%KEGG%HSA04930 TYPE II DIABETES MELLITUS 0.0169104855814443 0.040686998611559 1.08626845051206 0.446808510638298 10.1 10 1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 SIGNALING 0.0097944967741107 0.0252968540581096 1.08534475285006 0.446428571428571 10.1 10 1 GAP JUNCTION%KEGG%HSA04540 GAP JUNCTION 0.00242759861754823 0.00834625496020167 1.08052099839295 0.444444444444444 10.1 10 1 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-841 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.0365218211975681 0.0768082359770804 1.08052099839295 0.444444444444444 10.1 10 1 PORPHYRIN AND CHLOROPHYLL METABOLISM%KEGG%HSA00860 PORPHYRIN AND CHLOROPHYLL METABOLISM 0.0365218211975681 0.0768082359770804 1.08052099839295 0.444444444444444 10.1 10 1 ST_JNK_MAPK_PATHWAY%MSIGDB_C2%ST_JNK_MAPK_PATHWAY ST_JNK_MAPK_PATHWAY 0.0365218211975681 0.0768082359770804 1.08052099839295 0.444444444444444 10.1 10 1 GLYOXYLATE AND DICARBOXYLATE METABOLISM%KEGG%HSA00630 GLYOXYLATE AND DICARBOXYLATE METABOLISM 0.122842423680487 0.205542811703962 1.08052099839295 0.444444444444444 10.1 10 1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY 0.122842423680487 0.205542811703962 1.08052099839295 0.444444444444444 10.1 10 1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 HEDGEHOG SIGNALING PATHWAY 0.122842423680487 0.205542811703962 1.08052099839295 0.444444444444444 10.1 10 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.122842423680487 0.205542811703962 1.08052099839295 0.444444444444444 10.1 10 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.122842423680487 0.205542811703962 1.08052099839295 0.444444444444444 10.1 10 1 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION%KEGG%HSA05120 EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 0.00698876940879331 0.0195848936567353 1.08052099839295 0.444444444444444 10.1 10 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00698876940879331 0.0195848936567353 1.08052099839295 0.444444444444444 10.1 10 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0656834047928214 0.124609452114151 1.08052099839295 0.444444444444444 10.1 10 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0656834047928214 0.124609452114151 1.08052099839295 0.444444444444444 10.1 10 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0656834047928214 0.124609452114151 1.08052099839295 0.444444444444444 10.1 10 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0656834047928214 0.124609452114151 1.08052099839295 0.444444444444444 10.1 10 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.001042447793643 0.00420970112072986 1.07773615045895 0.443298969072165 10.1 10 1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 INTERLEUKIN SIGNALING PATHWAY 0.00175042783216542 0.00634049202392887 1.0774513364657 0.443181818181818 10.1 10 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00175042783216542 0.00634049202392887 1.0774513364657 0.443181818181818 10.1 10 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00500095494271026 0.0150886935742871 1.07666199482726 0.442857142857143 10.1 10 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.91029580438191e-05 0.000144754311383767 1.07423889956509 0.441860465116279 10.1 10 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000661407910718334 0.00283598806595813 1.07060796171045 0.440366972477064 10.1 10 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.22803461496932e-05 9.87294902339664e-05 1.07024430411476 0.440217391304348 10.1 10 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00110643401139243 0.00439733662878465 1.06971578840902 0.44 10.1 10 1 HOMOLOGOUS RECOMBINATION%KEGG%HSA03440 HOMOLOGOUS RECOMBINATION 0.0818741546769245 0.148488408447765 1.06971578840902 0.44 10.1 10 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0818741546769245 0.148488408447765 1.06971578840902 0.44 10.1 10 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0818741546769245 0.148488408447765 1.06971578840902 0.44 10.1 10 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0818741546769245 0.148488408447765 1.06971578840902 0.44 10.1 10 1 CALCIUM SIGNALING PATHWAY%KEGG%HSA04020 CALCIUM SIGNALING PATHWAY 3.34715869740241e-05 0.000236001537033426 1.06912996377134 0.439759036144578 10.1 10 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.50517793339908e-07 4.48696806328804e-06 1.06780898664715 0.43921568627451 10.1 10 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00312869605568566 0.0104039993680241 1.0673439130467 0.439024390243902 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0313536199711695 0.0674934660114074 1.0673439130467 0.439024390243902 10.1 10 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0313536199711695 0.0674934660114074 1.0673439130467 0.439024390243902 10.1 10 1 VIRAL MYOCARDITIS%KEGG%HSA05416 VIRAL MYOCARDITIS 0.0126995905304307 0.0316529491765083 1.06630361683515 0.43859649122807 10.1 10 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00529720582794633 0.0159642648780508 1.06571934088072 0.438356164383562 10.1 10 1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-CADHERIN SIGNALING EVENTS 0.0557786879772297 0.108632496451961 1.06363785779306 0.4375 10.1 10 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0557786879772297 0.108632496451961 1.06363785779306 0.4375 10.1 10 1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.155731528133873 0.246793293082345 1.06363785779306 0.4375 10.1 10 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.80357371032343e-12 2.12624801384598e-10 1.06087516205853 0.436363636363636 10.1 10 1 FATTY ACID METABOLISM%KEGG%HSA00071 FATTY ACID METABOLISM 0.0385391784322561 0.0807210591944871 1.05974174842386 0.435897435897436 10.1 10 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0385391784322561 0.0807210591944871 1.05974174842386 0.435897435897436 10.1 10 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0109823826665244 0.0277432535818126 1.05873630084471 0.435483870967742 10.1 10 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00330057188601793 0.0107055449734678 1.0582749778378 0.435294117647059 10.1 10 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00330057188601793 0.0107055449734678 1.0582749778378 0.435294117647059 10.1 10 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000320892342211214 0.00156993155178288 1.0578383056786 0.435114503816794 10.1 10 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000320892342211214 0.00156993155178288 1.0578383056786 0.435114503816794 10.1 10 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.0023719024117537 0.00827342150766468 1.05703141147137 0.434782608695652 10.1 10 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00781561003627632 0.0211984860325068 1.05703141147137 0.434782608695652 10.1 10 1 GLYCEROLIPID METABOLISM%KEGG%HSA00561 GLYCEROLIPID METABOLISM 0.0268921288830726 0.0592435621258666 1.05703141147137 0.434782608695652 10.1 10 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0268921288830726 0.0592435621258666 1.05703141147137 0.434782608695652 10.1 10 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0268921288830726 0.0592435621258666 1.05703141147137 0.434782608695652 10.1 10 1 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 0.102225548259915 0.176534885894823 1.05703141147137 0.434782608695652 10.1 10 1 ST_MYOCYTE_AD_PATHWAY%MSIGDB_C2%ST_MYOCYTE_AD_PATHWAY ST_MYOCYTE_AD_PATHWAY 0.102225548259915 0.176534885894823 1.05703141147137 0.434782608695652 10.1 10 1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY 0.102225548259915 0.176534885894823 1.05703141147137 0.434782608695652 10.1 10 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.102225548259915 0.176534885894823 1.05703141147137 0.434782608695652 10.1 10 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.102225548259915 0.176534885894823 1.05703141147137 0.434782608695652 10.1 10 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.84925317432247e-13 1.52390019396511e-11 1.05592069545231 0.434325744308231 10.1 10 1 CITRATE CYCLE (TCA CYCLE)%KEGG%HSA00020 CITRATE CYCLE (TCA CYCLE) 0.0690068877639002 0.129240882836225 1.05350797343313 0.433333333333333 10.1 10 1 ST_WNT_BETA_CATENIN_PATHWAY%MSIGDB_C2%ST_WNT_BETA_CATENIN_PATHWAY ST_WNT_BETA_CATENIN_PATHWAY 0.0690068877639002 0.129240882836225 1.05350797343313 0.433333333333333 10.1 10 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0690068877639002 0.129240882836225 1.05350797343313 0.433333333333333 10.1 10 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000465576651425638 0.00210394669617911 1.05286987048132 0.433070866141732 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00948973345813049 0.0248022487063142 1.05229843500209 0.432835820895522 10.1 10 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00676397025045795 0.0190503411209888 1.05131772816612 0.432432432432432 10.1 10 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00676397025045795 0.0190503411209888 1.05131772816612 0.432432432432432 10.1 10 1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB FORWARD SIGNALING 0.0473837939227105 0.0956014266061114 1.05131772816612 0.432432432432432 10.1 10 1 ID%NETPATH%ID ID 0.0473837939227105 0.0956014266061114 1.05131772816612 0.432432432432432 10.1 10 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.27091239741631e-14 1.24125777480993e-12 1.05111335069174 0.432348367029549 10.1 10 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00819560105287097 0.0220979549861153 1.04675471719317 0.430555555555556 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00819560105287097 0.0220979549861153 1.04675471719317 0.430555555555556 10.1 10 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00585066901203811 0.0168614362674803 1.04632729591216 0.430379746835443 10.1 10 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00216132862708668 0.00759923145283675 1.04540406594518 0.43 10.1 10 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00155694991533361 0.005758312660217 1.04517685358571 0.429906542056075 10.1 10 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.35350671329168e-32 2.06873240098338e-29 1.04372468937731 0.429309231762427 10.1 10 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0281201826018084 0.0611318396710378 1.04193096273606 0.428571428571429 10.1 10 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0854367298776409 0.151307358419973 1.04193096273606 0.428571428571429 10.1 10 1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%HUMANCYC%PWY-7210 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7184 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 GLYCOSAMINOGLYCAN BIOSYNTHESIS - KERATAN SULFATE%KEGG%HSA00533 GLYCOSAMINOGLYCAN BIOSYNTHESIS - KERATAN SULFATE 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.19834452366342 0.302332086069617 1.04193096273606 0.428571428571429 10.1 10 1 VITAMIN DIGESTION AND ABSORPTION%KEGG%HSA04977 VITAMIN DIGESTION AND ABSORPTION 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 DORSO-VENTRAL AXIS FORMATION%KEGG%HSA04320 DORSO-VENTRAL AXIS FORMATION 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.12787118319534 0.212876458387697 1.04193096273606 0.428571428571429 10.1 10 1 METABOLIC PATHWAYS%KEGG%HSA01100 METABOLIC PATHWAYS 1.17971782070344e-21 2.39301222553459e-19 1.04059771774216 0.428023032629559 10.1 10 1 HEMATOPOIETIC CELL LINEAGE%KEGG%HSA04640 HEMATOPOIETIC CELL LINEAGE 0.00855328075957437 0.022805865887763 1.03730015845723 0.426666666666667 10.1 10 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.01201833870479 0.030269684015789 1.03682345801677 0.426470588235294 10.1 10 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.11739611807478e-06 3.83596439612371e-05 1.0349568599065 0.42570281124498 10.1 10 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00377945955650717 0.0119215727876907 1.03454138144006 0.425531914893617 10.1 10 1 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS ARF6 TRAFFICKING EVENTS 0.0342859387361307 0.0724455292044684 1.03454138144006 0.425531914893617 10.1 10 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0493031275163969 0.0993218848439561 1.03324820471326 0.425 10.1 10 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0205567401378774 0.0482278680992728 