term p.value Adjusted.p.value fold_change gene_coverage subcluster cluster subset_cluster decreased atrioventricular cushion size 0.000381315423762376 0.164354007169681 6.54500061899063 0.454545454545455 1.2 1 2 abnormal aerobic respiration 0.000700415696384751 0.231763982429525 4.79966712059313 0.333333333333333 1.2 1 2 liver vascular congestion 0.001990677089537 0.330120617348219 4.79966712059313 0.333333333333333 1.2 1 2 vasculature congestion 0.00274181294333245 0.349756907514845 4.49968792555606 0.3125 1.2 1 2 abnormal optic stalk morphology 0.00130697991646728 0.280025971871635 4.31970040853382 0.3 1.2 1 2 abnormal touch/ nociception 0.00367840678249935 0.397827690063789 4.23500040052335 0.294117647058824 1.2 1 2 abnormal heart shape 0.00482378796946651 0.413764571518895 3.99972260049428 0.277777777777778 1.2 1 2 increased effector memory CD8-positive, alpha-beta T cell number 0.00482378796946651 0.413764571518895 3.99972260049428 0.277777777777778 1.2 1 2 pulmonary vascular congestion 0.00224926997809457 0.339094489121834 3.92700037139438 0.272727272727273 1.2 1 2 short humerus 4.33133235276758e-05 0.0528004363317837 3.86314670681886 0.268292682926829 1.2 1 2 abnormal pain threshold 0.000502345869256281 0.192243899965384 3.83973369647451 0.266666666666667 1.2 1 2 abnormal dopamine level 0.00783228082964818 0.518158872725382 3.59975034044485 0.25 1.2 1 2 shortened head 0.00170050920568095 0.313334566602324 3.59975034044485 0.25 1.2 1 2 decreased oocyte number 6.52909894816774e-05 0.0528004363317837 3.45576032682705 0.24 1.2 1 2 abnormal nest building behavior 0.00451574969553075 0.413764571518895 3.45576032682705 0.24 1.2 1 2 abnormal vertebrae development 0.00451574969553075 0.413764571518895 3.45576032682705 0.24 1.2 1 2 abnormal hair cycle 0.00260886209735229 0.341554971955991 3.35976698441519 0.233333333333333 1.2 1 2 abnormal synaptic transmission 0.00260886209735229 0.341554971955991 3.35976698441519 0.233333333333333 1.2 1 2 cleft upper lip 0.0119421705806135 0.595962830367755 3.27250030949532 0.227272727272727 1.2 1 2 increased circulating creatine kinase level 0.0119421705806135 0.595962830367755 3.27250030949532 0.227272727272727 1.2 1 2 increased adenoma incidence 0.0119421705806135 0.595962830367755 3.27250030949532 0.227272727272727 1.2 1 2 abnormal nose morphology 0.00318345551087104 0.377087884918653 3.25138740427277 0.225806451612903 1.2 1 2 short ulna 0.00106061043158052 0.251263661767289 3.16075639648816 0.219512195121951 1.2 1 2 abnormal respiratory electron transport chain 0.00220829047680354 0.339094489121834 3.11329759173608 0.216216216216216 1.2 1 2 premature aging 0.00813152984003005 0.518645653258327 3.08550029180987 0.214285714285714 1.2 1 2 abnormal inner cell mass apoptosis 0.0173104549511504 0.678106404582466 2.99979195037071 0.208333333333333 1.2 1 2 abnormal truncus arteriosus septation 0.0173104549511504 0.678106404582466 2.99979195037071 0.208333333333333 1.2 1 2 short sternum 0.0097004484998301 0.561159666123892 2.97910373002332 0.206896551724138 1.2 1 2 increased B cell derived lymphoma incidence 0.00122395819854945 0.276781456262887 2.87980027235588 0.2 1.2 1 2 short radius 0.00761259856521203 0.518158872725382 2.79980582034599 0.194444444444444 1.2 1 2 small cranium 0.0134629186019484 0.637885905187553 2.78690348937666 0.193548387096774 1.2 1 2 pulmonary edema 0.0240701731635767 0.700287201688854 2.76903872341911 0.192307692307692 1.2 1 2 abnormal pancreas morphology 0.00506115020897774 0.419653704827738 2.74266692605322 0.19047619047619 1.2 1 2 abnormal hair follicle development 0.00887360378584068 0.525549748030445 2.72413539276907 0.189189189189189 1.2 1 2 osteoporosis 0.0067754681408699 0.50310379105713 2.61800024759625 0.181818181818182 1.2 1 2 increased cardiomyocyte apoptosis 0.0181401298496663 0.692214877656388 2.61800024759625 0.181818181818182 1.2 1 2 single kidney 0.0181401298496663 0.692214877656388 2.61800024759625 0.181818181818182 1.2 1 2 abnormal ovulation 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 absent corpus callosum 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 increased bone resorption 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 abnormal mitotic spindle morphology 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 increased susceptibility to weight gain 0.020850141336419 0.692214877656388 2.54100024031401 0.176470588235294 1.2 1 2 decreased brain weight 0.00340536199569716 0.385038089286213 2.52614058978586 0.175438596491228 1.2 1 2 abnormal locomotor behavior 0.000268388408054321 0.133523233007025 2.50417414987468 0.173913043478261 1.2 1 2 increased mortality induced by gamma-irradiation 0.0370399982168438 0.842726407892208 2.4825864416861 0.172413793103448 1.2 1 2 abnormal liver development 0.0238214230670568 0.697126939756516 2.4684002334479 0.171428571428571 1.2 1 2 impaired behavioral response to xenobiotic 0.0238214230670568 0.697126939756516 2.4684002334479 0.171428571428571 1.2 1 2 impaired adaptive thermogenesis 0.0238214230670568 0.697126939756516 2.4684002334479 0.171428571428571 1.2 1 2 Leydig cell hyperplasia 0.0154726504531838 0.678106404582466 2.45836608615746 0.170731707317073 1.2 1 2 muscular ventricular septal defect 0.00498505705021879 0.419653704827738 2.39983356029657 0.166666666666667 1.2 1 2 abnormal locomotor activation 0.000740592428412282 0.231763982429525 2.37346176293067 0.164835164835165 1.2 1 2 abnormal contextual conditioning behavior 0.00851409257581269 0.525549748030445 2.35620022283663 0.163636363636364 1.2 1 2 abnormal double-strand DNA break repair 0.0198268466682935 0.692214877656388 2.34402347749897 0.162790697674419 1.2 1 2 abnormal cranial ganglia morphology 0.0476707154243869 0.842726407892208 2.32241957448055 0.161290322580645 1.2 1 2 increased neuron apoptosis 0.00208571640157336 0.334723841865402 2.31095083584114 0.160493827160494 1.2 1 2 microcephaly 0.00470049815048082 0.413764571518895 2.29549297071845 0.159420289855072 1.2 1 2 embryonic lethality, incomplete penetrance 0.022296026389698 0.692214877656388 2.29075021664672 0.159090909090909 1.2 1 2 decreased birth body size 0.000396431776087672 0.164354007169681 2.27352653080727 0.157894736842105 1.2 1 2 impaired branching involved in ureteric bud morphogenesis 0.034390492423126 0.842726407892208 2.27352653080727 0.157894736842105 1.2 1 2 dehydration 0.00525677320404917 0.428728634264666 2.2627002139939 0.157142857142857 1.2 1 2 abnormal cued conditioning behavior 0.016321135903873 0.678106404582466 2.25866688027912 0.156862745098039 1.2 1 2 failure of chorioallantoic fusion 0.016321135903873 0.678106404582466 2.25866688027912 0.156862745098039 1.2 1 2 abnormal tooth morphology 0.00792396869363544 0.518158872725382 2.24984396277803 0.15625 1.2 1 2 abnormal long term potentiation 0.0535946750330421 0.842726407892208 2.24984396277803 0.15625 1.2 1 2 abnormal auditory brainstem response waveform shape 0.0535946750330421 0.842726407892208 2.24984396277803 0.15625 1.2 1 2 oxidative stress 0.00194361643612098 0.330120617348219 2.23984465627679 0.155555555555556 1.2 1 2 abnormal brain morphology 4.38379639936213e-05 0.0528004363317837 2.23586977667382 0.15527950310559 1.2 1 2 eyelids open at birth 0.0182227693165858 0.692214877656388 2.21523097873529 0.153846153846154 1.2 1 2 atrial septal defect 0.0278548690722231 0.768854994110583 2.19115238114034 0.152173913043478 1.2 1 2 reduced long term potentiation 0.000898649421066691 0.248376714989266 2.18556270669866 0.151785714285714 1.2 1 2 decreased brown adipose tissue amount 0.0599258438157877 0.842726407892208 2.18166687299688 0.151515151515152 1.2 1 2 dilated heart atrium 0.0599258438157877 0.842726407892208 2.18166687299688 0.151515151515152 1.2 1 2 increased osteoblast cell number 0.0599258438157877 0.842726407892208 2.18166687299688 0.151515151515152 1.2 1 2 abnormal coat/ hair morphology 0.0202778119371406 0.692214877656388 2.17343416781576 0.150943396226415 1.2 1 2 abnormal kidney development 0.0148311881687451 0.678106404582466 2.15985020426691 0.15 1.2 1 2 abnormal skin pigmentation 0.0428870852081271 0.842726407892208 2.15985020426691 0.15 1.2 1 2 abnormal femur morphology 0.0108888989671862 0.595962830367755 2.1491046808626 0.149253731343284 1.2 1 2 kidney cysts 0.0080197453668049 0.518158872725382 2.14039209431856 0.148648648648649 1.2 1 2 limb grasping 5.03601400414074e-05 0.0528004363317837 2.1361155866376 0.148351648351648 1.2 1 2 decreased heart weight 0.00592226265865757 0.460363386356585 2.13318538693028 0.148148148148148 1.2 1 2 axon degeneration 0.022492136036749 0.692214877656388 2.13318538693028 0.148148148148148 1.2 1 2 lung hemorrhage 0.0666630338984375 0.842726407892208 2.11750020026167 0.147058823529412 1.2 1 2 abnormal brown adipose tissue morphology 0.0666630338984375 0.842726407892208 2.11750020026167 0.147058823529412 1.2 1 2 abnormal osteoclast morphology 0.0342839845754439 0.842726407892208 2.09985436525949 0.145833333333333 1.2 1 2 abnormal joint morphology 0.0248713774769084 0.719390133416393 2.094400198077 0.145454545454545 1.2 1 2 perimembraneous ventricular septal defect 0.0132881369733518 0.635658475407937 2.08681179156223 0.144927536231884 1.2 1 2 abnormal nervous system electrophysiology 0.00791813704178408 0.518158872725382 2.05700019453991 0.142857142857143 1.2 1 2 absent kidney 0.0378390500710796 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 skin edema 0.0525919946101327 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 increased T cell derived lymphoma incidence 0.0378390500710796 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 abnormal reproductive system morphology 0.0525919946101327 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 abnormal artery morphology 0.0738033023703342 0.871438061180357 2.05700019453991 0.142857142857143 1.2 1 2 abnormal cornea morphology 0.0117959659710197 0.595962830367755 2.03062839717402 0.141025641025641 1.2 1 2 incomplete embryo turning 0.0301458193268025 0.808201246875771 2.02091247182869 0.140350877192982 1.2 1 2 abnormal facial morphology 0.0301458193268025 0.808201246875771 2.02091247182869 0.140350877192982 1.2 1 2 abnormal interventricular septum morphology 0.041627550935733 0.842726407892208 2.01586019064911 0.14 1.2 1 2 abnormal hindlimb morphology 0.041627550935733 0.842726407892208 2.01586019064911 0.14 1.2 1 2 increased body length 0.041627550935733 0.842726407892208 2.01586019064911 0.14 1.2 1 2 increased oxygen consumption 0.00951722236663024 0.55703742675277 2.0091629807134 0.13953488372093 1.2 1 2 decreased oxygen consumption 0.0579052618439445 0.842726407892208 2.0091629807134 0.13953488372093 1.2 1 2 heart right ventricle hypertrophy 0.0813420304998356 0.930291038475131 1.99986130024714 0.138888888888889 1.2 1 2 reduced long term depression 0.0813420304998356 0.930291038475131 1.99986130024714 0.138888888888889 1.2 1 2 abnormal lysosome morphology 0.0813420304998356 0.930291038475131 1.99986130024714 0.138888888888889 1.2 1 2 abnormal response to novel object 0.0456535715089835 0.842726407892208 1.97633352024423 0.137254901960784 1.2 1 2 increased kidney weight 0.0456535715089835 0.842726407892208 1.97633352024423 0.137254901960784 1.2 1 2 astrocytosis 0.0192461563697788 0.692214877656388 1.97246593996978 0.136986301369863 1.2 1 2 reduced fertility 0.00167677774782072 0.313334566602324 1.96820881923603 0.136690647482014 1.2 1 2 abnormal astrocyte morphology 0.0635277727051413 0.842726407892208 1.96350018569719 0.136363636363636 1.2 1 2 increased erythroid progenitor cell number 0.0892730114142267 0.96396048807612 1.94581099483505 0.135135135135135 1.2 1 2 abnormal humerus morphology 0.0892730114142267 0.96396048807612 1.94581099483505 0.135135135135135 1.2 1 2 distended pericardium 0.0499205851833563 0.842726407892208 1.93832710639338 0.134615384615385 1.2 1 2 abnormal hair growth 0.0499205851833563 0.842726407892208 1.93832710639338 0.134615384615385 1.2 1 2 abnormal neurocranium morphology 0.0228679112343011 0.692214877656388 1.91986684823725 0.133333333333333 1.2 1 2 abnormal cell migration 0.0694597744239324 0.842726407892208 1.91986684823725 0.133333333333333 1.2 1 2 abnormal heart development 0.00141457869065414 0.281501159440174 1.9137913202365 0.132911392405063 1.2 1 2 polydactyly 0.0108000513777357 0.595962830367755 1.91007160921563 0.13265306122449 1.2 1 2 decreased grip strength 0.000211968191511866 0.117171305863504 1.90671707530412 0.132420091324201 1.2 1 2 ventricular septal defect 0.00312709797095047 0.377087884918653 1.90575018023551 0.132352941176471 1.2 1 2 pericardial edema 0.0312489669318515 0.808201246875771 1.90575018023551 0.132352941176471 1.2 1 2 decreased hair follicle number 0.0975885445946966 0.982978901917165 1.89460544233939 0.131578947368421 1.2 1 2 incomplete somite formation 0.0975885445946966 0.982978901917165 1.89460544233939 0.131578947368421 1.2 1 2 hyporesponsive to tactile stimuli 0.0975885445946966 0.982978901917165 1.89460544233939 0.131578947368421 1.2 1 2 abnormal kidney morphology 0.00100742017285972 0.250595767998856 1.89244017897672 0.131428571428571 1.2 1 2 abnormal maternal nurturing 0.042889703152226 0.842726407892208 1.88839362121697 0.131147540983607 1.2 1 2 decreased spleen weight 0.0339430914256264 0.842726407892208 1.87813061240601 0.130434782608696 1.2 1 2 abnormal forelimb morphology 0.0757005102266888 0.884061122952527 1.87813061240601 0.130434782608696 1.2 1 2 abnormal vitelline vasculature morphology 0.00756334838146175 0.518158872725382 1.87813061240601 0.130434782608696 1.2 1 2 abnormal nervous system physiology 0.00756334838146175 0.518158872725382 1.87813061240601 0.130434782608696 1.2 1 2 impaired limb coordination 0.0591883598883874 0.842726407892208 1.866537213564 0.12962962962963 1.2 1 2 abnormal apoptosis 0.0591883598883874 0.842726407892208 1.866537213564 0.12962962962963 1.2 1 2 decreased startle reflex 0.00883393540823341 0.525549748030445 1.84602581561274 0.128205128205128 1.2 1 2 absent gastric milk in neonates 0.0291880193353004 0.793499432749286 1.84602581561274 0.128205128205128 1.2 1 2 abnormal iris morphology 0.106279535656478 0.982978901917165 1.84602581561274 0.128205128205128 1.2 1 2 increased circulating creatinine level 0.0232276245073612 0.692214877656388 1.84173273232062 0.127906976744186 1.2 1 2 abnormal tibia morphology 0.0822482421489001 0.936350125150522 1.83817038661013 0.127659574468085 1.2 1 2 abnormal cell nucleus morphology 0.0822482421489001 0.936350125150522 1.83817038661013 0.127659574468085 1.2 1 2 decreased liver weight 0.0398022161355774 0.842726407892208 1.8252255247326 0.126760563380282 1.2 1 2 embryonic lethality, complete penetrance 5.32089673539954e-05 0.0528004363317837 1.80551741213535 0.125391849529781 1.2 1 2 abnormal digit morphology 0.0429737096509358 0.842726407892208 1.79987517022242 0.125 1.2 1 2 hydrops fetalis 0.0429737096509358 0.842726407892208 1.79987517022242 0.125 1.2 1 2 impaired ovarian folliculogenesis 0.115335600006242 0.982978901917165 1.79987517022242 0.125 1.2 1 2 short mandible 0.0694460641261928 0.842726407892208 1.79987517022242 0.125 1.2 1 2 perinatal lethality, incomplete penetrance 0.000791957326894859 0.231763982429525 1.7839470713709 0.123893805309735 1.2 1 2 increased bone trabecula number 0.12474516909118 0.982978901917165 1.75597577582676 0.121951219512195 1.2 1 2 hydroencephaly 0.0170727718320484 0.678106404582466 1.75292190491227 0.121739130434783 1.2 1 2 impaired coordination 7.42920712206001e-05 0.0528004363317837 1.74785565663218 0.121387283236994 1.2 1 2 abnormal neuron morphology 0.0267413188238521 0.747404837913845 1.7453334983975 0.121212121212121 1.2 1 2 pale yolk sac 0.0423108186962402 0.842726407892208 1.73481944117824 0.120481927710843 1.2 1 2 kyphosis 0.00870955378746082 0.525549748030445 1.72788016341353 0.12 1.2 1 2 short stride length 0.103701934594489 0.982978901917165 1.72788016341353 0.12 1.2 1 2 abnormal digestive system physiology 0.103701934594489 0.982978901917165 1.72788016341353 0.12 1.2 1 2 abnormal circulating protein level 0.103701934594489 0.982978901917165 1.72788016341353 0.12 1.2 1 2 abnormal cytotoxic T cell physiology 0.134495598075106 1 1.71416682878326 0.119047619047619 1.2 1 2 ataxia 0.0031370643940606 0.377087884918653 1.71077243902329 0.118811881188119 1.2 1 2 syndactyly 0.0866969087741557 0.96396048807612 1.70835609377044 0.11864406779661 1.2 1 2 hyperactivity 8.75957922488845e-05 0.054473633304775 1.70769827471238 0.118598382749326 1.2 1 2 abnormal axial skeleton morphology 0.0573361866828116 0.842726407892208 1.70514489810545 0.118421052631579 1.2 1 2 abnormal cervical vertebrae morphology 0.111441716339223 0.982978901917165 1.69400016020934 0.117647058823529 1.2 1 2 abnormal blood vessel morphology 0.0131580257377767 0.635545417916883 1.68815878034655 0.117241379310345 1.2 1 2 increased erythrocyte cell number 0.0929411725515617 0.968436157929962 1.6798834922076 0.116666666666667 1.2 1 2 reduced female fertility 0.00243179529686835 0.341554971955991 1.67574584813812 0.116379310344828 1.2 1 2 abnormal organ of Corti morphology 0.144573273894995 1 1.67430248392784 0.116279069767442 1.2 1 2 abnormal intestinal mucosa morphology 0.144573273894995 1 1.67430248392784 0.116279069767442 1.2 1 2 respiratory distress 0.00885590971946037 0.525549748030445 1.66462443488779 0.115606936416185 1.2 1 2 abnormal excitatory postsynaptic currents 0.0655527205057901 0.842726407892208 1.66142323405147 0.115384615384615 1.2 1 2 abnormal heart ventricle morphology 0.0655527205057901 0.842726407892208 1.66142323405147 0.115384615384615 1.2 1 2 decreased kidney weight 0.119466211707379 0.982978901917165 1.66142323405147 0.115384615384615 1.2 1 2 abnormal brain wave pattern 0.119466211707379 0.982978901917165 1.66142323405147 0.115384615384615 1.2 1 2 increased percent body fat/body weight 0.119466211707379 0.982978901917165 1.66142323405147 0.115384615384615 1.2 1 2 prenatal lethality, incomplete penetrance 0.000751369518911175 0.231763982429525 1.65777976204697 0.115131578947368 1.2 1 2 abnormal long bone morphology 0.0994293259922163 0.982978901917165 1.65234441856485 0.114754098360656 1.2 1 2 increased osteoclast cell number 0.0994293259922163 0.982978901917165 1.65234441856485 0.114754098360656 1.2 1 2 cleft palate 0.0230840926967215 0.692214877656388 1.64874061394421 0.114503816793893 1.2 1 2 abnormal erythropoiesis 0.0397461003309315 0.842726407892208 1.64560015563193 0.114285714285714 1.2 1 2 domed cranium 0.0832041084545608 0.940773726276 1.64560015563193 0.114285714285714 1.2 1 2 abnormal action potential 0.0832041084545608 0.940773726276 1.64560015563193 0.114285714285714 1.2 1 2 embryonic lethality between somite formation and embryo turning, complete penetrance 0.0832041084545608 0.940773726276 1.64560015563193 0.114285714285714 1.2 1 2 hunched posture 0.0699251045364143 0.842726407892208 1.64039256020272 0.113924050632911 1.2 1 2 abnormal nervous system morphology 0.0699251045364143 0.842726407892208 1.64039256020272 0.113924050632911 1.2 1 2 decreased anxiety-related response 0.0287708935580797 0.786457117865089 1.63891072410497 0.113821138211382 1.2 1 2 renal interstitial fibrosis 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 abnormal photoreceptor outer segment morphology 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 decreased macrophage cell number 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 cochlear hair cell degeneration 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 embryonic growth arrest 0.00403547326479693 0.404394182866274 1.6348211153112 0.11353711790393 1.2 1 2 decreased body length 0.00191741274524395 0.330120617348219 1.62908409567577 0.113138686131387 1.2 1 2 abnormal cell cycle 0.0359179306336675 0.842726407892208 1.62771319741854 0.11304347826087 1.2 1 2 corneal opacity 0.0887154598601459 0.96396048807612 1.6224226886512 0.112676056338028 1.2 1 2 abnormal posture 0.0744747751887915 0.875914909135314 1.61988765320018 0.1125 1.2 1 2 prenatal lethality, complete penetrance 0.00240128660659821 0.341554971955991 1.60564403674518 0.111510791366906 1.2 1 2 short snout 0.0476816796085863 0.842726407892208 1.59988904019771 0.111111111111111 1.2 1 2 gliosis 0.113125755403547 0.982978901917165 1.59988904019771 0.111111111111111 1.2 1 2 abnormal maxilla morphology 0.136341043092165 1 1.59988904019771 0.111111111111111 1.2 1 2 trabecula carnea hypoplasia 0.165651716308184 1 1.59988904019771 0.111111111111111 1.2 1 2 abnormal ovarian follicle morphology 0.165651716308184 1 1.59988904019771 0.111111111111111 1.2 1 2 thrombocytopenia 0.0264538139419534 0.743546465317616 1.58885532267911 0.110344827586207 1.2 1 2 increased blood urea nitrogen level 0.0264538139419534 0.743546465317616 1.58885532267911 0.110344827586207 1.2 1 2 abnormal vertebrae morphology 0.0505520671755582 0.842726407892208 1.58521115909498 0.110091743119266 1.2 1 2 increased thermal nociceptive threshold 0.070765708639015 0.842726407892208 1.58230784195378 0.10989010989011 1.2 1 2 abnormal excitatory postsynaptic potential 0.0841077470681618 0.94883456159661 1.58037819824408 0.109756097560976 1.2 1 2 abnormal learning/memory/conditioning 0.145175507165892 1 1.57080014855775 0.109090909090909 1.2 1 2 small testis 0.00406426314438466 0.404394182866274 1.56510884367167 0.108695652173913 1.2 1 2 embryonic lethality between implantation and placentation, complete penetrance 0.176621375586415 1 1.56510884367167 0.108695652173913 1.2 1 2 abnormal neural tube closure 0.0891911572755577 0.96396048807612 1.56133749706042 0.108433734939759 1.2 1 2 abnormal heart morphology 0.00862101702392245 0.525549748030445 1.55833348071206 0.108225108225108 1.2 1 2 small seminiferous tubules 0.106482177512276 0.982978901917165 1.55664879586804 0.108108108108108 1.2 1 2 increased anxiety-related response 0.0366628830187324 0.842726407892208 1.55384906781792 0.107913669064748 1.2 1 2 kinked tail 0.0669693069804509 0.842726407892208 1.5528334801919 0.107843137254902 1.2 1 2 abnormal eye development 0.154263040330656 1 1.54275014590493 0.107142857142857 1.2 1 2 delayed bone ossification 0.112809666174481 0.982978901917165 1.5358934785898 0.106666666666667 1.2 1 2 abnormal limb morphology 0.112809666174481 0.982978901917165 1.5358934785898 0.106666666666667 1.2 1 2 decreased hemoglobin content 0.0408084133104679 0.842726407892208 1.53180865550845 0.106382978723404 1.2 1 2 hepatic necrosis 0.187856272424214 1 1.53180865550845 0.106382978723404 1.2 1 2 abnormal tail morphology 0.13541300192395 1 1.52716681109781 0.106060606060606 1.2 1 2 abnormal cardiovascular system physiology 0.0505503814731253 0.842726407892208 1.51568435387152 0.105263157894737 1.2 1 2 abnormal circulating amino acid level 0.163594209969779 1 1.51568435387152 0.105263157894737 1.2 1 2 impaired glucose tolerance 0.0111056649677553 0.595962830367755 1.50957272341236 0.104838709677419 1.2 1 2 abnormal glucose homeostasis 0.0279683816237745 0.768854994110583 1.50319244985609 0.104395604395604 1.2 1 2 embryonic lethality during organogenesis, incomplete penetrance 0.0150275672443782 0.678106404582466 1.50250448992481 0.104347826086957 1.2 1 2 increased susceptibility to pharmacologically induced seizures 0.0935197153799831 0.968436157929962 1.49989597518535 0.104166666666667 1.2 1 2 abnormal cardiovascular system morphology 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 small heart 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 vertebral transformation 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 abnormal phalanx morphology 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 enlarged heart 0.016541929747067 0.678106404582466 1.48955186501166 0.103448275862069 1.2 1 2 perinatal lethality, complete penetrance 0.0213819822566375 0.692214877656388 1.48722079793027 0.103286384976526 1.2 1 2 abnormal myocardial fiber morphology 0.0985366578127471 0.982978901917165 1.48443313008035 0.103092783505155 1.2 1 2 decreased mean corpuscular hemoglobin 0.1513761542269 1 1.48225014018317 0.102941176470588 1.2 1 2 double outlet right ventricle 0.0874530178020925 0.96396048807612 1.4802711680334 0.102803738317757 1.2 1 2 increased body weight 0.0201815518447175 0.692214877656388 1.47846888982556 0.102678571428571 1.2 1 2 abnormal suckling behavior 0.117251890170661 0.982978901917165 1.47262513927289 0.102272727272727 1.2 1 2 hyperglycemia 0.117251890170661 0.982978901917165 1.47262513927289 0.102272727272727 1.2 1 2 short femur 0.117251890170661 0.982978901917165 1.47262513927289 0.102272727272727 1.2 1 2 organ of Corti degeneration 0.211053904630434 1 1.4692858532428 0.102040816326531 1.2 1 2 decreased urine osmolality 0.211053904630434 1 1.4692858532428 0.102040816326531 1.2 1 2 decreased bone mineral density 0.0145716395222725 0.678106404582466 1.46155276980468 0.101503759398496 1.2 1 2 abnormal coat appearance 0.159671850456479 1 1.46076825409356 0.101449275362319 1.2 1 2 abnormal placenta morphology 0.140077087784572 1 1.45812672018019 0.10126582278481 1.2 1 2 abnormal visceral yolk sac morphology 0.140077087784572 1 1.45812672018019 0.10126582278481 1.2 1 2 increased heart weight 0.0680397036845497 0.842726407892208 1.45025912996339 0.100719424460432 1.2 1 2 decreased insulin secretion 0.129683915398177 1 1.43990013617794 0.1 1.2 1 2 impaired fertilization 0.16816826623447 1 1.43990013617794 0.1 1.2 1 2 abnormal axon extension 0.222981901301094 1 1.43990013617794 0.1 1.2 1 2 respiratory failure 0.0665886650337562 0.842726407892208 1.43036437368669 0.0993377483443709 1.2 1 2 cataract 0.0943176075000878 0.968436157929962 1.4280001350525 0.0991735537190083 1.2 1 2 abnormal bone mineralization 0.0943176075000878 0.968436157929962 1.4280001350525 0.0991735537190083 1.2 1 2 increased grip strength 0.136150547847354 1 1.4240770577584 0.0989010989010989 1.2 1 2 abnormal neural tube morphology 0.0621907514598502 0.842726407892208 1.42212359128685 0.0987654320987654 1.2 1 2 neonatal lethality, complete penetrance 0.00355969404694281 0.393543952967567 1.42095408175455 0.0986842105263158 1.2 1 2 increased circulating free fatty acid level 0.176858416931662 1 1.4196198525698 0.0985915492957746 1.2 1 2 abnormal skeletal muscle fiber morphology 0.176858416931662 1 1.4196198525698 0.0985915492957746 1.2 1 2 abnormal spatial learning 0.0649958790268644 0.842726407892208 1.41339890667773 0.098159509202454 1.2 1 2 impaired balance 0.125920621436886 0.983445983749621 1.41166680017445 0.0980392156862745 1.2 1 2 increased lung adenocarcinoma incidence 0.235105834449124 1 1.41166680017445 0.0980392156862745 1.2 1 2 cochlear inner hair cell degeneration 0.235105834449124 1 1.41166680017445 0.0980392156862745 1.2 1 2 increased bone mineral density 0.116576387626893 0.982978901917165 1.40167269893428 0.0973451327433628 1.2 1 2 abnormal cranium morphology 0.0959351237444617 0.980035401701637 1.39691804256069 0.0970149253731343 1.2 1 2 decreased body weight 7.42135229450567e-06 0.0369212276651657 1.39570287836311 0.0969305331179321 1.2 1 2 increased tumor incidence 0.108026932837802 0.982978901917165 1.39345174468833 0.0967741935483871 1.2 1 2 pericardial effusion 0.213541878295052 1 1.39345174468833 0.0967741935483871 1.2 1 2 abnormal cell morphology 0.121907128138127 0.982978901917165 1.38937732438222 0.0964912280701754 1.2 1 2 postnatal lethality 0.0739189671996203 0.871438061180357 1.38785555294259 0.0963855421686747 1.2 1 2 abnormal lipid level 0.170300336775494 1 1.38785555294259 0.0963855421686747 1.2 1 2 absent corpus luteum 0.247407921974841 1 1.38451936170956 0.0961538461538462 1.2 1 2 kinked neural tube 0.247407921974841 1 1.38451936170956 0.0961538461538462 1.2 1 2 cleft secondary palate 0.156519361224479 1 1.3786277899576 0.0957446808510638 1.2 1 2 abnormal skeleton morphology 0.127371601068644 0.988570538715292 1.37729578243107 0.0956521739130435 1.2 1 2 arrest of spermatogenesis 0.178284364541424 1 1.37133346302661 0.0952380952380952 1.2 1 2 decreased exploration in new environment 0.178284364541424 1 1.37133346302661 0.0952380952380952 1.2 1 2 abnormal humoral immune response 0.144141194956983 1 1.37133346302661 0.0952380952380952 1.2 1 2 postnatal lethality, incomplete penetrance 0.0033670224060849 0.385038089286213 1.36891914354945 0.0950704225352113 1.2 1 2 decreased leukocyte cell number 0.109041146054038 0.982978901917165 1.36632859637323 0.0948905109489051 1.2 1 2 impaired righting response 0.163621138719926 1 1.36411591848436 0.0947368421052632 1.2 1 2 abnormal intestine morphology 0.204016554204282 1 1.36206769638454 0.0945945945945946 1.2 1 2 abnormal mesoderm development 0.259870359395535 1 1.35839635488485 0.0943396226415094 1.2 1 2 abnormal pancreatic islet morphology 0.259870359395535 1 1.35839635488485 0.0943396226415094 1.2 1 2 cyanosis 0.0751662431061253 0.88196240437022 1.34990637766682 0.09375 1.2 1 2 decreased circulating LDL cholesterol level 0.234848389408475 1 1.34990637766682 0.09375 1.2 1 2 decreased body size 0.00135087906028527 0.280025971871635 1.33524574031538 0.0927318295739348 1.2 1 2 abnormal chondrocyte morphology 0.272475391671388 1 1.33324086683143 0.0925925925925926 1.2 1 2 increased cell proliferation 0.272475391671388 1 1.33324086683143 0.0925925925925926 1.2 1 2 abnormal trabecular bone morphology 0.150537557791893 1 1.33100012587877 0.092436974789916 1.2 1 2 decreased monocyte cell number 0.245738980859888 1 1.32913858724117 0.0923076923076923 1.2 1 2 decreased embryo size 0.0128452423343891 0.626520398172412 1.32543108769517 0.0920502092050209 1.2 1 2 abnormal spleen morphology 0.101525691128317 0.982978901917165 1.32404610223259 0.0919540229885057 1.2 1 2 short limbs 0.203178799114266 1 1.32404610223259 0.0919540229885057 1.2 1 2 increased bone mineral content 0.170408428216232 1 1.32100929924582 0.0917431192660551 1.2 1 2 postnatal growth retardation 0.00630566304934171 0.475313237431439 1.31755568016282 0.0915032679738562 1.2 1 2 weight loss 0.105371503654159 0.982978901917165 1.31648012450554 0.0914285714285714 1.2 1 2 increased circulating calcium level 0.285205380121938 1 1.30900012379813 0.0909090909090909 1.2 1 2 abnormal skin morphology 0.256771578753482 1 1.30900012379813 0.0909090909090909 1.2 1 2 abnormal CNS synaptic transmission 0.193488872670772 1 1.30900012379813 0.0909090909090909 1.2 1 2 increased T cell number 0.211771490008626 1 1.30900012379813 0.0909090909090909 1.2 1 2 decreased circulating total protein level 0.285205380121938 1 1.30900012379813 0.0909090909090909 1.2 1 2 increased insulin sensitivity 0.138254397381627 1 1.30900012379813 0.0909090909090909 1.2 1 2 abnormal gait 0.0474737533035372 0.842726407892208 1.30476387744279 0.0906148867313916 1.2 1 2 abnormal hepatocyte morphology 0.184338150350508 1 1.29720732989004 0.0900900900900901 1.2 1 2 increased circulating alanine transaminase level 0.242463948581151 1 1.29221807092892 0.0897435897435897 1.2 1 2 abnormal seminal vesicle morphology 0.298042864415201 1 1.28562512158745 0.0892857142857143 1.2 1 2 abnormal pulmonary alveolus morphology 0.20923925893946 1 1.28307932926747 0.0891089108910891 1.2 1 2 abnormal seminiferous tubule morphology 0.154319344027032 1 1.28210286098036 0.089041095890411 1.2 1 2 decreased B cell proliferation 0.252418226714152 1 1.27586088015767 0.0886075949367089 1.2 1 2 abnormal myocardium layer morphology 0.252418226714152 1 1.27586088015767 0.0886075949367089 1.2 1 2 abnormal embryo size 0.1987641064711 1 1.27424790812207 0.0884955752212389 1.2 1 2 abnormal extraembryonic tissue morphology 0.217302352891322 1 1.27050012015701 0.0882352941176471 1.2 1 2 decreased circulating alanine transaminase level 0.279213701586311 1 1.270500120157 0.0882352941176471 1.2 1 2 preweaning lethality, incomplete penetrance 0.0400570017906574 0.842726407892208 1.26739376289501 0.0880195599022005 1.2 1 2 embryonic lethality before implantation, complete penetrance 0.188996284369429 1 1.26711211983659 0.088 1.2 1 2 abnormal craniofacial bone morphology 0.310970619650338 1 1.26307029489293 0.087719298245614 1.2 1 2 increased hepatocellular carcinoma incidence 0.310970619650338 1 1.26307029489293 0.087719298245614 1.2 1 2 abnormal retinal pigment epithelium morphology 0.262491705503182 1 1.2599126191557 0.0875 1.2 1 2 male infertility 0.0279724128510584 0.768854994110583 1.25955479109005 0.0874751491053678 1.2 1 2 abnormal craniofacial morphology 0.225484108132455 1 1.25816516753412 0.087378640776699 1.2 1 2 premature death 0.00608695164511781 0.465885914376325 1.25426841130483 0.0871080139372822 1.2 1 2 decreased T cell number 0.163284103392557 1 1.25208707493734 0.0869565217391304 1.2 1 2 improved glucose tolerance 0.137486768239041 1 1.24889297525638 0.086734693877551 1.2 1 2 cachexia 0.233779399728043 1 1.2460674255386 0.0865384615384615 1.2 1 2 decreased bone mineral content 0.131409091454855 1 1.2460674255386 0.0865384615384615 1.2 1 2 increased circulating alkaline phosphatase level 0.16875249832177 1 1.244358142376 0.0864197530864197 1.2 1 2 abnormal eye morphology 0.192583613989939 1 1.24307925425434 0.0863309352517986 1.2 1 2 decreased circulating glucose level 0.0980589366441262 0.982978901917165 1.23862377305629 0.0860215053763441 1.2 1 2 hypoglycemia 0.256658795188041 1 1.23862377305629 0.0860215053763441 1.2 1 2 abnormal definitive hematopoiesis 0.256658795188041 1 1.23862377305629 0.0860215053763441 1.2 1 2 embryonic lethality during organogenesis, complete penetrance 0.0308474336969197 0.808201246875771 1.23420011672395 0.0857142857142857 1.2 1 2 pallor 0.166048402119099 1 1.23420011672395 0.0857142857142857 1.2 1 2 anemia 0.144123172406925 1 1.22835082707123 0.0853080568720379 1.2 1 2 neonatal lethality, incomplete penetrance 0.12371650926323 0.982978901917165 1.21837703830441 0.0846153846153846 1.2 1 2 abnormal ovary morphology 0.313635078421741 1 1.2168170164884 0.0845070422535211 1.2 1 2 alopecia 0.275385857131689 1 1.21254748309721 0.0842105263157895 1.2 1 2 lethality throughout fetal growth and development, complete penetrance 0.173406354666932 1 1.21254748309721 0.0842105263157895 1.2 1 2 decreased total body fat amount 0.100462942613832 0.982978901917165 1.20710191056833 0.0838323353293413 1.2 1 2 abnormal eating behavior 0.350127857054334 1 1.19991678014828 0.0833333333333333 1.2 1 2 intracranial hemorrhage 0.350127857054334 1 1.19991678014828 0.0833333333333333 1.2 1 2 abnormal long bone epiphyseal plate morphology 0.350127857054334 1 1.19991678014828 0.0833333333333333 1.2 1 2 abnormal forebrain development 0.325262360000466 1 1.19991678014828 0.0833333333333333 1.2 1 2 abnormal heart left ventricle morphology 0.325262360000466 1 1.19991678014828 0.0833333333333333 1.2 1 2 postnatal lethality, complete penetrance 0.0938952009189701 0.968436157929962 1.19369959475891 0.0829015544041451 1.2 1 2 decreased erythrocyte cell number 0.220813785334207 1 1.19227399810912 0.0828025477707006 1.2 1 2 increased circulating triglyceride level 0.233038107802027 1 1.19164149200933 0.0827586206896552 1.2 1 2 decreased B cell number 0.185195312627094 1 1.18826710267111 0.0825242718446602 1.2 1 2 abnormal lung development 0.314328716053502 1 1.18580011214654 0.0823529411764706 1.2 1 2 circling 0.314328716053502 1 1.18580011214654 0.0823529411764706 1.2 1 2 hypoactivity 0.105621669673411 0.982978901917165 1.18400276449645 0.0822281167108753 1.2 1 2 decreased hematocrit 0.240087549334117 1 1.18347956398187 0.0821917808219178 1.2 1 2 seminiferous tubule degeneration 0.336946422443904 1 1.18347956398187 0.0821917808219178 1.2 1 2 increased total body fat amount 0.253894354214474 1 1.18200757447443 0.082089552238806 1.2 1 2 increased double-negative T cell number 0.363250884430489 1 1.18024601326061 0.0819672131147541 1.2 1 2 decreased litter size 0.150733407821435 1 1.1785659477613 0.0818505338078292 1.2 1 2 embryonic lethality between implantation and somite formation, complete penetrance 0.173518936682576 1 1.17542868259424 0.0816326530612245 1.2 1 2 abnormal embryonic tissue morphology 0.24721687164393 1 1.17542868259424 0.0816326530612245 1.2 1 2 increased sensitivity to induced morbidity/mortality 0.216550075624839 1 1.17383163275375 0.0815217391304348 1.2 1 2 abnormal rib morphology 0.261552585504066 1 1.17325196281165 0.0814814814814815 1.2 1 2 decreased IgG level 0.294572640084122 1 1.16748659690103 0.0810810810810811 1.2 1 2 abnormal angiogenesis 0.348675528465047 1 1.16748659690103 0.0810810810810811 1.2 1 2 decreased cell proliferation 0.222543810603184 1 1.16748659690103 0.0810810810810811 1.2 1 2 deafness 0.313855707693923 1 1.16355566559833 0.0808080808080808 1.2 1 2 prenatal lethality 0.376383253389738 1 1.16120978724027 0.0806451612903226 1.2 1 2 increased eosinophil cell number 0.376383253389738 1 1.16120978724027 0.0806451612903226 1.2 1 2 abnormal retinal pigmentation 0.335579018509746 1 1.15854033945351 0.0804597701149425 1.2 1 2 abnormal coat/hair pigmentation 0.303579786177465 1 1.1570626094287 0.0803571428571429 1.2 1 2 decreased heart rate 0.323643176421793 1 1.15192010894235 0.08 1.2 1 2 increased or absent threshold for auditory brainstem response 0.183346655644426 1 1.14594128484749 0.0795847750865052 1.2 1 2 increased liver weight 0.346278434553052 1 1.14537510832336 0.0795454545454545 1.2 1 2 abnormal hair follicle morphology 0.389510085880736 1 1.14277788585551 0.0793650793650794 1.2 1 2 increased circulating aspartate transaminase level 0.389510085880736 1 1.14277788585551 0.0793650793650794 1.2 1 2 reduced male fertility 0.222656672518951 1 1.14177103309264 0.079295154185022 1.2 1 2 abnormal behavior 0.196738276367274 1 1.13948931639981 0.079136690647482 1.2 1 2 no abnormal phenotype detected 0.00995538747819591 0.569287962115226 1.13698166372552 0.0789625360230548 1.2 1 2 abnormal blood homeostasis 0.321778617270315 1 1.13676326540364 0.0789473684210526 1.2 1 2 anophthalmia 0.357015518622012 1 1.13250572508377 0.0786516853932584 1.2 1 2 increased startle reflex 0.357015518622012 1 1.13250572508377 0.0786516853932584 1.2 1 2 abnormal muscle physiology 0.357015518622012 1 1.13250572508377 0.0786516853932584 1.2 1 2 microphthalmia 0.291492389535349 1 1.12933344013956 0.0784313725490196 1.2 1 2 abnormal testis morphology 0.330958728667987 1 1.1268783674436 0.0782608695652174 1.2 1 2 lethality throughout fetal growth and development, incomplete penetrance 0.274277270231937 1 1.12617887745761 0.0782122905027933 1.2 1 2 abnormal lens morphology 0.319544663492089 1 1.12492198138901 0.078125 1.2 1 2 abnormal osteoclast physiology 0.402617009310589 1 1.12492198138901 0.078125 1.2 1 2 polyuria 0.384018865155308 1 1.12200010611268 0.0779220779220779 1.2 1 2 abnormal cytokine secretion 0.299090823719815 1 1.12200010611268 0.0779220779220779 1.2 1 2 abnormal bone structure 0.27285572484966 1 1.11909337008648 0.077720207253886 1.2 1 2 abnormal lipid homeostasis 0.336845282923721 1 1.10761548936765 0.0769230769230769 1.2 1 2 increased embryonic tissue cell apoptosis 0.395815108203154 1 1.10761548936765 0.0769230769230769 1.2 1 2 abnormal B cell differentiation 0.378567860833289 1 1.10761548936765 0.0769230769230769 1.2 1 2 spleen hypoplasia 0.373245346564252 1 1.09706677042129 0.0761904761904762 1.2 1 2 increased circulating HDL cholesterol level 0.373245346564252 1 1.09706677042129 0.0761904761904762 1.2 1 2 abnormal spermatogenesis 0.308934094889055 1 1.09557619057017 0.0760869565217391 1.2 1 2 abnormal response to infection 0.407601153257045 1 1.09359504013514 0.0759493670886076 1.2 1 2 impaired swimming 0.428716293069021 1 1.09083343649844 0.0757575757575758 1.2 1 2 abnormal lung morphology 0.368082613174484 1 1.08900010299172 0.0756302521008403 1.2 1 2 edema 0.326542981686216 1 1.08829661455309 0.0755813953488372 1.2 1 2 extramedullary hematopoiesis 0.38324990561276 1 1.08671708390788 0.0754716981132075 1.2 1 2 lethargy 0.400167804821678 1 1.08379580142426 0.0752688172043011 1.2 1 2 increased circulating insulin level 0.345684968552973 1 1.07992510213345 0.075 1.2 1 2 rib fusion 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 internal hemorrhage 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 decreased white adipose tissue amount 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 abnormal skeleton development 0.431102100582259 1 1.06659269346514 0.0740740740740741 1.2 1 2 abnormal embryo development 0.389564468823215 1 1.05875010013084 0.0735294117647059 1.2 1 2 abnormal inhibitory postsynaptic currents 0.454576971738899 1 1.05875010013084 0.0735294117647059 1.2 1 2 sparse hair 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 abnormal developmental patterning 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 abnormal response/metabolism to endogenous compounds 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 retinal degeneration 0.432514185139269 1 1.04992718262975 0.0729166666666667 1.2 1 2 abnormal epidermal layer morphology 0.467387778922474 1 1.04340589578112 0.072463768115942 1.2 1 2 thymus hypoplasia 0.407283891146431 1 1.04340589578112 0.072463768115942 1.2 1 2 hemorrhage 0.358334365027861 1 1.04162988574574 0.0723404255319149 1.2 1 2 preweaning lethality, complete penetrance 0.247621002228089 1 1.03127982726258 0.0716216216216216 1.2 1 2 female infertility 0.367507834908016 1 1.02850009726996 0.0714285714285714 1.2 1 2 decreased circulating cholesterol level 0.410202991765355 1 1.02287987815919 0.0710382513661202 1.2 1 2 abnormal motor coordination/ balance 0.464612141992738 1 1.01811120739854 0.0707070707070707 1.2 1 2 decreased circulating serum albumin level 0.464612141992738 1 1.01811120739854 0.0707070707070707 1.2 1 2 cardiac fibrosis 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 decreased lymphocyte cell number 0.452444228799826 1 1.01242978325011 0.0703125 1.2 1 2 seizures 0.463181608776146 1 1.01045623591434 0.0701754385964912 1.2 1 2 abnormal enzyme/coenzyme activity 0.4422258258674 1 1.00884722916926 0.0700636942675159 1.2 1 2 cochlear outer hair cell degeneration 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 azoospermia 0.459009084383764 1 0.996157326915555 0.0691823899371069 1.2 1 2 increased leukocyte cell number 0.469164864131151 1 0.993034576674441 0.0689655172413793 1.2 1 2 decreased percent body fat/body weight 0.517584260442865 1 0.98623296998489 0.0684931506849315 1.2 1 2 decreased neutrophil cell number 0.492705744876713 1 0.984547101660129 0.0683760683760684 1.2 1 2 abnormal motor capabilities/coordination/movement 0.489534146184827 1 0.981750092848595 0.0681818181818182 1.2 1 2 small kidney 0.511640280960568 1 0.981750092848595 0.0681818181818182 1.2 1 2 abnormal retina morphology 0.499174503406732 1 0.959933424118626 0.0666666666666667 1.2 1 2 abnormal eye electrophysiology 0.531306605729757 1 0.952000090035001 0.0661157024793388 1.2 1 2 enlarged spleen 0.505654685084823 1 0.949934117617391 0.0659722222222222 1.2 1 2 small ovary 0.544856063713358 1 0.949384705172267 0.0659340659340659 1.2 1 2 obese 0.56566920111548 1 0.935000088427233 0.0649350649350649 1.2 1 2 abnormal axon morphology 0.55760351006193 1 0.933268606781998 0.0648148148148148 1.2 1 2 increased rib number 0.577303043095776 1 0.923012907806371 0.0641025641025641 1.2 1 2 small liver 0.577303043095776 1 0.923012907806371 0.0641025641025641 1.2 1 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.577304813882492 1 0.916300086658689 0.0636363636363636 1.2 1 2 abnormal somite development 0.588769387003798 1 0.91132920011262 0.0632911392405063 1.2 1 2 increased inflammatory response 0.587499185030258 1 0.909410612322909 0.0631578947368421 1.2 1 2 abnormal social investigation 0.600062893860318 1 0.899937585111212 0.0625 1.2 1 2 increased circulating cholesterol level 0.596171430124076 1 0.899937585111212 0.0625 1.2 1 2 abnormal neuron differentiation 0.596575303461178 1 0.899937585111212 0.0625 1.2 1 2 increased spleen weight 0.606039614606741 1 0.891973535685449 0.0619469026548673 1.2 1 2 cardiac hypertrophy 0.6180717578282 1 0.881571511945677 0.0612244897959184 1.2 1 2 insulin resistance 0.630822999927037 1 0.872666749198751 0.0606060606060606 1.2 1 2 increased mean corpuscular hemoglobin 0.627972378204682 1 0.872666749198751 0.0606060606060606 1.2 1 2 enlarged liver 0.637722357071335 1 0.863940081706763 0.06 1.2 1 2 hydronephrosis 0.643419337009177 1 0.85708341439163 0.0595238095238095 1.2 1 2 abnormal T cell differentiation 0.647318862250332 1 0.855386219511647 0.0594059405940594 1.2 1 2 lung inflammation 0.66397558374287 1 0.84700008010467 0.0588235294117647 1.2 1 2 decreased cardiac muscle contractility 0.675163796034013 1 0.830711617025734 0.0576923076923077 1.2 1 2 teratozoospermia 0.683709636184508 1 0.818125077373829 0.0568181818181818 1.2 1 2 increased circulating glucose level 0.702811801287601 1 0.816964616271171 0.0567375886524823 1.2 1 2 infertility 0.701554131669677 1 0.807420637109125 0.0560747663551402 1.2 1 2 increased T cell proliferation 0.701554131669677 1 0.807420637109125 0.0560747663551402 1.2 1 2 abnormal liver morphology 0.732325939263332 1 0.80441348389829 0.0558659217877095 1.2 1 2 thin ventricular wall 0.702662668708324 1 0.799944520098855 0.0555555555555556 1.2 1 2 abnormal renal glomerulus morphology 0.718323706728615 1 0.792605579547489 0.055045871559633 1.2 1 2 small spleen 0.711837471324311 1 0.79115392097689 0.0549450549450549 1.2 1 2 decreased birth weight 0.746522162322107 1 0.757842176935758 0.0526315789473684 1.2 1 2 increased B cell number 0.778766944177614 1 0.738410326245097 0.0512820512820513 1.2 1 2 increased monocyte cell number 0.785398513201621 1 0.71995006808897 0.05 1.2 1 2 decreased T cell proliferation 0.852727845903826 1 0.681033848192269 0.0472972972972973 1.2 1 2 decreased circulating HDL cholesterol level 0.845158084945041 1 0.674953188833409 0.046875 1.2 1 2 abnormal dendritic cell physiology 0.83183241061067 1 0.672850530924271 0.0467289719626168 1.2 1 2 liver inflammation 0.896206026087112 1 0.599958390074141 0.0416666666666667 1.2 1 2 increased neutrophil cell number 0.915082062422259 1 0.595820746004665 0.0413793103448276 1.2 1 2 abnormal immune system physiology 0.911152539473525 1 0.580604893620137 0.0403225806451613 1.2 1 2 absent popliteal lymph nodes 0.000224127456034543 0.00325082826172552 2.32099853157122 1 1.1 1 1 gastric polyps 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 sirenomelia 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 thyroid hypoplasia 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 abnormal response to vitamins 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 abnormal inner cell mass proliferation 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 corneal deposits 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 abnormal olfactory bulb granule cell layer morphology 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 absent cervical lymph nodes 0.000444694907678638 0.0054357669918949 2.06310980584108 0.888888888888889 1.1 1 1 abnormal cerebellar layer morphology 0.000444694907678638 0.0054357669918949 2.06310980584108 0.888888888888889 1.1 1 1 liver cysts 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 elevated level of mitotic sister chromatid exchange 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 binucleate 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal kidney epithelium morphology 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal thymus epithelium morphology 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal olfactory bulb glomerular layer morphology 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal heart echocardiography feature 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 increased cornea thickness 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal kidney blood vessel morphology 2.62808812374185e-05 0.000554014339644732 1.98942731277533 0.857142857142857 1.1 1 1 mammary gland hyperplasia 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal lacrimal gland morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal gastrulation movements 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal lymph node primary follicle morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal nephron morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal optic tract morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 heart hemorrhage 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal T wave 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 decreased collagen level 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 thin tail 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 non-obstructive hydrocephaly 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal lymph node cortex morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal cervical lymph node morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 chromatolysis 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased liver function 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal zona pellucida morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal milk ejection 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased prostate gland weight 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased platelet ADP level 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 absent sperm mitochondrial sheath 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 increased erythrocyte clearance 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 enlarged lymphatic vessel 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 myocardium hypoplasia 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 persistent hyperplastic primary vitreous 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal kidney collecting duct epithelium morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 absent midbrain 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 increased bone trabecular spacing 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 ectopic bone 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 increased cardiac cell glucose uptake 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased atrioventricular cushion size 0.000594464145534409 0.0068778119163574 1.89899879855827 0.818181818181818 1.1 1 1 abnormal coronary vessel morphology 9.50792441424714e-05 0.00158911425252399 1.85679882525697 0.8 1.1 1 1 retarded hair growth 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 abnormal mammary gland physiology 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 absent inguinal lymph nodes 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 absent axillary lymph nodes 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 intestinal obstruction 0.000254912053925613 0.00357827963891112 1.82364170337739 0.785714285714286 1.1 1 1 abnormal embryonic hematopoiesis 2.82889978929991e-08 1.36638606327836e-06 1.81328010279001 0.78125 1.1 1 1 heart hyperplasia 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 abnormal geniculate ganglion morphology 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 abnormal kindling response 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 liver hyperplasia 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 eye opacity 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 prolonged RR interval 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 abnormal heart left ventricle pressure 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 increased cardiac muscle glycogen level 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 coloboma 0.000107320614091988 0.00173915327396625 1.77488123002505 0.764705882352941 1.1 1 1 abnormal neuron proliferation 4.48316812782396e-05 0.000851288604424587 1.74074889867841 0.75 1.1 1 1 decreased creatinine clearance 0.000275444411689493 0.00368608986724681 1.74074889867841 0.75 1.1 1 1 kidney degeneration 0.000275444411689493 0.00368608986724681 1.74074889867841 0.75 1.1 1 1 abnormal thymus involution 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 dilated bile duct 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 small intestinal inflammation 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 absent ovary 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 pale placenta 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 abnormal somatic nervous system physiology 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 persistent right dorsal aorta 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 abnormal pulmonary valve cusp morphology 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 spinning 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal erythrocyte cell number 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 decreased aerobic running capacity 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 hypospadia 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal umbilical artery morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 colon polyps 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 pulmonary interstitial fibrosis 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal eyelid aperture 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal skin development 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 tau protein deposits 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal NK cell morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal somite size 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal olfactory bulb mitral cell layer morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal anterior commissure pars posterior morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal bronchiole epithelium morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 increased airway resistance 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal foramen magnum morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 small thymus medulla 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 increased mammary gland apoptosis 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 absent incisors 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 placental labyrinth hypoplasia 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 abnormal glial cell morphology 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 abnormal branching involved in lung morphogenesis 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 increased bone volume 4.62774821769597e-05 0.000868794240869337 1.6879989320518 0.727272727272727 1.1 1 1 abnormal proximal-distal axis patterning 0.00439645901930679 0.0328908024376711 1.6879989320518 0.727272727272727 1.1 1 1 cyclopia 0.00439645901930679 0.0328908024376711 1.6879989320518 0.727272727272727 1.1 1 1 abnormal mitral valve morphology 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 increased circulating renin level 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 long tibia 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 amyloid beta deposits 0.00171545189658141 0.0163523590701601 1.65785609397944 0.714285714285714 1.1 1 1 abnormal maternal decidual layer morphology 0.00171545189658141 0.0163523590701601 1.65785609397944 0.714285714285714 1.1 1 1 multiple persisting craniopharyngeal ducts 0.00171545189658141 0.0163523590701601 1.65785609397944 0.714285714285714 1.1 1 1 failure of atrioventricular cushion closure 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 excessive tearing 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 limp posture 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal circulating free fatty acids level 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal tumor incidence 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal brain ventricular system morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 absent tunnel of Corti 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 renal necrosis 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal cochlear nerve compound action potential 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal MHC II cell surface expression on macrophages 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal gallbladder morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 atherosclerotic lesions 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal renal/urinary system physiology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 uremia 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal prostaglandin level 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal sperm annulus morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 decreased T-helper 17 cell number 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 heart block 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal conotruncal ridge morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal aortic valve cusp morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 thick pulmonary valve 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 increased right ventricle systolic pressure 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 decreased CD8-positive, naive alpha-beta T cell number 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 dysmyelination 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 decreased hair follicle number 2.32244296918642e-07 8.75314679674426e-06 1.64913053559008 0.710526315789474 1.1 1 1 hemolytic anemia 4.59598229881838e-05 0.000866098936993236 1.64404062652961 0.708333333333333 1.1 1 1 abnormal testis development 0.000678941525923503 0.00759041368869534 1.63835190463851 0.705882352941177 1.1 1 1 abnormal cell proliferation 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 abnormal circulating enzyme level 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 anencephaly 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 abnormal Peyer's patch T cell area morphology 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 spleen atrophy 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 abnormal physiological neovascularization 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 absent ductus venosus valve 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 fused cornea and lens 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 impaired basement membrane formation 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal tibialis anterior morphology 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 peritoneal inflammation 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 bifid ureter 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 absent CD4-positive, alpha beta T cells 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal gas homeostasis 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal respiratory conducting tube morphology 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal cerebellar granule cell migration 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal retinal blood vessel pattern 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 acanthocytosis 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 thick aortic valve 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased macrophage cytokine production 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased macrophage apoptosis 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased circulating lactate level 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased circulating creatinine level 1.64480434589986e-08 8.70521449026789e-07 1.6104887770086 0.693877551020408 1.1 1 1 abnormal nasal bone morphology 4.43462283155721e-05 0.000848548022576813 1.60684513724161 0.692307692307692 1.1 1 1 abnormal bile duct development 0.00413854314333792 0.0315786075737825 1.60684513724161 0.692307692307692 1.1 1 1 increased mortality induced by gamma-irradiation 1.80643498313863e-05 0.000401205983978335 1.60068864246291 0.689655172413793 1.1 1 1 poor circulation 0.00161626959293673 0.0158598446249709 1.59568649045521 0.6875 1.1 1 1 abnormal epicardium morphology 0.00161626959293673 0.0158598446249709 1.59568649045521 0.6875 1.1 1 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00161626959293673 0.0158598446249709 1.59568649045521 0.6875 1.1 1 1 abnormal triglyceride level 0.000640083317798156 0.00730370299551795 1.58805162686452 0.684210526315789 1.1 1 1 oliguria 0.000640083317798156 0.00730370299551795 1.58805162686452 0.684210526315789 1.1 1 1 decreased circulating magnesium level 0.000640083317798156 0.00730370299551795 1.58805162686452 0.684210526315789 1.1 1 1 decreased blood urea nitrogen level 2.12547524076069e-07 8.07193841433925e-06 1.58249899879856 0.681818181818182 1.1 1 1 intestinal inflammation 0.000256053779186404 0.00357827963891112 1.58249899879856 0.681818181818182 1.1 1 1 increased circulating creatine kinase level 0.000256053779186404 0.00357827963891112 1.58249899879856 0.681818181818182 1.1 1 1 abnormal keratinocyte physiology 0.000103211834976652 0.00169593493078694 1.57827900146843 0.68 1.1 1 1 abnormal cochlear outer hair cell morphology 0.000103211834976652 0.00169593493078694 1.57827900146843 0.68 1.1 1 1 abnormal mitotic spindle morphology 4.18513751796433e-05 0.000813322623120022 1.57496328928047 0.678571428571429 1.1 1 1 abnormal object recognition memory 1.70514272147847e-05 0.00038212094771871 1.57228932783857 0.67741935483871 1.1 1 1 abnormal placenta vasculature 3.44566207895126e-08 1.61718573988514e-06 1.56221055009601 0.673076923076923 1.1 1 1 extramedullary hematopoiesis 5.17920786320713e-15 9.54317004424276e-13 1.55463109190148 0.669811320754717 1.1 1 1 vascular ring 0.000588382012941418 0.00682331122233929 1.54733235438081 0.666666666666667 1.1 1 1 enlarged pericardium 1.58433805657309e-05 0.000363229577486227 1.54733235438081 0.666666666666667 1.1 1 1 abnormal brain vasculature morphology 3.88150292917022e-05 0.000766288772723089 1.54733235438081 0.666666666666667 1.1 1 1 abnormal atrioventricular cushion morphology 9.55065651265677e-05 0.00158911425252399 1.54733235438081 0.666666666666667 1.1 1 1 thin epidermis 9.55065651265677e-05 0.00158911425252399 1.54733235438081 0.666666666666667 1.1 1 1 prolonged QT interval 0.000236257225322636 0.00334866010250745 1.54733235438081 0.666666666666667 1.1 1 1 abnormal thyroid cartilage morphology 0.00147816894763903 0.0147077810290084 1.54733235438081 0.666666666666667 1.1 1 1 absent ureter 0.00147816894763903 0.0147077810290084 1.54733235438081 0.666666666666667 1.1 1 1 decreased hepatocyte number 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal pup retrieval 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 delayed intramembranous bone ossification 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal pericyte morphology 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 immune system phenotype 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal cerebral aqueduct morphology 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 ostium primum atrial septal defect 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 heterochrony 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal mineral level 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 abnormal glossopharyngeal nerve morphology 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 interstitial pneumonia 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 increased osteosarcoma incidence 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 decreased left ventricle systolic pressure 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 decreased cochlear nerve compound action potential 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 abnormal cochlear outer hair cell physiology 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 decreased red blood cell distribution width 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 increased skeletal muscle glycogen level 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 distorted hair follicle pattern 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased level of surface class I molecules 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal taste sensitivity 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 biliary cyst 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased cellular sensitivity to ionizing radiation 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased cochlear hair cell number 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal hair cell mechanoelectric transduction 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal gallbladder physiology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased susceptibility to atherosclerosis 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 positive geotaxis 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 multiflagellated sperm 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal telomere morphology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 iris coloboma 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal pulmonary alveolar parenchyma morphology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal ductus venosus valve topology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal coronary sinus connection 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal spongiotrophoblast layer morphology 3.55006044876446e-05 0.000715042539781506 1.52315528634361 0.65625 1.1 1 1 decreased trophoblast giant cell number 8.7046723341332e-05 0.00147298451912628 1.52065421033976 0.655172413793103 1.1 1 1 no spontaneous movement 0.000214402425336471 0.00313721195896748 1.51757596295041 0.653846153846154 1.1 1 1 abnormal hematopoietic stem cell physiology 0.000531044070599033 0.00623100059252403 1.51369469450297 0.652173913043478 1.1 1 1 delayed endochondral bone ossification 2.24214038195786e-06 6.80161487819534e-05 1.51134788102312 0.651162790697674 1.1 1 1 head bobbing 5.43177444848147e-06 0.000147136870951291 1.50864904552129 0.65 1.1 1 1 increased urine calcium level 0.00132463791760038 0.0133402300406112 1.50864904552129 0.65 1.1 1 1 abnormal lung development 4.68767602113224e-11 4.48484388560248e-09 1.50182257925197 0.647058823529412 1.1 1 1 lung hemorrhage 3.21031777630685e-05 0.000657256417165702 1.50182257925197 0.647058823529412 1.1 1 1 abnormal vagus nerve morphology 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal heart rate 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal involuntary movement 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal tarsal bone morphology 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 increased hepatoma incidence 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal electroretinogram waveform feature 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 trabecula carnea hypoplasia 2.02947629237725e-06 6.2712077978738e-05 1.49575460923479 0.644444444444444 1.1 1 1 shortened head 0.000192085907031031 0.00287839574541981 1.4920704845815 0.642857142857143 1.1 1 1 prolonged QRS complex duration 0.000192085907031031 0.00287839574541981 1.4920704845815 0.642857142857143 1.1 1 1 subcutaneous edema 0.000192085907031031 0.00287839574541981 1.4920704845815 0.642857142857143 1.1 1 1 abnormal blood flow velocity 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 increased hemangioma incidence 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 failure of zygotic cell division 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal voluntary movement 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 vascular smooth muscle hypoplasia 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 split sternum 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal viscerocranium morphology 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 decreased cornea thickness 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 decreased tongue size 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal renal tubule epithelial cell primary cilium morphology 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 decreased response to antigen 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 impaired macrophage chemotaxis 1.18617236588469e-05 0.000283711900013285 1.48781957152001 0.641025641025641 1.1 1 1 mandible hypoplasia 0.000472782363715496 0.00564050901555058 1.48543906020558 0.64 1.1 1 1 abnormal egg cylinder morphology 0.000472782363715496 0.00564050901555058 1.48543906020558 0.64 1.1 1 1 heart right ventricle hypertrophy 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 impaired wound healing 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 renal hypoplasia 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 abnormal retinal blood vessel morphology 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 pale yolk sac 2.18586711516824e-10 1.81244814966033e-08 1.48208339967801 0.63855421686747 1.1 1 1 decreased circulating total protein level 2.8360530228363e-07 1.0451380584156e-05 1.47699906554532 0.636363636363636 1.1 1 1 increased skin papilloma incidence 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 increased myocardial infarction size 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 prolonged PR interval 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 abnormal sperm midpiece morphology 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 impaired humoral immune response 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 premature suture closure 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal sphenoid bone morphology 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal thrombopoiesis 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 loss of cortex neurons 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 pulmonary hypertension 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal ureter development 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 pathological neovascularization 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal palate development 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal aorta smooth muscle morphology 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal palatal shelf elevation 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 common atrioventricular valve 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 reduced sympathetic cervical ganglion size 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 liver hypoplasia 6.7948707882711e-07 2.3805973360316e-05 1.47294137580481 0.634615384615385 1.1 1 1 thick ventricular wall 1.05882835149926e-05 0.000262073186502927 1.47185272733785 0.634146341463415 1.1 1 1 abnormal optic cup morphology 0.00017035601306342 0.00260775743074004 1.46996573666177 0.633333333333333 1.1 1 1 abnormal fat pad morphology 0.00017035601306342 0.00260775743074004 1.46996573666177 0.633333333333333 1.1 1 1 abnormal placenta morphology 1.1104128108105e-09 7.8600115756863e-08 1.46898641238685 0.632911392405063 1.1 1 1 abnormal reproductive system physiology 2.55665530201758e-05 0.000541249367129255 1.4658938094134 0.631578947368421 1.1 1 1 kyphoscoliosis 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 thin dermal layer 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 unresponsive to tactile stimuli 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 altered susceptibility to infection 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 decreased germ cell number 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 decreased eye pigmentation 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 decreased liver regeneration 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 abnormal heart valve morphology 0.000416525387693305 0.00515476070590595 1.4613694458041 0.62962962962963 1.1 1 1 abnormal trigeminal nerve morphology 0.000416525387693305 0.00515476070590595 1.4613694458041 0.62962962962963 1.1 1 1 abnormal type II pneumocyte morphology 0.000416525387693305 0.00515476070590595 1.4613694458041 0.62962962962963 1.1 1 1 abnormal liver development 6.18384890241627e-05 0.00111466116991018 1.45891336270191 0.628571428571429 1.1 1 1 abnormal artery morphology 6.18384890241627e-05 0.00111466116991018 1.45891336270191 0.628571428571429 1.1 1 1 enhanced long term potentiation 5.37031152051263e-07 1.92210790032736e-05 1.45062408223201 0.625 1.1 1 1 overriding aortic valve 3.46145558254935e-06 0.000100706090778848 1.45062408223201 0.625 1.1 1 1 kidney cortex cysts 0.000149859565550186 0.00232258983991332 1.45062408223201 0.625 1.1 1 1 failure of primitive streak formation 0.000149859565550186 0.00232258983991332 1.45062408223201 0.625 1.1 1 1 increased fibroblast apoptosis 0.000149859565550186 0.00232258983991332 1.45062408223201 0.625 1.1 1 1 abnormal cardiac muscle contractility 0.00102235547939302 0.0107758866736871 1.45062408223201 0.625 1.1 1 1 failure of tooth eruption 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal hair follicle orientation 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 delayed hair appearance 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 disorganized retinal layers 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal extraembryonic endoderm formation 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 small epididymis 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 decreased circulating triiodothyronine level 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal pulmonary alveolus wall morphology 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal ear pigmentation 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 pointed snout 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal urination 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal atrial thrombosis 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal hepatobiliary system morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 short ureter 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased corneal stroma thickness 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased susceptibility to age related obesity 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal perineum morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 liver failure 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased cardiac output 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal extraembryonic tissue physiology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 long femur 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal choroid pigmentation 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 non-pigmented tail tip 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 Sertoli cell hypoplasia 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 stomach epithelial hyperplasia 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 absent outer ear 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal cerebellum deep nucleus morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased caudal vertebrae number 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal lateral plate mesoderm morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 pleural effusion 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 sinoatrial block 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 delayed suture closure 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal visual evoked potential 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal stomach position or orientation 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased alveolar lamellar body number 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased aorta wall thickness 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal macrophage activation involved in immune response 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased testis apoptosis 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 absent hypoglossal canal 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal umbilical vein topology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased brain apoptosis 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased basal metabolism 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 hydrops fetalis 1.323421588452e-08 7.15654608972685e-07 1.45062408223201 0.625 1.1 1 1 decreased hemoglobin content 2.11528787673456e-15 4.57545964641498e-13 1.44856645942033 0.624113475177305 1.1 1 1 polyuria 4.95590845417008e-09 3.04390673574027e-07 1.44685622747297 0.623376623376623 1.1 1 1 abnormal hepatocyte morphology 2.83482489315004e-12 3.4398180105906e-10 1.4427828709767 0.621621621621622 1.1 1 1 lethality throughout fetal growth and development, complete penetrance 6.81222711535178e-20 3.38908298988751e-17 1.44146224592318 0.621052631578947 1.1 1 1 short sternum 0.000363968207614174 0.00463105328102434 1.44061977821662 0.620689655172414 1.1 1 1 increased retinal apoptosis 0.000363968207614174 0.00463105328102434 1.44061977821662 0.620689655172414 1.1 1 1 abnormal erythropoiesis 1.56863996294507e-11 1.66042208843654e-09 1.43680861478218 0.619047619047619 1.1 1 1 abnormal reproductive system morphology 1.98283732331008e-05 0.000436487419622462 1.43680861478218 0.619047619047619 1.1 1 1 abnormal eye pigmentation 0.00252105376267121 0.0219653983700338 1.43680861478218 0.619047619047619 1.1 1 1 left pulmonary isomerism 0.00252105376267121 0.0219653983700338 1.43680861478218 0.619047619047619 1.1 1 1 abnormal erythrocyte physiology 0.00252105376267121 0.0219653983700338 1.43680861478218 0.619047619047619 1.1 1 1 abnormal brown adipose tissue morphology 0.000130958357146872 0.00208152660321306 1.43355791655869 0.617647058823529 1.1 1 1 increased circulating alanine transaminase level 9.1183426615631e-09 5.09705109452544e-07 1.42830678865921 0.615384615384615 1.1 1 1 ventricular hypoplasia 0.00088619026512194 0.00952223880989557 1.42830678865921 0.615384615384615 1.1 1 1 abnormal ocular fundus morphology 0.00088619026512194 0.00952223880989557 1.42830678865921 0.615384615384615 1.1 1 1 absent trabeculae carneae 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 excessive scratching 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 abnormal soleus morphology 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 small otic vesicle 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 increased cochlear inner hair cell number 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 abnormal exocrine pancreas morphology 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 increased renin activity 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 increased prostaglandin level 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 absent hypoglossal nerve 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 embryonic lethality between somite formation and embryo turning, complete penetrance 5.76199887516688e-08 2.53680923928807e-06 1.42575624082232 0.614285714285714 1.1 1 1 osteopetrosis 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 absent mature ovarian follicles 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 decreased thymus weight 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 pale kidney 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 abnormal heart shape 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 absent spleen 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal thymus cortex morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal Peyer's patch follicle morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal bile duct morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 acidosis 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal metacarpal bone morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 atrioventricular block 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 primary atelectasis 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 increased effector memory CD4-positive, alpha-beta T cell number 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal metanephric mesenchyme morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal cell differentiation 4.13127153028884e-05 0.000808467844976483 1.41524300705562 0.609756097560976 1.1 1 1 abnormal nasal cavity morphology 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 decreased epididymis weight 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 abnormal corneal stroma morphology 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 abnormal vertebral artery topology 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 pale liver 4.41506945136605e-08 1.99681550186783e-06 1.41141802595547 0.608108108108108 1.1 1 1 kidney cysts 4.41506945136605e-08 1.99681550186783e-06 1.41141802595547 0.608108108108108 1.1 1 1 abnormal trophoblast layer morphology 5.5338898034463e-06 0.000148816766335921 1.41080302899427 0.607843137254902 1.1 1 1 premature aging 0.000763386403262273 0.00836530254676169 1.40917767988253 0.607142857142857 1.1 1 1 abnormal ovarian folliculogenesis 0.000272873133548945 0.00368608986724681 1.40666577670983 0.606060606060606 1.1 1 1 decreased brown adipose tissue amount 0.000272873133548945 0.00368608986724681 1.40666577670983 0.606060606060606 1.1 1 1 dilated heart atrium 0.000272873133548945 0.00368608986724681 1.40666577670983 0.606060606060606 1.1 1 1 impaired branching involved in ureteric bud morphogenesis 9.84710817074585e-05 0.00163297877164869 1.40481490068784 0.605263157894737 1.1 1 1 abnormal vasculogenesis 3.57918532676628e-05 0.000717723771662718 1.40339446095004 0.604651162790698 1.1 1 1 thymus atrophy 1.30828475502149e-05 0.000307014936614712 1.40226994615761 0.604166666666667 1.1 1 1 absent gastric milk in neonates 3.35081354604599e-08 1.60291321072873e-06 1.39855039722881 0.602564102564103 1.1 1 1 abnormal contextual conditioning behavior 4.15787233335996e-06 0.000116866750612801 1.39259911894273 0.6 1.1 1 1 abnormal learning/memory/conditioning 4.15787233335996e-06 0.000116866750612801 1.39259911894273 0.6 1.1 1 1 abnormal interventricular septum morphology 1.13112612545249e-05 0.000275850611476772 1.39259911894273 0.6 1.1 1 1 increased B cell derived lymphoma incidence 1.13112612545249e-05 0.000275850611476772 1.39259911894273 0.6 1.1 1 1 abnormal embryonic epiblast morphology 0.000234638159330934 0.00333521383620399 1.39259911894273 0.6 1.1 1 1 holoprosencephaly 0.000234638159330934 0.00333521383620399 1.39259911894273 0.6 1.1 1 1 decreased circulating thyroxine level 0.000234638159330934 0.00333521383620399 1.39259911894273 0.6 1.1 1 1 abnormal primitive streak morphology 0.00184671515290932 0.0171153901812462 1.39259911894273 0.6 1.1 1 1 increased pre-B cell number 0.00184671515290932 0.0171153901812462 1.39259911894273 0.6 1.1 1 1 absent mesoderm 1.53368533418839e-06 4.92263518554015e-05 1.39259911894273 0.6 1.1 1 1 muscular ventricular septal defect 1.53368533418839e-06 4.92263518554015e-05 1.39259911894273 0.6 1.1 1 1 emphysema 0.000654386499440304 0.00744982342040163 1.39259911894273 0.6 1.1 1 1 abnormal hyoid bone morphology 0.0053002610491579 0.0381603454696969 1.39259911894273 0.6 1.1 1 1 absent placental labyrinth 0.0053002610491579 0.0381603454696969 1.39259911894273 0.6 1.1 1 1 abnormal heart electrocardiography waveform feature 0.0053002610491579 0.0381603454696969 1.39259911894273 0.6 1.1 1 1 vagina atresia 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal seizure response to electrical stimulation 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 increased airway responsiveness 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal lymph node B cell domain morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal olfactory nerve morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal Muller cell morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal aorta wall morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 lactation failure 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 enlarged testis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal prostate gland epithelium morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal epidermis suprabasal layer morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal immune cell physiology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 decreased incidence of induced tumors 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 ketoaciduria 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 acrania 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 cochlear ganglion hypoplasia 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 absent seminal vesicle 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal glial cell physiology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal pillar cell morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal ear physiology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased heart rate variability 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal embryonic erythrocyte morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal corneal endothelium morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased susceptibility to atherosclerosis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 osteosclerosis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 vascular smooth muscle hyperplasia 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased platelet aggregation 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal spinal cord dorsal column morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal sperm principal piece morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 decreased transitional stage T2 B cell number 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased circulating fructosamine level 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal heart and great artery attachment 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal left subclavian artery morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 thin ventricle myocardium compact layer 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 thick aortic valve cusps 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal adaptive thermogenesis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased fatty acid oxidation 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 decreased cardiac muscle contractility 4.26214139151726e-10 3.26217744966129e-08 1.38367220151361 0.596153846153846 1.1 1 1 pulmonary hypoplasia 2.66008780787189e-05 0.00055839395966931 1.38272252944668 0.595744680851064 1.1 1 1 hydronephrosis 2.18286663982939e-08 1.09694560940921e-06 1.38154674498287 0.595238095238095 1.1 1 1 spina bifida 7.29073359937521e-05 0.00128894510027339 1.38154674498287 0.595238095238095 1.1 1 1 increased brown adipose tissue amount 0.000201044565477226 0.00298566183059462 1.38005318093424 0.594594594594595 1.1 1 1 impaired skeletal muscle contractility 0.000201044565477226 0.00298566183059462 1.38005318093424 0.594594594594595 1.1 1 1 increased lymphocyte cell number 4.23735742498062e-07 1.5275980571941e-05 1.37914405499159 0.594202898550725 1.1 1 1 polydipsia 0.000558762649761044 0.00652545582760844 1.37809287812041 0.59375 1.1 1 1 edema 1.90146350522895e-15 4.50465758976859e-13 1.37640610593177 0.593023255813954 1.1 1 1 increased circulating creatinine level 1.88588924592736e-08 9.77322812342562e-07 1.37640610593177 0.593023255813954 1.1 1 1 abnormal trigeminal ganglion morphology 0.00156933917774541 0.0155217940542414 1.37540653722739 0.592592592592593 1.1 1 1 increased brain weight 0.00156933917774541 0.0155217940542414 1.37540653722739 0.592592592592593 1.1 1 1 decreased urine osmolality 2.28390060336631e-05 0.000491879026049671 1.37365219215439 0.591836734693878 1.1 1 1 abnormal tail movements 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 increased coping response 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal vascular branching morphogenesis 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal cochlear sensory epithelium morphology 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal circulating lipid level 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 embryonic lethality before implantation, incomplete penetrance 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal vascular development 9.84045812808732e-07 3.33035912838329e-05 1.37149913229208 0.590909090909091 1.1 1 1 abnormal heart looping 0.00017175023416437 0.00262103501523847 1.36879400579841 0.58974358974359 1.1 1 1 enlarged liver sinusoidal spaces 0.00047560852840905 0.00566065174362446 1.36529325386542 0.588235294117647 1.1 1 1 distended urinary bladder 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 decreased vasoconstriction 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 aminoaciduria 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 increased regulatory T cell number 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 abnormal ectoplacental cone morphology 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 cleft palate 9.37013443533632e-12 1.05946406399541e-09 1.36425104527469 0.587786259541985 1.1 1 1 abnormal inner ear morphology 5.33795851224581e-05 0.000978830654881549 1.36232522505267 0.58695652173913 1.1 1 1 abnormal cell death 5.33795851224581e-05 0.000978830654881549 1.36232522505267 0.58695652173913 1.1 1 1 failure to gastrulate 5.33795851224581e-05 0.000978830654881549 1.36232522505267 0.58695652173913 1.1 1 1 perinatal lethality, complete penetrance 4.47357925819524e-18 1.48373712063476e-15 1.36208834012395 0.586854460093897 1.1 1 1 abnormal mammary gland development 0.000146358396086771 0.00228972647965938 1.3586332867734 0.585365853658537 1.1 1 1 palatal shelves fail to meet at midline 0.000146358396086771 0.00228972647965938 1.3586332867734 0.585365853658537 1.1 1 1 atrioventricular septal defect 1.67262815973072e-05 0.000376530547269697 1.35756517884354 0.584905660377358 1.1 1 1 increased spleen weight 4.03612431573844e-10 3.1374560110623e-08 1.3556274609177 0.584070796460177 1.1 1 1 reduced long term depression 0.000403786952835803 0.00503468694325344 1.35391581008321 0.583333333333333 1.1 1 1 abnormal trophoblast giant cell morphology 0.000403786952835803 0.00503468694325344 1.35391581008321 0.583333333333333 1.1 1 1 abnormal adrenal gland morphology 0.00376187052029121 0.0294729225802342 1.35391581008321 0.583333333333333 1.1 1 1 abnormal impulse conducting system conduction 0.00376187052029121 0.0294729225802342 1.35391581008321 0.583333333333333 1.1 1 1 increased hemangiosarcoma incidence 0.00376187052029121 0.0294729225802342 1.35391581008321 0.583333333333333 1.1 1 1 mesocardia 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal superior cervical ganglion morphology 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal mating frequency 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 impaired embryo implantation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal embryonic growth/weight/body size 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 altered tumor susceptibility 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal respiratory function 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal corticospinal tract morphology 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 decreased synaptic depression 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal aorta elastic fiber morphology 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 loss of dopaminergic neurons 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal vascular endothelial cell development 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal defecation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal rostral-caudal body axis extension 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 increased hepatocyte proliferation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 decreased renal glomerular filtration rate 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 decreased keratinocyte proliferation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 impaired macrophage phagocytosis 0.000124456617557765 0.00199732797532219 1.3494177509135 0.581395348837209 1.1 1 1 lethality throughout fetal growth and development, incomplete penetrance 6.92268974728092e-15 1.23001362474009e-12 1.34851311331512 0.581005586592179 1.1 1 1 increased tumor incidence 9.59797738638677e-11 8.68180681768622e-09 1.34767656671877 0.580645161290323 1.1 1 1 abnormal cranial ganglia morphology 0.00112295426918878 0.0117614683983457 1.34767656671877 0.580645161290323 1.1 1 1 microcephaly 1.42734336208977e-06 4.67173238578725e-05 1.34550639511375 0.579710144927536 1.1 1 1 absent vitelline blood vessels 1.21630047023887e-05 0.000288147373306589 1.34373599196228 0.578947368421053 1.1 1 1 persistence of hyaloid vascular system 0.000342083105660654 0.00439757997587017 1.34373599196228 0.578947368421053 1.1 1 1 abnormal stationary movement 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 abnormal neural crest cell migration 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 increased liver cholesterol level 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 decreased susceptibility to weight gain 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 right-sided stomach 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 small placenta 0.000105641069172073 0.00171753045467668 1.3410213737967 0.577777777777778 1.1 1 1 small liver 3.87609126154579e-07 1.40755868804309e-05 1.33903761436801 0.576923076923077 1.1 1 1 decreased kidney weight 3.29445986733307e-05 0.000668977054693145 1.33903761436801 0.576923076923077 1.1 1 1 abnormal kidney cortex morphology 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 abnormal ureter morphology 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 thick skin 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 abnormal erythrocyte osmotic lysis 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 pulmonary edema 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 decreased Peyer's patch number 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 abnormal skin morphology 3.26965645532597e-06 9.62517210961344e-05 1.33633248787434 0.575757575757576 1.1 1 1 increased osteoblast cell number 0.000946755564620326 0.0100858863682786 1.33633248787434 0.575757575757576 1.1 1 1 myeloid hyperplasia 0.000946755564620326 0.0100858863682786 1.33633248787434 0.575757575757576 1.1 1 1 abnormal cell nucleus morphology 8.95308396315055e-05 0.00150478353772547 1.33333958196644 0.574468085106383 1.1 1 1 abnormal nervous system physiology 1.12173029522357e-09 7.8600115756863e-08 1.33205133116261 0.573913043478261 1.1 1 1 abnormal dermal layer morphology 0.00079690235384653 0.00869427458418089 1.32628487518355 0.571428571428571 1.1 1 1 decreased glycogen level 0.00079690235384653 0.00869427458418089 1.32628487518355 0.571428571428571 1.1 1 1 increased bone resorption 0.00264394287705625 0.0226614430658477 1.32628487518355 0.571428571428571 1.1 1 1 decreased circulating progesterone level 0.00264394287705625 0.0226614430658477 1.32628487518355 0.571428571428571 1.1 1 1 increased triglyceride level 0.00264394287705625 0.0226614430658477 1.32628487518355 0.571428571428571 1.1 1 1 abnormal hematopoietic system physiology 0.00900587076447347 0.0560753530078292 1.32628487518355 0.571428571428571 1.1 1 1 liver degeneration 0.00900587076447347 0.0560753530078292 1.32628487518355 0.571428571428571 1.1 1 1 absent segment of posterior cerebral artery 0.00900587076447347 0.0560753530078292 1.32628487518355 0.571428571428571 1.1 1 1 megacephaly 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 irregularly shaped pupil 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 absent visceral yolk sac blood islands 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 increased lactate dehydrogenase level 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 enlarged stomach 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 lysosomal protein accumulation 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 abnormal glucose tolerance 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 spina bifida occulta 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 increased stomach tumor incidence 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 increased lung compliance 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 decreased compact bone area 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 testis degeneration 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 double outlet right ventricle 6.71062309384048e-09 3.92768822257134e-07 1.32318607874621 0.570093457943925 1.1 1 1 abnormal liver physiology 2.08920067758721e-08 1.06058911948943e-06 1.32296916299559 0.57 1.1 1 1 decreased B cell proliferation 6.38224062171754e-07 2.25188986475495e-05 1.32208777114816 0.569620253164557 1.1 1 1 abnormal cued conditioning behavior 6.40589582769579e-05 0.00115051739143634 1.31978347873658 0.568627450980392 1.1 1 1 decreased macrophage cell number 0.000206033037923659 0.00302364119076757 1.31874916566547 0.568181818181818 1.1 1 1 increased erythroid progenitor cell number 0.000669886336243939 0.00757930322426216 1.31732349089177 0.567567567567568 1.1 1 1 abnormal lactation 0.00221171499403287 0.0200059674460246 1.31523250122369 0.566666666666667 1.1 1 1 pallor 3.01658387850535e-13 4.54772872592852e-11 1.31302202643172 0.565714285714286 1.1 1 1 decreased spleen weight 4.54126218178735e-06 0.000126925726710068 1.31186873523591 0.565217391304348 1.1 1 1 abnormal vitelline vasculature morphology 3.50688963723827e-09 2.20845265129878e-07 1.31186873523591 0.565217391304348 1.1 1 1 abnormal myelin sheath morphology 0.000173580998436573 0.00263282154640838 1.31186873523591 0.565217391304348 1.1 1 1 atrial septal defect 0.000173580998436573 0.00263282154640838 1.31186873523591 0.565217391304348 1.1 1 1 abnormal cardiovascular development 0.00747410315996743 0.0499780419634919 1.31186873523591 0.565217391304348 1.1 1 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.00747410315996743 0.0499780419634919 1.31186873523591 0.565217391304348 1.1 1 1 abnormal heart ventricle morphology 1.22157954444552e-06 4.0515721557443e-05 1.30928122293761 0.564102564102564 1.1 1 1 decreased trabecular bone volume 0.0005625138805382 0.00655387952149308 1.30928122293761 0.564102564102564 1.1 1 1 decreased liver weight 3.84157412884501e-06 0.000109838110867839 1.307604806519 0.563380281690141 1.1 1 1 vertebral transformation 0.000146108335248067 0.00228972647965938 1.30556167400881 0.5625 1.1 1 1 increased circulating follicle stimulating hormone level 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 abnormal heart atrium morphology 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 increased fatty acid level 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 abnormal auditory brainstem response waveform shape 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 absent mandible 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 vasculature congestion 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 mixed cellular infiltration to dermis 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 small pancreas 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 increased cochlear outer hair cell number 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 blepharitis 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 dystonia 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 increased heart left ventricle size 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 increased hepatocellular carcinoma incidence 3.84850496996204e-05 0.000762801283886899 1.30301671947858 0.56140350877193 1.1 1 1 liver fibrosis 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 hemopericardium 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 increased bone trabecula number 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 lethality at weaning, incomplete penetrance 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 respiratory distress 1.07990446887897e-12 1.40710954426649e-10 1.30136911885785 0.560693641618497 1.1 1 1 decreased erythrocyte cell number 1.21203130974853e-11 1.33996794799976e-09 1.30094185209087 0.560509554140127 1.1 1 1 small ovary 2.36584180733911e-07 8.84967142218954e-06 1.30077939681464 0.56043956043956 1.1 1 1 kyphosis 3.74233211683153e-11 3.79961271045651e-09 1.29975917767988 0.56 1.1 1 1 decreased heart rate 6.4229266103166e-08 2.75466033502803e-06 1.29975917767988 0.56 1.1 1 1 decreased oocyte number 0.000122888578463309 0.00197854588302576 1.29975917767988 0.56 1.1 1 1 ruffled hair 0.00619934098786816 0.0432003932122688 1.29975917767988 0.56 1.1 1 1 diaphragmatic hernia 0.00619934098786816 0.0432003932122688 1.29975917767988 0.56 1.1 1 1 impaired conditioned place preference behavior 0.00619934098786816 0.0432003932122688 1.29975917767988 0.56 1.1 1 1 ventricular septal defect 3.57277652764693e-10 2.86686503629733e-08 1.29702859117215 0.558823529411765 1.1 1 1 pericardial edema 8.63637985339575e-06 0.000221474174075484 1.29702859117215 0.558823529411765 1.1 1 1 decreased mean corpuscular hemoglobin 8.63637985339575e-06 0.000221474174075484 1.29702859117215 0.558823529411765 1.1 1 1 kidney failure 0.000395665595912868 0.00497079883754171 1.29544104087696 0.558139534883721 1.1 1 1 neonatal lethality, incomplete penetrance 5.9747505152493e-18 1.74849316549208e-15 1.29440302722241 0.557692307692308 1.1 1 1 increased susceptibility to injury 0.000103290107342401 0.00169593493078694 1.29440302722241 0.557692307692308 1.1 1 1 decreased circulating cholesterol level 4.72953057806707e-13 6.72268989310963e-11 1.29367131267904 0.557377049180328 1.1 1 1 impaired fertilization 7.28126329234244e-06 0.000192682366379807 1.29312775330396 0.557142857142857 1.1 1 1 abnormal response to infection 1.9549407221611e-06 6.11687427217073e-05 1.29270804290043 0.556962025316456 1.1 1 1 decreased bone mineral density 3.63218217039585e-18 1.29072187840853e-15 1.29138264162609 0.556390977443609 1.1 1 1 respiratory failure 5.94794568154808e-11 5.58321316333994e-09 1.29115150100651 0.556291390728477 1.1 1 1 irregular heartbeat 0.000331522998863142 0.00428396602427047 1.28944362865068 0.555555555555556 1.1 1 1 decreased circulating serum albumin level 1.2075709046429e-07 5.00638770883202e-06 1.28944362865068 0.555555555555556 1.1 1 1 abnormal osteoblast physiology 8.67673008443098e-05 0.00147298451912628 1.28944362865068 0.555555555555556 1.1 1 1 abnormal fetal cardiomyocyte proliferation 0.0051405001184846 0.0372256012947029 1.28944362865068 0.555555555555556 1.1 1 1 thick interventricular septum 0.0051405001184846 0.0372256012947029 1.28944362865068 0.555555555555556 1.1 1 1 delayed kidney development 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 right pulmonary isomerism 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 absent allantois 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 abnormal eye anterior chamber morphology 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 darkened coat color 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 increased gastrointestinal tumor incidence 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 abnormal hypoglossal nerve topology 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 abnormal head movements 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 synostosis 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 absent parathyroid glands 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal sympathetic neuron morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal vagina orifice morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 multifocal hepatic necrosis 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal lung volume 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal gut-associated lymphoid tissue morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal posterior semicircular canal morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal NMDA-mediated synaptic currents 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal postural reflex 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 decreased circulating bicarbonate level 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 genetic imprinting 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal lens capsule morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal abdominal wall morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 premature bone ossification 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 decreased fear-related response 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal thymus physiology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal posterior eye segment morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal inguinal fat pad morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal liver vasculature morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal hyoid bone lesser horn morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal hippocampus granule cell morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal ventricle myocardium morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 shortened ST segment 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 fusion of atlas and occipital bones 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal pulmonary alveolar system morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 reduced AMPA-mediated synaptic currents 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal infrahyoid muscle connection 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 symmetric azygos veins 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 cerebellum atrophy 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 increased bone mineralization 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 decreased platelet dense granule number 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 small seminiferous tubules 5.16789223937574e-06 0.00014204565685577 1.28595864587054 0.554054054054054 1.1 1 1 abnormal bone mineralization 6.39406996981868e-09 3.8325901325118e-07 1.28518100508489 0.553719008264463 1.1 1 1 increased respiratory quotient 0.000277643099814276 0.00368608986724681 1.28395663448621 0.553191489361702 1.1 1 1 decreased bone trabecula number 0.000277643099814276 0.00368608986724681 1.28395663448621 0.553191489361702 1.1 1 1 decreased birth body size 1.97807800276085e-08 1.01452969729229e-06 1.28265708323673 0.552631578947368 1.1 1 1 increased bone marrow cell number 0.00107481973872917 0.0112810721522735 1.28265708323673 0.552631578947368 1.1 1 1 internal hemorrhage 1.62486513441239e-05 0.000369118906105098 1.28174545773336 0.552238805970149 1.1 1 1 decreased white adipose tissue amount 1.62486513441239e-05 0.000369118906105098 1.28174545773336 0.552238805970149 1.1 1 1 embryonic lethality during organogenesis, incomplete penetrance 1.85669381384082e-15 4.50465758976859e-13 1.28159484134585 0.552173913043478 1.1 1 1 enlarged spleen 5.77213444099761e-19 2.20895144953563e-16 1.28138460597161 0.552083333333333 1.1 1 1 dermatitis 6.11405982581924e-05 0.00111012582603835 1.28055091397033 0.551724137931034 1.1 1 1 abnormal cornea morphology 3.66174297552709e-06 0.000105301568226863 1.27952483150721 0.551282051282051 1.1 1 1 abnormal excitatory postsynaptic currents 3.66174297552709e-06 0.000105301568226863 1.27952483150721 0.551282051282051 1.1 1 1 organ of Corti degeneration 0.000232425774217898 0.0033323291836716 1.27891755821271 0.551020408163265 1.1 1 1 abnormal long bone hypertrophic chondrocyte zone 0.000232425774217898 0.0033323291836716 1.27891755821271 0.551020408163265 1.1 1 1 perimembraneous ventricular septal defect 1.36562015153673e-05 0.000317474778219403 1.27823107535806 0.550724637681159 1.1 1 1 anophthalmia 8.31423470192386e-07 2.84608335517355e-05 1.27785312412348 0.550561797752809 1.1 1 1 increased bone mineral content 5.16462611975403e-08 2.31477612124111e-06 1.27761387058966 0.55045871559633 1.1 1 1 intracranial hemorrhage 5.12930424671425e-05 0.000952174948783708 1.27654919236417 0.55 1.1 1 1 abnormal skin pigmentation 0.00089644628395753 0.00961168160062222 1.27654919236417 0.55 1.1 1 1 decreased myocardial infarction size 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 decreased circulating VLDL cholesterol level 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 abnormal sperm mitochondrial sheath morphology 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 increased skin tumor incidence 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 decreased IgG level 4.353682203943e-08 1.99681550186783e-06 1.27550369753013 0.54954954954955 1.1 1 1 increased grip strength 6.99997744576486e-07 2.43530683864896e-05 1.27527391844572 0.549450549450549 1.1 1 1 abnormal CD4-positive, alpha-beta T cell physiology 1.1473384460355e-05 0.000277087804321679 1.27491468635602 0.549295774647887 1.1 1 1 abnormal extraembryonic tissue morphology 1.59925982914638e-07 6.31453781746289e-06 1.27427370360773 0.549019607843137 1.1 1 1 abnormal dendritic spine morphology 0.000194507246516257 0.00290592658083598 1.27427370360773 0.549019607843137 1.1 1 1 hemorrhage 2.07052773388093e-15 4.57545964641498e-13 1.27408004499016 0.548936170212766 1.1 1 1 increased eosinophil cell number 4.30173874584943e-05 0.000826299237861039 1.27280564634551 0.548387096774194 1.1 1 1 pericardial effusion 4.30173874584943e-05 0.000826299237861039 1.27280564634551 0.548387096774194 1.1 1 1 abnormal intestine physiology 0.00353378158848641 0.0284015563856541 1.27280564634551 0.548387096774194 1.1 1 1 abnormal seminiferous tubule morphology 4.50608329132565e-10 3.39663096580986e-08 1.2717800172993 0.547945205479452 1.1 1 1 decreased bone marrow cell number 9.63645746438661e-06 0.000242128161036987 1.2717800172993 0.547945205479452 1.1 1 1 abnormal fertility/fecundity 9.63645746438661e-06 0.000242128161036987 1.2717800172993 0.547945205479452 1.1 1 1 skin edema 0.000747511495874482 0.00820942536859944 1.27102300538424 0.547619047619048 1.1 1 1 increased circulating bilirubin level 0.000162729452317271 0.00251422057539884 1.26998032859557 0.547169811320755 1.1 1 1 decreased lymphocyte cell number 5.9976551926879e-09 3.63882129068565e-07 1.26929607195301 0.546875 1.1 1 1 decreased circulating LDL cholesterol level 3.60665211890813e-05 0.000717723771662718 1.26929607195301 0.546875 1.1 1 1 decreased caudal vertebrae number 3.60665211890813e-05 0.000717723771662718 1.26929607195301 0.546875 1.1 1 1 abnormal neurocranium morphology 8.09134882654403e-06 0.000211033948830296 1.26881253059227 0.546666666666667 1.1 1 1 muscular atrophy 0.000623224665499917 0.00717718220106965 1.26599919903885 0.545454545454545 1.1 1 1 abnormal locomotor coordination 0.0029302490096237 0.024337210054888 1.26599919903885 0.545454545454545 1.1 1 1 abnormal T cell subpopulation ratio 0.0029302490096237 0.024337210054888 1.26599919903885 0.545454545454545 1.1 1 1 cardiovascular system phenotype 0.0029302490096237 0.024337210054888 1.26599919903885 0.545454545454545 1.1 1 1 abnormal long bone epiphysis morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 aphakia 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal lysosome physiology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal basement membrane morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 cleft upper lip 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal mesenteric lymph node morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal cerebral cortex pyramidal cell morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 increased mast cell number 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal large intestine morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal sebaceous gland morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 social withdrawal 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 failure of somite differentiation 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 retinal detachment 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 rectal hemorrhage 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal coronal suture morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 enlarged placenta 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal spinal cord ventral horn morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 increased glycogen level 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 increased circulating triiodothyronine level 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 enhanced behavioral response to addictive substance 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 palatal shelf hypoplasia 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 decreased core body temperature 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 decreased embryonic cilium length 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 hypolactation 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 thin hypoglossal nerve 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 increased leukocyte cell number 8.28179079718123e-10 5.97129119072125e-08 1.2645440275457 0.544827586206897 1.1 1 1 increased blood urea nitrogen level 8.28179079718123e-10 5.97129119072125e-08 1.2645440275457 0.544827586206897 1.1 1 1 decreased circulating glucose level 1.72291821975204e-17 4.7619545240369e-15 1.26448665519292 0.544802867383513 1.1 1 1 abnormal nervous system morphology 5.70042344482537e-06 0.000152471003430141 1.26332831465269 0.544303797468354 1.1 1 1 abnormal blood homeostasis 5.68526656979408e-08 2.52537510577906e-06 1.26229744699487 0.543859649122807 1.1 1 1 increased macrophage cell number 0.000113826316690308 0.00183859066731909 1.26229744699487 0.543859649122807 1.1 1 1 abnormal sleep pattern 0.000519549189847149 0.00612501710779518 1.26141224541914 0.543478260869565 1.1 1 1 embryonic lethality between implantation and placentation, complete penetrance 0.000519549189847149 0.00612501710779518 1.26141224541914 0.543478260869565 1.1 1 1 abnormal neural tube morphology 1.14553531512683e-10 1.01768539156357e-08 1.26078932579177 0.54320987654321 1.1 1 1 ovary cysts 0.00243017616524962 0.0217057924993121 1.25997063142438 0.542857142857143 1.1 1 1 increased red blood cell distribution width 0.00243017616524962 0.0217057924993121 1.25997063142438 0.542857142857143 1.1 1 1 impaired adaptive thermogenesis 0.00243017616524962 0.0217057924993121 1.25997063142438 0.542857142857143 1.1 1 1 abnormal neural tube closure 4.01264001570008e-06 0.000114073623303474 1.25837269783982 0.542168674698795 1.1 1 1 abnormal forebrain development 1.7781617789613e-05 0.000396697526920739 1.25720753793441 0.541666666666667 1.1 1 1 small lymph nodes 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal tumor morphology 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal retinal ganglion layer morphology 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal lung saccule morphology 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal cardiovascular system physiology 6.55113082133289e-09 3.87998521858704e-07 1.25648040806863 0.541353383458647 1.1 1 1 decreased hematocrit 1.27337444234887e-09 8.67813404203514e-08 1.25588276708306 0.541095890410959 1.1 1 1 embryonic lethality during organogenesis, complete penetrance 9.747661912978e-33 1.21236545042664e-29 1.25582599118943 0.541071428571429 1.1 1 1 abnormal long bone morphology 7.9568631448464e-05 0.00139877717829014 1.25562215642377 0.540983606557377 1.1 1 1 abnormal intestine morphology 1.4893593023223e-05 0.000344630815304812 1.25459380084931 0.540540540540541 1.1 1 1 abnormal breathing pattern 0.00201583809789349 0.0185033109539116 1.25459380084931 0.540540540540541 1.1 1 1 abnormal calcium ion homeostasis 0.00201583809789349 0.0185033109539116 1.25459380084931 0.540540540540541 1.1 1 1 anemia 3.6212834247545e-13 5.29878971710401e-11 1.2539992066309 0.540284360189573 1.1 1 1 kidney inflammation 0.000361012917060243 0.00461706751253138 1.25333920704846 0.54 1.1 1 1 abnormal eye morphology 3.89386976678268e-09 2.42150026121798e-07 1.25233733717872 0.539568345323741 1.1 1 1 abnormal testis morphology 8.71968170636692e-08 3.67630648213351e-06 1.25132094745579 0.539130434782609 1.1 1 1 decreased circulating HDL cholesterol level 1.68646146685027e-08 8.83173241850538e-07 1.25116327092511 0.5390625 1.1 1 1 increased insulin sensitivity 2.75084291120515e-09 1.77733032249943e-07 1.24976844007681 0.538461538461538 1.1 1 1 distended pericardium 0.000300927242219089 0.00395016630617405 1.24976844007681 0.538461538461538 1.1 1 1 abnormal brain wave pattern 0.000300927242219089 0.00395016630617405 1.24976844007681 0.538461538461538 1.1 1 1 increased vascular permeability 0.00167250990661865 0.0162197598156487 1.24976844007681 0.538461538461538 1.1 1 1 decreased B-1 B cell number 0.00167250990661865 0.0162197598156487 1.24976844007681 0.538461538461538 1.1 1 1 abnormal Mullerian duct morphology 0.0097492966859614 0.0591496963568999 1.24976844007681 0.538461538461538 1.1 1 1 decreased bone resorption 0.0097492966859614 0.0591496963568999 1.24976844007681 0.538461538461538 1.1 1 1 short premaxilla 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 absent teeth 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal renal/urinary system morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 small trigeminal ganglion 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal grip strength 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal pulmonary alveolus epithelial cell morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 dystrophic cardiac calcinosis 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal tail bud morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal telomere length 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 axonal dystrophy 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal vestibulocochlear ganglion morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 increased circulating thyroid-stimulating hormone level 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal vertebral arch development 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 increased circulating thyroxine level 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 increased circulating triglyceride level 2.31168052534342e-09 1.5334147484778e-07 1.24853714112107 0.537931034482759 1.1 1 1 thrombocytopenia 2.31168052534342e-09 1.5334147484778e-07 1.24853714112107 0.537931034482759 1.1 1 1 abnormal lung morphology 6.14776762603718e-08 2.67622396725826e-06 1.24826811781982 0.53781512605042 1.1 1 1 hypoglycemia 1.66355374267043e-06 5.27145214636012e-05 1.24784867288775 0.537634408602151 1.1 1 1 maternal effect 4.6468873898715e-05 0.000869107697917695 1.24710368860543 0.537313432835821 1.1 1 1 abnormal neuronal precursor proliferation 0.000250845548025908 0.00353528782274473 1.24646217436232 0.537037037037037 1.1 1 1 axon degeneration 0.000250845548025908 0.00353528782274473 1.24646217436232 0.537037037037037 1.1 1 1 abnormal coat/hair pigmentation 1.88253702842209e-07 7.26017187317822e-06 1.24339207048458 0.535714285714286 1.1 1 1 abnormal circulating cholesterol level 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 lymphoid hyperplasia 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 abnormal ovulation 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 hypoxia 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 increased circulating free fatty acid level 3.24572326371629e-05 0.000661781690040514 1.24222456619305 0.535211267605634 1.1 1 1 abnormal cell morphology 1.57890262475098e-07 6.28403244650891e-06 1.24193781075302 0.535087719298246 1.1 1 1 abnormal organ of Corti morphology 0.00115213428083034 0.0120164948577169 1.24146433084042 0.534883720930233 1.1 1 1 decreased oxygen consumption 0.00115213428083034 0.0120164948577169 1.24146433084042 0.534883720930233 1.1 1 1 decreased bone mineral content 2.12804890738267e-12 2.6467608285572e-10 1.23860979329041 0.533653846153846 1.1 1 1 delayed bone ossification 2.26675863908562e-05 0.000490309749106564 1.23786588350465 0.533333333333333 1.1 1 1 spleen hyperplasia 2.26675863908562e-05 0.000490309749106564 1.23786588350465 0.533333333333333 1.1 1 1 increased circulating corticosterone level 0.000956597998799094 0.0101472815437644 1.23786588350465 0.533333333333333 1.1 1 1 abnormal cell migration 0.000956597998799094 0.0101472815437644 1.23786588350465 0.533333333333333 1.1 1 1 liver inflammation 9.31041393901775e-08 3.89237893669019e-06 1.23786588350465 0.533333333333333 1.1 1 1 abnormal kidney development 0.000145324717343257 0.00228972647965938 1.23786588350465 0.533333333333333 1.1 1 1 disorganized myocardium 0.0066052952619423 0.045263559129701 1.23786588350465 0.533333333333333 1.1 1 1 abnormal spleen marginal zone morphology 0.0066052952619423 0.045263559129701 1.23786588350465 0.533333333333333 1.1 1 1 abnormal synaptic transmission 0.0066052952619423 0.045263559129701 1.23786588350465 0.533333333333333 1.1 1 1 macrocytosis 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal epidermis stratum spinosum morphology 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 no suckling reflex 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal ear development 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal placenta size 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal dendritic cell morphology 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 decreased thymocyte apoptosis 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 liver vascular congestion 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 decreased leukocyte cell number 1.26893517641265e-08 6.93731044247576e-07 1.23673644382992 0.532846715328467 1.1 1 1 embryonic growth arrest 2.07431438193517e-13 3.22491064066484e-11 1.23651450153576 0.532751091703057 1.1 1 1 abnormal heart development 1.223440547977e-09 8.45363434192443e-08 1.23394858640495 0.531645569620253 1.1 1 1 abnormal placenta labyrinth morphology 1.58297082693242e-05 0.000363229577486227 1.23394858640495 0.531645569620253 1.1 1 1 weight loss 1.68185577601957e-10 1.41817499757582e-08 1.2334449339207 0.531428571428571 1.1 1 1 decreased embryo size 4.1867394037335e-26 2.60362856669677e-23 1.23333394773868 0.531380753138075 1.1 1 1 abnormal diaphragm morphology 0.00544394476204805 0.0389692448794087 1.23303046989721 0.53125 1.1 1 1 abnormal depression-related behavior 0.00544394476204805 0.0389692448794087 1.23303046989721 0.53125 1.1 1 1 increased exploration in new environment 1.32282950256503e-05 0.000308970740622583 1.23213502293287 0.530864197530864 1.1 1 1 abnormal liver morphology 1.18430209330996e-10 1.03366717793282e-08 1.23181486312439 0.53072625698324 1.1 1 1 cardiac hypertrophy 1.76316702114341e-06 5.55174425961295e-05 1.23155024124187 0.530612244897959 1.1 1 1 enlarged liver 1.47545689659028e-06 4.79764579120041e-05 1.23012922173275 0.53 1.1 1 1 decreased neutrophil cell number 1.99137124086358e-07 7.62082455638176e-06 1.22993084578988 0.52991452991453 1.1 1 1 prenatal lethality, incomplete penetrance 6.69896532545464e-17 1.75407118390194e-14 1.22921303810186 0.529605263157895 1.1 1 1 cardiac fibrosis 9.23784393234498e-06 0.000235683454171365 1.22876392847888 0.529411764705882 1.1 1 1 lung inflammation 2.26980077107066e-08 1.11804542931451e-06 1.22876392847888 0.529411764705882 1.1 1 1 abnormal oocyte morphology 0.00449029460865142 0.0329973643693365 1.22876392847888 0.529411764705882 1.1 1 1 thin skin 0.00449029460865142 0.0329973643693365 1.22876392847888 0.529411764705882 1.1 1 1 impaired synaptic plasticity 0.00449029460865142 0.0329973643693365 1.22876392847888 0.529411764705882 1.1 1 1 abnormal bone marrow cavity morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal interatrial septum morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 hydroureter 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal cranial suture morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal glutamate-mediated receptor currents 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal embryonic-extraembryonic boundary morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal tendon morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal placenta development 0.000455708766909125 0.00554315676130293 1.22618790347159 0.528301886792453 1.1 1 1 abnormal muscle physiology 6.45140660908213e-06 0.000171635015402051 1.22569585375109 0.528089887640449 1.1 1 1 abnormal lysosome morphology 0.00370639449717041 0.0294729225802342 1.22497144721814 0.527777777777778 1.1 1 1 abnormal B cell differentiation 5.39145281415954e-06 0.000147136870951291 1.2242629617079 0.527472527472527 1.1 1 1 female infertility 1.3179685302731e-14 2.18563114603623e-12 1.22157817451117 0.526315789473684 1.1 1 1 abnormal craniofacial bone morphology 0.000314970061159675 0.00409370522517309 1.22157817451117 0.526315789473684 1.1 1 1 enlarged adrenal glands 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 small superior vagus ganglion 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 flaky skin 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 stereotypic behavior 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 delayed sexual maturation 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 decreased tumor incidence 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 increased liver adenoma incidence 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 abnormal photoreceptor inner segment morphology 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 increased left ventricle weight 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 abnormal blastocyst morphology 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 decreased fertilization frequency 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 reduced female fertility 6.89775990462668e-13 9.27469068257237e-11 1.22052508987797 0.525862068965517 1.1 1 1 increased mean corpuscular hemoglobin 2.63023417248811e-06 7.93055455038082e-05 1.21911033981519 0.525252525252525 1.1 1 1 prenatal lethality, complete penetrance 4.57907789670028e-15 8.76188943695534e-13 1.21894167485395 0.525179856115108 1.1 1 1 decreased circulating phosphate level 0.00253026443692828 0.0219687008267334 1.21852422907489 0.525 1.1 1 1 impaired ovarian folliculogenesis 0.00253026443692828 0.0219687008267334 1.21852422907489 0.525 1.1 1 1 abnormal pulmonary alveolus morphology 2.1983164942471e-06 6.70958561894438e-05 1.21794972448787 0.524752475247525 1.1 1 1 abnormal maternal nurturing 0.000217883156951303 0.00317879385874701 1.21757300016851 0.524590163934426 1.1 1 1 sparse hair 1.97409958561799e-05 0.000436487419622462 1.21710898606783 0.524390243902439 1.1 1 1 arrest of spermatogenesis 1.64723051332748e-05 0.000372498718354738 1.21576113558492 0.523809523809524 1.1 1 1 abnormal stapes morphology 0.0270799785193987 0.122797653292683 1.21576113558492 0.523809523809524 1.1 1 1 embryonic lethality at implantation, complete penetrance 0.0270799785193987 0.122797653292683 1.21576113558492 0.523809523809524 1.1 1 1 increased muscle cell glucose uptake 0.0270799785193987 0.122797653292683 1.21576113558492 0.523809523809524 1.1 1 1 infertility 1.28363069254409e-06 4.22918059298465e-05 1.21472820343914 0.523364485981308 1.1 1 1 increased T cell number 1.14715752375596e-05 0.000277087804321679 1.21324923241223 0.522727272727273 1.1 1 1 abnormal gametogenesis 0.00173141624047795 0.0163523590701601 1.21324923241223 0.522727272727273 1.1 1 1 renal interstitial fibrosis 0.00173141624047795 0.0163523590701601 1.21324923241223 0.522727272727273 1.1 1 1 abnormal cranium morphology 7.12621950650279e-08 3.03016598673944e-06 1.2124619194775 0.522388059701492 1.1 1 1 oxidative stress 9.57426235271194e-06 0.000242128161036987 1.21207701093164 0.522222222222222 1.1 1 1 perinatal lethality, incomplete penetrance 3.0460905063084e-12 3.60816673068673e-10 1.21184879082037 0.52212389380531 1.1 1 1 abnormal cell cycle 6.26697335759178e-07 2.22701374671565e-05 1.21095575560238 0.521739130434783 1.1 1 1 abnormal sternum morphology 0.000104508887058373 0.00171030168787962 1.21095575560238 0.521739130434783 1.1 1 1 abnormal pulmonary artery morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal cranial nerve morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal Wolffian duct morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 dilated heart 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal basicranium morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal ovary morphology 8.70123757904919e-05 0.00147298451912628 1.20953444603007 0.52112676056338 1.1 1 1 atelectasis 8.70123757904919e-05 0.00147298451912628 1.20953444603007 0.52112676056338 1.1 1 1 corneal opacity 8.70123757904919e-05 0.00147298451912628 1.20953444603007 0.52112676056338 1.1 1 1 cyanosis 1.59401375840915e-10 1.36727904277336e-08 1.20885340186001 0.520833333333333 1.1 1 1 abnormal osteoclast morphology 0.00118721334120979 0.0122235738876698 1.20885340186001 0.520833333333333 1.1 1 1 seminiferous tubule degeneration 7.24571674003155e-05 0.00128740859934489 1.20819101643433 0.520547945205479 1.1 1 1 spontaneous skin ulceration 0.0179950622395505 0.0928687081346099 1.20691923641703 0.52 1.1 1 1 abnormal nest building behavior 0.0179950622395505 0.0928687081346099 1.20691923641703 0.52 1.1 1 1 abnormal vertebrae development 0.0179950622395505 0.0928687081346099 1.20691923641703 0.52 1.1 1 1 abnormal leukocyte migration 0.000815528714961624 0.00882548596086975 1.20513385293121 0.519230769230769 1.1 1 1 increased neuron apoptosis 3.48944047482117e-05 0.000705689689521761 1.20348072007397 0.518518518518518 1.1 1 1 abnormal chondrocyte morphology 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 increased cell proliferation 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 diluted coat color 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 abnormal cell adhesion 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 decreased circulating fructosamine level 0.0147126160663211 0.0784515165379929 1.20348072007397 0.518518518518518 1.1 1 1 postnatal lethality, incomplete penetrance 1.67202860940841e-27 1.18833461882955e-24 1.20136191598933 0.517605633802817 1.1 1 1 glomerulosclerosis 0.000465669419464331 0.00563675270519476 1.20051648184718 0.517241379310345 1.1 1 1 abnormal middle ear morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal parietal bone morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal microglial cell morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 decreased granulocyte number 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal spinal nerve morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal outer ear morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal embryonic erythropoiesis 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 increased double-positive T cell number 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal spermatogenesis 8.26986355116893e-10 5.97129119072125e-08 1.19834163314818 0.516304347826087 1.1 1 1 impaired glucose tolerance 1.10306074826921e-12 1.40710954426649e-10 1.19793472597224 0.516129032258065 1.1 1 1 abnormal definitive hematopoiesis 1.17092949067873e-05 0.000281419044257327 1.19793472597224 0.516129032258065 1.1 1 1 abnormal capillary morphology 0.00988157651362854 0.0597337097877302 1.19793472597224 0.516129032258065 1.1 1 1 small cranium 0.00988157651362854 0.0597337097877302 1.19793472597224 0.516129032258065 1.1 1 1 preaxial polydactyly 0.00988157651362854 0.0597337097877302 1.19793472597224 0.516129032258065 1.1 1 1 impaired righting response 9.76500428507511e-06 0.000244125107126878 1.19714661102094 0.515789473684211 1.1 1 1 abnormal myocardial fiber morphology 8.1444257639029e-06 0.000211033948830296 1.19639099565527 0.515463917525773 1.1 1 1 abnormal tail morphology 0.000221612960621968 0.00322375578682542 1.19566591020336 0.515151515151515 1.1 1 1 increased cardiomyocyte apoptosis 0.00811474649899895 0.0522797245773669 1.19566591020336 0.515151515151515 1.1 1 1 decreased circulating alanine transaminase level 0.000184196951400066 0.00278534903712866 1.19463159713224 0.514705882352941 1.1 1 1 thymus hypoplasia 1.27199710894988e-07 5.18193099283665e-06 1.19413692566345 0.514492753623188 1.1 1 1 abnormal kidney morphology 2.92759283302617e-09 1.86727876209041e-07 1.1936563876652 0.514285714285714 1.1 1 1 thick pulmonary interalveolar septum 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 abnormal intestinal goblet cell morphology 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 abnormal midbrain development 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 decreased triglyceride level 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 decreased bone volume 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 abnormal digit morphology 0.000127345531766316 0.00203058980941482 1.19273535650188 0.513888888888889 1.1 1 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.000127345531766316 0.00203058980941482 1.19273535650188 0.513888888888889 1.1 1 1 abnormal pancreatic beta cell physiology 0.00549087069640718 0.039192369748387 1.19186411080684 0.513513513513513 1.1 1 1 abnormal chromosome morphology 0.00549087069640718 0.039192369748387 1.19186411080684 0.513513513513513 1.1 1 1 abnormal retinal pigment epithelium morphology 6.10311638067506e-05 0.00111012582603835 1.18951174743025 0.5125 1.1 1 1 decreased anxiety-related response 7.7597705741629e-07 2.68089295878197e-05 1.18880412592672 0.51219512195122 1.1 1 1 thin ventricular wall 2.44400651995705e-05 0.000519612497298561 1.18628813835862 0.511111111111111 1.1 1 1 decreased insulin secretion 2.44400651995705e-05 0.000519612497298561 1.18628813835862 0.511111111111111 1.1 1 1 abnormal ectoderm development 0.0025414534931422 0.0219890976145782 1.18628813835862 0.511111111111111 1.1 1 1 abnormal myocardial trabeculae morphology 0.0025414534931422 0.0219890976145782 1.18628813835862 0.511111111111111 1.1 1 1 abnormal locomotor behavior 2.036213352139e-05 0.000445167999424544 1.18572751069399 0.510869565217391 1.1 1 1 increased anxiety-related response 1.83685259007147e-07 7.13932940281686e-06 1.18554601252918 0.510791366906475 1.1 1 1 increased monocyte cell number 9.82461188521915e-06 0.000244387220644826 1.18370925110132 0.51 1.1 1 1 small lung 0.00143661928505554 0.0143517689621512 1.18325415335003 0.509803921568627 1.1 1 1 decreased B cell number 2.89016649681804e-10 2.35714398715898e-08 1.18303323211154 0.509708737864078 1.1 1 1 abnormal mesoderm development 0.00118918789178536 0.0122235738876698 1.1823954783476 0.509433962264151 1.1 1 1 abnormal brain morphology 2.54574475903692e-08 1.24167452707928e-06 1.18212347570708 0.509316770186335 1.1 1 1 short snout 4.74973013081418e-06 0.000131277263337781 1.18198999292979 0.509259259259259 1.1 1 1 abnormal head morphology 0.000984862677310342 0.0104027427168131 1.18159925243626 0.509090909090909 1.1 1 1 decreased susceptibility to induced arthritis 0.000816023975130203 0.00882548596086975 1.18085890202746 0.508771929824561 1.1 1 1 premature death 4.61469010759347e-38 7.65269442842584e-35 1.18071702302926 0.508710801393728 1.1 1 1 enlarged heart 2.83200329235046e-11 2.93525341238407e-09 1.1805078738164 0.508620689655172 1.1 1 1 abnormal thoracic vertebrae morphology 0.000676424247552241 0.00757930322426216 1.18016874486672 0.508474576271186 1.1 1 1 increased B cell proliferation 0.000676424247552241 0.00757930322426216 1.18016874486672 0.508474576271186 1.1 1 1 decreased susceptibility to hepatic steatosis 0.000465342104783324 0.00563675270519476 1.17891988905205 0.507936507936508 1.1 1 1 decreased T cell proliferation 1.28116082837971e-07 5.18193099283665e-06 1.17618168829623 0.506756756756757 1.1 1 1 abnormal somite development 0.000105585796996755 0.00171753045467668 1.17518912990948 0.506329113924051 1.1 1 1 embryonic lethality between implantation and somite formation, complete penetrance 1.38290296485282e-11 1.49563961959625e-09 1.17470946087686 0.506122448979592 1.1 1 1 abnormal lipid level 7.30618127190142e-05 0.00128894510027339 1.1744811846505 0.506024096385542 1.1 1 1 increased startle reflex 4.21203496102136e-05 0.000815364744400048 1.17353858337871 0.50561797752809 1.1 1 1 alopecia 2.43224303303184e-05 0.000519612497298561 1.17271504753072 0.505263157894737 1.1 1 1 abnormal dendritic cell physiology 8.14384942181514e-06 0.000211033948830296 1.17134505331632 0.504672897196262 1.1 1 1 abnormal embryo size 4.72060039289812e-06 0.000131201044439487 1.17076917079256 0.504424778761062 1.1 1 1 preweaning lethality, incomplete penetrance 5.88932248658198e-18 1.74849316549208e-15 1.16901148533905 0.503667481662592 1.1 1 1 abnormal blood vessel morphology 2.61261814509888e-07 9.699832292438e-06 1.16850270899792 0.503448275862069 1.1 1 1 decreased T cell number 6.18624635647638e-08 2.67622396725826e-06 1.16770733575943 0.503105590062112 1.1 1 1 decreased total body fat amount 7.5148688316696e-15 1.28918870474332e-12 1.16744836318552 0.502994011976048 1.1 1 1 decreased cell proliferation 7.16524177264219e-09 4.09736526653965e-07 1.16677223478986 0.502702702702703 1.1 1 1 decreased body weight 1.65704469441885e-51 8.2437973547338e-48 1.16612365641139 0.502423263327948 1.1 1 1 neonatal lethality, complete penetrance 1.3442461930194e-19 5.57302067522628e-17 1.16558917484607 0.50219298245614 1.1 1 1 abnormal immune system physiology 2.69719006260753e-06 8.08344612136896e-05 1.16049926578561 0.5 1.1 1 1 reduced long term potentiation 8.01728230750082e-06 0.000211033948830296 1.16049926578561 0.5 1.1 1 1 cleft secondary palate 4.14390553706539e-05 0.000808467844976483 1.16049926578561 0.5 1.1 1 1 small kidney 7.18585224021399e-05 0.00128134820412418 1.16049926578561 0.5 1.1 1 1 domed cranium 0.000379320453313113 0.00478964277977852 1.16049926578561 0.5 1.1 1 1 short stride length 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 abnormal digestive system physiology 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 decreased circulating alkaline phosphatase level 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 abnormal circulating protein level 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 curly tail 0.00301297543743459 0.0249825880020618 1.16049926578561 0.5 1.1 1 1 abnormal myelopoiesis 0.00442385832036265 0.0329471484188685 1.16049926578561 0.5 1.1 1 1 omphalocele 0.00442385832036265 0.0329471484188685 1.16049926578561 0.5 1.1 1 1 lethality, incomplete penetrance 0.00442385832036265 0.0329471484188685 1.16049926578561 0.5 1.1 1 1 disheveled coat 0.00536682912421877 0.038583778747093 1.16049926578561 0.5 1.1 1 1 myoclonus 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 small superior cervical ganglion 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 abnormal retinal inner nuclear layer morphology 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 abnormal hormone level 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 abnormal brainstem morphology 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 decreased metastatic potential 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 ocular hypertelorism 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 increased stereotypic behavior 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal startle reflex 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 blindness 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal sensory capabilities/reflexes/nociception 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal primitive streak formation 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal facial nerve morphology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 increased activated T cell number 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal oogenesis 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal chorion morphology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal female reproductive system physiology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal blood-brain barrier function 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 decreased circulating estradiol level 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal occipital bone morphology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 failure of palatal shelf elevation 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 rough coat 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 increased adenoma incidence 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal tympanic ring morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal bone marrow cell number 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 decreased mast cell number 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal mouth morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 disorganized yolk sac vascular plexus 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 intraventricular hemorrhage 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal olfaction 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 increased intestinal adenocarcinoma incidence 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal pulmonary elastic fiber morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal epididymis epithelium morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 sepsis 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 impaired behavioral response to addictive substance 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 translucent skin 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 increased aggression towards males 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal adrenal gland secretion 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal fluid regulation 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal kidney medulla morphology 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 decreased coping response 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 absent olfactory bulb 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal uterus development 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal pancreas development 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 decreased CNS synapse formation 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 premature hair loss 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 increased pulmonary respiratory rate 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 pulmonary alveolar hemorrhage 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal vitelline vein topology 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 amyloidosis 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 abnormal enteric nervous system morphology 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 myocarditis 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased papilloma incidence 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased growth rate 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 abnormal AMPA-mediated synaptic currents 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased urine phosphate level 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 stria vascularis degeneration 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 abnormal B cell proliferation 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 hematuria 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased fibrosarcoma incidence 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 prenatal growth retardation 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 ataxia 2.40667604661533e-09 1.57542280683043e-07 1.16049926578561 0.5 1.1 1 1 increased oxygen consumption 8.63652791146032e-05 0.00147298451912628 1.16049926578561 0.5 1.1 1 1 abnormal angiogenesis 0.000261594919641888 0.003635292528543 1.16049926578561 0.5 1.1 1 1 increased granulocyte number 0.000261594919641888 0.003635292528543 1.16049926578561 0.5 1.1 1 1 increased erythrocyte cell number 0.000966251291617578 0.0102278727144627 1.16049926578561 0.5 1.1 1 1 abnormal maxilla morphology 0.00170204508863352 0.0163523590701601 1.16049926578561 0.5 1.1 1 1 abnormal apoptosis 0.00170204508863352 0.0163523590701601 1.16049926578561 0.5 1.1 1 1 decreased tumor growth/size 0.00170204508863352 0.0163523590701601 1.16049926578561 0.5 1.1 1 1 decreased IgA level 0.00205770985514945 0.0188528665365903 1.16049926578561 0.5 1.1 1 1 abnormal forelimb morphology 0.00364952846862863 0.0291435058289365 1.16049926578561 0.5 1.1 1 1 abnormal allantois morphology 0.00364952846862863 0.0291435058289365 1.16049926578561 0.5 1.1 1 1 delayed wound healing 0.00364952846862863 0.0291435058289365 1.16049926578561 0.5 1.1 1 1 increased grooming behavior 0.00792032734029388 0.0522797245773669 1.16049926578561 0.5 1.1 1 1 decreased total retina thickness 0.00792032734029388 0.0522797245773669 1.16049926578561 0.5 1.1 1 1 abnormal uterus morphology 0.00963679848263036 0.0590664486148222 1.16049926578561 0.5 1.1 1 1 abnormal epidermis stratum granulosum morphology 0.00963679848263036 0.0590664486148222 1.16049926578561 0.5 1.1 1 1 abnormal retinal photoreceptor morphology 0.0117391983893464 0.065108709015606 1.16049926578561 0.5 1.1 1 1 overexpanded pulmonary alveoli 0.0117391983893464 0.065108709015606 1.16049926578561 0.5 1.1 1 1 increased metastatic potential 0.0174921851388692 0.0909337733185727 1.16049926578561 0.5 1.1 1 1 abnormal response to new environment 0.0174921851388692 0.0909337733185727 1.16049926578561 0.5 1.1 1 1 enhanced paired-pulse facilitation 0.0174921851388692 0.0909337733185727 1.16049926578561 0.5 1.1 1 1 abnormal leukocyte cell number 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 abnormal Schwann cell morphology 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 small seminal vesicle 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 increased leukemia incidence 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 increased thymocyte apoptosis 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 abnormal vascular regression 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 small gonad 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 increased mammary adenocarcinoma incidence 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal hearing physiology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal fibula morphology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 decreased paired-pulse facilitation 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 decreased skin tensile strength 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal thymocyte activation 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal postnatal subventricular zone morphology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal incus morphology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal response to tactile stimuli 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 lowered ear position 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 underdeveloped hair follicles 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal retinal rod cell morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal white adipose tissue morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 decreased cellular sensitivity to gamma-irradiation 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal body wall morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 decreased activity of thyroid 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal neutrophil morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal anterior eye segment morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal pregnancy 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal macrophage chemotaxis 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 impaired leukocyte tethering or rolling 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 increased adipocyte glucose uptake 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal lateral semicircular canal morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal auchene hair morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 kidney hemorrhage 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 jaundice 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal respiratory mechanics 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 decreased circulating parathyroid hormone level 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal primordial germ cell migration 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 primary sex reversal 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal hypaxial muscle morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 lymphedema 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal hindlimb zeugopod morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 absent pharyngeal arches 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal plasma membrane morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal placental transport 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal cochlear inner hair cell physiology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal gonadal fat pad morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 decreased thyroxine level 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal developmental vascular remodeling 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 crystalluria 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 ventricular premature beat 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal hippocampus neuron morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 aorta stenosis 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal inferior vena cava valve morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 sinus bradycardia 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 fusion of atlas and odontoid process 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal pulmonary interalveolar septum morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 increased compact bone area 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 lethality during fetal growth through weaning, complete penetrance 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 reduced male fertility 3.93402812361245e-10 3.10663331983681e-08 1.15538693421827 0.497797356828194 1.1 1 1 abnormal spatial learning 1.22566651474083e-07 5.0394139758972e-06 1.15337963838815 0.496932515337423 1.1 1 1 increased heart weight 1.06668132405325e-06 3.56157019272813e-05 1.15215035020442 0.496402877697842 1.1 1 1 hyperactivity 2.33905058254873e-15 4.84865693674163e-13 1.15111517468761 0.495956873315364 1.1 1 1 preweaning lethality, complete penetrance 2.99406939035719e-29 2.48258253617117e-26 1.15108981227924 0.495945945945946 1.1 1 1 cataract 5.44184608141459e-06 0.000147136870951291 1.15090836276259 0.495867768595041 1.1 1 1 increased bone mineral density 1.1256127697286e-05 0.000275850611476772 1.15022936077866 0.495575221238938 1.1 1 1 limb grasping 3.39227673663837e-08 1.60729302521675e-06 1.14774652660115 0.494505494505495 1.1 1 1 small spleen 8.39946930754296e-05 0.00146109649667924 1.14774652660115 0.494505494505495 1.1 1 1 hypoactivity 3.1641933784726e-15 6.29674482316048e-13 1.14510802883885 0.493368700265252 1.1 1 1 male infertility 9.1013098792968e-20 4.11627424086378e-17 1.14434917659973 0.493041749502982 1.1 1 1 abnormal embryo development 2.1339899319932e-06 6.55345673559641e-05 1.14343310011229 0.492647058823529 1.1 1 1 decreased monocyte cell number 0.000933369351921057 0.00998604844259626 1.14264543092737 0.492307692307692 1.1 1 1 embryonic lethality, complete penetrance 5.64419502346155e-13 7.79996395603367e-11 1.14230962212126 0.492163009404389 1.1 1 1 increased osteoclast cell number 0.0013584928142407 0.0136260115944505 1.14147468765798 0.491803278688525 1.1 1 1 increased double-negative T cell number 0.0013584928142407 0.0136260115944505 1.14147468765798 0.491803278688525 1.1 1 1 decreased body size 4.42698772407672e-30 4.40485278545634e-27 1.14013962954376 0.491228070175439 1.1 1 1 abnormal embryo turning 0.00239361384240944 0.0215338677504285 1.13939927913496 0.490909090909091 1.1 1 1 abnormal axon morphology 2.70522595959492e-05 0.000565483157520367 1.13900853864143 0.490740740740741 1.1 1 1 enlarged kidney 0.00289406433838897 0.0243314826709083 1.13860305322362 0.490566037735849 1.1 1 1 abnormal thrombosis 0.00350121210947078 0.0281853240204161 1.13774437822119 0.490196078431373 1.1 1 1 improved glucose tolerance 2.21965921143496e-08 1.10428045768889e-06 1.13681560730019 0.489795918367347 1.1 1 1 increased fluid intake 0.0042384285086095 0.0321926440157745 1.13681560730019 0.489795918367347 1.1 1 1 increased susceptibility to pharmacologically induced seizures 8.09262989493368e-05 0.00141763499039771 1.13632219774841 0.489583333333333 1.1 1 1 hepatic necrosis 0.00513440279463064 0.0372256012947029 1.13580779204549 0.48936170212766 1.1 1 1 increased cellular sensitivity to gamma-irradiation 0.00513440279463064 0.0372256012947029 1.13580779204549 0.48936170212766 1.1 1 1 neuron degeneration 0.00513440279463064 0.0372256012947029 1.13580779204549 0.48936170212766 1.1 1 1 small testis 3.95891283730064e-11 3.93911827311414e-09 1.13527102087723 0.489130434782609 1.1 1 1 abnormal ovarian follicle morphology 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 decreased osteoclast cell number 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 abnormal metabolism 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 cardiomyopathy 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 hyperglycemia 0.000168580932158455 0.00259656389315268 1.1341242824723 0.488636363636364 1.1 1 1 abnormal axon guidance 0.00755196679329915 0.0503633174218007 1.13351091076734 0.488372093023256 1.1 1 1 abnormal double-strand DNA break repair 0.00755196679329915 0.0503633174218007 1.13351091076734 0.488372093023256 1.1 1 1 Leydig cell hyperplasia 0.0091707721380285 0.0570307392333647 1.1321944056445 0.48780487804878 1.1 1 1 increased rib number 0.000423913454261098 0.00522022137363604 1.13074287435521 0.487179487179487 1.1 1 1 increased urine protein level 0.000423913454261098 0.00522022137363604 1.13074287435521 0.487179487179487 1.1 1 1 abnormal iris morphology 0.0111473908177767 0.0635260816935156 1.13074287435521 0.487179487179487 1.1 1 1 abnormal bone structure 4.36781583516484e-08 1.99681550186783e-06 1.13043451796733 0.487046632124352 1.1 1 1 increased trabecular bone volume 0.0135645195432629 0.0731132012218126 1.12913442076438 0.486486486486487 1.1 1 1 abnormal neuromuscular synapse morphology 0.000739444336970166 0.00815684163287489 1.12826317506934 0.486111111111111 1.1 1 1 abnormal inflammatory response 0.000739444336970166 0.00815684163287489 1.12826317506934 0.486111111111111 1.1 1 1 increased T cell proliferation 4.47723817321024e-05 0.000851288604424587 1.12796190319349 0.485981308411215 1.1 1 1 abnormal retina morphology 1.43149256212343e-08 7.65771558770329e-07 1.12734214390602 0.485714285714286 1.1 1 1 decreased bone mineralization 0.0165252668499343 0.0862677886447254 1.12734214390602 0.485714285714286 1.1 1 1 abnormal epidermis stratum basale morphology 0.0201587016922304 0.102336266243721 1.12533262136786 0.484848484848485 1.1 1 1 abnormal QRS complex 0.0201587016922304 0.102336266243721 1.12533262136786 0.484848484848485 1.1 1 1 head tossing 0.0201587016922304 0.102336266243721 1.12533262136786 0.484848484848485 1.1 1 1 increased or absent threshold for auditory brainstem response 4.17442114125406e-11 4.07210689759587e-09 1.12435915024211 0.484429065743945 1.1 1 1 increased inflammatory response 0.000133805235361647 0.00212000333096877 1.12385192055027 0.484210526315789 1.1 1 1 decreased litter size 8.50618949588491e-11 7.83672087815323e-09 1.12333025015547 0.483985765124555 1.1 1 1 prenatal lethality 0.00188131379615023 0.0173646310498097 1.12306380559898 0.483870967741935 1.1 1 1 abnormal postnatal growth/weight/body size 0.0246271307250323 0.119648413434605 1.12306380559898 0.483870967741935 1.1 1 1 abnormal CD8-positive, alpha beta T cell morphology 0.0246271307250323 0.119648413434605 1.12306380559898 0.483870967741935 1.1 1 1 abnormal podocyte morphology 0.0246271307250323 0.119648413434605 1.12306380559898 0.483870967741935 1.1 1 1 increased sensitivity to induced morbidity/mortality 1.46129390811123e-07 5.86285257488175e-06 1.12265689842304 0.483695652173913 1.1 1 1 microphthalmia 1.5747433504937e-06 5.02201805686292e-05 1.12257445317824 0.483660130718954 1.1 1 1 abnormal glucose homeostasis 1.74744265749332e-07 6.84529702443251e-06 1.12224104823224 0.483516483516484 1.1 1 1 abnormal eating behavior 0.00227028299416121 0.0204984716804937 1.12181595692609 0.483333333333333 1.1 1 1 abnormal spleen morphology 3.57405203143497e-07 1.30741976885213e-05 1.12048204972404 0.482758620689655 1.1 1 1 abnormal spermiogenesis 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 cochlear ganglion degeneration 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 abnormal embryonic neuroepithelium morphology 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 abnormal enzyme/coenzyme level 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 blood in lymph vessels 0.0301357479632936 0.131976537075164 1.12048204972404 0.482758620689655 1.1 1 1 short tail 0.000402301706526046 0.00503468694325344 1.11855350919095 0.481927710843373 1.1 1 1 postnatal lethality, complete penetrance 5.44653785262389e-14 8.74081477961414e-12 1.11840861884002 0.481865284974093 1.1 1 1 increased circulating alkaline phosphatase level 1.04623402339601e-06 3.51690153134807e-05 1.11751781149725 0.481481481481481 1.1 1 1 decreased heart weight 0.000483659809950477 0.00572906560596101 1.11751781149725 0.481481481481481 1.1 1 1 abnormal small intestine morphology 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 impaired limb coordination 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 neurodegeneration 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 abnormal long bone epiphyseal plate proliferative zone 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 decreased platelet aggregation 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 rectal prolapse 0.0369455958251854 0.150659294451063 1.11751781149725 0.481481481481481 1.1 1 1 wrinkled skin 0.0369455958251854 0.150659294451063 1.11751781149725 0.481481481481481 1.1 1 1 abnormal eye muscle morphology 0.0369455958251854 0.150659294451063 1.11751781149725 0.481481481481481 1.1 1 1 abnormal myocardium layer morphology 0.000581604736091698 0.00676047561228084 1.116429673414 0.481012658227848 1.1 1 1 abnormal snout morphology 0.00483778827087941 0.0353421389832967 1.11586467864001 0.480769230769231 1.1 1 1 abnormal female meiosis 0.00483778827087941 0.0353421389832967 1.11586467864001 0.480769230769231 1.1 1 1 abnormal heart morphology 7.25655046932317e-09 4.10242483919122e-07 1.11528500867708 0.480519480519481 1.1 1 1 postnatal growth retardation 4.98698198388804e-21 2.75669281887144e-18 1.11498949065676 0.480392156862745 1.1 1 1 increased circulating chloride level 0.00585314085189372 0.0415991081973875 1.11407929515419 0.48 1.1 1 1 decreased respiratory quotient 0.00585314085189372 0.0415991081973875 1.11407929515419 0.48 1.1 1 1 decreased placenta weight 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 decreased acute inflammation 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 abnormal energy expenditure 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 abnormal preimplantation embryo development 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 abnormal kidney physiology 0.00708611596325099 0.0480947161216558 1.11214512971121 0.479166666666667 1.1 1 1 increased B cell number 4.02767761195249e-05 0.000792003799188287 1.11090528006828 0.478632478632479 1.1 1 1 abnormal carpal bone morphology 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 bidirectional circling 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal circulating insulin level 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal postnatal growth 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 increased susceptibility to age related obesity 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal B cell morphology 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 increased susceptibility to fungal infection 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal lens development 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal chondrocyte physiology 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 azoospermia 2.0262861137754e-06 6.2712077978738e-05 1.10940810314096 0.477987421383648 1.1 1 1 increased total body fat amount 1.28855496401354e-05 0.00030381805431125 1.10853661209372 0.477611940298507 1.1 1 1 teratozoospermia 0.0003788991262963 0.00478964277977852 1.10774929915899 0.477272727272727 1.1 1 1 osteoporosis 0.0104080658338064 0.0626120042602017 1.10774929915899 0.477272727272727 1.1 1 1 abnormal astrocyte morphology 0.0104080658338064 0.0626120042602017 1.10774929915899 0.477272727272727 1.1 1 1 embryonic lethality, incomplete penetrance 0.0104080658338064 0.0626120042602017 1.10774929915899 0.477272727272727 1.1 1 1 abnormal nervous system electrophysiology 0.000546568153434422 0.00639806250196764 1.10523739598629 0.476190476190476 1.1 1 1 abnormal hair follicle morphology 0.00256813679081634 0.0221429471998463 1.10523739598629 0.476190476190476 1.1 1 1 skin lesions 0.00256813679081634 0.0221429471998463 1.10523739598629 0.476190476190476 1.1 1 1 abnormal cartilage morphology 0.0126289021505827 0.0688157592542706 1.10523739598629 0.476190476190476 1.1 1 1 abnormal optic nerve morphology 0.0126289021505827 0.0688157592542706 1.10523739598629 0.476190476190476 1.1 1 1 abnormal muscle morphology 0.0126289021505827 0.0688157592542706 1.10523739598629 0.476190476190476 1.1 1 1 small ears 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal scapula morphology 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal salivary gland morphology 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal anxiety-related response 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal associative learning 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 dry skin 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal bile salt homeostasis 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 decreased vocalization 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal female reproductive system morphology 0.0153371789133739 0.0816069145390751 1.10247430249633 0.475 1.1 1 1 reduced fertility 1.21204674723131e-05 0.000288147373306589 1.10205685671727 0.474820143884892 1.1 1 1 abnormal motor coordination/ balance 0.000205560231894386 0.00302364119076757 1.10188819175603 0.474747474747475 1.1 1 1 deafness 0.000205560231894386 0.00302364119076757 1.10188819175603 0.474747474747475 1.1 1 1 abnormal CNS synaptic transmission 0.000205560231894386 0.00302364119076757 1.10188819175603 0.474747474747475 1.1 1 1 impaired coordination 8.8161787070881e-12 1.02001137366891e-09 1.10012647161179 0.473988439306358 1.1 1 1 abnormal facial morphology 0.00450757038485039 0.0330754611572724 1.09942035706005 0.473684210526316 1.1 1 1 incomplete somite formation 0.0186442925259351 0.0950362247095564 1.09942035706005 0.473684210526316 1.1 1 1 abnormal retinal outer nuclear layer morphology 0.0186442925259351 0.0950362247095564 1.09942035706005 0.473684210526316 1.1 1 1 abnormal compact bone morphology 0.0186442925259351 0.0950362247095564 1.09942035706005 0.473684210526316 1.1 1 1 abnormal nail morphology 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 short vibrissae 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 decreased grooming behavior 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 decreased chemically-elicited antinociception 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 increased malignant tumor incidence 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 abnormal metatarsal bone morphology 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 abnormal optic vesicle formation 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 absent amnion 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 increased circulating VLDL cholesterol level 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 Leydig cell hypoplasia 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 shortened RR interval 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 lethargy 0.000354590071933837 0.00454661239141969 1.09810683214122 0.473118279569892 1.1 1 1 abnormal platelet physiology 0.00544198981649656 0.0389692448794087 1.09719930583367 0.472727272727273 1.1 1 1 abnormal limb bone morphology 0.022688633283838 0.110989135287211 1.09602708435308 0.472222222222222 1.1 1 1 dehydration 0.00198311566432172 0.0182703711666677 1.09418502202643 0.471428571428571 1.1 1 1 abnormal retinal pigmentation 0.000612363992143202 0.00706847067497083 1.09380390568299 0.471264367816092 1.1 1 1 kinked tail 0.000229934780006586 0.0033157261754573 1.09223460309234 0.470588235294118 1.1 1 1 impaired balance 0.000229934780006586 0.0033157261754573 1.09223460309234 0.470588235294118 1.1 1 1 distended abdomen 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 abnormal gastrulation 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 abnormal cervical vertebrae morphology 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 abnormal gluconeogenesis 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 decreased susceptibility to injury 0.00238626396752802 0.0215066363015433 1.09223460309234 0.470588235294118 1.1 1 1 abnormal endoderm development 0.0276427046281272 0.124117739643441 1.09223460309234 0.470588235294118 1.1 1 1 abnormal spleen red pulp morphology 0.0276427046281272 0.124117739643441 1.09223460309234 0.470588235294118 1.1 1 1 increased aggression towards mice 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 hyperlipidemia 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 nephrocalcinosis 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 abnormal duodenum morphology 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 decreased growth hormone level 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 increased circulating magnesium level 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 delayed heart development 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 abnormal ductus venosus valve morphology 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 abnormal cell cytoskeleton morphology 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 decreased startle reflex 8.70147030094194e-05 0.00147298451912628 1.09106768578134 0.47008547008547 1.1 1 1 decreased double-positive T cell number 0.000275472216231724 0.00368608986724681 1.09086930983847 0.47 1.1 1 1 postnatal lethality 3.41033165036486e-06 9.9802352709207e-05 1.09058967146117 0.469879518072289 1.1 1 1 absent kidney 0.00960522409620308 0.0590664486148222 1.08944829032935 0.469387755102041 1.1 1 1 abnormal epidermis stratum corneum morphology 0.00960522409620308 0.0590664486148222 1.08944829032935 0.469387755102041 1.1 1 1 increased T cell derived lymphoma incidence 0.00960522409620308 0.0590664486148222 1.08944829032935 0.469387755102041 1.1 1 1 abnormal lens morphology 4.7330502677869e-05 0.000881907306450931 1.08796806167401 0.46875 1.1 1 1 abnormal urine homeostasis 0.00039548692733168 0.00497079883754171 1.08796806167401 0.46875 1.1 1 1 abnormal vertebral body morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 abnormal crypts of Lieberkuhn morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 abnormal lymphatic vessel morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 abnormal lumbar vertebrae morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 decreased susceptibility to parasitic infection 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 bradykinesia 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 altered response to myocardial infarction 0.0140687564113742 0.0756670952936074 1.08313264806657 0.466666666666667 1.1 1 1 abnormal autopod morphology 0.0140687564113742 0.0756670952936074 1.08313264806657 0.466666666666667 1.1 1 1 abnormal microglial cell physiology 0.041198865434665 0.162541122551513 1.08313264806657 0.466666666666667 1.1 1 1 liver hemorrhage 0.041198865434665 0.162541122551513 1.08313264806657 0.466666666666667 1.1 1 1 abnormal fontanelle morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal prostate gland morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 audiogenic seizures 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 absent egg cylinders 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal cricoid cartilage morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal bronchus morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 increased alcohol consumption 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal energy homeostasis 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 absent chorion 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal secondary palate development 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 bicuspid aortic valve 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 herniated liver 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal suckling behavior 0.000816024832562832 0.00882548596086975 1.08137431584568 0.465909090909091 1.1 1 1 increased liver weight 0.000816024832562832 0.00882548596086975 1.08137431584568 0.465909090909091 1.1 1 1 decreased percent body fat/body weight 0.00220267424176837 0.0199604815169356 1.0810130147044 0.465753424657534 1.1 1 1 thrombocytosis 0.00604627915480525 0.0428493430130429 1.08046483366246 0.46551724137931 1.1 1 1 abnormal T cell differentiation 0.000366019247349456 0.00464526978460088 1.08006862360245 0.465346534653465 1.1 1 1 no abnormal phenotype detected 2.31460217048411e-49 5.75757289907923e-46 1.0795653112265 0.465129682997118 1.1 1 1 abnormal homeostasis 0.0170436285482207 0.0888805576807106 1.0795342007308 0.465116279069767 1.1 1 1 abnormal skeletal muscle fiber morphology 0.00264649214497638 0.0226614430658477 1.07877396537817 0.464788732394366 1.1 1 1 rib bifurcation 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 absent corpus callosum 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 enhanced coordination 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 corneal vascularization 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 abnormal renal tubule epithelium morphology 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 abnormal behavior 7.14618322294479e-09 4.09736526653965e-07 1.0770101099737 0.464028776978417 1.1 1 1 embryonic lethality before implantation, complete penetrance 8.94232218943665e-05 0.00150478353772547 1.07694331864905 0.464 1.1 1 1 abnormal food intake 0.00318035195490565 0.0260642216857022 1.076405116091 0.463768115942029 1.1 1 1 decreased body length 1.01207010072202e-08 5.59449861232451e-07 1.07579129018082 0.463503649635036 1.1 1 1 abnormal excitatory postsynaptic potential 0.00140627911298146 0.0140769388070076 1.07558468536227 0.463414634146341 1.1 1 1 arrested B cell differentiation 0.0206627120375359 0.104468488197908 1.07558468536227 0.463414634146341 1.1 1 1 abnormal cholesterol homeostasis 0.0206627120375359 0.104468488197908 1.07558468536227 0.463414634146341 1.1 1 1 decreased birth weight 0.000627762040760611 0.00721273938287308 1.07498879356983 0.463157894736842 1.1 1 1 abnormal mandible morphology 0.00879077047440703 0.0549423154650439 1.0745363572089 0.462962962962963 1.1 1 1 decreased compact bone thickness 0.00382267487062324 0.02983198232415 1.07389484296579 0.462686567164179 1.1 1 1 insulin resistance 6.91082908989934e-05 0.00123674009792263 1.07258265474124 0.462121212121212 1.1 1 1 abnormal lipid homeostasis 8.24714303244024e-05 0.00143963286268036 1.07123009149441 0.461538461538462 1.1 1 1 absent corpus luteum 0.0106059920993027 0.0633016694180401 1.07123009149441 0.461538461538462 1.1 1 1 abnormal skin condition 0.0106059920993027 0.0633016694180401 1.07123009149441 0.461538461538462 1.1 1 1 abnormal leukocyte adhesion 0.025070208275785 0.121445264042873 1.07123009149441 0.461538461538462 1.1 1 1 failure of heart looping 0.025070208275785 0.121445264042873 1.07123009149441 0.461538461538462 1.1 1 1 abnormal circulating hormone level 0.025070208275785 0.121445264042873 1.07123009149441 0.461538461538462 1.1 1 1 increased susceptibility to otitis media 0.0618058799101924 0.2190058778869 1.07123009149441 0.461538461538462 1.1 1 1 decreased circulating glycerol level 0.0618058799101924 0.2190058778869 1.07123009149441 0.461538461538462 1.1 1 1 short hair 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal sympathetic ganglion morphology 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 pup cannibalization 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal otolith morphology 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 anal atresia 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal insulin secretion 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 increased circulating ammonia level 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 orthokeratosis 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal aorta tunica media morphology 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 decreased cardiac stroke volume 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal cytokine secretion 2.0401669119356e-05 0.000445167999424544 1.07007075156855 0.461038961038961 1.1 1 1 gliosis 0.00552622498848109 0.0393882081915379 1.06839614945342 0.46031746031746 1.1 1 1 abnormal hindlimb morphology 0.0128014431561703 0.0694516681591573 1.06765932452276 0.46 1.1 1 1 increased body length 0.0128014431561703 0.0694516681591573 1.06765932452276 0.46 1.1 1 1 testicular atrophy 0.0128014431561703 0.0694516681591573 1.06765932452276 0.46 1.1 1 1 abnormal T cell activation 0.00290985461156885 0.0243314826709083 1.06640473072191 0.459459459459459 1.1 1 1 abnormal long bone metaphysis morphology 0.0304441299633269 0.132072929200835 1.06640473072191 0.459459459459459 1.1 1 1 decreased circulating chloride level 0.0304441299633269 0.132072929200835 1.06640473072191 0.459459459459459 1.1 1 1 abnormal hair follicle development 0.0304441299633269 0.132072929200835 1.06640473072191 0.459459459459459 1.1 1 1 cochlear outer hair cell degeneration 0.00349094081469535 0.0281481856614414 1.06379099363681 0.458333333333333 1.1 1 1 abnormal intestinal epithelium morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal cardiovascular system morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 small heart 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal lymph node morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal phalanx morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal malleus morphology 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal foregut morphology 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal body weight 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 curly vibrissae 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 apnea 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 hypopigmentation 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 increased body temperature 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal truncus arteriosus septation 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal colon morphology 0.00799619359959263 0.0522797245773669 1.06215187038005 0.457627118644068 1.1 1 1 abnormal humoral immune response 0.000527950281778227 0.00620934433060681 1.06102790014684 0.457142857142857 1.1 1 1 thick epidermis 0.00418855093644999 0.0319112418205799 1.06102790014684 0.457142857142857 1.1 1 1 increased carcinoma incidence 0.0370047574939738 0.150776960305094 1.06102790014684 0.457142857142857 1.1 1 1 decreased grip strength 8.35232502221785e-07 2.84608335517355e-05 1.05981668108275 0.45662100456621 1.1 1 1 seizures 0.000338743210640292 0.00436592609568771 1.05870108457635 0.456140350877193 1.1 1 1 incomplete embryo turning 0.00962205167958597 0.0590664486148222 1.05870108457635 0.456140350877193 1.1 1 1 decreased brain weight 0.00962205167958597 0.0590664486148222 1.05870108457635 0.456140350877193 1.1 1 1 abnormal circulating amino acid level 0.00962205167958597 0.0590664486148222 1.05870108457635 0.456140350877193 1.1 1 1 abnormal embryonic tissue morphology 5.35159674628706e-05 0.000978830654881549 1.05787007901545 0.45578231292517 1.1 1 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000481992664642395 0.00572294392982318 1.05499933253237 0.454545454545455 1.1 1 1 decreased circulating calcium level 0.0115814210226658 0.0644491829840741 1.05499933253237 0.454545454545455 1.1 1 1 abnormal photoreceptor outer segment morphology 0.0225732641435659 0.110533453852599 1.05499933253237 0.454545454545455 1.1 1 1 cochlear hair cell degeneration 0.0225732641435659 0.110533453852599 1.05499933253237 0.454545454545455 1.1 1 1 abnormal enterocyte morphology 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 increased body size 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 abnormal germ layer development 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 testis hypoplasia 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 abnormal tracheal cartilage morphology 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 decreased cardiac output 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 pulmonary vascular congestion 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 increased mammary gland tumor incidence 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 abnormal ear position 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal awl hair morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 enlarged cranium 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal stomach epithelium morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 delayed hepatic development 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal enteric ganglia morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal glossopharyngeal ganglion morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal eye distance/ position 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal food preference 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal hemoglobin 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 focal hepatic necrosis 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 vasculitis 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 secondary sex reversal 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal fear/anxiety-related behavior 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal primary sex determination 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal larynx morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 decreased post-tetanic potentiation 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 variable body spotting 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 patent ductus arteriosus 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 fused joints 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal frequency of paradoxical sleep 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 impaired luteinization 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal radial glial cell morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal lymph circulation 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal pituitary gland development 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 pharyngeal arch hypoplasia 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal dorsal-ventral polarity of the somites 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal Bruch membrane morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal platelet aggregation 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 aberrant origin of the right subclavian artery 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 shortened PR interval 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal extraembryonic ectoderm morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal dendritic cell chemotaxis 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal brain ependyma motile cilium morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal phrenic nerve innervation pattern to diaphragm 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 chylous ascites 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal tooth development 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 dextrocardia 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 decreased systemic arterial blood pressure 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 single kidney 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 abnormal middle ear ossicle morphology 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 abnormal osteoclast physiology 0.00723991111226586 0.0490716046097039 1.05170245961821 0.453125 1.1 1 1 decreased exploration in new environment 0.00240746759906915 0.0216194066883918 1.04997552618698 0.452380952380952 1.1 1 1 abnormal spleen white pulp morphology 0.027299337596323 0.122797653292683 1.04997552618698 0.452380952380952 1.1 1 1 abnormal cytotoxic T cell physiology 0.027299337596323 0.122797653292683 1.04997552618698 0.452380952380952 1.1 1 1 hydroencephaly 0.000438953693705161 0.00539208549674858 1.04949498818872 0.452173913043478 1.1 1 1 astrocytosis 0.00455376073736012 0.0333651836058418 1.04921851427192 0.452054794520548 1.1 1 1 autoimmune response 0.0548461763720094 0.203474815399513 1.04819288522571 0.451612903225806 1.1 1 1 abnormal T cell proliferation 0.0548461763720094 0.203474815399513 1.04819288522571 0.451612903225806 1.1 1 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0548461763720094 0.203474815399513 1.04819288522571 0.451612903225806 1.1 1 1 abnormal social investigation 0.00344074087483204 0.0277884510589114 1.04444933920705 0.45 1.1 1 1 epidermal hyperplasia 0.0104336071572074 0.0626898497670374 1.04444933920705 0.45 1.1 1 1 abnormal pericardium morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 increased urine glucose level 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal hair texture 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal trachea morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal heart right ventricle morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal optic stalk morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal renal glomerulus morphology 0.000742044615090896 0.00816741584087878 1.04338466098156 0.44954128440367 1.1 1 1 hyperkeratosis 0.00653194037990401 0.04500886896125 1.04276745621316 0.449275362318841 1.1 1 1 increased sarcoma incidence 0.0202274080122622 0.102580382121309 1.04208097335851 0.448979591836735 1.1 1 1 increased embryonic tissue cell apoptosis 0.00411313896393493 0.0314329744171679 1.04147370006401 0.448717948717949 1.1 1 1 decreased retinal photoreceptor cell number 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 aphagia 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 decreased bone strength 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 rib fusion 0.00782328382743292 0.0521028608319663 1.03925307383786 0.447761194029851 1.1 1 1 spleen hypoplasia 0.00105241271865149 0.0110692458251399 1.03892315222712 0.447619047619048 1.1 1 1 abnormal axial skeleton morphology 0.00491670004206004 0.0358659570516843 1.03834144833449 0.447368421052632 1.1 1 1 increased systemic arterial blood pressure 0.0243730402949093 0.11876187606971 1.03704189708501 0.446808510638298 1.1 1 1 abnormal craniofacial morphology 0.00125307793818241 0.0128537376133145 1.03656245099297 0.446601941747573 1.1 1 1 increased body weight 2.91725389081521e-06 8.63889173024146e-05 1.03616005873715 0.446428571428571 1.1 1 1 abnormal eye development 0.0150429457286459 0.0801270396145751 1.03616005873715 0.446428571428571 1.1 1 1 abnormal enzyme/coenzyme activity 8.70321073558392e-05 0.00147298451912628 1.03484010961774 0.445859872611465 1.1 1 1 increased circulating aspartate transaminase level 0.0112224187489087 0.0638804728556299 1.03155490292054 0.444444444444444 1.1 1 1 albuminuria 0.0293768703293194 0.128766458051422 1.03155490292054 0.444444444444444 1.1 1 1 lethality at weaning, complete penetrance 0.0293768703293194 0.128766458051422 1.03155490292054 0.444444444444444 1.1 1 1 abnormal palate morphology 0.0816941071781977 0.256862964844569 1.03155490292054 0.444444444444444 1.1 1 1 abnormal bone trabecula morphology 0.0816941071781977 0.256862964844569 1.03155490292054 0.444444444444444 1.1 1 1 abnormal heart left ventricle morphology 0.00702414124895317 0.0477392113572978 1.03155490292054 0.444444444444444 1.1 1 1 abnormal megakaryocyte differentiation 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal stomach glandular epithelium morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal radius morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal phrenic nerve morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 blepharoptosis 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 eye inflammation 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal thymus medulla morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 increased circulating glycerol level 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 absent inner cell mass 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 jerky movement 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal glycogen homeostasis 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 decreased lactate dehydrogenase level 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 decreased pulmonary respiratory rate 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 small thoracic cage 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal aerobic respiration 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal skeleton morphology 0.000857866899156801 0.009257891156844 1.02931239226202 0.443478260869565 1.1 1 1 decreased IgM level 0.00211328789450721 0.0193264839617158 1.02889625626353 0.443298969072165 1.1 1 1 increased circulating cholesterol level 4.59479867078668e-05 0.000866098936993236 1.02862434921906 0.443181818181818 1.1 1 1 short femur 0.00333242613910012 0.0269758606548673 1.02862434921906 0.443181818181818 1.1 1 1 hunched posture 0.00527598930030355 0.0381512307689101 1.02829048867079 0.443037974683544 1.1 1 1 cachexia 0.0015984146867628 0.015778002116359 1.02659550434881 0.442307692307692 1.1 1 1 decreased body temperature 0.0216975988925327 0.108209565713272 1.02659550434881 0.442307692307692 1.1 1 1 abnormal blood circulation 0.0354184405927376 0.144787791248044 1.02555749069426 0.441860465116279 1.1 1 1 obese 0.00629385345388251 0.0434284617656941 1.02485649446002 0.441558441558442 1.1 1 1 abnormal nervous system development 0.0587485841990627 0.210817112428594 1.02396994039907 0.441176470588235 1.1 1 1 abnormal direction of heart looping 0.0587485841990627 0.210817112428594 1.02396994039907 0.441176470588235 1.1 1 1 decreased osteoblast cell number 0.0587485841990627 0.210817112428594 1.02396994039907 0.441176470588235 1.1 1 1 syndactyly 0.0160973821488738 0.0841223489397551 1.02281291221783 0.440677966101695 1.1 1 1 increased hemoglobin content 0.0160973821488738 0.0841223489397551 1.02281291221783 0.440677966101695 1.1 1 1 abnormal inner ear vestibule morphology 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 abnormal feces composition 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 increased liver glycogen level 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 increased thermal nociceptive threshold 0.00355825223127394 0.0285521045977223 1.02021913475658 0.43956043956044 1.1 1 1 increased tumor growth/size 0.0427151572477337 0.168389783920345 1.01897496508005 0.439024390243902 1.1 1 1 decreased rib number 0.00423133618446265 0.0321879166937335 1.01706677226155 0.438202247191011 1.1 1 1 abnormal neuron differentiation 0.00152950729803448 0.0151882211730968 1.01543685756241 0.4375 1.1 1 1 retinal degeneration 0.00318533603716722 0.0260642216857022 1.01543685756241 0.4375 1.1 1 1 oligodactyly 0.0313067550251157 0.13244141687921 1.01543685756241 0.4375 1.1 1 1 scoliosis 0.0712758141086685 0.238841492273665 1.01543685756241 0.4375 1.1 1 1 pancreatic islet hyperplasia 0.0712758141086685 0.238841492273665 1.01543685756241 0.4375 1.1 1 1 abnormal intestinal absorption 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal meiosis 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 paternal imprinting 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 decreased cochlear coiling 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 impaired muscle relaxation 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal level of surface class II molecules 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal Langerhans cell physiology 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 impaired somite development 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 decreased liver cholesterol level 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal thoracic cage shape 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal urinary bladder physiology 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 dilated respiratory conducting tubes 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 decreased fibroblast apoptosis 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 increased circulating calcium level 0.0230855305572394 0.112709042710762 1.01279935923108 0.436363636363636 1.1 1 1 acanthosis 0.0515302387586581 0.192032163164288 1.01171730863361 0.435897435897436 1.1 1 1 increased hepatocyte apoptosis 0.0515302387586581 0.192032163164288 1.01171730863361 0.435897435897436 1.1 1 1 abnormal response to injury 0.0515302387586581 0.192032163164288 1.01171730863361 0.435897435897436 1.1 1 1 circling 0.00597909277986453 0.0424336470468274 1.01031700786041 0.435294117647059 1.1 1 1 abnormal coat appearance 0.012723546784124 0.0692556293774802 1.00912979633531 0.434782608695652 1.1 1 1 abnormal immune system morphology 0.0376088218225887 0.153112838434844 1.00912979633531 0.434782608695652 1.1 1 1 abnormal blood vessel physiology 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 abnormal innervation pattern to muscle 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 conjunctivitis 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 abnormal cochlear ganglion morphology 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 increased neutrophil cell number 0.00045148299118692 0.00550521539498757 1.00843384475163 0.43448275862069 1.1 1 1 abnormal long bone epiphyseal plate morphology 0.0204285042013246 0.103494713239908 1.00576603034753 0.433333333333333 1.1 1 1 delayed eyelid opening 0.0865391866374049 0.256862964844569 1.00576603034753 0.433333333333333 1.1 1 1 salivary gland inflammation 0.0865391866374049 0.256862964844569 1.00576603034753 0.433333333333333 1.1 1 1 abnormal pain threshold 0.0865391866374049 0.256862964844569 1.00576603034753 0.433333333333333 1.1 1 1 increased circulating phosphate level 0.062182248784944 0.220026093673611 1.00367504067945 0.432432432432432 1.1 1 1 decreased width of hypertrophic chondrocyte zone 0.062182248784944 0.220026093673611 1.00367504067945 0.432432432432432 1.1 1 1 decreased sensitivity to induced morbidity/mortality 0.0451807746941081 0.177127150593528 1.00224936590575 0.431818181818182 1.1 1 1 increased kidney weight 0.0330948110137182 0.137190295920277 1.00121505283464 0.431372549019608 1.1 1 1 cochlear inner hair cell degeneration 0.0330948110137182 0.137190295920277 1.00121505283464 0.431372549019608 1.1 1 1 failure of chorioallantoic fusion 0.0330948110137182 0.137190295920277 1.00121505283464 0.431372549019608 1.1 1 1 abnormal vertebrae morphology 0.00268780045801758 0.0229756138808204 1.0007975319619 0.431192660550459 1.1 1 1 abnormal visceral yolk sac morphology 0.010021188753758 0.0605041432644979 0.998910760423056 0.430379746835443 1.1 1 1 abnormal eye electrophysiology 0.00180812375652931 0.0169405191878217 0.997453914394243 0.429752066115702 1.1 1 1 abnormal seminal vesicle morphology 0.0291174691786845 0.128432047530706 0.994713656387665 0.428571428571429 1.1 1 1 abnormal pancreas morphology 0.054277021986292 0.201814786533485 0.994713656387665 0.428571428571429 1.1 1 1 increased circulating serum albumin level 0.0750564542278792 0.249667084915636 0.994713656387665 0.428571428571429 1.1 1 1 abnormal hippocampus pyramidal cell morphology 0.0750564542278792 0.249667084915636 0.994713656387665 0.428571428571429 1.1 1 1 abnormal jaw morphology 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 reddish skin 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 abnormal respiration 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 straub tail 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 failure of blastocyst to hatch from the zona pellucida 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 increased incidence of induced tumors 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 abnormal embryonic/fetal subventricular zone morphology 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 increased keratinocyte proliferation 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 complete atrioventricular septal defect 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 midline facial cleft 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal placing response 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 absent otoliths 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal prepulse inhibition 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal imprinting 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal decidualization 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 skeletal muscle necrosis 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal iris pigmentation 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal renal reabsorbtion 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal response/metabolism to endogenous compounds 0.0105307548521775 0.0631972320742857 0.990670104938935 0.426829268292683 1.1 1 1 abnormal inhibitory postsynaptic currents 0.0189791629148699 0.0966441509738769 0.989837609052431 0.426470588235294 1.1 1 1 abnormal male meiosis 0.0256193169274443 0.122355018309237 0.989278062636913 0.426229508196721 1.1 1 1 polyphagia 0.0347479098447933 0.142163529175861 0.988573448632186 0.425925925925926 1.1 1 1 abnormal tibia morphology 0.0474131044356846 0.183412212087438 0.987658949604774 0.425531914893617 1.1 1 1 abnormal T-helper 1 physiology 0.0474131044356846 0.183412212087438 0.987658949604774 0.425531914893617 1.1 1 1 short limbs 0.00932100360142164 0.0578926253646351 0.987091329518794 0.425287356321839 1.1 1 1 perinatal lethality 0.0652016704102324 0.22779375722676 0.986424375917768 0.425 1.1 1 1 abnormal pancreatic beta cell morphology 0.0652016704102324 0.22779375722676 0.986424375917768 0.425 1.1 1 1 increased susceptibility to weight loss 0.0652016704102324 0.22779375722676 0.986424375917768 0.425 1.1 1 1 diarrhea 0.0906182230047504 0.256862964844569 0.984666043696881 0.424242424242424 1.1 1 1 abnormal gait 2.90190497658594e-06 8.63889173024146e-05 0.983983196232458 0.423948220064725 1.1 1 1 abnormal stomach morphology 0.127875179001808 0.331515901789472 0.981960917203208 0.423076923076923 1.1 1 1 heart inflammation 0.127875179001808 0.331515901789472 0.981960917203208 0.423076923076923 1.1 1 1 abnormal tectorial membrane morphology 0.127875179001808 0.331515901789472 0.981960917203208 0.423076923076923 1.1 1 1 abnormal rib morphology 0.00185087033517798 0.0171153901812462 0.979977157774515 0.422222222222222 1.1 1 1 decreased eosinophil cell number 0.0267695063875468 0.122797653292683 0.979171255506608 0.421875 1.1 1 1 abnormal frontal bone morphology 0.0783174265795173 0.256862964844569 0.977262539608934 0.421052631578947 1.1 1 1 decreased neuron apoptosis 0.0783174265795173 0.256862964844569 0.977262539608934 0.421052631578947 1.1 1 1 shiny skin 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal long term depression 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal neurotransmitter level 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal response to novelty 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal digestive system development 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 maternal imprinting 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal sternebra morphology 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal cochlear inner hair cell morphology 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal behavioral response to xenobiotic 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 thin interventricular septum 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal epidermal layer morphology 0.0235144846096607 0.114690746012806 0.975492136457469 0.420289855072464 1.1 1 1 abnormal axon extension 0.0494313543398199 0.186445024898108 0.974819383259912 0.42 1.1 1 1 abnormal skeleton development 0.0153918949724692 0.0817267422537152 0.974246297202734 0.419753086419753 1.1 1 1 abnormal retinal photoreceptor layer morphology 0.109428582940191 0.296356668550598 0.973321964852447 0.419354838709677 1.1 1 1 inner cell mass degeneration 0.109428582940191 0.296356668550598 0.973321964852447 0.419354838709677 1.1 1 1 decreased double-negative T cell number 0.109428582940191 0.296356668550598 0.973321964852447 0.419354838709677 1.1 1 1 abnormal left-right axis patterning 0.0678552005896511 0.236069666387073 0.971580780657719 0.418604651162791 1.1 1 1 abnormal T-helper 2 physiology 0.0431302449577226 0.169891503297442 0.970599385929782 0.418181818181818 1.1 1 1 abnormal locomotor activation 0.0119540084152367 0.0658708598868335 0.969208178018751 0.417582417582418 1.1 1 1 increased food intake 0.0159878682946177 0.0837259418586559 0.967082721488008 0.416666666666667 1.1 1 1 abnormal pharyngeal arch morphology 0.0940555952034483 0.264964091810394 0.967082721488008 0.416666666666667 1.1 1 1 head tilt 0.0940555952034483 0.264964091810394 0.967082721488008 0.416666666666667 1.1 1 1 abnormal vasodilation 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 decreased ovulation rate 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 decreased fatty acid level 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 increased circulating total protein level 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 abnormal cellular extravasation 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 abnormal inner cell mass apoptosis 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 absent optic nerve 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal pilomotor reflex 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 ear inflammation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal tracheal ciliated epithelium morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 increased circulating parathyroid hormone level 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 small thyroid gland 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 impaired sperm capacitation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 delayed somite formation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal anogenital distance 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal amacrine cell morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal palatine bone morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal fatty acid level 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal patella morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal thymus corticomedullary boundary morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 hydrometra 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 reduced cerebellar foliation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal behavioral response to addictive substance 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 impaired behavioral response to cocaine 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 decreased oligodendrocyte number 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal aorta elastic tissue morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 decreased mammary gland epithelial cell proliferation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal colon goblet cell morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal vitelline vein connection 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 scaly skin 0.081129617233669 0.256862964844569 0.962365244797822 0.414634146341463 1.1 1 1 abnormal circulating glucose level 0.132161838697777 0.342272330828443 0.960413185477746 0.413793103448276 1.1 1 1 stomach inflammation 0.132161838697777 0.342272330828443 0.960413185477746 0.413793103448276 1.1 1 1 abnormal limb morphology 0.025282171656278 0.122352922169244 0.959346059716104 0.413333333333333 1.1 1 1 abnormal lymphocyte physiology 0.0701852720350704 0.238841492273665 0.958673306518547 0.41304347826087 1.1 1 1 increased circulating insulin level 0.00175255973321115 0.0164509144768405 0.957411894273128 0.4125 1.1 1 1 abnormal trabecular bone morphology 0.00660380062844487 0.045263559129701 0.955705277705796 0.411764705882353 1.1 1 1 abnormal response to novel object 0.0608669346680908 0.215986447912804 0.955705277705796 0.411764705882353 1.1 1 1 abnormal vision 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 increased width of hypertrophic chondrocyte zone 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 abnormal skin physiology 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 increased susceptibility to viral infection induced morbidity/mortality 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 abnormal adipose tissue morphology 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 abnormal urinary bladder morphology 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 increased incidence of corneal inflammation 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 abnormal dorsal-ventral axis patterning 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 abnormal melanosome morphology 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 pancytopenia 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 increased brain size 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 enhanced behavioral response to cocaine 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 common atrium 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 short mandible 0.0528967250461431 0.196829623862799 0.953267254038179 0.410714285714286 1.1 1 1 small lens 0.0969519920201148 0.270823223076963 0.952204525772808 0.41025641025641 1.1 1 1 abnormal NK cell physiology 0.046053635238337 0.17969947867508 0.951228906381647 0.409836065573771 1.1 1 1 increased circulating HDL cholesterol level 0.0116306713042015 0.0646509382551984 0.950504160548213 0.40952380952381 1.1 1 1 abnormal abdominal fat pad morphology 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 intestinal ulcer 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 intracerebral hemorrhage 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal channel response 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal retinal outer plexiform layer morphology 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal limb posture 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal temporal bone morphology 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 decreased susceptibility to viral infection induced morbidity/mortality 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 impaired swimming 0.0401593642526866 0.159578943416227 0.949499399279135 0.409090909090909 1.1 1 1 abnormal respiratory system physiology 0.0722289324490808 0.241491222402001 0.947346339416824 0.408163265306122 1.1 1 1 abnormal craniofacial development 0.0722289324490808 0.241491222402001 0.947346339416824 0.408163265306122 1.1 1 1 abnormal brain commissure morphology 0.15962466588054 0.393934062966776 0.94559199434383 0.407407407407407 1.1 1 1 abnormal skin appearance 0.15962466588054 0.393934062966776 0.94559199434383 0.407407407407407 1.1 1 1 decreased bone ossification 0.15962466588054 0.393934062966776 0.94559199434383 0.407407407407407 1.1 1 1 neonatal lethality 0.135533108982811 0.348463678134101 0.942905653450808 0.40625 1.1 1 1 abnormal long term potentiation 0.135533108982811 0.348463678134101 0.942905653450808 0.40625 1.1 1 1 increased white adipose tissue amount 0.115787422306974 0.311374284311998 0.940945350636981 0.405405405405405 1.1 1 1 abnormal branching of the mammary ductal tree 0.115787422306974 0.311374284311998 0.940945350636981 0.405405405405405 1.1 1 1 abnormal vocalization 0.115787422306974 0.311374284311998 0.940945350636981 0.405405405405405 1.1 1 1 kinked neural tube 0.0740184678963351 0.2473081784985 0.937326330057607 0.403846153846154 1.1 1 1 impaired natural killer cell mediated cytotoxicity 0.0641418933328068 0.224564334504373 0.936543267125229 0.403508771929825 1.1 1 1 abnormal femur morphology 0.0484711636786162 0.184501942847066 0.935327766454073 0.402985074626866 1.1 1 1 abnormal motor capabilities/coordination/movement 0.00879032196039139 0.0549423154650439 0.931916077070262 0.401515151515151 1.1 1 1 abnormal joint morphology 0.0755820171655824 0.249667084915636 0.928399412628488 0.4 1.1 1 1 abnormal rostral-caudal axis patterning 0.0755820171655824 0.249667084915636 0.928399412628488 0.4 1.1 1 1 abnormal thyroid gland morphology 0.192775136411239 0.446394331896176 0.928399412628488 0.4 1.1 1 1 increased cellular sensitivity to ionizing radiation 0.192775136411239 0.446394331896176 0.928399412628488 0.4 1.1 1 1 abnormal posture 0.0376710089235308 0.153240612751076 0.928399412628487 0.4 1.1 1 1 abnormal incisor morphology 0.0655075417459176 0.228701768551537 0.928399412628487 0.4 1.1 1 1 impaired behavioral response to xenobiotic 0.138173980795967 0.355070017799553 0.928399412628487 0.4 1.1 1 1 abnormal heart tube morphology 0.162576940071358 0.393934062966776 0.928399412628487 0.4 1.1 1 1 gastrointestinal hemorrhage 0.162576940071358 0.393934062966776 0.928399412628487 0.4 1.1 1 1 brain inflammation 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal dopamine level 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal lens epithelium morphology 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal male reproductive system physiology 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 dilated vasculature 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 kidney atrophy 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal induced retinal neovascularization 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 enhanced behavioral response to xenobiotic 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal circulating cytokine level 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 decreased muscle cell glucose uptake 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 interdigital webbing 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal apical ectodermal ridge morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal respiratory system morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 arthritis 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 dilated ureter 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal rostral migratory stream morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal trophectoderm morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal zygomatic bone morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 decreased trabecular bone mass 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 decreased brown adipose tissue mass 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 polydactyly 0.025733908897738 0.122355018309237 0.923662680931403 0.397959183673469 1.1 1 1 abnormal coat/ hair morphology 0.088957894447464 0.256862964844569 0.91964092760369 0.39622641509434 1.1 1 1 abnormal male reproductive system morphology 0.120007885232961 0.32030001557617 0.917604070621179 0.395348837209302 1.1 1 1 hyporesponsive to tactile stimuli 0.140224376042272 0.360152953438463 0.916183630883376 0.394736842105263 1.1 1 1 abnormal neuron morphology 0.0303976559410003 0.132072929200835 0.914332754861389 0.393939393939394 1.1 1 1 abnormal aorta morphology 0.164727784868551 0.394000350827424 0.914332754861389 0.393939393939394 1.1 1 1 absent vibrissae 0.164727784868551 0.394000350827424 0.914332754861389 0.393939393939394 1.1 1 1 decreased inflammatory response 0.0454343246493655 0.177422107637828 0.911820851688693 0.392857142857143 1.1 1 1 increased circulating luteinizing hormone level 0.194870707089602 0.446394331896176 0.911820851688693 0.392857142857143 1.1 1 1 abnormal spleen germinal center morphology 0.194870707089602 0.446394331896176 0.911820851688693 0.392857142857143 1.1 1 1 decreased food intake 0.052072953668438 0.193909389596167 0.910771575679845 0.392405063291139 1.1 1 1 impaired hematopoiesis 0.104563048943747 0.28598195079447 0.910195502576949 0.392156862745098 1.1 1 1 fragile skeleton 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 blistering 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 hypotension 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 failure of embryo implantation 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 pancreas inflammation 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal crista ampullaris morphology 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal ulna morphology 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal palatal shelf fusion at midline 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal hepatocyte physiology 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal tooth morphology 0.0791473037466872 0.256862964844569 0.906640051395007 0.390625 1.1 1 1 abnormal cochlea morphology 0.105730267461572 0.288223605819901 0.902610540055474 0.388888888888889 1.1 1 1 abnormal systemic arterial blood pressure 0.166249317082115 0.397257614065092 0.902610540055474 0.388888888888889 1.1 1 1 narrow eye opening 0.166249317082115 0.397257614065092 0.902610540055474 0.388888888888889 1.1 1 1 abnormal mammary gland morphology 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 thick dermal layer 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 abnormal iron level 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 abnormal redox activity 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 decreased heart rate variability 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 abnormal sperm axoneme morphology 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 decreased tumor latency 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 decreased fluid intake 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 increased circulating LDL cholesterol level 0.122723764308059 0.326672406330975 0.899979022445983 0.387755102040816 1.1 1 1 increased lung adenoma incidence 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 abnormal nose morphology 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 decreased neuronal precursor cell number 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 hypertension 0.142961036640805 0.364014045894219 0.896749432652516 0.386363636363636 1.1 1 1 abnormal circadian rhythm 0.142961036640805 0.364014045894219 0.896749432652516 0.386363636363636 1.1 1 1 abnormal amino acid level 0.142961036640805 0.364014045894219 0.896749432652516 0.386363636363636 1.1 1 1 increased autoantibody level 0.16726961605612 0.398521558500081 0.892691742912007 0.384615384615385 1.1 1 1 eyelids open at birth 0.123653412098379 0.328970976037132 0.892691742912007 0.384615384615385 1.1 1 1 abnormal xiphoid process morphology 0.233337609792133 0.478702931429221 0.892691742912007 0.384615384615385 1.1 1 1 absent common myeloid progenitor cells 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 absent myocardial trabeculae 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 abnormal mast cell morphology 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 tight skin 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 lymphoid hypoplasia 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 absent lateral semicircular canal 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 tracheoesophageal fistula 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 decreased alcohol consumption 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 muscle fatigue 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 decreased endocochlear potential 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 small pituitary gland 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 increased circulating glucose level 0.02278144370233 0.111333676246652 0.888893054644296 0.382978723404255 1.1 1 1 short maxilla 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 decreased regulatory T cell number 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 decreased cytotoxic T cell cytolysis 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 increased susceptibility to weight gain 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 abnormal vibrissa morphology 0.167885913669237 0.398869350766215 0.884189916789036 0.380952380952381 1.1 1 1 abnormal tumor vascularization 0.280810562572851 0.496698746879043 0.884189916789036 0.380952380952381 1.1 1 1 increased bone ossification 0.280810562572851 0.496698746879043 0.884189916789036 0.380952380952381 