1.0301577315187 0.423728813559322 10.1 10 1 CYTOKINE-CYTOKINE RECEPTOR INTERACTION%KEGG%HSA04060 CYTOKINE-CYTOKINE RECEPTOR INTERACTION 1.80282106027991e-05 0.000138198812091806 1.02941527549599 0.423423423423423 10.1 10 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0088888993144235 0.0233609131972072 1.02857287347021 0.423076923076923 10.1 10 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0292105299836775 0.0632415168858437 1.02857287347021 0.423076923076923 10.1 10 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0292105299836775 0.0632415168858437 1.02857287347021 0.423076923076923 10.1 10 1 ID%IOB%ID ID 0.105860322147284 0.18115098604957 1.02857287347021 0.423076923076923 10.1 10 1 GLYCOSAMINOGLYCAN BIOSYNTHESIS - HEPARAN SULFATE%KEGG%HSA00534 GLYCOSAMINOGLYCAN BIOSYNTHESIS - HEPARAN SULFATE 0.105860322147284 0.18115098604957 1.02857287347021 0.423076923076923 10.1 10 1 BETA-ALANINE METABOLISM%KEGG%HSA00410 BETA-ALANINE METABOLISM 0.105860322147284 0.18115098604957 1.02857287347021 0.423076923076923 10.1 10 1 COLLECTING DUCT ACID SECRETION%KEGG%HSA04966 COLLECTING DUCT ACID SECRETION 0.105860322147284 0.18115098604957 1.02857287347021 0.423076923076923 10.1 10 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.105860322147284 0.18115098604957 1.02857287347021 0.423076923076923 10.1 10 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.0124813465605453 0.0311384208894587 1.02725587875386 0.422535211267606 10.1 10 1 N-GLYCAN BIOSYNTHESIS%KEGG%HSA00510 N-GLYCAN BIOSYNTHESIS 0.0417913248688927 0.0854292431622248 1.0264949484733 0.422222222222222 10.1 10 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0417913248688927 0.0854292431622248 1.0264949484733 0.422222222222222 10.1 10 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0107152579676296 0.027274261834594 1.02365147216174 0.421052631578947 10.1 10 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0249123483746121 0.0561966318766913 1.02365147216174 0.421052631578947 10.1 10 1 GLYCOSAMINOGLYCAN DEGRADATION%KEGG%HSA00531 GLYCOSAMINOGLYCAN DEGRADATION 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY%MSIGDB_C2%ST_WNT_CA2_CYCLIC_GMP_PATHWAY ST_WNT_CA2_CYCLIC_GMP_PATHWAY 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.16027806981841 0.252631960616346 1.02365147216174 0.421052631578947 10.1 10 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00920286288666353 0.0241232101711051 1.02049205403779 0.419753086419753 10.1 10 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0881807277527319 0.155311568963183 1.01952384525787 0.419354838709677 10.1 10 1 WNT_SIGNALING%MSIGDB_C2%WNT_SIGNALING WNT_SIGNALING 0.00790720324694723 0.0213640317235654 1.01770001011429 0.418604651162791 10.1 10 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00790720324694723 0.0213640317235654 1.01770001011429 0.418604651162791 10.1 10 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.00302339856143976 0.0101048187661808 1.0166720303061 0.418181818181818 10.1 10 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0301744265467776 0.0652212809867643 1.0166720303061 0.418181818181818 10.1 10 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0430821432879762 0.0873904706541486 1.01298843599339 0.416666666666667 10.1 10 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0430821432879762 0.0873904706541486 1.01298843599339 0.416666666666667 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0738081392394673 0.137743852211235 1.01298843599339 0.416666666666667 10.1 10 1 GLYCOLYSIS%HUMANCYC%PWY66-400 GLYCOLYSIS 0.131268125988722 0.218118492899975 1.01298843599339 0.416666666666667 10.1 10 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.131268125988722 0.218118492899975 1.01298843599339 0.416666666666667 10.1 10 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.131268125988722 0.218118492899975 1.01298843599339 0.416666666666667 10.1 10 1 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.254052345847341 0.35863813490334 1.01298843599339 0.416666666666667 10.1 10 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0365254182462112 0.0768082359770804 1.00916583812172 0.415094339622642 10.1 10 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0365254182462112 0.0768082359770804 1.00916583812172 0.415094339622642 10.1 10 1 VASOPRESSIN-REGULATED WATER REABSORPTION%KEGG%HSA04962 VASOPRESSIN-REGULATED WATER REABSORPTION 0.0620173620275996 0.119721657149912 1.00804702898855 0.414634146341463 10.1 10 1 TASTE TRANSDUCTION%KEGG%HSA04742 TASTE TRANSDUCTION 0.0620173620275996 0.119721657149912 1.00804702898855 0.414634146341463 10.1 10 1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS 0.0620173620275996 0.119721657149912 1.00804702898855 0.414634146341463 10.1 10 1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY 0.0620173620275996 0.119721657149912 1.00804702898855 0.414634146341463 10.1 10 1 PPAR SIGNALING PATHWAY%KEGG%HSA03320 PPAR SIGNALING PATHWAY 0.0187000182908609 0.0441467754995525 1.00719993064486 0.414285714285714 10.1 10 1 CELL ADHESION MOLECULES (CAMS)%KEGG%HSA04514 CELL ADHESION MOLECULES (CAMS) 0.00320729955957445 0.010614942618177 1.00600230884861 0.413793103448276 10.1 10 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.031022513695184 0.0668899171007361 1.00600230884861 0.413793103448276 10.1 10 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.031022513695184 0.0668899171007361 1.00600230884861 0.413793103448276 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.031022513695184 0.0668899171007361 1.00600230884861 0.413793103448276 10.1 10 1 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY 0.108493154047331 0.185535957991447 1.00600230884861 0.413793103448276 10.1 10 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.00444672804290705 0.0137953198225246 1.00369496410354 0.412844036697248 10.1 10 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.00329285692174919 0.0107055449734678 1.00107092498171 0.411764705882353 10.1 10 1 ARGININE AND PROLINE METABOLISM%KEGG%HSA00330 ARGININE AND PROLINE METABOLISM 0.0441820458970801 0.0895526941049963 1.0010709249817 0.411764705882353 10.1 10 1 OTHER GLYCAN DEGRADATION%KEGG%HSA00511 OTHER GLYCAN DEGRADATION 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.201352450656851 0.303977375236961 1.0010709249817 0.411764705882353 10.1 10 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00283517958010518 0.00958508788812484 0.999917617464445 0.411290322580645 10.1 10 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.162896226121919 0.255688897787798 0.994570464429876 0.409090909090909 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.162896226121919 0.255688897787798 0.994570464429876 0.409090909090909 10.1 10 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.162896226121919 0.255688897787798 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00543210999161518 0.0160588274079476 0.994570464429876 0.409090909090909 10.1 10 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0534007368646435 0.104853122198112 0.992315202605772 0.408163265306122 10.1 10 1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY 0.133481952828477 0.220961650727365 0.990477581860206 0.407407407407407 10.1 10 1 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 NICOTINE PHARMACODYNAMICS PATHWAY 0.133481952828477 0.220961650727365 0.990477581860206 0.407407407407407 10.1 10 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.133481952828477 0.220961650727365 0.990477581860206 0.407407407407407 10.1 10 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.133481952828477 0.220961650727365 0.990477581860206 0.407407407407407 10.1 10 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.110350544441233 0.188467866380526 0.987663725093557 0.40625 10.1 10 1 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR SIGNALING PATHWAY 0.0918247383190742 0.160040869099404 0.985610370155733 0.405405405405405 10.1 10 1 PURINE METABOLISM%KEGG%HSA00230 PURINE METABOLISM 0.00166681077493741 0.00605424244285118 0.985180910299456 0.405228758169935 10.1 10 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00486344728515659 0.0147074661593554 0.984524298122503 0.40495867768595 10.1 10 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0170571466618862 0.0407424780320596 0.984045909250724 0.404761904761905 10.1 10 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0170571466618862 0.0407424780320596 0.984045909250724 0.404761904761905 10.1 10 1 FAT DIGESTION AND ABSORPTION%KEGG%HSA04975 FAT DIGESTION AND ABSORPTION 0.0767947824992438 0.142070220156406 0.984045909250724 0.404761904761905 10.1 10 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0767947824992438 0.142070220156406 0.984045909250724 0.404761904761905 10.1 10 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00203975797924321 0.00723935638124405 0.975565933262426 0.401273885350318 10.1 10 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.164197440196587 0.257388793658383 0.972468898553656 0.4 10.1 10 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.202280596112676 0.303977375236961 0.972468898553656 0.4 10.1 10 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00240540684045447 0.00830206836603441 0.972468898553656 0.4 10.1 10 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0150426596592063 0.0366274178405604 0.972468898553656 0.4 10.1 10 1 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY PHOSPHOLIPASES 0.11159926208689 0.190230933499114 0.972468898553656 0.4 10.1 10 1 OTHER TYPES OF O-GLYCAN BIOSYNTHESIS%KEGG%HSA00514 OTHER TYPES OF O-GLYCAN BIOSYNTHESIS 0.11159926208689 0.190230933499114 0.972468898553656 0.4 10.1 10 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.11159926208689 0.190230933499114 0.972468898553656 0.4 10.1 10 1 BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY 0.134817331569617 0.221164828042793 0.972468898553656 0.4 10.1 10 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.134817331569617 0.221164828042793 0.972468898553656 0.4 10.1 10 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.253578041702157 0.35863813490334 0.972468898553656 0.4 10.1 10 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.253578041702157 0.35863813490334 0.972468898553656 0.4 10.1 10 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.253578041702157 0.35863813490334 0.972468898553656 0.4 10.1 10 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.253578041702157 0.35863813490334 0.972468898553656 0.4 10.1 10 1 MELANOGENESIS%KEGG%HSA04916 MELANOGENESIS 0.0178369407048149 0.0425665272747482 0.967240571142078 0.397849462365591 10.1 10 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0470590991229297 0.0950918347794373 0.964750891422278 0.396825396825397 10.1 10 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0785049924978654 0.144062397506521 0.962339014193722 0.395833333333333 10.1 10 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0937121923053751 0.163114885220643 0.961161120663497 0.395348837209302 10.1 10 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0937121923053751 0.163114885220643 0.961161120663497 0.395348837209302 10.1 10 1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS SYNDECAN-1-MEDIATED SIGNALING EVENTS 0.112364536439913 0.191411681261015 0.959673255151634 0.394736842105263 10.1 10 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.135488023833393 0.221164828042793 0.957734521302843 0.393939393939394 10.1 10 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.135488023833393 0.221164828042793 0.957734521302843 0.393939393939394 10.1 10 1 BUTANOATE METABOLISM%KEGG%HSA00650 BUTANOATE METABOLISM 0.164570038267253 0.25739691038597 0.955103382508055 0.392857142857143 10.1 10 1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY 0.164570038267253 0.25739691038597 0.955103382508055 0.392857142857143 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.164570038267253 0.25739691038597 0.955103382508055 0.392857142857143 10.1 10 1 VASCULAR SMOOTH MUSCLE CONTRACTION%KEGG%HSA04270 VASCULAR SMOOTH MUSCLE CONTRACTION 0.018368354323549 0.0434026436838697 0.953400880934957 0.392156862745098 10.1 10 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00407753230606056 0.0127398728567319 0.951328270324229 