1.1 1 1 increased susceptibility to induced arthritis 0.233192793329052 0.478603195879551 0.8803787533546 0.379310344827586 1.1 1 1 polychromatophilia 0.233192793329052 0.478603195879551 0.8803787533546 0.379310344827586 1.1 1 1 malocclusion 0.1969652530322 0.446628137573016 0.878215660594515 0.378378378378378 1.1 1 1 skin inflammation 0.1969652530322 0.446628137573016 0.878215660594515 0.378378378378378 1.1 1 1 abnormal humerus morphology 0.1969652530322 0.446628137573016 0.878215660594515 0.378378378378378 1.1 1 1 abnormal developmental patterning 0.0826916468188805 0.256862964844569 0.877450664374485 0.378048780487805 1.1 1 1 decreased body height 0.279000637340978 0.496698746879043 0.870374449339207 0.375 1.1 1 1 abnormal nursing 0.279000637340978 0.496698746879043 0.870374449339207 0.375 1.1 1 1 decreased aggression towards mice 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 abnormal molar crown morphology 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 increased thymus weight 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 abnormal intestinal lipid absorption 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 loose skin 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 decreased skeletal muscle weight 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 decreased adipocyte glucose uptake 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 abnormal intestinal mucosa morphology 0.19625807866851 0.446448990112409 0.86362736058464 0.372093023255814 1.1 1 1 decreased susceptibility to pharmacologically induced seizures 0.276698165034246 0.496698746879043 0.859629085767118 0.37037037037037 1.1 1 1 decreased threshold for auditory brainstem response 0.230064097942992 0.476308317630623 0.855104722157817 0.368421052631579 1.1 1 1 irregular coat pigmentation 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 abnormal ear morphology 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 abnormal nasal septum morphology 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 osteoarthritis 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 abnormal hair cycle 0.2740756557414 0.496698746879043 0.851032794909447 0.366666666666667 1.1 1 1 arrested T cell differentiation 0.2740756557414 0.496698746879043 0.851032794909447 0.366666666666667 1.1 1 1 abnormal cellular respiration 0.2740756557414 0.496698746879043 0.851032794909447 0.366666666666667 1.1 1 1 short ulna 0.228472407020418 0.473209918787085 0.849145804233373 0.365853658536585 1.1 1 1 abnormal basisphenoid bone morphology 0.332947082371852 0.545123720251024 0.843999466025898 0.363636363636364 1.1 1 1 abnormal skeleton physiology 0.271244347891053 0.496698746879043 0.843999466025898 0.363636363636364 1.1 1 1 abnormal innervation 0.224828129735995 0.467608672841378 0.839510107164058 0.361702127659574 1.1 1 1 short radius 0.268278491506395 0.496698746879043 0.83813835862294 0.361111111111111 1.1 1 1 abnormal stomach mucosa morphology 0.327502481613956 0.539690243799083 0.835559471365639 0.36 1.1 1 1 increased sacral vertebrae number 0.188153925851969 0.441748834881333 0.834108847283407 0.359375 1.1 1 1 abnormal action potential 0.185096782490625 0.434776436681236 0.828928046989721 0.357142857142857 1.1 1 1 abnormal somite shape 0.322157863892382 0.531058771658251 0.828928046989721 0.357142857142857 1.1 1 1 abnormal vasoconstriction 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 absent atrioventricular cushions 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal olfactory system physiology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal ventral body wall morphology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal vascular endothelial cell migration 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal sagittal suture morphology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal squamosal bone morphology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal positive T cell selection 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 increased B-1 B cell number 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 increased circulating growth hormone level 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 increased susceptibility to parasitic infection 0.155691876315492 0.388448889001793 0.825243922336433 0.355555555555556 1.1 1 1 abnormal cartilage development 0.25901158646038 0.496698746879043 0.825243922336433 0.355555555555556 1.1 1 1 abnormal hair shaft morphology 0.255887382377757 0.496698746879043 0.822020313264807 0.354166666666667 1.1 1 1 enlarged sebaceous gland 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 abnormal touch/ nociception 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 absence seizures 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 abnormal circulating chemokine level 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 abnormal survival 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 increased trabecular bone mass 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 decreased body fat mass 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 waved hair 0.396248417245365 0.606005495172361 0.812349486049927 0.35 1.1 1 1 nuclear cataracts 0.396248417245365 0.606005495172361 0.812349486049927 0.35 1.1 1 1 abnormal hair growth 0.284147036577324 0.496698746879043 0.803422568620806 0.346153846153846 1.1 1 1 abnormal nerve conduction 0.377354472578451 0.577642615716244 0.803422568620806 0.346153846153846 1.1 1 1 lordosis 0.368981585241504 0.564999503409197 0.800344321231455 0.344827586206897 1.1 1 1 absent long term depression 0.368981585241504 0.564999503409197 0.800344321231455 0.344827586206897 1.1 1 1 enlarged epididymis 0.368981585241504 0.564999503409197 0.800344321231455 0.344827586206897 1.1 1 1 increased dopamine level 0.36116146933637 0.553536139848565 0.797843245227607 0.34375 1.1 1 1 abnormal serotonin level 0.36116146933637 0.553536139848565 0.797843245227607 0.34375 1.1 1 1 short humerus 0.340272565731332 0.545123720251024 0.792536083951148 0.341463414634146 1.1 1 1 abnormal pancreatic islet morphology 0.316728054202122 0.522281097002174 0.788263652231735 0.339622641509434 1.1 1 1 trunk curl 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 increased vasoconstriction 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 decreased cochlear outer hair cell number 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 increased acute inflammation 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 abnormal clavicle morphology 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 abnormal reflex 0.396576620040386 0.606321046312514 0.773666177190406 0.333333333333333 1.1 1 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.406120030059028 0.620721090489606 0.773666177190406 0.333333333333333 1.1 1 1 abnormal estrous cycle 0.416434549991556 0.63492549378118 0.773666177190406 0.333333333333333 1.1 1 1 abnormal single cell response 0.427682626350554 0.649884259649971 0.773666177190406 0.333333333333333 1.1 1 1 abnormal digestive system morphology 0.440087393572384 0.665481696967359 0.773666177190406 0.333333333333333 1.1 1 1 abnormal osteoblast morphology 0.440087393572384 0.665481696967359 0.773666177190406 0.333333333333333 1.1 1 1 decreased chondrocyte number 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 cortical renal glomerulopathies 0.469799654368874 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 decreased salivation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 hyperpigmentation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 altered righting response 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 joint inflammation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 decreased aggression towards males 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 increased susceptibility to autoimmune disorder 0.469799654368874 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 abnormal microglial cell activation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 increased percent body fat/body weight 0.392362787605681 0.600432134216629 0.758787981475206 0.326923076923077 1.1 1 1 increased insulin secretion 0.439618279733412 0.665176685423882 0.752756280509584 0.324324324324324 1.1 1 1 abnormal respiratory electron transport chain 0.439618279733412 0.665176685423882 0.752756280509584 0.324324324324324 1.1 1 1 abnormal bone remodeling 0.451204210569491 0.674501486653611 0.750911289625983 0.323529411764706 1.1 1 1 abnormal eyelid morphology 0.463813912624806 0.684701499840551 0.748709203732651 0.32258064516129 1.1 1 1 abnormal stria vascularis morphology 0.47766804014653 0.684701499840551 0.746035242290749 0.321428571428571 1.1 1 1 parakeratosis 0.510443466946181 0.684701499840551 0.738499532772661 0.318181818181818 1.1 1 1 abnormal retinal layer morphology 0.510443466946181 0.684701499840551 0.738499532772661 0.318181818181818 1.1 1 1 increased susceptibility to ischemic brain injury 0.530427255396596 0.709375160107006 0.732946904706701 0.315789473684211 1.1 1 1 increased lung adenocarcinoma incidence 0.474483008154019 0.684701499840551 0.728156402061559 0.313725490196078 1.1 1 1 reduced male mating frequency 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 white spotting 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 increased pancreatic beta cell number 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 bowed tibia 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 abnormal wound healing 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 decreased circulating growth hormone level 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 decreased circulating prolactin level 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 abnormal fertilization 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 focal hair loss 0.526576944853791 0.704415246208016 0.720309889108309 0.310344827586207 1.1 1 1 abnormal lens fiber morphology 0.524536757832966 0.701874763372513 0.714153394329606 0.307692307692308 1.1 1 1 abnormal retinal cone cell morphology 0.564716067664297 0.748192393243642 0.706390857434719 0.304347826086957 1.1 1 1 abnormal sacral vertebrae morphology 0.564716067664297 0.748192393243642 0.706390857434719 0.304347826086957 1.1 1 1 abnormal regulatory T cell physiology 0.564716067664297 0.748192393243642 0.706390857434719 0.304347826086957 1.1 1 1 belly spot 0.555845455015428 0.737028555091086 0.703332888354915 0.303030303030303 1.1 1 1 hypoalgesia 0.641518522613324 0.820219167329452 0.663142437591777 0.285714285714286 1.1 1 1 decreased pancreatic beta cell number 0.737055464258765 0.909090564485234 0.61438196423944 0.264705882352941 1.1 1 1 eyelids fail to open 0.721388505187451 0.890990023164739 0.610789087255584 0.263157894736842 1.1 1 1 decreased liver glycogen level 0.721388505187451 0.890990023164739 0.610789087255584 0.263157894736842 1.1 1 1 cryptorchism 0.747777806861124 0.909090564485234 0.601740360036983 0.259259259259259 1.1 1 1 abnormal basioccipital bone morphology 0.76587384966756 0.914160845032656 0.580249632892805 0.25 1.1 1 1 abnormal eye physiology 0.903426612542897 1 0.541566324033284 0.233333333333333 1.1 1 1 abnormal body temperature homeostasis 0.939008159979998 1 0.449225522239591 0.193548387096774 1.1 1 1 abnormal blood pressure regulation 1.69325858886215e-05 0.000946512525796538 7.99602227525855 1 1.3 1 3 delayed limb development 9.21954565952468e-05 0.00375960980787994 6.66335189604879 0.833333333333333 1.3 1 3 abnormal vascular endothelial cell development 4.12486253157517e-07 4.18799818256867e-05 5.99701670644391 0.75 1.3 1 3 arteritis 0.000292914196869981 0.00971498752952105 5.71144448232754 0.714285714285714 1.3 1 3 abnormal artery development 0.000117077837610907 0.00448047878549431 5.33068151683903 0.666666666666667 1.3 1 3 abnormal umbilical artery morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 increased cardiac output 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 elevated level of mitotic sister chromatid exchange 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 abnormal olfactory bulb mitral cell layer morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 abnormal hepatic vein morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 abnormal bronchiole epithelium morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 increased atrioventricular cushion size 0.000265030465090148 0.00884917156928513 4.79761336515513 0.6 1.3 1 3 increased circulating fructosamine level 0.000265030465090148 0.00884917156928513 4.79761336515513 0.6 1.3 1 3 decreased circulating lactate level 0.000265030465090148 0.00884917156928513 4.79761336515513 0.6 1.3 1 3 abnormal germ cell morphology 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 increased neuronal precursor cell number 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 iris coloboma 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 abnormal ductus venosus valve topology 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 abnormal vascular regression 2.0300210076953e-06 0.000157802414270065 4.3978122513922 0.55 1.3 1 3 abnormal vascular branching morphogenesis 7.72724619441808e-07 7.11908329948703e-05 4.36146669559557 0.545454545454545 1.3 1 3 liver vascular congestion 7.22770464313085e-05 0.00309981298272207 4.26454521347123 0.533333333333333 1.3 1 3 abnormal lymphatic vessel morphology 5.48797482763577e-08 7.00068583781743e-06 3.99801113762928 0.5 1.3 1 3 dilated vasculature 1.82827326853535e-05 0.000999523023182785 3.99801113762928 0.5 1.3 1 3 fused cornea and lens 0.00263392253406075 0.0413367968673572 3.99801113762928 0.5 1.3 1 3 bifid ureter 0.00263392253406075 0.0413367968673572 3.99801113762928 0.5 1.3 1 3 abnormal developmental vascular remodeling 0.00263392253406075 0.0413367968673572 3.99801113762928 0.5 1.3 1 3 abnormal blood flow velocity 0.00035172606904176 0.0108934676806607 3.99801113762928 0.5 1.3 1 3 decreased circulating fructosamine level 1.7142710778945e-06 0.000139811452664346 3.84993665105041 0.481481481481481 1.3 1 3 delayed intramembranous bone ossification 0.000596243963825903 0.0158536812399085 3.73147706178732 0.466666666666667 1.3 1 3 abnormal pericyte morphology 0.000596243963825903 0.0158536812399085 3.73147706178732 0.466666666666667 1.3 1 3 absent hypoglossal nerve 0.00161017445638842 0.0297792487752134 3.6904718193501 0.461538461538462 1.3 1 3 enlarged pericardium 6.93030709454965e-07 6.63043803757395e-05 3.63455557966298 0.454545454545455 1.3 1 3 pulmonary vascular congestion 5.18570070809982e-05 0.00230346973417827 3.63455557966298 0.454545454545455 1.3 1 3 abnormal sebaceous gland morphology 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 palatal shelf hypoplasia 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 chylous ascites 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 thin hypoglossal nerve 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 abnormal capillary morphology 1.79963538511051e-06 0.000142114064141664 3.61110683398773 0.451612903225806 1.3 1 3 absent ductus venosus valve 0.000136668863877574 0.00511223757737541 3.59821002386635 0.45 1.3 1 3 abnormal mammary gland morphology 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 thick dermal layer 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 increased circulating renin level 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 abnormal pregnancy 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 liver hypoplasia 1.48617033901558e-09 3.08070726525105e-07 3.53670216021051 0.442307692307692 1.3 1 3 abnormal embryonic hematopoiesis 2.87157564083582e-06 0.000207999257953207 3.49825974542562 0.4375 1.3 1 3 vasculature congestion 0.000958536764078936 0.0219756700520401 3.49825974542562 0.4375 1.3 1 3 small pancreas 0.000958536764078936 0.0219756700520401 3.49825974542562 0.4375 1.3 1 3 abnormal artery morphology 1.74652574460757e-06 0.000140144606119721 3.42686668939652 0.428571428571429 1.3 1 3 abnormal fluid regulation 0.00255401074689843 0.0409877531155474 3.42686668939652 0.428571428571429 1.3 1 3 incomplete somite formation 1.05478612071864e-06 9.04751888030216e-05 3.3667462211615 0.421052631578947 1.3 1 3 right-sided stomach 0.000563396911945118 0.0151797119844775 3.3667462211615 0.421052631578947 1.3 1 3 mesocardia 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 impaired embryo implantation 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 interstitial pneumonia 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 dilated bile duct 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 delayed somite formation 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 abnormal patella morphology 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 abnormal aorta elastic tissue morphology 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 abnormal adipose tissue morphology 0.0014738584189487 0.027986433718587 3.29247976040058 0.411764705882353 1.3 1 3 pale yolk sac 2.75637443086033e-12 9.14197519568677e-10 3.27547900432278 0.409638554216867 1.3 1 3 abnormal germ layer development 0.000328971257017055 0.0106969412003912 3.27110002169668 0.409090909090909 1.3 1 3 abnormal cricoid cartilage morphology 0.0038591886022801 0.0554897783131316 3.19840891010342 0.4 1.3 1 3 heterochrony 0.0038591886022801 0.0554897783131316 3.19840891010342 0.4 1.3 1 3 abnormal liver development 1.02220727066378e-05 0.0006054144251848 3.19840891010342 0.4 1.3 1 3 trabecula carnea hypoplasia 5.65957584915933e-07 5.63127796991354e-05 3.19840891010342 0.4 1.3 1 3 abnormal vascular development 2.70474345868321e-09 4.98374026183296e-07 3.14994816904125 0.393939393939394 1.3 1 3 premature aging 0.00011116261537153 0.00432057821463563 3.14129446528015 0.392857142857143 1.3 1 3 hypoxia 0.00011116261537153 0.00432057821463563 3.14129446528015 0.392857142857143 1.3 1 3 abnormal cell differentiation 3.52613766093638e-06 0.000243646317543868 3.12039893668626 0.390243902439024 1.3 1 3 abnormal mitral valve morphology 0.00218185593870613 0.0364252795136342 3.1095642181561 0.388888888888889 1.3 1 3 absent spleen 0.00218185593870613 0.0364252795136342 3.1095642181561 0.388888888888889 1.3 1 3 increased gastrointestinal tumor incidence 0.00218185593870613 0.0364252795136342 3.1095642181561 0.388888888888889 1.3 1 3 excessive scratching 0.010108961617165 0.107946503509852 3.07539318279175 0.384615384615385 1.3 1 3 skin edema 5.10890810286074e-06 0.000334431813312265 3.04610372390802 0.380952380952381 1.3 1 3 left pulmonary isomerism 0.00123697516392952 0.0261870274065929 3.04610372390802 0.380952380952381 1.3 1 3 abnormal tumor vascularization 0.00123697516392952 0.0261870274065929 3.04610372390802 0.380952380952381 1.3 1 3 abnormal tumor morphology 0.000703243733597406 0.0177313755176564 2.99850835322196 0.375 1.3 1 3 delayed hair appearance 0.0055995797052008 0.0699947463150101 2.99850835322196 0.375 1.3 1 3 increased heart left ventricle size 0.0055995797052008 0.0699947463150101 2.99850835322196 0.375 1.3 1 3 abnormal pulmonary alveolus wall morphology 0.0055995797052008 0.0699947463150101 2.99850835322196 0.375 1.3 1 3 abnormal vitelline vasculature morphology 1.69567049935723e-13 7.02996727858518e-11 2.98981702466189 0.373913043478261 1.3 1 3 abnormal vasculogenesis 7.29813263851707e-06 0.000448249504649659 2.97526410242179 0.372093023255814 1.3 1 3 thick pulmonary interalveolar septum 5.34679062597672e-05 0.00235400737736586 2.96995113081032 0.371428571428571 1.3 1 3 short vibrissae 0.00312595703765005 0.0475105071738528 2.94590294351631 0.368421052631579 1.3 1 3 abnormal brain vasculature morphology 0.000229009495745506 0.00804480569389157 2.93187483426147 0.366666666666667 1.3 1 3 liver fibrosis 1.78043620708734e-05 0.000984185570028837 2.92537400314337 0.365853658536585 1.3 1 3 subcutaneous edema 0.000561775456805591 0.0151797119844775 2.85572224116377 0.357142857142857 1.3 1 3 midline facial cleft 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal adrenal gland secretion 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal endplate potential 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 decreased vascular permeability 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 amyloid beta deposits 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 vascular smooth muscle hypoplasia 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal maternal decidual layer morphology 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal viscerocranium morphology 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 increased pulmonary respiratory rate 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 pulmonary alveolar hemorrhage 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal vitelline vein topology 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 pericardial edema 1.31003795428035e-07 1.5142403254946e-05 2.82212550891478 0.352941176470588 1.3 1 3 abnormal interatrial septum morphology 0.00784997313406559 0.0875641622017407 2.82212550891478 0.352941176470588 1.3 1 3 increased cell proliferation 2.75626162509832e-06 0.000204662710221853 2.81341524499838 0.351851851851852 1.3 1 3 abnormal angiogenesis 4.42342540396007e-08 6.11292816241704e-06 2.8094132318476 0.351351351351351 1.3 1 3 abnormal circulating enzyme level 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal dopamine level 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal heart right ventricle morphology 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal induced retinal neovascularization 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal Mullerian duct morphology 0.00136755348912616 0.0269906800615733 2.76785386451258 0.346153846153846 1.3 1 3 blood in lymph vessels 0.000772625021054989 0.018750290145115 2.75724906043398 0.344827586206897 1.3 1 3 abnormal vertebral body morphology 0.00043824309450288 0.0127500549424083 2.74863265712013 0.34375 1.3 1 3 abnormal heart atrium morphology 0.00043824309450288 0.0127500549424083 2.74863265712013 0.34375 1.3 1 3 hemopericardium 8.14130431695888e-05 0.00337524908140587 2.73034906960048 0.341463414634146 1.3 1 3 intracranial hemorrhage 3.96974675269202e-06 0.000270540960200586 2.66534075841952 0.333333333333333 1.3 1 3 incomplete embryo turning 6.87935698158872e-06 0.000433225328903847 2.66534075841952 0.333333333333333 1.3 1 3 abnormal cell adhesion 1.19349670793536e-05 0.000698546602585698 2.66534075841952 0.333333333333333 1.3 1 3 abnormal pharyngeal arch morphology 0.000336496581226238 0.0107123648450191 2.66534075841952 0.333333333333333 1.3 1 3 abnormal retinal blood vessel morphology 0.000336496581226238 0.0107123648450191 2.66534075841952 0.333333333333333 1.3 1 3 abnormal cellular respiration 0.00104443278370973 0.022890101757515 2.66534075841952 0.333333333333333 1.3 1 3 abnormal brain commissure morphology 0.00185090908411396 0.033242861709267 2.66534075841952 0.333333333333333 1.3 1 3 vascular ring 0.00591043143477409 0.0726034478716076 2.66534075841952 0.333333333333333 1.3 1 3 lowered ear position 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 eye inflammation 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 absent inner cell mass 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 darkened coat color 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 jerky movement 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 abnormal enteric neuron morphology 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal pup retrieval 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 placental labyrinth hypoplasia 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal olfactory nerve morphology 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal energy homeostasis 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal coronary vessel morphology 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 decreased circulating serum albumin level 3.32985223590908e-09 5.71241892194747e-07 2.66534075841952 0.333333333333333 1.3 1 3 failure of heart looping 0.000191884112828017 0.00686779468575097 2.66534075841952 0.333333333333333 1.3 1 3 enlarged liver sinusoidal spaces 0.000787699322473326 0.0190233210160427 2.58694838317188 0.323529411764706 1.3 1 3 abnormal object recognition memory 0.0013896427792452 0.0270487357011144 2.57936202427695 0.32258064516129 1.3 1 3 pale kidney 0.0013896427792452 0.0270487357011144 2.57936202427695 0.32258064516129 1.3 1 3 lymphoid hyperplasia 0.00246155132862844 0.039760447597164 2.57015001704739 0.321428571428571 1.3 1 3 absent corpus callosum 0.00246155132862844 0.039760447597164 2.57015001704739 0.321428571428571 1.3 1 3 small liver 5.98813655691983e-07 5.84136850405415e-05 2.56282765232646 0.320512820512821 1.3 1 3 spontaneous skin ulceration 0.0043819873825023 0.0593321035056049 2.55872712808274 0.32 1.3 1 3 abnormal tail movements 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 abnormal basement membrane morphology 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 abnormal blood-brain barrier function 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 increased circulating creatine kinase level 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 abnormal blood vessel morphology 2.07162314545167e-11 6.0625442050718e-09 2.53666913559926 0.317241379310345 1.3 1 3 lethality throughout fetal growth and development, complete penetrance 2.48284747481348e-14 1.23521661871971e-11 2.52505966587112 0.315789473684211 1.3 1 3 absent vitelline blood vessels 2.75399042465043e-05 0.00139807166965672 2.52505966587112 0.315789473684211 1.3 1 3 abnormal stationary movement 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 maternal imprinting 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 oliguria 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 decreased liver glycogen level 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 thin interventricular septum 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 abnormal apoptosis 4.77586024015648e-05 0.00215999133588896 2.51726627184066 0.314814814814815 1.3 1 3 scoliosis 0.0018220971814008 0.0328439618748876 2.4987569610183 0.3125 1.3 1 3 abnormal spongiotrophoblast layer morphology 0.0018220971814008 0.0328439618748876 2.4987569610183 0.3125 1.3 1 3 abnormal hair follicle orientation 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 disorganized yolk sac vascular plexus 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 blepharitis 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 thin ventricular wall 2.60377038820884e-07 2.75611865560404e-05 2.48765137452488 0.311111111111111 1.3 1 3 abnormal cell migration 0.000251068645124223 0.00861455206628896 2.48765137452488 0.311111111111111 1.3 1 3 abnormal spinal nerve morphology 0.00322156816703651 0.0480215776484043 2.48152415439059 0.310344827586207 1.3 1 3 increased mortality induced by gamma-irradiation 0.00322156816703651 0.0480215776484043 2.48152415439059 0.310344827586207 1.3 1 3 abnormal embryonic erythropoiesis 0.00322156816703651 0.0480215776484043 2.48152415439059 0.310344827586207 1.3 1 3 decreased circulating total protein level 6.20086748326738e-05 0.00268254919384828 2.47149779417083 0.309090909090909 1.3 1 3 ventricular septal defect 3.88329797451136e-10 8.78154882872456e-08 2.46935982030044 0.308823529411765 1.3 1 3 increased vascular permeability 0.000765626574239814 0.0186715304257013 2.4603145462334 0.307692307692308 1.3 1 3 increased hepatocyte apoptosis 0.000765626574239814 0.0186715304257013 2.4603145462334 0.307692307692308 1.3 1 3 abnormal stomach morphology 0.00572173577955835 0.0709866222027501 2.4603145462334 0.307692307692308 1.3 1 3 thick skin 0.00572173577955835 0.0709866222027501 2.4603145462334 0.307692307692308 1.3 1 3 abnormal ocular fundus morphology 0.00572173577955835 0.0709866222027501 2.4603145462334 0.307692307692308 1.3 1 3 hemorrhage 4.06326646820573e-16 2.88782152561764e-13 2.44984512263241 0.306382978723404 1.3 1 3 impaired wound healing 0.00134150744248058 0.0269906800615733 2.44322902855122 0.305555555555556 1.3 1 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0102191294556241 0.108632839832756 2.43357199681782 0.304347826086957 1.3 1 3 abnormal aorta morphology 0.00235700483553902 0.0386999968871506 2.42303705310865 0.303030303030303 1.3 1 3 dilated heart atrium 0.00235700483553902 0.0386999968871506 2.42303705310865 0.303030303030303 1.3 1 3 kidney failure 0.000564471701935345 0.0151797119844775 2.4174020832177 0.302325581395349 1.3 1 3 atrioventricular septal defect 0.000138209350654181 0.0051312799963026 2.41389351705919 0.30188679245283 1.3 1 3 decreased embryo size 5.72152563966077e-30 1.42322950286562e-26 2.40884353062182 0.301255230125523 1.3 1 3 perinatal lethality, incomplete penetrance 7.19113338668787e-15 3.97509873319691e-12 2.40588280848487 0.300884955752212 1.3 1 3 embryonic lethality during organogenesis, complete penetrance 1.57690296070664e-34 7.84509222951553e-31 2.39880668257757 0.3 1.3 1 3 embryonic lethality between somite formation and embryo turning, complete penetrance 1.48058288872031e-05 0.000837034076293582 2.39880668257757 0.3 1.3 1 3 delayed eyelid opening 0.00415462618846228 0.0580597339539321 2.39880668257757 0.3 1.3 1 3 abnormal lactation 0.00415462618846228 0.0580597339539321 2.39880668257757 0.3 1.3 1 3 abnormal basioccipital bone morphology 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 abnormal trachea morphology 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 kidney atrophy 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 abnormal neuron proliferation 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 double outlet right ventricle 1.0542061760098e-07 1.27918920137775e-05 2.39133376456331 0.299065420560748 1.3 1 3 internal hemorrhage 2.5453448912392e-05 0.00130547328184691 2.3868723209727 0.298507462686567 1.3 1 3 abnormal cell morphology 4.6070751311753e-08 6.1946483182695e-06 2.38477857332273 0.298245614035088 1.3 1 3 abnormal axon morphology 1.33922762455804e-07 1.5142403254946e-05 2.36919178526179 0.296296296296296 1.3 1 3 abnormal atrioventricular cushion morphology 0.00735155754606126 0.084332572838004 2.36919178526179 0.296296296296296 1.3 1 3 corneal opacity 1.88355116606414e-05 0.00101855076643143 2.3650206729638 0.295774647887324 1.3 1 3 lethality, incomplete penetrance 0.000720456417462364 0.0178362275017734 2.36246112678094 0.295454545454545 1.3 1 3 abnormal extraembryonic tissue morphology 3.8905500094006e-07 4.03239297849333e-05 2.35177125742899 0.294117647058824 1.3 1 3 overexpanded pulmonary alveoli 0.00301088213264973 0.0463750421360136 2.35177125742899 0.294117647058824 1.3 1 3 increased incidence of corneal inflammation 0.0333662835088736 0.218035104423838 2.35177125742899 0.294117647058824 1.3 1 3 common atrium 0.0333662835088736 0.218035104423838 2.35177125742899 0.294117647058824 1.3 1 3 delayed heart development 0.0333662835088736 0.218035104423838 2.35177125742899 0.294117647058824 1.3 1 3 scaly skin 0.00125232123214034 0.0262441879627655 2.3402992025147 0.292682926829268 1.3 1 3 increased bone trabecula number 0.00125232123214034 0.0262441879627655 2.3402992025147 0.292682926829268 1.3 1 3 small heart 0.000526558965423603 0.0147009626754362 2.33217316361708 0.291666666666667 1.3 1 3 abnormal lymph node morphology 0.000526558965423603 0.0147009626754362 2.33217316361708 0.291666666666667 1.3 1 3 vertebral transformation 0.000526558965423603 0.0147009626754362 2.33217316361708 0.291666666666667 1.3 1 3 decreased body height 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 abnormal body weight 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 ocular hypertelorism 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 abnormal vasodilation 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 abnormal inner cell mass apoptosis 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 pericardial effusion 9.51755753958909e-05 0.00384958119995575 2.32142582184926 0.290322580645161 1.3 1 3 abnormal eyelid morphology 0.00528575576496017 0.0669127545739668 2.32142582184926 0.290322580645161 1.3 1 3 microcephaly 4.07838310603351e-05 0.00191414678797327 2.31768761601697 0.289855072463768 1.3 1 3 albuminuria 0.000911145199974733 0.0210834761389502 2.30996199063025 0.288888888888889 1.3 1 3 small placenta 0.000911145199974733 0.0210834761389502 2.30996199063025 0.288888888888889 1.3 1 3 distended pericardium 0.000384449412869256 0.0113847370775271 2.30654488709381 0.288461538461538 1.3 1 3 abnormal eye morphology 9.72515776731351e-09 1.56073096427047e-06 2.30101360439095 0.287769784172662 1.3 1 3 abnormal cell cycle 1.98237144707343e-07 2.14397781504137e-05 2.2945107398568 0.28695652173913 1.3 1 3 disheveled coat 0.0015780543751469 0.0294393115206974 2.28457779293102 0.285714285714286 1.3 1 3 abnormal cytotoxic T cell physiology 0.0015780543751469 0.0294393115206974 2.28457779293102 0.285714285714286 1.3 1 3 abnormal eye pigmentation 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 trunk curl 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 complete atrioventricular septal defect 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 absent segment of posterior cerebral artery 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 abnormal embryonic tissue morphology 5.31659601415807e-09 8.81668839014546e-07 2.28457779293101 0.285714285714286 1.3 1 3 ovary cysts 0.00380146666953736 0.0551378911981002 2.28457779293101 0.285714285714286 1.3 1 3 rib bifurcation 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 straub tail 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 corneal vascularization 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 abnormal renal tubule epithelium morphology 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 lethality throughout fetal growth and development, incomplete penetrance 1.44263511152795e-10 3.77742614729029e-08 2.27819629071612 0.284916201117318 1.3 1 3 edema 3.29346009498808e-10 7.80236379645985e-08 2.27793657841668 0.284883720930233 1.3 1 3 abnormal heart development 1.71833189166719e-09 3.41948046441771e-07 2.27734811637111 0.284810126582278 1.3 1 3 kidney cysts 3.7488663823707e-05 0.0017762485954566 2.26914145649229 0.283783783783784 1.3 1 3 abnormal cell death 0.00114233172815611 0.0246021660068254 2.25974542561655 0.282608695652174 1.3 1 3 abnormal allantois morphology 0.00114233172815611 0.0246021660068254 2.25974542561655 0.282608695652174 1.3 1 3 increased fibroblast apoptosis 0.00664110042809209 0.07999872791709 2.24888126491647 0.28125 1.3 1 3 abnormal facial morphology 0.000350112951294919 0.0108934676806607 2.24449748077433 0.280701754385965 1.3 1 3 pallor 6.32262192573196e-10 1.36761061219637e-07 2.23888623707239 0.28 1.3 1 3 abnormal interventricular septum morphology 0.000827117456975721 0.0197832180214145 2.23888623707239 0.28 1.3 1 3 abnormal circulating protein level 0.000827117456975721 0.0197832180214145 2.23888623707239 0.28 1.3 1 3 abnormal keratinocyte physiology 0.0164479095163502 0.139638822259116 2.23888623707239 0.28 1.3 1 3 increased cellular sensitivity to ionizing radiation 0.0164479095163502 0.139638822259116 2.23888623707239 0.28 1.3 1 3 decreased placenta weight 0.0164479095163502 0.139638822259116 2.23888623707239 0.28 1.3 1 3 delayed endochondral bone ossification 0.00197040895832558 0.0334566026200333 2.23144807681634 0.27906976744186 1.3 1 3 abnormal placenta morphology 3.40807261040854e-05 0.00164613215891092 2.22674038045175 0.278481012658228 1.3 1 3 abnormal myocardium layer morphology 3.40807261040854e-05 0.00164613215891092 2.22674038045175 0.278481012658228 1.3 1 3 decreased tumor growth/size 0.000599093884040762 0.0158536812399085 2.22111729868293 0.277777777777778 1.3 1 3 abnormal bile duct morphology 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 acidosis 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 decreased tumor latency 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 increased effector memory CD4-positive, alpha-beta T cell number 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 increased effector memory CD8-positive, alpha-beta T cell number 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 abnormal hypoglossal nerve topology 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 hepatic necrosis 0.00142041741844087 0.0274964072246821 2.21166573570981 0.276595744680851 1.3 1 3 decreased trophoblast giant cell number 0.0116260331248431 0.114449888811311 2.20579924834719 0.275862068965517 1.3 1 3 increased susceptibility to induced arthritis 0.0116260331248431 0.114449888811311 2.20579924834719 0.275862068965517 1.3 1 3 increased lymphocyte cell number 0.00013454558623852 0.00507094160255028 2.20180323521612 0.27536231884058 1.3 1 3 distended abdomen 0.00102484196630916 0.0226603945883915 2.19498650693372 0.274509803921569 1.3 1 3 abnormal trophoblast layer morphology 0.00102484196630916 0.0226603945883915 2.19498650693372 0.274509803921569 1.3 1 3 failure of chorioallantoic fusion 0.00102484196630916 0.0226603945883915 2.19498650693372 0.274509803921569 1.3 1 3 hydronephrosis 3.0699538560446e-05 0.00151218024097246 2.18938705155889 0.273809523809524 1.3 1 3 alopecia 9.69504472964631e-06 0.000581118644939643 2.18838504375497 0.273684210526316 1.3 1 3 kyphosis 3.22216000205481e-08 4.58007028863506e-06 2.185579421904 0.273333333333333 1.3 1 3 abnormal rostral-caudal axis patterning 0.000740061548291045 0.0182267633799404 2.18073334779779 0.272727272727273 1.3 1 3 omphalocele 0.00243914116114927 0.0396559714925413 2.18073334779779 0.272727272727273 1.3 1 3 decreased blood urea nitrogen level 0.00243914116114927 0.0396559714925413 2.18073334779779 0.272727272727273 1.3 1 3 decreased sensitivity to induced morbidity/mortality 0.00243914116114927 0.0396559714925413 2.18073334779779 0.272727272727273 1.3 1 3 myeloid hyperplasia 0.00824763627529948 0.0913852794423495 2.18073334779779 0.272727272727273 1.3 1 3 increased skin papilloma incidence 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 increased myocardial infarction size 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 decreased cardiac output 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 cleft upper lip 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 decreased circulating estradiol level 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 abnormal occipital bone morphology 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 rough coat 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 increased mammary gland tumor incidence 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 syndactyly 0.000534849094322402 0.0147009626754362 2.1684128204091 0.271186440677966 1.3 1 3 curly tail 0.00175242198670441 0.0318186108899797 2.16558936621586 0.270833333333333 1.3 1 3 malocclusion 0.0058691150822334 0.0722743750844336 2.16108710142123 0.27027027027027 1.3 1 3 increased circulating phosphate level 0.0058691150822334 0.0722743750844336 2.16108710142123 0.27027027027027 1.3 1 3 eyelids open at birth 0.00126077606494491 0.0262441879627655 2.15277522795423 0.269230769230769 1.3 1 3 abnormal hair growth 0.00126077606494491 0.0262441879627655 2.15277522795423 0.269230769230769 1.3 1 3 small seminal vesicle 0.0203996577351682 0.161128112139528 2.15277522795423 0.269230769230769 1.3 1 3 pulmonary edema 0.0203996577351682 0.161128112139528 2.15277522795423 0.269230769230769 1.3 1 3 abnormal cornea morphology 8.7297021215511e-05 0.00358927835162948 2.15277522795423 0.269230769230769 1.3 1 3 disorganized myocardium 0.0143429083744362 0.124748197837098 2.13227260673561 0.266666666666667 1.3 1 3 liver hemorrhage 0.0143429083744362 0.124748197837098 2.13227260673561 0.266666666666667 1.3 1 3 abnormal fat pad morphology 0.0143429083744362 0.124748197837098 2.13227260673561 0.266666666666667 1.3 1 3 embryonic growth arrest 5.26065994667434e-11 1.4539879574836e-08 2.12994479821298 0.266375545851528 1.3 1 3 abnormal epidermis stratum corneum morphology 0.00214598728709257 0.0361908025535102 2.12139366486451 0.26530612244898 1.3 1 3 increased fluid intake 0.00214598728709257 0.0361908025535102 2.12139366486451 0.26530612244898 1.3 1 3 decreased mean corpuscular hemoglobin 0.000341636694825851 0.0107572313718899 2.11659413168609 0.264705882352941 1.3 1 3 abnormal nervous system development 0.0101328677666534 0.107946503509852 2.11659413168609 0.264705882352941 1.3 1 3 abnormal direction of heart looping 0.0101328677666534 0.107946503509852 2.11659413168609 0.264705882352941 1.3 1 3 abnormal cardiovascular system physiology 8.46174784071714e-07 7.6540355468305e-05 2.10421638822593 0.263157894736842 1.3 1 3 abnormal triglyceride level 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 flaky skin 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 thin dermal layer 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 delayed sexual maturation 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 decreased tumor incidence 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 abnormal nasal septum morphology 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 abnormal pancreas morphology 0.00511362830792872 0.0652315405947318 2.09419631018676 0.261904761904762 1.3 1 3 abnormal muscle morphology 0.00511362830792872 0.0652315405947318 2.09419631018676 0.261904761904762 1.3 1 3 thymus hypoplasia 7.46538348874641e-07 7.00760053896479e-05 2.08591885441527 0.260869565217391 1.3 1 3 atrial septal defect 0.00364857993658034 0.0537032106049917 2.08591885441527 0.260869565217391 1.3 1 3 abnormal pulmonary artery morphology 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 abnormal cranial nerve morphology 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 conjunctivitis 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 abnormal hematopoietic stem cell physiology 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 abnormal axon extension 0.00260937398416064 0.0413367968673572 2.07896579156722 0.26 1.3 1 3 abnormal maxilla morphology 0.00186994157851965 0.0332577451601639 2.07304281210407 0.259259259259259 1.3 1 3 abnormal neuronal precursor proliferation 0.00186994157851965 0.0332577451601639 2.07304281210407 0.259259259259259 1.3 1 3 abnormal heart valve morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 abnormal trigeminal nerve morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 abnormal type II pneumocyte morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 cryptorchism 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 abnormal eye muscle morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 thick interventricular septum 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 increased heart weight 9.00493201006334e-07 7.85956785088862e-05 2.07091224395186 0.258992805755396 1.3 1 3 abnormal podocyte morphology 0.0174932223255582 0.146021444747738 2.06348961942156 0.258064516129032 1.3 1 3 preaxial polydactyly 0.0174932223255582 0.146021444747738 2.06348961942156 0.258064516129032 1.3 1 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0174932223255582 0.146021444747738 2.06348961942156 0.258064516129032 1.3 1 3 abnormal kidney morphology 5.26226718639407e-08 6.88941559271329e-06 2.05612001363791 0.257142857142857 1.3 1 3 abnormal hippocampus pyramidal cell morphology 0.0123245066079628 0.114449888811311 2.05612001363791 0.257142857142857 1.3 1 3 decreased bone mineralization 0.0123245066079628 0.114449888811311 2.05612001363791 0.257142857142857 1.3 1 3 abnormal heart looping 0.00872141455134676 0.0955705669448241 2.05026212186117 0.256410256410256 1.3 1 3 abnormal circulating hormone level 0.00872141455134676 0.0955705669448241 2.05026212186117 0.256410256410256 1.3 1 3 anemia 3.09988982375622e-09 5.50783995470971e-07 2.04637536902352 0.255924170616114 1.3 1 3 abnormal axon guidance 0.00619410995935481 0.0755286692347798 2.04549407041498 0.255813953488372 1.3 1 3 abnormal double-strand DNA break repair 0.00619410995935481 0.0755286692347798 2.04549407041498 0.255813953488372 1.3 1 3 abnormal cervical vertebrae morphology 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 increased kidney weight 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 abnormal thrombosis 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 abnormal dendritic spine morphology 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 decreased susceptibility to hepatic steatosis 0.00116209283781445 0.0249198787419262 2.03073581593868 0.253968253968254 1.3 1 3 abnormal rib morphology 3.51125842232794e-06 0.000243646317543868 2.01381301747252 0.251851851851852 1.3 1 3 abnormal eating behavior 0.00193864243144674 0.0332577451601639 1.99900556881464 0.25 1.3 1 3 abnormal eye physiology 0.00193864243144674 0.0332577451601639 1.99900556881464 0.25 1.3 1 3 muscular ventricular septal defect 0.00193864243144674 0.0332577451601639 1.99900556881464 0.25 1.3 1 3 abnormal placenta vasculature 0.00378167561449814 0.0551378911981002 1.99900556881464 0.25 1.3 1 3 enlarged heart 2.13685942138429e-09 4.08879831591801e-07 1.99900556881464 0.25 1.3 1 3 insulin resistance 5.75376312462611e-06 0.000366986814679678 1.99900556881464 0.25 1.3 1 3 hydrops fetalis 0.000720619442785215 0.0178362275017734 1.99900556881464 0.25 1.3 1 3 decreased circulating LDL cholesterol level 0.00139185454060006 0.0270487357011144 1.99900556881464 0.25 1.3 1 3 overriding aortic valve 0.00529922116625988 0.0669127545739668 1.99900556881464 0.25 1.3 1 3 abnormal systemic arterial blood pressure 0.0148501405326871 0.128262932552289 1.99900556881464 0.25 1.3 1 3 abnormal epidermis stratum granulosum morphology 0.0148501405326871 0.128262932552289 1.99900556881464 0.25 1.3 1 3 renal hypoplasia 0.0148501405326871 0.128262932552289 1.99900556881464 0.25 1.3 1 3 abnormal diaphragm morphology 0.0211105962913803 0.161128112139528 1.99900556881464 0.25 1.3 1 3 decreased metastatic potential 0.043489035088988 0.261934563641302 1.99900556881464 0.25 1.3 1 3 decreased ovulation rate 0.043489035088988 0.261934563641302 1.99900556881464 0.25 1.3 1 3 abnormal hyoid bone morphology 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 decreased skin tensile strength 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 absent placental labyrinth 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal male reproductive system physiology 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal response to tactile stimuli 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal sperm mitochondrial sheath morphology 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 increased skin tumor incidence 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal heart electrocardiography waveform feature 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal seminal vesicle morphology 0.00270494123023933 0.0423178698755996 1.99900556881464 0.25 1.3 1 3 small superior cervical ganglion 0.0301861370574627 0.208642081239391 1.99900556881464 0.25 1.3 1 3 abnormal ovulation 0.0301861370574627 0.208642081239391 1.99900556881464 0.25 1.3 1 3 abnormal hormone level 0.0301861370574627 0.208642081239391 1.99900556881464 0.25 1.3 1 3 decreased cell proliferation 1.11377040983143e-07 1.31928756878842e-05 1.98820013330753 0.248648648648649 1.3 1 3 anophthalmia 0.000233116964383395 0.00811018809655518 1.97654483208638 0.247191011235955 1.3 1 3 abnormal lung development 0.000322464059775767 0.010554333535424 1.97548785624035 0.247058823529412 1.3 1 3 abnormal neural tube morphology 8.80425897763801e-07 7.82164078816948e-05 1.97432648771816 0.246913580246914 1.3 1 3 decreased heart weight 0.000446453237718673 0.0129134003351767 1.97432648771816 0.246913580246914 1.3 1 3 decreased total body fat amount 3.12879511014963e-12 9.7285972956215e-10 1.96309528913533 0.245508982035928 1.3 1 3 extramedullary hematopoiesis 7.60955170850998e-05 0.00318130418065858 1.96128848261059 0.245283018867925 1.3 1 3 cardiac hypertrophy 0.000144866142034922 0.00533858560462029 1.95820953679801 0.244897959183673 1.3 1 3 increased insulin sensitivity 5.08818623942199e-06 0.000334431813312265 1.9570683890493 0.244755244755245 1.3 1 3 prenatal lethality, complete penetrance 2.54677883768962e-10 6.33511235875293e-08 1.95586156373231 0.244604316546763 1.3 1 3 sparse hair 0.000529561063951702 0.0147009626754362 1.95024933542892 0.24390243902439 1.3 1 3 lethality at weaning, incomplete penetrance 0.0125298685304873 0.11522383722583 1.95024933542892 0.24390243902439 1.3 1 3 decreased T cell proliferation 4.37557088867655e-06 0.000294168448258998 1.94497839127911 0.243243243243243 1.3 1 3 abnormal intestine morphology 0.00101813431877975 0.0226603945883915 1.94497839127911 0.243243243243243 1.3 1 3 pale liver 0.00101813431877975 0.0226603945883915 1.94497839127911 0.243243243243243 1.3 1 3 increased white adipose tissue amount 0.0177368987131901 0.147807489276584 1.94497839127911 0.243243243243243 1.3 1 3 abnormal heart morphology 1.30362565411018e-08 2.00428307076468e-06 1.93842964248692 0.242424242424242 1.3 1 3 abnormal tooth development 0.0252267434965261 0.18565539777399 1.93842964248692 0.242424242424242 1.3 1 3 belly spot 0.0252267434965261 0.18565539777399 1.93842964248692 0.242424242424242 1.3 1 3 abnormal epidermis stratum basale morphology 0.0252267434965261 0.18565539777399 1.93842964248692 0.242424242424242 1.3 1 3 decreased circulating HDL cholesterol level 2.14526750284732e-05 0.0011476027770608 1.93653664478918 0.2421875 1.3 1 3 increased blood urea nitrogen level 7.08324839702736e-06 0.000440489509690139 1.93007434230379 0.241379310344828 1.3 1 3 glomerulosclerosis 0.00382405199036137 0.0553042402675809 1.93007434230379 0.241379310344828 1.3 1 3 abnormal middle ear morphology 0.0360916246723871 0.224133858141094 1.93007434230379 0.241379310344828 1.3 1 3 abnormal outer ear morphology 0.0360916246723871 0.224133858141094 1.93007434230379 0.241379310344828 1.3 1 3 short snout 0.000106142688830671 0.00419095140422688 1.92496832552521 0.240740740740741 1.3 1 3 abnormal somite development 0.000866978334676251 0.0202498460798796 1.9230939649356 0.240506329113924 1.3 1 3 abnormal placenta labyrinth morphology 0.000866978334676251 0.0202498460798796 1.9230939649356 0.240506329113924 1.3 1 3 decreased B cell proliferation 0.000866978334676251 0.0202498460798796 1.9230939649356 0.240506329113924 1.3 1 3 decreased heart rate 0.000201913731931678 0.00717514868828643 1.91904534606205 0.24 1.3 1 3 short stride length 0.00749426560178791 0.0851108776175784 1.91904534606205 0.24 1.3 1 3 increased B cell derived lymphoma incidence 0.00749426560178791 0.0851108776175784 1.91904534606205 0.24 1.3 1 3 decreased oocyte number 0.00749426560178791 0.0851108776175784 1.91904534606205 0.24 1.3 1 3 ruffled hair 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 mandible hypoplasia 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 abnormal feces composition 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 diaphragmatic hernia 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 increased liver glycogen level 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 abnormal CD4-positive, alpha-beta T cell physiology 0.00166983946108782 0.030654801914804 1.91454054478022 0.23943661971831 1.3 1 3 failure to gastrulate 0.0105317735344097 0.110772882312237 1.912092283214 0.239130434782609 1.3 1 3 abnormal myelin sheath morphology 0.0105317735344097 0.110772882312237 1.912092283214 0.239130434782609 1.3 1 3 small kidney 0.000532383525926659 0.0147009626754362 1.90814167932306 0.238636363636364 1.3 1 3 abnormal associative learning 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 abnormal clavicle morphology 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 embryonic lethality at implantation, complete penetrance 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 increased muscle cell glucose uptake 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 abnormal erythropoiesis 0.000172043180490621 0.00620228132565826 1.90381482744251 0.238095238095238 1.3 1 3 persistence of hyaloid vascular system 0.0210111202760751 0.161128112139528 1.89379474940334 0.236842105263158 1.3 1 3 increased grooming behavior 0.0210111202760751 0.161128112139528 1.89379474940334 0.236842105263158 1.3 1 3 decreased neuron apoptosis 0.0210111202760751 0.161128112139528 1.89379474940334 0.236842105263158 1.3 1 3 embryonic lethality between implantation and somite formation, complete penetrance 1.81463664978422e-08 2.65524039196368e-06 1.89293588557141 0.236734693877551 1.3 1 3 abnormal platelet physiology 0.00630405472319218 0.0763082049826791 1.88996890142475 0.236363636363636 1.3 1 3 abnormal neuromuscular synapse morphology 0.00196323473947225 0.0334489480440906 1.88794970388049 0.236111111111111 1.3 1 3 abnormal heart left ventricle morphology 0.00196323473947225 0.0334489480440906 1.88794970388049 0.236111111111111 1.3 1 3 decreased T cell number 5.18873856292166e-06 0.000335246420136821 1.88725991589953 0.236024844720497 1.3 1 3 short maxilla 0.0298710129518715 0.207553476865308 1.88141700594319 0.235294117647059 1.3 1 3 lung hemorrhage 0.0298710129518715 0.207553476865308 1.88141700594319 0.235294117647059 1.3 1 3 thin skin 0.0298710129518715 0.207553476865308 1.88141700594319 0.235294117647059 1.3 1 3 impaired hematopoiesis 0.00883051633245811 0.0961308944288383 1.88141700594319 0.235294117647059 1.3 1 3 abnormal gastrulation 0.00883051633245811 0.0961308944288383 1.88141700594319 0.235294117647059 1.3 1 3 abnormal gluconeogenesis 0.00883051633245811 0.0961308944288383 1.88141700594319 0.235294117647059 1.3 1 3 preweaning lethality, complete penetrance 3.26102821811226e-22 3.2447230770217e-19 1.88014577823647 0.235135135135135 1.3 1 3 decreased circulating cholesterol level 1.46635663891832e-06 0.000121585404643644 1.87884676413179 0.234972677595628 1.3 1 3 embryonic lethality during organogenesis, incomplete penetrance 7.40732208985984e-08 9.21285684926317e-06 1.87732696897375 0.234782608695652 1.3 1 3 increased sacral vertebrae number 0.0037971840704467 0.0551378911981002 1.87406772076372 0.234375 1.3 1 3 decreased hemoglobin content 2.51837216752527e-05 0.00130547328184691 1.87140946867753 0.234042553191489 1.3 1 3 increased respiratory quotient 0.0124015450286716 0.11447445765519 1.87140946867753 0.234042553191489 1.3 1 3 polyuria 0.00165722695086746 0.030535941039132 1.8692000123981 0.233766233766234 1.3 1 3 abnormal incisor morphology 0.00529319555815841 0.0669127545739668 1.86573853089366 0.233333333333333 1.3 1 3 increased metastatic potential 0.0427107991978505 0.258499058405482 1.86573853089366 0.233333333333333 1.3 1 3 abnormal optic cup morphology 0.0427107991978505 0.258499058405482 1.86573853089366 0.233333333333333 1.3 1 3 decreased bone marrow cell number 0.00229862534648149 0.0379922295639382 1.8620873791698 0.232876712328767 1.3 1 3 increased oxygen consumption 0.00101003472172981 0.0226603945883915 1.85954006401362 0.232558139534884 1.3 1 3 abnormal left-right axis patterning 0.017469665915395 0.146021444747738 1.85954006401362 0.232558139534884 1.3 1 3 abnormal homeostasis 0.017469665915395 0.146021444747738 1.85954006401362 0.232558139534884 1.3 1 3 impaired macrophage phagocytosis 0.017469665915395 0.146021444747738 1.85954006401362 0.232558139534884 1.3 1 3 preweaning lethality, incomplete penetrance 2.01841392177314e-12 7.17257804344385e-10 1.85726678765174 0.232273838630807 1.3 1 3 decreased cardiac muscle contractility 0.000378230608446405 0.0112676483653944 1.84523590967505 0.230769230769231 1.3 1 3 increased grip strength 0.000851977975319096 0.0201837639391072 1.84523590967505 0.230769230769231 1.3 1 3 abnormal snout morphology 0.0103451685478461 0.1095440880032 1.84523590967505 0.230769230769231 1.3 1 3 abnormal leukocyte cell number 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 abnormal kidney cortex morphology 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 heart inflammation 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 decreased circulating glycerol level 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 abnormal erythrocyte osmotic lysis 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 decreased bone resorption 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 decreased Peyer's patch number 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 increased urine protein level 0.00193423177354845 0.0332577451601639 1.84523590967505 0.230769230769231 1.3 1 3 abnormal heart ventricle morphology 0.00193423177354845 0.0332577451601639 1.84523590967505 0.230769230769231 1.3 1 3 abnormal liver physiology 0.000520991227289994 0.0147009626754362 1.83908512330947 0.23 1.3 1 3 abnormal retinal pigmentation 0.00117659249718262 0.025122522203792 1.83816604028932 0.229885057471264 1.3 1 3 abnormal renal glomerulus morphology 0.000319333447842947 0.0105210854504547 1.8339500631327 0.229357798165138 1.3 1 3 abnormal embryonic epiblast morphology 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 decreased glycogen level 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 decreased bone volume 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 impaired adaptive thermogenesis 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 increased macrophage cell number 0.00862335422847807 0.0949141311652177 1.82365420312914 0.228070175438596 1.3 1 3 abnormal embryo development 7.43322039952168e-05 0.00316070696475388 1.82262272450746 0.227941176470588 1.3 1 3 increased leukocyte cell number 4.58537118164333e-05 0.00209286436960326 1.81978437988643 0.227586206896552 1.3 1 3 thrombocytopenia 4.58537118164333e-05 0.00209286436960326 1.81978437988643 0.227586206896552 1.3 1 3 abnormal suckling behavior 0.00136606572402261 0.0269906800615733 1.81727778983149 0.227272727272727 1.3 1 3 abnormal circadian rhythm 0.0204178717065631 0.161128112139528 1.81727778983149 0.227272727272727 1.3 1 3 increased activated T cell number 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal tracheal cartilage morphology 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 prolonged PR interval 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal circulating lipid level 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal limb posture 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal sperm midpiece morphology 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 increased adenoma incidence 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 increased bone volume 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 spleen hyperplasia 0.00311374212815836 0.0475105071738528 1.81243171572527 0.226666666666667 1.3 1 3 abnormal limb morphology 0.00311374212815836 0.0475105071738528 1.81243171572527 0.226666666666667 1.3 1 3 abnormal coat/ hair morphology 0.0120530023096861 0.114449888811311 1.81042013779439 0.226415094339623 1.3 1 3 prenatal lethality 0.00718528070033657 0.084332572838004 1.80555341699387 0.225806451612903 1.3 1 3 decreased thymus weight 0.0500659257856024 0.283507410637996 1.80555341699387 0.225806451612903 1.3 1 3 inner cell mass degeneration 0.0500659257856024 0.283507410637996 1.80555341699387 0.225806451612903 1.3 1 3 abnormal CD8-positive, alpha beta T cell morphology 0.0500659257856024 0.283507410637996 1.80555341699387 0.225806451612903 1.3 1 3 abnormal skeletal muscle fiber morphology 0.00431492877111406 0.0593321035056049 1.80192051273432 0.225352112676056 1.3 1 3 liver inflammation 0.000262458040484954 0.00884917156928513 1.79910501193317 0.225 1.3 1 3 abnormal retinal pigment epithelium morphology 0.00260594038833334 0.0413367968673572 1.79910501193317 0.225 1.3 1 3 abnormal craniofacial development 0.0168841705633738 0.142370760258957 1.79502540873151 0.224489795918367 1.3 1 3 rib fusion 0.00598602639985533 0.073350939259311 1.79015424072953 0.223880597014925 1.3 1 3 prenatal lethality, incomplete penetrance 1.32947419769315e-08 2.00428307076468e-06 1.78858392999204 0.223684210526316 1.3 1 3 decreased B cell number 2.88481382889875e-06 0.000207999257953207 1.78551953719366 0.223300970873786 1.3 1 3 neonatal lethality, incomplete penetrance 1.64778543544716e-07 1.82171834252213e-05 1.78372804601922 0.223076923076923 1.3 1 3 reduced fertility 0.000114255964512465 0.00440638312751562 1.78328554340299 0.223021582733813 1.3 1 3 abnormal long bone epiphyseal plate proliferative zone 0.0139689504817676 0.124748197837098 1.77689383894635 0.222222222222222 1.3 1 3 abnormal trigeminal ganglion morphology 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 increased brain weight 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 abnormal fetal cardiomyocyte proliferation 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 decreased bone ossification 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 increased circulating alkaline phosphatase level 3.65584866006617e-05 0.00174883145036819 1.77689383894634 0.222222222222222 1.3 1 3 microphthalmia 5.92487452482924e-05 0.0025856360316689 1.77689383894634 0.222222222222222 1.3 1 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.00498684135158314 0.064700150217769 1.77689383894634 0.222222222222222 1.3 1 3 abnormal lysosome morphology 0.0408470741550324 0.250263785617347 1.77689383894634 0.222222222222222 1.3 1 3 abnormal ectoderm development 0.0237127514922475 0.177935050790243 1.77689383894634 0.222222222222222 1.3 1 3 increased inflammatory response 0.0015254380055153 0.0287464169599947 1.76754176610979 0.221052631578947 1.3 1 3 perinatal lethality, complete penetrance 3.2033604180306e-06 0.000227667401138604 1.76438050205236 0.220657276995305 1.3 1 3 decreased double-positive T cell number 0.00127579496729288 0.0264461665095087 1.75912490055688 0.22 1.3 1 3 increased body length 0.0195326052961288 0.155978669900868 1.75912490055688 0.22 1.3 1 3 reduced female fertility 1.41026221146806e-06 0.000118916178000908 1.75774627602666 0.219827586206897 1.3 1 3 respiratory distress 2.9690494426935e-05 0.00147710209774002 1.75635171364061 0.219653179190751 1.3 1 3 thick ventricular wall 0.0334034453730038 0.218035104423838 1.75522440188602 0.219512195121951 1.3 1 3 decreased hematocrit 0.000126483790341696 0.00480348745763309 1.75255282745393 0.219178082191781 1.3 1 3 seminiferous tubule degeneration 0.00574142830038359 0.0710537457572347 1.75255282745393 0.219178082191781 1.3 1 3 cyanosis 1.29887027492046e-05 0.000742744783647047 1.74912987271281 0.21875 1.3 1 3 kidney cortex cysts 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 polydipsia 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 bradykinesia 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 increased fatty acid level 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 pancreatic islet hyperplasia 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 abnormal lung morphology 0.000545869552690135 0.0149214342012825 1.74703007694725 0.218487394957983 1.3 1 3 postnatal lethality, incomplete penetrance 1.09135800925616e-13 4.93591463277216e-11 1.74561049671137 0.21830985915493 1.3 1 3 abnormal head morphology 0.0161079911585793 0.137456699852371 1.74458667823823 0.218181818181818 1.3 1 3 abnormal embryo turning 0.0161079911585793 0.137456699852371 1.74458667823823 0.218181818181818 1.3 1 3 abnormal learning/memory/conditioning 0.0161079911585793 0.137456699852371 1.74458667823823 0.218181818181818 1.3 1 3 abnormal liver morphology 2.85401907124795e-05 0.00143421665449077 1.74215010466527 0.217877094972067 1.3 1 3 abnormal inner ear morphology 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 abnormal forelimb morphology 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 delayed wound healing 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 embryonic lethality between implantation and placentation, complete penetrance 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 fragile skeleton 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal blood vessel physiology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal postnatal growth 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal nasal cavity morphology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 dilated heart 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal chondrocyte physiology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal vertebral artery topology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 epidermal hyperplasia 0.0132984577155006 0.12050970334174 1.73247149297269 0.216666666666667 1.3 1 3 absent mesoderm 0.0132984577155006 0.12050970334174 1.73247149297269 0.216666666666667 1.3 1 3 abnormal long bone epiphyseal plate morphology 0.0132984577155006 0.12050970334174 1.73247149297269 0.216666666666667 1.3 1 3 decreased erythrocyte cell number 0.000101782944980864 0.00405096121023838 1.73162265833625 0.21656050955414 1.3 1 3 decreased IgG level 0.0010204466110479 0.0226603945883915 1.72886968113698 0.216216216216216 1.3 1 3 small seminiferous tubules 0.00658581509240532 0.0795253157396031 1.72886968113698 0.216216216216216 1.3 1 3 abnormal vocalization 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 increased insulin secretion 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 abnormal chromosome morphology 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 abnormal hair follicle development 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 abnormal respiratory electron transport chain 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 hyperglycemia 0.0033036857705073 0.0487710288079342 1.72641390033991 0.215909090909091 1.3 1 3 increased liver weight 0.0033036857705073 0.0487710288079342 1.72641390033991 0.215909090909091 1.3 1 3 small lung 0.0224756797611382 0.170192552224753 1.72463225544792 0.215686274509804 1.3 1 3 abnormal lipid homeostasis 0.000436822345755376 0.0127500549424083 1.72222018236338 0.215384615384615 1.3 1 3 abnormal response to infection 0.0054657987315788 0.0688413890876064 1.72066302125817 0.215189873417722 1.3 1 3 abnormal definitive hematopoiesis 0.00274993557209699 0.0428869262419515 1.7195746828513 0.21505376344086 1.3 1 3 polydactyly 0.0022898486318621 0.0379733231450464 1.71343334469826 0.214285714285714 1.3 1 3 reddish skin 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 failure of blastocyst to hatch from the zona pellucida 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 increased triglyceride level 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 abnormal mitotic spindle morphology 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 cleft palate 0.000497512146027563 0.014307068939232 1.70907346341404 0.213740458015267 1.3 1 3 decreased startle reflex 0.000971526916475344 0.0221713138048846 1.70855176821764 0.213675213675214 1.3 1 3 abnormal craniofacial morphology 0.00190741920254648 0.0332577451601639 1.70788825296785 0.213592233009709 1.3 1 3 abnormal muscle physiology 0.00377129249035364 0.0551378911981002 1.70701599134733 0.213483146067416 1.3 1 3 delayed bone ossification 0.00752739420135367 0.0851108776175784 1.70581808538849 0.213333333333333 1.3 1 3 abnormal neurocranium morphology 0.00752739420135367 0.0851108776175784 1.70581808538849 0.213333333333333 1.3 1 3 abnormal cell nucleus morphology 0.0314207799960546 0.216807739917298 1.70128133516139 0.212765957446809 1.3 1 3 abnormal posture 0.00623750653848631 0.0756868171438278 1.69915473349244 0.2125 1.3 1 3 abnormal embryo size 0.00132484668070614 0.0269906800615733 1.69827021775403 0.212389380530973 1.3 1 3 abnormal motor coordination/ balance 0.00260757068615397 0.0413367968673572 1.69612593717606 0.212121212121212 1.3 1 3 dextrocardia 0.0670436765759927 0.335555624713846 1.69612593717606 0.212121212121212 1.3 1 3 decreased brown adipose tissue amount 0.0670436765759927 0.335555624713846 1.69612593717606 0.212121212121212 1.3 1 3 abnormal skin condition 0.0257302071598264 0.188929360558835 1.69146625053546 0.211538461538462 1.3 1 3 atelectasis 0.0103709076280416 0.1095440880032 1.68930048068843 0.211267605633803 1.3 1 3 increased circulating free fatty acid level 0.0103709076280416 0.1095440880032 1.68930048068843 0.211267605633803 1.3 1 3 oxidative stress 0.00429244803718895 0.0593321035056049 1.68804914699903 0.211111111111111 1.3 1 3 abnormal blood homeostasis 0.00150430476451166 0.0284559551461806 1.68337311058075 0.210526315789474 1.3 1 3 abnormal craniofacial bone morphology 0.0211148182447819 0.161128112139528 1.68337311058075 0.210526315789474 1.3 1 3 increased bone marrow cell number 0.0542119415507082 0.30168278435657 1.68337311058075 0.210526315789474 1.3 1 3 impaired branching involved in ureteric bud morphogenesis 0.0542119415507082 0.30168278435657 1.68337311058075 0.210526315789474 1.3 1 3 abnormal retina morphology 2.54212648630399e-05 0.00130547328184691 1.67535704814941 0.20952380952381 1.3 1 3 abnormal organ of Corti morphology 0.0440215426858809 0.26450141891577 1.67358605761226 0.209302325581395 1.3 1 3 abnormal intestinal mucosa morphology 0.0440215426858809 0.26450141891577 1.67358605761226 0.209302325581395 1.3 1 3 postnatal growth retardation 1.11598765065925e-12 4.27079889386907e-10 1.6723706719495 0.209150326797386 1.3 1 3 decreased white adipose tissue amount 0.0142945761659161 0.124748197837098 1.67081062468089 0.208955223880597 1.3 1 3 small spleen 0.00487165095289135 0.064700150217769 1.66949915637266 0.208791208791209 1.3 1 3 abnormal kidney physiology 0.035870183490412 0.224133858141094 1.6658379740122 0.208333333333333 1.3 1 3 abnormal foregut morphology 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal startle reflex 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 blindness 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal sensory capabilities/reflexes/nociception 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal primitive streak formation 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 decreased fatty acid level 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 increased body temperature 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 increased circulating total protein level 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal lung saccule morphology 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 decreased body length 2.2662234412543e-06 0.000170825176064245 1.66340609375817 0.208029197080292 1.3 1 3 obese 0.0097328917644299 0.104807654822595 1.66151112213165 0.207792207792208 1.3 1 3 decreased body weight 9.34166484115476e-24 1.5491594194915e-20 1.65991738670553 0.207592891760905 1.3 1 3 increased circulating bilirubin level 0.0293123322396249 0.204528545430763 1.65955179297819 0.207547169811321 1.3 1 3 abnormal response/metabolism to endogenous compounds 0.00804534103033596 0.0895426658298017 1.65771193511458 0.207317073170732 1.3 1 3 abnormal embryonic neuroepithelium morphology 0.0240117744861625 0.179907497091353 1.65434943626039 0.206896551724138 1.3 1 3 lordosis 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 abnormal circulating glucose level 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 decreased bone strength 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 increased double-positive T cell number 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 decreased body size 1.75574975222368e-15 1.0918568771641e-12 1.65331287646323 0.206766917293233 1.3 1 3 premature death 1.35234376192526e-16 1.12131836926303e-13 1.65306848431594 0.206736353077816 1.3 1 3 cataract 0.00160280863975073 0.0297536305326861 1.65207071802863 0.206611570247934 1.3 1 3 increased circulating insulin level 0.000331716921492571 0.0107123648450191 1.64917959427208 0.20625 1.3 1 3 abnormal myocardial fiber morphology 0.00457029293314017 0.0612862731600333 1.64866438665125 0.206185567010309 1.3 1 3 abnormal vision 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 increased width of hypertrophic chondrocyte zone 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 decreased regulatory T cell number 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 increased susceptibility to weight gain 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 abnormal skin physiology 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 increased susceptibility to viral infection induced morbidity/mortality 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 abnormal coat/hair pigmentation 0.00261424032649568 0.0413367968673572 1.64204028866917 0.205357142857143 1.3 1 3 abnormal brain morphology 0.00037338420556947 0.0111902796548681 1.63893624275486 0.204968944099379 1.3 1 3 muscular atrophy 0.0500910580805625 0.283507410637996 1.63555001084834 0.204545454545455 1.3 1 3 abnormal photoreceptor outer segment morphology 0.0500910580805625 0.283507410637996 1.63555001084834 0.204545454545455 1.3 1 3 decreased macrophage cell number 0.0500910580805625 0.283507410637996 1.63555001084834 0.204545454545455 1.3 1 3 decreased leukocyte cell number 0.00104208484660815 0.022890101757515 1.63422353070978 0.204379562043796 1.3 1 3 decreased circulating creatinine level 0.0407383919332423 0.249905671846955 1.63184128066501 0.204081632653061 1.3 1 3 diluted coat color 0.0332373833869838 0.218035104423838 1.62881935236748 0.203703703703704 1.3 1 3 impaired limb coordination 0.0332373833869838 0.218035104423838 1.62881935236748 0.203703703703704 1.3 1 3 decreased platelet aggregation 0.0332373833869838 0.218035104423838 1.62881935236748 0.203703703703704 1.3 1 3 increased spleen weight 0.00294375203597523 0.0454818831645242 1.62750895868094 0.20353982300885 1.3 1 3 increased B cell proliferation 0.0271899336958866 0.194353333530224 1.62630961530682 0.203389830508475 1.3 1 3 abnormal osteoclast physiology 0.0222934138616507 0.169069716405049 1.62419202466189 0.203125 1.3 1 3 abnormal sternum morphology 0.0183145568919019 0.149111062929718 1.62238133121188 0.202898550724638 1.3 1 3 hyperkeratosis 0.0183145568919019 0.149111062929718 1.62238133121188 0.202898550724638 1.3 1 3 abnormal food intake 0.0183145568919019 0.149111062929718 1.62238133121188 0.202898550724638 1.3 1 3 increased granulocyte number 0.0150715586594716 0.129949747540505 1.62081532606592 0.202702702702703 1.3 1 3 abnormal nervous system morphology 0.0124214447301899 0.11447445765519 1.61944754941945 0.20253164556962 1.3 1 3 impaired glucose tolerance 2.22526897786341e-05 0.00117773544307133 1.6121012651731 0.201612903225806 1.3 1 3 increased tumor incidence 0.00228234212802724 0.0379733231450464 1.6121012651731 0.201612903225806 1.3 1 3 decreased circulating glucose level 8.54887348331604e-06 0.000518666409506065 1.60493637066121 0.200716845878136 1.3 1 3 embryonic lethality, complete penetrance 2.0664422767199e-06 0.000158162312718177 1.60421763516159 0.200626959247649 1.3 1 3 abnormal skeleton morphology 0.00370840918667783 0.0544228191850213 1.59920445505171 0.2 1.3 1 3 abnormal response to new environment 0.108924520463525 0.413872040164636 1.59920445505171 0.2 1.3 1 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00446999278592509 0.0602661628996676 1.59920445505171 0.2 1.3 1 3 decreased monocyte cell number 0.0251191923636393 0.18565539777399 1.59920445505171 0.2 1.3 1 3 increased circulating calcium level 0.0375197314440849 0.231588913069879 1.59920445505171 0.2 1.3 1 3 decreased circulating alkaline phosphatase level 0.0460398385925206 0.275629599275319 1.59920445505171 0.2 1.3 1 3 impaired ovarian folliculogenesis 0.0700801827495195 0.343835216152721 1.59920445505171 0.2 1.3 1 3 abnormal skin pigmentation 0.0700801827495195 0.343835216152721 1.59920445505171 0.2 1.3 1 3 increased susceptibility to weight loss 0.0700801827495195 0.343835216152721 1.59920445505171 0.2 1.3 1 3 abnormal dermal layer morphology 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 increased circulating serum albumin level 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 decreased triglyceride level 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 increased red blood cell distribution width 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 abnormal egg cylinder morphology 0.137438372072013 0.471881229163743 1.59920445505171 0.2 1.3 1 3 abnormal vertebrae development 0.137438372072013 0.471881229163743 1.59920445505171 0.2 1.3 1 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.137438372072013 0.471881229163743 1.59920445505171 0.2 1.3 1 3 abnormal myocardial trabeculae morphology 0.0566856347276413 0.314393570535134 1.59920445505171 0.2 1.3 1 3 lethality at weaning, complete penetrance 0.0566856347276413 0.314393570535134 1.59920445505171 0.2 1.3 1 3 respiratory failure 0.00113951199923461 0.0246021660068254 1.58861369707124 0.198675496688742 1.3 1 3 increased neuron apoptosis 0.0156590688938201 0.134317013356474 1.57946119017453 0.197530864197531 1.3 1 3 abnormal maternal nurturing 0.0344432565989575 0.218565308137517 1.57298798857545 0.19672131147541 1.3 1 3 increased B cell number 0.00463269227004441 0.0619560323749219 1.57186762676023 0.196581196581197 1.3 1 3 impaired balance 0.00814138953595764 0.0904094038870296 1.56784750495266 0.196078431372549 1.3 1 3 abnormal mammary gland development 0.0789715130226143 0.376324978244738 1.56019946834313 0.195121951219512 1.3 1 3 increased bone mineral density 0.00622489217589664 0.0756868171438278 1.55674769960786 0.194690265486726 1.3 1 3 abnormal trophoblast giant cell morphology 0.0982443862861583 0.413872040164636 1.55478210907805 0.194444444444444 1.3 1 3 weight loss 0.000844044443958771 0.0200914885583487 1.55351289919309 0.194285714285714 1.3 1 3 abnormal cranium morphology 0.00328762911278358 0.0487710288079342 1.55146700863226 0.194029850746269 1.3 1 3 abnormal postnatal growth/weight/body size 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 abnormal nose morphology 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 decreased neuronal precursor cell number 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 decreased double-negative T cell number 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 small cranium 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 abnormal intestine physiology 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 increased circulating triglyceride level 0.00252469819288177 0.0406484579598279 1.54405947384303 0.193103448275862 1.3 1 3 decreased birth body size 0.00692251308377558 0.081804044161006 1.54309201803235 0.192982456140351 1.3 1 3 short tail 0.0195131521936394 0.155978669900868 1.54140188438719 0.192771084337349 1.3 1 3 abnormal vertebrae morphology 0.00835373150458969 0.0921503641581679 1.54051805303146 0.192660550458716 1.3 1 3 cachexia 0.0100893931918401 0.107946503509852 1.53769659139588 0.192307692307692 1.3 1 3 decreased IgA level 0.0579912389872498 0.319087932490433 1.53769659139588 0.192307692307692 1.3 1 3 abnormal female meiosis 0.0579912389872498 0.319087932490433 1.53769659139588 0.192307692307692 1.3 1 3 increased percent body fat/body weight 0.0579912389872498 0.319087932490433 1.53769659139588 0.192307692307692 1.3 1 3 ventricular hypoplasia 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 abnormal Schwann cell morphology 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 increased susceptibility to otitis media 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 increased thymocyte apoptosis 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 increased embryonic tissue cell apoptosis 0.0237071048371286 0.177935050790243 1.53769659139588 0.192307692307692 1.3 1 3 embryonic lethality before implantation, complete penetrance 0.00528881353787173 0.0669127545739668 1.53523627684964 0.192 1.3 1 3 increased body weight 0.000251077396906915 0.00861455206628896 1.53495070462553 0.191964285714286 1.3 1 3 increased mean corpuscular hemoglobin 0.0121970359580733 0.114449888811311 1.53459013363548 0.191919191919192 1.3 1 3 abnormal fertility/fecundity 0.0288496216036313 0.20395347353213 1.53348372402219 0.191780821917808 1.3 1 3 cleft secondary palate 0.0147601478872512 0.12815311647308 1.53115320164525 0.191489361702128 1.3 1 3 abnormal T-helper 1 physiology 0.0714878831800909 0.350396274700446 1.53115320164525 0.191489361702128 1.3 1 3 decreased circulating alanine transaminase level 0.0351731383879514 0.221782463219339 1.52865131732884 0.191176470588235 1.3 1 3 enlarged spleen 4.4146395129911e-05 0.00205260108197483 1.52701814284452 0.190972222222222 1.3 1 3 abnormal cartilage morphology 0.0885026518210486 0.41380847889257 1.52305186195401 0.19047619047619 1.3 1 3 gliosis 0.0429746319549827 0.259464555796163 1.52305186195401 0.19047619047619 1.3 1 3 increased or absent threshold for auditory brainstem response 4.87073104212835e-05 0.00218305287698996 1.52173434304228 0.190311418685121 1.3 1 3 increased sensitivity to induced morbidity/mortality 0.00105841092288009 0.0230947120233703 1.52098249801114 0.190217391304348 1.3 1 3 abnormal visceral yolk sac morphology 0.0263521814246925 0.189393521964911 1.51823207758074 0.189873417721519 1.3 1 3 reduced male fertility 0.00033805854887799 0.0107123648450191 1.51466501249391 0.18942731277533 1.3 1 3 abnormal long bone metaphysis morphology 0.110149540927394 0.413872040164636 1.51276097099486 0.189189189189189 1.3 1 3 increased erythroid progenitor cell number 0.110149540927394 0.413872040164636 1.51276097099486 0.189189189189189 1.3 1 3 no abnormal phenotype detected 7.08466746336717e-23 8.81155515756291e-20 1.51163994598548 0.189048991354467 1.3 1 3 enlarged kidney 0.0646607521843717 0.325847486475279 1.50868344816199 0.188679245283019 1.3 1 3 decreased spleen weight 0.03908673766382 0.240664009749387 1.50649695041103 0.188405797101449 1.3 1 3 perimembraneous ventricular septal defect 0.03908673766382 0.240664009749387 1.50649695041103 0.188405797101449 1.3 1 3 cardiac fibrosis 0.0240512118022309 0.179931998069322 1.50513360475455 0.188235294117647 1.3 1 3 abnormal osteoclast morphology 0.0797073523392473 0.378743149845038 1.49925417661098 0.1875 1.3 1 3 abnormal tooth morphology 0.0477472207457514 0.279983351516511 1.49925417661098 0.1875 1.3 1 3 abnormal serotonin level 0.138022236680589 0.473232686068871 1.49925417661098 0.1875 1.3 1 3 abnormal glucose homeostasis 0.00169832972658917 0.0310631999624306 1.49376240307028 0.186813186813187 1.3 1 3 kinked tail 0.0165425452519959 0.140203002774582 1.48945512970502 0.186274509803922 1.3 1 3 increased neutrophil cell number 0.004999908187877 0.064700150217769 1.48891449263435 0.186206896551724 1.3 1 3 hyperactivity 1.29595046149037e-05 0.000742744783647047 1.48713082747396 0.185983827493261 1.3 1 3 increased exploration in new environment 0.0322900039365085 0.218035104423838 1.48074486578862 0.185185185185185 1.3 1 3 abnormal chondrocyte morphology 0.0718024269110509 0.350637256540451 1.48074486578862 0.185185185185185 1.3 1 3 abnormal mandible morphology 0.0718024269110509 0.350637256540451 1.48074486578862 0.185185185185185 1.3 1 3 abnormal palate morphology 0.174504670241885 0.56188947043965 1.48074486578862 0.185185185185185 1.3 1 3 abnormal skin appearance 0.174504670241885 0.56188947043965 1.48074486578862 0.185185185185185 1.3 1 3 abnormal bone trabecula morphology 0.174504670241885 0.56188947043965 1.48074486578862 0.185185185185185 1.3 1 3 abnormal compact bone morphology 0.122780611754388 0.442324170051644 1.47295147175815 0.184210526315789 1.3 1 3 improved glucose tolerance 0.00172384704294927 0.0314144287130865 1.46865715259851 0.183673469387755 1.3 1 3 increased circulating LDL cholesterol level 0.0884753684305987 0.41380847889257 1.46865715259851 0.183673469387755 1.3 1 3 absent kidney 0.0884753684305987 0.41380847889257 1.46865715259851 0.183673469387755 1.3 1 3 increased bone mineral content 0.0166149026685474 0.140576770027251 1.46716005050616 0.18348623853211 1.3 1 3 abnormal behavior 0.000229620584629669 0.00804480569389157 1.46689617279923 0.183453237410072 1.3 1 3 abnormal kidney development 0.0647110184196132 0.325847486475279 1.46593741713073 0.183333333333333 1.3 1 3 ataxia 0.00157995903035703 0.0294393115206974 1.46461794150775 0.183168316831683 1.3 1 3 decreased liver weight 0.0478171407384199 0.279983351516511 1.46406041659664 0.183098591549296 1.3 1 3 abnormal testis morphology 0.0151392068223035 0.130082131158825 1.46014319809069 0.182608695652174 1.3 1 3 abnormal nervous system physiology 0.0151392068223035 0.130082131158825 1.46014319809069 0.182608695652174 1.3 1 3 decreased circulating calcium level 0.0794208036814877 0.377742350205929 1.45382223186519 0.181818181818182 1.3 1 3 abnormal T-helper 2 physiology 0.0794208036814877 0.377742350205929 1.45382223186519 0.181818181818182 1.3 1 3 hypertension 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 abnormal astrocyte morphology 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 renal interstitial fibrosis 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 embryonic lethality, incomplete penetrance 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 decreased systemic arterial blood pressure 0.153795250037166 0.511109798887711 1.45382223186519 0.181818181818182 1.3 1 3 abnormal QRS complex 0.153795250037166 0.511109798887711 1.45382223186519 0.181818181818182 1.3 1 3 cardiovascular system phenotype 0.153795250037166 0.511109798887711 1.45382223186519 0.181818181818182 1.3 1 3 limb grasping 0.0032239611928778 0.0480215776484043 1.44982821474468 0.181318681318681 1.3 1 3 small testis 0.000356689192172099 0.0108934676806607 1.44855476001061 0.181159420289855 1.3 1 3 spleen hypoplasia 0.0220089963658229 0.167167567816746 1.44689926885631 0.180952380952381 1.3 1 3 postnatal lethality 0.0050472737772255 0.0647169769115898 1.44506426661299 0.180722891566265 1.3 1 3 abnormal neural tube closure 0.0391487152247252 0.24074766161064 1.44506426661299 0.180722891566265 1.3 1 3 abnormal forebrain development 0.0526513265403818 0.293655100379372 1.44372624414391 0.180555555555556 1.3 1 3 decreased bone mineral density 0.000505414563447433 0.0144507899606378 1.44289123764064 0.180451127819549 1.3 1 3 abnormal hepatocyte morphology 0.0200011734825394 0.158955012900373 1.44072473428082 0.18018018018018 1.3 1 3 abnormal hindlimb morphology 0.0977904847365182 0.413872040164636 1.43928400954654 0.18 1.3 1 3 kidney inflammation 0.0977904847365182 0.413872040164636 1.43928400954654 0.18 1.3 1 3 increased circulating chloride level 0.0977904847365182 0.413872040164636 1.43928400954654 0.18 1.3 1 3 increased rib number 0.0475360274303369 0.279983351516511 1.43518348530282 0.179487179487179 1.3 1 3 small lens 0.136113900563858 0.471216150871718 1.43518348530282 0.179487179487179 1.3 1 3 abnormal iris morphology 0.136113900563858 0.471216150871718 1.43518348530282 0.179487179487179 1.3 1 3 abnormal response to injury 0.136113900563858 0.471216150871718 1.43518348530282 0.179487179487179 1.3 1 3 decreased compact bone thickness 0.0642012503572381 0.323936329135152 1.43212339258362 0.17910447761194 1.3 1 3 maternal effect 0.0642012503572381 0.323936329135152 1.43212339258362 0.17910447761194 1.3 1 3 increased food intake 0.0429435454845864 0.259464555796163 1.42786112058188 0.178571428571429 1.3 1 3 abnormal eye development 0.0875182268921685 0.411145589035447 1.42786112058188 0.178571428571429 1.3 1 3 shortened head 0.194320298698717 0.581941394461375 1.42786112058188 0.178571428571429 1.3 1 3 increased bone resorption 0.194320298698717 0.581941394461375 1.42786112058188 0.178571428571429 1.3 1 3 prolonged QRS complex duration 0.194320298698717 0.581941394461375 1.42786112058188 0.178571428571429 1.3 1 3 abnormal T cell differentiation 0.0290810955757738 0.20395347353213 1.42503367281836 0.178217821782178 1.3 1 3 abnormal pulmonary alveolus morphology 0.0290810955757738 0.20395347353213 1.42503367281836 0.178217821782178 1.3 1 3 astrocytosis 0.0578083626100111 0.319087932490433 1.42394917230632 0.178082191780822 1.3 1 3 decreased percent body fat/body weight 0.0578083626100111 0.319087932490433 1.42394917230632 0.178082191780822 1.3 1 3 increased T cell proliferation 0.026357338492912 0.189393521964911 1.41985442270946 0.177570093457944 1.3 1 3 increased circulating glucose level 0.012425368268101 0.11447445765519 1.41773444596783 0.177304964539007 1.3 1 3 hunched posture 0.0520987019546297 0.290899037288757 1.41701660574202 0.177215189873418 1.3 1 3 abnormal spleen red pulp morphology 0.170319724942586 0.555269090163411 1.41106275445739 0.176470588235294 1.3 1 3 abnormal bone structure 0.00452374866512827 0.0608260800243598 1.40862568579684 0.176165803108808 1.3 1 3 abnormal B cell differentiation 0.0424181404566693 0.257353961916988 1.40589402641909 0.175824175824176 1.3 1 3 decreased brain weight 0.0960948226078394 0.413872040164636 1.40281092548396 0.175438596491228 1.3 1 3 increased hepatocellular carcinoma incidence 0.0960948226078394 0.413872040164636 1.40281092548396 0.175438596491228 1.3 1 3 perinatal lethality 0.150121052827506 0.505654866497523 1.39930389817025 0.175 1.3 1 3 abnormal pancreatic beta cell morphology 0.150121052827506 0.505654866497523 1.39930389817025 0.175 1.3 1 3 abnormal hair follicle morphology 0.0859545864880214 0.405715434324389 1.39613087345784 0.174603174603175 1.3 1 3 abnormal epidermal layer morphology 0.077018364780968 0.367369477263007 1.39061256961018 0.173913043478261 1.3 1 3 abnormal coat appearance 0.077018364780968 0.367369477263007 1.39061256961018 0.173913043478261 1.3 1 3 abnormal spermatogenesis 0.0069681912412597 0.0821487000598744 1.39061256961018 0.173913043478261 1.3 1 3 abnormal locomotor behavior 0.046251179763504 0.276562042456048 1.39061256961018 0.173913043478261 1.3 1 3 postnatal lethality, complete penetrance 0.000151453261889194 0.00553676420446608 1.38791060218218 0.173575129533679 1.3 1 3 abnormal leukocyte migration 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 decreased kidney weight 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 increased susceptibility to injury 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 decreased body temperature 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 abnormal spleen morphology 0.00988287105500891 0.106192836930171 1.37862453021699 0.172413793103448 1.3 1 3 short limbs 0.0558757803414409 0.310594421451026 1.37862453021699 0.172413793103448 1.3 1 3 absent long term depression 0.214869990883785 0.589867840222085 1.37862453021699 0.172413793103448 1.3 1 3 short sternum 0.214869990883785 0.589867840222085 1.37862453021699 0.172413793103448 1.3 1 3 abnormal CD8-positive, alpha-beta T cell physiology 0.214869990883785 0.589867840222085 1.37862453021699 0.172413793103448 1.3 1 3 abnormal enzyme/coenzyme activity 0.0142710943118477 0.124748197837098 1.37511211103173 0.171974522292994 1.3 1 3 abnormal lens morphology 0.0252219821628342 0.18565539777399 1.37431632856006 0.171875 1.3 1 3 abnormal humoral immune response 0.0409300683468303 0.250463825369595 1.37074667575861 0.171428571428571 1.3 1 3 domed cranium 0.0839949143644411 0.396842069290688 1.37074667575861 0.171428571428571 1.3 1 3 dehydration 0.0839949143644411 0.396842069290688 1.37074667575861 0.171428571428571 1.3 1 3 increased carcinoma incidence 0.187540951244593 0.581941394461375 1.37074667575861 0.171428571428571 1.3 1 3 abnormal intestinal goblet cell morphology 0.187540951244593 0.581941394461375 1.37074667575861 0.171428571428571 1.3 1 3 holoprosencephaly 0.187540951244593 0.581941394461375 1.37074667575861 0.171428571428571 1.3 1 3 neonatal lethality, complete penetrance 7.60026312784855e-05 0.00318130418065858 1.36774065234686 0.171052631578947 1.3 1 3 decreased anxiety-related response 0.0301954368828868 0.208642081239391 1.36517453480024 0.170731707317073 1.3 1 3 Leydig cell hyperplasia 0.164769487493219 0.54394704729845 1.36517453480024 0.170731707317073 1.3 1 3 arrested B cell differentiation 0.164769487493219 0.54394704729845 1.36517453480024 0.170731707317073 1.3 1 3 increased cellular sensitivity to gamma-irradiation 0.145484948475002 0.490703470280091 1.36102506812912 0.170212765957447 1.3 1 3 abnormal innervation 0.145484948475002 0.490703470280091 1.36102506812912 0.170212765957447 1.3 1 3 increased systemic arterial blood pressure 0.145484948475002 0.490703470280091 1.36102506812912 0.170212765957447 1.3 1 3 increased monocyte cell number 0.0492144582115907 0.283507410637996 1.35932378679395 0.17 1.3 1 3 azoospermia 0.0166846820313634 0.140927492539954 1.35781510334579 0.169811320754717 1.3 1 3 abnormal mesoderm development 0.128960503557935 0.462565612978175 1.35781510334579 0.169811320754717 1.3 1 3 abnormal pancreatic islet morphology 0.128960503557935 0.462565612978175 1.35781510334579 0.169811320754717 1.3 1 3 reduced long term potentiation 0.0400378491554206 0.245911480923725 1.35646806455279 0.169642857142857 1.3 1 3 abnormal colon morphology 0.114674956863473 0.418807609008169 1.35525801275569 0.169491525423729 1.3 1 3 abnormal ovary morphology 0.0913531056104115 0.413872040164636 1.35144038455074 0.169014084507042 1.3 1 3 abnormal cytokine secretion 0.0198631751630906 0.158110874298201 1.34997778673196 0.168831168831169 1.3 1 3 increased startle reflex 0.0658477404648397 0.330901524053109 1.34764420369526 0.168539325842697 1.3 1 3 decreased rib number 0.0658477404648397 0.330901524053109 1.34764420369526 0.168539325842697 1.3 1 3 decreased bone mineral content 0.00832028141497861 0.0919853334211525 1.34548451747139 0.168269230769231 1.3 1 3 decreased litter size 0.00288728555473466 0.0447484287688626 1.33741297842403 0.167259786476868 1.3 1 3 male infertility 9.68347929040646e-05 0.00388510560240098 1.33531982330361 0.166998011928429 1.3 1 3 abnormal digit morphology 0.0990934614244177 0.413872040164636 1.33267037920976 0.166666666666667 1.3 1 3 abnormal tail morphology 0.111016340240255 0.413872040164636 1.33267037920976 0.166666666666667 1.3 1 3 abnormal small intestine morphology 0.140392118887312 0.476202746492064 1.33267037920976 0.166666666666667 1.3 1 3 neurodegeneration 0.140392118887312 0.476202746492064 1.33267037920976 0.166666666666667 1.3 1 3 abnormal cardiovascular system morphology 0.158640467702153 0.525107336539062 1.33267037920976 0.166666666666667 1.3 1 3 thymus atrophy 0.158640467702153 0.525107336539062 1.33267037920976 0.166666666666667 1.3 1 3 abnormal reproductive system morphology 0.180022854627653 0.567922448809495 1.33267037920976 0.166666666666667 1.3 1 3 heart right ventricle hypertrophy 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 abnormal uterus morphology 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 reduced long term depression 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 abnormal limb bone morphology 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 narrow eye opening 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 abnormal hair cycle 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 emphysema 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal pain threshold 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 enhanced paired-pulse facilitation 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal synaptic transmission 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal microglial cell physiology 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal bone mineralization 0.0454457930205245 0.272729578138853 1.3216565744229 0.165289256198347 1.3 1 3 increased circulating cholesterol level 0.0198326576599973 0.158110874298201 1.31752639762783 0.164772727272727 1.3 1 3 abnormal contextual conditioning behavior 0.152321289253669 0.510527644832276 1.30844000867867 0.163636363636364 1.3 1 3 abnormal long bone hypertrophic chondrocyte zone 0.172331218779529 0.561091500934658 1.30547302453201 0.163265306122449 1.3 1 3 increased T cell derived lymphoma incidence 0.172331218779529 0.561091500934658 1.30547302453201 0.163265306122449 1.3 1 3 abnormal male reproductive system morphology 0.195841511434041 0.581941394461375 1.30167804480953 0.162790697674419 1.3 1 3 decreased oxygen consumption 0.195841511434041 0.581941394461375 1.30167804480953 0.162790697674419 1.3 1 3 increased brown adipose tissue amount 0.223835888102516 0.59422814477589 1.29665226085274 0.162162162162162 1.3 1 3 decreased circulating chloride level 0.223835888102516 0.59422814477589 1.29665226085274 0.162162162162162 1.3 1 3 decreased width of hypertrophic chondrocyte zone 0.223835888102516 0.59422814477589 1.29665226085274 0.162162162162162 1.3 1 3 lung inflammation 0.0458777798155944 0.274990306726003 1.29347419158594 0.161764705882353 1.3 1 3 female infertility 0.00776174600457986 0.0875616471038204 1.29259006705307 0.161654135338346 1.3 1 3 hypoglycemia 0.0891940008470494 0.41380847889257 1.28968101213848 0.161290322580645 1.3 1 3 lethargy 0.0891940008470494 0.41380847889257 1.28968101213848 0.161290322580645 1.3 1 3 abnormal cranial ganglia morphology 0.257791489156608 0.66128634260312 1.28968101213848 0.161290322580645 1.3 1 3 abnormal retinal photoreceptor layer morphology 0.257791489156608 0.66128634260312 1.28968101213848 0.161290322580645 1.3 1 3 short mandible 0.164730386301616 0.54394704729845 1.2850750085237 0.160714285714286 1.3 1 3 abnormal trabecular bone morphology 0.0669676762828735 0.335555624713846 1.27667582546145 0.159663865546218 1.3 1 3 hypoactivity 0.00281364325493963 0.0437433599791395 1.27257648943107 0.159151193633952 1.3 1 3 osteoporosis 0.212183007897923 0.587363843684855 1.27209445288204 0.159090909090909 1.3 1 3 cochlear hair cell degeneration 0.212183007897923 0.587363843684855 1.27209445288204 0.159090909090909 1.3 1 3 impaired coordination 0.00419321593405263 0.0584348719101172 1.27104400329254 0.158959537572254 1.3 1 3 abnormal developmental patterning 0.119485930751936 0.434533995241874 1.26766206802879 0.158536585365854 1.3 1 3 abnormal frontal bone morphology 0.24278375241779 0.636044849014484 1.26252983293556 0.157894736842105 1.3 1 3 decreased threshold for auditory brainstem response 0.24278375241779 0.636044849014484 1.26252983293556 0.157894736842105 1.3 1 3 thick epidermis 0.150246033098772 0.505733433468464 1.25651778611206 0.157142857142857 1.3 1 3 increased total body fat amount 0.0663453760829795 0.333065838559862 1.25310796851067 0.156716417910448 1.3 1 3 decreased lymphocyte cell number 0.0735492585884066 0.358030882071745 1.24937848050915 0.15625 1.3 1 3 increased circulating follicle stimulating hormone level 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 neonatal lethality 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 abnormal lumbar vertebrae morphology 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 decreased susceptibility to parasitic infection 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 abnormal auditory brainstem response waveform shape 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 abnormal autopod morphology 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 increased circulating corticosterone level 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 abnormal metabolism 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 cardiomyopathy 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 abnormal gait 0.0107623100922438 0.111779734256603 1.24210054761298 0.155339805825243 1.3 1 3 decreased grip strength 0.0282285844978211 0.200338384988102 1.2413915861132 0.155251141552511 1.3 1 3 decreased exploration in new environment 0.136965370037397 0.471232860260062 1.23747963783763 0.154761904761905 1.3 1 3 decreased neutrophil cell number 0.0965035779949803 0.413872040164636 1.2301572731167 0.153846153846154 1.3 1 3 increased circulating alanine transaminase level 0.15341662577057 0.510875310045909 1.2301572731167 0.153846153846154 1.3 1 3 absent gastric milk in neonates 0.15341662577057 0.510875310045909 1.2301572731167 0.153846153846154 1.3 1 3 kinked neural tube 0.216325617336884 0.589867840222085 1.2301572731167 0.153846153846154 1.3 1 3 acanthosis 0.262178270936687 0.66128634260312 1.2301572731167 0.153846153846154 1.3 1 3 impaired macrophage chemotaxis 0.262178270936687 0.66128634260312 1.2301572731167 0.153846153846154 1.3 1 3 abnormal spatial learning 0.0602166554320522 0.321548796131559 1.22638378454886 0.153374233128834 1.3 1 3 abnormal thoracic vertebrae morphology 0.204628639766255 0.581941394461375 1.21973221148012 0.152542372881356 1.3 1 3 abnormal immune system morphology 0.246253602206476 0.64411759777982 1.21678599840891 0.152173913043478 1.3 1 3 abnormal lymphocyte physiology 0.246253602206476 0.64411759777982 1.21678599840891 0.152173913043478 1.3 1 3 decreased food intake 0.163731607304206 0.541598900490973 1.21458566206459 0.151898734177215 1.3 1 3 increased cardiomyocyte apoptosis 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal locomotor coordination 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal T cell subpopulation ratio 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 increased osteoblast cell number 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal middle ear ossicle morphology 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal placenta development 0.231857193119808 0.610635010995789 1.20694675852959 0.150943396226415 1.3 1 3 increased erythrocyte cell number 0.218739385980492 0.589867840222085 1.19940334128878 0.15 1.3 1 3 abnormal female reproductive system morphology 0.281953074132424 0.686522919928321 1.19940334128878 0.15 1.3 1 3 abnormal dendritic cell physiology 0.134581893722072 0.471216150871718 1.19566688228165 0.149532710280374 1.3 1 3 seizures 0.128312673021618 0.460906533055993 1.19238928666136 0.149122807017544 1.3 1 3 pulmonary hypoplasia 0.263888116609484 0.66128634260312 1.19089693461298 0.148936170212766 1.3 1 3 abnormal osteoblast physiology 0.247764162551546 0.64480380668358 1.1845958926309 0.148148148148148 1.3 1 3 axon degeneration 0.247764162551546 0.64480380668358 1.1845958926309 0.148148148148148 1.3 1 3 abnormal long bone morphology 0.233212266729993 0.613554218393293 1.17974099143159 0.147540983606557 1.3 1 3 increased double-negative T cell number 0.233212266729993 0.613554218393293 1.17974099143159 0.147540983606557 1.3 1 3 impaired righting response 0.166949489385133 0.550676607242655 1.17836117740652 0.147368421052632 1.3 1 3 decreased susceptibility to injury 0.219967933587516 0.589867840222085 1.17588562871449 0.147058823529412 1.3 1 3 abnormal oocyte morphology 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 abnormal endoderm development 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 impaired synaptic plasticity 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 abnormal bone remodeling 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 decreased osteoblast cell number 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 abnormal cholesterol homeostasis 0.30204168898486 0.691801147065167 1.17014960125735 0.146341463414634 1.3 1 3 abnormal intestinal epithelium morphology 0.281857227398541 0.686522919928321 1.16608658180854 0.145833333333333 1.3 1 3 abnormal hair shaft morphology 0.281857227398541 0.686522919928321 1.16608658180854 0.145833333333333 1.3 1 3 abnormal axial skeleton morphology 0.220355767667274 0.589867840222085 1.15731901352426 0.144736842105263 1.3 1 3 abnormal lipid level 0.208250753202523 0.581941394461375 1.15605141329039 0.144578313253012 1.3 1 3 decreased insulin secretion 0.197089155704347 0.581941394461375 1.15498099531512 0.144444444444444 1.3 1 3 increased susceptibility to parasitic infection 0.197089155704347 0.581941394461375 1.15498099531512 0.144444444444444 1.3 1 3 decreased IgM level 0.186754624297459 0.581941394461375 1.15406507065587 0.144329896907216 1.3 1 3 increased anxiety-related response 0.137761271314918 0.47266367227015 1.15050680219548 0.143884892086331 1.3 1 3 arrest of spermatogenesis 0.22013165039671 0.589867840222085 1.14228889646551 0.142857142857143 1.3 1 3 abnormal nervous system electrophysiology 0.22013165039671 0.589867840222085 1.14228889646551 0.142857142857143 1.3 1 3 organ of Corti degeneration 0.300111562168376 0.690589741807432 1.14228889646551 0.142857142857143 1.3 1 3 abnormal respiratory system physiology 0.300111562168376 0.690589741807432 1.14228889646551 0.142857142857143 1.3 1 3 decreased urine osmolality 0.300111562168376 0.690589741807432 1.14228889646551 0.142857142857143 1.3 1 3 abnormal vibrissa morphology 0.322378161377728 0.721488848426874 1.14228889646551 0.142857142857143 1.3 1 3 spina bifida 0.322378161377728 0.721488848426874 1.14228889646551 0.142857142857143 1.3 1 3 impaired fertilization 0.247433717398605 0.64480380668358 1.14228889646551 0.142857142857143 1.3 1 3 skin lesions 0.263130979181409 0.66128634260312 1.14228889646551 0.142857142857143 1.3 1 3 increased circulating aspartate transaminase level 0.263130979181409 0.66128634260312 1.14228889646551 0.142857142857143 1.3 1 3 enhanced long term potentiation 0.280556319957319 0.686522919928321 1.14228889646551 0.142857142857143 1.3 1 3 decreased circulating thyroxine level 0.348251056920452 0.768658249632144 1.14228889646551 0.142857142857143 1.3 1 3 abnormal eye electrophysiology 0.185958458884991 0.581941394461375 1.12340808825947 0.140495867768595 1.3 1 3 decreased susceptibility to induced arthritis 0.297365587788032 0.686522919928321 1.12224874038717 0.140350877192982 1.3 1 3 infertility 0.206796944127528 0.581941394461375 1.12093770213905 0.14018691588785 1.3 1 3 enlarged liver 0.218432456344365 0.589867840222085 1.1194431185362 0.14 1.3 1 3 testicular atrophy 0.318601672827242 0.715918393096445 1.1194431185362 0.14 1.3 1 3 increased circulating creatinine level 0.244692585277558 0.640708216713605 1.11572403840817 0.13953488372093 1.3 1 3 abnormal blood circulation 0.342897618125353 0.761569486684656 1.11572403840817 0.13953488372093 1.3 1 3 dermatitis 0.314398979189821 0.706793909385161 1.10289962417359 0.137931034482759 1.3 1 3 thrombocytosis 0.314398979189821 0.706793909385161 1.10289962417359 0.137931034482759 1.3 1 3 abnormal cued conditioning behavior 0.337278414439824 0.749423899883039 1.09749325346686 0.137254901960784 1.3 1 3 abnormal response to novel object 0.337278414439824 0.749423899883039 1.09749325346686 0.137254901960784 1.3 1 3 abnormal immune system physiology 0.214032803339765 0.589867840222085 1.0962288603177 0.137096774193548 1.3 1 3 abnormal seminiferous tubule morphology 0.191477077095028 0.581941394461375 1.09534551715871 0.136986301369863 1.3 1 3 abnormal motor capabilities/coordination/movement 0.212277425315652 0.587363843684855 1.09036667389889 0.136363636363636 1.3 1 3 increased T cell number 0.270210126892856 0.676204920166981 1.09036667389889 0.136363636363636 1.3 1 3 teratozoospermia 0.270210126892856 0.676204920166981 1.09036667389889 0.136363636363636 1.3 1 3 abnormal skin morphology 0.309993223922854 0.697519805072907 1.09036667389889 0.136363636363636 1.3 1 3 abnormal myelopoiesis 0.363536767108631 0.777499907058603 1.09036667389889 0.136363636363636 