0.391304347826087 10.1 10 1 STARCH AND SUCROSE METABOLISM%KEGG%HSA00500 STARCH AND SUCROSE METABOLISM 0.0941814881037501 0.163607762931218 0.951328270324229 0.391304347826087 10.1 10 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0941814881037501 0.163607762931218 0.951328270324229 0.391304347826087 10.1 10 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0941814881037501 0.163607762931218 0.951328270324229 0.391304347826087 10.1 10 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.201898804747494 0.303977375236961 0.951328270324229 0.391304347826087 10.1 10 1 STAPHYLOCOCCUS AUREUS INFECTION%KEGG%HSA05150 STAPHYLOCOCCUS AUREUS INFECTION 0.112742044211848 0.191930775072075 0.948750144930396 0.390243902439024 10.1 10 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00266273513620734 0.00904849555950871 0.946185955349504 0.389189189189189 10.1 10 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00480185510048689 0.0145378781859747 0.945455873593833 0.388888888888889 10.1 10 1 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%HUMANCYC%PWY66-409 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE 0.135648158444341 0.221164828042793 0.945455873593833 0.388888888888889 10.1 10 1 BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY 0.251313376914538 0.357450579786211 0.945455873593833 0.388888888888889 10.1 10 1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY 0.251313376914538 0.357450579786211 0.945455873593833 0.388888888888889 10.1 10 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.251313376914538 0.357450579786211 0.945455873593833 0.388888888888889 10.1 10 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.251313376914538 0.357450579786211 0.945455873593833 0.388888888888889 10.1 10 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.251313376914538 0.357450579786211 0.945455873593833 0.388888888888889 10.1 10 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.164272028717125 0.257388793658383 0.941098934084184 0.387096774193548 10.1 10 1 RIBOSOME BIOGENESIS IN EUKARYOTES%KEGG%HSA03008 RIBOSOME BIOGENESIS IN EUKARYOTES 0.0670978665730618 0.127109967064055 0.935066248609285 0.384615384615385 10.1 10 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.135411447478403 0.221164828042793 0.935066248609285 0.384615384615385 10.1 10 1 GRAFT-VERSUS-HOST DISEASE%KEGG%HSA05332 GRAFT-VERSUS-HOST DISEASE 0.200658138977402 0.303977375236961 0.935066248609285 0.384615384615385 10.1 10 1 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY 0.200658138977402 0.303977375236961 0.935066248609285 0.384615384615385 10.1 10 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.200658138977402 0.303977375236961 0.935066248609285 0.384615384615385 10.1 10 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.200658138977402 0.303977375236961 0.935066248609285 0.384615384615385 10.1 10 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.200658138977402 0.303977375236961 0.935066248609285 0.384615384615385 10.1 10 1 STEARATE BIOSYNTHESIS%HUMANCYC%PWY-5972 STEARATE BIOSYNTHESIS 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 NON-HOMOLOGOUS END-JOINING%KEGG%HSA03450 NON-HOMOLOGOUS END-JOINING 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.320187393601852 0.436799874251466 0.935066248609285 0.384615384615385 10.1 10 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00086444661118402 0.00354517218303617 0.934332863316258 0.384313725490196 10.1 10 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00658580288082895 0.0188769154312456 0.933925923915859 0.384146341463415 10.1 10 1 NEUROACTIVE LIGAND-RECEPTOR INTERACTION%KEGG%HSA04080 NEUROACTIVE LIGAND-RECEPTOR INTERACTION 0.000866956758678817 0.00354994560968329 0.932891675938101 0.383720930232558 10.1 10 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0076460654913053 0.0208939634202819 0.932713880688255 0.383647798742138 10.1 10 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0076460654913053 0.0208939634202819 0.932713880688255 0.383647798742138 10.1 10 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.16348110783031 0.25645430181352 0.929565858911583 0.382352941176471 10.1 10 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.13486343603499 0.221164828042793 0.926160855765387 0.380952380952381 10.1 10 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.248071004061806 0.357450579786211 0.926160855765387 0.380952380952381 10.1 10 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.248071004061806 0.357450579786211 0.926160855765387 0.380952380952381 10.1 10 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.248071004061806 0.357450579786211 0.926160855765387 0.380952380952381 10.1 10 1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 CYTOSKELETAL REGULATION BY RHO GTPASE 0.0792972394562145 0.145415035080694 0.926160855765387 0.380952380952381 10.1 10 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.198839245290538 0.302387018357064 0.922168783111226 0.379310344827586 10.1 10 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.198839245290538 0.302387018357064 0.922168783111226 0.379310344827586 10.1 10 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.198839245290538 0.302387018357064 0.922168783111226 0.379310344827586 10.1 10 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.198839245290538 0.302387018357064 0.922168783111226 0.379310344827586 10.1 10 1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 WNT SIGNALING PATHWAY 0.00206875753838462 0.00733241079129064 0.921819476753987 0.379166666666667 10.1 10 1 PEROXISOME%KEGG%HSA04146 PEROXISOME 0.0667847672638303 0.126607786682042 0.919903012145351 0.378378378378378 10.1 10 1 INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION%KEGG%HSA04672 INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 0.162323283737982 0.255245378185485 0.919903012145351 0.378378378378378 10.1 10 1 FRUCTOSE AND MANNOSE METABOLISM%KEGG%HSA00051 FRUCTOSE AND MANNOSE METABOLISM 0.162323283737982 0.255245378185485 0.919903012145351 0.378378378378378 10.1 10 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.133080611482529 0.220851839194103 0.911689592394053 0.375 10.1 10 1 SPHINGOLIPID METABOLISM%KEGG%HSA00600 SPHINGOLIPID METABOLISM 0.160890088193671 0.253293828398036 0.911689592394053 0.375 10.1 10 1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP RECEPTOR SIGNALING 0.160890088193671 0.253293828398036 0.911689592394053 0.375 10.1 10 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.244277212002757 0.352963840028093 0.911689592394053 0.375 10.1 10 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.244277212002757 0.352963840028093 0.911689592394053 0.375 10.1 10 1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY 0.312285949843128 0.428236115307503 0.911689592394053 0.375 10.1 10 1 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY 0.312285949843128 0.428236115307503 0.911689592394053 0.375 10.1 10 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.312285949843128 0.428236115307503 0.911689592394053 0.375 10.1 10 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0406579986869512 0.0843549508556179 0.911689592394053 0.375 10.1 10 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.00560073549440847 0.016471158289897 0.907488257866891 0.373271889400922 10.1 10 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.13193648889597 0.219091008324101 0.905730836888209 0.372549019607843 10.1 10 1 NUCLEOTIDE EXCISION REPAIR%KEGG%HSA03420 NUCLEOTIDE EXCISION REPAIR 0.159249358245131 0.252216551166613 0.904622231212703 0.372093023255814 10.1 10 1 PROTEIN DIGESTION AND ABSORPTION%KEGG%HSA04974 PROTEIN DIGESTION AND ABSORPTION 0.0916946937248429 0.159919912270113 0.903006834371252 0.371428571428571 10.1 10 1 DNA REPLICATION%KEGG%HSA03030 DNA REPLICATION 0.19413856213324 0.297814652905964 0.903006834371252 0.371428571428571 10.1 10 1 CARDIAC MUSCLE CONTRACTION%KEGG%HSA04260 CARDIAC MUSCLE CONTRACTION 0.109176005598344 0.186582713391338 0.901886478497342 0.370967741935484 10.1 10 1 GALACTOSE METABOLISM%KEGG%HSA00052 GALACTOSE METABOLISM 0.240173542594417 0.347415047625605 0.90043416532746 0.37037037037037 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.240173542594417 0.347415047625605 0.90043416532746 0.37037037037037 10.1 10 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.240173542594417 0.347415047625605 0.90043416532746 0.37037037037037 10.1 10 1 ASCORBATE AND ALDARATE METABOLISM%KEGG%HSA00053 ASCORBATE AND ALDARATE METABOLISM 0.304417306053946 0.418534116821823 0.895695038141526 0.368421052631579 10.1 10 1 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY 0.304417306053946 0.418534116821823 0.895695038141526 0.368421052631579 10.1 10 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.304417306053946 0.418534116821823 0.895695038141526 0.368421052631579 10.1 10 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.033082193804184 0.0703530202109944 0.893813325876522 0.367647058823529 10.1 10 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.155537793014956 0.246793293082345 0.893083682345195 0.36734693877551 10.1 10 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.235904563760546 0.347415047625605 0.891429823674185 0.366666666666667 10.1 10 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0325628303435369 0.0698115313950463 0.890288428253347 0.366197183098592 10.1 10 1 DRUG METABOLISM - OTHER ENZYMES%KEGG%HSA00983 DRUG METABOLISM - OTHER ENZYMES 0.188667805875492 0.292141517377377 0.889453260872247 0.365853658536585 10.1 10 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0376915145493808 0.0790712202599182 0.88728914101611 0.364963503649635 10.1 10 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0376915145493808 0.0790712202599182 0.88728914101611 0.364963503649635 10.1 10 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0373519771147736 0.078483795738373 0.885641318325651 0.364285714285714 10.1 10 1 TYPE I DIABETES MELLITUS%KEGG%HSA04940 TYPE I DIABETES MELLITUS 0.231560288110811 0.341703682007952 0.884062635048779 0.363636363636364 10.1 10 1 PRION DISEASES%KEGG%HSA05020 PRION DISEASES 0.231560288110811 0.341703682007952 0.884062635048779 0.363636363636364 10.1 10 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.231560288110811 0.341703682007952 0.884062635048779 0.363636363636364 10.1 10 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.231560288110811 0.341703682007952 0.884062635048779 0.363636363636364 10.1 10 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.231560288110811 0.341703682007952 0.884062635048779 0.363636363636364 10.1 10 1 NITROGEN METABOLISM%KEGG%HSA00910 NITROGEN METABOLISM 0.296742305741741 0.40862112806317 0.884062635048779 0.363636363636364 10.1 10 1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL SIGNALING PATHWAY 0.296742305741741 0.40862112806317 0.884062635048779 0.363636363636364 10.1 10 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.123218926450552 0.206042047590429 0.880859509559471 0.36231884057971 10.1 10 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.182860128388488 0.283315016780519 0.879360174224051 0.361702127659574 10.1 10 1 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY 0.227198355522618 0.336207667515793 0.877923311194273 0.361111111111111 10.1 10 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.147222471467269 0.239349973649314 0.876816220007395 0.360655737704918 10.1 10 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0213219674591448 0.0494512121282013 0.876209286767888 0.360406091370558 10.1 10 1 OXIDATIVE PHOSPHORYLATION%KEGG%HSA00190 OXIDATIVE PHOSPHORYLATION 0.0815297387116248 0.148271669643141 0.873333719574886 0.359223300970874 10.1 10 1 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 ALZHEIMER DISEASE-PRESENILIN PATHWAY 0.0960210542225863 0.166693561543753 0.870103751337482 0.357894736842105 10.1 10 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.282175489442841 0.396851608352412 0.86827580228005 0.357142857142857 10.1 10 1 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7228 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.387877876900982 0.504107423059581 0.86827580228005 0.357142857142857 10.1 10 1 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY 0.387877876900982 0.504107423059581 0.86827580228005 0.357142857142857 10.1 10 1 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY 0.387877876900982 0.504107423059581 0.86827580228005 0.357142857142857 10.1 10 1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY 0.387877876900982 0.504107423059581 0.86827580228005 0.357142857142857 10.1 10 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.387877876900982 0.504107423059581 0.86827580228005 0.357142857142857 10.1 10 1 ALANINE, ASPARTATE AND GLUTAMATE METABOLISM%KEGG%HSA00250 ALANINE, ASPARTATE AND GLUTAMATE METABOLISM 0.275302458034426 0.387391986038838 0.862674022910502 0.354838709677419 10.1 10 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.134283935033344 0.221164828042793 0.861681302515898 0.354430379746835 10.1 10 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.0139229789979484 0.0340899680757567 0.85959304425725 0.353571428571429 10.1 10 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.268694386445631 0.378295300083891 0.858060792841461 0.352941176470588 10.1 10 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.268694386445631 0.378295300083891 0.858060792841461 0.352941176470588 10.1 10 1 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY 0.37279513121746 0.48642293964396 0.858060792841461 0.352941176470588 10.1 10 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.37279513121746 0.48642293964396 0.858060792841461 0.352941176470588 10.1 10 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.37279513121746 0.48642293964396 0.858060792841461 0.352941176470588 10.1 10 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.37279513121746 0.48642293964396 0.858060792841461 0.352941176470588 10.1 10 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.37279513121746 0.48642293964396 0.858060792841461 0.352941176470588 10.1 10 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.159619637433723 0.252631960616346 0.856046565628219 0.352112676056338 10.1 10 1 TYROSINE METABOLISM%KEGG%HSA00350 TYROSINE METABOLISM 0.262339019405962 0.369742380637905 0.854195654134968 0.351351351351351 10.1 10 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 8.72551160698496e-10 2.15039010351583e-08 0.853875130437357 0.351219512195122 10.1 10 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.00651720569716061 0.0187006217882617 0.85216346780475 0.350515463917526 10.1 10 1 TRYPTOPHAN METABOLISM%KEGG%HSA00380 TRYPTOPHAN METABOLISM 0.256222832641237 0.361315299291413 0.850910286234449 0.35 10.1 10 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.256222832641237 0.361315299291413 0.850910286234449 0.35 10.1 10 1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7211 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 BIOSYNTHESIS OF UNSATURATED FATTY ACIDS%KEGG%HSA01040 BIOSYNTHESIS OF UNSATURATED FATTY ACIDS 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.359413996022322 0.470359656332934 0.850910286234449 0.35 10.1 10 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.316514502142495 0.433809117541455 0.835715459694548 0.34375 10.1 10 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.117988641562382 0.198049680331001 0.827633105152048 0.340425531914894 10.1 10 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.309742171277142 0.42541151336345 0.810390748794714 0.333333333333333 10.1 10 1 RNA POLYMERASE%KEGG%HSA03020 RNA POLYMERASE 0.384305957285757 0.500699016483468 0.810390748794714 0.333333333333333 10.1 10 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.384305957285757 0.500699016483468 0.810390748794714 0.333333333333333 10.1 10 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.433536008368922 0.556589315515506 0.810390748794714 0.333333333333333 10.1 10 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.433536008368922 0.556589315515506 0.810390748794714 0.333333333333333 10.1 10 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.371102723983177 0.485415616638709 0.810390748794714 0.333333333333333 10.1 10 1 GLUTATHIONE-MEDIATED DETOXIFICATION%HUMANCYC%PWY-4061 GLUTATHIONE-MEDIATED DETOXIFICATION 0.455027794500394 0.574944079586746 0.810390748794714 0.333333333333333 10.1 10 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.455027794500394 0.574944079586746 0.810390748794714 0.333333333333333 10.1 10 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.455027794500394 0.574944079586746 0.810390748794714 0.333333333333333 10.1 10 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.455027794500394 0.574944079586746 0.810390748794714 0.333333333333333 10.1 10 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.150308280428727 0.242082623503112 0.80541902640947 0.331288343558282 10.1 10 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.30851328353434 0.423944517290284 0.797105654552177 0.327868852459016 10.1 10 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.237736159841136 0.347415047625605 0.795243258163037 0.327102803738318 10.1 10 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.343956139127108 0.452149720278258 0.793852162084617 0.326530612244898 10.1 10 1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 BLOOD COAGULATION 0.376428098160961 0.490920323862736 0.790130980074846 0.325 10.1 10 1 BASE EXCISION REPAIR%KEGG%HSA03410 BASE EXCISION REPAIR 0.416721898244487 0.537620178899566 0.78424911173682 0.32258064516129 10.1 10 1 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY 0.347967104856672 0.457194447188362 0.782919875954215 0.322033898305085 10.1 10 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.432683547316611 0.556036312998979 0.781448222052045 0.321428571428571 10.1 10 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.316910966261933 0.434126866510502 0.780376276617132 0.320987654320988 10.1 10 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.390458820156169 0.507211777710255 0.775906036080045 0.319148936170213 10.1 10 1 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY 0.493129255591219 0.609615547866826 0.767738604121308 0.315789473684211 10.1 10 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.445528310755204 0.571429063940405 0.764082706006444 0.314285714285714 10.1 10 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.519910451162788 0.632673677764777 0.759741326995044 0.3125 10.1 10 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.519910451162788 0.632673677764777 0.759741326995044 0.3125 10.1 10 1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY 0.480674641850051 0.606288940097937 0.754501731636458 0.310344827586207 10.1 10 1 ARACHIDONIC ACID METABOLISM%KEGG%HSA00590 ARACHIDONIC ACID METABOLISM 0.436508763351842 0.560133143045648 0.751453239791462 0.309090909090909 10.1 10 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.501116581453901 0.613199269277929 0.748052998887428 0.307692307692308 10.1 10 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.353251694752968 0.463906732601383 0.745927848322407 0.306818181818182 10.1 10 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.48853297462426 0.609615547866826 0.742858186395154 0.305555555555556 10.1 10 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.524119039876352 0.636913321729927 0.739921988029956 0.304347826086957 10.1 10 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.524119039876352 0.636913321729927 0.739921988029956 0.304347826086957 10.1 10 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.524119039876352 0.636913321729927 0.739921988029956 0.304347826086957 10.1 10 1 ETHER LIPID METABOLISM%KEGG%HSA00565 ETHER LIPID METABOLISM 0.507174673565851 0.620036909686207 0.736718862540649 0.303030303030303 10.1 10 1 GLYCINE, SERINE AND THREONINE METABOLISM%KEGG%HSA00260 GLYCINE, SERINE AND THREONINE METABOLISM 0.507174673565851 0.620036909686207 0.736718862540649 0.303030303030303 10.1 10 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.550435795406461 0.667049261253142 0.729351673915242 0.3 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.550435795406461 0.667049261253142 0.729351673915242 0.3 10.1 10 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.527634035221568 0.640594360441656 0.729351673915242 0.3 10.1 10 1 ALLOGRAFT REJECTION%KEGG%HSA05330 ALLOGRAFT REJECTION 0.550300002156277 0.667049261253142 0.720347332261968 0.296296296296296 10.1 10 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.525047665865416 0.637747901836528 0.712161567122627 0.292929292929293 10.1 10 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.575700551952119 0.692574067289114 0.709091905195374 0.291666666666667 10.1 10 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.544896429638992 0.66124799123701 0.707809641352345 0.291139240506329 10.1 10 1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK WNT SIGNALING NETWORK 0.597346584092143 0.71600133738681 0.69462064182404 0.285714285714286 10.1 10 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.624431640253394 0.74676926773161 0.68072822898756 0.28 10.1 10 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.624431640253394 0.74676926773161 0.68072822898756 0.28 10.1 10 1 PHOTOTRANSDUCTION%KEGG%HSA04744 PHOTOTRANSDUCTION 0.654924768459403 0.76114438714299 0.663046976286584 0.272727272727273 10.1 10 1 ST_GA12_PATHWAY%MSIGDB_C2%ST_GA12_PATHWAY ST_GA12_PATHWAY 0.654924768459403 0.76114438714299 0.663046976286584 0.272727272727273 10.1 10 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.654924768459403 0.76114438714299 0.663046976286584 0.272727272727273 10.1 10 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.654924768459403 0.76114438714299 0.663046976286584 0.272727272727273 10.1 10 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.654924768459403 0.76114438714299 0.663046976286584 0.272727272727273 10.1 10 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.657275407042687 0.763539756991879 0.663046976286584 0.272727272727273 10.1 10 1 BASAL CELL CARCINOMA%KEGG%HSA05217 BASAL CELL CARCINOMA 0.668937787101387 0.77435862361122 0.663046976286584 0.272727272727273 10.1 10 1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 CADHERIN SIGNALING PATHWAY 0.721280129408705 0.830574542030897 0.657073580103822 0.27027027027027 10.1 10 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.969130178621156 1 0.651170400165022 0.26784214945424 10.1 10 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.695562055671306 0.803063546762362 0.643545594631096 0.264705882352941 10.1 10 1 HEDGEHOG SIGNALING PATHWAY%KEGG%HSA04340 HEDGEHOG SIGNALING PATHWAY 0.717100333623353 0.826374994512779 0.642196442441094 0.264150943396226 10.1 10 1 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY 0.689747170227503 0.796698768239126 0.63978217010109 0.263157894736842 10.1 10 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.689747170227503 0.796698768239126 0.63978217010109 0.263157894736842 10.1 10 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.706848294700928 0.815023591222714 0.63978217010109 0.263157894736842 10.1 10 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.717319818900171 0.826374994512779 0.636735588338704 0.261904761904762 10.1 10 1 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY 0.701091496194597 0.808739403090617 0.634218846882819 0.260869565217391 10.1 10 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.701091496194597 0.808739403090617 0.634218846882819 0.260869565217391 10.1 10 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.731036016941471 0.835243490760251 0.625158577641636 0.257142857142857 10.1 10 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.739869325808957 0.844604074527367 0.623377499072857 0.256410256410256 10.1 10 1 COMPLEMENT AND COAGULATION CASCADES%KEGG%HSA04610 COMPLEMENT AND COAGULATION CASCADES 0.784194155984391 0.883348991597966 0.617440570510258 0.253968253968254 10.1 10 1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 SYNAPTIC_VESICLE_TRAFFICKING 0.73618429516785 0.840761362649468 0.607793061596035 0.25 10.1 10 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.749832111535288 0.846812538808803 0.607793061596035 0.25 10.1 10 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.846679674302212 0.929514696559089 0.600642554989023 0.247058823529412 10.1 10 