1.3 1 3 abnormal amino acid level 0.363536767108631 0.777499907058603 1.09036667389889 0.136363636363636 1.3 1 3 abnormal branching of the mammary ductal tree 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 impaired skeletal muscle contractility 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 abnormal calcium ion homeostasis 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 abnormal humerus morphology 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 increased trabecular bone volume 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 absent corpus luteum 0.35609329398917 0.775980787383321 1.07638761397711 0.134615384615385 1.3 1 3 abnormal neuron differentiation 0.260671035080059 0.66128634260312 1.07089584043641 0.133928571428571 1.3 1 3 altered response to myocardial infarction 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 abnormal ovarian follicle morphology 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 irregular heartbeat 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 decreased osteoclast cell number 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 decreased hair follicle number 0.41729321989823 0.843230612913767 1.05210819411297 0.131578947368421 1.3 1 3 abnormal retinal outer nuclear layer morphology 0.41729321989823 0.843230612913767 1.05210819411297 0.131578947368421 1.3 1 3 abnormal CNS synaptic transmission 0.304911911710817 0.691801147065167 1.04998272301375 0.131313131313131 1.3 1 3 increased osteoclast cell number 0.366458718977974 0.777499907058603 1.0486586590503 0.131147540983607 1.3 1 3 abnormal male meiosis 0.366458718977974 0.777499907058603 1.0486586590503 0.131147540983607 1.3 1 3 abnormal NK cell physiology 0.366458718977974 0.777499907058603 1.0486586590503 0.131147540983607 1.3 1 3 decreased inflammatory response 0.32950464133908 0.73280536015285 1.04709815509338 0.130952380952381 1.3 1 3 hydroencephaly 0.295213762837809 0.686522919928321 1.04295942720764 0.130434782608696 1.3 1 3 abnormal cochlea morphology 0.393948625372859 0.799754974769717 1.03652140605203 0.12962962962963 1.3 1 3 polyphagia 0.393948625372859 0.799754974769717 1.03652140605203 0.12962962962963 1.3 1 3 abnormal excitatory postsynaptic currents 0.366420430341547 0.777499907058603 1.02513106093058 0.128205128205128 1.3 1 3 abnormal lens fiber morphology 0.440104241804339 0.853929474613872 1.02513106093058 0.128205128205128 1.3 1 3 decreased B-1 B cell number 0.440104241804339 0.853929474613872 1.02513106093058 0.128205128205128 1.3 1 3 neuron degeneration 0.425571932333486 0.853929474613872 1.02076880109684 0.127659574468085 1.3 1 3 decreased bone trabecula number 0.425571932333486 0.853929474613872 1.02076880109684 0.127659574468085 1.3 1 3 abnormal joint morphology 0.412898043530453 0.835188232426901 1.01767556230563 0.127272727272727 1.3 1 3 increased susceptibility to pharmacologically induced seizures 0.378979357544616 0.782199824502399 0.999502784407319 0.125 1.3 1 3 abnormal urine homeostasis 0.378979357544616 0.782199824502399 0.999502784407319 0.125 1.3 1 3 abnormal inflammatory response 0.407797915924736 0.825384309082817 0.999502784407319 0.125 1.3 1 3 cochlear outer hair cell degeneration 0.407797915924736 0.825384309082817 0.999502784407319 0.125 1.3 1 3 decreased eosinophil cell number 0.419168372339136 0.845645844439255 0.999502784407319 0.125 1.3 1 3 oligodactyly 0.44610260446705 0.854915430363473 0.999502784407319 0.125 1.3 1 3 abnormal phalanx morphology 0.44610260446705 0.854915430363473 0.999502784407319 0.125 1.3 1 3 head bobbing 0.462697265757469 0.880274912865549 0.999502784407319 0.125 1.3 1 3 abnormal skeleton development 0.412977497843251 0.835188232426901 0.98716324385908 0.123456790123457 1.3 1 3 impaired natural killer cell mediated cytotoxicity 0.450625382316301 0.858950680851953 0.98196764783877 0.12280701754386 1.3 1 3 abnormal circulating amino acid level 0.450625382316301 0.858950680851953 0.98196764783877 0.12280701754386 1.3 1 3 increased tumor growth/size 0.485010540309221 0.912259900959687 0.975124667714458 0.121951219512195 1.3 1 3 palatal shelves fail to meet at midline 0.485010540309221 0.912259900959687 0.975124667714458 0.121951219512195 1.3 1 3 abnormal T cell activation 0.440714946434184 0.853929474613872 0.972489195639554 0.121621621621622 1.3 1 3 impaired swimming 0.454193842732752 0.865421052315374 0.969214821243461 0.121212121212121 1.3 1 3 deafness 0.421191242882331 0.849382421296959 0.969214821243461 0.121212121212121 1.3 1 3 small ovary 0.432152152082364 0.853929474613872 0.966552143163122 0.120879120879121 1.3 1 3 abnormal spermiogenesis 0.469323123921897 0.891734259239537 0.965037171151894 0.120689655172414 1.3 1 3 abnormal optic nerve morphology 0.506987888813477 0.920132028117216 0.951907413721256 0.119047619047619 1.3 1 3 increased hemoglobin content 0.487860371531864 0.91727337428988 0.948680608928981 0.11864406779661 1.3 1 3 circling 0.474945758394673 0.897741317634308 0.940708502971594 0.117647058823529 1.3 1 3 retinal degeneration 0.505300613847409 0.920132028117216 0.916210885706709 0.114583333333333 1.3 1 3 increased circulating HDL cholesterol level 0.505150064726274 0.920132028117216 0.913831117172406 0.114285714285714 1.3 1 3 abnormal action potential 0.52282372221628 0.944804946613147 0.913831117172406 0.114285714285714 1.3 1 3 increased eosinophil cell number 0.542175421340653 0.974599446258516 0.902776708496933 0.112903225806452 1.3 1 3 abnormal locomotor activation 0.56482255680575 0.985962182494248 0.878683766511929 0.10989010989011 1.3 1 3 abnormal excitatory postsynaptic potential 0.568204708709393 0.991518213198607 0.877612200943012 0.109756097560976 1.3 1 3 decreased caudal vertebrae number 0.577013252840266 1 0.874564936356404 0.109375 1.3 1 3 abnormal sleep pattern 0.590608137316972 1 0.869132856006364 0.108695652173913 1.3 1 3 abnormal enzyme/coenzyme level 0.636064804548489 1 0.827174718130195 0.103448275862069 1.3 1 3 abnormal inhibitory postsynaptic currents 0.642563967531141 1 0.823119940100145 0.102941176470588 1.3 1 3 short femur 0.65482476776998 1 0.81777500542417 0.102272727272727 1.3 1 3 increased sarcoma incidence 0.64785071196675 1 0.815920640332505 0.102040816326531 1.3 1 3 abnormal neuron morphology 0.673253070403605 1 0.807679017702884 0.101010101010101 1.3 1 3 abnormal social investigation 0.677132178372526 1 0.799602227525855 0.1 1.3 1 3 decreased respiratory quotient 0.665763259907598 1 0.799602227525855 0.1 1.3 1 3 increased lung adenocarcinoma incidence 0.683068792219255 1 0.783923752476329 0.0980392156862745 1.3 1 3 decreased birth weight 0.742014128479732 1 0.757517899761337 0.0947368421052632 1.3 1 3 increased thermal nociceptive threshold 0.806221924798241 1 0.702947013209543 0.0879120879120879 1.3 1 3 cochlear ganglion degeneration 0.786940805165963 1 0.689312265108496 0.0862068965517241 1.3 1 3 decreased mast cell histamine storage 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 abnormal pulmonary trunk morphology 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 decreased sensitivity to skin irradiation 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 improved righting response 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 abnormal mismatch repair 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 decreased leukotriene level 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 prolonged ST segment 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 decreased platelet alpha-granule number 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 failure of atrioventricular cushion closure 0.000178339921825633 0.00362139229013276 2.43117224638414 1 10.1 10 1 thymus cortex atrophy 0.000612178268240242 0.00976149642466412 2.43117224638414 1 10.1 10 1 abnormal ear pigmentation 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 altered response to CNS ischemic injury 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 tau protein deposits 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 abnormal kidney epithelium morphology 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 abnormal tumor incidence 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 decreased tidal volume 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 absent popliteal lymph nodes 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 heart hemorrhage 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 abnormal conotruncal ridge morphology 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 impaired embryo implantation 0.000157412821884348 0.00334670422595996 2.02597687198678 0.833333333333333 10.1 10 1 ectopic digits 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 jumpy 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal parental behavior 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 enlarged pancreas 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal leukocyte tethering or rolling 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 impaired granulocyte bactericidal activity 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal olfactory bulb layer morphology 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 myocardium hypoplasia 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal spinal cord ventral horn morphology 0.000453697144141093 0.00759980906431629 1.98914092885975 0.818181818181818 10.1 10 1 decreased mast cell number 2.37257905885447e-05 0.000737723801112562 1.97532745018711 0.8125 10.1 10 1 abnormal primordial germ cell migration 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 peritoneal inflammation 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 abnormal gas homeostasis 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 abnormal hippocampus neuron morphology 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 decreased macrophage apoptosis 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 heart hyperplasia 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 decreased level of surface class I molecules 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 increased neuronal precursor cell number 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 abnormal gallbladder physiology 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 liver hyperplasia 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 abnormal leukopoiesis 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 retropulsion 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 abnormal T cell proliferation 3.69079888460592e-08 2.82488068475607e-06 1.88219786816837 0.774193548387097 10.1 10 1 embryonic lethality before implantation, incomplete penetrance 4.1461739133282e-06 0.000170472853047998 1.87863309947865 0.772727272727273 10.1 10 1 enhanced behavioral response to cocaine 7.37311716446789e-05 0.00183406289466139 1.85913171782317 0.764705882352941 10.1 10 1 abnormal thymus involution 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 increased papilloma incidence 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 abnormal vascular endothelial cell development 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 abnormal fatty acid level 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 decreased mammary gland epithelial cell proliferation 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 disorganized yolk sac vascular plexus 0.000195430343586155 0.00381280768369066 1.82337918478811 0.75 10.1 10 1 abnormal epicardium morphology 0.000195430343586155 0.00381280768369066 1.82337918478811 0.75 10.1 10 1 small pancreas 0.000195430343586155 0.00381280768369066 1.82337918478811 0.75 10.1 10 1 absent mammary gland 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal erythrocyte cell number 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal urination 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 decreased aerobic running capacity 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal cellular cholesterol metabolism 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 increased cardiac output 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 absent interparietal bone 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal NK cell morphology 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal choroid pigmentation 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal somite size 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal olfactory bulb mitral cell layer morphology 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal cerebellum deep nucleus morphology 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 increased caudal vertebrae number 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal heart echocardiography feature 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 decreased vascular endothelial cell proliferation 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal lymph node B cell domain morphology 0.000508809408151126 0.00835421387970908 1.78285964734837 0.733333333333333 10.1 10 1 liver vascular congestion 0.000508809408151126 0.00835421387970908 1.78285964734837 0.733333333333333 10.1 10 1 abnormal stomach epithelium morphology 0.00350498479087446 0.035596099204667 1.76812527009756 0.727272727272727 10.1 10 1 abnormal crista ampullaris neuroepithelium morphology 0.00350498479087446 0.035596099204667 1.76812527009756 0.727272727272727 10.1 10 1 decreased core body temperature 0.00350498479087446 0.035596099204667 1.76812527009756 0.727272727272727 10.1 10 1 abnormal megakaryocyte differentiation 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 abnormal neutrophil morphology 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 decreased lactate dehydrogenase level 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 abnormal macrophage chemotaxis 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 abnormal cytotoxic T cell physiology 1.77444005934779e-08 1.47130654920921e-06 1.7365516045601 0.714285714285714 10.1 10 1 shortened head 4.51043290750308e-06 0.000176688218226991 1.7365516045601 0.714285714285714 10.1 10 1 lymphoid hyperplasia 4.51043290750308e-06 0.000176688218226991 1.7365516045601 0.714285714285714 10.1 10 1 increased hemangioma incidence 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 abnormal iris pigmentation 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 pulmonary alveolar hemorrhage 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 testis degeneration 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 cochlear degeneration 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 abnormal circulating free fatty acids level 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased mortality induced by ionizing radiation 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 absent deltoid tuberosity 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 abnormal body temperature 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 increased tumor latency 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased DN2 thymocyte number 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased DN4 thymocyte number 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 arteritis 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased brain cholesterol level 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 altered tumor pathology 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 dilated pulmonary alveolar ducts 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 parturition failure 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 ductus venosus stenosis 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 abnormal melanosome morphology 0.000487508356245695 0.0081115520813456 1.71612158568292 0.705882352941177 10.1 10 1 abnormal immune cell physiology 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 acrania 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 lymphedema 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 osteosclerosis 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 absent inguinal lymph nodes 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 absent axillary lymph nodes 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 abnormal inferior vena cava valve morphology 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 abnormal xiphoid process morphology 2.72424763698514e-05 0.000821401939030369 1.68311924749671 0.692307692307692 10.1 10 1 absent hypoglossal nerve 0.00323238487766256 0.0335677275831593 1.68311924749671 0.692307692307692 10.1 10 1 abnormal vascular branching morphogenesis 0.000171084587154273 0.00350265769996916 1.65761744071646 0.681818181818182 10.1 10 1 abnormal ovulation 2.52074663176211e-05 0.000778926366025868 1.6497240243321 0.678571428571429 10.1 10 1 decreased susceptibility to bacterial infection induced morbidity/mortality 9.7514023396688e-06 0.00034164244112572 1.64692313464732 0.67741935483871 10.1 10 1 increased brain weight 5.94013275309009e-05 0.0015312000231411 1.62078149758943 0.666666666666667 10.1 10 1 hemolytic anemia 0.000154755895137843 0.00330433724596896 1.62078149758943 0.666666666666667 10.1 10 1 abnormal cardiac muscle contractility 0.000154755895137843 0.00330433724596896 1.62078149758943 0.666666666666667 10.1 10 1 abnormal cellular extravasation 0.000154755895137843 0.00330433724596896 1.62078149758943 0.666666666666667 10.1 10 1 abnormal tumor vascularization 0.000405911718846759 0.00698758062720633 1.62078149758943 0.666666666666667 10.1 10 1 absent allantois 0.00107404761364574 0.0151800763576351 1.62078149758943 0.666666666666667 10.1 10 1 primary atelectasis 0.00107404761364574 0.0151800763576351 1.62078149758943 0.666666666666667 10.1 10 1 abnormal mating frequency 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 myocarditis 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal embryonic growth/weight/body size 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal respiratory function 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 pale placenta 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal palatine bone morphology 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal head movements 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal kindling response 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 genetic imprinting 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 enlarged otoliths 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal artery development 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 premature bone ossification 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal thymus physiology 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 small scapula 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal inguinal fat pad morphology 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased susceptibility to atherosclerosis 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 absent cervical lymph nodes 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 axonal spheroids 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 cerebellum atrophy 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased platelet dense granule number 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 impaired macrophage chemotaxis 1.34823368163108e-06 6.32779487369304e-05 1.62078149758943 0.666666666666667 10.1 10 1 absent chorion 0.00287572401185003 0.0310341148784249 1.62078149758943 0.666666666666667 10.1 10 1 abnormal secondary palate development 0.00287572401185003 0.0310341148784249 1.62078149758943 0.666666666666667 10.1 10 1 lordosis 5.30834931549706e-05 0.00141984074433322 1.5928369890103 0.655172413793103 10.1 10 1 abnormal embryonic erythropoiesis 5.30834931549706e-05 0.00141984074433322 1.5928369890103 0.655172413793103 10.1 10 1 ventricular hypoplasia 0.000137690372687708 0.00304448712942822 1.58961262263578 0.653846153846154 10.1 10 1 spleen hyperplasia 9.0814358511742e-11 1.30338938963727e-08 1.58836586763764 0.653333333333333 10.1 10 1 dilated heart 0.000359148204221106 0.00626934145964914 1.58554711720705 0.652173913043478 10.1 10 1 abnormal vasculogenesis 1.090265619312e-06 5.37036777829424e-05 1.58308890462223 0.651162790697674 10.1 10 1 abnormal pericardium morphology 0.000943440869192479 0.0138047597771547 1.58026196014969 0.65 10.1 10 1 decreased myocardial infarction size 0.000943440869192479 0.0138047597771547 1.58026196014969 0.65 10.1 10 1 abnormal spleen red pulp morphology 1.82295676195487e-05 0.000600609926538112 1.57311145354268 0.647058823529412 10.1 10 1 abnormal dorsal-ventral axis patterning 0.00250125750576607 0.027530433830058 1.57311145354268 0.647058823529412 10.1 10 1 pancytopenia 0.00250125750576607 0.027530433830058 1.57311145354268 0.647058823529412 10.1 10 1 abnormal kidney blood vessel morphology 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 absent visceral yolk sac blood islands 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 abnormal antigen presentation 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 decreased coping response 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 vascular smooth muscle hypoplasia 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 increased B-1 B cell number 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 abnormal viscerocranium morphology 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 spina bifida occulta 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 increased lung compliance 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 decreased response to antigen 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 decreased B-1 B cell number 6.27259268888618e-06 0.000231156656497843 1.55844374768214 0.641025641025641 10.1 10 1 abnormal interventricular septum morphology 3.36864942497366e-07 1.90443532832318e-05 1.55595023768585 0.64 10.1 10 1 abnormal lysosome physiology 0.000816859199308617 0.0123898613309767 1.54710961133536 0.636363636363636 10.1 10 1 decreased circulating estradiol level 0.000816859199308617 0.0123898613309767 1.54710961133536 0.636363636363636 10.1 10 1 abnormal thrombopoiesis 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 decreased atrioventricular cushion size 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal eye distance/ position 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 patent ductus arteriosus 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal radial glial cell morphology 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal dorsal-ventral polarity of the somites 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal fat pad morphology 0.000105178979504014 0.0024451655281891 1.53974242270996 0.633333333333333 10.1 10 1 decreased B cell proliferation 3.17779875591745e-10 4.05373046427931e-08 1.53871661163553 0.632911392405063 10.1 10 1 increased T cell derived lymphoma incidence 7.47322318493583e-07 3.87284222344331e-05 1.53808856403895 0.63265306122449 10.1 10 1 kyphoscoliosis 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 decreased tumor incidence 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 increased left ventricle weight 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 decreased liver regeneration 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 abnormal lymphocyte physiology 1.88840692007898e-06 8.69891150684528e-05 1.53269554663348 0.630434782608696 10.1 10 1 abnormal atrioventricular cushion morphology 0.000270781749454283 0.00498940445753726 1.53073808105668 0.62962962962963 10.1 10 1 abnormal liver development 3.55561398492612e-05 0.00102249592919118 1.52816541201289 0.628571428571429 10.1 10 1 impaired muscle relaxation 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 abnormal pulmonary elastic fiber morphology 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 sepsis 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 decreased circulating triiodothyronine level 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 decreased creatinine clearance 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 failure of vascular branching 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 dermal cysts 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 dry eyes 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 head spot 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 hypospadia 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal umbilical artery morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal perineum morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal platelet shape 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 pulmonary interstitial fibrosis 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 binucleate 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal skin development 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal extraembryonic tissue physiology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 non-pigmented tail tip 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal ilium morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal mast cell differentiation 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 choroidal neovascularization 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased pulmonary ventilation 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal epidermal lamellar body morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal sphingomyelin level 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal circulating serum amyloid protein level 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 heart right ventricle hypoplasia 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal hepatic vein morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 myocardial trabeculae hypoplasia 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 delayed suture closure 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 decreased lung compliance 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased aorta wall thickness 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal macrophage activation involved in immune response 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 absent Reichert's membrane 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased cornea thickness 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 absent hypoglossal canal 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased mammary gland apoptosis 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased mortality induced by gamma-irradiation 0.000232005016085441 0.0043720642235798 1.50900346327292 0.620689655172414 10.1 10 1 abnormal response to infection 1.31376950560657e-09 1.48545529327106e-07 1.50794227940282 0.620253164556962 10.1 10 1 abnormal erythropoiesis 3.18783427703415e-12 6.34379021129795e-10 1.50501139061875 0.619047619047619 10.1 10 1 abnormal eye pigmentation 0.00181692573850427 0.022156544258372 1.50501139061875 0.619047619047619 10.1 10 1 left pulmonary isomerism 0.00181692573850427 0.022156544258372 1.50501139061875 0.619047619047619 10.1 10 1 abnormal erythrocyte physiology 0.00181692573850427 0.022156544258372 1.50501139061875 0.619047619047619 10.1 10 1 decreased regulatory T cell number 7.77468525237611e-05 0.00192433130002842 1.50160638747256 0.617647058823529 10.1 10 1 abnormal leukocyte adhesion 2.62627708684951e-05 0.000801578436016951 1.49610599777486 0.615384615384615 10.1 10 1 abnormal placenta vasculature 1.21939973665441e-06 5.94756244103498e-05 1.49610599777486 0.615384615384615 10.1 10 1 absent teeth 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 absent common myeloid progenitor cells 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 abnormal mast cell morphology 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 lymphoid hypoplasia 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 abnormal otolith morphology 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 abnormal afterhyperpolarization 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 extramedullary hematopoiesis 5.89556260732159e-12 1.08579300159677e-09 1.49081316995254 0.613207547169811 10.1 10 1 inner cell mass degeneration 0.000197499608156733 0.00382319280381225 1.49007331229996 0.612903225806452 10.1 10 1 abnormal CD8-positive, alpha beta T cell morphology 0.000197499608156733 0.00382319280381225 1.49007331229996 0.612903225806452 10.1 10 1 pallor 1.35714732287041e-18 6.13800721025482e-16 1.48648817350345 0.611428571428571 10.1 10 1 abnormal lysosome morphology 6.62632698358803e-05 0.00169056290991541 1.48571637279031 0.611111111111111 10.1 10 1 abnormal mitral valve morphology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 abnormal phrenic nerve morphology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 abnormal thymus medulla morphology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 abnormal hypoglossal nerve topology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 increased B cell proliferation 3.59649908751701e-07 2.0104025798199e-05 1.48342713338693 0.610169491525424 10.1 10 1 abnormal allantois morphology 7.62014864026138e-06 0.00027273553586547 1.47984397605991 0.608695652173913 10.1 10 1 increased granulocyte number 1.48573837388759e-08 1.31991935894477e-06 1.4784155552336 0.608108108108108 10.1 10 1 increased bone marrow cell number 5.622122493491e-05 0.0014877691172935 1.47149899123251 0.605263157894737 10.1 10 1 decreased hair follicle number 5.622122493491e-05 0.0014877691172935 1.47149899123251 0.605263157894737 10.1 10 1 abnormal osteoclast morphology 6.48190072277718e-06 0.000236256313122533 1.46883323219042 0.604166666666667 10.1 10 1 increased B cell derived lymphoma incidence 5.4965282603224e-06 0.000207160818902303 1.45870334783048 0.6 10.1 10 1 decreased acute inflammation 0.00127928740993837 0.0173095447453598 1.45870334783048 0.6 10.1 10 1 abnormal circulating enzyme level 0.0039423908448023 0.0383823766201398 1.45870334783048 0.6 10.1 10 1 abnormal induced retinal neovascularization 0.0039423908448023 0.0383823766201398 1.45870334783048 0.6 10.1 10 1 abnormal neuron proliferation 0.0039423908448023 0.0383823766201398 1.45870334783048 0.6 10.1 10 1 increased cranium width 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 decreased incidence of induced tumors 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal airway responsiveness 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 impaired basement membrane formation 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal submandibular gland morphology 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 increased platelet aggregation 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 decreased transitional stage T2 B cell number 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal cerebellar granule cell migration 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 acanthocytosis 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal heart and great artery attachment 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal left subclavian artery morphology 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 thin ventricle myocardium compact layer 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal adaptive thermogenesis 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 decreased macrophage cytokine production 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 thick pulmonary interalveolar septum 0.000141032921535509 0.00305060341147461 1.45870334783048 0.6 10.1 10 1 increased circulating serum albumin level 0.000141032921535509 0.00305060341147461 1.45870334783048 0.6 10.1 10 1 abnormal kidney development 6.46787177781233e-07 3.38712232574909e-05 1.45870334783048 0.6 10.1 10 1 abnormal response to new environment 0.000422244070957582 0.0072182523172675 1.45870334783048 0.6 10.1 10 1 decreased hepatocyte number 0.0124730938836344 0.0873343166507914 1.45870334783048 0.6 10.1 10 1 vagina atresia 0.0124730938836344 0.0873343166507914 1.45870334783048 0.6 10.1 10 1 abnormal dendritic cell morphology 0.0124730938836344 0.0873343166507914 1.45870334783048 0.6 10.1 10 1 abnormal leukocyte migration 4.64821550076725e-06 0.000180663063408727 1.44935268534439 0.596153846153846 10.1 10 1 increased circulating phosphate level 0.000118506710605607 0.00271691652194883 1.44556187622841 0.594594594594595 10.1 10 1 abnormal embryonic hematopoiesis 0.000353552017900586 0.00619338482061767 1.44350852129058 0.59375 10.1 10 1 decreased blood urea nitrogen level 3.36387505386138e-05 0.000978671251050314 1.43660178195427 0.590909090909091 10.1 10 1 abnormal germ layer development 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 intestinal inflammation 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 increased skin papilloma incidence 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 failure of palatal shelf elevation 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 small lung 9.628548924728e-06 0.000341128724807604 1.43010132140244 0.588235294117647 10.1 10 1 abnormal bone marrow cavity morphology 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 hyperlipidemia 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 increased regulatory T cell number 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 abnormal ectoplacental cone morphology 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 failure to gastrulate 2.81965323413276e-05 0.000845046677097017 1.42699240548634 0.58695652173913 10.1 10 1 short sternum 0.000885313300268952 0.0131084335382084 1.42516993753553 0.586206896551724 10.1 10 1 abnormal CD8-positive, alpha-beta T cell physiology 0.000885313300268952 0.0131084335382084 1.42516993753553 0.586206896551724 10.1 10 1 reduced long term depression 0.000245710433914992 0.00459552409295896 1.41818381039075 0.583333333333333 10.1 10 1 small lymph nodes 0.00268952691956353 0.0291511904680361 1.41818381039075 0.583333333333333 10.1 10 1 abnormal tumor morphology 0.00268952691956353 0.0291511904680361 1.41818381039075 0.583333333333333 10.1 10 1 increased hemangiosarcoma incidence 0.00268952691956353 0.0291511904680361 1.41818381039075 0.583333333333333 10.1 10 1 interstitial pneumonia 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal gastrocnemius morphology 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 small intestinal inflammation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 absent ovary 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 increased osteosarcoma incidence 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal defecation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal B cell proliferation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal somatic nervous system physiology 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 decreased keratinocyte proliferation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 impaired behavioral response to cocaine 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 decreased red blood cell distribution width 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 persistent right dorsal aorta 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal placenta morphology 6.80478543352589e-08 4.6375078810673e-06 1.41561928270469 0.582278481012658 10.1 10 1 increased T cell proliferation 5.02914542604649e-10 5.95714249870983e-08 1.40871662874595 0.579439252336449 10.1 10 1 thrombocytopenia 4.69252824833084e-13 1.11168228740219e-10 1.40840323238805 0.579310344827586 10.1 10 1 stereotypic behavior 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 maternal imprinting 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 absent amnion 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 Leydig cell hypoplasia 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 trabecula carnea hypoplasia 5.76130232183656e-05 0.00150532473281745 1.40467729791084 0.577777777777778 10.1 10 1 abnormal myocardial trabeculae morphology 5.76130232183656e-05 0.00150532473281745 1.40467729791084 0.577777777777778 10.1 10 1 liver hypoplasia 1.64199126846744e-05 0.000544593770708367 1.40259937291393 0.576923076923077 10.1 10 1 abnormal leukocyte cell number 0.00221276189420375 0.0253651853079807 1.40259937291393 0.576923076923077 10.1 10 1 increased leukemia incidence 0.00221276189420375 0.0253651853079807 1.40259937291393 0.576923076923077 10.1 10 1 increased spleen weight 2.9680631494336e-10 3.88581951800846e-08 1.3984619116369 0.575221238938053 10.1 10 1 decreased tumor growth/size 1.36707405158244e-05 0.000465835164837168 1.39567295625756 0.574074074074074 10.1 10 1 decreased erythrocyte cell number 1.6391827593306e-13 4.29207064614196e-11 1.39366561894632 0.573248407643312 10.1 10 1 abnormal spleen white pulp morphology 0.000140234187725576 0.00305060341147461 1.38924128364808 0.571428571428571 10.1 10 1 abnormal spleen germinal center morphology 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 abnormal brainstem morphology 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 prolonged QRS complex duration 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 subcutaneous edema 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 abnormal embryonic/fetal subventricular zone morphology 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 increased acute inflammation 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 vascular ring 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 absent segment of posterior cerebral artery 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 abnormal blood flow velocity 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 increased aggression towards males 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 absent otoliths 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 abnormal kidney medulla morphology 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 intestinal obstruction 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 amyloid beta deposits 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 failure of zygotic cell division 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 lysosomal protein accumulation 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 decreased tongue size 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 abnormal dermal layer morphology 0.000500556202880221 0.0082733126555784 1.38924128364808 0.571428571428571 10.1 10 1 increased carcinoma incidence 0.000500556202880221 0.0082733126555784 1.38924128364808 0.571428571428571 10.1 10 1 abnormal inflammatory response 7.88310415343801e-07 4.0018819554443e-05 1.38441752919097 0.569444444444444 10.1 10 1 abnormal myelopoiesis 0.000116000174021679 0.00267176326739746 1.38134786726372 0.568181818181818 10.1 10 1 lung inflammation 2.08261064169072e-11 3.3422541749714e-09 1.37647252184984 0.566176470588235 10.1 10 1 enlarged spleen 1.8490886436776e-22 1.31417371461372e-19 1.37597595889102 0.565972222222222 10.1 10 1 abnormal immune system morphology 9.58544613585145e-05 0.00227083783456481 1.37414083491278 0.565217391304348 10.1 10 1 abnormal postnatal growth 0.00551386217405388 0.0497848717167297 1.37414083491278 0.565217391304348 10.1 10 1 increased susceptibility to fungal infection 0.00551386217405388 0.0497848717167297 1.37414083491278 0.565217391304348 10.1 10 1 abnormal chondrocyte physiology 0.00551386217405388 0.0497848717167297 1.37414083491278 0.565217391304348 10.1 10 1 abnormal response to injury 0.000339853989664203 0.00599565105879224 1.37143049796028 0.564102564102564 10.1 10 1 decreased circulating total protein level 2.25992184798206e-05 0.000707113911554136 1.37029708432561 0.563636363636364 10.1 10 1 scoliosis 0.00122184160386213 0.0169555598394097 1.36753438859108 0.5625 10.1 10 1 abnormal spongiotrophoblast layer morphology 0.00122184160386213 0.0169555598394097 1.36753438859108 0.5625 10.1 10 1 abnormal epididymis epithelium morphology 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 increased thymus weight 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 abnormal Langerhans cell physiology 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 kidney degeneration 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 decreased birth body size 1.59303699723191e-09 1.76119090249527e-07 1.36486862954899 0.56140350877193 10.1 10 1 abnormal cell differentiation 0.000279653017924344 0.00513385152831591 1.36382833333744 0.560975609756098 10.1 10 1 abnormal inner ear vestibule morphology 0.00448437720454103 0.0426573166206341 1.36145645797512 0.56 10.1 10 1 abnormal primitive streak morphology 0.00448437720454103 0.0426573166206341 1.36145645797512 0.56 10.1 10 1 abnormal preimplantation embryo development 0.00448437720454103 0.0426573166206341 1.36145645797512 0.56 10.1 10 1 abnormal oocyte morphology 0.00100067017962831 0.0145140937132677 1.35859625533231 0.558823529411765 10.1 10 1 decreased cytotoxic T cell cytolysis 0.00100067017962831 0.0145140937132677 1.35859625533231 0.558823529411765 10.1 10 1 abnormal cytokine secretion 4.00103579022184e-12 7.65582809859755e-10 1.35766761811062 0.558441558441558 10.1 10 1 abnormal spleen morphology 2.01630185162153e-13 5.01555085590856e-11 1.35530866608771 0.557471264367816 10.1 10 1 abnormal vitelline vasculature morphology 2.57137007341883e-09 2.72182257771461e-07 1.35300020668335 0.556521739130435 10.1 10 1 increased susceptibility to bacterial infection induced morbidity/mortality 2.52168509107407e-06 0.000108149856276668 1.35065124799119 0.555555555555556 10.1 10 1 lowered ear position 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 abnormal Peyer's patch follicle morphology 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 increased circulating glycerol level 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 absent ureter 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 absent inner cell mass 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 jerky movement 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 abnormal pregnancy 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 small thoracic cage 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 increased gastrointestinal tumor incidence 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 decreased tumor latency 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 impaired leukocyte tethering or rolling 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 abnormal sympathetic neuron morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal lens vesicle development 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 long gestation period 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal thymus lobule morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal posterior semicircular canal morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased circulating bicarbonate level 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal lens capsule morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased susceptibility to induced choroidal neovascularization 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased fear-related response 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 impaired febrile response 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal bony labyrinth 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 absent adrenal gland 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased tidal volume 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 enhanced conditioned place preference behavior 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased transitional stage T1 B cell number 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal hippocampus granule cell morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal cerebellar layer morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 shortened ST segment 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 iris coloboma 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal pulmonary alveolar system morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal pulmonary alveolar parenchyma morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal oxidative phosphorylation 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased core body temperature 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased bone trabecular spacing 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased myeloid cell number 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal infrahyoid muscle connection 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal coronary sinus connection 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased cardiac muscle glycogen level 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased fatty acid oxidation 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal apoptosis 4.43502118195218e-05 0.0012123203505611 1.35065124799119 0.555555555555556 10.1 10 1 abnormal cell adhesion 4.43502118195218e-05 0.0012123203505611 1.35065124799119 0.555555555555556 10.1 10 1 abnormal bone trabecula morphology 0.00364627593370696 0.0362804455403842 1.35065124799119 0.555555555555556 10.1 10 1 decreased lymphocyte cell number 4.33174955787955e-10 5.25620830498799e-08 1.3485408554162 0.5546875 10.1 10 1 abnormal T cell activation 2.08347502625982e-06 9.25472165682376e-05 1.34700083921283 0.554054054054054 10.1 10 1 short mandible 3.65257882329504e-05 0.00104434365780993 1.34582749353408 0.553571428571429 10.1 10 1 incomplete somite formation 0.000670243992198006 0.0104528647686053 1.34354255721229 0.552631578947368 10.1 10 1 decreased neuron apoptosis 0.000670243992198006 0.0104528647686053 1.34354255721229 0.552631578947368 10.1 10 1 thrombocytosis 3.00691062949452e-05 0.000890439308436621 1.34133641179815 0.551724137931034 10.1 10 1 decreased trophoblast giant cell number 0.00296465555354895 0.0317869857304009 1.34133641179815 0.551724137931034 10.1 10 1 blood in lymph vessels 0.00296465555354895 0.0317869857304009 1.34133641179815 0.551724137931034 10.1 10 1 organ of Corti degeneration 0.000127470150108052 0.00288256362176164 1.33962552351779 0.551020408163265 10.1 10 1 abnormal vascular regression 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 abnormal hearing physiology 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 abnormal Peyer's patch T cell area morphology 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 abnormal physiological neovascularization 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 increased skin tumor incidence 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 absent ductus venosus valve 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 anemia 3.63449422268059e-15 1.20544058385573e-12 1.33656862834389 0.549763033175355 10.1 10 1 abnormal CD4-positive, alpha-beta T cell physiology 4.86901219025411e-06 0.000187777795709412 1.33543264238002 0.549295774647887 10.1 10 1 failure of chorioallantoic fusion 0.000104635016494782 0.00244393993925607 1.33476123330894 0.549019607843137 10.1 10 1 abnormal embryo size 9.50264065451e-09 9.26973279533084e-07 1.33391751571519 0.548672566371681 10.1 10 1 osteopetrosis 0.00241060988218017 0.0270218488391995 1.33322348995259 0.548387096774194 10.1 10 1 abnormal postnatal growth/weight/body size 0.00241060988218017 0.0270218488391995 1.33322348995259 0.548387096774194 10.1 10 1 abnormal capillary morphology 0.00241060988218017 0.0270218488391995 1.33322348995259 0.548387096774194 10.1 10 1 astrocytosis 4.0115808258377e-06 0.000166313455071188 1.3321491761009 0.547945205479452 10.1 10 1 spina bifida 0.000448423180796536 0.00756239093038227 1.33135623016274 0.547619047619048 10.1 10 1 lethality throughout fetal growth and development, complete penetrance 1.37277784462105e-13 3.79420543166097e-11 1.33074691381027 0.547368421052632 10.1 10 1 increased inflammatory response 1.59704695593181e-07 9.80902297007501e-06 1.33074691381027 0.547368421052632 10.1 10 1 decreased neutrophil cell number 6.48983103075742e-09 6.58916517918738e-07 1.32987199802209 0.547008547008547 10.1 10 1 abnormal ovarian folliculogenesis 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 decreased brown adipose tissue amount 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 increased cardiomyocyte apoptosis 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 abnormal locomotor coordination 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 abnormal T cell subpopulation ratio 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 abnormal channel response 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 abnormal blood-brain barrier function 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 abnormal mesenteric lymph node morphology 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 pulmonary vascular congestion 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 absent semicircular canals 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal sphenoid bone morphology 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal hemoglobin 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 impaired myelopoiesis 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal proximal-distal axis patterning 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal palate development 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 palatal shelf hypoplasia 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 common atrioventricular valve 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal dendritic cell chemotaxis 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal pulmonary alveolar sac morphology 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 thin hypoglossal nerve 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 increased insulin sensitivity 1.82372666001561e-10 2.52028892599379e-08 1.32609395257317 0.545454545454545 10.1 10 1 abnormal T cell differentiation 8.96897372211641e-08 5.91020426061713e-06 1.32390567872404 0.544554455445545 10.1 10 1 abnormal nervous system morphology 2.24009346116639e-06 9.86235837991397e-05 1.32329628600656 0.544303797468354 10.1 10 1 pericardial edema 1.13162682910045e-05 0.000388265067225845 1.32284372229725 0.544117647058823 10.1 10 1 decreased susceptibility to induced arthritis 5.77923666267606e-05 0.00150532473281745 1.32221648487559 0.543859649122807 10.1 10 1 abnormal myelin sheath morphology 0.000299852744867849 0.00544440659021004 1.32128926433921 0.543478260869565 10.1 10 1 embryonic lethality between implantation and placentation, complete penetrance 0.000299852744867849 0.00544440659021004 1.32128926433921 0.543478260869565 10.1 10 1 abnormal artery morphology 0.00159455552701665 0.0201409743941904 1.31977921946568 0.542857142857143 10.1 10 1 decreased circulating thyroxine level 0.00159455552701665 0.0201409743941904 1.31977921946568 0.542857142857143 10.1 10 1 decreased body height 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 decreased metastatic potential 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 abnormal primitive streak formation 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 prolonged QT interval 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 decreased T cell proliferation 1.93739231412674e-10 2.60500723318393e-08 1.31414716020764 0.540540540540541 10.1 10 1 short stride length 0.000200468477740958 0.00386562277814443 1.31283301304744 0.54 10.1 10 1 embryonic lethality, complete penetrance 1.42049971210159e-20 7.63336242259402e-18 1.31085149334819 0.539184952978056 10.1 10 1 decreased monocyte cell number 2.61373850983133e-05 0.000801578436016951 1.309092748053 0.538461538461538 10.1 10 1 abnormal brain wave pattern 0.000163913810719104 0.00341201342396461 1.309092748053 0.538461538461538 10.1 10 1 heart inflammation 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 abnormal erythrocyte osmotic lysis 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 decreased bone resorption 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 increased thymocyte apoptosis 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 absent trabeculae carneae 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal renal/urinary system morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 uterus hypoplasia 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal pulmonary alveolus epithelial cell morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal lung interstitium morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal coping response 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal telomere length 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 axonal dystrophy 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 muscle fatigue 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal exocrine pancreas morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 hyperalgesia 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 increased prostaglandin level 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal heart development 7.39536801368022e-11 1.14974862087685e-08 1.3079091198902 0.537974683544304 10.1 10 1 abnormal lung morphology 1.57297879807257e-08 1.3492361242088e-06 1.30752120813937 0.53781512605042 10.1 10 1 abnormal definitive hematopoiesis 5.71521435661339e-07 3.024807598314e-05 1.3070818528947 0.537634408602151 10.1 10 1 increased cell proliferation 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 diluted coat color 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 abnormal mandible morphology 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 decreased platelet aggregation 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 liver fibrosis 0.000859322498775687 0.0128741642256753 1.3045314492793 0.536585365853659 10.1 10 1 increased bone trabecula number 0.000859322498775687 0.0128741642256753 1.3045314492793 0.536585365853659 10.1 10 1 abnormal stria vascularis morphology 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 reddish skin 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 abnormal somite shape 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 premature aging 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 hypoxia 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 edema 1.91137667249931e-11 3.16969964856135e-09 1.30039445736826 0.534883720930233 10.1 10 1 impaired macrophage phagocytosis 0.000699659699328944 0.0108099596402531 1.30039445736826 0.534883720930233 10.1 10 1 kidney failure 0.000699659699328944 0.0108099596402531 1.30039445736826 0.534883720930233 10.1 10 1 embryonic lethality between implantation and somite formation, complete penetrance 1.20610610762803e-15 4.28598420389246e-13 1.29993291541356 0.53469387755102 10.1 10 1 cochlear ganglion degeneration 8.96227766373638e-05 0.00214362170082156 1.29941964892945 0.53448275862069 10.1 10 1 abnormal embryonic neuroepithelium morphology 8.96227766373638e-05 0.00214362170082156 1.29941964892945 0.53448275862069 10.1 10 1 abnormal cell migration 0.000569813312071153 0.0092127143110254 1.29662519807154 0.533333333333333 10.1 10 1 abnormal eating behavior 7.32938538229662e-05 0.00183234634557415 1.29662519807154 0.533333333333333 10.1 10 1 abnormal synaptic transmission 0.00464898719261239 0.0432312360434517 1.29662519807154 0.533333333333333 10.1 10 1 liver hemorrhage 0.00464898719261239 0.0432312360434517 1.29662519807154 0.533333333333333 10.1 10 1 abnormal cellular respiration 0.00464898719261239 0.0432312360434517 1.29662519807154 0.533333333333333 10.1 10 1 absent incisors 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal prostate gland morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 hyperpigmentation 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 audiogenic seizures 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 increased airway responsiveness 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal bronchus morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 delayed intramembranous bone ossification 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal pericyte morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 decreased aggression towards males 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal trophectoderm morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal olfactory nerve morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal energy homeostasis 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal aorta wall morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 bicuspid aortic valve 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal coronary vessel morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal dendritic cell physiology 1.4502655492776e-07 9.13300140209629e-06 1.29511044900837 0.532710280373832 10.1 10 1 abnormal myocardium layer morphology 6.50595274327377e-06 0.000236256313122533 1.29252195377385 0.531645569620253 10.1 10 1 increased dopamine level 0.00375788059760731 0.0368746666136023 1.29156025589157 0.53125 10.1 10 1 increased fibroblast apoptosis 0.00375788059760731 0.0368746666136023 1.29156025589157 0.53125 10.1 10 1 increased sarcoma incidence 0.000378237653258305 0.00655655862355424 1.2900097633875 0.530612244897959 10.1 10 1 abnormal vascular development 4.01053045036663e-05 0.00110846605503189 1.28925800944614 0.53030303030303 10.1 10 1 pale yolk sac 4.37234805411552e-06 0.000176040463578132 1.28881420290244 0.530120481927711 10.1 10 1 increased B cell number 5.43494505908509e-08 3.77286548559504e-06 1.2883134980839 0.52991452991453 10.1 10 1 impaired hematopoiesis 0.000308281121642904 0.00553449280085155 1.28709118926219 0.529411764705882 10.1 10 1 increased lung adenocarcinoma incidence 0.000308281121642904 0.00553449280085155 1.28709118926219 0.529411764705882 10.1 10 1 abnormal thrombosis 0.000308281121642904 0.00553449280085155 1.28709118926219 0.529411764705882 10.1 10 1 short maxilla 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 enlarged liver sinusoidal spaces 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 thin skin 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 increased susceptibility to viral infection induced morbidity/mortality 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 abnormal adipose tissue morphology 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 abnormal interatrial septum morphology 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 absence seizures 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 aminoaciduria 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 increased brain size 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 abnormal circulating chemokine level 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 increased trabecular bone mass 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 embryonic lethality between somite formation and embryo turning, complete penetrance 2.68408089511687e-05 0.000814225759341856 1.28504818737447 0.528571428571429 10.1 10 1 abnormal muscle physiology 2.40909824946826e-06 0.00010430688312223 1.28387747842758 0.528089887640449 10.1 10 1 abnormal trophoblast giant cell morphology 0.00246122612382065 0.0273316963526958 1.28311868559163 0.527777777777778 10.1 10 1 abnormal platelet physiology 0.000204941159265198 0.00390236136130139 1.28189082082073 0.527272727272727 10.1 10 1 increased macrophage cell number 0.000167156320753684 0.00345063359232191 1.27956434020218 0.526315789473684 10.1 10 1 impaired branching involved in ureteric bud morphogenesis 0.00199400280745801 0.0237893620314235 1.27956434020218 0.526315789473684 10.1 10 1 flaky skin 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 shiny skin 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 abnormal stationary movement 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 unresponsive to tactile stimuli 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 increased malignant tumor incidence 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 abnormal sternebra morphology 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 increased liver cholesterol level 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 decreased circulating magnesium level 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 decreased liver glycogen level 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 abnormal immune system physiology 4.53683686390813e-08 3.27112513013666e-06 1.27440480657233 0.524193548387097 10.1 10 1 abnormal pancreas morphology 0.00131131174855275 0.0174391300307673 1.27347117667741 0.523809523809524 10.1 10 1 abnormal scapula morphology 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 trunk curl 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 liver degeneration 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 embryonic lethality at implantation, complete penetrance 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 skin lesions 9.08182060235445e-05 0.0021618209328571 1.27347117667741 0.523809523809524 10.1 10 1 increased T cell number 4.4231272255812e-06 0.000176040463578132 1.27084003788262 0.522727272727273 10.1 10 1 abnormal inner ear morphology 0.000864315749020213 0.0128741642256753 1.26843769376564 0.521739130434783 10.1 10 1 abnormal cell death 0.000864315749020213 0.0128741642256753 1.26843769376564 0.521739130434783 10.1 10 1 fragile skeleton 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 bidirectional circling 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal crista ampullaris morphology 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal corneal stroma morphology 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal palatal shelf fusion at midline 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal hematopoietic stem cell physiology 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 increased susceptibility to pharmacologically induced seizures 1.98871569293384e-06 8.92768383434098e-05 1.26623554499174 0.520833333333333 10.1 10 1 decreased percent body fat/body weight 3.29828409588548e-05 0.00096523313982531 1.26554171729585 0.520547945205479 10.1 10 1 increased circulating chloride level 0.000570820926735435 0.0092127143110254 1.26420956811975 0.52 10.1 10 1 abnormal nest building behavior 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 abnormal egg cylinder morphology 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 increased pre-B cell number 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 abnormal cochlear outer hair cell morphology 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 neurodegeneration 0.000377644959239114 0.00655655862355424 1.26060783145844 0.518518518518518 10.1 10 1 abnormal type II pneumocyte morphology 0.0108912464404872 0.0778505043698621 1.26060783145844 0.518518518518518 10.1 10 1 abnormal palate morphology 0.0108912464404872 0.0778505043698621 1.26060783145844 0.518518518518518 10.1 10 1 thick interventricular septum 0.0108912464404872 0.0778505043698621 1.26060783145844 0.518518518518518 10.1 10 1 embryonic lethality during organogenesis, complete penetrance 9.3781249688477e-30 1.37780502129673e-26 1.25899991330607 0.517857142857143 10.1 10 1 dermatitis 0.000250227975164029 0.0046450902106009 1.25750288606076 0.517241379310345 10.1 10 1 increased susceptibility to induced arthritis 0.00874772088033742 0.0680389878130877 1.25750288606076 0.517241379310345 10.1 10 1 enlarged epididymis 0.00874772088033742 0.0680389878130877 1.25750288606076 0.517241379310345 10.1 10 1 liver inflammation 1.81868190878735e-07 1.09011355376109e-05 1.25610566063181 0.516666666666667 10.1 10 1 absent mesoderm 0.000203792802534198 0.00389949689464475 1.25610566063181 0.516666666666667 10.1 10 1 intracranial hemorrhage 0.000203792802534198 0.00389949689464475 1.25610566063181 0.516666666666667 10.1 10 1 abnormal B cell differentiation 5.38026958245663e-06 0.000204753948576084 1.25566039098961 0.516483516483517 10.1 10 1 hypoglycemia 4.40135539417084e-06 0.000176040463578132 1.25479857877891 0.516129032258065 10.1 10 1 pale kidney 0.00703658965707343 0.0587212135004652 1.25479857877891 0.516129032258065 10.1 10 1 enlarged pericardium 0.00566771991815435 0.0502956104192238 1.2524220663191 0.515151515151515 10.1 10 1 belly spot 0.00566771991815435 0.0502956104192238 1.2524220663191 0.515151515151515 10.1 10 1 decreased circulating serum albumin level 2.41111388121737e-06 0.00010430688312223 1.2524220663191 0.515151515151515 10.1 10 1 ovary cysts 0.00457060171762265 0.0430431607251859 1.25031715528327 0.514285714285714 10.1 10 1 abnormal midbrain development 0.00457060171762265 0.0430431607251859 1.25031715528327 0.514285714285714 10.1 10 1 decreased triglyceride level 0.00457060171762265 0.0430431607251859 1.25031715528327 0.514285714285714 10.1 10 1 abnormal forebrain development 5.98410646077101e-05 0.00153458400218226 1.24935240439185 0.513888888888889 10.1 10 1 decreased hematocrit 1.37329077344409e-08 1.2519927689048e-06 1.24888985259459 0.513698630136986 10.1 10 1 abnormal branching of the mammary ductal tree 0.00368982785512566 0.0364224078953376 1.24843980219726 0.513513513513513 10.1 10 1 decreased width of hypertrophic chondrocyte zone 0.00368982785512566 0.0364224078953376 1.24843980219726 0.513513513513513 10.1 10 1 increased trabecular bone volume 0.00368982785512566 0.0364224078953376 1.24843980219726 0.513513513513513 10.1 10 1 reduced female fertility 1.06237672196165e-12 2.40242008716327e-10 1.24702369534359 0.512931034482759 10.1 10 1 increased hepatocyte apoptosis 0.00298169103093581 0.031900887911625 1.24675499814571 0.512820512820513 10.1 10 1 abnormal bone mineralization 2.67242218164188e-07 1.5459651574033e-05 1.24572462211419 0.512396694214876 10.1 10 1 sparse hair 2.16958388626718e-05 0.000687495530839441 1.24523456522115 0.51219512195122 10.1 10 1 abnormal mammary gland development 0.00241159816775971 0.0270218488391995 1.24523456522115 0.51219512195122 10.1 10 1 arrested B cell differentiation 0.00241159816775971 0.0270218488391995 1.24523456522115 0.51219512195122 10.1 10 1 palatal shelves fail to meet at midline 0.00241159816775971 0.0270218488391995 1.24523456522115 0.51219512195122 10.1 10 1 embryonic lethality before implantation, complete penetrance 1.79321767828182e-07 1.08795828651854e-05 1.24476019014868 0.512 10.1 10 1 oxidative stress 9.66817089404466e-06 0.000341128724807604 1.24259914815189 0.511111111111111 10.1 10 1 decreased osteoclast cell number 0.00158131453484053 0.0201203064215642 1.24259914815189 0.511111111111111 10.1 10 1 preweaning lethality, incomplete penetrance 6.34354491068187e-21 3.94489199133029e-18 1.24233496208872 0.511002444987775 10.1 10 1 reduced fertility 4.44609595254437e-08 3.25284225939827e-06 1.24182179491564 0.510791366906475 10.1 10 1 increased cellular sensitivity to gamma-irradiation 0.00128184193258074 0.0173095447453598 1.24144965772807 0.51063829787234 10.1 10 1 abnormal cell nucleus morphology 0.00128184193258074 0.0173095447453598 1.24144965772807 0.51063829787234 10.1 10 1 neuron degeneration 0.00128184193258074 0.0173095447453598 1.24144965772807 0.51063829787234 10.1 10 1 increased leukocyte cell number 2.44760685344897e-08 1.99620395014895e-06 1.24073618091329 0.510344827586207 10.1 10 1 absent kidney 0.00103974225567543 0.0149500512196107 1.24039400325721 0.510204081632653 10.1 10 1 increased fluid intake 0.00103974225567543 0.0149500512196107 1.24039400325721 0.510204081632653 10.1 10 1 increased monocyte cell number 3.5321290593481e-06 0.000147666740086191 1.23989784565591 0.51 10.1 10 1 respiratory failure 1.34794675937084e-08 1.2519927689048e-06 1.23973684087138 0.509933774834437 10.1 10 1 abnormal enzyme/coenzyme activity 7.42599257837654e-09 7.38886261548466e-07 1.23881388350784 0.509554140127389 10.1 10 1 increased sensitivity to xenobiotic induced morbidity/mortality 1.29442974989141e-06 6.17852733563221e-05 1.23768768906829 0.509090909090909 10.1 10 1 absent vitelline blood vessels 0.000452547649615028 0.00759980906431629 1.23691219552877 0.508771929824561 10.1 10 1 internal hemorrhage 0.000161567838894379 0.00339750616003518 1.23372919965762 0.507462686567164 10.1 10 1 decreased white adipose tissue amount 0.000161567838894379 0.00339750616003518 1.23372919965762 0.507462686567164 10.1 10 1 thymus hypoplasia 7.88225239625842e-08 5.29921698261968e-06 1.23320331338326 0.507246376811594 10.1 10 1 decreased bone marrow cell number 8.74453500245883e-05 0.00211961095075791 1.23223798789333 0.506849315068493 10.1 10 1 abnormal neural tube closure 3.15993211758034e-05 0.000930216703252202 1.23023173913414 0.506024096385542 10.1 10 1 increased grip strength 1.4051358901446e-05 0.000475547690712203 1.22894421245792 0.505494505494505 10.1 10 1 decreased B cell number 9.16957359543809e-11 1.30338938963727e-08 1.22738793021335 0.504854368932039 10.1 10 1 abnormal embryonic tissue morphology 5.11853342285172e-08 3.63781482552676e-06 1.22385541654712 0.503401360544218 10.1 10 1 abnormal brain morphology 1.26939954709956e-08 1.21447360515775e-06 1.22313634755972 0.503105590062112 10.1 10 1 abnormal abdominal fat pad morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 abnormal long bone epiphysis morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 abnormal tracheal cartilage morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 abnormal cochlear sensory epithelium morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 increased circulating creatine kinase level 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 increased mammary gland tumor incidence 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 increased bone volume 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 small gonad 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 brain inflammation 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 anencephaly 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal trachea morphology 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 decreased paired-pulse facilitation 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal hyoid bone morphology 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal thymocyte activation 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal heart right ventricle morphology 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 dilated vasculature 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 kidney atrophy 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal auchene hair morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 kidney hemorrhage 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 enlarged testis 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal prostate gland epithelium morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 fused cornea and lens 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 absent trophoblast giant cells 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal mammary gland physiology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 aneurysm 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 absent CD4-positive, alpha beta T cells 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 increased atrioventricular cushion size 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal hindlimb zeugopod morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal ear physiology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal plasma membrane morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal embryonic erythrocyte morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 decreased cochlear inner hair cell number 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal corneal endothelium morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 tachypnea 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 vascular smooth muscle hyperplasia 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal developmental vascular remodeling 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 protruding tongue 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 increased circulating fructosamine level 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal vibrissa follicle morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 decreased circulating lactate level 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 increased fatty acid oxidation 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 impaired balance 7.35536772477337e-06 0.000265166336454692 1.21558612319207 0.5 10.1 10 1 abnormal locomotor behavior 2.02002896773509e-05 0.0006483641364182 1.21558612319207 0.5 10.1 10 1 increased oxygen consumption 3.71148162442795e-05 0.00104710807443829 1.21558612319207 0.5 10.1 10 1 increased circulating creatinine level 3.71148162442795e-05 0.00104710807443829 1.21558612319207 0.5 10.1 10 1 small liver 8.37773109133526e-05 0.00205316316154645 1.21558612319207 0.5 10.1 10 1 pale liver 0.000126060300250186 0.00286369860157385 1.21558612319207 0.5 10.1 10 1 decreased circulating LDL cholesterol level 0.000352025696302474 0.00618843759400992 1.21558612319207 0.5 10.1 10 1 prenatal lethality 0.000432760608156552 0.00732307491693485 1.21558612319207 0.5 10.1 10 1 increased erythrocyte cell number 0.000532234794960687 0.00869242098465123 1.21558612319207 0.5 10.1 10 1 enhanced long term potentiation 0.000806141840023162 0.0123023179574087 1.21558612319207 0.5 10.1 10 1 impaired limb coordination 0.000992870621260238 0.0144854291518172 1.21558612319207 0.5 10.1 10 1 distended pericardium 0.00122352683062273 0.0169555598394097 1.21558612319207 0.5 10.1 10 1 abnormal skin condition 0.00122352683062273 0.0169555598394097 1.21558612319207 0.5 10.1 10 1 increased susceptibility to injury 0.00122352683062273 0.0169555598394097 1.21558612319207 0.5 10.1 10 1 vertebral transformation 0.00186144395765804 0.0225867948071115 1.21558612319207 0.5 10.1 10 1 increased grooming behavior 0.00538565290279328 0.0488934729770011 1.21558612319207 0.5 10.1 10 1 abnormal lumbar vertebrae morphology 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 abnormal depression-related behavior 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 decreased susceptibility to parasitic infection 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 abnormal auditory brainstem response waveform shape 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 gastrointestinal hemorrhage 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 increased metastatic potential 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 abnormal spleen marginal zone morphology 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 abnormal brain vasculature morphology 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 rib bifurcation 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 abnormal hormone level 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 increased bone resorption 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 decreased circulating progesterone level 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 corneal vascularization 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 abnormal kidney cortex morphology 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 thick skin 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 decreased circulating glycerol level 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 pulmonary edema 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 decreased Peyer's patch number 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 blindness 0.0250937792072342 0.14259747171786 1.21558612319207 0.5 10.1 10 1 abnormal thyroid cartilage morphology 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 abnormal metacarpal bone morphology 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 darkened coat color 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 decreased pulmonary respiratory rate 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 increased adipocyte glucose uptake 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 failure of tooth eruption 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal mouth morphology 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 poor circulation 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 increased intestinal adenocarcinoma incidence 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 bowed radius 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 increased cochlear outer hair cell number 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 small epididymis 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal level of surface class II molecules 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 dystonia 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal intestinal lipid absorption 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 loose skin 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 decreased liver cholesterol level 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal thoracic cage shape 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 dilated respiratory conducting tubes 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal pulmonary alveolus wall morphology 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 absent atrioventricular cushions 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal adrenal gland secretion 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal fluid regulation 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal prepulse inhibition 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 absent olfactory bulb 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal voluntary movement 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal vascular endothelial cell migration 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal decidualization 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 skeletal muscle necrosis 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal maternal decidual layer morphology 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal positive T cell selection 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 increased circulating growth hormone level 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 increased pulmonary respiratory rate 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 increased stomach tumor incidence 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal vitelline vein topology 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal rectum morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 amyloidosis 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 mesocardia 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal superior cervical ganglion morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal enteric nervous system morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 increased circulating parathyroid hormone level 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 increased fear-related response 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 delayed somite formation 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal rostral-caudal body axis extension 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 vestibular saccular macula degeneration 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 bowed ulna 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal thymus corticomedullary boundary morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 reduced cerebellar foliation 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 increased fibrosarcoma incidence 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal pulmonary valve cusp morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 prenatal growth retardation 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal vitelline vein connection 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 preweaning lethality, complete penetrance 4.17847852965491e-33 1.03939653425166e-29 1.21230075529155 0.498648648648649 10.1 10 1 abnormal cell cycle 3.12718128733504e-06 0.000131845143258405 1.20501580907736 0.495652173913044 10.1 10 1 decreased IgM level 1.91724412545357e-05 0.000619369449618929 1.20305430748906 0.494845360824742 10.1 10 1 increased neuron apoptosis 9.72106657464301e-05 0.00228124085890797 1.20057888710328 0.493827160493827 10.1 10 1 abnormal somite development 0.000119201230362192 0.00272030330757754 1.20019895707572 0.493670886075949 10.1 10 1 embryonic growth arrest 8.95819052575421e-11 1.30338938963727e-08 1.19966141415462 0.493449781659389 10.1 10 1 abnormal epidermal layer morphology 0.000331870664370124 0.0058756461040618 1.19796893300088 0.492753623188406 10.1 10 1 increased lymphocyte cell number 0.000331870664370124 0.0058756461040618 1.19796893300088 0.492753623188406 10.1 10 1 rib fusion 0.000407689211988571 0.00699397872290739 1.19744304672652 0.492537313432836 10.1 10 1 increased tumor incidence 1.97735701890295e-06 8.92768383434098e-05 1.19597989539865 0.491935483870968 10.1 10 1 decreased embryo size 1.53434420554654e-20 7.63336242259402e-18 1.19524158556542 0.49163179916318 10.1 10 1 abnormal cell morphology 5.39151100773207e-06 0.000204753948576084 1.19426005085537 0.491228070175439 10.1 10 1 abnormal craniofacial bone morphology 0.00114754312731377 0.0161728811852295 1.19426005085537 0.491228070175439 10.1 10 1 abnormal embryo turning 0.00141342013823528 0.0182643251629104 1.19348455731585 0.490909090909091 10.1 10 1 abnormal coat/ hair morphology 0.00174185998061158 0.0217732497576448 1.19265053596203 0.490566037735849 10.1 10 1 abnormal dendritic spine morphology 0.00214789556594599 0.0247929940616736 1.1917511011687 0.490196078431373 10.1 10 1 abnormal respiratory system physiology 0.00265027759156133 0.0289147610044246 1.19077824312693 0.489795918367347 10.1 10 1 increased neutrophil cell number 3.75690954870222e-07 2.07673611164373e-05 1.19043606547086 0.489655172413793 10.1 10 1 decreased hemoglobin content 5.59864378566129e-07 2.99497342297472e-05 1.18972258865607 0.48936170212766 10.1 10 1 increased respiratory quotient 0.00327243173423764 0.0335677275831593 1.18972258865607 0.48936170212766 10.1 10 1 abnormal behavior 2.59529177212496e-12 5.37982356930069e-10 1.1893504514685 0.489208633093525 10.1 10 1 decreased leukocyte cell number 8.3454164222139e-07 4.19378249500143e-05 1.18896744896159 0.489051094890511 10.1 10 1 irregular heartbeat 0.00404367660932675 0.0392149924588705 1.18857309823225 0.488888888888889 10.1 10 1 abnormal left-right axis patterning 0.00500077933804703 0.0457348361029109 1.18731667846667 0.488372093023256 10.1 10 1 abnormal homeostasis 0.00500077933804703 0.0457348361029109 1.18731667846667 0.488372093023256 10.1 10 1 abnormal blood circulation 0.00500077933804703 0.0457348361029109 1.18731667846667 0.488372093023256 10.1 10 1 perinatal lethality, complete penetrance 1.0440203966648e-09 1.20790731939707e-07 1.18705123767113 0.488262910798122 10.1 10 1 decreased exploration in new environment 0.000111543792013314 0.0025810714663546 1.1866435964494 0.488095238095238 10.1 10 1 hyperactivity 9.59524213843292e-16 3.67202535682337e-13 1.18609751103916 0.487870619946092 10.1 10 1 Leydig cell hyperplasia 0.00618995073105037 0.0540263243631151 1.185937681163 0.48780487804878 10.1 10 1 abnormal heart ventricle morphology 0.000205511291791148 0.00390236136130139 1.18441724823843 0.487179487179487 10.1 10 1 decreased trabecular bone volume 0.0076694166810579 0.0618401101916743 1.18441724823843 0.487179487179487 10.1 10 1 small seminiferous tubules 0.000309264120328991 0.00553449280085155 1.18273244418688 0.486486486486487 10.1 10 1 abnormal long bone metaphysis morphology 0.00951275048055005 0.0706554586523516 1.18273244418688 0.486486486486487 10.1 10 1 increased erythroid progenitor cell number 0.00951275048055005 0.0706554586523516 1.18273244418688 0.486486486486487 10.1 10 1 abnormal hepatocyte morphology 1.12658831670276e-05 0.000388265067225845 1.18273244418688 0.486486486486487 10.1 10 1 lethality throughout fetal growth and development, incomplete penetrance 3.02845847115242e-08 2.39152077682274e-06 1.18163120354983 0.486033519553073 10.1 10 1 impaired behavioral response to xenobiotic 0.0118132186880741 0.0834811974050693 1.18085509110087 0.485714285714286 10.1 10 1 decreased bone mineralization 0.0118132186880741 0.0834811974050693 1.18085509110087 0.485714285714286 10.1 10 1 prenatal lethality, complete penetrance 6.11099578788134e-12 1.08579300159677e-09 1.18060522756064 0.485611510791367 10.1 10 1 decreased circulating alanine transaminase level 0.000572206778312935 0.0092127143110254 1.17983359015701 0.485294117647059 10.1 10 1 decreased mean corpuscular hemoglobin 0.000572206778312935 0.0092127143110254 1.17983359015701 0.485294117647059 10.1 10 1 cardiovascular system phenotype 0.0146894905267845 0.0988906838575817 1.17875018006504 0.484848484848485 10.1 10 1 abnormal heart morphology 4.13685548828166e-10 5.14521401355031e-08 1.17875018006504 0.484848484848485 10.1 10 1 abnormal object recognition memory 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 decreased double-negative T cell number 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 small cranium 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 decreased heart weight 0.000232954638280723 0.00437339368093056 1.1705644149257 0.481481481481481 10.1 10 1 abnormal cochlea morphology 0.00243735010000927 0.0272069752481306 1.1705644149257 0.481481481481481 10.1 10 1 abnormal fetal cardiomyocyte proliferation 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 abnormal eye muscle morphology 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 abnormal skin appearance 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 decreased circulating fructosamine level 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 abnormal cardiovascular system physiology 2.92099529372471e-06 0.000124204714412653 1.16988739675628 0.481203007518797 10.1 10 1 decreased cell proliferation 3.88810350535851e-08 2.93080529381191e-06 1.1695909725848 0.481081081081081 10.1 10 1 absent corpus luteum 0.00300379254309715 0.0319997171347074 1.16883281076161 0.480769230769231 10.1 10 1 abnormal hair growth 0.00300379254309715 0.0319997171347074 1.16883281076161 0.480769230769231 10.1 10 1 prenatal lethality, incomplete penetrance 2.52283124295807e-12 5.37982356930069e-10 1.16760246043449 0.480263157894737 10.1 10 1 abnormal liver physiology 5.20905352695972e-05 0.00140842615742525 1.16696267826439 0.48 10.1 10 1 abnormal hindlimb morphology 0.00370407513643446 0.0364906411955672 1.16696267826439 0.48 10.1 10 1 spontaneous skin ulceration 0.0357191200466055 0.179860953675974 1.16696267826439 0.48 10.1 10 1 abnormal keratinocyte physiology 0.0357191200466055 0.179860953675974 1.16696267826439 0.48 10.1 10 1 small heart 0.00457054048869089 0.0430431607251859 1.1649367013924 0.479166666666667 10.1 10 1 thymus atrophy 0.00457054048869089 0.0430431607251859 1.1649367013924 0.479166666666667 10.1 10 1 decreased T cell number 4.16886826329721e-07 2.27913402306633e-05 1.1627345526185 0.478260869565217 10.1 10 1 abnormal blood vessel physiology 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 conjunctivitis 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 abnormal cardiovascular development 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 abnormal hepatocyte physiology 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 hypertension 0.00697379707433041 0.0585069822003268 1.16033220850152 0.477272727272727 10.1 10 1 abnormal circadian rhythm 0.00697379707433041 0.0585069822003268 1.16033220850152 0.477272727272727 10.1 10 1 abnormal lipid homeostasis 5.96447423595755e-06 0.000221442233760364 1.15948214827551 0.476923076923077 10.1 10 1 infertility 3.91348892441795e-05 0.00109379816848198 1.15878303332328 0.476635514018692 10.1 10 1 disheveled coat 0.00862455631658105 0.0674641001179099 1.15770106970673 0.476190476190476 10.1 10 1 small ears 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 abnormal hematopoietic system physiology 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 increased incidence of induced tumors 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 abnormal clavicle morphology 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 complete atrioventricular septal defect 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 increased bone ossification 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 increased muscle cell glucose uptake 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 gliosis 0.00146763116291437 0.0188182088543788 1.15770106970673 0.476190476190476 10.1 10 1 abnormal NK cell physiology 0.00180355706432558 0.022156544258372 1.15580319910066 0.475409836065574 10.1 10 1 abnormal pulmonary alveolus morphology 7.13711791224419e-05 0.00180239399052867 1.15540859234098 0.475247524752475 10.1 10 1 abnormal kidney morphology 2.36975310371923e-07 1.38700255188272e-05 1.15307026542791 0.474285714285714 10.1 10 1 abnormal reproductive system physiology 0.0132271383005311 0.0912690888282139 1.15160790618196 0.473684210526316 10.1 10 1 abnormal compact bone morphology 0.0132271383005311 0.0912690888282139 1.15160790618196 0.473684210526316 10.1 10 1 abnormal triglyceride level 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 irregular coat pigmentation 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 enlarged adrenal glands 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 altered susceptibility to infection 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 delayed sexual maturation 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 abnormal metatarsal bone morphology 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 abnormal response to novelty 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 oliguria 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 decreased eye pigmentation 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 abnormal behavioral response to xenobiotic 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 decreased susceptibility to weight gain 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 kidney cysts 0.000721210946720004 0.0111084348604707 1.14987876518169 0.472972972972973 10.1 10 1 small spleen 0.000194711989417804 0.00381280768369066 1.14879567686284 0.472527472527473 10.1 10 1 small ovary 0.000194711989417804 0.00381280768369066 1.14879567686284 0.472527472527473 10.1 10 1 decreased body size 7.79132400308012e-28 7.75236738306472e-25 1.14856132441958 0.472431077694236 10.1 10 1 abnormal uterus morphology 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 short radius 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 head tilt 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 narrow eye opening 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 premature death 1.10778293169586e-29 1.37780502129673e-26 1.14640642512423 0.471544715447154 10.1 10 1 abnormal extraembryonic tissue morphology 9.69428223385036e-05 0.00228124085890797 1.14408105712195 0.470588235294118 10.1 10 1 cochlear inner hair cell degeneration 0.00508734586575755 0.0462697361647967 1.14408105712195 0.470588235294118 10.1 10 1 decreased susceptibility to injury 0.00132905621354146 0.0174391300307673 1.14408105712195 0.470588235294118 10.1 10 1 abnormal endoderm development 0.0203731477420871 0.126065186588163 1.14408105712195 0.470588235294118 10.1 10 1 hydroureter 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 distended urinary bladder 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 abnormal touch/ nociception 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 increased hepatoma incidence 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 abnormal survival 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 delayed heart development 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 postnatal lethality 8.55965823945393e-07 4.25842997412833e-05 1.1423580434817 0.469879518072289 10.1 10 1 abnormal nervous system physiology 3.96736223977735e-05 0.0011026607342398 1.14159392438907 0.469565217391304 10.1 10 1 abnormal long bone hypertrophic chondrocyte zone 0.0062692345899978 0.0545269966525158 1.14116248299664 0.469387755102041 10.1 10 1 abnormal craniofacial development 0.0062692345899978 0.0545269966525158 1.14116248299664 0.469387755102041 10.1 10 1 increased exploration in new environment 0.000532902191018819 0.00869242098465123 1.14054994274812 0.469135802469136 10.1 10 1 abnormal osteoclast physiology 0.00200035782008852 0.0238080864950726 1.13961199049257 0.46875 10.1 10 1 kidney cortex cysts 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 polydipsia 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 failure of primitive streak formation 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 increased circulating follicle stimulating hormone level 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 abnormal lymphatic vessel morphology 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 neonatal lethality 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 abnormal heart atrium morphology 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 decreased IgG level 5.90041998406317e-05 0.0015288848656622 1.13892753884662 0.468468468468468 10.1 10 1 hunched posture 0.000652063043462028 0.0102334815180555 1.13865029261029 0.468354430379747 10.1 10 1 abnormal visceral yolk sac morphology 0.000652063043462028 0.0102334815180555 1.13865029261029 0.468354430379747 10.1 10 1 cleft secondary palate 0.000215557491762197 0.00407756091831532 1.13799551958407 0.468085106382979 10.1 10 1 abnormal T-helper 1 physiology 0.00773021483353946 0.0622294802538169 1.13799551958407 0.468085106382979 10.1 10 1 increased bone mineral content 7.1961164928025e-05 0.00180811512887335 1.13752095931735 0.467889908256881 10.1 10 1 pericardial effusion 0.00245516904128164 0.0273254272491637 1.13716121201839 0.467741935483871 10.1 10 1 double outlet right ventricle 8.7766805197212e-05 0.00211961095075791 1.13606179737577 0.467289719626168 10.1 10 1 increased susceptibility to parasitic infection 0.000321589848734617 0.00573444264320688 1.1345470483126 0.466666666666667 10.1 10 1 abnormal hair cycle 0.0315451367023928 0.163988563317037 1.1345470483126 0.466666666666667 10.1 10 1 disorganized myocardium 0.0315451367023928 0.163988563317037 1.1345470483126 0.466666666666667 10.1 10 1 abnormal enteric neuron morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 abnormal epidermis stratum spinosum morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 no suckling reflex 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 immune system phenotype 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 abnormal cerebral aqueduct morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 abnormal Muller cell morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 decreased thymocyte apoptosis 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 lactation failure 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 ostium primum atrial septal defect 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 decreased brown adipose tissue mass 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 small kidney 0.000392852391737719 0.00678625225310817 1.13270525115625 0.465909090909091 10.1 10 1 abnormal fertility/fecundity 0.00119576321354311 0.0168048643711214 1.13232679968576 0.465753424657534 10.1 10 1 ataxia 1.21556512643311e-07 7.8538136415646e-06 1.13133758000054 0.465346534653465 10.1 10 1 decreased body weight 1.1073748868689e-39 5.50919006217278e-36 1.13114314532897 0.465266558966074 10.1 10 1 embryonic lethality during organogenesis, incomplete penetrance 1.73477610914013e-08 1.46279849880884e-06 1.13102361027436 0.465217391304348 10.1 10 1 decreased oxygen consumption 0.0117756667326976 0.0834529088250291 1.13077778901588 0.465116279069767 10.1 10 1 abnormal ovary morphology 0.00146414180755129 0.0188182088543788 1.12998146662925 0.464788732394366 10.1 10 1 atelectasis 0.00146414180755129 0.0188182088543788 1.12998146662925 0.464788732394366 10.1 10 1 abnormal coat/hair pigmentation 7.91466965963053e-05 0.00194928126518128 1.12875854296407 0.464285714285714 10.1 10 1 increased triglyceride level 0.0393456380130616 0.197141475419371 1.12875854296407 0.464285714285714 10.1 10 1 hemorrhage 1.5685020094157e-08 1.3492361242088e-06 1.12765010576967 0.463829787234043 10.1 10 1 abnormal sternum morphology 0.00179309195908175 0.022156544258372 1.12750017223612 0.463768115942029 10.1 10 1 microcephaly 0.00179309195908175 0.022156544258372 1.12750017223612 0.463768115942029 10.1 10 1 short humerus 0.01454947049742 0.0983473039737292 1.12664079710485 0.463414634146341 10.1 10 1 abnormal embryo development 1.6197124737028e-05 0.000540810037360498 1.12620479060442 0.463235294117647 10.1 10 1 abnormal maxilla morphology 0.00559014558437426 0.0502910927346509 1.12554270665932 0.462962962962963 10.1 10 1 abnormal small intestine morphology 0.00559014558437426 0.0502910927346509 1.12554270665932 0.462962962962963 10.1 10 1 decreased compact bone thickness 0.00219637588957852 0.0252939121542897 1.1248707408643 0.462686567164179 10.1 10 1 decreased startle reflex 7.11287716608149e-05 0.00180239399052867 1.12207949833114 0.461538461538462 10.1 10 1 increased autoantibody level 0.017990899688651 0.114309994828913 1.12207949833114 0.461538461538462 10.1 10 1 eyelids open at birth 0.00687324871375214 0.057858565737592 1.12207949833114 0.461538461538462 10.1 10 1 kinked neural tube 0.00687324871375214 0.057858565737592 1.12207949833114 0.461538461538462 10.1 10 1 abnormal nasal bone morphology 0.0491657444900707 0.230319754084842 1.12207949833114 0.461538461538462 10.1 10 1 no spontaneous movement 0.0491657444900707 0.230319754084842 1.12207949833114 0.461538461538462 10.1 10 1 short hair 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 tight skin 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 pup cannibalization 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal intercostal muscle morphology 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal tail bud morphology 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased synaptic depression 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 vestibular hair cell degeneration 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased cochlear inner hair cell number 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased circulating thyroid-stimulating hormone level 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal vertebral arch development 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased circulating ammonia level 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 small pituitary gland 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased circulating thyroxine level 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased renin activity 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 orthokeratosis 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 empty decidua capsularis 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal aorta tunica media morphology 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal bone structure 4.26132594317154e-07 2.30435832253026e-05 1.12111051776263 0.461139896373057 10.1 10 1 abnormal skeleton morphology 8.65747855237279e-05 0.00211132136264974 1.12045329615965 0.460869565217391 10.1 10 1 neonatal lethality, complete penetrance 1.16785206910139e-14 3.63129002736214e-12 1.11961879767691 0.460526315789474 10.1 10 1 perinatal lethality, incomplete penetrance 5.46022743643905e-08 3.77286548559504e-06 1.11876952930952 0.460176991150442 10.1 10 1 decreased double-positive T cell number 0.000258950431822433 0.00478913902719928 1.11833923333671 0.46 10.1 10 1 kidney inflammation 0.00845437042081096 0.0664462762141146 1.11833923333671 0.46 10.1 10 1 short limbs 0.000640633201069365 0.0101179370645082 1.11778034316512 0.459770114942529 10.1 10 1 abnormal angiogenesis 0.00159913264034276 0.0201409743941904 1.1170250861765 0.459459459459459 10.1 10 1 abnormal intestine morphology 0.00159913264034276 0.0201409743941904 1.1170250861765 0.459459459459459 10.1 10 1 increased white adipose tissue amount 0.0222654819958184 0.132659608298439 1.1170250861765 0.459459459459459 10.1 10 1 impaired skeletal muscle contractility 0.0222654819958184 0.132659608298439 1.1170250861765 0.459459459459459 10.1 10 1 increased double-negative T cell number 0.00404166806703 0.0392149924588705 1.11594791637305 0.459016393442623 10.1 10 1 cardiac fibrosis 0.000781685431241539 0.0119658000628513 1.1154790306939 0.458823529411765 10.1 10 1 decreased circulating glucose level 2.17232111852216e-09 2.34941251405385e-07 1.11537651447014 0.458781362007168 10.1 10 1 curly tail 0.0104037854330266 0.0748238288091415 1.11428727959273 0.458333333333333 10.1 10 1 abnormal malleus morphology 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 abnormal startle reflex 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 decreased ovulation rate 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 abnormal osteoblast morphology 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 hypopigmentation 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 increased circulating total protein level 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 impaired fertilization 0.00239040961768362 0.0270218488391995 1.11139302691846 0.457142857142857 10.1 10 1 domed cranium 0.00239040961768362 0.0270218488391995 1.11139302691846 0.457142857142857 10.1 10 1 abnormal action potential 0.00239040961768362 0.0270218488391995 1.11139302691846 0.457142857142857 10.1 10 1 abnormal intestinal goblet cell morphology 0.0275815090507297 0.147142875886656 1.11139302691846 0.457142857142857 10.1 10 1 decreased glycogen level 0.0275815090507297 0.147142875886656 1.11139302691846 0.457142857142857 10.1 10 1 abnormal neural tube morphology 5.85442698549978e-06 0.000218990783856101 1.11053547057053 0.45679012345679 10.1 10 1 abnormal spermatogenesis 1.47455345463966e-06 6.85598452040402e-05 1.10988298204493 0.456521739130435 10.1 10 1 atrial septal defect 0.0128086624813166 0.0890114266836787 1.10988298204493 0.456521739130435 10.1 10 1 seizures 0.000139266932430359 0.00305060341147461 1.10895576150856 0.456140350877193 10.1 10 1 incomplete embryo turning 0.00607597676602115 0.0531247529190777 1.10895576150856 0.456140350877193 10.1 10 1 impaired natural killer cell mediated cytotoxicity 0.00607597676602115 0.0531247529190777 1.10895576150856 0.456140350877193 10.1 10 1 ventricular septal defect 3.44652328772315e-05 0.00099688682304783 1.10832852408689 0.455882352941176 10.1 10 1 impaired glucose tolerance 2.91445173700763e-08 2.33861248251822e-06 1.10775187032826 0.455645161290323 10.1 10 1 thin ventricular wall 0.000695297996390664 0.0108097110376361 1.10753402335278 0.455555555555556 10.1 10 1 increased blood urea nitrogen level 2.08781861976565e-05 0.000665826771367572 1.10660253973347 0.455172413793103 10.1 10 1 abnormal contextual conditioning behavior 0.0074524700108243 0.060286241144473 1.10507829381097 0.454545454545455 10.1 10 1 osteoporosis 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 omphalocele 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 decreased macrophage cell number 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 abnormal amino acid level 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 decreased sensitivity to induced morbidity/mortality 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 head tossing 0.0342017298586139 0.172920331348175 1.10507829381097 0.454545454545455 10.1 10 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0342017298586139 0.172920331348175 1.10507829381097 0.454545454545455 10.1 10 1 myeloid hyperplasia 0.0342017298586139 0.172920331348175 1.10507829381097 0.454545454545455 10.1 10 1 intestinal ulcer 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal oogenesis 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal chorion morphology 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 prolonged PR interval 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal circulating lipid level 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal limb posture 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal basement membrane morphology 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 cleft upper lip 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal cerebral cortex pyramidal cell morphology 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 increased adenoma incidence 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 impaired humoral immune response 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal ear position 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal enteric ganglia morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal food preference 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 vasculitis 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal fear/anxiety-related behavior 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal bronchiole morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal vestibular ganglion morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 decreased post-tetanic potentiation 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 allodynia 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 rectal hemorrhage 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal nerve fiber response 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 pulmonary hypertension 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 dilated renal glomerular capsule 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 pathological neovascularization 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 cyclopia 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal Bruch membrane morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 increased glycogen level 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal platelet aggregation 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal superovulation 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 enhanced behavioral response to addictive substance 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal aorta smooth muscle morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 increased number of Howell-Jolly bodies 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 aberrant origin of the right subclavian artery 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 shortened PR interval 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 increased subcutaneous adipose tissue amount 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 reduced sympathetic cervical ganglion size 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 reduced male fertility 1.49993232735453e-07 9.32770416073596e-06 1.10313101928443 0.45374449339207 10.1 10 1 short snout 0.000250135298922364 