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.846679674302212 0.929514696559089 0.600642554989023 0.247058823529412 10.1 10 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.99966587768238 1 0.600099478537858 0.246835443037975 10.1 10 1 MATURITY ONSET DIABETES OF THE YOUNG%KEGG%HSA04950 MATURITY ONSET DIABETES OF THE YOUNG 0.780295899931502 0.879333456461269 0.583481339132194 0.24 10.1 10 1 PRIMARY IMMUNODEFICIENCY%KEGG%HSA05340 PRIMARY IMMUNODEFICIENCY 0.817255804780114 0.908411099623562 0.572040528560974 0.235294117647059 10.1 10 1 AUTOIMMUNE THYROID DISEASE%KEGG%HSA05320 AUTOIMMUNE THYROID DISEASE 0.814917721206864 0.908411099623562 0.5672735241563 0.233333333333333 10.1 10 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.813425618704464 0.908411099623562 0.561039749165571 0.230769230769231 10.1 10 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.842802408584156 0.926415152745485 0.555696513459232 0.228571428571429 10.1 10 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.842114972762245 0.926415152745485 0.548974378215774 0.225806451612903 10.1 10 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.842114972762245 0.926415152745485 0.548974378215774 0.225806451612903 10.1 10 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.842114972762245 0.926415152745485 0.548974378215774 0.225806451612903 10.1 10 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.982061515750092 1 0.548974378215774 0.225806451612903 10.1 10 1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION 0.842487015570167 0.926415152745485 0.540260499196476 0.222222222222222 10.1 10 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.842487015570167 0.926415152745485 0.540260499196476 0.222222222222222 10.1 10 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.866008656590267 0.949943771808875 0.531818928896531 0.21875 10.1 10 1 PROTEIN EXPORT%KEGG%HSA03060 PROTEIN EXPORT 0.84447942039227 0.927871763156007 0.528515705735683 0.217391304347826 10.1 10 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.927310566530002 0.998853453326517 0.506494217996696 0.208333333333333 10.1 10 1 STEROID HORMONE BIOSYNTHESIS%KEGG%HSA00140 STEROID HORMONE BIOSYNTHESIS 0.928778190762655 0.999260746242807 0.497285232214938 0.204545454545455 10.1 10 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.893943373791513 0.969296330875091 0.486234449276828 0.2 10.1 10 1 METABOLISM OF XENOBIOTICS BY CYTOCHROME P450%KEGG%HSA00980 METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 0.962623185246244 1 0.467533124304642 0.192307692307692 10.1 10 1 RETINOL METABOLISM%KEGG%HSA00830 RETINOL METABOLISM 0.957470248416982 1 0.465543621648027 0.191489361702128 10.1 10 1 DRUG METABOLISM - CYTOCHROME P450%KEGG%HSA00982 DRUG METABOLISM - CYTOCHROME P450 0.968603301305683 1 0.458711744600781 0.188679245283019 10.1 10 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998011187309626 1 0.427706228530543 0.175925925925926 10.1 10 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.970030342980816 1 0.39212455586841 0.161290322580645 10.1 10 1 OLFACTORY TRANSDUCTION%KEGG%HSA04740 OLFACTORY TRANSDUCTION 0.999999995480771 1 0.362987522897632 0.149305555555556 10.1 10 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999666382737681 1 0.351169324477709 0.144444444444444 10.1 10 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.309778399136044 0.12741935483871 10.1 10 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 8.9438528142081e-06 4.92378702945027e-05 1.63385093167702 1 11.2 11 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 8.9438528142081e-06 4.92378702945027e-05 1.63385093167702 1 11.2 11 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 8.9438528142081e-06 4.92378702945027e-05 1.63385093167702 1 11.2 11 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 2.35692657151479e-05 0.000118837769963375 1.63385093167702 1 11.2 11 2 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7226 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 6.21078537267698e-05 0.000276652720063331 1.63385093167702 1 11.2 11 2 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7227 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 6.21078537267698e-05 0.000276652720063331 1.63385093167702 1 11.2 11 2 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY 6.21078537267698e-05 0.000276652720063331 1.63385093167702 1 11.2 11 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 6.21078537267698e-05 0.000276652720063331 1.63385093167702 1 11.2 11 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 6.21078537267698e-05 0.000276652720063331 1.63385093167702 1 11.2 11 2 BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY 0.000163653784410178 0.000648954931563367 1.63385093167702 1 11.2 11 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000163653784410178 0.000648954931563367 1.63385093167702 1 11.2 11 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000163653784410178 0.000648954931563367 1.63385093167702 1 11.2 11 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.000163653784410178 0.000648954931563367 1.63385093167702 1 11.2 11 2 SYNTHESIS AND DEGRADATION OF KETONE BODIES%KEGG%HSA00072 SYNTHESIS AND DEGRADATION OF KETONE BODIES 0.000431205853950869 0.00147324495857414 1.63385093167702 1 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.000431205853950869 0.00147324495857414 1.63385093167702 1 11.2 11 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.000431205853950869 0.00147324495857414 1.63385093167702 1 11.2 11 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000431205853950869 0.00147324495857414 1.63385093167702 1 11.2 11 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000431205853950869 0.00147324495857414 1.63385093167702 1 11.2 11 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.000431205853950869 0.00147324495857414 1.63385093167702 1 11.2 11 2 PENTOSE PHOSPHATE PATHWAY%HUMANCYC%PENTOSE-P-PWY PENTOSE PHOSPHATE PATHWAY 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00113611504299321 0.00337000603866491 1.63385093167702 1 11.2 11 2 LYSINE DEGRADATION II (PIPECOLATE PATHWAY)%HUMANCYC%PWY66-425 LYSINE DEGRADATION II (PIPECOLATE PATHWAY) 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 COENZYME A BIOSYNTHESIS%HUMANCYC%COA-PWY-1 COENZYME A BIOSYNTHESIS 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 GABA SHUNT%HUMANCYC%GLUDEG-I-PWY GABA SHUNT 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 &GAMMA;-GLUTAMYL CYCLE 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 CYANOAMINO ACID METABOLISM%KEGG%HSA00460 CYANOAMINO ACID METABOLISM 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY ALTERNATIVE NF-KAPPAB PATHWAY 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0029932227767783 0.00760417000227782 1.63385093167702 1 11.2 11 2 KETOGENESIS%HUMANCYC%REACT_1464.NULL KETOGENESIS 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 FATTY ACID &ALPHA;-OXIDATION%HUMANCYC%PWY66-387 FATTY ACID &ALPHA;-OXIDATION 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 ZYMOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6074 ZYMOSTEROL BIOSYNTHESIS 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 FOLATE POLYGLUTAMYLATION%HUMANCYC%PWY-2161 FOLATE POLYGLUTAMYLATION 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00788560181479947 0.0173286099880218 1.63385093167702 1 11.2 11 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 3.39376910867037e-06 2.10054885141024e-05 1.63385093167702 1 11.2 11 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.04362045282365e-08 1.98857089819039e-07 1.55958498023715 0.954545454545455 11.2 11 2 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 FORWARD SIGNALING 3.24722310664617e-07 2.51112238481699e-06 1.54785877737823 0.947368421052632 11.2 11 2 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-CADHERIN SIGNALING IN KERATINOCYTES 3.24722310664617e-07 2.51112238481699e-06 1.54785877737823 0.947368421052632 11.2 11 2 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY 8.1230238387359e-07 5.73511468299873e-06 1.54308143547274 0.944444444444444 11.2 11 2 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY 8.1230238387359e-07 5.73511468299873e-06 1.54308143547274 0.944444444444444 11.2 11 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 2.02603463130742e-06 1.34237520672303e-05 1.53774205334308 0.941176470588235 11.2 11 2 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY 5.0367765394477e-06 2.89999557522349e-05 1.5317352484472 0.9375 11.2 11 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.0367765394477e-06 2.89999557522349e-05 1.5317352484472 0.9375 11.2 11 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.0367765394477e-06 2.89999557522349e-05 1.5317352484472 0.9375 11.2 11 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 5.0367765394477e-06 2.89999557522349e-05 1.5317352484472 0.9375 11.2 11 2 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY 1.24755859465979e-05 6.60604822112021e-05 1.52492753623188 0.933333333333333 11.2 11 2 BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY 3.07725017499129e-05 0.00015055118203065 1.51714729370009 0.928571428571429 11.2 11 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 3.07725017499129e-05 0.00015055118203065 1.51714729370009 0.928571428571429 11.2 11 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 3.07725017499129e-05 0.00015055118203065 1.51714729370009 0.928571428571429 11.2 11 2 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 PATHWAY 4.2707666290488e-09 4.57805349626085e-08 1.51282493673798 0.925925925925926 11.2 11 2 TERPENOID BACKBONE BIOSYNTHESIS%KEGG%HSA00900 TERPENOID BACKBONE BIOSYNTHESIS 7.55448572806607e-05 0.000328732324503469 1.50817009077879 0.923076923076923 11.2 11 2 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY 7.55448572806607e-05 0.000328732324503469 1.50817009077879 0.923076923076923 11.2 11 2 BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY 2.5476111982856e-08 2.42528907215853e-07 1.50314285714286 0.92 11.2 11 2 SA_PROGRAMMED_CELL_DEATH%MSIGDB_C2%SA_PROGRAMMED_CELL_DEATH SA_PROGRAMMED_CELL_DEATH 0.000184448807625487 0.000716335059953473 1.4976966873706 0.916666666666667 11.2 11 2 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY 0.000184448807625487 0.000716335059953473 1.4976966873706 0.916666666666667 11.2 11 2 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY 0.000184448807625487 0.000716335059953473 1.4976966873706 0.916666666666667 11.2 11 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000184448807625487 0.000716335059953473 1.4976966873706 0.916666666666667 11.2 11 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.000184448807625487 0.000716335059953473 1.4976966873706 0.916666666666667 11.2 11 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000184448807625487 0.000716335059953473 1.4976966873706 0.916666666666667 11.2 11 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.50026884147028e-07 1.24409086004941e-06 1.49177693761815 0.91304347826087 11.2 11 2 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7176 UTP AND CTP DE NOVO< I> BIOSYNTHESIS 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%HUMANCYC%PWY-7224 PURINE DEOXYRIBONUCLEOSIDES SALVAGE 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 RIBOFLAVIN METABOLISM%KEGG%HSA00740 RIBOFLAVIN METABOLISM 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000447493733842988 0.00151481511700123 1.48531902879729 0.909090909090909 11.2 11 2 BIOSYNTHESIS OF UNSATURATED FATTY ACIDS%KEGG%HSA01040 BIOSYNTHESIS OF UNSATURATED FATTY ACIDS 2.08203107267691e-06 1.36236127509901e-05 1.47046583850932 0.9 11.2 11 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.08203107267691e-06 1.36236127509901e-05 1.47046583850932 0.9 11.2 11 2 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE) 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%HUMANCYC%PWY-7197 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 PYRIMIDINE METABOLISM 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00107756716056085 0.0032812293330242 1.47046583850932 0.9 11.2 11 2 BUTANOATE METABOLISM%KEGG%HSA00650 BUTANOATE METABOLISM 2.53505608351298e-08 2.42208075805207e-07 1.45879547471162 0.892857142857143 11.2 11 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.98511792148866e-08 5.3866061293398e-07 1.45231193926846 0.888888888888889 11.2 11 2 GLYCOGENOLYSIS%HUMANCYC%PWY-5941-1 GLYCOGENOLYSIS 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 HEME BIOSYNTHESIS%HUMANCYC%PWY-5920 HEME BIOSYNTHESIS 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 CMP PHOSPHORYLATION%HUMANCYC%PWY-7205 CMP PHOSPHORYLATION 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 FATTY ACID ELONGATION IN MITOCHONDRIA%KEGG%HSA00062 FATTY ACID ELONGATION IN MITOCHONDRIA 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 CIRCADIAN CLOCK SYSTEM 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 CHOLESTEROL BIOSYNTHESIS 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0025716224102764 0.00663538972201455 1.45231193926846 0.888888888888889 11.2 11 2 SELENOCOMPOUND METABOLISM%KEGG%HSA00450 SELENOCOMPOUND METABOLISM 2.76173408504998e-05 0.000137669050704666 1.44163317500913 0.882352941176471 11.2 11 2 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY 2.76173408504998e-05 0.000137669050704666 1.44163317500913 0.882352941176471 11.2 11 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.76173408504998e-05 0.000137669050704666 1.44163317500913 0.882352941176471 11.2 11 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.29264821421841e-07 2.53880507043683e-06 1.43778881987578 0.88 11.2 11 2 IFN-GAMMA%IOB%IFN-GAMMA IFN-GAMMA 1.22472906225914e-10 1.78431521391015e-09 1.42961956521739 0.875 11.2 11 2 BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY 7.66699773367486e-07 5.44956146191391e-06 1.42961956521739 0.875 11.2 11 2 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY 7.66699773367486e-07 5.44956146191391e-06 1.42961956521739 0.875 11.2 11 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.66699773367486e-07 5.44956146191391e-06 1.42961956521739 0.875 11.2 11 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.66699773367486e-07 5.44956146191391e-06 1.42961956521739 0.875 11.2 11 2 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY 6.45472517966495e-05 0.000285110725272638 1.42961956521739 0.875 11.2 11 2 SA_PTEN_PATHWAY%MSIGDB_C2%SA_PTEN_PATHWAY SA_PTEN_PATHWAY 6.45472517966495e-05 0.000285110725272638 1.42961956521739 0.875 11.2 11 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 6.45472517966495e-05 0.000285110725272638 1.42961956521739 0.875 11.2 11 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 6.45472517966495e-05 0.000285110725272638 1.42961956521739 0.875 11.2 11 2 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%HUMANCYC%PWY66-414 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 MEVALONATE PATHWAY%HUMANCYC%PWY-922 MEVALONATE PATHWAY 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK GLYPICAN 3 NETWORK 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00607047936628962 0.01409142085291 1.42961956521739 0.875 11.2 11 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.7756744438253e-06 1.18243775463821e-05 1.42073994058871 0.869565217391304 11.2 11 2 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%HUMANCYC%PWY-7200 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE 0.000149702454471459 0.000606056492650535 1.41600414078675 0.866666666666667 11.2 11 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000149702454471459 0.000606056492650535 1.41600414078675 0.866666666666667 11.2 11 2 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS 4.08837920362766e-06 2.43915293211903e-05 1.41105307735743 0.863636363636364 11.2 11 2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY 4.08837920362766e-06 2.43915293211903e-05 1.41105307735743 0.863636363636364 11.2 11 2 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL SIGNALING EVENTS MEDIATED BY PRL 4.08837920362766e-06 2.43915293211903e-05 1.41105307735743 0.863636363636364 11.2 11 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.43406727984611e-09 3.7575250692756e-08 1.40692719116632 0.861111111111111 11.2 11 2 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY NECTIN ADHESION PATHWAY 2.66854889493427e-07 2.12597082656848e-06 1.40044365572316 0.857142857142857 11.2 11 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.66854889493427e-07 2.12597082656848e-06 1.40044365572316 0.857142857142857 11.2 11 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 9.35301010568427e-06 5.1383099268103e-05 1.40044365572316 0.857142857142857 11.2 11 2 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7228 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.000344178990465149 0.00120852196785166 1.40044365572316 0.857142857142857 11.2 11 2 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%HUMANCYC%PWY-7210 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP 0.000344178990465149 0.00120852196785166 1.40044365572316 0.857142857142857 11.2 11 2 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING 0.000344178990465149 0.00120852196785166 1.40044365572316 0.857142857142857 11.2 11 2 SERINE AND GLYCINE BIOSYNTHESIS%HUMANCYC%SER-GLYSYN-PWY-1 SERINE AND GLYCINE BIOSYNTHESIS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 GDP-MANNOSE BIOSYNTHESIS%HUMANCYC%PWY-5659 GDP-MANNOSE BIOSYNTHESIS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 ADENOSINE NUCLEOTIDES DEGRADATION%HUMANCYC%SALVADEHYPOX-PWY ADENOSINE NUCLEOTIDES DEGRADATION 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 OLEATE BIOSYNTHESIS%HUMANCYC%PWY-5996 OLEATE BIOSYNTHESIS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 PYRUVATE METABOLISM 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0141358691794888 0.0285423330982481 1.40044365572316 0.857142857142857 11.2 11 2 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION 1.77469296949769e-08 1.73972689983845e-07 1.39357873584216 0.852941176470588 11.2 11 2 PEROXISOME%KEGG%HSA04146 PEROXISOME 7.20603629913654e-17 4.04304632357937e-15 1.39098119858989 0.851351351351351 11.2 11 2 LYSINE DEGRADATION%KEGG%HSA00310 LYSINE DEGRADATION 1.19528143006122e-09 1.45251480694536e-08 1.38877329192547 0.85 11.2 11 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.12467106291632e-05 0.000109003066009929 1.38877329192547 0.85 11.2 11 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.36634851988437e-06 9.27348686349883e-06 1.38248924988055 0.846153846153846 11.2 11 2 L-KYNURENINE DEGRADATION%HUMANCYC%PWY-6309 L-KYNURENINE DEGRADATION 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY ATYPICAL NF-KAPPAB PATHWAY 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000783420534522029 0.00246231221637019 1.38248924988055 0.846153846153846 11.2 11 2 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF SIGNALING PATHWAY 1.82234408333493e-10 2.61169638464903e-09 1.37969634230504 0.844444444444444 11.2 11 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.24432807566407e-11 2.62503450842092e-10 1.37756058945317 0.843137254901961 11.2 11 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.24432807566407e-11 2.62503450842092e-10 1.37756058945317 0.843137254901961 11.2 11 2 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY ARF1 PATHWAY 4.78914105021285e-05 0.000223521503529403 1.37587446878065 0.842105263157895 11.2 11 2 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT INSULIN-MEDIATED GLUCOSE TRANSPORT 3.0632332710821e-06 1.92327288948655e-05 1.3724347826087 0.84 11.2 11 2 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF RECEPTOR (ERBB1) SIGNALING PATHWAY 2.01082092174048e-07 1.6265444081686e-06 1.37032658785814 0.838709677419355 11.2 11 2 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY 1.34218977797374e-08 1.36654611757404e-07 1.36890213194561 0.837837837837838 11.2 11 2 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP SIGNALING EVENTS MEDIATED BY TCPTP 1.34218977797374e-08 1.36654611757404e-07 1.36890213194561 0.837837837837838 11.2 11 2 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY REGULATION OF ANDROGEN RECEPTOR ACTIVITY 6.17049212774402e-11 9.7434657130904e-10 1.36709975915832 0.836734693877551 11.2 11 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.17049212774402e-11 9.7434657130904e-10 1.36709975915832 0.836734693877551 11.2 11 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.08163496227188e-15 1.05535992149493e-13 1.36154244306418 0.833333333333333 11.2 11 2 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY 2.97739583288982e-08 2.81411928721522e-07 1.36154244306418 0.833333333333333 11.2 11 2 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-MEDIATED SIGNALING EVENTS 6.8205477961144e-06 3.82676266773483e-05 1.36154244306418 0.833333333333333 11.2 11 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000107024582049109 0.000453007741353933 1.36154244306418 0.833333333333333 11.2 11 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000107024582049109 0.000453007741353933 1.36154244306418 0.833333333333333 11.2 11 2 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL) 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 CHOLESTEROL BIOSYNTHESIS I 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL) 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0017627183649305 0.00486731762127929 1.36154244306418 0.833333333333333 11.2 11 2 GLYCINE BETAINE DEGRADATION%HUMANCYC%PWY-3661-1 GLYCINE BETAINE DEGRADATION 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%HUMANCYC%PWY3O-450 PHOSPHATIDYLCHOLINE BIOSYNTHESIS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%HUMANCYC%PWY-7209 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%HUMANCYC%PWY66-422 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY) 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 LEUKOTRIENE BIOSYNTHESIS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 FATTY ACID BIOSYNTHESIS%KEGG%HSA00061 FATTY ACID BIOSYNTHESIS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 VITAMIN B6 METABOLISM%KEGG%HSA00750 VITAMIN B6 METABOLISM 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 MRNA SPLICING%PANTHER PATHWAY%P00058 MRNA SPLICING 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 COENZYME A BIOSYNTHESIS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 VITAMIN D METABOLISM AND PATHWAY 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.0323474970049053 0.0577478979492615 1.36154244306418 0.833333333333333 11.2 11 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.46724834665944e-07 3.37539653012634e-06 1.36154244306418 0.833333333333333 11.2 11 2 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) 4.72010333709038e-16 2.4405710784132e-14 1.35800596918609 0.831168831168831 11.2 11 2 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ERBB4 SIGNALING EVENTS 6.57075191341509e-08 5.8735839985341e-07 1.35376220053239 0.828571428571429 11.2 11 2 PROPANOATE METABOLISM%KEGG%HSA00640 PROPANOATE METABOLISM 9.86408971386828e-07 6.80932056949493e-06 1.35215249518098 0.827586206896552 11.2 11 2 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 1.50737268126888e-05 7.85561612748228e-05 1.34970294355928 0.826086956521739 11.2 11 2 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY 1.50737268126888e-05 7.85561612748228e-05 1.34970294355928 0.826086956521739 11.2 11 2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC PATHWAY 1.50737268126888e-05 7.85561612748228e-05 1.34970294355928 0.826086956521739 11.2 11 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.50737268126888e-05 7.85561612748228e-05 1.34970294355928 0.826086956521739 11.2 11 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.46811868825003e-31 1.31085718008321e-28 1.34792701863354 0.825 11.2 11 2 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION 9.72836146688142e-09 1.00998776331363e-07 1.34792701863354 0.825 11.2 11 2 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) SIGNALING PATHWAY 1.44216302251281e-07 1.20729647313215e-06 1.34552429667519 0.823529411764706 11.2 11 2 PANTOTHENATE AND COA BIOSYNTHESIS%KEGG%HSA00770 PANTOTHENATE AND COA BIOSYNTHESIS 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000236886836212014 0.000891113533653468 1.34552429667519 0.823529411764706 11.2 11 2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES%MSIGDB_C2%SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 1.44776924456113e-09 