0.0046450902106009 1.10303185252614 0.453703703703704 10.1 10 1 kyphosis 1.86030392563391e-05 0.000608882370396624 1.10213141836081 0.453333333333333 10.1 10 1 increased anxiety-related response 3.72538953116737e-05 0.00104710807443829 1.10189821238993 0.453237410071942 10.1 10 1 decreased caudal vertebrae number 0.00437223976930354 0.0418372875963529 1.10162492414281 0.453125 10.1 10 1 azoospermia 1.12767087957527e-05 0.000388265067225845 1.10090818704188 0.452830188679245 10.1 10 1 abnormal pancreatic islet morphology 0.00914309478418177 0.0694456435897776 1.10090818704188 0.452830188679245 10.1 10 1 increased circulating bilirubin level 0.00914309478418177 0.0694456435897776 1.10090818704188 0.452830188679245 10.1 10 1 alopecia 0.00061661766788544 0.00976965890996836 1.10042533257387 0.452631578947368 10.1 10 1 impaired righting response 0.00061661766788544 0.00976965890996836 1.10042533257387 0.452631578947368 10.1 10 1 postnatal growth retardation 1.22725807243668e-17 5.08800742531042e-15 1.10038351674576 0.452614379084967 10.1 10 1 skin edema 0.0194439648207218 0.121524780129511 1.0998160162214 0.452380952380952 10.1 10 1 seminiferous tubule degeneration 0.00258143994041491 0.0282256345133279 1.09902307028324 0.452054794520548 10.1 10 1 distended abdomen 0.0112201405910335 0.0796293857922848 1.0964110130752 0.450980392156863 10.1 10 1 abnormal posture 0.00186596435491916 0.0225867948071115 1.09402751087286 0.45 10.1 10 1 decreased circulating phosphate level 0.0239761884948892 0.141832981881182 1.09402751087286 0.45 10.1 10 1 impaired ovarian folliculogenesis 0.0239761884948892 0.141832981881182 1.09402751087286 0.45 10.1 10 1 abnormal pancreatic beta cell morphology 0.0239761884948892 0.141832981881182 1.09402751087286 0.45 10.1 10 1 abnormal dopamine level 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 absent placental labyrinth 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 abnormal postnatal subventricular zone morphology 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 abnormal incus morphology 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 decreased circulating VLDL cholesterol level 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 abnormal circulating cytokine level 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 epidermal hyperplasia 0.00654268436445572 0.0566084429794212 1.09402751087286 0.45 10.1 10 1 abnormal incisor morphology 0.00654268436445572 0.0566084429794212 1.09402751087286 0.45 10.1 10 1 abnormal coat appearance 0.00384485629876988 0.0376538584377562 1.09226579185374 0.449275362318841 10.1 10 1 improved glucose tolerance 1.99190533791326e-06 8.92768383434098e-05 1.09154672286635 0.448979591836735 10.1 10 1 abnormal enzyme/coenzyme level 0.00800475932558084 0.063616098474065 1.08983583458599 0.448275862068966 10.1 10 1 abnormal microglial cell morphology 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 decreased granulocyte number 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 aphagia 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 absent long term depression 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 abnormal outer ear morphology 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 abnormal spatial learning 1.57564874163363e-05 0.000529652195245088 1.08880720236836 0.447852760736196 10.1 10 1 abnormal humoral immune response 0.000481502030272086 0.00803849865974372 1.08823900552433 0.447619047619048 10.1 10 1 persistence of hyaloid vascular system 0.0295822364158128 0.15639917765002 1.08762968917185 0.447368421052632 10.1 10 1 hepatic necrosis 0.0169104855814443 0.108563796290454 1.08626845051206 0.446808510638298 10.1 10 1 decreased litter size 3.14457687969183e-08 2.44441718382295e-06 1.08148231600718 0.444839857651246 10.1 10 1 abnormal CNS synaptic transmission 0.000859609521995418 0.0128741642256753 1.08052099839295 0.444444444444444 10.1 10 1 abnormal neuron morphology 0.000859609521995418 0.0128741642256753 1.08052099839295 0.444444444444444 10.1 10 1 cochlear outer hair cell degeneration 0.00410673311012437 0.0396718392677063 1.08052099839295 0.444444444444444 10.1 10 1 increased circulating corticosterone level 0.0207688826214396 0.128036172294501 1.08052099839295 0.444444444444444 10.1 10 1 cardiomyopathy 0.0207688826214396 0.128036172294501 1.08052099839295 0.444444444444444 10.1 10 1 lethality at weaning, complete penetrance 0.0207688826214396 0.128036172294501 1.08052099839295 0.444444444444444 10.1 10 1 heart right ventricle hypertrophy 0.0365218211975681 0.183549450277677 1.08052099839295 0.444444444444444 10.1 10 1 abnormal heart shape 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 right pulmonary isomerism 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal retinal rod cell morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 thick dermal layer 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal thymus cortex morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal bile duct morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal white adipose tissue morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 acidosis 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 decreased cellular sensitivity to gamma-irradiation 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 increased circulating renin level 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal body wall morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 decreased activity of thyroid 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal eye anterior chamber morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 increased susceptibility to autoimmune disorder 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal aerobic respiration 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 decreased susceptibility to hepatic steatosis 0.00698876940879331 0.0585338851999103 1.08052099839295 0.444444444444444 10.1 10 1 abnormal chondrocyte morphology 0.0119854541440278 0.084458405618326 1.08052099839295 0.444444444444444 10.1 10 1 abnormal heart valve morphology 0.0656834047928214 0.272539565341356 1.08052099839295 0.444444444444444 10.1 10 1 female infertility 9.02865374486234e-08 5.91020426061713e-06 1.07848994388469 0.443609022556391 10.1 10 1 decreased grip strength 1.30401079445504e-06 6.17852733563221e-05 1.07682058401489 0.442922374429224 10.1 10 1 thick epidermis 0.00500095494271026 0.0457348361029109 1.07666199482726 0.442857142857143 10.1 10 1 cleft palate 0.000163086597269677 0.00340905807317918 1.07639687244489 0.442748091603053 10.1 10 1 increased osteoclast cell number 0.00852878554182324 0.0669254070513732 1.07609263364544 0.442622950819672 10.1 10 1 decreased cardiac muscle contractility 0.000754535848722476 0.0115858513808467 1.07532618590068 0.442307692307692 10.1 10 1 abnormal female meiosis 0.0146676755281876 0.0988776229711831 1.07532618590068 0.442307692307692 10.1 10 1 decreased body temperature 0.0146676755281876 0.0988776229711831 1.07532618590068 0.442307692307692 10.1 10 1 abnormal organ of Corti morphology 0.0255147008070742 0.14278474298672 1.07423889956509 0.441860465116279 10.1 10 1 delayed endochondral bone ossification 0.0255147008070742 0.14278474298672 1.07423889956509 0.441860465116279 10.1 10 1 abnormal double-strand DNA break repair 0.0255147008070742 0.14278474298672 1.07423889956509 0.441860465116279 10.1 10 1 kinked tail 0.00091380136117891 0.0134501827569973 1.07257599105183 0.441176470588235 10.1 10 1 abnormal brown adipose tissue morphology 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 increased width of hypertrophic chondrocyte zone 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 abnormal direction of heart looping 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 abnormal skin physiology 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 abnormal colon morphology 0.0104076561881258 0.0748238288091415 1.07136404077945 0.440677966101695 10.1 10 1 decreased inflammatory response 0.00257857160060281 0.0282256345133279 1.07087348947873 0.44047619047619 10.1 10 1 delayed bone ossification 0.00435958425383283 0.0418372875963529 1.06971578840902 0.44 10.1 10 1 abnormal limb morphology 0.00435958425383283 0.0418372875963529 1.06971578840902 0.44 10.1 10 1 decreased circulating alkaline phosphatase level 0.0179513495131694 0.114204557324831 1.06971578840902 0.44 10.1 10 1 mandible hypoplasia 0.0818741546769245 0.290611309859591 1.06971578840902 0.44 10.1 10 1 abnormal feces composition 0.0818741546769245 0.290611309859591 1.06971578840902 0.44 10.1 10 1 impaired swimming 0.00741326103943521 0.0600667323635019 1.06824235068394 0.439393939393939 10.1 10 1 abnormal skin morphology 0.00741326103943521 0.0600667323635019 1.06824235068394 0.439393939393939 10.1 10 1 impaired coordination 3.15523110138954e-09 3.2702655686277e-07 1.06802942615719 0.439306358381503 10.1 10 1 abnormal developmental patterning 0.00312869605568566 0.0329772518581274 1.0673439130467 0.439024390243902 10.1 10 1 thick ventricular wall 0.0313536199711695 0.163988563317037 1.0673439130467 0.439024390243902 10.1 10 1 short ulna 0.0313536199711695 0.163988563317037 1.0673439130467 0.439024390243902 10.1 10 1 hemopericardium 0.0313536199711695 0.163988563317037 1.0673439130467 0.439024390243902 10.1 10 1 polydactyly 0.00133935101229029 0.0174391300307673 1.0667388428012 0.438775510204082 10.1 10 1 cardiac hypertrophy 0.00133935101229029 0.0174391300307673 1.0667388428012 0.438775510204082 10.1 10 1 decreased brain weight 0.0126995905304307 0.0886121499142956 1.06630361683515 0.43859649122807 10.1 10 1 neonatal lethality, incomplete penetrance 3.08454983919472e-07 1.76386614367744e-05 1.06597552341458 0.438461538461538 10.1 10 1 small testis 1.37557016918523e-07 8.77366870730323e-06 1.06584000656696 0.438405797101449 10.1 10 1 postnatal lethality, incomplete penetrance 4.75846306574365e-14 1.39255022071027e-11 1.06577797420713 0.438380281690141 10.1 10 1 anophthalmia 0.00224994077344424 0.025732081259506 1.06534514167395 0.438202247191011 10.1 10 1 abnormal urine homeostasis 0.00162088154225683 0.0203633476584034 1.06363785779306 0.4375 10.1 10 1 abnormal tooth morphology 0.00902384801728529 0.0687498374976942 1.06363785779306 0.4375 10.1 10 1 decreased eosinophil cell number 0.00902384801728529 0.0687498374976942 1.06363785779306 0.4375 10.1 10 1 abnormal intestinal epithelium morphology 0.0219712523635469 0.131220864956358 1.06363785779306 0.4375 10.1 10 1 abnormal kidney physiology 0.0219712523635469 0.131220864956358 1.06363785779306 0.4375 10.1 10 1 abnormal vertebral body morphology 0.0557786879772297 0.24644668977506 1.06363785779306 0.4375 10.1 10 1 pancreatic islet hyperplasia 0.0557786879772297 0.24644668977506 1.06363785779306 0.4375 10.1 10 1 abnormal bone marrow cell number 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 mixed cellular infiltration to dermis 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 reduced male mating frequency 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 abnormal extraembryonic endoderm formation 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 white spotting 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 large intestinal inflammation 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 increased pancreatic beta cell number 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 bowed tibia 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 abnormal wound healing 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased circulating growth hormone level 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased skeletal muscle weight 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased fibroblast apoptosis 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased circulating cholesterol level 1.88256397809721e-05 0.000612140901374746 1.0628075394029 0.437158469945355 10.1 10 1 abnormal skeletal muscle fiber morphology 0.00643511624418835 0.0558720825738867 1.06149774137899 0.436619718309859 10.1 10 1 abnormal learning/memory/conditioning 0.015494861214895 0.103333692418368 1.06087516205853 0.436363636363636 10.1 10 1 increased rib number 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 abnormal cornea morphology 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 increased circulating alanine transaminase level 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 increased urine protein level 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 abnormal lung development 0.00330057188601793 0.0337867183805333 1.0582749778378 0.435294117647059 10.1 10 1 abnormal axon morphology 0.00102028518061752 0.0147555778301517 1.05801014425976 0.435185185185185 10.1 10 1 hyperkeratosis 0.00781561003627632 0.062325639040374 1.05703141147137 0.434782608695652 10.1 10 1 abnormal forelimb morphology 0.0268921288830726 0.147020155157457 1.05703141147137 0.434782608695652 10.1 10 1 abnormal cranial nerve morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal nasal cavity morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal B cell morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal basicranium morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal vertebral artery topology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal blood vessel morphology 0.000169042578540054 0.00347515218279656 1.05630242429104 0.43448275862069 10.1 10 1 abnormal motor coordination/ balance 0.00170772394233815 0.0214003189247665 1.05596370297493 0.434343434343434 10.1 10 1 abnormal glucose homeostasis 2.8669048637041e-05 0.000854062975863945 1.05528905200191 0.434065934065934 10.1 10 1 enlarged kidney 0.0189031874319255 0.118293531413622 1.0550370125818 0.433962264150943 10.1 10 1 increased bone mineral density 0.000889404230373221 0.0131299289201981 1.05422513338781 0.433628318584071 10.1 10 1 male infertility 6.69939715826506e-12 1.14929313318513e-09 1.053669084914 0.433399602385686 10.1 10 1 abnormal heart tube morphology 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 arrested T cell differentiation 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 salivary gland inflammation 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 abnormal lactation 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 abnormal estrous cycle 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 emphysema 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 cachexia 0.00148603277479793 0.0189564437297942 1.05194952968545 0.432692307692308 10.1 10 1 malocclusion 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal vocalization 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal chromosome morphology 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal hair follicle development 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal calcium ion homeostasis 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal respiratory electron transport chain 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 cyanosis 2.19457762253049e-05 0.00069101415646134 1.05097550234314 0.432291666666667 10.1 10 1 abnormal skeleton development 0.00483596652242894 0.0445535804612667 1.05050652621537 0.432098765432099 10.1 10 1 abnormal astrocyte morphology 0.0329151825866346 0.169131267905512 1.04982437912042 0.431818181818182 10.1 10 1 cochlear hair cell degeneration 0.0329151825866346 0.169131267905512 1.04982437912042 0.431818181818182 10.1 10 1 lethality, incomplete penetrance 0.0329151825866346 0.169131267905512 1.04982437912042 0.431818181818182 10.1 10 1 abnormal eye morphology 0.000294268089036437 0.00538229317263335 1.04942686894279 0.431654676258993 10.1 10 1 decreased birth weight 0.00249033866911519 0.027530433830058 1.04924275896579 0.431578947368421 10.1 10 1 abnormal trophoblast layer morphology 0.0230577838678933 0.137051941150262 1.04874096902845 0.431372549019608 10.1 10 1 hydrops fetalis 0.00819560105287097 0.0649253427357214 1.04675471719317 0.430555555555556 10.1 10 1 abnormal placenta labyrinth morphology 0.00585066901203811 0.0513352351585354 1.04632729591216 0.430379746835443 10.1 10 1 abnormal rib morphology 0.000425115161599875 0.0072182523172675 1.04450363177985 0.42962962962963 10.1 10 1 increased sensitivity to induced morbidity/mortality 4.53898345842566e-05 0.00123395861779605 1.04381851882797 0.429347826086957 10.1 10 1 increased thermal nociceptive threshold 0.00362618669012622 0.0361528632933426 1.04193096273606 0.428571428571429 10.1 10 1 abnormal locomotor activation 0.00362618669012622 0.0361528632933426 1.04193096273606 0.428571428571429 10.1 10 1 abnormal seminal vesicle morphology 0.0197701345454831 0.123408305349784 1.04193096273606 0.428571428571429 10.1 10 1 myoclonus 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 small superior cervical ganglion 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 abnormal respiration 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 straub tail 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 failure of blastocyst to hatch from the zona pellucida 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 abnormal renal tubule epithelium morphology 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 translucent skin 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased vascular permeability 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 abnormal ventral body wall morphology 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 abnormal hair cuticle 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased CNS synapse formation 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 abnormal glucose tolerance 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased compact bone area 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 multiple persisting craniopharyngeal ducts 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased bone mineral density 1.23365320489014e-06 5.95866475177521e-05 1.04193096273606 0.428571428571429 10.1 10 1 abnormal nervous system electrophysiology 0.00505877560612983 0.0460941550192232 1.04193096273606 0.428571428571429 10.1 10 1 increased food intake 0.00505877560612983 0.0460941550192232 1.04193096273606 0.428571428571429 10.1 10 1 abnormal vibrissa morphology 0.0402858613340054 0.199425034961868 1.04193096273606 0.428571428571429 10.1 10 1 abnormal muscle morphology 0.0402858613340054 0.199425034961868 1.04193096273606 0.428571428571429 10.1 10 1 abnormal salivary gland morphology 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 abnormal anxiety-related response 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 hypoalgesia 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 dry skin 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 increased startle reflex 0.00437294262313639 0.0418372875963529 1.03802859957975 0.426966292134831 10.1 10 1 abnormal neurocranium morphology 0.00855328075957437 0.0670119240612323 1.03730015845723 0.426666666666667 10.1 10 1 abnormal long bone epiphyseal plate proliferative zone 0.0240356992261721 0.142016156354164 1.03549929012658 0.425925925925926 10.1 10 1 abnormal retinal pigment epithelium morphology 0.00736984465970087 0.0599100934346598 1.03324820471326 0.425 10.1 10 1 abnormal female reproductive system morphology 0.0493031275163969 0.230529191159844 1.03324820471326 0.425 10.1 10 1 head bobbing 0.0493031275163969 0.230529191159844 1.03324820471326 0.425 10.1 10 1 postnatal lethality, complete penetrance 1.38411260883948e-08 1.2519927689048e-06 1.03293328602849 0.424870466321244 10.1 10 1 increased mean corpuscular hemoglobin 0.0032661981385412 0.0335677275831593 1.03140640755691 0.424242424242424 10.1 10 1 dilated heart atrium 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 abnormal QRS complex 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 increased osteoblast cell number 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 abnormal middle ear ossicle morphology 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 abnormal excitatory postsynaptic currents 0.0088888993144235 0.0680389878130877 1.02857287347021 0.423076923076923 10.1 10 1 increased susceptibility to otitis media 0.105860322147284 0.341318925912338 1.02857287347021 0.423076923076923 10.1 10 1 abnormal ocular fundus morphology 0.105860322147284 0.341318925912338 1.02857287347021 0.423076923076923 10.1 10 1 weight loss 0.000138862672985178 0.00305060341147461 1.02803854989958 0.422857142857143 10.1 10 1 decreased anxiety-related response 0.00126956792643041 0.0173095447453598 1.02781265700793 0.422764227642276 10.1 10 1 increased circulating free fatty acid level 0.0124813465605453 0.0873343166507914 1.02725587875386 0.422535211267606 10.1 10 1 decreased liver weight 0.0124813465605453 0.0873343166507914 1.02725587875386 0.422535211267606 10.1 10 1 altered response to myocardial infarction 0.0417913248688927 0.203237381449405 1.0264949484733 0.422222222222222 10.1 10 1 abnormal ovarian follicle morphology 0.0417913248688927 0.203237381449405 1.0264949484733 0.422222222222222 10.1 10 1 small placenta 0.0417913248688927 0.203237381449405 1.0264949484733 0.422222222222222 10.1 10 1 decreased total body fat amount 2.16800454598439e-07 1.28402650193718e-05 1.02633319383283 0.422155688622754 10.1 10 1 abnormal renal glomerulus morphology 0.0024390574795309 0.0272069752481306 1.02599929663918 0.422018348623853 10.1 10 1 respiratory distress 0.000165869951827526 0.00343834587642475 1.02587036986152 0.421965317919075 10.1 10 1 increased sacral vertebrae number 0.0175924873124851 0.112064819948288 1.02565079144331 0.421875 10.1 10 1 hypoactivity 4.10567094050348e-08 3.04861387000072e-06 1.0253485070957 0.421750663129974 10.1 10 1 abnormal lipid level 0.00764697875075251 0.0617592845535613 1.02519311594512 0.421686746987952 10.1 10 1 small superior vagus ganglion 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 thin dermal layer 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 decreased grooming behavior 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 abnormal digestive system development 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 increased liver adenoma incidence 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 abnormal blastocyst morphology 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 decreased fertilization frequency 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 shortened RR interval 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 thin interventricular septum 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 abnormal gait 7.84775563925773e-07 4.0018819554443e-05 1.02282327517779 0.420711974110032 10.1 10 1 increased circulating triglyceride level 0.000596930797492979 0.00957977650815344 1.02276901399609 0.420689655172414 10.1 10 1 abnormal trabecular bone morphology 0.00182151288475863 0.022156544258372 1.02150094385888 0.420168067226891 10.1 10 1 decreased heart rate 0.00406627606062893 0.0393574385245698 1.02109234348134 0.42 10.1 10 1 reduced long term potentiation 0.00252510366454505 0.0277315468677961 1.02022406767906 0.419642857142857 10.1 10 1 lethargy 0.00566388839054931 0.0502956104192238 1.01952384525787 0.419354838709677 10.1 10 1 increased lung adenoma incidence 0.0881807277527319 0.295565976108634 1.01952384525787 0.419354838709677 10.1 10 1 abnormal retinal photoreceptor layer morphology 0.0881807277527319 0.295565976108634 1.01952384525787 0.419354838709677 10.1 10 1 preaxial polydactyly 0.0881807277527319 0.295565976108634 1.01952384525787 0.419354838709677 10.1 10 1 spleen hypoplasia 0.00350594745935413 0.035596099204667 1.01877694134193 0.419047619047619 10.1 10 1 abnormal liver morphology 0.000177765063168461 0.00362139229013276 1.0186475892671 0.418994413407821 10.1 10 1 abnormal male reproductive system morphology 0.0509210969133955 0.232710507300576 1.01770001011429 0.418604651162791 10.1 10 1 decreased circulating calcium level 0.0301744265467776 0.159191698907973 1.0166720303061 0.418181818181818 10.1 10 1 abnormal joint morphology 0.0301744265467776 0.159191698907973 1.0166720303061 0.418181818181818 10.1 10 1 limb grasping 0.000183602132838551 0.00371309191411298 1.01521478420437 0.417582417582418 10.1 10 1 abnormal craniofacial morphology 0.0041997180766633 0.04049146789031 1.01495540383027 0.41747572815534 10.1 10 1 insulin resistance 0.00140407797962645 0.0181908540329209 1.01298843599339 0.416666666666667 10.1 10 1 hydronephrosis 0.00949569528262587 0.0706554586523516 1.01298843599339 0.416666666666667 10.1 10 1 oligodactyly 0.0430821432879762 0.206288414684968 1.01298843599339 0.416666666666667 10.1 10 1 abnormal pharyngeal arch morphology 0.0738081392394673 0.290611309859591 1.01298843599339 0.416666666666667 10.1 10 1 abnormal adrenal gland morphology 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal body weight 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 curly vibrissae 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal nursing 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal sensory capabilities/reflexes/nociception 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal truncus arteriosus septation 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal mineral level 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal pilomotor reflex 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased litter size 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased growth rate 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal corticospinal tract morphology 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal AMPA-mediated synaptic currents 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased synaptic depression 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 small thyroid gland 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal alisphenoid bone morphology 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 loss of dopaminergic neurons 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased left ventricle systolic pressure 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased hepatocyte proliferation 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 stria vascularis degeneration 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 absent cochlear hair cells 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased cochlear nerve compound action potential 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased prostaglandin level 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased or absent threshold for auditory brainstem response 4.39308330988979e-06 0.000176040463578132 1.00948328569584 0.41522491349481 10.1 10 1 atrioventricular septal defect 0.0365254182462112 0.183549450277677 1.00916583812172 0.415094339622642 10.1 10 1 abnormal cholesterol homeostasis 0.0620173620275996 0.266120168205467 1.00804702898855 0.414634146341463 10.1 10 1 glomerulosclerosis 0.031022513695184 0.163492590713496 1.00600230884861 0.413793103448276 10.1 10 1 focal hair loss 0.108493154047331 0.349129004777148 1.00600230884861 0.413793103448276 10.1 10 1 increased double-positive T cell number 0.108493154047331 0.349129004777148 1.00600230884861 0.413793103448276 10.1 10 1 abnormal sleep pattern 0.0522759442663215 0.235786783975476 1.0041798408978 0.41304347826087 10.1 10 1 increased circulating aspartate transaminase level 0.0263905273554722 0.146067271983839 1.00334092707917 0.412698412698413 10.1 10 1 abnormal response to novel object 0.0441820458970801 0.211351613786513 1.0010709249817 0.411764705882353 10.1 10 1 lung hemorrhage 0.0902684266076045 0.300153190420097 1.0010709249817 0.411764705882353 10.1 10 1 impaired synaptic plasticity 0.0902684266076045 0.300153190420097 1.0010709249817 0.411764705882353 10.1 10 1 increased susceptibility to weight gain 0.0902684266076045 0.300153190420097 1.0010709249817 0.411764705882353 10.1 10 1 abnormal heart rate 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal glutamate-mediated receptor currents 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal involuntary movement 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal tarsal bone morphology 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 increased circulating magnesium level 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 common atrium 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal electroretinogram waveform feature 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 decreased body fat mass 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal seminiferous tubule morphology 0.00131603847529501 0.0174391300307673 0.999111882075674 0.410958904109589 10.1 10 1 absent gastric milk in neonates 0.0163745148988317 0.107113440110536 0.997403998516571 0.41025641025641 10.1 10 1 increased embryonic tissue cell apoptosis 0.0163745148988317 0.107113440110536 0.997403998516571 0.41025641025641 10.1 10 1 acanthosis 0.0754894787783314 0.290611309859591 0.997403998516571 0.41025641025641 10.1 10 1 increased vascular permeability 0.0754894787783314 0.290611309859591 0.997403998516571 0.41025641025641 10.1 10 1 abnormal circulating hormone level 0.0754894787783314 0.290611309859591 0.997403998516571 0.41025641025641 10.1 10 1 no abnormal phenotype detected 2.13298898535766e-27 1.76860336702573e-24 0.996290182812175 0.409798270893372 10.1 10 1 short tail 0.0139965591988522 0.0947386149854281 0.995901884060973 0.409638554216867 10.1 10 1 abnormal motor capabilities/coordination/movement 0.0025004697841547 0.027530433830058 0.994570464429876 0.409090909090909 10.1 10 1 hyperglycemia 0.0119749060811619 0.084458405618326 0.994570464429876 0.409090909090909 10.1 10 1 renal interstitial fibrosis 0.0633867299088454 0.266120168205467 0.994570464429876 0.409090909090909 10.1 10 1 abnormal basisphenoid bone morphology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal enterocyte morphology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal tail movements 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 increased activated T cell number 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 testis hypoplasia 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 increased myocardial infarction size 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 decreased cardiac output 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal female reproductive system physiology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal occipital bone morphology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 rough coat 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal epidermis stratum corneum morphology 0.0534007368646435 0.239443316835552 0.992315202605772 0.408163265306122 10.1 10 1 axon degeneration 0.045112100072488 0.213982060876589 0.990477581860206 0.407407407407407 10.1 10 1 abnormal trigeminal nerve morphology 0.133481952828477 0.402359554617639 0.990477581860206 0.407407407407407 10.1 10 1 abnormal trigeminal ganglion morphology 0.133481952828477 0.402359554617639 0.990477581860206 0.407407407407407 10.1 10 1 thin epidermis 0.133481952828477 0.402359554617639 0.990477581860206 0.407407407407407 10.1 10 1 abnormal diaphragm morphology 0.110350544441233 0.354647260074377 0.987663725093557 0.40625 10.1 10 1 bradykinesia 0.110350544441233 0.354647260074377 0.987663725093557 0.40625 10.1 10 1 perimembraneous ventricular septal defect 0.0275465841117714 0.147142875886656 0.986562650706608 0.405797101449275 10.1 10 1 increased brown adipose tissue amount 0.0918247383190742 0.304146520064843 0.985610370155733 0.405405405405405 10.1 10 1 abnormal cartilage morphology 0.0767947824992438 0.290611309859591 0.984045909250724 0.404761904761905 10.1 10 1 decreased bone trabecula number 0.064483448018951 0.268456195727432 0.982814312368057 0.404255319148936 10.1 10 1 deafness 0.0106660352270107 0.0765707435128112 0.982291816720865 0.404040404040404 10.1 10 1 decreased IgA level 0.0543240405480947 0.240660820771835 0.981819561039749 0.403846153846154 10.1 10 1 decreased kidney weight 0.0543240405480947 0.240660820771835 0.981819561039749 0.403846153846154 10.1 10 1 increased hepatocellular carcinoma incidence 0.0458909543064662 0.21722882747352 0.980999327488338 0.403508771929825 10.1 10 1 abnormal facial morphology 0.0458909543064662 0.21722882747352 0.980999327488338 0.403508771929825 10.1 10 1 increased eosinophil cell number 0.0388572849294941 0.195070628177834 0.980311389671024 0.403225806451613 10.1 10 1 abnormal cranium morphology 0.00365815087649458 0.0363259493224761 0.979726129139878 0.402985074626866 10.1 10 1 abnormal femur morphology 0.0329675154203992 0.169131267905512 0.979726129139878 0.402985074626866 10.1 10 1 polyuria 0.0238498480442503 0.14159068498824 0.978783631661148 0.402597402597403 10.1 10 1 abnormal response/metabolism to endogenous compounds 0.0203283613620329 0.125944704577975 0.978398586959471 0.402439024390244 10.1 10 1 abnormal myocardial fiber morphology 0.0126729211934286 0.0885502569344201 0.977481624834861 0.402061855670103 10.1 10 1 enlarged liver 0.012864163976998 0.0890114266836787 0.972468898553656 0.4 10.1 10 1 abnormal circulating protein level 0.065345347870639 0.271363193369306 0.972468898553656 0.4 10.1 10 1 decreased oocyte number 0.065345347870639 0.271363193369306 0.972468898553656 0.4 10.1 10 1 decreased respiratory quotient 0.065345347870639 0.271363193369306 0.972468898553656 0.4 10.1 10 1 diaphragmatic hernia 0.164197440196587 0.453844756307973 0.972468898553656 0.4 10.1 10 1 increased cellular sensitivity to ionizing radiation 0.164197440196587 0.453844756307973 0.972468898553656 0.4 10.1 10 1 increased liver glycogen level 0.164197440196587 0.453844756307973 0.972468898553656 0.4 10.1 10 1 abnormal cell proliferation 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal lens epithelium morphology 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 enhanced behavioral response to xenobiotic 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal sperm mitochondrial sheath morphology 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal heart electrocardiography waveform feature 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal metabolism 0.0777836666021475 0.290611309859591 0.972468898553656 0.4 10.1 10 1 abnormal testis morphology 0.00808519618535627 0.0641528724436164 0.972468898553656 0.4 10.1 10 1 abnormal long bone epiphyseal plate morphology 0.0465350957221849 0.220068537279344 0.972468898553656 0.4 10.1 10 1 abnormal rostral-caudal axis patterning 0.0550705490896286 0.243750873417173 0.972468898553656 0.4 10.1 10 1 abnormal embryonic epiblast morphology 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 abnormal hippocampus pyramidal cell morphology 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 increased red blood cell distribution width 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 decreased bone volume 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 abnormal optic cup morphology 0.134817331569617 0.402359554617639 0.972468898553656 0.4 10.1 10 1 decreased chondrocyte number 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 macrocytosis 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal pup retrieval 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal seizure response to electrical stimulation 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal respiratory system morphology 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal cricoid cartilage morphology 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 altered righting response 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal glial cell morphology 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal ear development 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal placenta size 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal microglial cell activation 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 decreased trabecular bone mass 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 heterochrony 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 increased body weight 0.000424400360001465 0.0072182523172675 0.965956830036556 0.397321428571429 10.1 10 1 abnormal hair follicle morphology 0.0470590991229297 0.222335249892284 0.964750891422278 0.396825396825397 10.1 10 1 abnormal placenta development 0.0660043864337058 0.273643185423072 0.963294663661641 0.39622641509434 10.1 10 1 overriding aortic valve 0.0785049924978654 0.290611309859591 0.962339014193722 0.395833333333333 10.1 10 1 abnormal lymph node morphology 0.0785049924978654 0.290611309859591 0.962339014193722 0.395833333333333 10.1 10 1 abnormal intestinal mucosa morphology 0.0937121923053751 0.309368385347871 0.961161120663497 0.395348837209302 10.1 10 1 increased circulating alkaline phosphatase level 0.00293931077196204 0.0316516690270804 0.960463109682624 0.395061728395062 10.1 10 1 abnormal axial skeleton morphology 0.0341840500289463 0.172920331348175 0.959673255151634 0.394736842105263 10.1 10 1 abnormal frontal bone morphology 0.112364536439913 0.356662865835777 0.959673255151634 0.394736842105263 10.1 10 1 corneal opacity 0.0402492268650078 0.199425034961868 0.958772153503605 0.394366197183099 10.1 10 1 decreased body length 0.000161851047221776 0.00339750616003518 0.958272272297399 0.394160583941606 10.1 10 1 abnormal tooth development 0.135488023833393 0.402359554617639 0.957734521302843 0.393939393939394 10.1 10 1 abnormal epidermis stratum basale morphology 0.135488023833393 0.402359554617639 0.957734521302843 0.393939393939394 10.1 10 1 decreased rib number 0.0249941895394707 0.14259747171786 0.956078973297134 0.393258426966292 10.1 10 1 abnormal jaw morphology 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 increased circulating luteinizing hormone level 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 absent corpus callosum 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 enhanced coordination 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 enlarged heart 0.000606483789947804 0.00970179053051552 0.953606355262745 0.392241379310345 10.1 10 1 abnormal cued conditioning behavior 0.078999091079387 0.290611309859591 0.953400880934957 0.392156862745098 10.1 10 1 hydroencephaly 0.013554323019929 0.0927892798041066 0.951328270324229 0.391304347826087 10.1 10 1 abnormal pulmonary artery morphology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal innervation pattern to muscle 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 blistering 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal circulating insulin level 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 failure of embryo implantation 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 pancreas inflammation 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal cochlear ganglion morphology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal sacral vertebrae morphology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 increased susceptibility to age related obesity 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 decreased epididymis weight 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal regulatory T cell physiology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal lens development 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 obese 0.0407803491681139 0.201571040584227 0.947209966123691 0.38961038961039 10.1 10 1 decreased bone mineral content 0.00148484934223642 0.0189564437297942 0.946754576716901 0.389423076923077 10.1 10 1 abnormal osteoblast physiology 0.0792994777544811 0.290611309859591 0.945455873593833 0.388888888888889 10.1 10 1 impaired wound healing 0.135648158444341 0.402359554617639 0.945455873593833 0.388888888888889 10.1 10 1 abnormal reflex 0.135648158444341 0.402359554617639 0.945455873593833 0.388888888888889 10.1 10 1 abnormal retinal blood vessel morphology 0.135648158444341 0.402359554617639 0.945455873593833 0.388888888888889 10.1 10 1 underdeveloped hair follicles 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 cortical renal glomerulopathies 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal radius morphology 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal mammary gland morphology 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 absent spleen 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 eye inflammation 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal redox activity 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 increased effector memory CD4-positive, alpha-beta T cell number 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal metanephric mesenchyme morphology 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 decreased fluid intake 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 increased total body fat amount 0.0101562812369842 0.0739757758551177 0.943439976208771 0.388059701492537 10.1 10 1 absent mature ovarian follicles 0.164272028717125 0.453844756307973 0.941098934084184 0.387096774193548 10.1 10 1 autoimmune response 0.164272028717125 0.453844756307973 0.941098934084184 0.387096774193548 10.1 10 1 teratozoospermia 0.034970190866161 0.176446956956543 0.939316549739327 0.386363636363636 10.1 10 1 muscular atrophy 0.112806001962449 0.356662865835777 0.939316549739327 0.386363636363636 10.1 10 1 abnormal blood homeostasis 0.0187652964576748 0.117578526293366 0.938347182814932 0.385964912280702 10.1 10 1 failure of heart looping 0.135411447478403 0.402359554617639 0.935066248609285 0.384615384615385 10.1 10 1 abnormal tectorial membrane morphology 0.200658138977402 0.49823504793006 0.935066248609285 0.384615384615385 10.1 10 1 abnormal nerve conduction 0.200658138977402 0.49823504793006 0.935066248609285 0.384615384615385 10.1 10 1 abnormal membranous labyrinth morphology 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 absent myocardial trabeculae 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 increased foot pad pigmentation 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal grip strength 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal digestion 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal soleus morphology 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 anal atresia 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 absent lateral semicircular canal 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal insulin secretion 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 small otic vesicle 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 decreased endocochlear potential 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal hair follicle inner root sheath morphology 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 muscular ventricular septal defect 0.0794267860878902 0.290611309859591 0.931949361113921 0.383333333333333 10.1 10 1 increased systemic arterial blood pressure 0.11261475436328 0.356662865835777 0.931087243296054 0.382978723404255 10.1 10 1 abnormal retinal photoreceptor morphology 0.16348110783031 0.453102234794313 0.929565858911583 0.382352941176471 10.1 10 1 overexpanded pulmonary alveoli 0.16348110783031 0.453102234794313 0.929565858911583 0.382352941176471 10.1 10 1 abnormal vision 0.16348110783031 0.453102234794313 0.929565858911583 0.382352941176471 10.1 10 1 increased circulating calcium level 0.0942644042827724 0.310573120070724 0.928265766801217 0.381818181818182 10.1 10 1 abnormal T-helper 2 physiology 0.0942644042827724 0.310573120070724 0.928265766801217 0.381818181818182 10.1 10 1 increased heart weight 0.0139430823156758 0.094505224142353 0.926993734232802 0.381294964028777 10.1 10 1 increased circulating insulin level 0.00890178725107179 0.0680389878130877 0.926884418933954 0.38125 10.1 10 1 abnormal retina morphology 0.00318945264251644 0.0334637270396888 0.926160855765387 0.380952380952381 10.1 10 1 arrest of spermatogenesis 0.0482815562461616 0.226604473891183 0.926160855765387 0.380952380952381 10.1 10 1 abnormal reproductive system morphology 0.13486343603499 0.402359554617639 0.926160855765387 0.380952380952381 10.1 10 1 decreased cochlear outer hair cell number 0.248071004061806 0.558314124616683 0.926160855765387 0.380952380952381 10.1 10 1 abnormal stapes morphology 0.248071004061806 0.558314124616683 0.926160855765387 0.380952380952381 10.1 10 1 decreased vocalization 0.248071004061806 0.558314124616683 0.926160855765387 0.380952380952381 10.1 10 1 abnormal digestive system physiology 0.112214713238811 0.356662865835777 0.923845453625974 0.38 10.1 10 1 abnormal spermiogenesis 0.0939618444648945 0.309986854252553 0.922168783111226 0.379310344827586 10.1 10 1 abnormal middle ear morphology 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 abnormal parietal bone morphology 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 decreased retinal photoreceptor cell number 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 polychromatophilia 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 increased retinal apoptosis 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 abnormal breathing pattern 0.162323283737982 0.452237011694502 0.919903012145351 0.378378378378378 10.1 10 1 skin inflammation 0.162323283737982 0.452237011694502 0.919903012145351 0.378378378378378 10.1 10 1 abnormal excitatory postsynaptic potential 0.0565931857414526 0.248062642346896 0.919101702901322 0.378048780487805 10.1 10 1 abnormal ectoderm development 0.134069562716918 0.402359554617639 0.918442848634009 0.377777777777778 10.1 10 1 albuminuria 0.134069562716918 0.402359554617639 0.918442848634009 0.377777777777778 10.1 10 1 abnormal mesoderm development 0.111643186284316 0.356662865835777 0.917423489201563 0.377358490566038 10.1 10 1 abnormal maternal nurturing 0.0935360195246323 0.308991830766963 0.916671502735004 0.377049180327869 10.1 10 1 abnormal long bone morphology 0.0935360195246323 0.308991830766963 0.916671502735004 0.377049180327869 10.1 10 1 abnormal male meiosis 0.0935360195246323 0.308991830766963 0.916671502735004 0.377049180327869 10.1 10 1 decreased spleen weight 0.0787370817904897 0.290611309859591 0.91609388994185 0.376811594202899 10.1 10 1 circling 0.0563925217851204 0.247777856714323 0.915264845697559 0.376470588235294 10.1 10 1 abnormal vertebrae morphology 0.0348291054672216 0.175913502232921 0.914477633961007 0.376146788990826 10.1 10 1 abnormal skin pigmentation 0.160890088193671 0.449931528253801 0.911689592394053 0.375 10.1 10 1 abnormal digestive system morphology 0.244277212002757 0.558314124616683 0.911689592394053 0.375 10.1 10 1 abnormal foregut morphology 0.244277212002757 0.558314124616683 0.911689592394053 0.375 10.1 10 1 increased stereotypic behavior 0.244277212002757 0.558314124616683 0.911689592394053 0.375 10.1 10 1 decreased circulating HDL cholesterol level 0.0253952482295526 0.14259747171786 0.911689592394053 0.375 10.1 10 1 absent mandible 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 vasculature congestion 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 delayed hair appearance 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 abnormal meiosis 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 abnormal olfaction 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 decreased circulating prolactin level 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 impaired behavioral response to addictive substance 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 impaired somite development 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 decreased midbrain size 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 maternal effect 0.0923876482505031 0.305807418527114 0.907153823277664 0.373134328358209 10.1 10 1 abnormal gastrulation 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 abnormal cervical vertebrae morphology 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 abnormal gluconeogenesis 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 increased kidney weight 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 holoprosencephaly 0.19413856213324 0.49823504793006 0.903006834371252 0.371428571428571 10.1 10 1 impaired adaptive thermogenesis 0.19413856213324 0.49823504793006 0.903006834371252 0.371428571428571 10.1 10 1 abnormal neuronal precursor proliferation 0.130668897184219 0.397844408501524 0.90043416532746 0.37037037037037 10.1 10 1 rectal prolapse 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 wrinkled skin 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 decreased susceptibility to pharmacologically induced seizures 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 decreased bone ossification 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 delayed wound healing 0.157452227145327 0.442806574362918 0.898476699750661 0.369565217391304 10.1 10 1 abnormal circulating amino acid level 0.129303261747058 0.393927573295538 0.895695038141526 0.368421052631579 10.1 10 1 hyporesponsive to tactile stimuli 0.191465886328522 0.49823504793006 0.895695038141526 0.368421052631579 10.1 10 1 abnormal nail morphology 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 short vibrissae 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal long term depression 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 decreased chemically-elicited antinociception 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal nasal septum morphology 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 osteoarthritis 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal cochlear inner hair cell morphology 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 increased circulating VLDL cholesterol level 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal retinal pigmentation 0.0754700571248701 0.290611309859591 0.894224274532098 0.367816091954023 10.1 10 1 increased circulating LDL cholesterol level 0.155537793014956 0.438215131485303 0.893083682345195 0.36734693877551 10.1 10 1 microphthalmia 0.027697295974749 0.1472158626863 0.88984082220596 0.366013071895425 10.1 10 1 increased tumor growth/size 0.188667805875492 0.49823504793006 0.889453260872247 0.365853658536585 10.1 10 1 lethality at weaning, incomplete penetrance 0.188667805875492 0.49823504793006 0.889453260872247 0.365853658536585 10.1 10 1 abnormal snout morphology 0.153536317182514 0.435486418462376 0.888312936178821 0.365384615384615 10.1 10 1 increased circulating cholesterol level 0.0228021400485921 0.135694553518835 0.884062635048779 0.363636363636364 10.1 10 1 embryonic lethality, incomplete penetrance 0.185788418978092 0.49823504793006 0.884062635048779 0.363636363636364 10.1 10 1 dextrocardia 0.231560288110811 0.558314124616683 0.884062635048779 0.363636363636364 10.1 10 1 single kidney 0.231560288110811 0.558314124616683 0.884062635048779 0.363636363636364 10.1 10 1 diarrhea 0.231560288110811 0.558314124616683 0.884062635048779 0.363636363636364 10.1 10 1 abnormal facial nerve morphology 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 intracerebral hemorrhage 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 increased coping response 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 aphakia 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 parakeratosis 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 abnormal social investigation 0.102386208650739 0.334452651370603 0.881299939314251 0.3625 10.1 10 1 pulmonary hypoplasia 0.182860128388488 0.493345519920134 0.879360174224051 0.361702127659574 10.1 10 1 abnormal digit morphology 0.121606105693611 0.37507152872022 0.877923311194273 0.361111111111111 10.1 10 1 abnormal systemic arterial blood pressure 0.227198355522618 0.550030082104634 0.877923311194273 0.361111111111111 10.1 10 1 abnormal limb bone morphology 0.227198355522618 0.550030082104634 0.877923311194273 0.361111111111111 10.1 10 1 testicular atrophy 0.179907025389037 0.485905239582224 0.875222008698291 0.36 10.1 10 1 abnormal axon extension 0.179907025389037 0.485905239582224 0.875222008698291 0.36 10.1 10 1 ruffled hair 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 abnormal thyroid gland morphology 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 decreased placenta weight 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 abnormal vertebrae development 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 small lens 0.222856372084589 0.54004405802281 0.872728498701999 0.358974358974359 10.1 10 1 abnormal neuron differentiation 0.0784562651416265 0.290611309859591 0.86827580228005 0.357142857142857 10.1 10 1 abnormal interparietal bone morphology 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 midline facial cleft 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal vasoconstriction 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 megacephaly 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 irregularly shaped pupil 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal sagittal suture morphology 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 enlarged stomach 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal pancreas development 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 split sternum 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal renal reabsorbtion 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal thoracic vertebrae morphology 0.171058583160215 0.471477258294774 0.865332494475711 0.355932203389831 10.1 10 1 decreased insulin secretion 0.111735120377836 0.356662865835777 0.864416798714361 0.355555555555556 10.1 10 1 abnormal autopod morphology 0.214322960363567 0.519618288405822 0.864416798714361 0.355555555555556 10.1 10 1 abnormal podocyte morphology 0.275302458034426 0.558314124616683 0.862674022910502 0.354838709677419 10.1 10 1 abnormal inhibitory postsynaptic currents 0.162424627854309 0.452237011694502 0.858060792841461 0.352941176470588 10.1 10 1 increased incidence of corneal inflammation 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 decreased vasoconstriction 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 nephrocalcinosis 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal duodenum morphology 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal testis development 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal embryonic-extraembryonic boundary morphology 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 coloboma 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal cell cytoskeleton morphology 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 increased circulating HDL cholesterol level 0.103669056871285 0.338083354080179 0.856698791582983 0.352380952380952 10.1 10 1 decreased circulating chloride level 0.262339019405962 0.558314124616683 0.854195654134968 0.351351351351351 10.1 10 1 increased insulin secretion 0.262339019405962 0.558314124616683 0.854195654134968 0.351351351351351 10.1 10 1 increased mammary adenocarcinoma incidence 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 abnormal hair texture 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 spleen atrophy 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 abnormal male reproductive system physiology 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 nuclear cataracts 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 decreased muscle cell glucose uptake 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 abnormal tail morphology 0.186911595365399 0.49823504793006 0.847226691921746 0.348484848484849 10.1 10 1 abnormal Wolffian duct morphology 0.347325506272007 0.606935157605632 0.845625129177092 0.347826086956522 10.1 10 1 abnormal eye electrophysiology 0.106952507843495 0.344617050855819 0.843877969819289 0.347107438016529 10.1 10 1 decreased circulating creatinine level 0.239175862586587 0.558314124616683 0.843467922214906 0.346938775510204 10.1 10 1 small seminal vesicle 0.33626181905531 0.588221712306669 0.841559623748356 0.346153846153846 10.1 10 1 abnormal Mullerian duct morphology 0.33626181905531 0.588221712306669 0.841559623748356 0.346153846153846 10.1 10 1 abnormal head morphology 0.228774298671764 0.553575941581724 0.83985950329634 0.345454545454545 10.1 10 1 abnormal circulating glucose level 0.326036670575633 0.584179409504396 0.838335257373842 0.344827586206897 10.1 10 1 decreased bone strength 0.326036670575633 0.584179409504396 0.838335257373842 0.344827586206897 10.1 10 1 increased fatty acid level 0.316514502142495 0.584179409504396 0.835715459694548 0.34375 10.1 10 1 abnormal serotonin level 0.316514502142495 0.584179409504396 0.835715459694548 0.34375 10.1 10 1 scaly skin 0.29125136503829 0.558314124616683 0.830156376814097 0.341463414634146 10.1 10 1 short femur 0.181927471893709 0.49109559016343 0.82880872035823 0.340909090909091 10.1 10 1 increased circulating glucose level 0.117988641562382 0.364139883233779 0.827633105152048 0.340425531914894 10.1 10 1 increased body length 0.269708293870173 0.558314124616683 0.826598563770608 0.34 10.1 10 1 increased hemoglobin content 0.250892730144284 0.558314124616683 0.824126185214963 0.338983050847458 10.1 10 1 abnormal neuromuscular synapse morphology 0.253611819866061 0.558314124616683 0.810390748794714 0.333333333333333 10.1 10 1 polyphagia 0.293718819366353 0.562452319610319 0.810390748794714 0.333333333333333 10.1 10 1 abnormal aorta morphology 0.358991609158336 0.626080052594906 0.810390748794714 0.333333333333333 10.1 10 1 abnormal skeleton physiology 0.358991609158336 0.626080052594906 0.810390748794714 0.333333333333333 10.1 10 1 abnormal single cell response 0.384305957285757 0.666174960800223 0.810390748794714 0.333333333333333 10.1 10 1 ocular hypertelorism 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal vasodilation 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 apnea 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal impulse conducting system conduction 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal retinal ganglion layer morphology 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 decreased fatty acid level 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 increased body temperature 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal associative learning 0.415085492002581 0.708422066110751 0.810390748794714 0.333333333333333 10.1 10 1 increased keratinocyte proliferation 0.415085492002581 0.708422066110751 0.810390748794714 0.333333333333333 10.1 10 1 abnormal iron level 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 decreased heart rate variability 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 long tibia 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 abnormal sperm axoneme morphology 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 atrioventricular block 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 abnormal eye physiology 0.279179454776259 0.558314124616683 0.810390748794714 0.333333333333333 10.1 10 1 delayed eyelid opening 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 abnormal pain threshold 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 enhanced paired-pulse facilitation 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 abnormal microglial cell physiology 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 abnormal fontanelle morphology 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 interdigital webbing 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 placental labyrinth hypoplasia 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 joint inflammation 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 arthritis 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 increased alcohol consumption 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 abnormal branching involved in lung morphogenesis 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 abnormal suckling behavior 0.248636590619996 0.558314124616683 0.801181763012956 0.329545454545455 10.1 10 1 dehydration 0.28607671970944 0.558314124616683 0.798813738097646 0.328571428571429 10.1 10 1 abnormal lens morphology 0.205565826869475 0.498629931094898 0.797728393344796 0.328125 10.1 10 1 increased percent body fat/body weight 0.334379702943666 0.58534096486444 0.794806311317892 0.326923076923077 10.1 10 1 decreased urine osmolality 0.343956139127108 0.601258535543698 0.793852162084617 0.326530612244898 10.1 10 1 perinatal lethality 0.376428098160961 0.652746527832269 0.790130980074846 0.325 10.1 10 1 abnormal nervous system development 0.402177237412239 0.69208984992248 0.78655572677134 0.323529411764706 10.1 10 1 decreased osteoblast cell number 0.402177237412239 0.69208984992248 0.78655572677134 0.323529411764706 10.1 10 1 abnormal eyelid morphology 0.416721898244487 0.710483702455903 0.78424911173682 0.32258064516129 10.1 10 1 abnormal body temperature homeostasis 0.416721898244487 0.710483702455903 0.78424911173682 0.32258064516129 10.1 10 1 decreased thymus weight 0.416721898244487 0.710483702455903 0.78424911173682 0.32258064516129 10.1 10 1 syndactyly 0.347967104856672 0.607842818350401 0.782919875954215 0.322033898305085 10.1 10 1 abnormal circulating cholesterol level 0.432683547316611 0.721864737726406 0.781448222052045 0.321428571428571 10.1 10 1 abnormal retinal inner nuclear layer morphology 0.432683547316611 0.721864737726406 0.781448222052045 0.321428571428571 10.1 10 1 abnormal heart left ventricle morphology 0.341487173923998 0.597152439462879 0.776624467594934 0.319444444444444 10.1 10 1 abnormal tibia morphology 0.390458820156169 0.674022425495122 0.775906036080045 0.319148936170213 10.1 10 1 abnormal innervation 0.390458820156169 0.674022425495122 0.775906036080045 0.319148936170213 10.1 10 1 abnormal photoreceptor outer segment morphology 0.402782446991588 0.692503143783477 0.773554805667681 0.318181818181818 10.1 10 1 increased body size 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 decreased airway responsiveness 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 abnormal retinal outer plexiform layer morphology 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 abnormal temporal bone morphology 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 abnormal sperm midpiece morphology 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 decreased total retina thickness 0.430167459776474 0.718148695432201 0.767738604121308 0.315789473684211 10.1 10 1 decreased threshold for auditory brainstem response 0.430167459776474 0.718148695432201 0.767738604121308 0.315789473684211 10.1 10 1 abnormal ear morphology 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 abnormal neurotransmitter level 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 decreased germ cell number 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 abnormal neural crest cell migration 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 increased susceptibility to ischemic brain injury 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 eyelids fail to open 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 abnormal hair shaft morphology 0.427148206010272 0.713587080221996 0.759741326995044 0.3125 10.1 10 1 abnormal long term potentiation 0.462270714654483 0.737521500066449 0.759741326995044 0.3125 10.1 10 1 abnormal hair follicle orientation 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 disorganized retinal layers 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal intestinal absorption 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 intraventricular hemorrhage 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 paternal imprinting 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 decreased cochlear coiling 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal pancreatic alpha cell morphology 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal fertilization 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal cartilage development 0.440884364655928 0.73406951611889 0.756364698875066 0.311111111111111 10.1 10 1 abnormal spinal nerve morphology 0.480674641850051 0.737521500066449 0.754501731636458 0.310344827586207 10.1 10 1 abnormal iris morphology 0.471414603291774 0.737521500066449 0.748052998887428 0.307692307692308 10.1 10 1 abnormal ureter morphology 0.501116581453901 0.741759890726914 0.748052998887428 0.307692307692308 10.1 10 1 abnormal Schwann cell morphology 0.501116581453901 0.741759890726914 0.748052998887428 0.307692307692308 10.1 10 1 increased liver weight 0.41458416781302 0.708052260511423 0.745927848322407 0.306818181818182 10.1 10 1 renal hypoplasia 0.48853297462426 0.737521500066449 0.742858186395154 0.305555555555556 10.1 10 1 abnormal food intake 0.451593097333018 0.734988077155669 0.739921988029956 0.304347826086957 10.1 10 1 abnormal carpal bone morphology 0.524119039876352 0.766683982177258 0.739921988029956 0.304347826086957 10.1 10 1 hypotension 0.524119039876352 0.766683982177258 0.739921988029956 0.304347826086957 10.1 10 1 abnormal ulna morphology 0.524119039876352 0.766683982177258 0.739921988029956 0.304347826086957 10.1 10 1 decreased food intake 0.446381460223808 0.734988077155669 0.738583973585055 0.30379746835443 10.1 10 1 absent vibrissae 0.507174673565851 0.750280702048798 0.736718862540649 0.303030303030303 10.1 10 1 decreased systemic arterial blood pressure 0.507174673565851 0.750280702048798 0.736718862540649 0.303030303030303 10.1 10 1 abnormal axon guidance 0.494892308714071 0.737521500066449 0.735005562860322 0.302325581395349 10.1 10 1 waved hair 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 increased urine glucose level 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 abnormal fibula morphology 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 abnormal optic stalk morphology 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 abnormal response to tactile stimuli 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 cataract 0.475705177354795 0.737521500066449 0.723323974130819 0.297520661157025 10.1 10 1 abnormal humerus morphology 0.530724682600825 0.776118546719314 0.722780938114204 0.297297297297297 10.1 10 1 abnormal brain commissure morphology 0.550300002156277 0.801785856087825 0.720347332261968 0.296296296296296 10.1 10 1 abnormal gametogenesis 0.533519024920273 0.779975653534634 0.718300890977133 0.295454545454545 10.1 10 1 decreased pancreatic beta cell number 0.550923605296522 0.801785856087825 0.715050660701218 0.294117647058824 10.1 10 1 abnormal urinary bladder morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 abnormal vagus nerve morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 abnormal cranial suture morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 decreased growth hormone level 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 abnormal ductus venosus valve morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 retinal degeneration 0.536693414012979 0.784385938517794 0.709091905195374 0.291666666666667 10.1 10 1 abnormal cardiovascular system morphology 0.553080537401323 0.801785856087825 0.709091905195374 0.291666666666667 10.1 10 1 abnormal inner cell mass apoptosis 0.575700551952119 0.821839381911562 0.709091905195374 0.291666666666667 10.1 10 1 abnormal lung saccule morphology 0.575700551952119 0.821839381911562 0.709091905195374 0.291666666666667 10.1 10 1 abnormal retinal outer nuclear layer morphology 0.571692440047783 0.816586244397852 0.703760387111199 0.289473684210526 10.1 10 1 abnormal eye development 0.587750644204575 0.837599385539318 0.69462064182404 0.285714285714286 10.1 10 1 abnormal mitotic spindle morphology 0.597346584092143 0.844981306755307 0.69462064182404 0.285714285714286 10.1 10 1 abnormal bile salt homeostasis 0.604575916768012 0.854964521296435 0.69462064182404 0.285714285714286 10.1 10 1 abnormal lens fiber morphology 0.611087304487643 0.863927064457523 0.685715248980142 0.282051282051282 10.1 10 1 abnormal crypts of Lieberkuhn morphology 0.616338843367186 0.865832294423688 0.68376719429554 0.28125 10.1 10 1 abnormal energy expenditure 0.624431640253394 0.865832294423688 0.68072822898756 0.28 10.1 10 1 impaired conditioned place preference behavior 0.624431640253394 0.865832294423688 0.68072822898756 0.28 10.1 10 1 abnormal stomach glandular epithelium morphology 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 delayed kidney development 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 abnormal epidermis stratum granulosum morphology 0.633292780224123 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 blepharoptosis 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 abnormal anterior eye segment morphology 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 abnormal glycogen homeostasis 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 stomach inflammation 0.641793038279607 0.865832294423688 0.670668205899073 0.275862068965517 10.1 10 1 abnormal pancreatic beta cell physiology 0.671280964529047 0.889617154643583 0.657073580103822 0.27027027027027 10.1 10 1 abnormal bone remodeling 0.695562055671306 0.919591078119784 0.643545594631096 0.264705882352941 10.1 10 1 abnormal optic vesicle formation 0.689747170227503 0.912145712887248 0.63978217010109 0.263157894736842 10.1 10 1 abnormal photoreceptor inner segment morphology 0.689747170227503 0.912145712887248 0.63978217010109 0.263157894736842 10.1 10 1 right-sided stomach 0.689747170227503 0.912145712887248 0.63978217010109 0.263157894736842 10.1 10 1 decreased neuronal precursor cell number 0.721670001588418 0.950129615952511 0.627399289389456 0.258064516129032 10.1 10 1 abnormal intestine physiology 0.721670001588418 0.950129615952511 0.627399289389456 0.258064516129032 10.1 10 1 increased susceptibility to weight loss 0.770283951433688 0.979091123756412 0.607793061596035 0.25 10.1 10 1 abnormal optic nerve morphology 0.823329397158735 1 0.578850534853367 0.238095238095238 10.1 10 1 abnormal heart looping 0.844202145134127 1 0.561039749165571 0.230769230769231 10.1 10 1 abnormal stomach morphology 0.813425618704464 1 0.561039749165571 0.230769230769231 10.1 10 1 abnormal phalanx morphology 0.867724616246154 1 0.557143639796366 0.229166666666667 10.1 10 1 abnormal retinal layer morphology 0.813308132523211 1 0.552539146905487 0.227272727272727 10.1 10 1 abnormal cranial ganglia morphology 0.842114972762245 1 0.548974378215774 0.225806451612903 10.1 10 1 abnormal nose morphology 0.842114972762245 1 0.548974378215774 0.225806451612903 10.1 10 1 cryptorchism 0.842487015570167 1 0.540260499196476 0.222222222222222 10.1 10 1 abnormal adaptive thermogenesis 6.21078537267698e-05 0.000903469509621871 1.63385093167702 1 11.2 11 2 pancreas cysts 0.000163653784410178 0.00210926833533843 1.63385093167702 1 11.2 11 2 increased neuronal precursor cell number 0.000163653784410178 0.00210926833533843 1.63385093167702 1 11.2 11 2 abnormal extraembryonic tissue physiology 0.000431205853950869 0.00480997561301698 1.63385093167702 1 11.2 11 2 abnormal kidney epithelium morphology 0.000431205853950869 0.00480997561301698 1.63385093167702 1 11.2 11 2 decreased white adipose tissue mass 0.000431205853950869 0.00480997561301698 1.63385093167702 1 11.2 11 2 broad head 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 abnormal brain ventricular system morphology 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased mortality induced by ionizing radiation 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased cardiomyocyte apoptosis 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 abnormal renal filtration rate 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased DN2 thymocyte number 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 ductus venosus stenosis 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased liver function 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 decreased prostate gland weight 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 myocardium hypoplasia 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 decreased capillary density 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 increased cardiac cell glucose uptake 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 absent neurocranium 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 abnormal tooth eruption 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased sensitivity to skin irradiation 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 vascular inflammation 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased urine microalbumin level 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 absent vas deferens 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 absent uterus 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 abnormal response to vitamins 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased heart right ventricle weight 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased unsaturated fatty acid level 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 abnormal hemoglobin content 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased placenta apoptosis 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased DN3 thymocyte number 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 hemolysis 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 leptocytosis 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased thyroid carcinoma incidence 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 aorta hypoplasia 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 pale lung 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased pre-pro B cell number 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 delayed optic fissure closure 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 cystinuria 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 impaired somite development 5.0367765394477e-06 9.86533987549303e-05 1.5317352484472 0.9375 11.2 11 2 testis degeneration 3.07725017499129e-05 0.000495447236912028 1.51714729370009 0.928571428571429 11.2 11 2 absent ovary 0.000184448807625487 0.00231725459074948 1.4976966873706 0.916666666666667 11.2 11 2 hematuria 0.000184448807625487 0.00231725459074948 1.4976966873706 0.916666666666667 11.2 11 2 embryonic lethality before implantation, incomplete penetrance 3.6206787019202e-07 9.84310193554809e-06 1.48531902879729 0.909090909090909 11.2 11 2 abnormal eye distance/ position 0.000447493733842988 0.00493632223030791 1.48531902879729 0.909090909090909 11.2 11 2 common atrioventricular valve 0.000447493733842988 0.00493632223030791 1.48531902879729 0.909090909090909 11.2 11 2 ketoaciduria 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 absent seminal vesicle 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 thin ventricle myocardium compact layer 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 decreased circulating lactate level 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 increased fatty acid oxidation 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 embryonic lethality between implantation and somite formation, incomplete penetrance 4.95673300614985e-06 9.7856137720617e-05 1.46186662307944 0.894736842105263 11.2 11 2 decreased circulating bicarbonate level 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 liver hyperplasia 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 positive geotaxis 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 enhanced conditioned place preference behavior 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 decreased transitional stage T1 B cell number 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 iris coloboma 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 abnormal pulmonary alveolar system morphology 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 increased cardiac muscle glycogen level 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 aminoaciduria 2.76173408504998e-05 0.000454954538845155 1.44163317500913 0.882352941176471 11.2 11 2 failure of vascular branching 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 clubfoot 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 increased sensitivity to skin irradiation 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 short ureter 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal neuron apoptosis 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 elevated level of mitotic sister chromatid exchange 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 binucleate 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal somite size 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 craniofacial phenotype 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 stomach epithelial hyperplasia 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal mitotic spindle assembly checkpoint 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal sphingomyelin level 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal cerebellum deep nucleus morphology 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 pleural effusion 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal anterior commissure pars posterior morphology 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 increased circulating ferritin level 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal heart echocardiography feature 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 increased brain apoptosis 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 decreased hepatocyte number 0.000149702454471459 0.00197551647478915 1.41600414078675 0.866666666666667 11.2 11 2 vagina atresia 0.000149702454471459 0.00197551647478915 1.41600414078675 0.866666666666667 11.2 11 2 decreased brown adipose tissue mass 0.000149702454471459 0.00197551647478915 1.41600414078675 0.866666666666667 11.2 11 2 increased hemangioma incidence 0.000344178990465149 0.00392727173753237 1.40044365572316 0.857142857142857 11.2 11 2 multiple persisting craniopharyngeal ducts 0.000344178990465149 0.00392727173753237 1.40044365572316 0.857142857142857 11.2 11 2 abnormal vitelline vein topology 0.000344178990465149 0.00392727173753237 1.40044365572316 0.857142857142857 11.2 11 2 asymmetric rib joints 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal lacrimal gland morphology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal gastrulation movements 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 detached tectorial membrane 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal renal/urinary system physiology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 decreased tidal volume 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 uremia 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal spinal cord central canal morphology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal sperm annulus morphology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 decreased skeletal muscle glycogen level 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 coronary fistula 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 increased compact bone volume 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 embryonic lethality at implantation, incomplete penetrance 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 small tail bud 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal Mullerian duct morphology 1.36634851988437e-06 3.22091437677887e-05 1.38248924988055 0.846153846153846 11.2 11 2 absent common myeloid progenitor cells 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 increased foot pad pigmentation 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 abnormal tail bud morphology 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 abnormal coping response 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 pale kidney 2.01082092174048e-07 5.71647662037651e-06 1.37032658785814 0.838709677419355 11.2 11 2 decreased cellular sensitivity to gamma-irradiation 0.000107024582049109 0.00144686765134325 1.36154244306418 0.833333333333333 11.2 11 2 delayed somite formation 0.0017627183649305 0.0149906390863747 1.36154244306418 0.833333333333333 11.2 11 2 decreased red blood cell distribution width 0.0017627183649305 0.0149906390863747 1.36154244306418 0.833333333333333 11.2 11 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0017627183649305 0.0149906390863747 1.36154244306418 0.833333333333333 11.2 11 2 thin tail 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal lens induction 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal lacrimal gland physiology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal lymph node cortex morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 chromatolysis 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal hippocampal fimbria morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 loss of hippocampal neurons 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 pancreas fibrosis 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 enlarged pancreas 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal milk ejection 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 shortened QT interval 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal cholesterol level 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal blastocoele morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 increased triiodothyronine level 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 delayed chorioallantoic fusion 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 absent sperm mitochondrial sheath 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal neural crest cell morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 increased erythrocyte clearance 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 enlarged lymphatic vessel 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 kidney microaneurysm 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal intestinal enteroendocrine cell morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 absent alveolar lamellar bodies 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 ectopic ureteric bud 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal kidney collecting duct epithelium morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 increased bone trabecular spacing 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 decreased hippocampus volume 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal cell nucleus morphology 3.01375657021125e-10 1.51448878149505e-08 1.35574864543412 0.829787234042553 11.2 11 2 decreased triglyceride level 6.57075191341509e-08 2.08213317001529e-06 1.35376220053239 0.828571428571429 11.2 11 2 decreased bone mineralization 6.57075191341509e-08 2.08213317001529e-06 1.35376220053239 0.828571428571429 11.2 11 2 increased triglyceride level 2.16387636883221e-06 4.76340041369038e-05 1.34209183673469 0.821428571428571 11.2 11 2 abnormal amino acid level 3.15199129402776e-09 1.32891158371085e-07 1.33678712591756 0.818181818181818 11.2 11 2 abnormal thrombopoiesis 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 delayed hepatic development 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal proximal-distal axis patterning 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 loss of cortex neurons 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal radial glial cell morphology 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 palatal shelf hypoplasia 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal palatal shelf elevation 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal heart valve morphology 4.7136036169812e-06 9.38007119779259e-05 1.33128594432942 0.814814814814815 11.2 11 2 decreased bone ossification 4.7136036169812e-06 9.38007119779259e-05 1.33128594432942 0.814814814814815 11.2 11 2 kidney failure 6.8297674879721e-09 2.59374757653902e-07 1.3298786653185 0.813953488372093 11.2 11 2 increased fibroblast apoptosis 6.82449243192124e-07 1.75009535303135e-05 1.32750388198758 0.8125 11.2 11 2 disorganized yolk sac vascular plexus 0.000518708332728972 0.00547892559517332 1.32750388198758 0.8125 11.2 11 2 decreased creatinine clearance 0.000518708332728972 0.00547892559517332 1.32750388198758 0.8125 11.2 11 2 kidney degeneration 0.000518708332728972 0.00547892559517332 1.32750388198758 0.8125 11.2 11 2 liver degeneration 7.17949378539483e-05 0.00103530381398085 1.32264123040521 0.80952380952381 11.2 11 2 increased muscle cell glucose uptake 7.17949378539483e-05 0.00103530381398085 1.32264123040521 0.80952380952381 11.2 11 2 abnormal erythropoiesis 1.3755395285465e-18 2.85137881438284e-16 1.30708074534161 0.8 11.2 11 2 abnormal pericardium morphology 0.000154470209993989 0.00202234024926341 1.30708074534161 0.8 11.2 11 2 increased skin tumor incidence 0.000154470209993989 0.00202234024926341 1.30708074534161 0.8 11.2 11 2 increased cranium width 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 jaundice 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 decreased incidence of induced tumors 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal neuron specification 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 acrania 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal pillar cell morphology 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal spinal cord dorsal column morphology 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 decreased transitional stage T2 B cell number 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal cerebellar granule cell migration 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 acanthocytosis 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 fusion of atlas and odontoid process 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 ruffled hair 2.18498058962436e-05 0.00037226980936237 1.30708074534161 0.8 11.2 11 2 delayed intramembranous bone ossification 0.0011220851344399 0.0103363201791581 1.30708074534161 0.8 11.2 11 2 abnormal placenta size 0.0011220851344399 0.0103363201791581 1.30708074534161 0.8 11.2 11 2 immune system phenotype 0.0011220851344399 0.0103363201791581 1.30708074534161 0.8 11.2 11 2 kidney cysts 2.40341744452803e-13 1.95833853857816e-11 1.30266493201276 0.797297297297297 11.2 11 2 abnormal brown adipose tissue morphology 9.72244827837375e-07 2.39451387054007e-05 1.29746985750822 0.794117647058823 11.2 11 2 increased circulating bilirubin level 9.90149330463201e-10 4.56110455468002e-08 1.29474979491386 0.792452830188679 11.2 11 2 kyphoscoliosis 0.000328773975350286 0.00378622807261035 1.28988231448186 0.789473684210526 11.2 11 2 abnormal digestive system development 0.000328773975350286 0.00378622807261035 1.28988231448186 0.789473684210526 11.2 11 2 decreased liver regeneration 0.000328773975350286 0.00378622807261035 1.28988231448186 0.789473684210526 11.2 11 2 increased respiratory quotient 1.39049848749844e-08 5.16248505619755e-07 1.2862230738734 0.787234042553192 11.2 11 2 abnormal blood flow velocity 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 megacephaly 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 irregularly shaped pupil 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 amyloid beta deposits 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 failure of zygotic cell division 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 lysosomal protein accumulation 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 abnormal renal tubule epithelial cell primary cilium morphology 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 failure to gastrulate 2.9015179400084e-08 1.00243414941263e-06 1.27866594652984 0.782608695652174 11.2 11 2 abnormal sacral vertebrae morphology 9.77362896330416e-05 0.0013465439836022 1.27866594652984 0.782608695652174 11.2 11 2 abnormal Wolffian duct morphology 9.77362896330416e-05 0.0013465439836022 1.27866594652984 0.782608695652174 11.2 11 2 increased embryonic tissue cell apoptosis 4.65579971729801e-13 3.61915681149338e-11 1.27775521579869 0.782051282051282 11.2 11 2 increased fatty acid level 4.28376132787051e-06 8.6632978073804e-05 1.27644604037267 0.78125 11.2 11 2 abnormal cell differentiation 1.9458186219367e-07 5.56347565754889e-06 1.27520072716255 0.780487804878049 11.2 11 2 abnormal liver physiology 3.41726449481651e-16 5.15178510960974e-14 1.27440372670807 0.78 11.2 11 2 abnormal apoptosis 2.81273216552345e-09 1.19601218149395e-07 1.2707729468599 0.777777777777778 11.2 11 2 increased brain weight 2.93580588580725e-05 0.000480448496114837 1.2707729468599 0.777777777777778 11.2 11 2 abnormal trophoblast giant cell morphology 1.3111185075934e-06 3.1511181523078e-05 1.2707729468599 0.777777777777778 11.2 11 2 delayed kidney development 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal thymus cortex morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal bile duct morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal redox activity 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 long tibia 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal anterior eye segment morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal glycogen homeostasis 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 decreased lactate dehydrogenase level 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 small thoracic cage 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal aerobic respiration 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal metanephric mesenchyme morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 distorted hair follicle pattern 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 renal tubular acidosis 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 synostosis 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal geniculate ganglion morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 biliary cyst 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 premature neuronal precursor differentiation 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 decreased fear-related response 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 short frontal bone 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal posterior eye segment morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal inguinal fat pad morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 decreased susceptibility to atherosclerosis 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 eye opacity 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal oxidative phosphorylation 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal lung lobe morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal infrahyoid muscle connection 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 renal interstitial fibrosis 1.24179884078183e-07 3.67735073386286e-06 1.2625211744777 0.772727272727273 11.2 11 2 abnormal lysosome physiology 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 abnormal vascular branching morphogenesis 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 prolonged PR interval 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 abnormal blood-brain barrier function 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 abnormal placenta morphology 1.28428531756694e-12 9.25988326796452e-11 1.26158109914301 0.772151898734177 11.2 11 2 abnormal circulating amino acid level 1.80400925904756e-09 7.87275970505403e-08 1.26121826304893 0.771929824561403 11.2 11 2 decreased glycogen level 2.7069725296092e-06 5.80482255810594e-05 1.26039929015084 0.771428571428571 11.2 11 2 vertebral transformation 3.83826833633066e-08 1.29900578049286e-06 1.25942675983437 0.770833333333333 11.2 11 2 increased hepatocyte apoptosis 8.28470540404598e-07 2.09220352208775e-05 1.25680840898232 0.769230769230769 11.2 11 2 increased thymocyte apoptosis 6.07153281300142e-05 0.000885839279482417 1.25680840898232 0.769230769230769 11.2 11 2 tight skin 0.00502704446629208 0.034591350234859 1.25680840898232 0.769230769230769 11.2 11 2 orthokeratosis 0.00502704446629208 0.034591350234859 1.25680840898232 0.769230769230769 11.2 11 2 abnormal embryonic-extraembryonic boundary morphology 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 increased brain size 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 enhanced behavioral response to cocaine 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 increased circulating magnesium level 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 abnormal cell cytoskeleton morphology 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 decreased hair follicle number 1.69174254701067e-06 3.79117980692707e-05 1.24688623733246 0.763157894736842 11.2 11 2 impaired branching involved in ureteric bud morphogenesis 1.69174254701067e-06 3.79117980692707e-05 1.24688623733246 0.763157894736842 11.2 11 2 abnormal erythrocyte physiology 0.000419031080842119 0.00470582308620664 1.24483880508725 0.761904761904762 11.2 11 2 embryonic lethality between implantation and placentation, complete penetrance 1.59440984448864e-07 4.63870700370234e-06 1.24314744801512 0.760869565217391 11.2 11 2 spontaneous skin ulceration 0.000124291477477193 0.00166671186104861 1.24172670807453 0.76 11.2 11 2 increased mortality induced by gamma-irradiation 3.72729245209662e-05 0.000581294042294066 1.23947312058257 0.758620689655172 11.2 11 2 blood in lymph vessels 3.72729245209662e-05 0.000581294042294066 1.23947312058257 0.758620689655172 11.2 11 2 decreased brown adipose tissue amount 1.12692595949191e-05 0.000204615206148623 1.23776585733107 0.757575757575758 11.2 11 2 atrioventricular septal defect 3.0637712304679e-08 1.05119047390192e-06 1.23309504277511 0.754716981132076 11.2 11 2 decreased mean corpuscular hemoglobin 5.69033714590109e-10 2.77543404910372e-08 1.22538819875776 0.75 11.2 11 2 abnormal urine homeostasis 1.65596645080555e-13 1.42041949875132e-11 1.22538819875776 0.75 11.2 11 2 abnormal retinal blood vessel morphology 6.89453459565656e-06 0.000130917212264853 1.22538819875776 0.75 11.2 11 2 failure of primitive streak formation 2.26994821793647e-05 0.000382813301160473 1.22538819875776 0.75 11.2 11 2 abnormal spongiotrophoblast layer morphology 2.26994821793647e-05 0.000382813301160473 1.22538819875776 0.75 11.2 11 2 pancreatic islet hyperplasia 2.26994821793647e-05 0.000382813301160473 1.22538819875776 0.75 11.2 11 2 premature aging 7.5244424851707e-05 0.00108191044403827 1.22538819875776 0.75 11.2 11 2 dilated vasculature 0.000851685271419176 0.00816403511620501 1.22538819875776 0.75 11.2 11 2 abnormal neuron proliferation 0.000851685271419176 0.00816403511620501 1.22538819875776 0.75 11.2 11 2 absent ductus venosus valve 0.000851685271419176 0.00816403511620501 1.22538819875776 0.75 11.2 11 2 abnormal bone marrow cell number 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 intraventricular hemorrhage 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 increased thymus weight 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 blepharitis 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 dystonia 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 decreased circulating triiodothyronine level 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 decreased liver cholesterol level 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 impaired embryo implantation 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal thymus involution 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal embryonic growth/weight/body size 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal respiratory function 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal corticospinal tract morphology 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 increased urine phosphate level 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 dilated bile duct 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal rostral-caudal body axis extension 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 increased hepatocyte proliferation 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 pale placenta 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal fatty acid level 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 hemoperitoneum 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 increased skeletal muscle glycogen level 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal pulmonary valve cusp morphology 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 prenatal growth retardation 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal colon goblet cell morphology 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal urination 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal secondary sex determination 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 coarse hair 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 early eyelid opening 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 colon polyps 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 liver failure 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 liver cysts 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased left ventricle systolic pressure 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal forelimb zeugopod morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal skin development 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 tau protein deposits 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 absent interparietal bone 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 Sertoli cell hypoplasia 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal epidermal lamellar body morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal brain ependyma morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 heart right ventricle hypoplasia 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 anomalous pulmonary venous connection 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased heart right ventricle size 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 lung situs inversus 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal bronchiole epithelium morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal maxillary prominence morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal foramen magnum morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 absent ureteric bud 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased aorta wall thickness 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 impaired neuron differentiation 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased cornea thickness 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased circulating lactate level 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased testis apoptosis 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 embryo cyst 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased mammary gland apoptosis 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 decreased basal metabolism 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 absent mesoderm 5.88647756405021e-09 2.27017254892634e-07 1.22538819875776 0.75 11.2 11 2 abnormal hepatocyte morphology 3.18424981073694e-15 3.77181971628959e-13 1.22170835431705 0.747747747747748 11.2 11 2 abnormal blood homeostasis 1.98112153286167e-15 2.52719990409918e-13 1.21822218589953 0.745614035087719 11.2 11 2 abnormal head morphology 3.77667308483725e-08 1.28691428747023e-06 1.21796160361378 0.745454545454545 11.2 11 2 pale liver 2.17644289519592e-10 1.15189397910635e-08 1.21434866543562 0.743243243243243 11.2 11 2 abnormal postnatal growth/weight/body size 4.52976643271461e-05 0.000693402707777082 1.21221198156682 0.741935483870968 11.2 11 2 abnormal nose morphology 4.52976643271461e-05 0.000693402707777082 1.21221198156682 0.741935483870968 11.2 11 2 abnormal mitochondrial ATP synthesis coupled electron transport 4.52976643271461e-05 0.000693402707777082 1.21221198156682 0.741935483870968 11.2 11 2 abnormal enzyme/coenzyme level 2.31642259741726e-08 8.29079310946106e-07 1.21130327693296 0.741379310344828 11.2 11 2 decreased circulating alkaline phosphatase level 2.4143729510446e-07 6.74803675923982e-06 1.20904968944099 0.74 11.2 11 2 dilated heart 0.000503350297059939 0.0053507857433188 1.20762894950041 0.739130434782609 11.2 11 2 abnormal hepatocyte physiology 0.000503350297059939 0.0053507857433188 1.20762894950041 0.739130434782609 11.2 11 2 abnormal hematopoietic stem cell physiology 0.000503350297059939 0.0053507857433188 1.20762894950041 0.739130434782609 11.2 11 2 decreased embryo size 6.45555784309016e-58 1.07054667564578e-54 1.20658865874893 0.738493723849372 11.2 11 2 abnormal pancreas morphology 2.54238481041043e-06 5.49928888338777e-05 1.20593759242828 0.738095238095238 11.2 11 2 increased hepatocellular carcinoma incidence 4.55673823847494e-08 1.50130945274257e-06 1.20389016018307 0.736842105263158 11.2 11 2 persistence of hyaloid vascular system 8.29252235762182e-06 0.000154514227450069 1.20389016018307 0.736842105263158 11.2 11 2 delayed sexual maturation 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 oliguria 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 abnormal blastocyst morphology 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 increased liver cholesterol level 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 enlarged kidney 1.46871712050733e-07 4.323590339955e-06 1.20226766670573 0.735849056603774 11.2 11 2 abnormal direction of heart looping 2.71674464980494e-05 0.000449030054245169 1.20136097917428 0.735294117647059 11.2 11 2 abnormal neural tube closure 5.04014133929333e-11 2.91566315848655e-09 1.20078201002769 0.734939759036145 11.2 11 2 abnormal ectoderm development 1.53596526470968e-06 3.52139501932289e-05 1.19815734989648 0.733333333333333 11.2 11 2 abnormal myocardial trabeculae morphology 1.53596526470968e-06 3.52139501932289e-05 1.19815734989648 0.733333333333333 11.2 11 2 macrocytosis 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 abnormal cricoid cartilage morphology 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 abnormal trophectoderm morphology 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 decreased thymocyte apoptosis 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 abnormal branching involved in lung morphogenesis 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 thick ventricular wall 4.98760610697444e-06 9.80764441984104e-05 1.19550068171489 0.731707317073171 11.2 11 2 decreased bone resorption 0.000296855311419533 0.00347495335132277 1.19396798853321 0.730769230769231 11.2 11 2 embryonic lethality between implantation and somite formation, complete penetrance 4.88488290525686e-29 2.20929931396844e-26 1.19371149702117 0.730612244897959 11.2 11 2 decreased susceptibility to hepatic steatosis 1.68266796522601e-08 6.11041834087548e-07 1.19297052154195 0.73015873015873 11.2 11 2 abnormal chromosome morphology 1.62520453668293e-05 0.000288764020357056 1.19226959879134 0.72972972972973 11.2 11 2 oligodactyly 9.25723368948328e-07 2.30273688025897e-05 1.19134963768116 0.729166666666667 11.2 11 2 small heart 9.25723368948328e-07 2.30273688025897e-05 1.19134963768116 0.729166666666667 11.2 11 2 single kidney 5.31800757378865e-05 0.000804166798771993 1.18825522303783 0.727272727272727 11.2 11 2 abnormal facial nerve morphology 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 abnormal germ layer development 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 aphakia 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 abnormal circulating lipid level 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 abnormal sphenoid bone morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 decreased atrioventricular cushion size 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal large intestine morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal food preference 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 impaired myelopoiesis 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 pharyngeal arch hypoplasia 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal dorsal-ventral polarity of the somites 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 increased glycogen level 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal palate development 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 increased number of Howell-Jolly bodies 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 aorta dilation 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal pulmonary alveolar sac morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal brain ependyma motile cilium morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 hypolactation 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal extraembryonic tissue morphology 1.33714373341156e-12 9.50327153388932e-11 1.18534283278529 0.725490196078431 11.2 11 2 abnormal gastrulation 5.56886237491779e-07 1.4429734539175e-05 1.18534283278529 0.725490196078431 11.2 11 2 abnormal gluconeogenesis 5.56886237491779e-07 1.4429734539175e-05 1.18534283278529 0.725490196078431 11.2 11 2 polychromatophilia 0.000174919613219901 0.00220869308570814 1.18313343328336 0.724137931034483 11.2 11 2 narrow eye opening 3.15644680804475e-05 0.000506558802258794 1.18000345065562 0.722222222222222 11.2 11 2 abnormal mitral valve morphology 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 cortical renal glomerulopathies 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 right pulmonary isomerism 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 abnormal body wall morphology 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 increased adipocyte glucose uptake 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 abnormal placenta labyrinth morphology 7.07764859018452e-10 3.34317655360234e-08 1.17885446969101 0.721518987341772 11.2 11 2 abnormal double-strand DNA break repair 5.78817395547172e-06 0.000111613044296402 1.17789253213925 0.720930232558139 11.2 11 2 delayed bone ossification 2.24747124288293e-09 9.72275602899354e-08 1.17637267080745 0.72 11.2 11 2 abnormal thyroid gland morphology 0.00057909954829133 0.00607810179904929 1.17637267080745 0.72 11.2 11 2 abnormal preimplantation embryo development 0.00057909954829133 0.00607810179904929 1.17637267080745 0.72 11.2 11 2 decreased cell proliferation 6.65768479776917e-21 1.57723723185246e-18 1.17460634547591 0.718918918918919 11.2 11 2 scoliosis 0.000103048574260365 0.00139691187178561 1.17433035714286 0.71875 11.2 11 2 small liver 1.35461853454299e-09 5.96391788438176e-08 1.17302118171683 0.717948717948718 11.2 11 2 abnormal iris morphology 1.87219903358673e-05 0.000324536243626968 1.17302118171683 0.717948717948718 11.2 11 2 abnormal allantois morphology 3.44913785612679e-06 7.20985749337428e-05 1.17211045098569 0.717391304347826 11.2 11 2 abnormal mesoderm development 6.41766793666891e-07 1.65429523237968e-05 1.17144029063635 0.716981132075472 11.2 11 2 decreased hemoglobin content 4.72225172837283e-16 6.90976539666318e-14 1.17034712127219 0.716312056737589 11.2 11 2 small kidney 1.55432816543018e-10 8.31482002474749e-09 1.16968873517787 0.715909090909091 11.2 11 2 lethality throughout fetal growth and development, complete penetrance 4.6576069188021e-21 1.21955760110739e-18 1.16949329846355 0.715789473684211 11.2 11 2 lethality throughout fetal growth and development, incomplete penetrance 7.58613143789471e-20 1.71550017743301e-17 1.16834033103161 0.715083798882682 11.2 11 2 abnormal embryonic tissue morphology 1.72687574723762e-16 2.86373561416905e-14 1.1670363797693 0.714285714285714 11.2 11 2 absent kidney 2.05407618730918e-06 4.54179068082808e-05 1.1670363797693 0.714285714285714 11.2 11 2 abnormal reproductive system morphology 1.11006593483845e-05 0.000202292235378069 1.1670363797693 0.714285714285714 11.2 11 2 ovary cysts 6.07178280007044e-05 0.000885839279482417 1.1670363797693 0.714285714285714 11.2 11 2 abnormal embryonic epiblast morphology 6.07178280007044e-05 0.000885839279482417 1.1670363797693 0.714285714285714 11.2 11 2 abnormal mitotic spindle morphology 0.0003379652790452 0.00388308836778261 1.1670363797693 0.714285714285714 11.2 11 2 abnormal eye pigmentation 0.00193332074786182 0.0162196808104765 1.1670363797693 0.714285714285714 11.2 11 2 trunk curl 0.00193332074786182 0.0162196808104765 1.1670363797693 0.714285714285714 11.2 11 2 absent segment of posterior cerebral artery 0.00193332074786182 0.0162196808104765 1.1670363797693 0.714285714285714 11.2 11 2 abnormal fluid regulation 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 increased lactate dehydrogenase level 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 abnormal ventral body wall morphology 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 absent olfactory bulb 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 vascular smooth muscle hypoplasia 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 split sternum 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 abnormal glucose tolerance 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 decreased tongue size 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 increased stomach tumor incidence 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 failure of atrioventricular cushion closure 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 cellular necrosis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 mammary gland hyperplasia 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal oculomotor nerve morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 skin photosensitivity 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 absent epidermis stratum corneum 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 excessive tearing 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 limp posture 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal circulating alanine transaminase level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal axial mesoderm 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal tumor incidence 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased cholesterol efflux 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 calcinosis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 aorta coarctation 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal locus ceruleus morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 renal necrosis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal organ of Corti supporting cell morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 absent vestibular saccule 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal vestibular saccular macula morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 urolithiasis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 absent fibula 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal thyroid hormone level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 retinal pigment epithelium atrophy 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased brain cholesterol level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal retina inner limiting membrane morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 heart block 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal aortic valve cusp morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 thick pulmonary valve 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 thick mitral valve cusps 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 increased circulating lactate dehydrogenase level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 impaired mammary gland growth during pregnancy 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased CD8-positive, naive alpha-beta T cell number 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased areal bone mineral density 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased femur compact bone thickness 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 fragmented Meckel's cartilage 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 embryo tumor 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 short limbs 2.95150615929066e-10 1.49834113698684e-08 1.16435353751696 0.71264367816092 11.2 11 2 eyelids open at birth 1.22276260741998e-06 2.96743608386068e-05 1.16254777830865 0.711538461538462 11.2 11 2 decreased birth body size 7.4922879868647e-13 5.56330339323163e-11 1.16089408303367 0.710526315789474 11.2 11 2 microcephaly 2.57985024927687e-08 9.00082790323741e-07 1.16027095148078 0.710144927536232 11.2 11 2 decreased heart rate 2.03792739395184e-11 1.23642546157444e-09 1.16003416149068 0.71 11.2 11 2 small cranium 0.000197525972801759 0.00246907466002199 1.15950711280305 0.709677419354839 11.2 11 2 increased oxygen consumption 5.57972713717817e-10 2.7484299512338e-08 1.15889426549184 0.709302325581395 11.2 11 2 increased circulating creatinine level 5.57972713717817e-10 2.7484299512338e-08 1.15889426549184 0.709302325581395 11.2 11 2 abnormal primitive streak formation 0.001114652227893 0.0103363201791581 1.15731107660455 0.708333333333333 11.2 11 2 increased body temperature 0.001114652227893 0.0103363201791581 1.15731107660455 0.708333333333333 11.2 11 2 abnormal embryo size 1.41166794842172e-12 9.89161696253248e-11 1.15670862419612 0.707964601769911 11.2 11 2 abnormal lipid homeostasis 3.13784869538687e-14 3.18587699174483e-12 1.15626373626374 0.707692307692308 11.2 11 2 palatal shelves fail to meet at midline 2.11053076849603e-05 0.000360820981899235 1.15565065899106 0.707317073170732 11.2 11 2 decreased erythrocyte cell number 8.12819078974578e-17 1.4442053278209e-14 1.15514301538948 0.707006369426752 11.2 11 2 abnormal embryonic neuroepithelium morphology 4.32988380559218e-07 1.14580701770325e-05 1.15496358963375 0.706896551724138 11.2 11 2 preweaning lethality, complete penetrance 3.00313172243988e-74 1.49405803191384e-70 1.15473518549606 0.706756756756757 11.2 11 2 increased bone mineral content 4.41610762706266e-12 2.89080729534694e-10 1.15418827283606 0.706422018348624 11.2 11 2 abnormal lung development 1.05002349088604e-09 4.79253841023674e-08 1.15330654000731 0.705882352941177 11.2 11 2 small lung 2.31297704086907e-06 5.04695648172089e-05 1.15330654000731 0.705882352941177 11.2 11 2 increased kidney weight 2.31297704086907e-06 5.04695648172089e-05 1.15330654000731 0.705882352941177 11.2 11 2 hyperlipidemia 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 nephrocalcinosis 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 increased hepatoma incidence 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 increased trabecular bone mass 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 prenatal lethality, complete penetrance 2.57732117050575e-28 9.86320986405084e-26 1.15192367844855 0.705035971223022 11.2 11 2 polydactyly 7.19730312256647e-11 4.06892989031457e-09 1.15036443148688 0.704081632653061 11.2 11 2 abnormal maxilla morphology 1.37150545193953e-06 3.22091437677887e-05 1.14974695192087 0.703703703703704 11.2 11 2 abnormal neuronal precursor proliferation 1.37150545193953e-06 3.22091437677887e-05 1.14974695192087 0.703703703703704 11.2 11 2 abnormal osteoblast physiology 1.37150545193953e-06 3.22091437677887e-05 1.14974695192087 0.703703703703704 11.2 11 2 abnormal atrioventricular cushion morphology 0.000644906301672542 0.00668418510587687 1.14974695192087 0.703703703703704 11.2 11 2 abnormal type II pneumocyte morphology 0.000644906301672542 0.00668418510587687 1.14974695192087 0.703703703703704 11.2 11 2 increased neuron apoptosis 3.29256323789606e-09 1.37651278222966e-07 1.14974695192086 0.703703703703704 11.2 11 2 embryonic lethality during organogenesis, complete penetrance 1.16823739272407e-54 1.45299525720056e-51 1.14661324312334 0.701785714285714 11.2 11 2 enlarged liver 8.03674413149585e-11 4.49244966901032e-09 1.14369565217391 0.7 11.2 11 2 abnormal kidney development 4.82502992424769e-07 1.26339599332275e-05 1.14369565217391 0.7 11.2 11 2 abnormal brain vasculature morphology 0.000374248424787936 0.00423155889390905 1.14369565217391 0.7 11.2 11 2 increased urine glucose level 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 increased mammary adenocarcinoma incidence 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal trachea morphology 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 decreased myocardial infarction size 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal lens epithelium morphology 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal physiological neovascularization 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 kidney atrophy 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 increased urine calcium level 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal sperm mitochondrial sheath morphology 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal prostate gland epithelium morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 fused cornea and lens 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal mammary gland physiology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal primordial germ cell migration 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 aneurysm 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal hypaxial muscle morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 bifid ureter 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 increased atrioventricular cushion size 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal hindlimb zeugopod morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 increased heart rate variability 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal gas homeostasis 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal plasma membrane morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal placental transport 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 osteosclerosis 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 vascular smooth muscle hyperplasia 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 crystalluria 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 increased circulating fructosamine level 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal left subclavian artery morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal inferior vena cava valve morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 thick aortic valve 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal circadian temperature homeostasis 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 lethality during fetal growth through weaning, complete penetrance 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 pale yolk sac 3.66610509112424e-09 1.49498957609369e-07 1.14172715707551 0.698795180722892 11.2 11 2 abnormal liver morphology 4.78051930361231e-18 9.5132334141885e-16 1.14095735452306 0.698324022346369 11.2 11 2 abnormal organ of Corti morphology 2.33602410243368e-05 0.000392625672621878 1.13989599884443 0.697674418604651 11.2 11 2 enlarged pericardium 0.000217746120862067 0.00267478259577477 1.13874458874459 0.696969696969697 11.2 11 2 abnormal somite development 1.14268106128384e-08 4.2743144961557e-07 1.13749115496501 0.69620253164557 11.2 11 2 increased lymphocyte cell number 1.00850145067783e-07 3.09709550439644e-06 1.13659195247097 0.695652173913043 11.2 11 2 abnormal cell death 1.37389712233229e-05 0.000245868279985724 1.13659195247097 0.695652173913043 11.2 11 2 abnormal forelimb morphology 1.37389712233229e-05 0.000245868279985724 1.13659195247097 0.695652173913043 11.2 11 2 abnormal pulmonary artery morphology 0.00211433807358136 0.0176787091026341 1.13659195247097 0.695652173913043 11.2 11 2 hydrops fetalis 5.98779491852586e-08 1.92188901417201e-06 1.13461870255349 0.694444444444444 11.2 11 2 cataract 2.18576538088698e-12 1.48961407807024e-10 1.13424362199066 0.694214876033058 11.2 11 2 increased circulating LDL cholesterol level 8.08829554864768e-06 0.000151846303224612 1.13369248320446 0.693877551020408 11.2 11 2 increased urine protein level 2.1121974695056e-08 7.61462493535535e-07 1.13112756808409 0.692307692307692 11.2 11 2 increased insulin sensitivity 3.22356752690209e-14 3.20744968926758e-12 1.13112756808409 0.692307692307692 11.2 11 2 liver hypoplasia 4.76595951612951e-06 9.44647354292602e-05 1.13112756808409 0.692307692307692 11.2 11 2 heart inflammation 0.00121414908125287 0.0109625983289165 1.13112756808409 0.692307692307692 11.2 11 2 decreased circulating glycerol level 0.00121414908125287 0.0109625983289165 1.13112756808409 0.692307692307692 11.2 11 2 absent myocardial trabeculae 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 absent trabeculae carneae 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 pup cannibalization 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 abnormal grip strength 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 increased pituitary adenoma incidence 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 anal atresia 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 abnormal vertebral arch development 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 increased circulating ammonia level 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 increased circulating thyroxine level 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 absent hypoglossal nerve 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 double outlet right ventricle 5.84672317639802e-11 3.34338480489427e-09 1.12995298078598 0.691588785046729 11.2 11 2 disheveled coat 4.34233693588603e-05 0.000672994587415359 1.12813516711032 0.69047619047619 11.2 11 2 perinatal lethality, incomplete penetrance 2.37958222883652e-21 6.57690088247872e-19 1.12779090859122 0.690265486725664 11.2 11 2 embryonic lethality, complete penetrance 2.00256617345568e-29 9.96276671294201e-27 1.12679374598415 0.689655172413793 11.2 11 2 abnormal spinal nerve morphology 0.000700288980879196 0.00708117414608536 1.12679374598415 0.689655172413793 11.2 11 2 oxidative stress 2.63465048802146e-09 1.12994708430231e-07 1.12554175293306 0.688888888888889 11.2 11 2 abnormal autopod morphology 2.54547302957395e-05 0.000423536064285298 1.12554175293306 0.688888888888889 11.2 11 2 small placenta 2.54547302957395e-05 0.000423536064285298 1.12554175293306 0.688888888888889 11.2 11 2 extramedullary hematopoiesis 1.0728355018273e-10 5.86522705669321e-09 1.12519922653229 0.688679245283019 11.2 11 2 embryonic lethality before implantation, complete penetrance 2.62496631664975e-12 1.741227656711e-10 1.12408944099379 0.688 11.2 11 2 overriding aortic valve 1.49419282784137e-05 0.000266437609982467 1.12327251552795 0.6875 11.2 11 2 kidney cortex cysts 0.00040537624959283 0.00456277566000979 1.12327251552795 0.6875 11.2 11 2 abnormal tympanic ring morphology 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 vasculature congestion 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 abnormal hair follicle orientation 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 delayed hair appearance 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 poor circulation 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 increased heart left ventricle size 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 decreased fibroblast apoptosis 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 decreased white adipose tissue amount 3.42328789757907e-07 9.35761389585487e-06 1.12174840085288 0.686567164179104 11.2 11 2 embryonic lethality between somite formation and embryo turning, complete penetrance 2.0253367875962e-07 5.72502870357449e-06 1.12035492457853 0.685714285714286 11.2 11 2 abnormal liver development 0.000235375966814131 0.00287008685024584 1.12035492457853 0.685714285714286 11.2 11 2 increased red blood cell distribution width 0.000235375966814131 0.00287008685024584 1.12035492457853 0.685714285714286 11.2 11 2 embryonic growth arrest 5.1822784421517e-21 1.28909176248523e-18 1.12015107542922 0.685589519650655 11.2 11 2 decreased rib number 4.81805291436403e-09 1.93304945556138e-07 1.11983041384605 0.685393258426966 11.2 11 2 increased circulating alkaline phosphatase level 2.91409783805586e-15 3.5714371840449e-13 1.11949045318611 0.685185185185185 11.2 11 2 abnormal cell adhesion 5.16678419537255e-06 0.000100802946556778 1.11949045318611 0.685185185185185 11.2 11 2 decreased hematocrit 7.02999850781476e-14 6.35895319570517e-12 1.1190759806007 0.684931506849315 11.2 11 2 decreased percent body fat/body weight 1.19886310373037e-07 3.61475390367187e-06 1.1190759806007 0.684931506849315 11.2 11 2 abnormal cell morphology 4.13102482034277e-11 2.41786452720062e-09 1.11789800588428 0.684210526315789 11.2 11 2 decreased neuron apoptosis 0.000137022357358371 0.00182757701838578 1.11789800588428 0.684210526315789 11.2 11 2 abnormal triglyceride level 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 decreased germ cell number 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 increased liver adenoma incidence 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 increased circulating VLDL cholesterol level 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 decreased susceptibility to weight gain 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 abnormal developmental patterning 2.49310671091587e-08 8.83832669956379e-07 1.11580063626723 0.682926829268293 11.2 11 2 Leydig cell hyperplasia 7.99446232542691e-05 0.00112989914968747 1.11580063626723 0.682926829268293 11.2 11 2 liver fibrosis 7.99446232542691e-05 0.00112989914968747 1.11580063626723 0.682926829268293 11.2 11 2 increased bone trabecula number 7.99446232542691e-05 0.00112989914968747 1.11580063626723 0.682926829268293 11.2 11 2 abnormal astrocyte morphology 4.67335270965119e-05 0.000713188028543394 1.11398927159797 0.681818181818182 11.2 11 2 abnormal enterocyte morphology 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 abnormal tail movements 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 intestinal inflammation 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 intracerebral hemorrhage 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 abnormal forebrain development 2.18197880829612e-07 6.13296303461761e-06 1.11192632850242 0.680555555555556 11.2 11 2 abnormal cornea morphology 7.63794667678523e-08 2.37492404481291e-06 1.11018076126772 0.67948717948718 11.2 11 2 failure of blastocyst to hatch from the zona pellucida 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 abnormal hormone level 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 hypoxia 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 subcutaneous edema 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 decreased circulating cholesterol level 2.75458195449504e-16 4.28251413237901e-14 1.10709024878661 0.677595628415301 11.2 11 2 decreased circulating glucose level 5.0272195875281e-24 1.78645838913945e-21 1.10680224403927 0.67741935483871 11.2 11 2 hypoglycemia 5.58083998941044e-09 2.17701176510777e-07 1.10680224403927 0.67741935483871 11.2 11 2 lethargy 5.58083998941044e-09 2.17701176510777e-07 1.10680224403927 0.67741935483871 11.2 11 2 prenatal lethality 1.92105793521811e-06 4.26663536951344e-05 1.10680224403927 0.67741935483871 11.2 11 2 abnormal eyelid morphology 0.000745365573958903 0.00746115438721437 1.10680224403927 0.67741935483871 11.2 11 2 decreased thymus weight 0.000745365573958903 0.00746115438721437 1.10680224403927 0.67741935483871 11.2 11 2 abnormal brain morphology 1.86232694128533e-14 1.93022427768636e-12 1.10614752517264 0.677018633540373 11.2 11 2 decreased liver weight 3.94703362862051e-07 1.05625983667231e-05 1.10457527775348 0.676056338028169 11.2 11 2 malocclusion 0.000250346291185979 0.00302299222973361 1.1039533322142 0.675675675675676 11.2 11 2 increased erythroid progenitor cell number 0.000250346291185979 0.00302299222973361 1.1039533322142 0.675675675675676 11.2 11 2 atrial septal defect 4.9667299045401e-05 0.000755641629207554 1.10107345395625 0.673913043478261 11.2 11 2 decreased circulating creatinine level 2.90775457835564e-05 0.000477428350736611 1.10034858663962 0.673469387755102 11.2 11 2 microphthalmia 1.69103874365138e-13 1.42591826265519e-11 1.09991271871067 0.673202614379085 11.2 11 2 distended pericardium 1.70491935759304e-05 0.000299716388834819 1.09970735785953 0.673076923076923 11.2 11 2 abnormal placenta vasculature 1.70491935759304e-05 0.000299716388834819 1.09970735785953 0.673076923076923 11.2 11 2 kinked neural tube 1.70491935759304e-05 0.000299716388834819 1.09970735785953 0.673076923076923 11.2 11 2 abnormal neural tube morphology 3.56633825786344e-14 3.47892800644522e-12 1.0993194540296 0.672839506172839 11.2 11 2 abnormal embryo turning 1.00100133183462e-05 0.000184885842035488 1.09913608130999 0.672727272727273 11.2 11 2 glomerulosclerosis 5.88419820992536e-06 0.000113026587236983 1.09862390233455 0.672413793103448 11.2 11 2 decreased circulating HDL cholesterol level 1.92774528175295e-11 1.18401639218777e-09 1.0977435947205 0.671875 11.2 11 2 abnormal axial skeleton morphology 2.47514646223432e-07 6.87924784894734e-06 1.09639996730958 0.671052631578947 11.2 11 2 abnormal renal glomerulus morphology 7.82209015729898e-10 3.63690640491238e-08 1.09423044048094 0.669724770642202 11.2 11 2 abnormal cell cycle 2.7579272401297e-10 1.41450391955106e-08 1.09396975425331 0.669565217391304 11.2 11 2 pallor 8.46689153520159e-15 9.36061897502842e-13 1.09234605146406 0.668571428571429 11.2 11 2 increased rib number 2.60943380356936e-07 7.17233876947931e-06 1.08923395445135 0.666666666666667 11.2 11 2 increased circulating alanine transaminase level 2.60943380356936e-07 7.17233876947931e-06 1.08923395445135 0.666666666666667 11.2 11 2 perimembraneous ventricular septal defect 1.26700211242055e-06 3.05987160645255e-05 1.08923395445135 0.666666666666667 11.2 11 2 gliosis 3.64673290952627e-06 7.59100260455781e-05 1.08923395445135 0.666666666666667 11.2 11 2 increased cell proliferation 1.79385196668082e-05 0.000312042431267031 1.08923395445135 0.666666666666667 11.2 11 2 distended abdomen 3.05819674566657e-05 0.000493978208106856 1.08923395445135 0.666666666666667 11.2 11 2 abnormal trophoblast layer morphology 3.05819674566657e-05 0.000493978208106856 1.08923395445135 0.666666666666667 11.2 11 2 abnormal kidney physiology 5.22129571236976e-05 0.000791949578324377 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lysosome morphology 0.000452176972076181 0.00496596122754746 1.08923395445135 0.666666666666667 11.2 11 2 belly spot 0.000780636507054358 0.00770260308151599 1.08923395445135 0.666666666666667 11.2 11 2 increased cardiomyocyte apoptosis 0.000780636507054358 0.00770260308151599 1.08923395445135 0.666666666666667 11.2 11 2 abnormal trigeminal ganglion morphology 0.00235263464041354 0.0190935682480544 1.08923395445135 0.666666666666667 11.2 11 2 thin epidermis 0.00235263464041354 0.0190935682480544 1.08923395445135 0.666666666666667 11.2 11 2 abnormal eye muscle morphology 0.00235263464041354 0.0190935682480544 1.08923395445135 0.666666666666667 11.2 11 2 abnormal body weight 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 blindness 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 abnormal impulse conducting system conduction 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 decreased fatty acid level 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 abnormal heart shape 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal phrenic nerve morphology 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 absent allantois 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 absent ureter 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal eye anterior chamber morphology 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal pregnancy 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal hypoglossal nerve topology 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal mineral level 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 amyloidosis 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 mesocardia 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal glossopharyngeal nerve morphology 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal mating frequency 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 myocarditis 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 decreased circulating ketone body level 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal vascular endothelial cell development 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 increased osteosarcoma incidence 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal nucleotide metabolism 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal amacrine cell morphology 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 decreased renal glomerular filtration rate 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal thymus corticomedullary boundary morphology 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 reduced cerebellar foliation 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 increased type II pneumocyte number 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 heart hyperplasia 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal head movements 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 thick tail 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 dilated uterus 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lens vesicle development 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal ion homeostasis 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lung volume 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 increased pheochromocytoma incidence 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal germ cell morphology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal thymus physiology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 absent adrenal gland 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal liver vasculature morphology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal cerebellar layer morphology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 prolonged RR interval 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 fusion of atlas and occipital bones 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 symmetric azygos veins 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 decreased fatty acid oxidation 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 albuminuria 8.92911206980569e-05 0.00124432304054015 1.08923395445135 0.666666666666667 11.2 11 2 abnormal scapula morphology 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 left pulmonary isomerism 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 abnormal embryonic/fetal subventricular zone morphology 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 complete atrioventricular septal defect 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 vascular ring 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 abnormal apical ectodermal ridge morphology 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 absent egg cylinders 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lymph node B cell domain morphology 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 abnormal energy homeostasis 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 abnormal coronary vessel morphology 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 heterochrony 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 prenatal lethality, incomplete penetrance 5.77241644941463e-24 1.91451812238919e-21 1.08565094802223 0.664473684210526 11.2 11 2 abnormal bone structure 1.24343791621015e-15 1.67191990085013e-13 1.08359025520548 0.663212435233161 11.2 11 2 short tail 1.61739117032773e-07 4.67820992580258e-06 1.08267230412333 0.662650602409639 11.2 11 2 abnormal enzyme/coenzyme activity 6.27425479963611e-13 4.72945721639237e-11 1.08229615856312 0.662420382165605 11.2 11 2 abnormal angiogenesis 7.8286047267109e-07 1.98710757731565e-05 1.08187426556992 0.662162162162162 11.2 11 2 ventricular septal defect 2.37873865387329e-11 1.42581021723128e-09 1.08122488125685 0.661764705882353 11.2 11 2 pericardial effusion 6.47240975233957e-06 0.000123372561371224 1.08044980965738 0.661290322580645 11.2 11 2 abnormal interventricular septum morphology 5.43693964108776e-05 0.000817183526115154 1.07834161490683 0.66 11.2 11 2 testicular atrophy 5.43693964108776e-05 0.000817183526115154 1.07834161490683 0.66 11.2 11 2 increased cellular sensitivity to gamma-irradiation 9.28768321105264e-05 0.00128708144777122 1.07764635919123 0.659574468085106 11.2 11 2 abnormal glucose homeostasis 1.81868641551419e-14 1.92509891854959e-12 1.07726435055628 0.659340659340659 11.2 11 2 small spleen 5.91463608112949e-08 1.92188901417201e-06 1.07726435055628 0.659340659340659 11.2 11 2 increased grip strength 5.91463608112949e-08 1.92188901417201e-06 1.07726435055628 0.659340659340659 11.2 11 2 abnormal nervous system morphology 4.81677977215467e-07 1.26339599332275e-05 1.07544618287601 0.658227848101266 11.2 11 2 decreased total retina thickness 0.000468276933162149 0.00513144877198611 1.07490192873488 0.657894736842105 11.2 11 2 decreased bone marrow cell number 1.37900454724402e-06 3.22091437677887e-05 1.07431294137667 0.657534246575342 11.2 11 2 seminiferous tubule degeneration 1.37900454724402e-06 3.22091437677887e-05 1.07431294137667 0.657534246575342 11.2 11 2 abnormal midbrain development 0.000806828814859991 0.0078635771882911 1.07367346938775 0.657142857142857 11.2 11 2 decreased circulating thyroxine level 0.000806828814859991 0.0078635771882911 1.07367346938775 0.657142857142857 11.2 11 2 polydipsia 0.00139443610229414 0.0123220596961161 1.07221467391304 0.65625 11.2 11 2 bradykinesia 0.00139443610229414 0.0123220596961161 1.07221467391304 0.65625 11.2 11 2 hemorrhage 9.03037532109487e-18 1.72792758547873e-15 1.07069380203515 0.65531914893617 11.2 11 2 preweaning lethality, incomplete penetrance 7.78678246160818e-30 4.30436030516675e-27 1.07059180853164 0.655256723716381 11.2 11 2 lordosis 0.00241884036082061 0.0192539692721321 1.07045405868494 0.655172413793103 11.2 11 2 decreased trophoblast giant cell number 0.00241884036082061 0.0192539692721321 1.07045405868494 0.655172413793103 11.2 11 2 decreased bone strength 0.00241884036082061 0.0192539692721321 1.07045405868494 0.655172413793103 11.2 11 2 increased blood urea nitrogen level 1.59962559769038e-11 9.94767168563703e-10 1.07045405868494 0.655172413793103 11.2 11 2 increased circulating calcium level 3.29609527481045e-05 0.00052390012754575 1.06942970073405 0.654545454545455 11.2 11 2 abnormal contextual conditioning behavior 3.29609527481045e-05 0.00052390012754575 1.06942970073405 0.654545454545455 11.2 11 2 azoospermia 2.08489976198085e-12 1.44060782164649e-10 1.06868237040509 0.654088050314465 11.2 11 2 decreased body temperature 5.61438736758321e-05 0.00084131256487128 1.06828714763497 0.653846153846154 11.2 11 2 abnormal ureter morphology 0.00421441212132347 0.0296062900972343 1.06828714763497 0.653846153846154 11.2 11 2 thick skin 0.00421441212132347 0.0296062900972343 1.06828714763497 0.653846153846154 11.2 11 2 abnormal digit morphology 2.41298640190348e-06 5.242186615489e-05 1.06654158040028 0.652777777777778 11.2 11 2 perinatal lethality, complete penetrance 5.86689962907726e-16 8.10772934851649e-14 1.06622196949815 0.652582159624413 11.2 11 2 decreased spleen weight 4.08558857750865e-06 8.39909222029155e-05 1.06555495544153 0.652173913043478 11.2 11 2 abnormal nasal cavity morphology 0.00738295056556441 0.0467900370237999 1.06555495544153 0.652173913043478 11.2 11 2 anophthalmia 1.80618663567888e-07 5.19409162572395e-06 1.06475678693559 0.651685393258427 11.2 11 2 abnormal left-right axis patterning 0.000279928723299216 0.00333168755601339 1.0639029322548 0.651162790697674 11.2 11 2 delayed endochondral bone ossification 0.000279928723299216 0.00333168755601339 1.0639029322548 0.651162790697674 11.2 11 2 decreased oxygen consumption 0.000279928723299216 0.00333168755601339 1.0639029322548 0.651162790697674 11.2 11 2 abnormal retinal pigment epithelium morphology 8.68414932190763e-07 2.18200216547932e-05 1.06200310559006 0.65 11.2 11 2 decreased circulating phosphate level 0.000479958613383457 0.00521352423926354 1.06200310559006 0.65 11.2 11 2 small gonad 0.0130226045947034 0.0710388792309752 1.06200310559006 0.65 11.2 11 2 absent placental labyrinth 0.0130226045947034 0.0710388792309752 1.06200310559006 0.65 11.2 11 2 abnormal postnatal subventricular zone morphology 0.0130226045947034 0.0710388792309752 1.06200310559006 0.65 11.2 11 2 decreased bone mineral content 2.94329496574555e-15 3.5714371840449e-13 1.06043209507883 0.649038461538462 11.2 11 2 increased circulating phosphate level 0.000824787459873478 0.00799866981066384 1.05979519892563 0.648648648648649 11.2 11 2 abnormal respiratory electron transport chain 0.000824787459873478 0.00799866981066384 1.05979519892563 0.648648648648649 11.2 11 2 short snout 1.40969952328511e-08 5.1950037987729e-07 1.05897745571659 0.648148148148148 11.2 11 2 abnormal chondrocyte morphology 5.75500267484353e-05 0.000857219709800795 1.05897745571659 0.648148148148148 11.2 11 2 abnormal small intestine morphology 5.75500267484353e-05 0.000857219709800795 1.05897745571659 0.648148148148148 11.2 11 2 abnormal ovary morphology 4.19331667258729e-06 8.58508248811596e-05 1.05855130784708 0.647887323943662 11.2 11 2 embryonic lethality during organogenesis, incomplete penetrance 1.4074166311244e-16 2.41444749649789e-14 1.05845125573859 0.647826086956522 11.2 11 2 enlarged liver sinusoidal spaces 0.00142108189777071 0.0124674399737622 1.05719766167337 0.647058823529412 11.2 11 2 abnormal adipose tissue morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal vagus nerve morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 increased incidence of corneal inflammation 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal dorsal-ventral axis patterning 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal testis development 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal ectoplacental cone morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal ductus venosus valve morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 impaired balance 3.98855426254993e-08 1.34074712541797e-06 1.05719766167336 0.647058823529412 11.2 11 2 failure of chorioallantoic fusion 9.79796828269341e-05 0.0013465439836022 1.05719766167336 0.647058823529412 11.2 11 2 osteopetrosis 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 abnormal capillary morphology 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 inner cell mass degeneration 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 abnormal podocyte morphology 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 preaxial polydactyly 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 trabecula carnea hypoplasia 0.000285153619789128 0.00336170440391211 1.05292615596963 0.644444444444444 11.2 11 2 abnormal metabolism 0.000285153619789128 0.00336170440391211 1.05292615596963 0.644444444444444 11.2 11 2 abnormal fertility/fecundity 4.28210744686484e-06 8.6632978073804e-05 1.05193142176466 0.643835616438356 11.2 11 2 abnormal vitelline vasculature morphology 8.79007282996944e-09 3.31292517644681e-07 1.05134755603565 0.643478260869565 11.2 11 2 abnormal eye development 5.86061829798564e-05 0.000870345553208315 1.05033274179237 0.642857142857143 11.2 11 2 myoclonus 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 abnormal somite shape 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 abnormal brainstem morphology 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 abnormal renal tubule epithelium morphology 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 prolonged QRS complex duration 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 midline facial cleft 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal kidney blood vessel morphology 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal sagittal suture morphology 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 increased circulating growth hormone level 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal viscerocranium morphology 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 spina bifida occulta 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 sternebra fusion 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal renal reabsorbtion 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 pulmonary alveolar hemorrhage 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 decreased compact bone area 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 cleft palate 1.15471921611379e-09 5.22248009106011e-08 1.04766013939595 0.641221374045801 11.2 11 2 abnormal kidney morphology 2.5653713780119e-12 1.72469224400125e-10 1.04566459627329 0.64 11.2 11 2 increased circulating chloride level 0.000169348758339386 0.00214926038963889 1.04566459627329 0.64 11.2 11 2 abnormal circulating protein level 0.000169348758339386 0.00214926038963889 1.04566459627329 0.64 11.2 11 2 decreased oocyte number 0.000169348758339386 0.00214926038963889 1.04566459627329 0.64 11.2 11 2 abnormal keratinocyte physiology 0.00742216859680078 0.0468595035140659 1.04566459627329 0.64 11.2 11 2 abnormal cochlear outer hair cell morphology 0.00742216859680078 0.0468595035140659 1.04566459627329 0.64 11.2 11 2 abnormal embryo development 7.01440958610384e-10 3.34317655360234e-08 1.04518405188162 0.639705882352941 11.2 11 2 heart right ventricle hypertrophy 0.00143428976747749 0.0124674399737622 1.04384920634921 0.638888888888889 11.2 11 2 renal hypoplasia 0.00143428976747749 0.0124674399737622 1.04384920634921 0.638888888888889 11.2 11 2 decreased total body fat amount 8.44583371641993e-22 2.47164839642289e-19 1.04194685163834 0.637724550898204 11.2 11 2 thymus hypoplasia 7.12315004385625e-10 3.34317655360234e-08 1.04187595643172 0.63768115942029 11.2 11 2 polyuria 4.40520140567171e-06 8.87282469361003e-05 1.0397233201581 0.636363636363636 11.2 11 2 decreased circulating total protein level 0.000100580906249015 0.00137367734284307 1.0397233201581 0.636363636363636 11.2 11 2 omphalocele 0.000491674528416798 0.00527172581653787 1.0397233201581 0.636363636363636 11.2 11 2 lethality, incomplete penetrance 0.000491674528416798 0.00527172581653787 1.0397233201581 0.636363636363636 11.2 11 2 abnormal aorta morphology 0.00246858539396376 0.0193100822876882 1.0397233201581 0.636363636363636 11.2 11 2 abnormal QRS complex 0.00246858539396376 0.0193100822876882 1.0397233201581 0.636363636363636 11.2 11 2 testis hypoplasia 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 increased skin papilloma incidence 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 abnormal chorion morphology 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 increased myocardial infarction size 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 parakeratosis 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 cleft upper lip 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 abnormal mesenteric lymph node morphology 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 increased adenoma incidence 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 absent semicircular canals 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal stomach epithelium morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal enteric ganglia morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal hemoglobin 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 focal hepatic necrosis 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 vasculitis 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 secondary sex reversal 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal fear/anxiety-related behavior 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 fatigue 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 patent ductus arteriosus 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 impaired luteinization 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 dilated renal glomerular capsule 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 pathological neovascularization 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal coronal suture morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 increased circulating triiodothyronine level 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal aorta smooth muscle morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 decreased colon length 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 reduced sympathetic cervical ganglion size 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 increased circulating aspartate transaminase level 3.5354392192189e-05 0.000554852054120316 1.03736567090604 0.634920634920635 11.2 11 2 abnormal testis morphology 2.58717264354362e-08 9.00082790323741e-07 1.03714015662976 0.634782608695652 11.2 11 2 decreased grip strength 1.68038531696829e-14 1.81737325041679e-12 1.03701040868998 0.634703196347032 11.2 11 2 abnormal mammary gland development 0.000839555561514948 0.0080945521677071 1.03610059081957 0.634146341463415 11.2 11 2 increased circulating free fatty acid level 1.25011227019514e-05 0.000226156674335303 1.03553932289388 0.633802816901408 11.2 11 2 abnormal retina morphology 7.79349141721222e-14 6.9236821072555e-12 1.03477225672878 0.633333333333333 11.2 11 2 increased erythrocyte cell number 5.97570251594731e-05 0.000879559763811772 1.03477225672878 0.633333333333333 11.2 11 2 abnormal lactation 0.00426092536876779 0.0296062900972343 1.03477225672878 0.633333333333333 11.2 11 2 abnormal fat pad morphology 0.00426092536876779 0.0296062900972343 1.03477225672878 0.633333333333333 11.2 11 2 abnormal cellular respiration 0.00426092536876779 0.0296062900972343 1.03477225672878 0.633333333333333 11.2 11 2 abnormal eye morphology 1.21861682813488e-09 5.46181866664055e-08 1.0343804459538 0.633093525179856 11.2 11 2 abnormal vertebrae morphology 7.24990661601949e-08 2.26844562356585e-06 1.03427260812582 0.63302752293578 11.2 11 2 abnormal visceral yolk sac morphology 4.44104387287481e-06 8.90894889820653e-05 1.03408286815001 0.632911392405063 11.2 11 2 abnormal craniofacial development 0.00028976559084788 0.00339996182657595 1.03366079350995 0.63265306122449 11.2 11 2 incomplete embryo turning 0.00010105847386544 0.00137367734284307 1.03190585158549 0.631578947368421 11.2 11 2 decreased brain weight 0.00010105847386544 0.00137367734284307 1.03190585158549 0.631578947368421 11.2 11 2 abnormal facial morphology 0.00010105847386544 0.00137367734284307 1.03190585158549 0.631578947368421 11.2 11 2 incomplete somite formation 0.00143594836280718 0.0124674399737622 1.03190585158549 0.631578947368421 11.2 11 2 irregular coat pigmentation 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 shiny skin 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 increased malignant tumor incidence 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal neurotransmitter level 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal neural crest cell migration 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal optic vesicle formation 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal cochlear inner hair cell morphology 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 absent amnion 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 decreased eye pigmentation 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 eyelids fail to open 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 Leydig cell hypoplasia 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 decreased body length 2.36724554120878e-17 4.36186909907913e-15 1.03159201160629 0.631386861313869 11.2 11 2 abnormal spermatogenesis 4.59771636818393e-12 2.97060245866429e-10 1.03003645692682 0.630434782608696 11.2 11 2 astrocytosis 1.25582102380007e-05 0.000226366289616136 1.02954990215264 0.63013698630137 11.2 11 2 abnormal axon morphology 1.22023474705928e-07 3.64781378594157e-06 1.02872095698183 0.62962962962963 11.2 11 2 abnormal long bone epiphyseal plate proliferative zone 0.000171006035520398 0.00216477106034092 1.02872095698183 0.62962962962963 11.2 11 2 abnormal trigeminal nerve morphology 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 abnormal fetal cardiomyocyte proliferation 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 decreased circulating fructosamine level 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 thick interventricular septum 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 increased tumor incidence 1.58092010776087e-08 5.78314524713996e-07 1.02774494089361 0.629032258064516 11.2 11 2 abnormal dermal layer morphology 0.00246058711500423 0.0193082348535427 1.02699201419698 0.628571428571429 11.2 11 2 abnormal artery morphology 0.00246058711500423 0.0193082348535427 1.02699201419698 0.628571428571429 11.2 11 2 increased circulating serum albumin level 0.00246058711500423 0.0193082348535427 1.02699201419698 0.628571428571429 11.2 11 2 decreased body weight 1.01042056412151e-72 2.51342115325226e-69 1.02676577128007 0.62843295638126 11.2 11 2 absent gastric milk in neonates 7.48770934504413e-06 0.000141103613604525 1.02639353400223 0.628205128205128 11.2 11 2 abnormal vasculogenesis 0.000838098771007049 0.0080945521677071 1.02590639895999 0.627906976744186 11.2 11 2 abnormal homeostasis 0.000838098771007049 0.0080945521677071 1.02590639895999 0.627906976744186 11.2 11 2 decreased leukocyte cell number 3.43263686327248e-09 1.41135275989922e-07 1.02562905200163 0.627737226277372 11.2 11 2 abnormal blood vessel morphology 1.24030320204663e-09 5.5093825269482e-08 1.02538230884558 0.627586206896552 11.2 11 2 impaired hematopoiesis 0.000289549306570883 0.00339996182657595 1.02516136889538 0.627450980392157 11.2 11 2 impaired glucose tolerance 3.86888271025788e-15 4.47620732175185e-13 1.02115683229814 0.625 11.2 11 2 liver inflammation 4.40476211760176e-08 1.46091276900458e-06 1.02115683229814 0.625 11.2 11 2 abnormal coat/hair pigmentation 1.22449226583365e-07 3.64781378594157e-06 1.02115683229814 0.625 11.2 11 2 thymus atrophy 0.000490595776249265 0.00527172581653787 1.02115683229814 0.625 11.2 11 2 abnormal vertebral body morphology 0.00422531229150616 0.0296062900972343 1.02115683229814 0.625 11.2 11 2 abnormal embryonic hematopoiesis 0.00422531229150616 0.0296062900972343 1.02115683229814 0.625 11.2 11 2 ocular hypertelorism 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 hemolytic anemia 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 increased hemangiosarcoma incidence 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 hypopigmentation 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 abnormal inner cell mass apoptosis 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 abnormal lung saccule morphology 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 absent mandible 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal meiosis 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal olfaction 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 increased intestinal adenocarcinoma incidence 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 small pancreas 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 increased cochlear outer hair cell number 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal thoracic cage shape 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal pulmonary alveolus wall morphology 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal ear pigmentation 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal exoccipital bone morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal bone marrow development 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 enlarged pituitary gland 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal pupil morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent eyelids 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 spinning 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal erythrocyte cell number 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal thyroid physiology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 hypospadia 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent tympanic ring 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal cellular cholesterol metabolism 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 decreased susceptibility to age related obesity 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal perineum morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 increased cardiac output 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal platelet shape 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal lateral ganglionic eminence morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 long femur 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 small frontal bone 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal NK cell morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal choroid pigmentation 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 non-pigmented tail tip 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal vertebral body development 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 ocular hypertension 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent outer ear 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal corneocyte envelope morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 hypergranulosis 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 decreased hippocampus pyramidal cell number 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 increased caudal vertebrae number 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal lateral plate mesoderm morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 decreased quadriceps weight 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal hepatic vein morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 myocardial trabeculae hypoplasia 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 sinoatrial block 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal heart right ventricle pressure 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal stomach position or orientation 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal branching involved in ureteric bud morphogenesis 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 increased cardiac stroke volume 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 prolonged PQ interval 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent hypoglossal canal 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 retropleural edema 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal umbilical vein topology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 postnatal growth retardation 4.81961133196532e-35 2.99719579706593e-32 1.01982198676572 0.624183006535948 11.2 11 2 abnormal definitive hematopoiesis 1.59034582432639e-06 3.61277190686017e-05 1.01896079609965 0.623655913978495 11.2 11 2 thin ventricular wall 2.6562028431104e-06 5.72061001925291e-05 1.01661835748792 0.622222222222222 11.2 11 2 edema 9.77498222008533e-11 5.40339294943605e-09 1.01640726563628 0.622093023255814 11.2 11 2 small seminiferous tubules 2.09998127319341e-05 0.000360255408073697 1.01563706563707 0.621621621621622 11.2 11 2 skin inflammation 0.00243561498711267 0.0193082348535427 1.01563706563707 0.621621621621622 11.2 11 2 abnormal tail morphology 5.94486516778868e-05 0.000877617335600851 1.01496800301148 0.621212121212121 11.2 11 2 anemia 1.01411564541404e-12 7.41944902343361e-11 1.01438138412175 0.62085308056872 11.2 11 2 thrombocytopenia 3.42223713705478e-09 1.41135275989922e-07 1.01411437138574 0.620689655172414 11.2 11 2 dermatitis 0.000169334976794537 0.00214926038963889 1.01411437138574 0.620689655172414 11.2 11 2 abnormal outer ear morphology 0.00727325424236079 0.0463903075073653 1.01411437138574 0.620689655172414 11.2 11 2 abnormal hindlimb morphology 0.000486235159677529 0.00524733171235511 1.01298757763975 0.62 11.2 11 2 short stride length 0.000486235159677529 0.00524733171235511 1.01298757763975 0.62 11.2 11 2 kidney inflammation 0.000486235159677529 0.00524733171235511 1.01298757763975 0.62 11.2 11 2 atelectasis 3.5173485214309e-05 0.00055375977513034 1.01252733794069 0.619718309859155 11.2 11 2 corneal opacity 3.5173485214309e-05 0.00055375977513034 1.01252733794069 0.619718309859155 11.2 11 2 decreased body size 1.37532681931294e-43 9.77464418011695e-41 1.01143152913339 0.619047619047619 11.2 11 2 spina bifida 0.00141145100523404 0.0124502992039704 1.01143152913339 0.619047619047619 11.2 11 2 small ears 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 abnormal hematopoietic system physiology 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 embryonic lethality at implantation, complete penetrance 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 increased bone ossification 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 abnormal behavior 5.01474890327645e-16 7.12810736965723e-14 1.01087179945485 0.618705035971223 11.2 11 2 abnormal myocardial fiber morphology 1.57322596135808e-06 3.59027484300755e-05 1.01062944227444 0.618556701030928 11.2 11 2 abnormal rostral-caudal axis patterning 0.000285027673388353 0.00336170440391211 1.01001693958216 0.618181818181818 11.2 11 2 enlarged spleen 1.81112472984045e-16 2.90656307450201e-14 1.0098106452726 0.618055555555556 11.2 11 2 kinked tail 9.37740566094627e-07 2.32102453548297e-05 1.00914322250639 0.617647058823529 11.2 11 2 pericardial edema 5.8903455934297e-05 0.000872156825217642 1.00914322250639 0.617647058823529 11.2 11 2 premature death 4.19858161228019e-46 3.48132392018233e-43 1.00763628887398 0.616724738675958 11.2 11 2 abnormal incisor morphology 0.000167485325565189 0.00214752447084231 1.00754140786749 0.616666666666667 11.2 11 2 abnormal seminiferous tubule morphology 5.60115589816671e-09 2.17701176510777e-07 1.00716838254063 0.616438356164384 11.2 11 2 abnormal heart ventricle morphology 2.06131107867036e-05 0.000354845073231316 1.00544672718586 0.615384615384615 11.2 11 2 small lens 0.00239682330421945 0.0191707330200832 1.00544672718586 0.615384615384615 11.2 11 2 decreased trabecular bone volume 0.00239682330421945 0.0191707330200832 1.00544672718586 0.615384615384615 11.2 11 2 decreased kidney weight 0.000479801192814988 0.00521352423926354 1.00544672718586 0.615384615384615 11.2 11 2 abnormal nasal bone morphology 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 ventricular hypoplasia 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 abnormal kidney cortex morphology 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 abnormal erythrocyte osmotic lysis 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 uterus hypoplasia 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal telomere length 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 axonal dystrophy 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal retinal inner plexiform layer morphology 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal exocrine pancreas morphology 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 increased renin activity 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal aorta tunica media morphology 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal heart morphology 3.54141111396595e-13 2.7965905225366e-11 1.00435858137721 0.614718614718615 11.2 11 2 abnormal craniofacial bone morphology 0.000281075626430619 0.00333735379831105 1.00324180015256 0.614035087719298 11.2 11 2 increased circulating cholesterol level 2.58933400338398e-10 1.34186840279534e-08 1.00259034443817 0.613636363636364 11.2 11 2 hyperglycemia 7.24772894350391e-06 0.000137100576022555 1.00259034443817 0.613636363636364 11.2 11 2 osteoporosis 0.00138830197982686 0.0123115906410671 1.00259034443817 0.613636363636364 11.2 11 2 abnormal limb morphology 3.43734643724633e-05 0.0005446114180032 1.00209523809524 0.613333333333333 11.2 11 2 abnormal cranial ganglia morphology 0.0071187006366731 0.0457565060302954 1.00139250651172 0.612903225806452 11.2 11 2 abnormal respiratory system physiology 0.000807696068988292 0.0078635771882911 1.00031689694511 0.612244897959184 11.2 11 2 decreased urine osmolality 0.000807696068988292 0.0078635771882911 1.00031689694511 0.612244897959184 11.2 11 2 reduced female fertility 5.71585154352723e-13 4.37482483523815e-11 1.00002944956093 0.612068965517241 11.2 11 2 abnormal cranium morphology 4.19240860487522e-08 1.39981428250028e-06 0.999819226847131 0.611940298507463 11.2 11 2 abnormal craniofacial morphology 1.52150624707951e-06 3.52069468800956e-05 0.999345715491769 0.611650485436893 11.2 11 2 increased heart weight 2.5049327932432e-08 8.83832669956379e-07 0.999117476205371 0.611510791366906 11.2 11 2 diluted coat color 0.000471614183304904 0.00514535210952171 0.998464458247067 0.611111111111111 11.2 11 2 neurodegeneration 0.000471614183304904 0.00514535210952171 0.998464458247067 0.611111111111111 11.2 11 2 abnormal pharyngeal arch morphology 0.00407334008968911 0.029032760667913 0.998464458247067 0.611111111111111 11.2 11 2 abnormal megakaryocyte differentiation 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal radius morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal iron level 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal thyroid cartilage morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal thymus medulla morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal white adipose tissue morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal metacarpal bone morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 increased circulating renin level 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 absent inner cell mass 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 decreased pulmonary respiratory rate 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 increased gastrointestinal tumor incidence 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 atrioventricular block 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 primary atelectasis 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 decreased birth weight 4.24157783619635e-06 8.6482990717528e-05 0.997508989865969 0.610526315789474 11.2 11 2 short humerus 0.00234694827404188 0.0190935682480544 0.996250568095743 0.609756097560976 11.2 11 2 abnormal cholesterol homeostasis 0.00234694827404188 0.0190935682480544 0.996250568095743 0.609756097560976 11.2 11 2 decreased circulating LDL cholesterol level 0.000162184795868596 0.00210122229022464 0.995627911490683 0.609375 11.2 11 2 increased sacral vertebrae number 0.000162184795868596 0.00210122229022464 0.995627911490683 0.609375 11.2 11 2 abnormal myelin sheath morphology 0.0013596150579051 0.0120787230590677 0.994517958412098 0.608695652173913 11.2 11 2 abnormal blood vessel physiology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 abnormal ulna morphology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 abnormal chondrocyte physiology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 abnormal vertebral artery topology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 decreased litter size 5.56626536929708e-15 6.29367504823931e-13 0.994265157710926 0.608540925266904 11.2 11 2 abnormal heart development 5.19010994653644e-09 2.0656637587215e-07 0.992719553424011 0.607594936708861 11.2 11 2 postnatal lethality, incomplete penetrance 1.54570944137447e-28 6.40825372569833e-26 0.99239185110664 0.607394366197183 11.2 11 2 hydronephrosis 1.96536185647301e-05 0.000339502612359486 0.991980922803904 0.607142857142857 11.2 11 2 lymphoid hyperplasia 0.0122001146815992 0.0695252812611183 0.991980922803904 0.607142857142857 11.2 11 2 insulin resistance 1.10493061268986e-07 3.37241091909942e-06 0.99021268586486 0.606060606060606 11.2 11 2 decreased bone mineral density 6.63108753564055e-14 6.10919638700217e-12 0.98890977443609 0.605263157894737 11.2 11 2 increased exploration in new environment 3.25591659866278e-05 0.000520841963933998 0.988378958668814 0.604938271604938 11.2 11 2 hypoactivity 5.20210926590238e-19 1.12523885208106e-16 0.988111438786101 0.604774535809019 11.2 11 2 abnormal blood circulation 0.00228834265758119 0.0187245143445171 0.987909865665174 0.604651162790698 11.2 11 2 abnormal pancreatic islet morphology 0.000772208032756664 0.00768346992592881 0.986476034220087 0.60377358490566 11.2 11 2 thrombocytosis 0.000451115745442047 0.00496526733091633 0.985944527736132 0.603448275862069 11.2 11 2 decreased circulating alanine transaminase level 0.000155250426250057 0.00202722013279274 0.985116002922908 0.602941176470588 11.2 11 2 increased bone mineral density 1.38606965160927e-06 3.22228809194211e-05 0.983202330566702 0.601769911504425 11.2 11 2 small testis 6.00741967090344e-14 5.639040162782e-12 0.982678458907192 0.601449275362319 11.2 11 2 spleen hypoplasia 3.83282578587923e-06 7.94512845197882e-05 0.980310559006211 0.6 11.2 11 2 abnormal learning/memory/conditioning 0.000751493948179736 0.00749234948335508 0.980310559006211 0.6 11.2 11 2 abnormal platelet physiology 0.000751493948179736 0.00749234948335508 0.980310559006211 0.6 11.2 11 2 abnormal cell proliferation 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal vascular regression 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 waved hair 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal circulating enzyme level 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 spleen atrophy 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal heart right ventricle morphology 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 decreased circulating VLDL cholesterol level 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal induced retinal neovascularization 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal auchene hair morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 retarded hair growth 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 enlarged testis 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal epidermis suprabasal layer morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal gland morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal respiratory mechanics 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 decreased circulating parathyroid hormone level 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 rickets 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 absent CD4-positive, alpha beta T cells 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 absent pharyngeal arches 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal ear physiology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal reproductive system development 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal embryonic erythrocyte morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal deltoid tuberosity morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal respiratory conducting tube morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal gonadal fat pad morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 increased susceptibility to atherosclerosis 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 tachypnea 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 protruding tongue 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal hippocampus neuron morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal retinal blood vessel pattern 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 umbilical hernia 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 increased T-helper 17 cell number 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal vibrissa follicle morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 increased kidney iron level 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal heart and great artery attachment 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 thick aortic valve cusps 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 decreased trabecular bone connectivity density 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 domed cranium 0.000151335468514072 0.00199178295200399 0.980310559006211 0.6 11.2 11 2 epidermal hyperplasia 0.000439300292036751 0.00487839051982775 0.980310559006211 0.6 11.2 11 2 abnormal eating behavior 0.000439300292036751 0.00487839051982775 0.980310559006211 0.6 11.2 11 2 increased B cell derived lymphoma incidence 0.00128988743295444 0.0115271365633687 0.980310559006211 0.6 11.2 11 2 abnormal axon extension 0.00128988743295444 0.0115271365633687 0.980310559006211 0.6 11.2 11 2 irregular heartbeat 0.00222301502974418 0.0183104300877108 0.980310559006211 0.6 11.2 11 2 abnormal cell migration 0.00222301502974418 0.0183104300877108 0.980310559006211 0.6 11.2 11 2 thick pulmonary interalveolar septum 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 holoprosencephaly 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 abnormal hippocampus pyramidal cell morphology 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 decreased bone volume 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 increased metastatic potential 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 emphysema 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 disorganized myocardium 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 liver hemorrhage 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 abnormal optic cup morphology 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 abnormal egg cylinder morphology 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 decreased placenta weight 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 abnormal vertebrae development 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 abnormal energy expenditure 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 increased liver glycogen level 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 abnormal fontanelle morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 absent incisors 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal pup retrieval 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 placental labyrinth hypoplasia 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 altered righting response 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal glial cell morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal pericyte morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal ear development 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal olfactory nerve morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal dendritic cell morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal cerebral aqueduct morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 absent chorion 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal secondary palate development 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 ostium primum atrial septal defect 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 herniated liver 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 cyanosis 5.75223596192498e-10 2.77838581656085e-08 0.978608630952381 0.598958333333333 11.2 11 2 abnormal retinal pigmentation 3.02542740991018e-05 0.000493491848009939 0.976554579852931 0.597701149425287 11.2 11 2 decreased compact bone thickness 0.000250336892348854 0.00302299222973361 0.975433392045981 0.597014925373134 11.2 11 2 rib fusion 0.000250336892348854 0.00302299222973361 0.975433392045981 0.597014925373134 11.2 11 2 absent vitelline blood vessels 0.000729366822955613 0.00734534401660764 0.974577748719625 0.596491228070175 11.2 11 2 decreased cardiac muscle contractility 6.12759839671618e-06 0.00011724923855255 0.974026516961299 0.596153846153846 11.2 11 2 abnormal neuron morphology 1.03260945777556e-05 0.000188868825457111 0.973709141100445 0.595959595959596 11.2 11 2 increased mean corpuscular hemoglobin 1.03260945777556e-05 0.000188868825457111 0.973709141100445 0.595959595959596 11.2 11 2 pulmonary hypoplasia 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 hepatic necrosis 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 abnormal innervation 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 decreased bone trabecula number 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 increased or absent threshold for auditory brainstem response 8.08314162398662e-14 7.05502273321639e-12 0.972395710202239 0.595155709342561 11.2 11 2 abnormal myocardium layer morphology 8.4238281705314e-05 0.00118721091071937 0.972037896061011 0.594936708860759 11.2 11 2 abnormal intestine morphology 0.000142887531772118 0.00190070981434837 0.971478932348497 0.594594594594595 11.2 11 2 increased white adipose tissue amount 0.00647533690680123 0.0424997376138999 0.971478932348497 0.594594594594595 11.2 11 2 decreased width of hypertrophic chondrocyte zone 0.00647533690680123 0.0424997376138999 0.971478932348497 0.594594594594595 11.2 11 2 abnormal pulmonary alveolus morphology 1.00340054974033e-05 0.000184885842035488 0.970604513867536 0.594059405940594 11.2 11 2 abnormal lens morphology 7.24936785093714e-07 1.84951820812371e-05 0.97009899068323 0.59375 11.2 11 2 increased circulating follicle stimulating hormone level 0.0113474989873017 0.0657969783937368 0.97009899068323 0.59375 11.2 11 2 abnormal heart atrium morphology 0.0113474989873017 0.0657969783937368 0.97009899068323 0.59375 11.2 11 2 kyphosis 8.91527351539852e-08 2.7548748906278e-06 0.969418219461698 0.593333333333333 11.2 11 2 syndactyly 0.000706184710654057 0.00712630615720879 0.969233603537214 0.593220338983051 11.2 11 2 increased circulating triglyceride level 1.49356032890413e-07 4.37086037429297e-06 0.96904262154637 0.593103448275862 11.2 11 2 increased spleen weight 3.43737707841612e-06 7.20985749337428e-05 0.96874347276425 0.592920353982301 11.2 11 2 impaired limb coordination 0.00120943545014104 0.0109598203359775 0.968207959512307 0.592592592592593 11.2 11 2 abnormal bone trabecula morphology 0.0200820627665742 0.100877204196338 0.968207959512307 0.592592592592593 11.2 11 2 male infertility 1.95117444604392e-22 6.06693304316781e-20 0.967967351172468 0.592445328031809 11.2 11 2 hydroencephaly 3.33444942470376e-06 7.02918893555136e-05 0.966103159600324 0.591304347826087 11.2 11 2 abnormal myelopoiesis 0.00358840141433744 0.0264448350972528 0.965457368718238 0.590909090909091 11.2 11 2 decreased blood urea nitrogen level 0.00358840141433744 0.0264448350972528 0.965457368718238 0.590909090909091 11.2 11 2 decreased sensitivity to induced morbidity/mortality 0.00358840141433744 0.0264448350972528 0.965457368718238 0.590909090909091 11.2 11 2 increased body size 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 decreased cardiac output 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 abnormal retinal outer plexiform layer morphology 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 abnormal occipital bone morphology 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 failure of palatal shelf elevation 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 abnormal lipid level 7.90723425756367e-05 0.00112717737625728 0.964562598218963 0.590361445783133 11.2 11 2 reduced fertility 3.94903175117689e-07 1.05625983667231e-05 0.963854506456946 0.589928057553957 11.2 11 2 increased autoantibody level 0.0062276320396135 0.0410908082189352 0.963553113553114 0.58974358974359 11.2 11 2 decreased startle reflex 3.23092526494493e-06 6.83993752897917e-05 0.963553113553114 0.58974358974359 11.2 11 2 alopecia 2.67976867308358e-05 0.000444394971619694 0.963112128146453 0.589473684210526 11.2 11 2 infertility 9.13400845270475e-06 0.000169558552433605 0.961986997155628 0.588785046728972 11.2 11 2 abnormal oocyte morphology 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 overexpanded pulmonary alveoli 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 abnormal spleen red pulp morphology 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 abnormal nervous system development 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 abnormal bone marrow cavity morphology 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 abnormal interatrial septum morphology 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 hydroureter 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 abnormal melanosome morphology 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 coloboma 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 delayed heart development 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 abnormal locomotor behavior 4.36944902717639e-05 0.000675093444416227 0.95899945989738 0.58695652173913 11.2 11 2 abnormal bone mineralization 3.02377864086582e-06 6.42876014457584e-05 0.958705918587342 0.586776859504132 11.2 11 2 spleen hyperplasia 0.000219208661265445 0.0026861159847182 0.958525879917184 0.586666666666667 11.2 11 2 enlarged heart 1.3384963180949e-10 7.23806432882839e-09 0.957774684086528 0.586206896551724 11.2 11 2 abnormal parietal bone morphology 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 abnormal microglial cell morphology 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 decreased granulocyte number 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 focal hair loss 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 abnormal embryonic erythropoiesis 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 reduced male fertility 2.23176279848241e-10 1.16873893920526e-08 0.957278299176403 0.585903083700441 11.2 11 2 decreased circulating serum albumin level 2.50151551784131e-05 0.000419024905766347 0.957205596336031 0.585858585858586 11.2 11 2 thick epidermis 0.000372182458237402 0.00421778526134641 0.956969831410825 0.585714285714286 11.2 11 2 short ulna 0.00597279635127482 0.0401604186799081 0.956400545371913 0.585365853658537 11.2 11 2 hemopericardium 0.00597279635127482 0.0401604186799081 0.956400545371913 0.585365853658537 11.2 11 2 abnormal rib morphology 1.00373890932012e-06 2.44784366366058e-05 0.956105360018403 0.585185185185185 11.2 11 2 cleft secondary palate 4.21582796164786e-05 0.000655429503412441 0.955976608959958 0.585106382978723 11.2 11 2 abnormal coat/ hair morphology 0.00192477475812255 0.0162196808104765 0.955648658150709 0.584905660377358 11.2 11 2 neonatal lethality, incomplete penetrance 1.51576279119557e-11 9.54546821037718e-10 0.955174390826565 0.584615384615385 11.2 11 2 abnormal muscle physiology 7.11240152333126e-05 0.00103160925885053 0.954609533114663 0.584269662921348 11.2 11 2 arrest of spermatogenesis 0.000120131851650864 0.00161528638368391 0.953079710144928 0.583333333333333 11.2 11 2 short radius 0.0104034488180736 0.0610343842805613 0.953079710144928 0.583333333333333 11.2 11 2 abnormal digestive system morphology 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal nursing 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal startle reflex 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal cardiac muscle contractility 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal osteoblast morphology 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal superior cervical ganglion morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal enteric nervous system morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 absent optic nerve 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 altered tumor susceptibility 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 decreased synaptic depression 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal aorta elastic fiber morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal alisphenoid bone morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 loss of dopaminergic neurons 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal defecation 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal B cell proliferation 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 decreased prostaglandin level 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 decreased mammary gland epithelial cell proliferation 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal vitelline vein connection 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 muscular ventricular septal defect 0.00107982289671829 0.0100601477737331 0.953079710144927 0.583333333333333 11.2 11 2 female infertility 1.36504932002548e-11 8.70656457323944e-10 0.952055994022323 0.582706766917293 11.2 11 2 hunched posture 0.000203176046093167 0.00251279027542924 0.951356238698011 0.582278481012658 11.2 11 2 maternal effect 0.000608491295400117 0.00634642388808298 0.951047557244832 0.582089552238806 11.2 11 2 absent mature ovarian follicles 0.0182621202057802 0.093942764529764 0.948687637747946 0.580645161290323 11.2 11 2 abnormal retinal photoreceptor layer morphology 0.0182621202057802 0.093942764529764 0.948687637747946 0.580645161290323 11.2 11 2 abnormal spleen morphology 5.9711702224632e-08 1.92188901417201e-06 0.948384736203327 0.580459770114943 11.2 11 2 decreased respiratory quotient 0.00316811651944841 0.0237370175967709 0.947633540372671 0.58 11.2 11 2 abnormal sternum morphology 0.000583892604043437 0.00610265904436155 0.947159960392475 0.579710144927536 11.2 11 2 hyperkeratosis 0.000583892604043437 0.00610265904436155 0.947159960392475 0.579710144927536 11.2 11 2 ataxia 6.65834563412496e-09 2.54809765613628e-07 0.946339401020847 0.579207920792079 11.2 11 2 increased macrophage cell number 0.00176851991392745 0.0150143115559541 0.945913697286695 0.578947368421053 11.2 11 2 abnormal retinal outer nuclear layer morphology 0.00992232408012886 0.0594026020440927 0.945913697286695 0.578947368421053 11.2 11 2 small superior vagus ganglion 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 abnormal stationary movement 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased tumor incidence 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 osteoarthritis 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 increased left ventricle weight 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 abnormal sternebra morphology 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased circulating magnesium level 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased liver glycogen level 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 thin interventricular septum 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased lymphocyte cell number 4.05618756246375e-06 8.37325025861293e-05 0.944570069875776 0.578125 11.2 11 2 abnormal osteoclast physiology 0.000992601737312311 0.00938029098741372 0.944570069875776 0.578125 11.2 11 2 abnormal tooth morphology 0.000992601737312311 0.00938029098741372 0.944570069875776 0.578125 11.2 11 2 abnormal female meiosis 0.00302764090410282 0.0227187232246026 0.942606306736742 0.576923076923077 11.2 11 2 increased leukemia incidence 0.032388752774728 0.142596500048028 0.942606306736742 0.576923076923077 11.2 11 2 abnormal nerve conduction 0.032388752774728 0.142596500048028 0.942606306736742 0.576923076923077 11.2 11 2 abnormal vascular development 0.000949666525517816 0.00908575185471372 0.940702051571617 0.575757575757576 11.2 11 2 abnormal tooth development 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 dextrocardia 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 abnormal epidermis stratum basale morphology 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 decreased systemic arterial blood pressure 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 dilated heart atrium 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 cardiovascular system phenotype 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 myeloid hyperplasia 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 increased circulating insulin level 4.09655690842638e-07 1.0898593914129e-05 0.939464285714286 0.575 11.2 11 2 abnormal posture 0.000303072688144249 0.00353111621432703 0.939464285714286 0.575 11.2 11 2 impaired ovarian folliculogenesis 0.00944395656290754 0.0566068480728494 0.939464285714286 0.575 11.2 11 2 abnormal skin pigmentation 0.00944395656290754 0.0566068480728494 0.939464285714286 0.575 11.2 11 2 increased susceptibility to weight loss 0.00944395656290754 0.0566068480728494 0.939464285714286 0.575 11.2 11 2 abnormal tibia morphology 0.00520128297318937 0.0357408602094159 0.938595216069777 0.574468085106383 11.2 11 2 polyphagia 0.00288892773844542 0.02211140845964 0.937951460777548 0.574074074074074 11.2 11 2 decreased platelet aggregation 0.00288892773844542 0.02211140845964 0.937951460777548 0.574074074074074 11.2 11 2 abnormal long bone morphology 0.00161500668841567 0.0139490595049791 0.937455452601568 0.573770491803279 11.2 11 2 increased double-negative T cell number 0.00161500668841567 0.0139490595049791 0.937455452601568 0.573770491803279 11.2 11 2 increased startle reflex 0.000164577633999657 0.00211569439056406 0.936251657477842 0.573033707865168 11.2 11 2 increased sensitivity to xenobiotic induced morbidity/mortality 3.05162589561092e-05 0.000493978208106856 0.935750988142293 0.572727272727273 11.2 11 2 decreased neutrophil cell number 1.74606201008225e-05 0.000304795035093305 0.935624037797951 0.572649572649573 11.2 11 2 impaired coordination 2.44054250033861e-13 1.95833853857816e-11 0.934978278820953 0.572254335260116 11.2 11 2 limb grasping 1.14983212425949e-07 3.48805781597009e-06 0.933629103815439 0.571428571428571 11.2 11 2 small ovary 0.000157326296083957 0.00204894848957509 0.933629103815439 0.571428571428571 11.2 11 2 increased body weight 4.26172549465024e-09 1.72374669397439e-07 0.933629103815439 0.571428571428571 11.2 11 2 abnormal cardiovascular system physiology 5.49366330766752e-06 0.000106761620920492 0.933629103815439 0.571428571428571 11.2 11 2 cardiac hypertrophy 8.95687281569297e-05 0.00124470509100761 0.933629103815439 0.571428571428571 11.2 11 2 increased food intake 0.000276988007696427 0.00332051888744512 0.933629103815439 0.571428571428571 11.2 11 2 short mandible 0.00275279343466592 0.0211350723517915 0.933629103815439 0.571428571428571 11.2 11 2 abnormal long bone hypertrophic chondrocyte zone 0.0049500870959743 0.0341562875207658 0.933629103815439 0.571428571428571 11.2 11 2 increased fluid intake 0.0049500870959743 0.0341562875207658 0.933629103815439 0.571428571428571 11.2 11 2 impaired adaptive thermogenesis 0.016441622710922 0.0868334108140518 0.933629103815439 0.571428571428571 11.2 11 2 rib bifurcation 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 small superior cervical ganglion 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 abnormal ovulation 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 absent corpus callosum 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 increased bone resorption 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 corneal vascularization 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 abnormal associative learning 0.0582681651306671 0.210671599945544 0.933629103815439 0.571428571428571 11.2 11 2 abnormal bile salt homeostasis 0.0582681651306671 0.210671599945544 0.933629103815439 0.571428571428571 11.2 11 2 increased keratinocyte proliferation 0.0582681651306671 0.210671599945544 0.933629103815439 0.571428571428571 11.2 11 2 translucent skin 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal placing response 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 extended life span 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 absent visceral yolk sac blood islands 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased vascular permeability 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 intestinal obstruction 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal uterus development 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal squamosal bone morphology 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased CNS synapse formation 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal iris pigmentation 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 premature hair loss 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 increased pulmonary respiratory rate 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased response to antigen 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased double-positive T cell number 8.55861021703634e-05 0.00119941086844383 0.931295031055901 0.57 11.2 11 2 respiratory failure 1.66039372464976e-06 3.75475399096935e-05 0.930537616716713 0.56953642384106 11.2 11 2 increased lung adenocarcinoma incidence 0.00470468558619782 0.0325532834371824 0.929052490561442 0.568627450980392 11.2 11 2 abnormal dendritic spine morphology 0.00470468558619782 0.0325532834371824 0.929052490561442 0.568627450980392 11.2 11 2 increased liver weight 0.000252256110976979 0.0030313385316678 0.928324392998306 0.568181818181818 11.2 11 2 teratozoospermia 0.000252256110976979 0.0030313385316678 0.928324392998306 0.568181818181818 11.2 11 2 muscular atrophy 0.00851272559071981 0.0514836815501993 0.928324392998306 0.568181818181818 11.2 11 2 abnormal skeleton development 0.00044482077259852 0.00492869341576311 0.927865961199295 0.567901234567901 11.2 11 2 increased granulocyte number 0.000786777799909115 0.00772035415098194 0.927320799059929 0.567567567567568 11.2 11 2 increased brown adipose tissue amount 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 abnormal branching of the mammary ductal tree 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 abnormal breathing pattern 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 abnormal hair follicle development 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 increased trabecular bone volume 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 postnatal lethality, complete penetrance 4.63060348733507e-14 4.43024083644077e-12 0.926977601132816 0.567357512953368 11.2 11 2 cachexia 7.79778590572018e-05 0.0011147696804873 0.926896201624462 0.567307692307692 11.2 11 2 intracranial hemorrhage 0.00249064836161321 0.0194520810031801 0.925848861283644 0.566666666666667 11.2 11 2 enhanced paired-pulse facilitation 0.0288411769783738 0.131516824443089 0.925848861283644 0.566666666666667 11.2 11 2 hyperactivity 2.08593754445655e-13 1.72958988061189e-11 0.924821282081331 0.566037735849057 11.2 11 2 deafness 0.000130368787344671 0.00174350730387026 0.924198506807203 0.565656565656566 11.2 11 2 abnormal coat appearance 0.00132811781872178 0.0118200109984631 0.923480961382663 0.565217391304348 11.2 11 2 fragile skeleton 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 abnormal cranial nerve morphology 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 hypotension 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 pancreas inflammation 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 abnormal cardiovascular development 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 decreased epididymis weight 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 abnormal palatal shelf fusion at midline 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 cardiac fibrosis 0.000403314790376324 0.0045498663993701 0.922645232005846 0.564705882352941 11.2 11 2 abnormal lens fiber morphology 0.0147036902502076 0.0784039217521787 0.92165949992037 0.564102564102564 11.2 11 2 abnormal circulating hormone level 0.0147036902502076 0.0784039217521787 0.92165949992037 0.564102564102564 11.2 11 2 decreased circulating calcium level 0.00423530460731394 0.0296062900972343 0.92089779785432 0.563636363636364 11.2 11 2 abnormal gait 4.09560028283511e-11 2.41786452720062e-09 0.920032563468613 0.563106796116505 11.2 11 2 decreased B cell number 6.66675468586199e-08 2.09918383304832e-06 0.920032563468612 0.563106796116505 11.2 11 2 retinal degeneration 0.000207394449233499 0.00255392917063528 0.919041149068323 0.5625 11.2 11 2 decreased caudal vertebrae number 0.00224462115444675 0.0184273766392287 0.919041149068323 0.5625 11.2 11 2 curly tail 0.00763380755166843 0.048134591342903 0.919041149068323 0.5625 11.2 11 2 abnormal lymphatic vessel morphology 0.0271523474866811 0.124043093430889 0.919041149068323 0.5625 11.2 11 2 neonatal lethality 0.0271523474866811 0.124043093430889 0.919041149068323 0.5625 11.2 11 2 failure of tooth eruption 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal mouth morphology 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 disorganized retinal layers 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal intestinal absorption 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 white spotting 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal epicardium morphology 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 increased pancreatic beta cell number 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal amnion morphology 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal level of surface class II molecules 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal intestinal lipid absorption 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 decreased skeletal muscle weight 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 decreased midbrain size 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 increased circulating HDL cholesterol level 0.000112457820941221 0.00151619961838097 0.918068618751849 0.561904761904762 11.2 11 2 neonatal lethality, complete penetrance 1.9449533098527e-15 2.52719990409918e-13 0.917249645853765 0.56140350877193 11.2 11 2 sparse hair 0.000642807576048992 0.00668418510587687 0.916550522648084 0.560975609756098 11.2 11 2 scaly skin 0.0138793279444382 0.0755085939650392 0.916550522648084 0.560975609756098 11.2 11 2 lethality at weaning, incomplete penetrance 0.0138793279444382 0.0755085939650392 0.916550522648084 0.560975609756098 11.2 11 2 respiratory distress 9.9031771284493e-07 2.42701015832686e-05 0.916089828743762 0.560693641618497 11.2 11 2 abnormal skin morphology 0.00212824338550152 0.0177485748439069 0.915946734424995 0.560606060606061 11.2 11 2 abnormal locomotor activation 0.000346430832697863 0.00394392080702945 0.915674697972835 0.56043956043956 11.2 11 2 postnatal lethality 1.71725960272213e-06 3.83110606436888e-05 0.915350220758812 0.560240963855422 11.2 11 2 abnormal neurocranium morphology 0.00113647580663306 0.0103363201791581 0.91495652173913 0.56 11.2 11 2 increased monocyte cell number 0.00018736493211197 0.00234796105102532 0.91495652173913 0.56 11.2 11 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0510951305517133 0.198862688819956 0.91495652173913 0.56 11.2 11 2 decreased T cell number 2.83444264579703e-06 6.05208247332198e-05 0.913332818949886 0.559006211180124 11.2 11 2 abnormal endoderm development 0.0255334584959527 0.117077378817847 0.913034344172452 0.558823529411765 11.2 11 2 increased susceptibility to weight gain 0.0255334584959527 0.117077378817847 0.913034344172452 0.558823529411765 11.2 11 2 increased inflammatory response 0.000312139473274039 0.00362825672789333 0.911516835567179 0.557894736842105 11.2 11 2 abnormal snout morphology 0.00681922018536104 0.044173984924702 0.911186096512183 0.557692307692308 11.2 11 2 abnormal skin condition 0.00681922018536104 0.044173984924702 0.911186096512183 0.557692307692308 11.2 11 2 abnormal maternal nurturing 0.00359330824638047 0.0264448350972528 0.910671011098666 0.557377049180328 11.2 11 2 increased osteoclast cell number 0.00359330824638047 0.0264448350972528 0.910671011098666 0.557377049180328 11.2 11 2 abnormal skeleton morphology 8.70145332395844e-05 0.00121600365973857 0.909273561976776 0.556521739130435 11.2 11 2 improved glucose tolerance 3.8325017327599e-07 1.03623348480872e-05 0.908621181391811 0.556122448979592 11.2 11 2 abnormal mandible morphology 0.00643770474611675 0.0423645252803318 0.907694962042788 0.555555555555556 11.2 11 2 axon degeneration 0.00643770474611675 0.0423645252803318 0.907694962042788 0.555555555555556 11.2 11 2 rectal prolapse 0.0477721152849204 0.186697779687729 0.907694962042788 0.555555555555556 11.2 11 2 cryptorchism 0.0477721152849204 0.186697779687729 0.907694962042788 0.555555555555556 11.2 11 2 abnormal skin appearance 0.0477721152849204 0.186697779687729 0.907694962042788 0.555555555555556 11.2 11 2 decreased heart weight 0.000966867316359681 0.00923256218596816 0.907694962042788 0.555555555555556 11.2 11 2 abnormal neuromuscular synapse morphology 0.00180672416870723 0.0152864842505416 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ovarian follicle morphology 0.0123326014691303 0.0698779089905028 0.907694962042788 0.555555555555556 11.2 11 2 cardiomyopathy 0.0123326014691303 0.0698779089905028 0.907694962042788 0.555555555555556 11.2 11 2 abnormal limb bone morphology 0.0239893400769825 0.110263055188876 0.907694962042788 0.555555555555556 11.2 11 2 underdeveloped hair follicles 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 abnormal retinal rod cell morphology 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 abnormal Peyer's patch follicle morphology 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 acidosis 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 decreased activity of thyroid 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 abnormal neutrophil morphology 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 jerky movement 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 decreased fluid intake 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 crypts of Lieberkuhn abscesses 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 absent parathyroid glands 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 small geniculate ganglion 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal kindling response 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 multifocal hepatic necrosis 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased level of surface class I molecules 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal taste sensitivity 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal thymus lobule morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal NMDA-mediated synaptic currents 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 genetic imprinting 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal lens capsule morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal abdominal wall morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 priapism 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 premature bone ossification 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ovary physiology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased cellular sensitivity to ionizing radiation 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal optic chiasm morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 multiflagellated sperm 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal hyoid bone lesser horn morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal telomere morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 retropulsion 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ventricle myocardium morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 shortened ST segment 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased airway resistance 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ureteric bud invasion 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased bone trabecular spacing 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 increased myeloid cell number 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 trigeminal neuroma 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ductus venosus valve topology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal coronary sinus connection 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 cerebellum atrophy 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased bone mineral density of femur 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 increased bone mineralization 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 increased endoplasmic reticulum stress 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased platelet dense granule number 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal spatial learning 5.62999016343225e-06 0.000108985218144262 0.902126281294059 0.552147239263804 11.2 11 2 abnormal spermiogenesis 0.00572686792539727 0.0392440329598504 0.901434996787321 0.551724137931034 11.2 11 2 decreased retinal photoreceptor cell number 0.0446362416401039 0.175130364479114 0.901434996787321 0.551724137931034 11.2 11 2 organ of Corti degeneration 0.0109274644745658 0.0636582385959774 0.900285207250602 0.551020408163265 11.2 11 2 abnormal epidermis stratum corneum morphology 0.0109274644745658 0.0636582385959774 0.900285207250602 0.551020408163265 11.2 11 2 no abnormal phenotype detected 5.8466148661445e-50 5.81738179181378e-47 0.900265988866415 0.551008645533141 11.2 11 2 abnormal pancreatic beta cell morphology 0.0211322536457966 0.10167597861493 0.89861801242236 0.55 11.2 11 2 abnormal basioccipital bone morphology 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 anencephaly 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal hair texture 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal fibula morphology 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal optic stalk morphology 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal heart electrocardiography waveform feature 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 decreased muscle cell glucose uptake 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 increased thermal nociceptive threshold 0.000731522055705982 0.00735216611542881 0.89772029213023 0.549450549450549 11.2 11 2 abnormal object recognition memory 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 autoimmune response 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 decreased neuronal precursor cell number 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 decreased double-negative T cell number 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 abnormal intestine physiology 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 skin edema 0.0198186250386038 0.100712624685449 0.894727891156463 0.547619047619048 11.2 11 2 abnormal vibrissa morphology 0.0198186250386038 0.100712624685449 0.894727891156463 0.547619047619048 11.2 11 2 increased T cell number 0.00114308598990611 0.0103774686127426 0.891191417278374 0.545454545454545 11.2 11 2 obese 0.00226067953786851 0.0185286337741282 0.891191417278374 0.545454545454545 11.2 11 2 abnormal joint morphology 0.00908058491268016 0.0546262514396418 0.891191417278374 0.545454545454545 11.2 11 2 abnormal circadian rhythm 0.018579417778068 0.0951932064324285 0.891191417278374 0.545454545454545 11.2 11 2 abnormal ovarian folliculogenesis 0.0389206455136591 0.162642205394726 0.891191417278374 0.545454545454545 11.2 11 2 abnormal skeleton physiology 0.0389206455136591 0.162642205394726 0.891191417278374 0.545454545454545 11.2 11 2 abnormal abdominal fat pad morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal cochlear sensory epithelium morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal limb posture 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal basement membrane morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 decreased circulating estradiol level 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal sperm midpiece morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal cerebral cortex pyramidal cell morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 pulmonary vascular congestion 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 increased circulating creatine kinase level 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 rough coat 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 increased mammary gland tumor incidence 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 increased bone volume 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 premature suture closure 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal awl hair morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal glossopharyngeal ganglion morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 failure of somite differentiation 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal primary sex determination 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal larynx morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal bronchiole morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal nerve fiber response 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal spinal cord ventral horn morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal superovulation 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 decreased palatine bone horizontal plate size 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 shortened PR interval 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal extraembryonic ectoderm morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 decreased core body temperature 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal phrenic nerve innervation pattern to diaphragm 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 thin hypoglossal nerve 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 decreased B cell proliferation 0.00212982898126883 0.0177485748439069 0.88931126660901 0.544303797468354 11.2 11 2 abnormal sleep pattern 0.0174121748121433 0.090993245473123 0.887962462867945 0.543478260869565 11.2 11 2 weight loss 8.1925364490799e-06 0.00015322507080516 0.886947648624667 0.542857142857143 11.2 11 2 increased carcinoma incidence 0.0363300134906767 0.157991098877724 0.886947648624667 0.542857142857143 11.2 11 2 abnormal colon morphology 0.00801222630878174 0.049029306133074 0.886156437519739 0.542372881355932 11.2 11 2 abnormal thoracic vertebrae morphology 0.00801222630878174 0.049029306133074 0.886156437519739 0.542372881355932 11.2 11 2 decreased metastatic potential 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 curly vibrissae 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 abnormal retinal ganglion layer morphology 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 abnormal truncus arteriosus septation 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 circling 0.00177826462606375 0.0150713228529253 0.884201680672269 0.541176470588235 11.2 11 2 abnormal vocalization 0.0339072746362343 0.148886753146748 0.883162665771361 0.540540540540541 11.2 11 2 increased body length 0.0152819949232411 0.0813132884953205 0.88227950310559 0.54 11.2 11 2 abnormal nervous system physiology 0.00036327206717828 0.00412620669911402 0.880858763165001 0.539130434782609 11.2 11 2 increased circulating glucose level 8.54503109456435e-05 0.00119941086844383 0.880657239769173 0.539007092198582 11.2 11 2 abnormal heart looping 0.0316437221857804 0.142596500048028 0.879765886287626 0.538461538461538 11.2 11 2 decreased B-1 B cell number 0.0316437221857804 0.142596500048028 0.879765886287626 0.538461538461538 11.2 11 2 abnormal B cell differentiation 0.00148194337134775 0.0128443698126394 0.879765886287625 0.538461538461538 11.2 11 2 abnormal brain wave pattern 0.014312803719923 0.0764835644539385 0.879765886287625 0.538461538461538 11.2 11 2 abnormal leukocyte cell number 0.0729192379581963 0.248815643924573 0.879765886287625 0.538461538461538 11.2 11 2 short premaxilla 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 short hair 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 excessive scratching 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal digestion 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal pulmonary alveolus epithelial cell morphology 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal lung interstitium morphology 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal bile duct development 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal soleus morphology 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 tracheoesophageal fistula 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 small interparietal bone 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 increased cochlear inner hair cell number 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 empty decidua capsularis 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 increased prostaglandin level 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 increased leukocyte cell number 7.59581445644039e-05 0.00108902527149253 0.878899121867638 0.537931034482759 11.2 11 2 abnormal lung morphology 0.000322391974637497 0.00373869481077284 0.878709744767472 0.53781512605042 11.2 11 2 abnormal femur morphology 0.00622072517714032 0.0410908082189352 0.877890052841383 0.537313432835821 11.2 11 2 abnormal response/metabolism to endogenous compounds 0.00275286972541927 0.0211350723517915 0.876700499924254 0.536585365853659 11.2 11 2 shortened head 0.0675961019061281 0.240551221017874 0.875277284826974 0.535714285714286 11.2 11 2 abnormal retinal inner nuclear layer morphology 0.0675961019061281 0.240551221017874 0.875277284826974 0.535714285714286 11.2 11 2 enhanced coordination 0.0675961019061281 0.240551221017874 0.875277284826974 0.535714285714286 11.2 11 2 decreased insulin secretion 0.00214328544463663 0.0177899182506223 0.871387163561077 0.533333333333333 11.2 11 2 abnormal long bone epiphyseal plate morphology 0.011000827320648 0.0639358830843734 0.871387163561076 0.533333333333333 11.2 11 2 abnormal eye physiology 0.011000827320648 0.0639358830843734 0.871387163561076 0.533333333333333 11.2 11 2 abnormal hair cycle 0.0626877441106527 0.224529537041395 0.871387163561076 0.533333333333333 11.2 11 2 salivary gland inflammation 0.0626877441106527 0.224529537041395 0.871387163561076 0.533333333333333 11.2 11 2 interdigital webbing 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal prostate gland morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal epidermis stratum spinosum morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 no suckling reflex 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 audiogenic seizures 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal seizure response to electrical stimulation 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal respiratory system morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal zygomatic bone morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 liver vascular congestion 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 bicuspid aortic valve 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 increased sensitivity to induced morbidity/mortality 1.71255311381599e-05 0.000299998300747695 0.870203213610586 0.532608695652174 11.2 11 2 neuron degeneration 0.0240029927174981 0.110263055188876 0.869069644509053 0.531914893617021 11.2 11 2 decreased food intake 0.00423863403317484 0.0296062900972343 0.86862960924601 0.531645569620253 11.2 11 2 abnormal lumbar vertebrae morphology 0.0581599784227252 0.210671599945544 0.867983307453416 0.53125 11.2 11 2 abnormal depression-related behavior 0.0581599784227252 0.210671599945544 0.867983307453416 0.53125 11.2 11 2 abnormal auditory brainstem response waveform shape 0.0581599784227252 0.210671599945544 0.867983307453416 0.53125 11.2 11 2 increased T cell derived lymphoma incidence 0.0224032478065153 0.105827423614097 0.866941310685765 0.530612244897959 11.2 11 2 abnormal motor capabilities/coordination/movement 0.000301934411833614 0.00352611196918364 0.866436100131752 0.53030303030303 11.2 11 2 abnormal cervical vertebrae morphology 0.0209117173604106 0.100877204196338 0.86497990500548 0.529411764705882 11.2 11 2 abnormal response to novel object 0.0209117173604106 0.100877204196338 0.86497990500548 0.529411764705882 11.2 11 2 short maxilla 0.0539812309085788 0.198862688819956 0.86497990500548 0.529411764705882 11.2 11 2 increased width of hypertrophic chondrocyte zone 0.0539812309085788 0.198862688819956 0.86497990500548 0.529411764705882 11.2 11 2 abnormal skin physiology 0.0539812309085788 0.198862688819956 0.86497990500548 0.529411764705882 11.2 11 2 abnormal heart rate 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal cranial suture morphology 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal duodenum morphology 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal involuntary movement 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal tarsal bone morphology 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 common atrium 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 decreased body fat mass 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal placenta development 0.0195211451524947 0.0994039888778517 0.863166529942576 0.528301886792453 11.2 11 2 abnormal heart left ventricle morphology 0.00740300667543191 0.0468574531937325 0.862310213940649 0.527777777777778 11.2 11 2 abnormal neuron differentiation 0.0010701379318231 0.0100579673992312 0.860689330079858 0.526785714285714 11.2 11 2 impaired righting response 0.00253312838668009 0.0197528428271684 0.859921542987904 0.526315789473684 11.2 11 2 abnormal frontal bone morphology 0.0465573947563121 0.182380345600514 0.859921542987904 0.526315789473684 11.2 11 2 abnormal reproductive system physiology 0.0465573947563121 0.182380345600514 0.859921542987904 0.526315789473684 11.2 11 2 flaky skin 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 stereotypic behavior 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 abnormal metatarsal bone morphology 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 increased susceptibility to ischemic brain injury 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 increased hemoglobin content 0.0158890239791725 0.0840041384658697 0.858464048847247 0.525423728813559 11.2 11 2 abnormal motor coordination/ balance 0.00222673775366281 0.0183107773958223 0.858184327749545 0.525252525252525 11.2 11 2 abnormal male meiosis 0.0148381913120323 0.079036404472549 0.857102128092862 0.524590163934426 11.2 11 2 abnormal anxiety-related response 0.128581800195695 0.377387385917969 0.855826678497486 0.523809523809524 11.2 11 2 dry skin 0.128581800195695 0.377387385917969 0.855826678497486 0.523809523809524 11.2 11 2 abnormal stapes morphology 0.128581800195695 0.377387385917969 0.855826678497486 0.523809523809524 11.2 11 2 increased T cell proliferation 0.00172055026024774 0.0147074528260009 0.855099553027225 0.523364485981308 11.2 11 2 abnormal suckling behavior 0.00436789373329054 0.0303072124450773 0.854058441558442 0.522727272727273 11.2 11 2 hypertension 0.0373922611693777 0.160523478223868 0.854058441558442 0.522727272727273 11.2 11 2 abnormal gametogenesis 0.0373922611693777 0.160523478223868 0.854058441558442 0.522727272727273 11.2 11 2 abnormal photoreceptor outer segment morphology 0.0373922611693777 0.160523478223868 0.854058441558442 0.522727272727273 11.2 11 2 increased total body fat amount 0.00053220863691736 0.00560961434038954 0.853504218040234 0.522388059701492 11.2 11 2 lung inflammation 0.000499426436237355 0.00534332585006633 0.852966295213738 0.522058823529412 11.2 11 2 abnormal carpal bone morphology 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 bidirectional circling 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 failure of embryo implantation 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 abnormal postnatal growth 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 abnormal crista ampullaris morphology 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 abnormal lens development 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 increased B cell number 0.0012465031055611 0.0112343350546494 0.851836810532463 0.521367521367521 11.2 11 2 abnormal intestinal epithelium morphology 0.0323605319204449 0.142596500048028 0.850964026915114 0.520833333333333 11.2 11 2 abnormal cardiovascular system morphology 0.0323605319204449 0.142596500048028 0.850964026915114 0.520833333333333 11.2 11 2 abnormal phalanx morphology 0.0323605319204449 0.142596500048028 0.850964026915114 0.520833333333333 11.2 11 2 abnormal nest building behavior 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 abnormal primitive streak morphology 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 abnormal feces composition 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 diaphragmatic hernia 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 increased cellular sensitivity to ionizing radiation 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 abnormal response to infection 0.00805223249441426 0.049213583120038 0.84794795188301 0.518987341772152 11.2 11 2 reduced long term potentiation 0.00198744383208394 0.0166456785599623 0.846101375332742 0.517857142857143 11.2 11 2 seizures 0.00186167302322757 0.0157246575391463 0.845589517271439 0.517543859649123 11.2 11 2 cochlear ganglion degeneration 0.0226577401633958 0.106755968333675 0.845095309488113 0.517241379310345 11.2 11 2 abnormal circulating glucose level 0.0921959521911535 0.290484396549074 0.845095309488113 0.517241379310345 11.2 11 2 short sternum 0.0921959521911535 0.290484396549074 0.845095309488113 0.517241379310345 11.2 11 2 enlarged epididymis 0.0921959521911535 0.290484396549074 0.845095309488113 0.517241379310345 11.2 11 2 impaired swimming 0.017108832892584 0.0901657241955568 0.841680782985131 0.515151515151515 11.2 11 2 abnormal locomotor coordination 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 abnormal T cell subpopulation ratio 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 increased osteoblast cell number 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 diarrhea 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 abnormal T cell differentiation 0.00385344540835733 0.0279459051116293 0.841190578685198 0.514851485148515 11.2 11 2 cochlear outer hair cell degeneration 0.0138875102468364 0.0755085939650392 0.839617839889579 0.513888888888889 11.2 11 2 failure of heart looping 0.0622559974621349 0.223304677270455 0.837872272654882 0.512820512820513 11.2 11 2 altered response to myocardial infarction 0.0495965052288343 0.193675520811186 0.835079365079365 0.511111111111111 11.2 11 2 abnormal hair follicle morphology 0.0256903837770372 0.117688452385599 0.829892536724835 0.507936507936508 11.2 11 2 abnormal epidermal layer morphology 0.0207534209897571 0.100877204196338 0.828764965343415 0.507246376811594 11.2 11 2 decreased IgM level 0.00785932445193734 0.0483734513299968 0.825347377857463 0.505154639175258 11.2 11 2 abnormal dendritic cell physiology 0.00559662814952701 0.0384044483364095 0.824560283276252 0.504672897196262 11.2 11 2 short femur 0.0141285703800129 0.0756193001805988 0.816925465838509 0.5 11.2 11 2 impaired fertilization 0.0266219987489543 0.121844014513383 0.816925465838509 0.5 11.2 11 2 decreased eosinophil cell number 0.0330329945994165 0.145304286588945 0.816925465838509 0.5 11.2 11 2 abnormal seminal vesicle morphology 0.0442536195932715 0.173766185853611 0.816925465838509 0.5 11.2 11 2 cochlear hair cell degeneration 0.0695496564668103 0.245338458517196 0.816925465838509 0.5 11.2 11 2 embryonic lethality, incomplete penetrance 0.0695496564668103 0.245338458517196 0.816925465838509 0.5 11.2 11 2 abnormal cartilage morphology 0.0751457098490352 0.252744604400809 0.816925465838509 0.5 11.2 11 2 abnormal spleen white pulp morphology 0.0751457098490352 0.252744604400809 0.816925465838509 0.5 11.2 11 2 abnormal cytotoxic T cell physiology 0.0751457098490352 0.252744604400809 0.816925465838509 0.5 11.2 11 2 abnormal uterus morphology 0.0952189796314391 0.299629616487293 0.816925465838509 0.5 11.2 11 2 reduced long term depression 0.0952189796314391 0.299629616487293 0.816925465838509 0.5 11.2 11 2 decreased osteoblast cell number 0.103222308368638 0.322975461719479 0.816925465838509 0.5 11.2 11 2 abnormal circulating cholesterol level 0.132405407460397 0.377387385917969 0.816925465838509 0.5 11.2 11 2 abnormal foregut morphology 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 decreased body height 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 abnormal vasodilation 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 apnea 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 prolonged QT interval 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 decreased ovulation rate 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 increased circulating total protein level 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 abnormal long bone epiphysis morphology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal oogenesis 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal tracheal cartilage morphology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal female reproductive system physiology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal retinal layer morphology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 decreased susceptibility to viral infection induced morbidity/mortality 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal dopamine level 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal Peyer's patch T cell area morphology 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal hyoid bone morphology 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 decreased skin tensile strength 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal response to tactile stimuli 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal mammary gland morphology 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 thick dermal layer 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 increased circulating glycerol level 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 decreased heart rate variability 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 darkened coat color 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 decreased mast cell number 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 mixed cellular infiltration to dermis 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 reduced male mating frequency 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 abnormal extraembryonic endoderm formation 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 large intestinal inflammation 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 small epididymis 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 abnormal epididymis epithelium morphology 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 loose skin 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 decreased adipocyte glucose uptake 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 abnormal adrenal gland secretion 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 absent otoliths 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal kidney medulla morphology 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal voluntary movement 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal pancreas development 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal maternal decidual layer morphology 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 ear inflammation 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 interstitial pneumonia 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 increased papilloma incidence 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 increased circulating parathyroid hormone level 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 abnormal gastrocnemius morphology 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 decreased left ventricle systolic pressure 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 stria vascularis degeneration 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 small parietal bone 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 abnormal palatine bone morphology 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 hydrometra 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 impaired behavioral response to cocaine 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 abnormal aorta elastic tissue morphology 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 absent maxillary shelf 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 absent trophoblast giant cells 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal PNS synaptic transmission 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 delayed dark adaptation 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal tibialis anterior morphology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 lymphedema 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 cochlear ganglion hypoplasia 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal submandibular gland morphology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 decreased cochlear inner hair cell number 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal cochlear inner hair cell physiology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 decreased thyroxine level 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal developmental vascular remodeling 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 increased platelet aggregation 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 ventricular premature beat 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 increased serotonin level 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 aorta stenosis 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 sinus bradycardia 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal pulmonary interalveolar septum morphology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 decreased macrophage cytokine production 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 absent corpus luteum 0.0513462725928626 0.198862688819956 0.816925465838509 0.5 11.2 11 2 increased bone marrow cell number 0.0879198744460336 0.279489696721417 0.816925465838509 0.5 11.2 11 2 abnormal heart tube morphology 0.121704160271655 0.369939039549948 0.816925465838509 0.5 11.2 11 2 delayed eyelid opening 0.121704160271655 0.369939039549948 0.816925465838509 0.5 11.2 11 2 abnormal microglial cell physiology 0.121704160271655 0.369939039549948 0.816925465838509 0.5 11.2 11 2 abnormal Schwann cell morphology 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 small seminal vesicle 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 no spontaneous movement 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 abnormal ocular fundus morphology 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 increased anxiety-related response 0.00326225923435445 0.0244056235953585 0.811048304213772 0.496402877697842 11.2 11 2 abnormal eye electrophysiology 0.00596356211451711 0.0401604186799081 0.810174015707613 0.495867768595041 11.2 11 2 abnormal skeletal muscle fiber morphology 0.0337034748505866 0.148122603694054 0.805419473361911 0.492957746478873 11.2 11 2 internal hemorrhage 0.0389360535929886 0.162642205394726 0.804732548437935 0.492537313432836 11.2 11 2 increased sarcoma incidence 0.0759720576862424 0.252744604400809 0.800253517556091 0.489795918367347 11.2 11 2 abnormal T-helper 1 physiology 0.0820334005261114 0.26296144820709 0.799544072948328 0.48936170212766 11.2 11 2 decreased osteoclast cell number 0.0886352793900918 0.281045579965396 0.798771566597653 0.488888888888889 11.2 11 2 lethality at weaning, complete penetrance 0.0886352793900918 0.281045579965396 0.798771566597653 0.488888888888889 11.2 11 2 decreased exploration in new environment 0.0275021219673152 0.12552574017192 0.797474859509021 0.488095238095238 11.2 11 2 acanthosis 0.112300557580738 0.347231369772637 0.795978659022137 0.487179487179487 11.2 11 2 impaired macrophage chemotaxis 0.112300557580738 0.347231369772637 0.795978659022137 0.487179487179487 11.2 11 2 abnormal long bone metaphysis morphology 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal pancreatic beta cell physiology 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal calcium ion homeostasis 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal humerus morphology 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal intestinal goblet cell morphology 0.132076552996347 0.377387385917969 0.793584738243123 0.485714285714286 11.2 11 2 impaired behavioral response to xenobiotic 0.132076552996347 0.377387385917969 0.793584738243123 0.485714285714286 11.2 11 2 absent vibrissae 0.143466094739622 0.377387385917969 0.792170148691888 0.484848484848485 11.2 11 2 increased eosinophil cell number 0.0606095859732423 0.21897798853804 0.790573031456622 0.483870967741935 11.2 11 2 increased lung adenoma incidence 0.156031480799892 0.377387385917969 0.790573031456622 0.483870967741935 11.2 11 2 abnormal middle ear morphology 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 aphagia 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 stomach inflammation 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 abnormal CD8-positive, alpha-beta T cell physiology 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 increased retinal apoptosis 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 abnormal cochlea morphology 0.0816309921623678 0.261840223086899 0.78666896710375 0.481481481481481 11.2 11 2 abnormal brain commissure morphology 0.185368013188472 0.435208053616163 0.78666896710375 0.481481481481481 11.2 11 2 decreased susceptibility to pharmacologically induced seizures 0.185368013188472 0.435208053616163 0.78666896710375 0.481481481481481 11.2 11 2 abnormal hair growth 0.0880431271914032 0.279524287030779 0.785505255613951 0.480769230769231 11.2 11 2 increased susceptibility to injury 0.0880431271914032 0.279524287030779 0.785505255613951 0.480769230769231 11.2 11 2 abnormal inner ear vestibule morphology 0.202567954558629 0.47172777602813 0.784248447204969 0.48 11.2 11 2 abnormal trabecular bone morphology 0.0169668053783927 0.0895120432211067 0.78260086643353 0.478991596638655 11.2 11 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0559261946076256 0.203089648301414 0.782407488408713 0.47887323943662 11.2 11 2 blistering 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 abnormal circulating insulin level 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 conjunctivitis 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 abnormal corneal stroma morphology 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 abnormal basicranium morphology 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 decreased IgG level 0.0222218133630243 0.105827423614097 0.780127021431369 0.477477477477477 11.2 11 2 skin lesions 0.0747634065013659 0.252744604400809 0.778024253179533 0.476190476190476 11.2 11 2 abnormal optic nerve morphology 0.129656038574601 0.377387385917969 0.778024253179533 0.476190476190476 11.2 11 2 increased incidence of induced tumors 0.243498428009043 0.54666276143727 0.778024253179533 0.476190476190476 11.2 11 2 decreased cochlear outer hair cell number 0.243498428009043 0.54666276143727 0.778024253179533 0.476190476190476 11.2 11 2 abnormal clavicle morphology 0.243498428009043 0.54666276143727 0.778024253179533 0.476190476190476 11.2 11 2 abnormal female reproductive system morphology 0.14039361716847 0.377387385917969 0.776079192546584 0.475 11.2 11 2 perinatal lethality 0.14039361716847 0.377387385917969 0.776079192546584 0.475 11.2 11 2 abnormal compact bone morphology 0.152152795352781 0.377387385917969 0.773929388689114 0.473684210526316 11.2 11 2 short vibrissae 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 unresponsive to tactile stimuli 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 abnormal long term depression 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 abnormal nasal septum morphology 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 maternal imprinting 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 abnormal photoreceptor inner segment morphology 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 decreased fertilization frequency 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 shortened RR interval 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 right-sided stomach 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 head tilt 0.165054381796528 0.395351732998425 0.77154071773637 0.472222222222222 11.2 11 2 decreased anxiety-related response 0.0231598740394097 0.106755968333675 0.770433772660708 0.471544715447154 11.2 11 2 impaired synaptic plasticity 0.179238349291607 0.424018443997026 0.768871026671538 0.470588235294118 11.2 11 2 decreased pancreatic beta cell number 0.179238349291607 0.424018443997026 0.768871026671538 0.470588235294118 11.2 11 2 abnormal glutamate-mediated receptor currents 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 absence seizures 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 increased regulatory T cell number 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 abnormal circulating chemokine level 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 abnormal survival 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 abnormal electroretinogram waveform feature 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 cochlear inner hair cell degeneration 0.116885458858506 0.358290300567509 0.768871026671538 0.470588235294118 11.2 11 2 abnormal long term potentiation 0.194868030040671 0.455791466597243 0.765867624223602 0.46875 11.2 11 2 increased circulating corticosterone level 0.147134999353293 0.377387385917969 0.762463768115942 0.466666666666667 11.2 11 2 abnormal response to new environment 0.212135545471724 0.490187802471818 0.762463768115942 0.466666666666667 11.2 11 2 abnormal enteric neuron morphology 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 joint inflammation 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 arthritis 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 dilated ureter 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 decreased aggression towards males 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 abnormal Muller cell morphology 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 abnormal aorta wall morphology 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 decreased trabecular bone mass 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 impaired macrophage phagocytosis 0.159065424357713 0.381557611465583 0.759930665896288 0.465116279069767 11.2 11 2 abnormal axon guidance 0.159065424357713 0.381557611465583 0.759930665896288 0.465116279069767 11.2 11 2 abnormal CNS synaptic transmission 0.0515756054523972 0.198862688819956 0.759163059163059 0.464646464646465 11.2 11 2 abnormal jaw morphology 0.231268938152804 0.521088300412227 0.758573646850044 0.464285714285714 11.2 11 2 reddish skin 0.231268938152804 0.521088300412227 0.758573646850044 0.464285714285714 11.2 11 2 straub tail 0.231268938152804 0.521088300412227 0.758573646850044 0.464285714285714 11.2 11 2 decreased tumor growth/size 0.131426981558311 0.377387385917969 0.75641246836899 0.462962962962963 11.2 11 2 abnormal social investigation 0.07991693756633 0.25650758993064 0.755656055900621 0.4625 11.2 11 2 increased vascular permeability 0.186311856300247 0.43701154412717 0.754085045389393 0.461538461538462 11.2 11 2 increased percent body fat/body weight 0.141607457430308 0.377387385917969 0.754085045389393 0.461538461538462 11.2 11 2 abnormal xiphoid process morphology 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 increased susceptibility to otitis media 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 pulmonary edema 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 decreased Peyer's patch number 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 abnormal membranous labyrinth morphology 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 absent teeth 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 abnormal sympathetic ganglion morphology 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 lymphoid hypoplasia 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 increased synaptic depression 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 absent lateral semicircular canal 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 abnormal vestibulocochlear ganglion morphology 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 small otic vesicle 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 decreased endocochlear potential 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 increased circulating thyroid-stimulating hormone level 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 small pituitary gland 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 abnormal cytokine secretion 0.0235174651969513 0.108232552594665 0.753268936032911 0.461038961038961 11.2 11 2 abnormal immune system physiology 0.0414499688099788 0.165032564239577 0.751044379883791 0.459677419354839 11.2 11 2 impaired skeletal muscle contractility 0.201882932638799 0.471534079754942 0.750688265905657 0.459459459459459 11.2 11 2 decreased circulating chloride level 0.201882932638799 0.471534079754942 0.750688265905657 0.459459459459459 11.2 11 2 increased insulin secretion 0.201882932638799 0.471534079754942 0.750688265905657 0.459459459459459 11.2 11 2 abnormal lymph node morphology 0.164619547791217 0.394500120549761 0.7488483436853 0.458333333333333 11.2 11 2 abnormal osteoclast morphology 0.164619547791217 0.394500120549761 0.7488483436853 0.458333333333333 11.2 11 2 abnormal adrenal gland morphology 0.276285685176147 0.591674160109291 0.7488483436853 0.458333333333333 11.2 11 2 abnormal tumor morphology 0.276285685176147 0.591674160109291 0.7488483436853 0.458333333333333 11.2 11 2 increased B cell proliferation 0.135898225191436 0.377387385917969 0.74769449415728 0.457627118644068 11.2 11 2 abnormal inner ear morphology 0.177623439255482 0.420598101045228 0.745888468809074 0.456521739130435 11.2 11 2 decreased susceptibility to injury 0.121356618953278 0.369939039549948 0.744843807088053 0.455882352941176 11.2 11 2 increased neutrophil cell number 0.0376035812912238 0.160523478223868 0.743683872349539 0.455172413793103 11.2 11 2 abnormal T-helper 2 physiology 0.157174022133937 0.378070264441479 0.742659514398645 0.454545454545455 11.2 11 2 abnormal middle ear ossicle morphology 0.237702976124879 0.534858573596234 0.742659514398645 0.454545454545455 11.2 11 2 head tossing 0.237702976124879 0.534858573596234 0.742659514398645 0.454545454545455 11.2 11 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.237702976124879 0.534858573596234 0.742659514398645 0.454545454545455 11.2 11 2 abnormal temporal bone morphology 0.302909134849101 0.599070484338175 0.742659514398645 0.454545454545455 11.2 11 2 social withdrawal 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal hypothalamus secretion 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal vestibular ganglion morphology 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 retinal detachment 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 pulmonary hypertension 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal ureter development 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal hair medulla 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal pituitary gland development 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal Bruch membrane morphology 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 enhanced behavioral response to addictive substance 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 aberrant origin of the right subclavian artery 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 increased pancreatic beta cell proliferation 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 decreased embryonic cilium length 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 chylous ascites 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal cued conditioning behavior 0.182017935923347 0.430389368449929 0.736834733893557 0.450980392156863 11.2 11 2 decreased paired-pulse facilitation 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 abnormal male reproductive system physiology 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 abnormal incus morphology 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 enhanced behavioral response to xenobiotic 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 absent long term depression 0.281103386594541 0.591674160109291 0.732415934889698 0.448275862068966 11.2 11 2 increased double-positive T cell number 0.281103386594541 0.591674160109291 0.732415934889698 0.448275862068966 11.2 11 2 increased grooming behavior 0.242140662822719 0.544351467484423 0.730933311539719 0.447368421052632 11.2 11 2 hyporesponsive to tactile stimuli 0.242140662822719 0.544351467484423 0.730933311539719 0.447368421052632 11.2 11 2 enhanced long term potentiation 0.185516294481274 0.435350738228462 0.729397737355812 0.446428571428571 11.2 11 2 wrinkled skin 0.306280637801151 0.599070484338175 0.726155969634231 0.444444444444444 11.2 11 2 abnormal palate morphology 0.306280637801151 0.599070484338175 0.726155969634231 0.444444444444444 11.2 11 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.155745112070034 0.377387385917969 0.72615596963423 0.444444444444444 11.2 11 2 abnormal cartilage development 0.227455205842116 0.515295832907344 0.72615596963423 0.444444444444444 11.2 11 2 abnormal systemic arterial blood pressure 0.262072877672062 0.574619905869771 0.72615596963423 0.444444444444444 11.2 11 2 abnormal epidermis stratum granulosum morphology 0.262072877672062 0.574619905869771 0.72615596963423 0.444444444444444 11.2 11 2 impaired wound healing 0.262072877672062 0.574619905869771 0.72615596963423 0.444444444444444 11.2 11 2 absent spleen 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 decreased tumor latency 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 abnormal macrophage chemotaxis 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 impaired leukocyte tethering or rolling 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 dehydration 0.166558601356868 0.398762772738412 0.723562555456965 0.442857142857143 11.2 11 2 abnormal male reproductive system morphology 0.245188950384431 0.550209755598801 0.721934132601473 0.441860465116279 11.2 11 2 abnormal retinal photoreceptor morphology 0.283859260466936 0.592863064997064 0.720816587504567 0.441176470588235 11.2 11 2 abnormal vision 0.283859260466936 0.592863064997064 0.720816587504567 0.441176470588235 11.2 11 2 decreased regulatory T cell number 0.283859260466936 0.592863064997064 0.720816587504567 0.441176470588235 11.2 11 2 decreased inflammatory response 0.14993536374598 0.377387385917969 0.719672434191068 0.44047619047619 11.2 11 2 mandible hypoplasia 0.334206759232768 0.599070484338175 0.718894409937888 0.44 11.2 11 2 increased pre-B cell number 0.334206759232768 0.599070484338175 0.718894409937888 0.44 11.2 11 2 abnormal serotonin level 0.307705119476858 0.599070484338175 0.714809782608696 0.4375 11.2 11 2 abnormal pituitary gland morphology 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 paternal imprinting 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 decreased cochlear coiling 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 impaired muscle relaxation 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 abnormal pulmonary elastic fiber morphology 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 decreased aggression towards mice 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 abnormal molar crown morphology 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 bowed radius 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 sepsis 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 decreased circulating prolactin level 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 impaired behavioral response to addictive substance 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 abnormal response to injury 0.285281104226448 0.595582666188241 0.712191431756649 0.435897435897436 11.2 11 2 abnormal immune system morphology 0.265787333985681 0.582507483074344 0.710369970294356 0.434782608695652 11.2 11 2 abnormal B cell morphology 0.365282518079775 0.599070484338175 0.710369970294356 0.434782608695652 11.2 11 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.365282518079775 0.599070484338175 0.710369970294356 0.434782608695652 11.2 11 2 gastrointestinal hemorrhage 0.333843500394342 0.599070484338175 0.708002070393375 0.433333333333333 11.2 11 2 abnormal pain threshold 0.333843500394342 0.599070484338175 0.708002070393375 0.433333333333333 11.2 11 2 abnormal thrombosis 0.266449351689938 0.583701243794558 0.704798441115577 0.431372549019608 11.2 11 2 abnormal inflammatory response 0.219837852204791 0.507749913982745 0.703463595583161 0.430555555555556 11.2 11 2 abnormal humoral immune response 0.175048303124782 0.41469776573609 0.700221827861579 0.428571428571429 11.2 11 2 abnormal stria vascularis morphology 0.362539412537411 0.599070484338175 0.700221827861579 0.428571428571429 11.2 11 2 abnormal muscle morphology 0.307380467896899 0.599070484338175 0.700221827861579 0.428571428571429 11.2 11 2 decreased circulating progesterone level 0.362539412537411 0.599070484338175 0.700221827861579 0.428571428571429 11.2 11 2 abnormal salivary gland morphology 0.399989857890053 0.629531649162611 0.700221827861579 0.428571428571429 11.2 11 2 increased vasoconstriction 0.399989857890053 0.629531649162611 0.700221827861579 0.428571428571429 11.2 11 2 abnormal tumor vascularization 0.399989857890053 0.629531649162611 0.700221827861579 0.428571428571429 11.2 11 2 abnormal interparietal bone morphology 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal vasoconstriction 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal pinna reflex 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal vascular endothelial cell migration 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal hair cuticle 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal decidualization 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 decreased cornea thickness 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 increased lung compliance 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal excitatory postsynaptic potential 0.220486851167642 0.509012568240843 0.69737539766702 0.426829268292683 11.2 11 2 decreased T cell proliferation 0.142300553336401 0.377387385917969 0.695490599294947 0.425675675675676 11.2 11 2 abnormal stomach morphology 0.39409447408231 0.621038963750234 0.691244624940277 0.423076923076923 11.2 11 2 abnormal tectorial membrane morphology 0.39409447408231 0.621038963750234 0.691244624940277 0.423076923076923 11.2 11 2 thin dermal layer 0.438913332245789 0.670431018705189 0.687937234390324 0.421052631578947 11.2 11 2 decreased grooming behavior 0.438913332245789 0.670431018705189 0.687937234390324 0.421052631578947 11.2 11 2 altered susceptibility to infection 0.438913332245789 0.670431018705189 0.687937234390324 0.421052631578947 11.2 11 2 abnormal food intake 0.281621158738638 0.591674160109291 0.686690971284544 0.420289855072464 11.2 11 2 abnormal T cell proliferation 0.388374605844099 0.612413205728809 0.685163293929072 0.419354838709677 11.2 11 2 increased susceptibility to pharmacologically induced seizures 0.258722802216458 0.568025569738252 0.680771221532091 0.416666666666667 11.2 11 2 abnormal hair shaft morphology 0.348496307073018 0.599070484338175 0.680771221532091 0.416666666666667 11.2 11 2 abnormal reflex 0.382871166556987 0.60392645961351 0.680771221532091 0.416666666666667 11.2 11 2 abnormal malleus morphology 0.42885168443951 0.655867546906413 0.680771221532091 0.416666666666667 11.2 11 2 increased stereotypic behavior 0.42885168443951 0.655867546906413 0.680771221532091 0.416666666666667 11.2 11 2 abnormal adipose tissue distribution 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal supraoccipital bone morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal esophagus morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal tracheal ciliated epithelium morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 increased growth rate 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal AMPA-mediated synaptic currents 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 small thyroid gland 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 absent tail 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 impaired sperm capacitation 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 bowed ulna 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased cochlear nerve compound action potential 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 increased placenta weight 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal anogenital distance 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal patella morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal somatic nervous system physiology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased keratinocyte proliferation 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal behavioral response to addictive substance 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 persistent right dorsal aorta 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased compensatory feeding amount 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased monocyte cell number 0.317922626836595 0.599070484338175 0.678676540850454 0.415384615384615 11.2 11 2 arrested B cell differentiation 0.377587584533457 0.599070484338175 0.677450386305105 0.414634146341463 11.2 11 2 increased tumor growth/size 0.377587584533457 0.599070484338175 0.677450386305105 0.414634146341463 11.2 11 2 delayed wound healing 0.372514173350127 0.599070484338175 0.674851471779638 0.41304347826087 11.2 11 2 abnormal lymphocyte physiology 0.372514173350127 0.599070484338175 0.674851471779638 0.41304347826087 11.2 11 2 lung hemorrhage 0.412084116140492 0.633299809210644 0.672762148337596 0.411764705882353 11.2 11 2 increased susceptibility to viral infection induced morbidity/mortality 0.412084116140492 0.633299809210644 0.672762148337596 0.411764705882353 11.2 11 2 distended urinary bladder 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 enlarged sebaceous gland 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 decreased vasoconstriction 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 pancytopenia 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 decreased macrophage cell number 0.398100856713381 0.62715381955322 0.66839356295878 0.409090909090909 11.2 11 2 abnormal basisphenoid bone morphology 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 intestinal ulcer 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 increased coping response 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 impaired humoral immune response 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 increased dopamine level 0.443569517569054 0.677335282352991 0.663751940993789 0.40625 11.2 11 2 abnormal T cell activation 0.365075368551311 0.599070484338175 0.662371999328521 0.405405405405405 11.2 11 2 abnormal nervous system electrophysiology 0.355919852721723 0.599070484338175 0.661320615202603 0.404761904761905 11.2 11 2 increased systemic arterial blood pressure 0.417442700160119 0.638811883511717 0.66049292982688 0.404255319148936 11.2 11 2 abnormal hearing physiology 0.509574152258473 0.735033751083185 0.653540372670807 0.4 11.2 11 2 nuclear cataracts 0.509574152258473 0.735033751083185 0.653540372670807 0.4 11.2 11 2 abnormal digestive system physiology 0.435720968307591 0.666168351976111 0.653540372670807 0.4 11.2 11 2 arrested T cell differentiation 0.477477109977343 0.710268388834351 0.653540372670807 0.4 11.2 11 2 abnormal spleen marginal zone morphology 0.477477109977343 0.710268388834351 0.653540372670807 0.4 11.2 11 2 decreased chondrocyte number 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 hyperpigmentation 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 increased airway responsiveness 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal bronchus morphology 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal rostral migratory stream morphology 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal microglial cell activation 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal excitatory postsynaptic currents 0.414647887984797 0.634730228530574 0.649351011307533 0.397435897435897 11.2 11 2 abnormal intestinal mucosa morphology 0.473170388338144 0.710268388834351 0.645941066011845 0.395348837209302 11.2 11 2 decreased threshold for auditory brainstem response 0.484957059619067 0.710268388834351 0.644941157240928 0.394736842105263 11.2 11 2 abnormal NK cell physiology 0.460093995779313 0.700632883073793 0.642826596069647 0.39344262295082 11.2 11 2 increased circulating luteinizing hormone level 0.513948710870909 0.740699547098137 0.641870008873114 0.392857142857143 11.2 11 2 abnormal respiration 0.513948710870909 0.740699547098137 0.641870008873114 0.392857142857143 11.2 11 2 abnormal spleen germinal center morphology 0.513948710870909 0.740699547098137 0.641870008873114 0.392857142857143 11.2 11 2 abnormal innervation pattern to muscle 0.532717706391589 0.759609074170285 0.63933297326492 0.391304347826087 11.2 11 2 abnormal cochlear ganglion morphology 0.532717706391589 0.759609074170285 0.63933297326492 0.391304347826087 11.2 11 2 lowered ear position 0.55645458026944 0.788482351706199 0.635386473429952 0.388888888888889 11.2 11 2 abnormal stomach glandular epithelium morphology 0.55645458026944 0.788482351706199 0.635386473429952 0.388888888888889 11.2 11 2 abnormal sperm axoneme morphology 0.55645458026944 0.788482351706199 0.635386473429952 0.388888888888889 11.2 11 2 abnormal CD8-positive, alpha beta T cell morphology 0.533752375745708 0.759609074170285 0.632458425165297 0.387096774193548 11.2 11 2 abnormal leukocyte adhesion 0.535040981605488 0.759609074170285 0.628404204491161 0.384615384615385 11.2 11 2 abnormal leukocyte migration 0.52307384438523 0.753632312718366 0.628404204491161 0.384615384615385 11.2 11 2 abnormal renal/urinary system morphology 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 small trigeminal ganglion 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 dystrophic cardiac calcinosis 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 abnormal GABAergic neuron morphology 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 muscle fatigue 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 vestibular hair cell degeneration 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 hyperalgesia 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 abnormal hair follicle inner root sheath morphology 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 decreased cardiac stroke volume 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 thin skin 0.551759221224859 0.782720879838516 0.624707709170625 0.382352941176471 11.2 11 2 abnormal bone remodeling 0.551759221224859 0.782720879838516 0.624707709170625 0.382352941176471 11.2 11 2 increased acute inflammation 0.577010641100578 0.800371825313034 0.622419402543626 0.380952380952381 11.2 11 2 decreased vocalization 0.577010641100578 0.800371825313034 0.622419402543626 0.380952380952381 11.2 11 2 increased susceptibility to parasitic infection 0.554541293209323 0.786443253624967 0.617232574189096 0.377777777777778 11.2 11 2 abnormal crypts of Lieberkuhn morphology 0.5878620906517 0.800371825313034 0.612694099378882 0.375 11.2 11 2 head bobbing 0.583508206119023 0.800371825313034 0.612694099378882 0.375 11.2 11 2 abnormal sensory capabilities/reflexes/nociception 0.595037319562836 0.800371825313034 0.612694099378882 0.375 11.2 11 2 small lymph nodes 0.595037319562836 0.800371825313034 0.612694099378882 0.375 11.2 11 2 decreased susceptibility to parasitic infection 0.5878620906517 0.800371825313034 0.612694099378882 0.375 11.2 11 2 decreased circulating growth hormone level 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 increased circulating estradiol level 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 abnormal pancreatic alpha cell morphology 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 abnormal cellular extravasation 0.595037319562836 0.800371825313034 0.612694099378882 0.375 11.2 11 2 dilated respiratory conducting tubes 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 enlarged adrenal glands 0.625020308283236 0.803193832030618 0.601945080091533 0.368421052631579 11.2 11 2 abnormal response to novelty 0.625020308283236 0.803193832030618 0.601945080091533 0.368421052631579 11.2 11 2 impaired natural killer cell mediated cytotoxicity 0.61842694460815 0.803193832030618 0.601945080091533 0.368421052631579 11.2 11 2 decreased IgA level 0.63487583327209 0.813000584434658 0.596983994266603 0.365384615384615 11.2 11 2 decreased airway responsiveness 0.639759813600282 0.814855810147679 0.594127611518916 0.363636363636364 11.2 11 2 impaired conditioned place preference behavior 0.653024892367179 0.828802788064003 0.588186335403727 0.36 11.2 11 2 abnormal zigzag hair morphology 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 increased aggression towards males 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal olfactory system physiology 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal endplate potential 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 decreased coping response 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal prepulse inhibition 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal imprinting 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal positive T cell selection 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal tendon morphology 0.676841384372582 0.855944557003964 0.576653270003654 0.352941176470588 11.2 11 2 decreased susceptibility to induced arthritis 0.718042043636085 0.907586170500387 0.573281028658603 0.350877192982456 11.2 11 2 brain inflammation 0.6871836230658 0.868802674651171 0.571847826086957 0.35 11.2 11 2 abnormal diaphragm morphology 0.722564845066607 0.908338324296513 0.561636257763975 0.34375 11.2 11 2 abnormal action potential 0.774573341729455 0.928554789181696 0.560177462289263 0.342857142857143 11.2 11 2 abnormal inhibitory postsynaptic currents 0.795712893575509 0.950689636296388 0.552626050420168 0.338235294117647 11.2 11 2 eye inflammation 0.737034786424153 0.911899543014215 0.544616977225673 0.333333333333333 11.2 11 2 increased susceptibility to autoimmune disorder 0.737034786424153 0.911899543014215 0.544616977225673 0.333333333333333 11.2 11 2 decreased salivation 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 increased alcohol consumption 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 greasy coat 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 abnormal neurotransmitter secretion 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 lactation failure 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 hypoalgesia 0.742270114048412 0.912870785642529 0.544616977225673 0.333333333333333 11.2 11 2 decreased cytotoxic T cell cytolysis 0.801523377010441 0.955108694760945 0.528598830836683 0.323529411764706 11.2 11 2 abnormal body temperature homeostasis 0.798202024715769 0.951378790838752 0.527048687637748 0.32258064516129 11.2 11 2 decreased acute inflammation 0.792333501218327 0.946879454374532 0.522832298136646 0.32 11.2 11 2 increased activated T cell number 0.790108254257539 0.945619731482724 0.519861660079051 0.318181818181818 11.2 11 2 abnormal nail morphology 0.788733776335345 0.944626803825839 0.515952925792743 0.315789473684211 11.2 11 2 bowed tibia 0.788739646852771 0.944626803825839 0.510578416149068 0.3125 11.2 11 2 abnormal wound healing 0.788739646852771 0.944626803825839 0.510578416149068 0.3125 11.2 11 2 abnormal fertilization 0.788739646852771 0.944626803825839 0.510578416149068 0.3125 11.2 11 2 increased susceptibility to induced arthritis 0.831376074318586 0.985488675181074 0.507057185692868 0.310344827586207 11.2 11 2 increased susceptibility to age related obesity 0.83090920536306 0.985169994442618 0.497258979206049 0.304347826086957 11.2 11 2 increased susceptibility to fungal infection 0.83090920536306 0.985169994442618 0.497258979206049 0.304347826086957 11.2 11 2 abnormal thymocyte activation 0.832255270593721 0.986295848309614 0.490155279503106 0.3 11.2 11 2 abnormal estrous cycle 0.862451761680064 1 0.490155279503106 0.3 11.2 11 2 abnormal synaptic transmission 0.862451761680064 1 0.490155279503106 0.3 11.2 11 2 increased aggression towards mice 0.835363922886182 0.988894347612323 0.480544391669711 0.294117647058824 11.2 11 2 decreased growth hormone level 0.835363922886182 0.988894347612323 0.480544391669711 0.294117647058824 11.2 11 2 abnormal stomach mucosa morphology 0.893466522729778 1 0.457478260869565 0.28 11.2 11 2 blepharoptosis 0.873182821525425 1 0.453847481021394 0.277777777777778 11.2 11 2 abnormal retinal cone cell morphology 0.921073308098527 1 0.426221982176614 0.260869565217391 11.2 11 2 abnormal regulatory T cell physiology 0.921073308098527 1 0.426221982176614 0.260869565217391 11.2 11 2 abnormal single cell response 0.935211182456367 1 0.423590982286634 0.259259259259259 11.2 11 2 abnormal channel response 0.959487097982231 1 0.371329757199322 0.227272727272727 11.2 11 2 embryonic lethality between implantation and placentation, incomplete penetrance 5.72415429142659e-06 0.000114829304838094 1.73360193392425 1 11.3 11 3 decreased cardiomyocyte apoptosis 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 abnormal thyroid hormone level 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 abnormal renal filtration rate 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 abnormal retina inner limiting membrane morphology 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 ductus venosus stenosis 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 thin tail 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 abnormal lacrimal gland physiology 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 absent ectoplacental cone 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 abnormal hippocampal fimbria morphology 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 bile duct inflammation 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 increased triiodothyronine level 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 aminoaciduria 3.73663096234353e-08 1.27326979709994e-06 1.73360193392425 1 11.3 11 3 abnormal plasma membrane morphology 4.28201527273883e-05 0.000643595951114068 1.73360193392425 1 11.3 11 3 abnormal kidney epithelium morphology 0.000320255226042277 0.00367960681191761 1.73360193392425 1 11.3 11 3 abnormal cerebellum deep nucleus morphology 0.000320255226042277 0.00367960681191761 1.73360193392425 1 11.3 11 3 abnormal tooth eruption 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 absent lungs 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased urine microalbumin level 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased lysosomal enzyme secretion 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 bile duct proliferation 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 gastric polyps 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 premature endochondral bone ossification 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased heart right ventricle weight 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 hemolysis 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased response to stress-induced hyperthermia 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 leptocytosis 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 aorta hypoplasia 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 enlarged aortic valve 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 abnormal paranode morphology 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 pale lung 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 abnormal lung alveolus development 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 cystinuria 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased liver adenoma incidence 1.69642939255719e-07 4.87846024738266e-06 1.64235972687561 0.947368421052632 11.3 11 3 testis degeneration 1.93524218723591e-05 0.000329720201421186 1.60977322435824 0.928571428571429 11.3 11 3 multiple persisting craniopharyngeal ducts 1.93524218723591e-05 0.000329720201421186 1.60977322435824 0.928571428571429 11.3 11 3 decreased red blood cell distribution width 0.00012491065845378 0.00164399610001999 1.58913510609723 0.916666666666667 11.3 11 3 abnormal thrombopoiesis 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 delayed hepatic development 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 abnormal eye distance/ position 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 fatigue 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 pharyngeal arch hypoplasia 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 common atrioventricular valve 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 reduced sympathetic cervical ganglion size 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 absent ductus venosus valve 1.1098970418515e-06 2.69353062595668e-05 1.56024174053183 0.9 11.3 11 3 abnormal mammary gland physiology 0.000785689893697496 0.00778646856801801 1.56024174053183 0.9 11.3 11 3 decreased transitional stage T2 B cell number 0.000785689893697496 0.00778646856801801 1.56024174053183 0.9 11.3 11 3 abnormal inferior vena cava valve morphology 0.000785689893697496 0.00778646856801801 1.56024174053183 0.9 11.3 11 3 decreased cellular sensitivity to gamma-irradiation 6.73682704203645e-06 0.000131434174643652 1.54097949682156 0.888888888888889 11.3 11 3 dilated uterus 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 pancreas cysts 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 liver hyperplasia 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 positive geotaxis 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 decreased transitional stage T1 B cell number 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 abnormal infrahyoid muscle connection 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 impaired somite development 3.98939292819083e-05 0.000612568821535474 1.51690169218372 0.875 11.3 11 3 early eyelid opening 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 colon polyps 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 liver cysts 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 elevated level of mitotic sister chromatid exchange 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 binucleate 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 abnormal extraembryonic tissue physiology 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 ocular hypertension 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 craniofacial phenotype 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 stomach epithelial hyperplasia 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 abnormal pulmonary acinus morphology 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 abnormal foramen magnum morphology 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 increased circulating ferritin level 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 increased circulating lactate level 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 increased brain apoptosis 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 decreased basal metabolism 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 subcutaneous edema 1.18657146171194e-07 3.55614037470898e-06 1.48594451479222 0.857142857142857 11.3 11 3 abnormal blood flow velocity 0.000228995662740816 0.00280073683403888 1.48594451479222 0.857142857142857 11.3 11 3 irregularly shaped pupil 0.000228995662740816 0.00280073683403888 1.48594451479222 0.857142857142857 11.3 11 3 failure of atrioventricular cushion closure 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 skin photosensitivity 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal lacrimal gland morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal axial mesoderm 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal gastrulation movements 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal brain ventricular system morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased mortality induced by ionizing radiation 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal talus morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 urolithiasis 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased tidal volume 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 uremia 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 arteritis 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased brain cholesterol level 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal conotruncal ridge morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 increased compact bone volume 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 impaired branching involved in bronchus morphogenesis 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased CD8-positive, naive alpha-beta T cell number 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased circulating fructosamine level 2.79431118991102e-07 7.68049622641289e-06 1.47677201778733 0.851851851851852 11.3 11 3 abnormal Mullerian duct morphology 6.54179600806115e-07 1.6689966738515e-05 1.46689394408975 0.846153846153846 11.3 11 3 tracheoesophageal fistula 0.000540761270397811 0.00572948788917116 1.46689394408975 0.846153846153846 11.3 11 3 increased fibroblast apoptosis 3.65572617477336e-08 1.2569797035825e-06 1.46272663174859 0.84375 11.3 11 3 embryonic lethality between implantation and somite formation, incomplete penetrance 2.80425306864602e-05 0.000451493819304658 1.45987531277832 0.842105263157895 11.3 11 3 absent inner cell mass 6.50176812387148e-05 0.000943040711844333 1.44466827827021 0.833333333333333 11.3 11 3 dilated bile duct 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 absent ovary 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 pale placenta 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 abnormal pulmonary valve cusp morphology 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 echinocytosis 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 delayed brain development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal parental behavior 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal hepatobiliary system physiology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 liver cirrhosis 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 loss of hippocampal neurons 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 esophageal atresia 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 enlarged pancreas 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal leukocyte tethering or rolling 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal heart left atrium morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 absent parietal bone 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 decreased prostate gland weight 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal blastocoele morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal eyelid development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 absent sperm mitochondrial sheath 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal olfactory bulb layer morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 increased erythrocyte clearance 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 myocardium hypoplasia 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal intestinal enteroendocrine cell morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 delayed limb development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal Rathke's pouch development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 ciliary body hypoplasia 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 additional anastomosis between intracranial vertebral arteries 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal platelet alpha-granule morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 decreased capillary density 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 increased cardiac cell glucose uptake 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 blood in lymph vessels 4.47676509145972e-07 1.16606839424147e-05 1.4347050487649 0.827586206896552 11.3 11 3 abnormal Wolffian duct morphology 8.06182746428246e-06 0.000150780419679719 1.43210594541569 0.826086956521739 11.3 11 3 abnormal interatrial septum morphology 0.000149297519803894 0.00189962956783726 1.4276721808788 0.823529411764706 11.3 11 3 abnormal head morphology 7.50866879369987e-12 4.6694534060821e-10 1.41840158230166 0.818181818181818 11.3 11 3 embryonic lethality before implantation, incomplete penetrance 1.83356218193873e-05 0.000316735133859208 1.41840158230166 0.818181818181818 11.3 11 3 premature suture closure 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 loss of cortex neurons 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal dorsal-ventral polarity of the somites 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal palate development 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 palatal shelf hypoplasia 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal brain ependyma motile cilium morphology 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal eye muscle morphology 2.30307292079217e-06 5.04748360393878e-05 1.4125645387531 0.814814814814815 11.3 11 3 absent mandible 0.000339132208496192 0.00386968517722145 1.40855157131346 0.8125 11.3 11 3 liver degeneration 4.13304178995855e-05 0.000623800795511133 1.40339204174821 0.80952380952381 11.3 11 3 liver fibrosis 1.09344410163352e-08 4.12112454971723e-07 1.39533814193903 0.804878048780488 11.3 11 3 embryonic lethality between implantation and placentation, complete penetrance 1.42638382945347e-09 6.06517910387265e-08 1.39441894685212 0.804347826086957 11.3 11 3 liver hemorrhage 1.45681968104209e-06 3.40384444454383e-05 1.3868815471394 0.8 11.3 11 3 vagina atresia 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 abnormal placenta size 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 immune system phenotype 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 heterochrony 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 increased mammary adenocarcinoma incidence 9.22501168154142e-05 0.00125394625999094 1.3868815471394 0.8 11.3 11 3 increased skin tumor incidence 9.22501168154142e-05 0.00125394625999094 1.3868815471394 0.8 11.3 11 3 fused cornea and lens 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 decreased incidence of induced tumors 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal respiratory mechanics 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 ketoaciduria 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 impaired basement membrane formation 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 acrania 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 bifid ureter 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 absent seminal vesicle 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal hindlimb zeugopod morphology 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 vascular smooth muscle hyperplasia 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 crystalluria 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal spinal cord dorsal column morphology 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal hippocampus neuron morphology 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 acanthocytosis 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 fusion of atlas and odontoid process 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal adaptive thermogenesis 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 lethality during fetal growth through weaning, complete penetrance 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal amino acid level 6.93796614469278e-09 2.71782532046036e-07 1.37900153834884 0.795454545454545 11.3 11 3 increased hepatocyte apoptosis 5.32512911305096e-08 1.73153708087768e-06 1.37799128081159 0.794871794871795 11.3 11 3 abnormal blastocyst morphology 0.00020367449580967 0.00254315620150318 1.36863310572967 0.789473684210526 11.3 11 3 decreased liver regeneration 0.00020367449580967 0.00254315620150318 1.36863310572967 0.789473684210526 11.3 11 3 embryonic lethality between somite formation and embryo turning, complete penetrance 8.30257823893475e-13 6.16497414010454e-11 1.3621158052262 0.785714285714286 11.3 11 3 lymphoid hyperplasia 7.01137185250027e-06 0.000135199902969724 1.3621158052262 0.785714285714286 11.3 11 3 premature aging 7.01137185250027e-06 0.000135199902969724 1.3621158052262 0.785714285714286 11.3 11 3 abnormal maternal decidual layer morphology 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 split sternum 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 abnormal renal tubule epithelial cell primary cilium morphology 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 abnormal vitelline vein topology 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 failure to gastrulate 9.37372751014298e-09 3.58725341253549e-07 1.35673194828855 0.782608695652174 11.3 11 3 increased embryonic tissue cell apoptosis 6.90493010962945e-14 6.60615909527048e-12 1.35576561499205 0.782051282051282 11.3 11 3 abnormal bile duct morphology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal body wall morphology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal anterior eye segment morphology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal aerobic respiration 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal hypoglossal nerve topology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal ion homeostasis 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 short frontal bone 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 eye opacity 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 abnormal pulmonary alveolar system morphology 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 trigeminal neuroma 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 symmetric azygos veins 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 decreased fatty acid oxidation 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 cerebellum atrophy 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 increased endoplasmic reticulum stress 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 abnormal mesoderm development 1.62361081102076e-09 6.84530829222734e-08 1.34108828850744 0.773584905660377 11.3 11 3 abnormal germ layer development 0.00011951272457226 0.00159403701004556 1.33960149439601 0.772727272727273 11.3 11 3 kidney cysts 1.44279302268651e-12 1.04027467940078e-10 1.3353420301849 0.77027027027027 11.3 11 3 liver hypoplasia 3.45503408225673e-09 1.3974629722949e-07 1.3335399491725 0.769230769230769 11.3 11 3 decreased circulating glycerol level 3.25781950073213e-05 0.00051290038025767 1.3335399491725 0.769230769230769 11.3 11 3 increased circulating thyroxine level 0.00366697413958651 0.0278097505250654 1.3335399491725 0.769230769230769 11.3 11 3 absent hypoglossal nerve 0.00366697413958651 0.0278097505250654 1.3335399491725 0.769230769230769 11.3 11 3 abnormal gastrulation 7.3123162523012e-09 2.84209166837488e-07 1.32569559653031 0.764705882352941 11.3 11 3 abnormal testis development 0.000956094946746163 0.0090947846272699 1.32569559653031 0.764705882352941 11.3 11 3 abnormal ductus venosus valve morphology 0.000956094946746163 0.0090947846272699 1.32569559653031 0.764705882352941 11.3 11 3 abnormal erythropoiesis 1.38633345042035e-16 1.97057397595464e-14 1.32083956870419 0.761904761904762 11.3 11 3 abnormal embryonic/fetal subventricular zone morphology 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 vascular ring 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 embryonic lethality at implantation, complete penetrance 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 absent segment of posterior cerebral artery 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 increased muscle cell glucose uptake 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 corneal opacity 1.35402719304259e-11 8.01938724450817e-10 1.31851414692831 0.76056338028169 11.3 11 3 abnormal egg cylinder morphology 6.91795916047482e-05 0.000997589762996007 1.31753746978243 0.76 11.3 11 3 increased mortality induced by gamma-irradiation 1.89615834908268e-05 0.000325289234023666 1.31514629470116 0.758620689655172 11.3 11 3 malocclusion 1.45732435515143e-06 3.40384444454383e-05 1.31191497702376 0.756756756756757 11.3 11 3 anophthalmia 1.11788649837167e-13 1.01117915079983e-11 1.30507111879691 0.752808988764045 11.3 11 3 abnormal mineral level 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 amyloidosis 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 interstitial pneumonia 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 abnormal embryonic growth/weight/body size 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 increased osteosarcoma incidence 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 delayed somite formation 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 decreased left ventricle systolic pressure 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 abnormal rostral-caudal body axis extension 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 increased hepatocyte proliferation 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 hemoperitoneum 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 prenatal growth retardation 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 abnormal vitelline vein connection 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 decreased mean corpuscular hemoglobin 1.22281208570201e-10 6.27163930553351e-09 1.30020145044319 0.75 11.3 11 3 abnormal brainstem morphology 3.97068576619049e-05 0.000611583953151631 1.30020145044319 0.75 11.3 11 3 increased triglyceride level 3.97068576619049e-05 0.000611583953151631 1.30020145044319 0.75 11.3 11 3 anencephaly 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 abnormal optic stalk morphology 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 dilated vasculature 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 abnormal neuron proliferation 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 decreased creatinine clearance 0.00202649892317437 0.01720449171125 1.30020145044319 0.75 11.3 11 3 increased heart left ventricle size 0.00202649892317437 0.01720449171125 1.30020145044319 0.75 11.3 11 3 decreased midbrain size 0.00202649892317437 0.01720449171125 1.30020145044319 0.75 11.3 11 3 failure of vascular branching 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal esophageal epithelium morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal cecum morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 clubfoot 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 enlarged pituitary gland 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal pupil morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal urination 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal atrial thrombosis 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal hepatobiliary system morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal secondary sex determination 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal pulmonary circulation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 coarse hair 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal thyroid physiology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 hypospadia 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal cellular cholesterol metabolism 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 calcified muscle 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal platelet shape 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal forelimb zeugopod morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 lymph node inflammation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 tau protein deposits 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 absent interparietal bone 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal choroid pigmentation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 Sertoli cell hypoplasia 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal base-excision repair 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal sphingomyelin level 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal olfactory bulb mitral cell layer morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 increased caudal vertebrae number 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal lateral plate mesoderm morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 decreased quadriceps weight 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 pleural effusion 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 heart right ventricle hypoplasia 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal hepatic vein morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 anomalous pulmonary venous connection 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 increased heart right ventricle size 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal stomach position or orientation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 lung situs inversus 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 decreased alveolar lamellar body number 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal bronchiole epithelium morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal macrophage activation involved in immune response 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 absent Reichert's membrane 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 decreased cranium length 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 increased cornea thickness 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal umbilical vein topology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 embryo cyst 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal placenta morphology 5.84604988979245e-12 3.82685502654177e-10 1.29471536837381 0.746835443037975 11.3 11 3 decreased circulating total protein level 1.10273289312315e-08 4.12488431826142e-07 1.29232144165263 0.745454545454545 11.3 11 3 small lung 3.89945953371499e-08 1.31079805271838e-06 1.29170340174748 0.745098039215686 11.3 11 3 decreased embryo size 1.27380312225776e-64 2.11239017774412e-61 1.29113449472183 0.744769874476987 11.3 11 3 abnormal developmental patterning 3.4312228656442e-12 2.27604450087732e-10 1.28963070694365 0.74390243902439 11.3 11 3 increased circulating serum albumin level 6.28832810550147e-06 0.000123726042625805 1.28781857948659 0.742857142857143 11.3 11 3 decreased triglyceride level 6.28832810550147e-06 0.000123726042625805 1.28781857948659 0.742857142857143 11.3 11 3 pale kidney 2.26658011782473e-05 0.000374625783593955 1.28622078968574 0.741935483870968 11.3 11 3 abnormal heart valve morphology 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal atrioventricular cushion morphology 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal type II pneumocyte morphology 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal fetal cardiomyocyte proliferation 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal urine homeostasis 9.63033016234395e-14 8.87238751067799e-12 1.28214309696481 0.739583333333333 11.3 11 3 abnormal pulmonary artery morphology 0.000301388479949996 0.00353633888620573 1.28135795116141 0.739130434782609 11.3 11 3 abnormal sacral vertebrae morphology 0.000301388479949996 0.00353633888620573 1.28135795116141 0.739130434782609 11.3 11 3 abnormal vertebral artery topology 0.000301388479949996 0.00353633888620573 1.28135795116141 0.739130434782609 11.3 11 3 decreased hair follicle number 3.59726137788878e-06 7.55121322995641e-05 1.27739089868103 0.736842105263158 11.3 11 3 persistence of hyaloid vascular system 3.59726137788878e-06 7.55121322995641e-05 1.27739089868103 0.736842105263158 11.3 11 3 enlarged liver sinusoidal spaces 1.28910168246754e-05 0.000226617698596325 1.27470730435607 0.735294117647059 11.3 11 3 decreased hepatocyte number 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 abnormal trophectoderm morphology 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 decreased thymocyte apoptosis 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 abnormal branching involved in lung morphogenesis 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 Leydig cell hyperplasia 2.05196206435365e-06 4.68280333493551e-05 1.26848921994458 0.731707317073171 11.3 11 3 distended pericardium 9.35800551828052e-08 2.87383194157072e-06 1.26686295171388 0.730769230769231 11.3 11 3 increased thymocyte apoptosis 0.000168526239512048 0.00213337924064234 1.26686295171388 0.730769230769231 11.3 11 3 pale liver 2.04743454185875e-10 1.00851354908389e-08 1.26506087070148 0.72972972972973 11.3 11 3 abnormal lung development 9.719019461903e-12 5.9693977559219e-10 1.26450964592122 0.729411764705882 11.3 11 3 enlarged pericardium 2.61748192612972e-05 0.000425554659558673 1.26080140649037 0.727272727272727 11.3 11 3 intracerebral hemorrhage 0.000617007630076213 0.00640837778628218 1.26080140649037 0.727272727272727 11.3 11 3 abnormal circulating lipid level 0.000617007630076213 0.00640837778628218 1.26080140649037 0.727272727272727 11.3 11 3 abnormal cerebral cortex pyramidal cell morphology 0.000617007630076213 0.00640837778628218 1.26080140649037 0.727272727272727 11.3 11 3 abnormal stomach epithelium morphology 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 failure of somite differentiation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal proximal-distal axis patterning 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 vasculitis 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal primary sex determination 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 impaired luteinization 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal radial glial cell morphology 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal coronal suture morphology 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 increased glycogen level 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal palatal shelf elevation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 increased number of Howell-Jolly bodies 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 aorta dilation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 hypolactation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 thin hypoglossal nerve 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 microphthalmia 1.39718972816051e-19 2.574451443555e-17 1.25771120696466 0.725490196078431 11.3 11 3 abnormal trophoblast layer morphology 1.88430728962939e-07 5.35681643766069e-06 1.25771120696466 0.725490196078431 11.3 11 3 abnormal spinal nerve morphology 9.41632023609847e-05 0.00126954453047669 1.25536691766929 0.724137931034483 11.3 11 3 abnormal embryonic erythropoiesis 9.41632023609847e-05 0.00126954453047669 1.25536691766929 0.724137931034483 11.3 11 3 polychromatophilia 9.41632023609847e-05 0.00126954453047669 1.25536691766929 0.724137931034483 11.3 11 3 oxidative stress 6.45183869358954e-12 4.11511506418051e-10 1.25204584116752 0.722222222222222 11.3 11 3 abnormal trophoblast giant cell morphology 1.4733842852304e-05 0.000257196028737588 1.25204584116752 0.722222222222222 11.3 11 3 abnormal mitral valve morphology 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 right pulmonary isomerism 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal metacarpal bone morphology 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal redox activity 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal eye anterior chamber morphology 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal glycogen homeostasis 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased adipocyte glucose uptake 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased circulating creatinine level 2.2369738137528e-11 1.25044322735058e-09 1.24980604538725 0.720930232558139 11.3 11 3 kidney failure 2.34300323311466e-06 5.11247415997607e-05 1.24980604538725 0.720930232558139 11.3 11 3 abnormal primitive streak morphology 0.000340947830582281 0.00387263803001563 1.24819339242546 0.72 11.3 11 3 abnormal preimplantation embryo development 0.000340947830582281 0.00387263803001563 1.24819339242546 0.72 11.3 11 3 decreased brain weight 6.10967471542438e-08 1.94843793007925e-06 1.24697682966481 0.719298245614035 11.3 11 3 abnormal circulating amino acid level 6.10967471542438e-08 1.94843793007925e-06 1.24697682966481 0.719298245614035 11.3 11 3 kidney cortex cysts 5.26073019009892e-05 0.000778932520706611 1.24602639000806 0.71875 11.3 11 3 increased fatty acid level 5.26073019009892e-05 0.000778932520706611 1.24602639000806 0.71875 11.3 11 3 pancreatic islet hyperplasia 5.26073019009892e-05 0.000778932520706611 1.24602639000806 0.71875 11.3 11 3 embryonic lethality between implantation and somite formation, complete penetrance 2.50135711257062e-29 1.24442516350388e-26 1.2453630219211 0.718367346938775 11.3 11 3 abnormal iris morphology 8.2885359133738e-06 0.000154439948198632 1.24463728589434 0.717948717948718 11.3 11 3 atrioventricular septal defect 2.13692132232567e-07 6.00631840597187e-06 1.24295987715324 0.716981132075472 11.3 11 3 absent mesoderm 3.47369007328079e-08 1.21701465595577e-06 1.24241471931238 0.716666666666667 11.3 11 3 decreased hemoglobin content 2.59166267053854e-17 4.02922555810289e-15 1.24179996685354 0.716312056737589 11.3 11 3 decreased glycogen level 2.93977386226099e-05 0.000471786289185433 1.23828709566018 0.714285714285714 11.3 11 3 small superior cervical ganglion 0.000188686055395562 0.00237048769089122 1.23828709566018 0.714285714285714 11.3 11 3 abnormal somite shape 0.000188686055395562 0.00237048769089122 1.23828709566018 0.714285714285714 11.3 11 3 abnormal scapula morphology 0.00124483383140837 0.0114262883971524 1.23828709566018 0.714285714285714 11.3 11 3 abnormal salivary gland morphology 0.00124483383140837 0.0114262883971524 1.23828709566018 0.714285714285714 11.3 11 3 abnormal hematopoietic system physiology 0.00124483383140837 0.0114262883971524 1.23828709566018 0.714285714285714 11.3 11 3 midline facial cleft 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 abnormal kidney blood vessel morphology 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 abnormal fluid regulation 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 increased hemangioma incidence 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 absent olfactory bulb 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 lysosomal protein accumulation 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 increased pulmonary respiratory rate 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 abnormal renal reabsorbtion 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 asymmetric rib joints 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 broad head 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal foot pad morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 mammary gland hyperplasia 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal oculomotor nerve morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal circulating free fatty acids level 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased activated T cell number 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal tumor incidence 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 detached tectorial membrane 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased cholesterol efflux 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 aorta coarctation 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 increased ectoderm apoptosis 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 renal necrosis 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal vestibular saccular macula morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal strial marginal cell morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal cochlear nerve compound action potential 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal ciliary body morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 increased thyroid-stimulating hormone level 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal renal/urinary system physiology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 retinal pigment epithelium atrophy 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal spinal cord central canal morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal sperm annulus morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased DN2 thymocyte number 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 focal dorsal hair loss 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased skeletal muscle glycogen level 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal aortic valve cusp morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 thick mitral valve cusps 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 embryonic lethality at implantation, incomplete penetrance 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 small tail bud 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 impaired mammary gland growth during pregnancy 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 absent heart tube 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 absent connection between subcutaneous lymph vessels and lymph sac 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 embryo tumor 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased cell proliferation 6.34141811207215e-22 1.43402523216177e-19 1.23694840690812 0.713513513513514 11.3 11 3 abnormal fertility/fecundity 1.83862342253602e-09 7.68668195556026e-08 1.23489452827481 0.712328767123288 11.3 11 3 abnormal hepatocyte morphology 1.30330592077636e-13 1.13753455366007e-11 1.23382479981996 0.711711711711712 11.3 11 3 eyelids open at birth 4.22395724287265e-07 1.10600985701534e-05 1.23352445298457 0.711538461538462 11.3 11 3 kinked neural tube 4.22395724287265e-07 1.10600985701534e-05 1.23352445298457 0.711538461538462 11.3 11 3 abnormal ectoderm development 2.62107930030832e-06 5.64496515975494e-05 1.23278359745725 0.711111111111111 11.3 11 3 abnormal myocardial trabeculae morphology 2.62107930030832e-06 5.64496515975494e-05 1.23278359745725 0.711111111111111 11.3 11 3 pale yolk sac 1.72393299460304e-10 8.66319863449505e-09 1.2323194470064 0.710843373493976 11.3 11 3 decreased birth body size 7.4434957323063e-14 6.98705495626865e-12 1.23176979515671 0.710526315789474 11.3 11 3 increased circulating alkaline phosphatase level 5.23949775563206e-19 9.3094647622391e-17 1.23064334815611 0.709876543209877 11.3 11 3 abnormal embryo turning 2.38448289353321e-07 6.62726390800432e-06 1.22928137132811 0.709090909090909 11.3 11 3 pallor 2.85974061323712e-20 5.92800397952278e-18 1.2283807988949 0.708571428571429 11.3 11 3 oligodactyly 1.47389371766111e-06 3.41052150947164e-05 1.22796803652968 0.708333333333333 11.3 11 3 vertebral transformation 1.47389371766111e-06 3.41052150947164e-05 1.22796803652968 0.708333333333333 11.3 11 3 abnormal foregut morphology 0.000680521949140875 0.00693769814954068 1.22796803652968 0.708333333333333 11.3 11 3 abnormal truncus arteriosus septation 0.000680521949140875 0.00693769814954068 1.22796803652968 0.708333333333333 11.3 11 3 abnormal lung saccule morphology 0.000680521949140875 0.00693769814954068 1.22796803652968 0.708333333333333 11.3 11 3 abnormal extraembryonic tissue morphology 2.99514917180281e-12 2.01363069320527e-10 1.22371901218183 0.705882352941177 11.3 11 3 failure of chorioallantoic fusion 8.28894304736417e-07 2.05161650052919e-05 1.22371901218183 0.705882352941177 11.3 11 3 abnormal dorsal-ventral axis patterning 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 abnormal embryonic-extraembryonic boundary morphology 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 abnormal ectoplacental cone morphology 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 abnormal tarsal bone morphology 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 increased brain size 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 increased hepatoma incidence 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 increased circulating alanine transaminase level 1.15942231021754e-09 5.05975964327392e-08 1.22241162007479 0.705128205128205 11.3 11 3 abnormal cell cycle 1.61395405293258e-13 1.33823690222326e-11 1.22105875345969 0.704347826086957 11.3 11 3 embryonic lethality before implantation, complete penetrance 1.53227364969641e-14 1.65718726244339e-12 1.22045576148268 0.704 11.3 11 3 embryonic growth arrest 2.77892608457834e-25 9.2167715138515e-23 1.21882057363234 0.703056768558952 11.3 11 3 increased erythroid progenitor cell number 3.22730215590295e-05 0.000509708832559275 1.21820676437921 0.702702702702703 11.3 11 3 abnormal chromosome morphology 3.22730215590295e-05 0.000509708832559275 1.21820676437921 0.702702702702703 11.3 11 3 abnormal humerus morphology 3.22730215590295e-05 0.000509708832559275 1.21820676437921 0.702702702702703 11.3 11 3 increased cellular sensitivity to gamma-irradiation 2.88108997424466e-06 6.15168352869837e-05 1.21720986850001 0.702127659574468 11.3 11 3 embryonic lethality during organogenesis, complete penetrance 1.66809507848086e-59 2.07469325386057e-56 1.21661707148613 0.701785714285714 11.3 11 3 abnormal cell morphology 3.12888545796071e-13 2.55183691038599e-11 1.2165627606486 0.701754385964912 11.3 11 3 abnormal incisor morphology 1.47598633254304e-07 4.26920465372189e-06 1.21352135374698 0.7 11.3 11 3 abnormal optic cup morphology 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal brain vasculature morphology 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal fat pad morphology 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal cellular respiration 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal pericardium morphology 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 abnormal circulating enzyme level 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 abnormal lens epithelium morphology 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 kidney atrophy 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 abnormal auchene hair morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 increased cranium width 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 jaundice 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal prostate gland epithelium morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal epidermis suprabasal layer morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal gland morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal tibialis anterior morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 aneurysm 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal pillar cell morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal embryonic erythrocyte morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal placental transport 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal deltoid tuberosity morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal corneal endothelium morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 protruding tongue 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal cerebellar granule cell migration 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal left subclavian artery morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 thick aortic valve cusps 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 thick aortic valve 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 decreased circulating lactate level 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 increased fatty acid oxidation 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal embryo size 6.04379429869462e-13 4.55573888424329e-11 1.21198719274351 0.699115044247788 11.3 11 3 embryonic lethality, complete penetrance 7.1668463414258e-34 3.96167339428815e-31 1.21189100710065 0.699059561128527 11.3 11 3 abnormal neural tube closure 7.20164758278901e-10 3.22776547066444e-08 1.21143267671815 0.698795180722892 11.3 11 3 decreased susceptibility to hepatic steatosis 8.30750272910461e-08 2.58311412983096e-06 1.21076960464551 0.698412698412698 11.3 11 3 preweaning lethality, complete penetrance 2.07877932766679e-76 1.03419271551423e-72 1.20883594311475 0.697297297297297 11.3 11 3 increased bone mineral content 2.05210148363171e-12 1.43791618043208e-10 1.20874997227746 0.697247706422018 11.3 11 3 decreased bone mineral content 2.42158339342263e-22 6.69298743459866e-20 1.20852057893758 0.697115384615385 11.3 11 3 increased cardiomyocyte apoptosis 0.00011340201197228 0.00151842044933279 1.20826801455327 0.696969696969697 11.3 11 3 abnormal somite development 2.45523076323083e-09 1.01789775392278e-07 1.20693805526372 0.69620253164557 11.3 11 3 abnormal allantois morphology 5.5852053578891e-06 0.00011295283193292 1.20598395403426 0.695652173913043 11.3 11 3 hypotension 0.00133842283036472 0.0120846707460335 1.20598395403426 0.695652173913043 11.3 11 3 abnormal hepatocyte physiology 0.00133842283036472 0.0120846707460335 1.20598395403426 0.695652173913043 11.3 11 3 abnormal hematopoietic stem cell physiology 0.00133842283036472 0.0120846707460335 1.20598395403426 0.695652173913043 11.3 11 3 heart right ventricle hypertrophy 6.27247744642146e-05 0.000915119510145067 1.20389023189184 0.694444444444444 11.3 11 3 hemorrhage 1.48115982086843e-24 4.60548131801278e-22 1.20245580948789 0.693617021276596 11.3 11 3 small liver 4.70894747213787e-09 1.88927529628112e-07 1.20018595425525 0.692307692307692 11.3 11 3 abnormal placenta vasculature 1.743516110747e-06 4.01573733841034e-05 1.20018595425525 0.692307692307692 11.3 11 3 heart inflammation 0.000728896410490305 0.00738545751973374 1.20018595425525 0.692307692307692 11.3 11 3 absent myocardial trabeculae 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal renal/urinary system morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased foot pad pigmentation 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 tight skin 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal grip strength 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased pituitary adenoma incidence 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal pulmonary alveolus epithelial cell morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal tail bud morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal bile duct development 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal coping response 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal telomere length 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 axonal dystrophy 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased circulating thyroid-stimulating hormone level 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal exocrine pancreas morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased circulating ammonia level 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased prostaglandin level 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased circulating calcium level 9.75400961874227e-07 2.40228702243776e-05 1.19776133616585 0.690909090909091 11.3 11 3 decreased liver weight 2.83891316695393e-08 1.00882807182827e-06 1.1964295036942 0.690140845070423 11.3 11 3 decreased trophoblast giant cell number 0.000398736839916846 0.00445778826648609 1.19558754063742 0.689655172413793 11.3 11 3 abnormal outer ear morphology 0.000398736839916846 0.00445778826648609 1.19558754063742 0.689655172413793 11.3 11 3 lethality throughout fetal growth and development, complete penetrance 1.14283028109113e-19 2.18676178785706e-17 1.19527291233725 0.689473684210526 11.3 11 3 trabecula carnea hypoplasia 1.07333360823406e-05 0.000196317452241341 1.19425911003671 0.688888888888889 11.3 11 3 decreased circulating HDL cholesterol level 1.39296271729681e-13 1.17457449466977e-11 1.19185132957293 0.6875 11.3 11 3 small heart 5.9769217387285e-06 0.000118940742600697 1.19185132957293 0.6875 11.3 11 3 failure of tooth eruption 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 intraventricular hemorrhage 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 abnormal molar crown morphology 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 blepharitis 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 dystonia 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 decreased circulating triiodothyronine level 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 decreased fibroblast apoptosis 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 abnormal vitelline vasculature morphology 2.58591143645028e-12 1.78679297171391e-10 1.19090915460884 0.68695652173913 11.3 11 3 increased mean corpuscular hemoglobin 8.5391958863751e-11 4.47184205628591e-09 1.19075688390757 0.686868686868687 11.3 11 3 abnormal embryonic epiblast morphology 0.000120582941079911 0.00159547907412915 1.18875561183377 0.685714285714286 11.3 11 3 decreased circulating thyroxine level 0.000120582941079911 0.00159547907412915 1.18875561183377 0.685714285714286 11.3 11 3 increased hepatocellular carcinoma incidence 1.03924467062274e-06 2.54691735780695e-05 1.18614869163238 0.684210526315789 11.3 11 3 impaired branching involved in ureteric bud morphogenesis 6.65889428809631e-05 0.000963023229165091 1.18614869163238 0.684210526315789 11.3 11 3 abnormal triglyceride level 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 irregular coat pigmentation 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 decreased germ cell number 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 abnormal optic vesicle formation 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 increased left ventricle weight 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 increased liver cholesterol level 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 decreased liver glycogen level 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 abnormal embryo development 4.75946091953995e-14 4.83230981116557e-12 1.18547779305114 0.683823529411765 11.3 11 3 abnormal placenta labyrinth morphology 9.57697556337717e-09 3.63705751357263e-07 1.1849937269862 0.683544303797468 11.3 11 3 prenatal lethality, complete penetrance 4.06991664262719e-27 1.55752579208233e-24 1.18483585412089 0.683453237410072 11.3 11 3 lethality at weaning, incomplete penetrance 3.68553724166501e-05 0.000576589552744763 1.18392327194827 0.682926829268293 11.3 11 3 muscular atrophy 2.04386298271343e-05 0.00034585776663263 1.18200131858472 0.681818181818182 11.3 11 3 abnormal mesenteric lymph node morphology 0.00259017569140584 0.0207506023586861 1.18200131858472 0.681818181818182 11.3 11 3 increased adenoma incidence 0.00259017569140584 0.0207506023586861 1.18200131858472 0.681818181818182 11.3 11 3 lethality throughout fetal growth and development, incomplete penetrance 8.61704412480807e-18 1.38289659744904e-15 1.18156109462994 0.681564245810056 11.3 11 3 perinatal lethality, incomplete penetrance 4.70945080134289e-22 1.17147588683404e-19 1.18130397267405 0.68141592920354 11.3 11 3 increased grip strength 9.59308551456679e-10 4.22350446327166e-08 1.18113538355279 0.681318681318681 11.3 11 3 microcephaly 1.02113184983137e-07 3.11664475638715e-06 1.18085928832522 0.681159420289855 11.3 11 3 abnormal interventricular septum morphology 6.31686730190039e-06 0.000123726042625805 1.17884931506849 0.68 11.3 11 3 decreased circulating alkaline phosphatase level 6.31686730190039e-06 0.000123726042625805 1.17884931506849 0.68 11.3 11 3 spontaneous skin ulceration 0.00140211695107788 0.0125685258227252 1.17884931506849 0.68 11.3 11 3 enlarged kidney 3.51914904451149e-06 7.45011340274241e-05 1.17754093625044 0.679245283018868 11.3 11 3 increased circulating bilirubin level 3.51914904451149e-06 7.45011340274241e-05 1.17754093625044 0.679245283018868 11.3 11 3 abnormal mitotic spindle morphology 0.000763287087768528 0.00764054982223023 1.17637274087717 0.678571428571429 11.3 11 3 increased insulin sensitivity 3.02736591028255e-14 3.1377386257616e-12 1.17593977336121 0.678321678321678 11.3 11 3 short limbs 3.20183206957699e-09 1.31645574761533e-07 1.17566108162679 0.67816091954023 11.3 11 3 osteopetrosis 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 abnormal postnatal growth/weight/body size 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 inner cell mass degeneration 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 decreased neuronal precursor cell number 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 abnormal brain morphology 9.8281754034214e-16 1.16417077695289e-13 1.17368081240835 0.677018633540373 11.3 11 3 decreased circulating serum albumin level 3.20952540432308e-10 1.55023193072887e-08 1.17324575326187 0.676767676767677 11.3 11 3 abnormal endoderm development 0.000229125606322376 0.00280073683403888 1.17273072000758 0.676470588235294 11.3 11 3 abnormal respiratory electron transport chain 0.000126165926350017 0.00165613584061038 1.17135265805693 0.675675675675676 11.3 11 3 abnormal blood homeostasis 1.82136230850522e-11 1.02969062327426e-09 1.17094165712428 0.675438596491228 11.3 11 3 edema 1.86412290765931e-16 2.5761142960014e-14 1.16917339729775 0.674418604651163 11.3 11 3 abnormal forelimb morphology 2.13728062462074e-05 0.0003592219968746 1.16829695547069 0.673913043478261 11.3 11 3 polydactyly 5.98387397499527e-10 2.75646046533347e-08 1.16752783305103 0.673469387755102 11.3 11 3 increased sarcoma incidence 1.18711200299644e-05 0.00021244180629163 1.16752783305103 0.673469387755102 11.3 11 3 abnormal neural tube morphology 1.92308689358586e-15 2.17439938536128e-13 1.16643586912188 0.672839506172839 11.3 11 3 decreased hematocrit 6.2191426763969e-14 6.06671270883815e-12 1.16365061318203 0.671232876712329 11.3 11 3 abnormal visceral yolk sac morphology 3.52992861707519e-08 1.22806957132511e-06 1.16304939870868 0.670886075949367 11.3 11 3 small kidney 6.24843189915226e-09 2.46713878557798e-07 1.16230129660831 0.670454545454545 11.3 11 3 abnormal liver morphology 1.15452595641895e-16 1.68934312740714e-14 1.16219124061961 0.670391061452514 11.3 11 3 abnormal liver physiology 6.24691420754948e-10 2.85122919106043e-08 1.16151329572925 0.67 11.3 11 3 cataract 1.12301682632786e-11 6.73133579636277e-10 1.16051038551954 0.669421487603306 11.3 11 3 increased blood urea nitrogen level 1.14961218921089e-13 1.02130725737931e-11 1.15971991441829 0.668965517241379 11.3 11 3 decreased erythrocyte cell number 1.16623458790282e-14 1.28933712773701e-12 1.15941530612769 0.668789808917197 11.3 11 3 abnormal kidney development 2.12567189273619e-06 4.78516636486992e-05 1.15573462261617 0.666666666666667 11.3 11 3 increased erythrocyte cell number 2.12567189273619e-06 4.78516636486992e-05 1.15573462261617 0.666666666666667 11.3 11 3 muscular ventricular septal defect 2.12567189273619e-06 4.78516636486992e-05 1.15573462261617 0.666666666666667 11.3 11 3 abnormal fontanelle morphology 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 macrocytosis 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 placental labyrinth hypoplasia 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 delayed intramembranous bone ossification 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 abnormal glial cell morphology 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 abnormal olfactory nerve morphology 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 abnormal secondary palate development 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 increased exploration in new environment 3.66355893506457e-08 1.2569797035825e-06 1.15573462261617 0.666666666666667 11.3 11 3 increased rib number 6.53051794962027e-08 2.05628650628866e-06 1.15573462261617 0.666666666666667 11.3 11 3 abnormal cornea morphology 6.53051794962027e-08 2.05628650628866e-06 1.15573462261617 0.666666666666667 11.3 11 3 abnormal forebrain development 2.07884854535441e-07 5.87629063246488e-06 1.15573462261617 0.666666666666667 11.3 11 3 failure of heart looping 0.000130238364085184 0.00169641195832865 1.15573462261617 0.666666666666667 11.3 11 3 abnormal lysosome morphology 0.000236299274311306 0.0028649829872829 1.15573462261617 0.666666666666667 11.3 11 3 narrow eye opening 0.000236299274311306 0.0028649829872829 