1.73534886268532e-08 1.34338854382333 0.822222222222222 11.2 11 2 IL-7%NETPATH%IL-7 IL-7 2.16387636883221e-06 1.39856421191435e-05 1.34209183673469 0.821428571428571 11.2 11 2 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 INTERFERON-GAMMA SIGNALING PATHWAY 2.16387636883221e-06 1.39856421191435e-05 1.34209183673469 0.821428571428571 11.2 11 2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ERBB2 ERBB3 SIGNALING EVENTS 2.12551425928181e-08 2.05310663066891e-07 1.34059563624781 0.82051282051282 11.2 11 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.15199129402776e-09 3.52194959421661e-08 1.33678712591756 0.818181818181818 11.2 11 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.15199129402776e-09 3.52194959421661e-08 1.33678712591756 0.818181818181818 11.2 11 2 CIRCADIAN RHYTHM - MAMMAL%KEGG%HSA04710 CIRCADIAN RHYTHM - MAMMAL 3.30438491649393e-05 0.000159008449357564 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY 3.30438491649393e-05 0.000159008449357564 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY 3.30438491649393e-05 0.000159008449357564 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY 3.30438491649393e-05 0.000159008449357564 1.33678712591756 0.818181818181818 11.2 11 2 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL SIGNALING PATHWAY 3.30438491649393e-05 0.000159008449357564 1.33678712591756 0.818181818181818 11.2 11 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 3.30438491649393e-05 0.000159008449357564 1.33678712591756 0.818181818181818 11.2 11 2 FOLATE TRANSFORMATIONS%HUMANCYC%PWY-2201 FOLATE TRANSFORMATIONS 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7221 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 THROMBOPOIETIN%IOB%THROMBOPOIETIN THROMBOPOIETIN 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00391289758079123 0.00956284608020989 1.33678712591756 0.818181818181818 11.2 11 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.61971600509774e-08 4.20075555360095e-07 1.33287839163125 0.815789473684211 11.2 11 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.7136036169812e-06 2.76832354966134e-05 1.33128594432942 0.814814814814815 11.2 11 2 SIG_CD40PATHWAYMAP%MSIGDB_C2%SIG_CD40PATHWAYMAP SIG_CD40PATHWAYMAP 6.82449243192124e-07 4.93046206656885e-06 1.32750388198758 0.8125 11.2 11 2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000518708332728972 0.00169496142925192 1.32750388198758 0.8125 11.2 11 2 PYRUVATE METABOLISM%KEGG%HSA00620 PYRUVATE METABOLISM 9.98542178253018e-08 8.66169646070134e-07 1.32474399865704 0.810810810810811 11.2 11 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 9.98542178253018e-08 8.66169646070134e-07 1.32474399865704 0.810810810810811 11.2 11 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.41134906894481e-12 8.03189954893524e-11 1.32264123040521 0.80952380952381 11.2 11 2 BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY 7.17949378539483e-05 0.000316065527747682 1.32264123040521 0.80952380952381 11.2 11 2 ST_GAQ_PATHWAY%MSIGDB_C2%ST_GAQ_PATHWAY ST_GAQ_PATHWAY 1.01901492261126e-05 5.49517863175029e-05 1.31964882943144 0.807692307692308 11.2 11 2 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY 1.01901492261126e-05 5.49517863175029e-05 1.31964882943144 0.807692307692308 11.2 11 2 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY 1.01901492261126e-05 5.49517863175029e-05 1.31964882943144 0.807692307692308 11.2 11 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.01901492261126e-05 5.49517863175029e-05 1.31964882943144 0.807692307692308 11.2 11 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.01901492261126e-05 5.49517863175029e-05 1.31964882943144 0.807692307692308 11.2 11 2 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE 4.87169908498605e-11 8.68018276155961e-10 1.31854636591479 0.807017543859649 11.2 11 2 ST_GA13_PATHWAY%MSIGDB_C2%ST_GA13_PATHWAY ST_GA13_PATHWAY 1.47023626171552e-06 9.84013457396909e-06 1.31762171909437 0.806451612903226 11.2 11 2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY NONCANONICAL WNT SIGNALING PATHWAY 1.47023626171552e-06 9.84013457396909e-06 1.31762171909437 0.806451612903226 11.2 11 2 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO SIGNALING PATHWAY 1.47023626171552e-06 9.84013457396909e-06 1.31762171909437 0.806451612903226 11.2 11 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.14575128184484e-07 1.72510552750757e-06 1.31615769496204 0.805555555555556 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.15817559755042e-08 2.95323015983704e-07 1.31505074988638 0.804878048780488 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.15817559755042e-08 2.95323015983704e-07 1.31505074988638 0.804878048780488 11.2 11 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.67824062850837e-09 4.99454272768283e-08 1.31418444504456 0.804347826086957 11.2 11 2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 SIGNALING EVENTS 2.34724069240536e-12 5.67859973015866e-11 1.31203180877094 0.803030303030303 11.2 11 2 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 4.99078138216036e-12 1.14440786997886e-10 1.30708074534162 0.8 11.2 11 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 9.96887949189439e-09 1.03089942039708e-07 1.30708074534161 0.8 11.2 11 2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-GAMMA PATHWAY 6.73622670965648e-08 6.00115872748788e-07 1.30708074534161 0.8 11.2 11 2 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 INTERNALIZATION OF ERBB1 4.58251434719798e-07 3.4525972381603e-06 1.30708074534161 0.8 11.2 11 2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY 0.000154470209993989 0.000618115240901594 1.30708074534161 0.8 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000154470209993989 0.000618115240901594 1.30708074534161 0.8 11.2 11 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000154470209993989 0.000618115240901594 1.30708074534161 0.8 11.2 11 2 PURINE NUCLEOTIDES DEGRADATION%HUMANCYC%PWY-6353 PURINE NUCLEOTIDES DEGRADATION 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 TAURINE AND HYPOTAURINE METABOLISM%KEGG%HSA00430 TAURINE AND HYPOTAURINE METABOLISM 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00854784340913862 0.0185214980032034 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.32058271957438e-11 6.16646241656172e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) 1.48301899128122e-09 1.76158607207593e-08 1.30708074534161 0.8 11.2 11 2 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS NETRIN-MEDIATED SIGNALING EVENTS 3.14514551827035e-06 1.96069709968769e-05 1.30708074534161 0.8 11.2 11 2 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING AURORA A SIGNALING 3.14514551827035e-06 1.96069709968769e-05 1.30708074534161 0.8 11.2 11 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.14514551827035e-06 1.96069709968769e-05 1.30708074534161 0.8 11.2 11 2 CD40%IOB%CD40 CD40 2.18498058962436e-05 0.000110591052108243 1.30708074534161 0.8 11.2 11 2 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY 2.18498058962436e-05 0.000110591052108243 1.30708074534161 0.8 11.2 11 2 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY P38 MAPK SIGNALING PATHWAY 2.18498058962436e-05 0.000110591052108243 1.30708074534161 0.8 11.2 11 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.18498058962436e-05 0.000110591052108243 1.30708074534161 0.8 11.2 11 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.18498058962436e-05 0.000110591052108243 1.30708074534161 0.8 11.2 11 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.18498058962436e-05 0.000110591052108243 1.30708074534161 0.8 11.2 11 2 SA_G1_AND_S_PHASES%MSIGDB_C2%SA_G1_AND_S_PHASES SA_G1_AND_S_PHASES 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY ARF6 DOWNSTREAM PATHWAY 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0011220851344399 0.00335920269269304 1.30708074534161 0.8 11.2 11 2 NOTCH%IOB%NOTCH NOTCH 2.40341744452803e-13 6.53382659919629e-12 1.30266493201276 0.797297297297297 11.2 11 2 UBIQUITIN MEDIATED PROTEOLYSIS%KEGG%HSA04120 UBIQUITIN MEDIATED PROTEOLYSIS 5.0174638189143e-22 5.088866188645e-20 1.30197496118012 0.796875 11.2 11 2 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY P53 PATHWAY 4.69411377588839e-10 6.18918901350884e-09 1.30102944559466 0.796296296296296 11.2 11 2 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RHOA SIGNALING PATHWAY 2.11322304644223e-08 2.04873866671623e-07 1.29965415019763 0.795454545454545 11.2 11 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 1.42847477701345e-07 1.19964585572753e-06 1.29870202261507 0.794871794871795 11.2 11 2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT 9.72244827837375e-07 6.76466915833023e-06 1.29746985750822 0.794117647058823 11.2 11 2 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY 6.6775013923728e-06 3.7544927871401e-05 1.29581280788177 0.793103448275862 11.2 11 2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS OSTEOPONTIN-MEDIATED EVENTS 6.6775013923728e-06 3.7544927871401e-05 1.29581280788177 0.793103448275862 11.2 11 2 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING RETINOIC ACID RECEPTORS-MEDIATED SIGNALING 6.6775013923728e-06 3.7544927871401e-05 1.29581280788177 0.793103448275862 11.2 11 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.6775013923728e-06 3.7544927871401e-05 1.29581280788177 0.793103448275862 11.2 11 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.62783127034808e-09 6.99103642396316e-08 1.29346532091097 0.791666666666667 11.2 11 2 IL9%NETPATH%IL9 IL9 4.64358070756714e-05 0.000217884738894209 1.29346532091097 0.791666666666667 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.64358070756714e-05 0.000217884738894209 1.29346532091097 0.791666666666667 11.2 11 2 NOTCH%NETPATH%NOTCH NOTCH 1.06753245219205e-12 2.68103150136233e-11 1.29346532091097 0.791666666666667 11.2 11 2 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION%KEGG%HSA00280 VALINE, LEUCINE AND ISOLEUCINE DEGRADATION 4.45521517402773e-08 4.09352000484708e-07 1.29188213202369 0.790697674418605 11.2 11 2 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY REGULATION OF RHOA ACTIVITY 4.45521517402773e-08 4.09352000484708e-07 1.29188213202369 0.790697674418605 11.2 11 2 CDP-DIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%PWY-5667 CDP-DIACYLGLYCEROL BIOSYNTHESIS 0.000328773975350286 0.00116685999057699 1.28988231448186 0.789473684210526 11.2 11 2 CCR7%IOB%CCR7 CCR7 0.000328773975350286 0.00116685999057699 1.28988231448186 0.789473684210526 11.2 11 2 PROXIMAL TUBULE BICARBONATE RECLAMATION%KEGG%HSA04964 PROXIMAL TUBULE BICARBONATE RECLAMATION 0.000328773975350286 0.00116685999057699 1.28988231448186 0.789473684210526 11.2 11 2 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY 0.000328773975350286 0.00116685999057699 1.28988231448186 0.789473684210526 11.2 11 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000328773975350286 0.00116685999057699 1.28988231448186 0.789473684210526 11.2 11 2 ADHERENS JUNCTION%KEGG%HSA04520 ADHERENS JUNCTION 2.2380950651501e-12 5.46468211740817e-11 1.28867115737906 0.788732394366197 11.2 11 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.07403707198308e-13 3.18228736945999e-12 1.28665760869565 0.7875 11.2 11 2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FOXO FAMILY SIGNALING 1.39049848749844e-08 1.39952080592877e-07 1.2862230738734 0.787234042553192 11.2 11 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.39049848749844e-08 1.39952080592877e-07 1.2862230738734 0.787234042553192 11.2 11 2 EPO%IOB%EPO EPO 6.52135147229233e-10 8.47133193716004e-09 1.28374001774623 0.785714285714286 11.2 11 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.52135147229233e-10 8.47133193716004e-09 1.28374001774623 0.785714285714286 11.2 11 2 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY INSULIN PATHWAY 9.33893103446856e-08 8.20892037929786e-07 1.28374001774623 0.785714285714286 11.2 11 2 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY 1.40626035268609e-05 7.38706882476738e-05 1.28374001774623 0.785714285714286 11.2 11 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.40626035268609e-05 7.38706882476738e-05 1.28374001774623 0.785714285714286 11.2 11 2 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY-7184 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 SA_CASPASE_CASCADE%MSIGDB_C2%SA_CASPASE_CASCADE SA_CASPASE_CASCADE 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-MEDIATED SIGNALING EVENTS 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY CIRCADIAN RHYTHM PATHWAY 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 GENERAL TRANSCRIPTION BY RNA POLYMERASE I 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT SIGNALING PATHWAY 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 CELL CYCLE%PANTHER PATHWAY%P00013 CELL CYCLE 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00239397286273059 0.00633190214545693 1.28374001774623 0.785714285714286 11.2 11 2 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY 6.30438428236519e-07 4.59244788745773e-06 1.28058586536847 0.783783783783784 11.2 11 2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY 9.77362896330416e-05 0.00041672971550746 1.27866594652984 0.782608695652174 11.2 11 2 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY 9.77362896330416e-05 0.00041672971550746 1.27866594652984 0.782608695652174 11.2 11 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.28376132787051e-06 2.52713168268334e-05 1.27644604037267 0.78125 11.2 11 2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 KINASE PATHWAY 1.9458186219367e-07 1.57880729416833e-06 1.27520072716255 0.780487804878049 11.2 11 2 P53 SIGNALING PATHWAY%KEGG%HSA04115 P53 SIGNALING PATHWAY 4.24690262617531e-10 5.72758438608385e-09 1.27384987893462 0.779661016949153 11.2 11 2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES%MSIGDB_C2%SIG_IL4RECEPTOR_IN_B_LYPHOCYTES SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 2.93580588580725e-05 0.000144976032226099 1.2707729468599 0.777777777777778 11.2 11 2 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY 2.93580588580725e-05 0.000144976032226099 1.2707729468599 0.777777777777778 11.2 11 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 2.93580588580725e-05 0.000144976032226099 1.2707729468599 0.777777777777778 11.2 11 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 2.93580588580725e-05 0.000144976032226099 1.2707729468599 0.777777777777778 11.2 11 2 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN ALPHA6BETA4INTEGRIN 6.33506421050328e-12 1.41572579009298e-10 1.2707729468599 0.777777777777778 11.2 11 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 6.02039588682703e-08 5.39992651481731e-07 1.2707729468599 0.777777777777778 11.2 11 2 GDNF%IOB%GDNF GDNF 1.3111185075934e-06 8.95704534850722e-06 1.2707729468599 0.777777777777778 11.2 11 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.3111185075934e-06 8.95704534850722e-06 1.2707729468599 0.777777777777778 11.2 11 2 CCR9%IOB%CCR9 CCR9 0.000691404725782181 0.00221535147252444 1.2707729468599 0.777777777777778 11.2 11 2 GLYOXYLATE AND DICARBOXYLATE METABOLISM%KEGG%HSA00630 GLYOXYLATE AND DICARBOXYLATE METABOLISM 0.000691404725782181 0.00221535147252444 1.2707729468599 0.777777777777778 11.2 11 2 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY 0.000691404725782181 0.00221535147252444 1.2707729468599 0.777777777777778 11.2 11 2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN DEGRADATION OF BETA CATENIN 0.000691404725782181 0.00221535147252444 1.2707729468599 0.777777777777778 11.2 11 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000691404725782181 0.00221535147252444 1.2707729468599 0.777777777777778 11.2 11 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000691404725782181 0.00221535147252444 1.2707729468599 0.777777777777778 11.2 11 2 TRYPTOPHAN DEGRADATION%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 TRYPTOPHAN DEGRADATION 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 SULFUR RELAY SYSTEM%KEGG%HSA04122 SULFUR RELAY SYSTEM 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 SALVAGE PYRIMIDINE RIBONUCLEOTIDES 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA CYCLE 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0183164787123359 0.0361531095542139 1.2707729468599 0.777777777777778 11.2 11 2 TSH%NETPATH%TSH TSH 1.99046390273639e-12 4.90547038459427e-11 1.26838427590716 0.776315789473684 11.2 11 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.99046390273639e-12 4.90547038459427e-11 1.26838427590716 0.776315789473684 11.2 11 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.77370647713565e-10 1.09133320661352e-08 1.26764296423217 0.775862068965517 11.2 11 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.77370647713565e-10 1.09133320661352e-08 1.26764296423217 0.775862068965517 11.2 11 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.02852092006696e-07 3.0614437078434e-06 1.26623447204969 0.775 11.2 11 2 FAS%IOB%FAS FAS 2.22353261312426e-17 1.43011109775822e-15 1.26586648760562 0.774774774774775 11.2 11 2 ALANINE, ASPARTATE AND GLUTAMATE METABOLISM%KEGG%HSA00250 ALANINE, ASPARTATE AND GLUTAMATE METABOLISM 8.88769154074403e-06 4.92370642708865e-05 1.26491685033059 0.774193548387097 11.2 11 2 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY 8.88769154074403e-06 4.92370642708865e-05 1.26491685033059 0.774193548387097 11.2 11 2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS SIGNALING PATHWAY 8.88769154074403e-06 4.92370642708865e-05 1.26491685033059 0.774193548387097 11.2 11 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.24179884078183e-07 1.04955882793003e-06 1.2625211744777 0.772727272727273 11.2 11 2 NITROGEN METABOLISM%KEGG%HSA00910 NITROGEN METABOLISM 0.00020354863939658 0.00078130678615543 1.2625211744777 0.772727272727273 11.2 11 2 SA_B_CELL_RECEPTOR_COMPLEXES%MSIGDB_C2%SA_B_CELL_RECEPTOR_COMPLEXES SA_B_CELL_RECEPTOR_COMPLEXES 0.00020354863939658 0.00078130678615543 1.2625211744777 0.772727272727273 11.2 11 2 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY 0.00020354863939658 0.00078130678615543 1.2625211744777 0.772727272727273 11.2 11 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00020354863939658 0.00078130678615543 1.2625211744777 0.772727272727273 11.2 11 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00020354863939658 0.00078130678615543 1.2625211744777 0.772727272727273 11.2 11 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00020354863939658 0.00078130678615543 1.2625211744777 0.772727272727273 11.2 11 2 SHIGELLOSIS%KEGG%HSA05131 SHIGELLOSIS 1.80400925904756e-09 2.09567066788917e-08 1.26121826304893 0.771929824561403 11.2 11 2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY COREGULATION OF ANDROGEN RECEPTOR ACTIVITY 1.80400925904756e-09 2.09567066788917e-08 1.26121826304893 0.771929824561403 11.2 11 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.7069725296092e-06 1.7118193190838e-05 1.26039929015084 0.771428571428571 11.2 11 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.7069725296092e-06 1.7118193190838e-05 1.26039929015084 0.771428571428571 11.2 11 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.7069725296092e-06 1.7118193190838e-05 1.26039929015084 0.771428571428571 11.2 11 2 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-BETA RECEPTOR SIGNALING 3.83826833633066e-08 3.55140828172069e-07 1.25942675983437 0.770833333333333 11.2 11 2 BIOCARTA_CHREBP2_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP2_PATHWAY BIOCARTA_CHREBP2_PATHWAY 8.28470540404598e-07 5.82580484012514e-06 1.25680840898232 0.769230769230769 11.2 11 2 EGFR1%IOB%EGFR1 EGFR1 2.93611670888084e-63 1.93563494032969e-60 1.25680840898232 0.769230769230769 11.2 11 2 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 SPECIFIC SIGNALS 6.07153281300142e-05 0.00027276475713434 1.25680840898232 0.769230769230769 11.2 11 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 6.07153281300142e-05 0.00027276475713434 1.25680840898232 0.769230769230769 11.2 11 2 STEARATE BIOSYNTHESIS%HUMANCYC%PWY-5972 STEARATE BIOSYNTHESIS 0.00502704446629208 0.0119318778196329 1.25680840898232 0.769230769230769 11.2 11 2 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY 0.00502704446629208 0.0119318778196329 1.25680840898232 0.769230769230769 11.2 11 2 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 HYPOXIA RESPONSE VIA HIF ACTIVATION 0.00502704446629208 0.0119318778196329 1.25680840898232 0.769230769230769 11.2 11 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00502704446629208 0.0119318778196329 1.25680840898232 0.769230769230769 11.2 11 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00502704446629208 0.0119318778196329 1.25680840898232 0.769230769230769 11.2 11 2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_BETA_RECEPTOR 2.51354753474681e-27 4.73444632080524e-25 1.25613270553663 0.768817204301075 11.2 11 2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-BETA SIGNALING PATHWAY 2.92244088486182e-18 2.14068794816128e-16 1.2557697243468 0.768595041322314 11.2 11 2 SMALL CELL LUNG CANCER%KEGG%HSA05222 SMALL CELL LUNG CANCER 8.23464198455092e-13 2.08795681858277e-11 1.25527571580064 0.768292682926829 11.2 11 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 8.93018940431888e-10 1.25498694752003 0.768115942028985 11.2 11 2 ST_FAS_SIGNALING_PATHWAY%MSIGDB_C2%ST_FAS_SIGNALING_PATHWAY ST_FAS_SIGNALING_PATHWAY 3.69113743896894e-09 4.00556766525148e-08 1.254564108252 0.767857142857143 11.2 11 2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY 1.82838135501382e-05 9.49102683695164e-05 1.25261904761905 0.766666666666667 11.2 11 2 EGFR1%NETPATH%EGFR1 EGFR1 2.04827966899213e-63 1.80043782904408e-60 1.25069119991205 0.765486725663717 11.2 11 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.42535355481275e-08 2.32569357237862e-07 1.24941541834125 0.764705882352941 11.2 11 2 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00143462819640908 0.00407599120852803 1.24941541834125 0.764705882352941 11.2 11 2 TNFALPHA%NETPATH%TNFALPHA TNFALPHA 2.31703768767575e-36 7.6375354780012e-34 1.24755284317974 0.763565891472868 11.2 11 2 PYRIMIDINE METABOLISM%KEGG%HSA00240 PYRIMIDINE METABOLISM 5.16177019146612e-14 1.6013632935172e-12 1.24734856074267 0.763440860215054 11.2 11 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.33241474266511e-09 2.66258773870472e-08 1.24615749026213 0.76271186440678 11.2 11 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.33241474266511e-09 2.66258773870472e-08 1.24615749026213 0.76271186440678 11.2 11 2 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING PRESENILIN ACTION IN NOTCH AND WNT SIGNALING 5.18398028110416e-07 3.86162598905979e-06 1.24483880508725 0.761904761904762 11.2 11 2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING INTEGRIN-LINKED KINASE SIGNALING 5.18398028110416e-07 3.86162598905979e-06 1.24483880508725 0.761904761904762 11.2 11 2 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000419031080842119 0.00144631539290663 1.24483880508725 0.761904761904762 11.2 11 2 RAS PATHWAY%PANTHER PATHWAY%P04393 RAS PATHWAY 2.25836826355061e-10 3.15096143438252e-09 1.24367757485863 0.761194029850746 11.2 11 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.25836826355061e-10 3.15096143438252e-09 1.24367757485863 0.761194029850746 11.2 11 2 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK NOTCH-MEDIATED HES HEY NETWORK 1.59440984448864e-07 1.31389336247392e-06 1.24314744801512 0.760869565217391 11.2 11 2 FSH%NETPATH%FSH FSH 1.59440984448864e-07 1.31389336247392e-06 1.24314744801512 0.760869565217391 11.2 11 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.04143241717975e-11 1.10525340976804e-09 1.24264718747266 0.76056338028169 11.2 11 2 TRAIL%IOB%TRAIL TRAIL 4.91892434612722e-08 4.45745824767611e-07 1.24172670807453 0.76 11.2 11 2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY REELIN SIGNALING PATHWAY 0.000124291477477193 0.000521905455584963 1.24172670807453 0.76 11.2 11 2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III SIGNALING EVENTS MEDIATED BY HDAC CLASS III 0.000124291477477193 0.000521905455584963 1.24172670807453 0.76 11.2 11 2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR 0.000124291477477193 0.000521905455584963 1.24172670807453 0.76 11.2 11 2 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES%MSIGDB_C2%SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES SIG_PIP3_SIGNALING_IN_CARDI