1.15573462261617 0.666666666666667 11.3 11 3 abnormal epidermis stratum basale morphology 0.000429997776915704 0.00472238176634796 1.15573462261617 0.666666666666667 11.3 11 3 decreased brown adipose tissue amount 0.000429997776915704 0.00472238176634796 1.15573462261617 0.666666666666667 11.3 11 3 abnormal QRS complex 0.000429997776915704 0.00472238176634796 1.15573462261617 0.666666666666667 11.3 11 3 thin epidermis 0.00143993074272573 0.0127922418661795 1.15573462261617 0.666666666666667 11.3 11 3 abnormal palate morphology 0.00143993074272573 0.0127922418661795 1.15573462261617 0.666666666666667 11.3 11 3 abnormal bone trabecula morphology 0.00143993074272573 0.0127922418661795 1.15573462261617 0.666666666666667 11.3 11 3 ocular hypertelorism 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 abnormal nursing 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 hemolytic anemia 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 blindness 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 increased hemangiosarcoma incidence 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 abnormal osteoblast morphology 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 increased body temperature 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 abnormal eye pigmentation 0.0049243373066822 0.0340202648499215 1.15573462261617 0.666666666666667 11.3 11 3 left pulmonary isomerism 0.0049243373066822 0.0340202648499215 1.15573462261617 0.666666666666667 11.3 11 3 abnormal phrenic nerve morphology 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 abnormal iron level 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 absent allantois 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 increased circulating renin level 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 decreased lactate dehydrogenase level 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 small thoracic cage 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 abnormal metanephric mesenchyme morphology 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 mesocardia 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 abnormal respiratory function 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 small thyroid gland 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 decreased circulating ketone body level 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 hematuria 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 abnormal fatty acid level 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 abnormal thymus corticomedullary boundary morphology 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 distorted hair follicle pattern 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 crypts of Lieberkuhn abscesses 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 renal tubular acidosis 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal urinary bladder urothelium morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 synostosis 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal geniculate ganglion morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal lens vesicle development 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal kindling response 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased level of surface class I molecules 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased pheochromocytoma incidence 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal posterior semicircular canal morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal postural reflex 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased circulating bicarbonate level 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal lens capsule morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 biliary cyst 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 premature bone ossification 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 premature neuronal precursor differentiation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased fear-related response 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased cellular sensitivity to ionizing radiation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 small scapula 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased neuronal precursor cell number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal gallbladder physiology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal posterior eye segment morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal intervertebral disk development 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 hemothorax 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 absent adrenal gland 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal inguinal fat pad morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased susceptibility to atherosclerosis 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 enhanced conditioned place preference behavior 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal liver vasculature morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal hippocampus granule cell morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal cerebellar layer morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal incisor color 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal telomere morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 shortened ST segment 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 iris coloboma 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal pulmonary alveolar parenchyma morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal oxidative phosphorylation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased pancreatic beta cell proliferation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased myeloid cell number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal ductus venosus valve topology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal coronary sinus connection 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased cardiac muscle glycogen level 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased platelet dense granule number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 double outlet right ventricle 3.77665662369899e-10 1.7894158764669e-08 1.15033399353852 0.663551401869159 11.3 11 3 perinatal lethality, complete penetrance 1.43421771452394e-18 2.46042521715745e-16 1.14759564640056 0.661971830985915 11.3 11 3 decreased total body fat amount 3.1357785666971e-28 1.41822712448346e-25 1.14708391436305 0.661676646706587 11.3 11 3 pericardial effusion 2.18556559159529e-06 4.89783280098494e-05 1.1464141821112 0.661290322580645 11.3 11 3 decreased circulating cholesterol level 4.34092894568883e-16 5.68318986968472e-14 1.14626138800456 0.66120218579235 11.3 11 3 extramedullary hematopoiesis 6.90529623217485e-10 3.12307715955181e-08 1.14483146579904 0.660377358490566 11.3 11 3 increased B cell derived lymphoma incidence 2.26529047373831e-05 0.000374625783593955 1.14417727639001 0.66 11.3 11 3 abnormal embryonic tissue morphology 4.13262730398674e-13 3.21247200583344e-11 1.14394141218131 0.659863945578231 11.3 11 3 hepatic necrosis 4.07842727149268e-05 0.000618602916941344 1.1434395734394 0.659574468085106 11.3 11 3 abnormal cell nucleus morphology 4.07842727149268e-05 0.000618602916941344 1.1434395734394 0.659574468085106 11.3 11 3 increased respiratory quotient 4.07842727149268e-05 0.000618602916941344 1.1434395734394 0.659574468085106 11.3 11 3 osteoporosis 7.35547516385568e-05 0.00103080250535724 1.14260127463189 0.659090909090909 11.3 11 3 renal interstitial fibrosis 7.35547516385568e-05 0.00103080250535724 1.14260127463189 0.659090909090909 11.3 11 3 decreased blood urea nitrogen level 7.35547516385568e-05 0.00103080250535724 1.14260127463189 0.659090909090909 11.3 11 3 thick ventricular wall 0.000132918164536076 0.00171757887939475 1.14164029795012 0.658536585365854 11.3 11 3 abnormal cell differentiation 0.000132918164536076 0.00171757887939475 1.14164029795012 0.658536585365854 11.3 11 3 abnormal myocardium layer morphology 1.23094307382254e-07 3.66703101333362e-06 1.14110507043115 0.658227848101266 11.3 11 3 astrocytosis 3.91465207137612e-07 1.04706419651055e-05 1.13990264148444 0.657534246575342 11.3 11 3 abnormal liver development 0.000437165714703769 0.00474868871321234 1.13922412800737 0.657142857142857 11.3 11 3 thick pulmonary interalveolar septum 0.000437165714703769 0.00474868871321234 1.13922412800737 0.657142857142857 11.3 11 3 increased red blood cell distribution width 0.000437165714703769 0.00474868871321234 1.13922412800737 0.657142857142857 11.3 11 3 failure of primitive streak formation 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal lumbar vertebrae morphology 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal embryonic hematopoiesis 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal spongiotrophoblast layer morphology 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 bradykinesia 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal embryonic neuroepithelium morphology 7.15158370326991e-06 0.000137371154145822 1.13580816360555 0.655172413793103 11.3 11 3 abnormal retinal pigmentation 3.9611028722026e-08 1.32258300598711e-06 1.13580816360555 0.655172413793103 11.3 11 3 abnormal platelet physiology 1.28227208731752e-05 0.000226216440936336 1.13472126584133 0.654545454545455 11.3 11 3 abnormal ureter morphology 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 thick skin 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 abnormal erythrocyte osmotic lysis 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 decreased bone resorption 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 abnormal lipid homeostasis 2.37170200447225e-11 1.31102416358327e-09 1.13350895679663 0.653846153846154 11.3 11 3 decreased body length 3.32735375811931e-22 8.71241312981241e-20 1.13253556997241 0.653284671532847 11.3 11 3 increased tumor incidence 7.44608757033063e-11 3.94088145344626e-09 1.13243352135375 0.653225806451613 11.3 11 3 decreased circulating creatinine level 4.13777412097837e-05 0.000623800795511133 1.13214820174645 0.653061224489796 11.3 11 3 abnormal bone structure 4.88968878597757e-16 6.23748761800985e-14 1.13178157344278 0.652849740932642 11.3 11 3 abnormal digit morphology 7.10559132323091e-07 1.79732291752237e-05 1.13165681797833 0.652777777777778 11.3 11 3 abnormal cell death 7.44924880739359e-05 0.00103713925895487 1.13060995690712 0.652173913043478 11.3 11 3 dilated heart 0.00493721230585795 0.0340202648499215 1.13060995690712 0.652173913043478 11.3 11 3 abnormal corneal stroma morphology 0.00493721230585795 0.0340202648499215 1.13060995690712 0.652173913043478 11.3 11 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00493721230585795 0.0340202648499215 1.13060995690712 0.652173913043478 11.3 11 3 prenatal lethality, incomplete penetrance 3.65013720653761e-24 1.06820191779556e-21 1.12912231222698 0.651315789473684 11.3 11 3 abnormal organ of Corti morphology 0.000134340132143045 0.00171810323242069 1.128857073253 0.651162790697674 11.3 11 3 abnormal homeostasis 0.000134340132143045 0.00171810323242069 1.128857073253 0.651162790697674 11.3 11 3 abnormal double-strand DNA break repair 0.000134340132143045 0.00171810323242069 1.128857073253 0.651162790697674 11.3 11 3 increased circulating aspartate transaminase level 4.04625685021612e-06 8.33840748122046e-05 1.1282171316015 0.650793650793651 11.3 11 3 intracranial hemorrhage 7.23707592498921e-06 0.000137733364123757 1.12684125705077 0.65 11.3 11 3 decreased circulating phosphate level 0.000242746051867736 0.00291002797118551 1.12684125705077 0.65 11.3 11 3 increased urine glucose level 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal trachea morphology 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 decreased myocardial infarction size 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 absent placental labyrinth 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal physiological neovascularization 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal postnatal subventricular zone morphology 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 increased urine calcium level 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal enzyme/coenzyme activity 4.57365622077045e-13 3.50060610743584e-11 1.12628915452404 0.64968152866242 11.3 11 3 decreased circulating glucose level 6.27248589389287e-22 1.43402523216177e-19 1.12466648759961 0.648745519713262 11.3 11 3 small spleen 4.07408305963208e-08 1.34228895507746e-06 1.1239836714454 0.648351648351648 11.3 11 3 abnormal osteoblast physiology 2.32190794736625e-05 0.000378737443873676 1.12363088309905 0.648148148148148 11.3 11 3 abnormal eye morphology 1.39934918954083e-11 8.19030849172425e-10 1.12247607232506 0.647482014388489 11.3 11 3 abnormal brown adipose tissue morphology 0.00079826342300347 0.00778698143027895 1.12174242783334 0.647058823529412 11.3 11 3 abnormal direction of heart looping 0.00079826342300347 0.00778698143027895 1.12174242783334 0.647058823529412 11.3 11 3 nephrocalcinosis 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 absence seizures 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal duodenum morphology 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal involuntary movement 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 coloboma 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal cell cytoskeleton morphology 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal osteoclast morphology 7.48408028069947e-05 0.00103713925895487 1.11961791565941 0.645833333333333 11.3 11 3 abnormal nervous system morphology 4.06564665247898e-07 1.07939737513924e-05 1.11916074215363 0.645569620253165 11.3 11 3 prenatal lethality 7.27907629486279e-06 0.000137733364123757 1.11845286059629 0.645161290322581 11.3 11 3 abnormal eyelid morphology 0.00145394649773853 0.0128418072111102 1.11845286059629 0.645161290322581 11.3 11 3 abnormal nose morphology 0.00145394649773853 0.0128418072111102 1.11845286059629 0.645161290322581 11.3 11 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00145394649773853 0.0128418072111102 1.11845286059629 0.645161290322581 11.3 11 3 abnormal thoracic vertebrae morphology 1.30088682352373e-05 0.000227884223486991 1.11655717778172 0.644067796610169 11.3 11 3 seminiferous tubule degeneration 1.28738276631222e-06 3.06581462626703e-05 1.11615466978685 0.643835616438356 11.3 11 3 decreased percent body fat/body weight 1.28738276631222e-06 3.06581462626703e-05 1.11615466978685 0.643835616438356 11.3 11 3 abnormal pancreas morphology 0.000242637789569921 0.00291002797118551 1.11445838609416 0.642857142857143 11.3 11 3 corneal vascularization 0.00265788932164871 0.0208821583297937 1.11445838609416 0.642857142857143 11.3 11 3 extended life span 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 absent visceral yolk sac blood islands 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 increased lactate dehydrogenase level 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 amyloid beta deposits 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 failure of zygotic cell division 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal sagittal suture morphology 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal decidualization 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal viscerocranium morphology 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal glucose tolerance 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 spina bifida occulta 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 pulmonary alveolar hemorrhage 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 enlarged spleen 1.1686827770252e-21 2.52791165900017e-19 1.11359846449996 0.642361111111111 11.3 11 3 increased neuron apoptosis 4.07892877439554e-07 1.07939737513924e-05 1.11292963659335 0.641975308641975 11.3 11 3 thrombocytopenia 1.42800716850406e-11 8.26085542245082e-10 1.1118964127928 0.641379310344828 11.3 11 3 decreased caudal vertebrae number 7.28118085719558e-06 0.000137733364123757 1.11058873892023 0.640625 11.3 11 3 decreased rib number 1.2957723363143e-07 3.81447773559979e-06 1.11028438464812 0.640449438202247 11.3 11 3 enlarged liver 2.33028824014912e-08 8.40085796720424e-07 1.10950523771152 0.64 11.3 11 3 delayed bone ossification 1.28795026510514e-06 3.06581462626703e-05 1.10950523771152 0.64 11.3 11 3 abnormal hindlimb morphology 7.46663393829403e-05 0.00103713925895487 1.10950523771152 0.64 11.3 11 3 short stride length 7.46663393829403e-05 0.00103713925895487 1.10950523771152 0.64 11.3 11 3 abnormal thyroid gland morphology 0.00488019373367372 0.0339091673533893 1.10950523771152 0.64 11.3 11 3 diaphragmatic hernia 0.00488019373367372 0.0339091673533893 1.10950523771152 0.64 11.3 11 3 embryonic lethality during organogenesis, incomplete penetrance 3.15064538557792e-17 4.7498366040152e-15 1.10799775776898 0.639130434782609 11.3 11 3 abnormal axon morphology 7.44190369089693e-09 2.87003650094668e-07 1.1075790133405 0.638888888888889 11.3 11 3 hydrops fetalis 2.28987275718559e-06 5.04748360393878e-05 1.1075790133405 0.638888888888889 11.3 11 3 abnormal tibia morphology 0.0001339775740016 0.00171810323242069 1.1065544259091 0.638297872340426 11.3 11 3 spleen hypoplasia 1.31581940542438e-08 4.81338348675462e-07 1.10620313878976 0.638095238095238 11.3 11 3 glomerulosclerosis 2.31834917255449e-05 0.000378737443873676 1.10591847508961 0.637931034482759 11.3 11 3 thrombocytosis 2.31834917255449e-05 0.000378737443873676 1.10591847508961 0.637931034482759 11.3 11 3 hyperkeratosis 4.07283018680718e-06 8.33840748122046e-05 1.10548529119808 0.63768115942029 11.3 11 3 increased lymphocyte cell number 4.07283018680718e-06 8.33840748122046e-05 1.10548529119808 0.63768115942029 11.3 11 3 perimembraneous ventricular septal defect 4.07283018680718e-06 8.33840748122046e-05 1.10548529119808 0.63768115942029 11.3 11 3 abnormal retinal pigment epithelium morphology 7.23040739811105e-07 1.80760184952776e-05 1.10517123287671 0.6375 11.3 11 3 abnormal tail morphology 7.24713959786744e-06 0.000137733364123757 1.10320123067907 0.636363636363636 11.3 11 3 abnormal astrocyte morphology 0.000240714548025899 0.00289964861120787 1.10320123067907 0.636363636363636 11.3 11 3 dextrocardia 0.00143741492208968 0.0127922418661795 1.10320123067907 0.636363636363636 11.3 11 3 abnormal tail movements 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 intestinal inflammation 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 testis hypoplasia 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 aphakia 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 decreased cardiac output 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 prolonged PR interval 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 abnormal basement membrane morphology 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 increased mammary gland tumor incidence 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 increased bone volume 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 decreased atrioventricular cushion size 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal hemoglobin 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 focal hepatic necrosis 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 secondary sex reversal 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal bronchiole morphology 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 retinal detachment 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 patent ductus arteriosus 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 fused joints 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 increased circulating triiodothyronine level 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal aorta smooth muscle morphology 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal pulmonary alveolar sac morphology 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 decreased embryonic cilium length 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal angiogenesis 2.27736325383277e-06 5.04748360393878e-05 1.10107149857351 0.635135135135135 11.3 11 3 abnormal intestine morphology 2.27736325383277e-06 5.04748360393878e-05 1.10107149857351 0.635135135135135 11.3 11 3 anemia 1.64912167868949e-15 1.9079954305768e-13 1.10096046988555 0.635071090047393 11.3 11 3 hemopericardium 0.000433114389909281 0.00473570129626082 1.09935732395197 0.634146341463415 11.3 11 3 increased bone trabecula number 0.000433114389909281 0.00473570129626082 1.09935732395197 0.634146341463415 11.3 11 3 cleft palate 4.28299981708e-10 1.99139477476383e-08 1.09838901157033 0.633587786259542 11.3 11 3 epidermal hyperplasia 2.29783276802114e-05 0.000378533709301495 1.09794789148536 0.633333333333333 11.3 11 3 abnormal behavior 1.07987404696141e-19 2.14894935345322e-17 1.09753215960672 0.633093525179856 11.3 11 3 abnormal renal glomerulus morphology 1.30298574591762e-08 4.80174376736309e-07 1.09741773798875 0.63302752293578 11.3 11 3 decreased birth weight 1.2757301522205e-07 3.77783184958154e-06 1.09490648458374 0.631578947368421 11.3 11 3 incomplete somite formation 0.00078056865795518 0.00778222259183772 1.09490648458374 0.631578947368421 11.3 11 3 small superior vagus ganglion 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 thin dermal layer 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 abnormal long term depression 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 decreased tumor incidence 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 abnormal neural crest cell migration 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 absent amnion 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 decreased eye pigmentation 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 decreased susceptibility to weight gain 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 abnormal craniofacial morphology 4.05457634272592e-08 1.34228895507746e-06 1.09402063791336 0.631067961165049 11.3 11 3 hydronephrosis 7.11703748245041e-07 1.79732291752237e-05 1.09382026783316 0.630952380952381 11.3 11 3 abnormal myelin sheath morphology 0.000237260902665438 0.0028649829872829 1.09292295834355 0.630434782608696 11.3 11 3 atrial septal defect 0.000237260902665438 0.0028649829872829 1.09292295834355 0.630434782608696 11.3 11 3 abnormal chondrocyte morphology 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 abnormal mandible morphology 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 neurodegeneration 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 abnormal cell adhesion 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 decreased platelet aggregation 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 abnormal kidney morphology 1.4277275263858e-12 1.04027467940078e-10 1.08969264418096 0.628571428571429 11.3 11 3 abnormal blood circulation 0.000425390086477775 0.00470292373383762 1.08854074920825 0.627906976744186 11.3 11 3 abnormal dendritic spine morphology 0.000130257159413376 0.00169641195832865 1.08775023305051 0.627450980392157 11.3 11 3 internal hemorrhage 1.25605270931052e-05 0.000222379438748037 1.08673554066894 0.626865671641791 11.3 11 3 spleen hyperplasia 3.93816362776842e-06 8.19764186114974e-05 1.0863905452592 0.626666666666667 11.3 11 3 decreased circulating LDL cholesterol level 2.22683545212203e-05 0.000370518607836357 1.08350120870266 0.625 11.3 11 3 abnormal osteoclast physiology 2.22683545212203e-05 0.000370518607836357 1.08350120870266 0.625 11.3 11 3 abnormal tooth morphology 2.22683545212203e-05 0.000370518607836357 1.08350120870266 0.625 11.3 11 3 abnormal eye development 7.16524130652853e-05 0.00102729324207433 1.08350120870266 0.625 11.3 11 3 overriding aortic valve 0.000232538859325937 0.00283549221849642 1.08350120870266 0.625 11.3 11 3 abnormal digestive system morphology 0.00874219182760053 0.0528461778156897 1.08350120870266 0.625 11.3 11 3 decreased metastatic potential 0.00874219182760053 0.0528461778156897 1.08350120870266 0.625 11.3 11 3 abnormal primitive streak formation 0.00874219182760053 0.0528461778156897 1.08350120870266 0.625 11.3 11 3 vasculature congestion 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 abnormal hair follicle orientation 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 disorganized retinal layers 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 poor circulation 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 disorganized yolk sac vascular plexus 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 increased intestinal adenocarcinoma incidence 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 abnormal epicardium morphology 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 large intestinal inflammation 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 increased pancreatic beta cell number 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 increased thymus weight 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 kidney degeneration 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 decreased liver cholesterol level 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 abnormal ear pigmentation 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal exoccipital bone morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 schistocytosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 increased sensitivity to skin irradiation 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 dermal cysts 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 dry eyes 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 absent eyelids 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal erythrocyte cell number 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal neuron apoptosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 decreased susceptibility to age related obesity 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 loss of GABAergic neurons 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal perineum morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 liver failure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 increased left ventricle systolic pressure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal skin development 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal miscarriage rate 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 non-pigmented tail tip 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal somite size 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal ilium morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 hypergranulosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal mitotic spindle assembly checkpoint 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 skin fibrosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal olfactory bulb glomerular layer morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal brain ependyma morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 myocardial trabeculae hypoplasia 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 delayed suture closure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal heart right ventricle pressure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal maxillary prominence morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal bronchus epithelium morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 absent ureteric bud 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 decreased surfactant secretion 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 increased aorta wall thickness 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 lethality during fetal growth through weaning, incomplete penetrance 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 impaired neuron differentiation 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal heart echocardiography feature 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 prolonged PQ interval 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 absent hypoglossal canal 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 retropleural edema 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal vertebrae morphology 3.88776138709195e-08 1.31079805271838e-06 1.08151313309036 0.623853211009174 11.3 11 3 lethargy 3.85431617598147e-07 1.03649853921664e-05 1.08117109857642 0.623655913978495 11.3 11 3 cardiac fibrosis 1.21855149806009e-06 2.94286102080046e-05 1.08095179409395 0.623529411764706 11.3 11 3 abnormal sternum morphology 1.23207563504175e-05 0.000218913438726167 1.08036062548903 0.623188405797101 11.3 11 3 abnormal long bone morphology 3.94840145497902e-05 0.000611583953151631 1.07994874572331 0.622950819672131 11.3 11 3 increased granulocyte number 6.82428113297556e-06 0.000132620307174037 1.07764444541237 0.621621621621622 11.3 11 3 increased circulating phosphate level 0.00137234592556476 0.0123238645842684 1.07764444541237 0.621621621621622 11.3 11 3 decreased width of hypertrophic chondrocyte zone 0.00137234592556476 0.0123238645842684 1.07764444541237 0.621621621621622 11.3 11 3 alopecia 3.77829479793626e-07 1.02157699020288e-05 1.07665804317401 0.621052631578947 11.3 11 3 preweaning lethality, incomplete penetrance 5.87341566668856e-26 2.08716021012683e-23 1.07661342595785 0.621026894865526 11.3 11 3 dermatitis 7.00164059281321e-05 0.00100673878466028 1.07602878657368 0.620689655172414 11.3 11 3 lordosis 0.00462472766104104 0.0332485839793051 1.07602878657368 0.620689655172414 11.3 11 3 decreased leukocyte cell number 1.21724955279135e-09 5.22053148718706e-08 1.07559244075592 0.62043795620438 11.3 11 3 kyphosis 2.18367650202638e-10 1.06507750956679e-08 1.07483319903304 0.62 11.3 11 3 kidney inflammation 0.000226785528147056 0.00279271782804852 1.07483319903304 0.62 11.3 11 3 abnormal bone mineralization 1.19163144159435e-08 4.42415404621783e-07 1.07454665325884 0.619834710743802 11.3 11 3 increased circulating free fatty acid level 1.20437419683307e-05 0.00021475848133493 1.0743448604601 0.619718309859155 11.3 11 3 gliosis 3.8539995962893e-05 0.000601054795973018 1.07318214957216 0.619047619047619 11.3 11 3 abnormal reproductive system morphology 0.000742638865460742 0.00750940722696583 1.07318214957216 0.619047619047619 11.3 11 3 trunk curl 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 abnormal erythrocyte physiology 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 abnormal clavicle morphology 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 abnormal tumor vascularization 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 reduced fertility 1.19172774706163e-09 5.15551786228837e-08 1.07258824688839 0.618705035971223 11.3 11 3 abnormal rostral-caudal axis patterning 0.000124168735134959 0.00163856619972525 1.07168119551681 0.618181818181818 11.3 11 3 pericardial edema 2.12509453003457e-05 0.000358384585997356 1.0707541356591 0.617647058823529 11.3 11 3 abnormal retinal photoreceptor morphology 0.00246989042061356 0.0198946465605486 1.0707541356591 0.617647058823529 11.3 11 3 decreased heart weight 3.69202279321539e-06 7.71756865388511e-05 1.07012465057053 0.617283950617284 11.3 11 3 decreased bone marrow cell number 1.17356739782538e-05 0.000211020109768135 1.06865872639166 0.616438356164384 11.3 11 3 ventricular hypoplasia 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 abnormal kidney cortex morphology 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 increased leukemia incidence 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 abnormal nerve conduction 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 short premaxilla 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 absent common myeloid progenitor cells 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 absent trabeculae carneae 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 pup cannibalization 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 abnormal lung interstitium morphology 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 anal atresia 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 abnormal vertebral arch development 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 increased renin activity 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 abnormal spermatogenesis 6.43380489205544e-12 4.11511506418051e-10 1.06465770942087 0.614130434782609 11.3 11 3 incomplete embryo turning 0.000120500819322088 0.00159547907412915 1.06449241556752 0.614035087719298 11.3 11 3 abnormal heart development 1.98755044904459e-10 9.88806348399681e-09 1.06429992145983 0.613924050632911 11.3 11 3 decreased body weight 9.87701277674907e-73 2.45690692821633e-69 1.06424674457386 0.61389337641357 11.3 11 3 abnormal myelopoiesis 0.000718698294607228 0.00729698778708359 1.06380118672625 0.613636363636364 11.3 11 3 embryonic lethality, incomplete penetrance 0.000718698294607228 0.00729698778708359 1.06380118672625 0.613636363636364 11.3 11 3 abnormal capillary morphology 0.00445189560471258 0.0323331104137884 1.06253021756648 0.612903225806452 11.3 11 3 abnormal podocyte morphology 0.00445189560471258 0.0323331104137884 1.06253021756648 0.612903225806452 11.3 11 3 small cranium 0.00445189560471258 0.0323331104137884 1.06253021756648 0.612903225806452 11.3 11 3 abnormal definitive hematopoiesis 1.10474967002312e-06 2.69353062595668e-05 1.06253021756648 0.612903225806452 11.3 11 3 decreased bone mineral density 2.10676777204057e-16 2.83274855835184e-14 1.06231998206637 0.612781954887218 11.3 11 3 increased T cell derived lymphoma incidence 0.000390539745977469 0.0043858583210788 1.0613889391373 0.612244897959184 11.3 11 3 increased heart weight 3.35816669636571e-09 1.36941633724749e-07 1.06011629052922 0.611510791366906 11.3 11 3 thin ventricular wall 1.93246305520483e-06 4.43041645144886e-05 1.05942340406482 0.611111111111111 11.3 11 3 abnormal long bone epiphyseal plate proliferative zone 0.000213006477595745 0.00262954646659759 1.05942340406482 0.611111111111111 11.3 11 3 abnormal uterus morphology 0.00237862007524792 0.0194669114941458 1.05942340406482 0.611111111111111 11.3 11 3 abnormal limb bone morphology 0.00237862007524792 0.0194669114941458 1.05942340406482 0.611111111111111 11.3 11 3 lowered ear position 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 abnormal megakaryocyte differentiation 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 abnormal radius morphology 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 abnormal mammary gland morphology 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 absent ureter 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 long tibia 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 darkened coat color 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 jerky movement 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 increased gastrointestinal tumor incidence 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 decreased tumor latency 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 atrioventricular block 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 primary atelectasis 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 polyuria 1.10487160315903e-05 0.000200161756304237 1.0581726090187 0.61038961038961 11.3 11 3 azoospermia 3.26725503482754e-10 1.56294171137183e-08 1.05760621126197 0.610062893081761 11.3 11 3 abnormal lens morphology 1.82204851920401e-08 6.61656305331383e-07 1.05641367848509 0.609375 11.3 11 3 increased sacral vertebrae number 6.39237566119021e-05 0.00092988505597723 1.05641367848509 0.609375 11.3 11 3 abnormal ulna morphology 0.0153431989762836 0.0829700162032728 1.05523595977998 0.608695652173913 11.3 11 3 thymus hypoplasia 5.66469152919006e-09 2.25454722861764e-07 1.05523595977998 0.608695652173913 11.3 11 3 postnatal growth retardation 1.46882948768077e-34 9.13428337651478e-32 1.05375803826768 0.607843137254902 11.3 11 3 kinked tail 5.75829435916343e-07 1.48432717289316e-05 1.05375803826768 0.607843137254902 11.3 11 3 abnormal cervical vertebrae morphology 0.00037640449968426 0.00424628658940861 1.05375803826768 0.607843137254902 11.3 11 3 hunched posture 1.06797613995093e-05 0.000196058350415346 1.05332775732107 0.607594936708861 11.3 11 3 premature death 4.3797609704174e-48 4.35786216556532e-45 1.05304740004923 0.607433217189315 11.3 11 3 abnormal coat/hair pigmentation 1.77772578130406e-07 5.08286538045269e-06 1.05254403131115 0.607142857142857 11.3 11 3 abnormal jaw morphology 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 reddish skin 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 absent corpus callosum 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 failure of blastocyst to hatch from the zona pellucida 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 hypoxia 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 belly spot 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 single kidney 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 increased osteoblast cell number 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 myeloid hyperplasia 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 atelectasis 3.38870459079576e-05 0.000531823512277883 1.04992793181328 0.605633802816901 11.3 11 3 abnormal axial skeleton morphology 1.86667211224224e-05 0.000321338884373881 1.04928538105942 0.605263157894737 11.3 11 3 increased oxygen consumption 5.69122468892113e-06 0.000114630942620982 1.0482244251635 0.604651162790698 11.3 11 3 abnormal vasculogenesis 0.00122784288037586 0.0113330581259182 1.0482244251635 0.604651162790698 11.3 11 3 delayed endochondral bone ossification 0.00122784288037586 0.0113330581259182 1.0482244251635 0.604651162790698 11.3 11 3 curly tail 0.000664849499517129 0.00681984795896437 1.0473845017459 0.604166666666667 11.3 11 3 thymus atrophy 0.000664849499517129 0.00681984795896437 1.0473845017459 0.604166666666667 11.3 11 3 abnormal coat/ hair morphology 0.00036155981464811 0.00409740336645637 1.04670305444483 0.60377358490566 11.3 11 3 decreased circulating alanine transaminase level 5.92740198257526e-05 0.000867318378332704 1.04525998957198 0.602941176470588 11.3 11 3 decreased body size 5.46113345300109e-43 3.88130556124006e-40 1.0449405140571 0.602756892230576 11.3 11 3 short tail 9.91211741150582e-06 0.000182639941193487 1.0443385144122 0.602409638554217 11.3 11 3 increased spleen weight 2.87060344372764e-07 7.80396291395903e-06 1.0432294823615 0.601769911504425 11.3 11 3 abnormal rib morphology 2.64595176896205e-08 9.47022305797568e-07 1.04016116035455 0.6 11.3 11 3 abnormal limb morphology 3.12886110818436e-05 0.000498912949141577 1.04016116035455 0.6 11.3 11 3 decreased oocyte number 0.000636171072723085 0.00656148142097419 1.04016116035455 0.6 11.3 11 3 abnormal cell migration 0.00117362228812519 0.0109135904363043 1.04016116035455 0.6 11.3 11 3 small placenta 0.00117362228812519 0.0109135904363043 1.04016116035455 0.6 11.3 11 3 abnormal metabolism 0.00117362228812519 0.0109135904363043 1.04016116035455 0.6 11.3 11 3 ovary cysts 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 increased carcinoma incidence 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 holoprosencephaly 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 abnormal hippocampus pyramidal cell morphology 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 decreased bone volume 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 impaired adaptive thermogenesis 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 decreased bone mineralization 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 abnormal heart tube morphology 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 delayed eyelid opening 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 abnormal lactation 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 enhanced paired-pulse facilitation 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 ruffled hair 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 abnormal nest building behavior 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 abnormal keratinocyte physiology 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 abnormal vertebrae development 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 absent incisors 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 decreased chondrocyte number 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal epidermis stratum spinosum morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal apical ectodermal ridge morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal cricoid cartilage morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal lymph node B cell domain morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 dilated ureter 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal ear development 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 absent chorion 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal aorta wall morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 ostium primum atrial septal defect 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal coronary vessel morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 herniated liver 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal testis morphology 2.76066463577216e-07 7.63017031275918e-06 1.04016116035455 0.6 11.3 11 3 abnormal basioccipital bone morphology 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 small gonad 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 spleen atrophy 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 abnormal response to tactile stimuli 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 abnormal sperm mitochondrial sheath morphology 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 retarded hair growth 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 enlarged testis 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 decreased circulating parathyroid hormone level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 primary sex reversal 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 rickets 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal submandibular gland morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 increased atrioventricular cushion size 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 absent pharyngeal arches 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal ear physiology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal utricular macula morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal respiratory conducting tube morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 osteosclerosis 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 decreased thyroxine level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 increased circulating fructosamine level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal retinal blood vessel pattern 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 increased kidney iron level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal heart and great artery attachment 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 aorta stenosis 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 thin ventricle myocardium compact layer 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal pulmonary interalveolar septum morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 decreased trabecular bone connectivity density 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 reduced female fertility 3.96254445848991e-13 3.12915217158529e-11 1.03866667592876 0.599137931034483 11.3 11 3 abnormal myocardial fiber morphology 2.79487435689488e-06 5.9933189334276e-05 1.03658672337739 0.597938144329897 11.3 11 3 abnormal spleen morphology 4.10344199043102e-10 1.92590791532022e-08 1.03617586855243 0.597701149425287 11.3 11 3 abnormal craniofacial bone morphology 0.000330730460824786 0.0037912074714362 1.03407834655131 0.596491228070175 11.3 11 3 pulmonary hypoplasia 0.0011182681029946 0.0104574883691694 1.03278413084849 0.595744680851064 11.3 11 3 abnormal retina morphology 1.10316652721993e-11 6.69299204014528e-10 1.03190591305015 0.595238095238095 11.3 11 3 disheveled coat 0.0020700254163977 0.017454875333184 1.03190591305015 0.595238095238095 11.3 11 3 spina bifida 0.0020700254163977 0.017454875333184 1.03190591305015 0.595238095238095 11.3 11 3 abnormal long bone metaphysis morphology 0.00385448882811654 0.0290107139483809 1.0307903390901 0.594594594594595 11.3 11 3 abnormal vocalization 0.00385448882811654 0.0290107139483809 1.0307903390901 0.594594594594595 11.3 11 3 skin inflammation 0.00385448882811654 0.0290107139483809 1.0307903390901 0.594594594594595 11.3 11 3 abnormal vertebral body morphology 0.00723163031795032 0.0467238452361076 1.02932614826753 0.59375 11.3 11 3 abnormal lymphatic vessel morphology 0.00723163031795032 0.0467238452361076 1.02932614826753 0.59375 11.3 11 3 short snout 1.35764799422297e-06 3.21633274821871e-05 1.02731966454771 0.592592592592593 11.3 11 3 abnormal skeleton development 2.7349179457104e-05 0.000441760285061988 1.02731966454771 0.592592592592593 11.3 11 3 abnormal maxilla morphology 0.000577637395815186 0.00606275536746952 1.02731966454771 0.592592592592593 11.3 11 3 abnormal apoptosis 0.000577637395815186 0.00606275536746952 1.02731966454771 0.592592592592593 11.3 11 3 abnormal trigeminal ganglion morphology 0.0137039290462738 0.0757522744502357 1.02731966454771 0.592592592592593 11.3 11 3 thick interventricular septum 0.0137039290462738 0.0757522744502357 1.02731966454771 0.592592592592593 11.3 11 3 increased circulating LDL cholesterol level 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 absent kidney 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 abnormal respiratory system physiology 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 increased fluid intake 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 abnormal skeleton morphology 7.20071910950299e-07 1.80760184952776e-05 1.02508636092912 0.591304347826087 11.3 11 3 omphalocele 0.00196327394870835 0.0167534955314306 1.02440114277342 0.590909090909091 11.3 11 3 abnormal long bone epiphysis morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal enterocyte morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 increased body size 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 increased myocardial infarction size 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal lysosome physiology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal vascular branching morphogenesis 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 parakeratosis 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal blood-brain barrier function 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 cleft upper lip 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal temporal bone morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal sperm midpiece morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 pulmonary vascular congestion 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 increased circulating creatine kinase level 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal heart ventricle morphology 4.72353133880403e-05 0.000707818325618978 1.02238062769892 0.58974358974359 11.3 11 3 abnormal heart looping 0.00364701446551244 0.0277429617215969 1.02238062769892 0.58974358974359 11.3 11 3 abnormal cranium morphology 1.13008415243031e-07 3.4281516209395e-06 1.0220489013434 0.58955223880597 11.3 11 3 increased inflammatory response 7.59143912603465e-06 0.000143058369894024 1.02191271894482 0.589473684210526 11.3 11 3 abnormal gluconeogenesis 0.00100726617706426 0.00954504615408517 1.01976584348486 0.588235294117647 11.3 11 3 increased kidney weight 0.00100726617706426 0.00954504615408517 1.01976584348486 0.588235294117647 11.3 11 3 abnormal nervous system development 0.0068211800181456 0.0441866804560864 1.01976584348486 0.588235294117647 11.3 11 3 decreased osteoblast cell number 0.0068211800181456 0.0441866804560864 1.01976584348486 0.588235294117647 11.3 11 3 abnormal vagus nerve morphology 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 increased incidence of corneal inflammation 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 hyperlipidemia 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 abnormal survival 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 postnatal lethality, incomplete penetrance 1.98053153978455e-27 8.21095367535677e-25 1.01940677100476 0.588028169014085 11.3 11 3 abnormal glucose homeostasis 8.82411264376087e-10 3.91963932167056e-08 1.01920553258184 0.587912087912088 11.3 11 3 abnormal hair follicle morphology 0.000284359635080777 0.00336030685160776 1.01814716754282 0.587301587301587 11.3 11 3 small testis 5.87713838466467e-14 5.84775269274135e-12 1.01754896121641 0.58695652173913 11.3 11 3 enlarged heart 6.67699314892166e-12 4.20481530580826e-10 1.0162494095418 0.586206896551724 11.3 11 3 abnormal mammary gland development 0.00344133310852572 0.0262184260565321 1.01479137595566 0.585365853658537 11.3 11 3 palatal shelves fail to meet at midline 0.00344133310852572 0.0262184260565321 1.01479137595566 0.585365853658537 11.3 11 3 abnormal pancreatic islet morphology 0.000952783964556027 0.0090947846272699 1.01399358399343 0.584905660377358 11.3 11 3 impaired glucose tolerance 1.80792986640165e-12 1.28492158362118e-10 1.01359790491539 0.584677419354839 11.3 11 3 decreased grip strength 3.61432936379009e-11 1.97596577855557e-09 1.01324679243061 0.584474885844749 11.3 11 3 retinal degeneration 1.17492603830701e-05 0.000211020109768135 1.01126779478915 0.583333333333333 11.3 11 3 abnormal kidney physiology 0.00175305414786304 0.0152472803944382 1.01126779478915 0.583333333333333 11.3 11 3 abnormal adrenal gland morphology 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal body weight 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal tumor morphology 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 decreased fatty acid level 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal inner cell mass apoptosis 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal adipose tissue distribution 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal glossopharyngeal nerve morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 absent optic nerve 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 impaired embryo implantation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal thymus involution 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 myocarditis 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal corticospinal tract morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 increased urine phosphate level 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal aorta elastic fiber morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 loss of dopaminergic neurons 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 small intestinal inflammation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal vascular endothelial cell development 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 impaired sperm capacitation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal defecation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 decreased renal glomerular filtration rate 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 reduced cerebellar foliation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 decreased prostaglandin level 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 decreased mammary gland epithelial cell proliferation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 increased fibrosarcoma incidence 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 increased type II pneumocyte number 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal colon goblet cell morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal seminiferous tubule morphology 8.37172246543133e-08 2.58691424009446e-06 1.00928879714768 0.582191780821918 11.3 11 3 small seminiferous tubules 0.000132551952324788 0.00171757887939475 1.00736328592896 0.581081081081081 11.3 11 3 abnormal retinal photoreceptor layer morphology 0.0120546674442677 0.0675360028549906 1.00660757453666 0.580645161290323 11.3 11 3 preaxial polydactyly 0.0120546674442677 0.0675360028549906 1.00660757453666 0.580645161290323 11.3 11 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0120546674442677 0.0675360028549906 1.00660757453666 0.580645161290323 11.3 11 3 hypoglycemia 2.00639445397953e-05 0.000340676191418026 1.00660757453666 0.580645161290323 11.3 11 3 increased circulating chloride level 0.001651474809453 0.0144904535750065 1.00548912167607 0.58 11.3 11 3 testicular atrophy 0.001651474809453 0.0144904535750065 1.00548912167607 0.58 11.3 11 3 increased leukocyte cell number 1.34595468130483e-07 3.91586230379621e-06 1.00429353413543 0.579310344827586 11.3 11 3 abnormal blood vessel morphology 1.34595468130483e-07 3.91586230379621e-06 1.00429353413543 0.579310344827586 11.3 11 3 abnormal facial morphology 0.000847864182203725 0.0082152321294985 1.00366427753509 0.578947368421053 11.3 11 3 decreased total retina thickness 0.00601977157991506 0.0410814315638922 1.00366427753509 0.578947368421053 11.3 11 3 kyphoscoliosis 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 flaky skin 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 delayed sexual maturation 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal nasal septum morphology 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal metatarsal bone morphology 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal digestive system development 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal sternebra morphology 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 eyelids fail to open 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 decreased circulating magnesium level 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 thin interventricular septum 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 decreased lymphocyte cell number 8.14269357876434e-07 2.02549502771763e-05 1.00223861804996 0.578125 11.3 11 3 albuminuria 0.00304384990529585 0.0234051828112007 1.00163667293401 0.577777777777778 11.3 11 3 abnormal xiphoid process morphology 0.0228870450515144 0.10990641808039 1.00015496187938 0.576923076923077 11.3 11 3 respiratory failure 1.14023892365677e-07 3.43799311829845e-06 0.998830253320597 0.576158940397351 11.3 11 3 abnormal heart morphology 6.40497859941081e-11 3.42631919699664e-09 0.998134446804874 0.575757575757576 11.3 11 3 neuron degeneration 0.0028548946750699 0.0221923453257387 0.995898983318189 0.574468085106383 11.3 11 3 increased or absent threshold for auditory brainstem response 3.88328020548918e-13 3.11601919714656e-11 0.995771353049918 0.57439446366782 11.3 11 3 diluted coat color 0.00145841629633714 0.0128418072111102 0.995215925030591 0.574074074074074 11.3 11 3 impaired limb coordination 0.00145841629633714 0.0128418072111102 0.995215925030591 0.574074074074074 11.3 11 3 hydroencephaly 4.41528557561405e-06 9.00247776175406e-05 0.994936762078268 0.573913043478261 11.3 11 3 ventricular septal defect 6.48613906881377e-07 1.66332690037879e-05 0.994271697397734 0.573529411764706 11.3 11 3 reduced male fertility 1.70663034518689e-10 8.66319863449505e-09 0.992811680220939 0.572687224669604 11.3 11 3 domed cranium 0.000364209089571594 0.00411804595595154 0.990629676528145 0.571428571428571 11.3 11 3 short mandible 0.00136765413380192 0.0123238645842684 0.990629676528145 0.571428571428571 11.3 11 3 abnormal long bone hypertrophic chondrocyte zone 0.00267366148881424 0.0208821583297937 0.990629676528145 0.571428571428571 11.3 11 3 decreased urine osmolality 0.00267366148881424 0.0208821583297937 0.990629676528145 0.571428571428571 11.3 11 3 abnormal craniofacial development 0.00267366148881424 0.0208821583297937 0.990629676528145 0.571428571428571 11.3 11 3 abnormal optic nerve morphology 0.00526974336469637 0.0361115333875543 0.990629676528145 0.571428571428571 11.3 11 3 abnormal vibrissa morphology 0.00526974336469637 0.0361115333875543 0.990629676528145 0.571428571428571 11.3 11 3 abnormal dermal layer morphology 0.010501822345162 0.0604705626934966 0.990629676528145 0.571428571428571 11.3 11 3 increased bone resorption 0.0212593359109271 0.102585059318004 0.990629676528145 0.571428571428571 11.3 11 3 prolonged QRS complex duration 0.0212593359109271 0.102585059318004 0.990629676528145 0.571428571428571 11.3 11 3 small ears 0.0440850688483312 0.177589649814128 0.990629676528145 0.571428571428571 11.3 11 3 decreased cochlear outer hair cell number 0.0440850688483312 0.177589649814128 0.990629676528145 0.571428571428571 11.3 11 3 abnormal bile salt homeostasis 0.0440850688483312 0.177589649814128 0.990629676528145 0.571428571428571 11.3 11 3 megacephaly 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 translucent skin 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal placing response 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal kidney medulla morphology 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 intestinal obstruction 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal ventral body wall morphology 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 decreased CNS synapse formation 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal iris pigmentation 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 decreased tongue size 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 sternebra fusion 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 increased stomach tumor incidence 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 decreased B cell proliferation 0.000177681873802051 0.00224357188366803 0.987494772488499 0.569620253164557 11.3 11 3 decreased litter size 2.7165091965506e-12 1.85131962367661e-10 0.987104304013811 0.569395017793594 11.3 11 3 abnormal spermiogenesis 0.00128101234553711 0.011650889248715 0.986359721025869 0.568965517241379 11.3 11 3 female infertility 1.50787901485017e-11 8.62264149296507e-10 0.984112376024671 0.567669172932331 11.3 11 3 hypoactivity 9.72142900471113e-16 1.16417077695289e-13 0.984060514216951 0.56763925729443 11.3 11 3 abnormal hair follicle development 0.00977707633398432 0.0565592497227581 0.98393623276782 0.567567567567568 11.3 11 3 increased trabecular bone volume 0.00977707633398432 0.0565592497227581 0.98393623276782 0.567567567567568 11.3 11 3 decreased white adipose tissue amount 0.000618418242754447 0.00640964741188203 0.983236917748085 0.567164179104478 11.3 11 3 liver inflammation 5.8257257128673e-06 0.000116397531813313 0.982374429223744 0.566666666666667 11.3 11 3 abnormal eating behavior 0.00119858255163746 0.0111041865817437 0.982374429223744 0.566666666666667 11.3 11 3 impaired coordination 2.02273149464965e-14 2.14108280550681e-12 0.982040401876167 0.566473988439306 11.3 11 3 increased bone mineral density 1.10642176851588e-05 0.000200161756304237 0.981863042222587 0.566371681415929 11.3 11 3 abnormal placenta development 0.00233616625128936 0.0192424289737824 0.981284113542031 0.566037735849057 11.3 11 3 limb grasping 2.96886786656592e-08 1.04752607348691e-06 0.981104391176913 0.565934065934066 11.3 11 3 abnormal neuron morphology 4.00970905923868e-05 0.000613793925221921 0.980623316159174 0.565656565656566 11.3 11 3 failure of embryo implantation 0.0406148808901742 0.164543186016789 0.97986196265284 0.565217391304348 11.3 11 3 abnormal B cell morphology 0.0406148808901742 0.164543186016789 0.97986196265284 0.565217391304348 11.3 11 3 abnormal palatal shelf fusion at midline 0.0406148808901742 0.164543186016789 0.97986196265284 0.565217391304348 11.3 11 3 decreased neutrophil cell number 9.74324866636967e-06 0.000180195769944941 0.977929296059836 0.564102564102564 11.3 11 3 small lens 0.00909039843384789 0.0534813193603255 0.977929296059836 0.564102564102564 11.3 11 3 acanthosis 0.00909039843384789 0.0534813193603255 0.977929296059836 0.564102564102564 11.3 11 3 decreased B-1 B cell number 0.00909039843384789 0.0534813193603255 0.977929296059836 0.564102564102564 11.3 11 3 abnormal ovary morphology 0.000541278252846321 0.00572948788917116 0.976677145872819 0.563380281690141 11.3 11 3 abnormal lung morphology 9.13596923258719e-06 0.000169594951239258 0.97606159304979 0.563025210084034 11.3 11 3 scoliosis 0.0182557151781043 0.088780237547477 0.975151087832393 0.5625 11.3 11 3 polydipsia 0.0182557151781043 0.088780237547477 0.975151087832393 0.5625 11.3 11 3 increased circulating follicle stimulating hormone level 0.0182557151781043 0.088780237547477 0.975151087832393 0.5625 11.3 11 3 abnormal tympanic ring morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased mast cell number 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 delayed hair appearance 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal pituitary gland morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal intestinal absorption 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal olfaction 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 white spotting 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 impaired muscle relaxation 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal pulmonary elastic fiber morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased aggression towards mice 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 small pancreas 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 bowed tibia 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 increased cochlear outer hair cell number 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 small epididymis 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal amnion morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased skeletal muscle weight 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 dilated respiratory conducting tubes 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal pulmonary alveolus wall morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased adipocyte glucose uptake 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal muscle physiology 0.000128356839222613 0.00168046125034868 0.973933670743963 0.561797752808989 11.3 11 3 neonatal lethality, incomplete penetrance 9.50522828576901e-11 4.9258865335105e-09 0.973484162895927 0.561538461538462 11.3 11 3 absent vitelline blood vessels 0.00203298527184762 0.0172301562648073 0.97325020851888 0.56140350877193 11.3 11 3 increased tumor growth/size 0.00844270750990064 0.0517909616051241 0.972508401957509 0.560975609756098 11.3 11 3 abnormal cholesterol homeostasis 0.00844270750990064 0.0517909616051241 0.972508401957509 0.560975609756098 11.3 11 3 infertility 3.08925439788032e-05 0.000494181370722012 0.972113233976218 0.560747663551402 11.3 11 3 increased monocyte cell number 5.88176129143036e-05 0.000863178832591918 0.970817082997583 0.56 11.3 11 3 decreased double-positive T cell number 5.88176129143036e-05 0.000863178832591918 0.970817082997583 0.56 11.3 11 3 abnormal axon extension 0.00397462635345582 0.0296903395021662 0.970817082997583 0.56 11.3 11 3 abnormal circulating protein level 0.00397462635345582 0.0296903395021662 0.970817082997583 0.56 11.3 11 3 decreased respiratory quotient 0.00397462635345582 0.0296903395021662 0.970817082997583 0.56 11.3 11 3 mandible hypoplasia 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 increased cellular sensitivity to ionizing radiation 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 abnormal cochlear outer hair cell morphology 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 increased liver glycogen level 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 abnormal colon morphology 0.00189412943954625 0.0163598853502475 0.969641759652549 0.559322033898305 11.3 11 3 increased hemoglobin content 0.00189412943954625 0.0163598853502475 0.969641759652549 0.559322033898305 11.3 11 3 impaired balance 5.49936990724806e-05 0.000811850602034395 0.968777551310613 0.558823529411765 11.3 11 3 short maxilla 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 abnormal oocyte morphology 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 abnormal spleen red pulp morphology 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 increased susceptibility to weight gain 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 abnormal male reproductive system morphology 0.00783397913093014 0.0491750062373935 0.967591777074003 0.558139534883721 11.3 11 3 abnormal left-right axis patterning 0.00783397913093014 0.0491750062373935 0.967591777074003 0.558139534883721 11.3 11 3 decreased cardiac muscle contractility 5.13941716319212e-05 0.000767825837443867 0.966816463150065 0.557692307692308 11.3 11 3 decreased kidney weight 0.00369538230773247 0.0279400106093754 0.966816463150065 0.557692307692308 11.3 11 3 abnormal female meiosis 0.00369538230773247 0.0279400106093754 0.966816463150065 0.557692307692308 11.3 11 3 thick epidermis 0.000848769711469795 0.0082152321294985 0.965863934614942 0.557142857142857 11.3 11 3 improved glucose tolerance 4.27605386613436e-08 1.39956368315911e-06 0.964094953049713 0.556122448979592 11.3 11 3 abnormal small intestine morphology 0.0034333536949796 0.0262184260565321 0.963112185513475 0.555555555555556 11.3 11 3 abnormal neuronal precursor proliferation 0.0034333536949796 0.0262184260565321 0.963112185513475 0.555555555555556 11.3 11 3 axon degeneration 0.0034333536949796 0.0262184260565321 0.963112185513475 0.555555555555556 11.3 11 3 irregular heartbeat 0.00726352737161865 0.0467477990605469 0.963112185513475 0.555555555555556 11.3 11 3 decreased osteoclast cell number 0.00726352737161865 0.0467477990605469 0.963112185513475 0.555555555555556 11.3 11 3 lethality at weaning, complete penetrance 0.00726352737161865 0.0467477990605469 0.963112185513475 0.555555555555556 11.3 11 3 rectal prolapse 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal trigeminal nerve morphology 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 increased brain weight 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal brain commissure morphology 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 cryptorchism 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal skin appearance 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 decreased bone ossification 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal neuromuscular synapse morphology 0.000790593634107588 0.00778698143027895 0.963112185513475 0.555555555555556 11.3 11 3 abnormal pharyngeal arch morphology 0.0156095905896484 0.0842274546458795 0.963112185513475 0.555555555555556 11.3 11 3 abnormal retinal blood vessel morphology 0.0156095905896484 0.0842274546458795 0.963112185513475 0.555555555555556 11.3 11 3 abnormal heart shape 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal stomach glandular epithelium morphology 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 cortical renal glomerulopathies 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 delayed kidney development 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 absent spleen 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 eye inflammation 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thyroid cartilage morphology 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thymus cortex morphology 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 acidosis 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal pregnancy 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 heart hyperplasia 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal head movements 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 thick tail 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal cholinergic neuron morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal germ cell morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 long gestation period 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thymus lobule morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal gut-associated lymphoid tissue morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 yellow coat color 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal abdominal wall morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal ovary physiology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thymus physiology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal stria vascularis vasculature morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal optic chiasm morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 multiflagellated sperm 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal hyoid bone lesser horn morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal ventricle myocardium morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 prolonged RR interval 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 fusion of atlas and occipital bones 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal heart left ventricle pressure 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 decreased bone trabecular spacing 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 male infertility 3.33238495253782e-18 5.52620504629188e-16 0.961580396749239 0.554671968190855 11.3 11 3 abnormal pulmonary alveolus morphology 8.52242153433186e-05 0.0011648089871786 0.961205032670874 0.554455445544555 11.3 11 3 weight loss 2.83925725734054e-07 7.76115651388418e-06 0.960910786232301 0.554285714285714 11.3 11 3 postnatal lethality 5.71464063615532e-07 1.48074672733712e-05 0.960791433259225 0.55421686746988 11.3 11 3 abnormal neuron differentiation 3.90393312763123e-05 0.000606939603436417 0.959672499136641 0.553571428571429 11.3 11 3 increased bone marrow cell number 0.0144184527948935 0.0792016295406067 0.958043174010772 0.552631578947368 11.3 11 3 decreased neuron apoptosis 0.0144184527948935 0.0792016295406067 0.958043174010772 0.552631578947368 11.3 11 3 abnormal retinal outer nuclear layer morphology 0.0144184527948935 0.0792016295406067 0.958043174010772 0.552631578947368 11.3 11 3 maternal effect 0.00141821353190113 0.0126899502180002 0.957362262017872 0.552238805970149 11.3 11 3 focal hair loss 0.0315822649502185 0.135198032048925 0.956470032509934 0.551724137931034 11.3 11 3 stomach inflammation 0.0315822649502185 0.135198032048925 0.956470032509934 0.551724137931034 11.3 11 3 short sternum 0.0315822649502185 0.135198032048925 0.956470032509934 0.551724137931034 11.3 11 3 lung inflammation 7.70867141562297e-06 0.000144719397331035 0.956030478267052 0.551470588235294 11.3 11 3 increased urine protein level 0.000637024226398097 0.00656148142097419 0.955703630240294 0.551282051282051 11.3 11 3 absent gastric milk in neonates 0.000637024226398097 0.00656148142097419 0.955703630240294 0.551282051282051 11.3 11 3 cardiac hypertrophy 0.000140825358890444 0.00179642605251271 0.955250045223569 0.551020408163265 11.3 11 3 neonatal lethality, complete penetrance 5.51348128606273e-16 6.85739234954052e-14 0.954241415383746 0.550438596491228 11.3 11 3 abnormal skin pigmentation 0.0133111472963088 0.0738271547370525 0.95348106365834 0.55 11.3 11 3 increased susceptibility to weight loss 0.0133111472963088 0.0738271547370525 0.95348106365834 0.55 11.3 11 3 abnormal cell proliferation 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal vascular regression 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal fibula morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal Peyer's patch T cell area morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal hyoid bone morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal heart right ventricle morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal incus morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 decreased circulating VLDL cholesterol level 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal heart electrocardiography waveform feature 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 ataxia 7.62349709805866e-08 2.38533950080766e-06 0.95262284487917 0.54950495049505 11.3 11 3 postnatal lethality, complete penetrance 1.33250196145827e-13 1.14296504452671e-11 0.952133704642337 0.549222797927461 11.3 11 3 increased lung adenocarcinoma incidence 0.00576902149496986 0.0394785171079437 0.951781453919199 0.549019607843137 11.3 11 3 sparse hair 0.000550459866977809 0.00581430538899066 0.951366914958432 0.548780487804878 11.3 11 3 abnormal cranial ganglia morphology 0.0290136048156001 0.131579474892991 0.950684931506849 0.548387096774194 11.3 11 3 abnormal object recognition memory 0.0290136048156001 0.131579474892991 0.950684931506849 0.548387096774194 11.3 11 3 cachexia 0.000113538172291819 0.00151842044933279 0.950147213785409 0.548076923076923 11.3 11 3 abnormal cartilage morphology 0.0122836641067268 0.0684336270223584 0.949353440006139 0.547619047619048 11.3 11 3 skin edema 0.0122836641067268 0.0684336270223584 0.949353440006139 0.547619047619048 11.3 11 3 cyanosis 2.3226396508561e-07 6.49164733876915e-06 0.948063557614827 0.546875 11.3 11 3 abnormal neurocranium morphology 0.00105397579850901 0.00996868744787518 0.947702390545259 0.546666666666667 11.3 11 3 abnormal joint morphology 0.00493703499513288 0.0340202648499215 0.945601054867775 0.545454545454545 11.3 11 3 increased T cell number 0.000441069194362012 0.00476352984922531 0.945601054867775 0.545454545454545 11.3 11 3 abnormal skin morphology 0.00218506419096842 0.0183626593751147 0.945601054867775 0.545454545454545 11.3 11 3 abnormal gametogenesis 0.0113316395529858 0.0646945807988785 0.945601054867775 0.545454545454545 11.3 11 3 abnormal T cell subpopulation ratio 0.0266477070756604 0.124832714408108 0.945601054867775 0.545454545454545 11.3 11 3 abnormal middle ear ossicle morphology 0.0266477070756604 0.124832714408108 0.945601054867775 0.545454545454545 11.3 11 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0266477070756604 0.124832714408108 0.945601054867775 0.545454545454545 11.3 11 3 abnormal chorion morphology 0.0653900873484109 0.218295389972812 0.945601054867775 0.545454545454545 11.3 11 3 abnormal tracheal cartilage morphology 0.0653900873484109 0.218295389972812 0.945601054867775 0.545454545454545 11.3 11 3 abnormal retinal outer plexiform layer morphology 0.0653900873484109 0.218295389972812 0.945601054867775 0.545454545454545 11.3 11 3 abnormal ear position 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal sphenoid bone morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal awl hair morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 enlarged cranium 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal large intestine morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 impaired myelopoiesis 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal fear/anxiety-related behavior 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal larynx morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 allodynia 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal frequency of paradoxical sleep 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 dilated renal glomerular capsule 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 pathological neovascularization 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal pituitary gland development 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal spinal cord ventral horn morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 cyclopia 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 chylous ascites 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 decreased colon length 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal locomotor behavior 0.000379987123915578 0.00427700439248869 0.942174964089269 0.543478260869565 11.3 11 3 respiratory distress 1.41527313940917e-06 3.33695917941262e-05 0.941957120166936 0.543352601156069 11.3 11 3 abnormal midbrain development 0.0244714097906789 0.117265992039873 0.941098192701738 0.542857142857143 11.3 11 3 abnormal lipid level 0.000779372457657678 0.00778222259183772 0.939904662970981 0.542168674698795 11.3 11 3 curly vibrissae 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 abnormal vasodilation 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 small lymph nodes 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 hypopigmentation 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 increased circulating total protein level 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 abnormal cardiovascular system physiology 2.69521306107291e-05 0.00043676498302403 0.938491272500348 0.541353383458647 11.3 11 3 increased osteoclast cell number 0.0039001078922538 0.0293097232084028 0.937850226549187 0.540983606557377 11.3 11 3 abnormal branching of the mammary ductal tree 0.0224713720669003 0.108119029045289 0.937082126445543 0.540540540540541 11.3 11 3 decreased circulating chloride level 0.0224713720669003 0.108119029045289 0.937082126445543 0.540540540540541 11.3 11 3 decreased T cell number 4.5966189707263e-06 9.33395076708709e-05 0.936791107151616 0.540372670807453 11.3 11 3 increased body length 0.00888323824263013 0.0534813193603255 0.936145044319098 0.54 11.3 11 3 abnormal nervous system physiology 0.000110391462571962 0.00148431763863652 0.934637564376555 0.539130434782609 11.3 11 3 small ovary 0.000574326505537708 0.00605354738358072 0.933477964420752 0.538461538461538 11.3 11 3 abnormal snout morphology 0.00818826721341345 0.0506674494859849 0.933477964420752 0.538461538461538 11.3 11 3 abnormal skin condition 0.00818826721341345 0.0506674494859849 0.933477964420752 0.538461538461538 11.3 11 3 increased susceptibility to injury 0.00818826721341345 0.0506674494859849 0.933477964420752 0.538461538461538 11.3 11 3 abnormal lens fiber morphology 0.0206345162161134 0.099763574514251 0.933477964420752 0.538461538461538 11.3 11 3 increased vascular permeability 0.0206345162161134 0.099763574514251 0.933477964420752 0.538461538461538 11.3 11 3 short hair 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 excessive scratching 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 lymphoid hypoplasia 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 dystrophic cardiac calcinosis 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 abnormal soleus morphology 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 abnormal GABAergic neuron morphology 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 orthokeratosis 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 empty decidua capsularis 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 abnormal aorta tunica media morphology 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 decreased cardiac stroke volume 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 increased circulating triglyceride level 1.72752760775888e-05 0.000299458182878064 0.932558281697185 0.537931034482759 11.3 11 3 increased cell proliferation 0.00754688940584231 0.0485087529639089 0.931008445996359 0.537037037037037 11.3 11 3 scaly skin 0.0189482881016234 0.0919685202981235 0.930225427959356 0.536585365853659 11.3 11 3 short humerus 0.0189482881016234 0.0919685202981235 0.930225427959356 0.536585365853659 11.3 11 3 abnormal epidermal layer morphology 0.00284073002775318 0.0221167948170142 0.929612631234745 0.536231884057971 11.3 11 3 abnormal coat appearance 0.00284073002775318 0.0221167948170142 0.929612631234745 0.536231884057971 11.3 11 3 increased food intake 0.00108853962946764 0.0101986528372909 0.928715321745136 0.535714285714286 11.3 11 3 abnormal circulating cholesterol level 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 shortened head 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 abnormal ovulation 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 straub tail 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 abnormal retinal inner nuclear layer morphology 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 abnormal skeletal muscle fiber morphology 0.00262352124982538 0.0208821583297937 0.927843288579178 0.535211267605634 11.3 11 3 decreased oxygen consumption 0.0174008018288931 0.0873209883788731 0.927275453029253 0.534883720930233 11.3 11 3 abnormal enzyme/coenzyme level 0.00640955825410211 0.0428203811863781 0.926580343993998 0.53448275862069 11.3 11 3 increased liver weight 0.000930887188653399 0.00890608416067435 0.925901032891363 0.534090909090909 11.3 11 3 abnormal eye physiology 0.00590648437152876 0.0403636809730159 0.924587698092936 0.533333333333333 11.3 11 3 emphysema 0.045146519309143 0.181424825172041 0.924587698092936 0.533333333333333 11.3 11 3 disorganized myocardium 0.045146519309143 0.181424825172041 0.924587698092936 0.533333333333333 11.3 11 3 abnormal microglial cell physiology 0.045146519309143 0.181424825172041 0.924587698092936 0.533333333333333 11.3 11 3 no suckling reflex 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 audiogenic seizures 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal seizure response to electrical stimulation 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 arthritis 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal pericyte morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal zygomatic bone morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal cerebral aqueduct morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal Muller cell morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 liver vascular congestion 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal autopod morphology 0.0159809106174053 0.0861376276506947 0.924587698092936 0.533333333333333 11.3 11 3 neonatal lethality 0.0412058797380957 0.166551805976071 0.92097602739726 0.53125 11.3 11 3 hyperactivity 5.4389616682339e-11 2.94117764124605e-09 0.920537954132286 0.53099730458221 11.3 11 3 decreased heart rate 0.000581081429527617 0.00608606339347346 0.918809024979855 0.53 11.3 11 3 distended abdomen 0.012386732083748 0.068930639951506 0.91778925913637 0.529411764705882 11.3 11 3 overexpanded pulmonary alveoli 0.0376274681397767 0.153188751223722 0.91778925913637 0.529411764705882 11.3 11 3 abnormal adipose tissue morphology 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal bone marrow cavity morphology 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 hydroureter 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 distended urinary bladder 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal heart rate 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal cranial suture morphology 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 decreased vasoconstriction 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 increased regulatory T cell number 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 increased circulating magnesium level 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal circulating chemokine level 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 common atrium 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 increased trabecular bone mass 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal electroretinogram waveform feature 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 delayed heart development 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 decreased body fat mass 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 dehydration 0.00392438444088879 0.0294476811363827 0.916332450788535 0.528571428571429 11.3 11 3 no abnormal phenotype detected 1.12543402623769e-45 9.33172380088755e-43 0.916261079774376 0.528530259365994 11.3 11 3 renal hypoplasia 0.0343757959565364 0.140641105989941 0.914956576237801 0.527777777777778 11.3 11 3 short radius 0.0343757959565364 0.140641105989941 0.914956576237801 0.527777777777778 11.3 11 3 abnormal locomotor activation 0.00118042082049135 0.0109563313095978 0.914427393718288 0.527472527472527 11.3 11 3 abnormal contextual conditioning behavior 0.0104578808639414 0.0602873201600327 0.914081019705516 0.527272727272727 11.3 11 3 seizures 0.000334609141456201 0.00382685167527494 0.91242207048645 0.526315789473684 11.3 11 3 short vibrissae 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal stationary movement 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 increased malignant tumor incidence 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal neurotransmitter level 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 increased susceptibility to ischemic brain injury 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 oliguria 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal photoreceptor inner segment morphology 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 increased circulating VLDL cholesterol level 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 Leydig cell hypoplasia 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 shortened RR interval 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 right-sided stomach 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal male meiosis 0.00812041703831485 0.0504357987086347 0.909430522714363 0.524590163934426 11.3 11 3 abnormal response/metabolism to endogenous compounds 0.00240428887388792 0.0195127849063498 0.90908394096028 0.524390243902439 11.3 11 3 decreased B cell number 2.39973303702201e-06 5.2133938249714e-05 0.908878683804949 0.524271844660194 11.3 11 3 decreased exploration in new environment 0.00221603975325052 0.0185915645403395 0.908077203484133 0.523809523809524 11.3 11 3 abnormal spleen white pulp morphology 0.0262793744960097 0.123697980788985 0.908077203484133 0.523809523809524 11.3 11 3 abnormal associative learning 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 increased keratinocyte proliferation 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 complete atrioventricular septal defect 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 increased bone ossification 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 increased circulating cholesterol level 1.49853681008432e-05 0.000260672050005925 0.906201010914951 0.522727272727273 11.3 11 3 insulin resistance 0.000164328904939783 0.00208555179100872 0.906201010914951 0.522727272727273 11.3 11 3 hyperglycemia 0.00188284352925186 0.0163190706585854 0.906201010914951 0.522727272727273 11.3 11 3 lethality, incomplete penetrance 0.0240479795596487 0.115370008012779 0.906201010914951 0.522727272727273 11.3 11 3 rib fusion 0.00631247707213087 0.0428203811863781 0.905612950557447 0.522388059701492 11.3 11 3 increased sensitivity to induced morbidity/mortality 1.09701678244263e-05 0.000199914230500077 0.904487965525698 0.521739130434783 11.3 11 3 abnormal inner ear morphology 0.0220140194008574 0.106123785386885 0.904487965525698 0.521739130434783 11.3 11 3 abnormal blood vessel physiology 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal carpal bone morphology 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 blistering 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal postnatal growth 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal nasal cavity morphology 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal cardiovascular development 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal cardiovascular system morphology 0.0201590182330751 0.097654445676289 0.902917673918883 0.520833333333333 11.3 11 3 obese 0.0041584865251252 0.0306950600333796 0.900572433207405 0.519480519480519 11.3 11 3 abnormal hair growth 0.0169210741437094 0.0873209883788731 0.90013946569144 0.519230769230769 11.3 11 3 abnormal brain wave pattern 0.0169210741437094 0.0873209883788731 0.90013946569144 0.519230769230769 11.3 11 3 wrinkled skin 0.0757199650018003 0.243982533040378 0.898904706479243 0.518518518518518 11.3 11 3 increased body weight 2.29986326890531e-06 5.04748360393878e-05 0.897758144353632 0.517857142857143 11.3 11 3 aphagia 0.0686746733000161 0.223660344829092 0.896690655478063 0.517241379310345 11.3 11 3 increased retinal apoptosis 0.0686746733000161 0.223660344829092 0.896690655478063 0.517241379310345 11.3 11 3 increased lung adenoma incidence 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 decreased thymus weight 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 abnormal CD8-positive, alpha beta T cell morphology 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 decreased double-negative T cell number 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 abnormal vascular development 0.00924751555928944 0.0536205010576515 0.893067662930677 0.515151515151515 11.3 11 3 abnormal tooth development 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 abnormal ovarian folliculogenesis 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 decreased systemic arterial blood pressure 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 dilated heart atrium 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 abnormal gait 6.03603160649582e-08 1.94843793007925e-06 0.89204759706782 0.514563106796116 11.3 11 3 increased circulating HDL cholesterol level 0.00130992620336483 0.0118921220104745 0.891566708875331 0.514285714285714 11.3 11 3 abnormal artery morphology 0.0515574122741155 0.191574221702289 0.891566708875331 0.514285714285714 11.3 11 3 abnormal intestinal goblet cell morphology 0.0515574122741155 0.191574221702289 0.891566708875331 0.514285714285714 11.3 11 3 abnormal breathing pattern 0.0469415767289304 0.183229627327891 0.890228020123266 0.513513513513513 11.3 11 3 decreased startle reflex 0.000802360178122261 0.00779637087140283 0.889026632781669 0.512820512820513 11.3 11 3 increased B cell number 0.000802360178122261 0.00779637087140283 0.889026632781669 0.512820512820513 11.3 11 3 abnormal posture 0.00510730440027438 0.0351436229479461 0.88847099113618 0.5125 11.3 11 3 cardiomyopathy 0.0324817334538122 0.137877691381777 0.886063210672397 0.511111111111111 11.3 11 3 increased macrophage cell number 0.0189936485476322 0.0920988318951952 0.882008001470235 0.508771929824561 11.3 11 3 syndactyly 0.0173934504400243 0.0873209883788731 0.881492508775045 0.508474576271186 11.3 11 3 skin lesions 0.0146008070488554 0.0792016295406067 0.880559712469463 0.507936507936508 11.3 11 3 abnormal femur morphology 0.0122714946066649 0.0684336270223584 0.879738294827234 0.507462686567164 11.3 11 3 decreased spleen weight 0.0112548309754379 0.0645822192650559 0.879363299816651 0.507246376811594 11.3 11 3 abnormal dendritic cell physiology 0.00226075875125389 0.0188672273401631 0.874901910578596 0.504672897196262 11.3 11 3 increased anxiety-related response 0.000606181857035146 0.00633561919905431 0.873036945141711 0.503597122302158 11.3 11 3 abnormal phalanx morphology 0.0391784926713554 0.159372854488956 0.866800966962127 0.5 11.3 11 3 abnormal frontal bone morphology 0.0624640933109529 0.218295389972812 0.866800966962127 0.5 11.3 11 3 abnormal reproductive system physiology 0.0624640933109529 0.218295389972812 0.866800966962127 0.5 11.3 11 3 increased metastatic potential 0.0922028272908891 0.287002176580327 0.866800966962127 0.5 11.3 11 3 abnormal response to new environment 0.0922028272908891 0.287002176580327 0.866800966962127 0.5 11.3 11 3 salivary gland inflammation 0.0922028272908891 0.287002176580327 0.866800966962127 0.5 11.3 11 3 rib bifurcation 0.101950985160376 0.313283601712706 0.866800966962127 0.5 11.3 11 3 abnormal respiration 0.101950985160376 0.313283601712706 0.866800966962127 0.5 11.3 11 3 abnormal spleen germinal center morphology 0.101950985160376 0.313283601712706 0.866800966962127 0.5 11.3 11 3 abnormal leukocyte cell number 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 abnormal stomach morphology 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 increased susceptibility to otitis media 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 decreased Peyer's patch number 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 abnormal malleus morphology 0.125275422917841 0.339666734471754 0.866800966962127 0.5 11.3 11 3 abnormal sensory capabilities/reflexes/nociception 0.125275422917841 0.339666734471754 0.866800966962127 0.5 11.3 11 3 prolonged QT interval 0.125275422917841 0.339666734471754 0.866800966962127 0.5 11.3 11 3 abnormal interparietal bone morphology 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal vasoconstriction 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 increased aggression towards males 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal pinna reflex 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal antigen presentation 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 absent otoliths 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal voluntary movement 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal vascular endothelial cell migration 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal uterus development 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal hair cuticle 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 vascular smooth muscle hypoplasia 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal pancreas development 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 premature hair loss 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 increased circulating growth hormone level 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 decreased cornea thickness 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal esophagus morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased papilloma incidence 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 altered tumor susceptibility 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased growth rate 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased circulating parathyroid hormone level 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 decreased synaptic depression 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal alisphenoid bone morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased fear-related response 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal nucleotide metabolism 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 small parietal bone 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal cochlear outer hair cell physiology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal B cell proliferation 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 decreased keratinocyte proliferation 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal aorta elastic tissue morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased skeletal muscle glycogen level 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 persistent right dorsal aorta 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal respiratory motile cilium morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 teratozoospermia 0.00679153573465865 0.0441095173367191 0.866800966962127 0.5 11.3 11 3 abnormal inflammatory response 0.0134879750565232 0.0747245834144799 0.866800966962127 0.5 11.3 11 3 cochlear ganglion degeneration 0.0249462308314906 0.118763156350876 0.866800966962127 0.5 11.3 11 3 abnormal digestive system physiology 0.035759767781452 0.146183109870767 0.866800966962127 0.5 11.3 11 3 hypertension 0.0471134931158533 0.183229627327891 0.866800966962127 0.5 11.3 11 3 abnormal pancreatic beta cell morphology 0.0568136572311693 0.207524188491239 0.866800966962127 0.5 11.3 11 3 abnormal epidermis stratum granulosum morphology 0.0687390285916948 0.223660344829092 0.866800966962127 0.5 11.3 11 3 impaired wound healing 0.0687390285916948 0.223660344829092 0.866800966962127 0.5 11.3 11 3 abnormal bone remodeling 0.0757204082440893 0.243982533040378 0.866800966962127 0.5 11.3 11 3 abnormal heart atrium morphology 0.0835040431330815 0.265961981169706 0.866800966962127 0.5 11.3 11 3 abnormal depression-related behavior 0.0835040431330815 0.265961981169706 0.866800966962127 0.5 11.3 11 3 intestinal ulcer 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 increased skin papilloma incidence 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 increased coping response 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 abnormal retinal layer morphology 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 failure of palatal shelf elevation 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 waved hair 0.155258204915592 0.370105208172051 0.866800966962127 0.5 11.3 11 3 abnormal hearing physiology 0.155258204915592 0.370105208172051 0.866800966962127 0.5 11.3 11 3 decreased muscle cell glucose uptake 0.155258204915592 0.370105208172051 0.866800966962127 0.5 11.3 11 3 underdeveloped hair follicles 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal Peyer's patch follicle morphology 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal white adipose tissue morphology 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 decreased activity of thyroid 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 decreased heart rate variability 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal neutrophil morphology 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 decreased pulmonary respiratory rate 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal mouth morphology 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal meiosis 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 paternal imprinting 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 bowed radius 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal epididymis epithelium morphology 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 sepsis 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal thoracic cage shape 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal lateral semicircular canal morphology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 kidney hemorrhage 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal grooming behavior 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 absent trophoblast giant cells 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal immune cell physiology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 rhinitis 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal neuron specification 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 delayed dark adaptation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 intestinal edema 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 peritoneal inflammation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal hypaxial muscle morphology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 lymphedema 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal glial cell physiology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased left ventricle diastolic pressure 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased heart rate variability 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal reproductive system development 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal cochlear inner hair cell physiology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 absent coat pigmentation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 ascites 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased susceptibility to atherosclerosis 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased platelet aggregation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased serotonin level 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased compact bone area 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal circadian temperature homeostasis 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 decreased anxiety-related response 0.00210332603852305 0.0177056633530493 0.859753804629102 0.495934959349593 11.3 11 3 abnormal trabecular bone morphology 0.0024821920175876 0.0199497662156677 0.85951692522295 0.495798319327731 11.3 11 3 increased thermal nociceptive threshold 0.00802741242638317 0.0499824189268433 0.857275681610895 0.494505494505495 11.3 11 3 abnormal B cell differentiation 0.00802741242638317 0.0499824189268433 0.857275681610895 0.494505494505495 11.3 11 3 increased startle reflex 0.00873985821996378 0.0528461778156897 0.857061630254688 0.49438202247191 11.3 11 3 decreased compact bone thickness 0.0226137145031928 0.108698772611965 0.853863639097021 0.492537313432836 11.3 11 3 impaired hematopoiesis 0.0463084212458555 0.183229627327891 0.849804869570713 0.490196078431373 11.3 11 3 abnormal response to novel object 0.0463084212458555 0.183229627327891 0.849804869570713 0.490196078431373 11.3 11 3 abnormal innervation 0.055676777392379 0.204120830896894 0.848358393196976 0.48936170212766 11.3 11 3 decreased bone trabecula number 0.055676777392379 0.204120830896894 0.848358393196976 0.48936170212766 11.3 11 3 decreased insulin secretion 0.0111317341741754 0.0639496276172319 0.847538723251858 0.488888888888889 11.3 11 3 abnormal cartilage development 0.061109089314327 0.218295389972812 0.847538723251858 0.488888888888889 11.3 11 3 short femur 0.0121221284097445 0.0677613357735715 0.847100944985715 0.488636363636364 11.3 11 3 arrest of spermatogenesis 0.0143840518969417 0.0792016295406067 0.846162848701124 0.488095238095238 11.3 11 3 short ulna 0.0737806946449238 0.238195299064566 0.845659479963051 0.48780487804878 11.3 11 3 abnormal circulating hormone level 0.0811723308860012 0.259199195223271 0.844575301142586 0.487179487179487 11.3 11 3 decreased trabecular bone volume 0.0811723308860012 0.259199195223271 0.844575301142586 0.487179487179487 11.3 11 3 increased brown adipose tissue amount 0.0893892461458925 0.279341394205914 0.843373913800989 0.486486486486487 11.3 11 3 impaired skeletal muscle contractility 0.0893892461458925 0.279341394205914 0.843373913800989 0.486486486486487 11.3 11 3 abnormal calcium ion homeostasis 0.0893892461458925 0.279341394205914 0.843373913800989 0.486486486486487 11.3 11 3 abnormal humoral immune response 0.00777836570475767 0.0491750062373935 0.842035225048924 0.485714285714286 11.3 11 3 abnormal motor capabilities/coordination/movement 0.00331957509226209 0.0254859353148208 0.840534270993578 0.484848484848485 11.3 11 3 abnormal motor coordination/ balance 0.0100083238385413 0.0577626578848525 0.840534270993578 0.484848484848485 11.3 11 3 deafness 0.0100083238385413 0.0577626578848525 0.840534270993578 0.484848484848485 11.3 11 3 abnormal skeleton physiology 0.108755906607104 0.328114393796447 0.840534270993578 0.484848484848485 11.3 11 3 abnormal locomotor coordination 0.108755906607104 0.328114393796447 0.840534270993578 0.484848484848485 11.3 11 3 cardiovascular system phenotype 0.108755906607104 0.328114393796447 0.840534270993578 0.484848484848485 11.3 11 3 decreased IgM level 0.0108889588685272 0.0626272489837257 0.839992689633402 0.484536082474227 11.3 11 3 absent mature ovarian follicles 0.120185201530234 0.339666734471754 0.83883964544722 0.483870967741935 11.3 11 3 abnormal microglial cell morphology 0.133008876230046 0.339666734471754 0.836911278446192 0.482758620689655 11.3 11 3 decreased granulocyte number 0.133008876230046 0.339666734471754 0.836911278446192 0.482758620689655 11.3 11 3 absent long term depression 0.133008876230046 0.339666734471754 0.836911278446192 0.482758620689655 11.3 11 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00824197463555724 0.0509364270955245 0.835280931799868 0.481818181818182 11.3 11 3 abnormal cochlea morphology 0.0538136775149352 0.199495563067662 0.834697227445012 0.481481481481481 11.3 11 3 increased circulating insulin level 0.00178700078371102 0.0155154082006323 0.834295930701047 0.48125 11.3 11 3 decreased body temperature 0.0589483833130958 0.215163761542665 0.833462468232815 0.480769230769231 11.3 11 3 abnormal feces composition 0.163751078433022 0.387380701476122 0.832128928283642 0.48 11.3 11 3 abnormal energy expenditure 0.163751078433022 0.387380701476122 0.832128928283642 0.48 11.3 11 3 abnormal intestinal epithelium morphology 0.0708551993357211 0.230244687586684 0.830684260005372 0.479166666666667 11.3 11 3 cleft secondary palate 0.0161134196126415 0.0863839036345814 0.829915819431824 0.478723404255319 11.3 11 3 abnormal spatial learning 0.00203989604927236 0.0172593245665476 0.829576385558846 0.478527607361963 11.3 11 3 abnormal sleep pattern 0.0777554276379236 0.250377509707877 0.829113968398557 0.478260869565217 11.3 11 3 abnormal cranial nerve morphology 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 conjunctivitis 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 pancreas inflammation 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 abnormal basicranium morphology 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 increased total body fat amount 0.00512975270795293 0.0352493366326876 0.827988983366808 0.477611940298507 11.3 11 3 abnormal circadian rhythm 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 abnormal photoreceptor outer segment morphology 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 cochlear hair cell degeneration 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 decreased sensitivity to induced morbidity/mortality 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 increased T cell proliferation 0.0120913821037926 0.0676654960251608 0.826296248879785 0.476635514018692 11.3 11 3 increased incidence of induced tumors 0.20336557954916 0.464742194881521 0.825524730440121 0.476190476190476 11.3 11 3 dry skin 0.20336557954916 0.464742194881521 0.825524730440121 0.476190476190476 11.3 11 3 abnormal stapes morphology 0.20336557954916 0.464742194881521 0.825524730440121 0.476190476190476 11.3 11 3 abnormal maternal nurturing 0.0515482335958021 0.191574221702289 0.824171411209892 0.475409836065574 11.3 11 3 abnormal female reproductive system morphology 0.10321113085942 0.315984846784994 0.823460918614021 0.475 11.3 11 3 impaired ovarian folliculogenesis 0.10321113085942 0.315984846784994 0.823460918614021 0.475 11.3 11 3 abnormal compact bone morphology 0.113621883697338 0.338343220318087 0.821179863437805 0.473684210526316 11.3 11 3 enlarged adrenal glands 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 shiny skin 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 stereotypic behavior 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 abnormal cochlear inner hair cell morphology 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 reduced long term potentiation 0.0126302808086792 0.0702074268415408 0.820365200874871 0.473214285714286 11.3 11 3 decreased circulating calcium level 0.067449018899894 0.220038602640638 0.819520914218739 0.472727272727273 11.3 11 3 abnormal learning/memory/conditioning 0.067449018899894 0.220038602640638 0.819520914218739 0.472727272727273 11.3 11 3 abnormal heart left ventricle morphology 0.0412445879321648 0.166551805976071 0.818645357686454 0.472222222222222 11.3 11 3 cochlear outer hair cell degeneration 0.0412445879321648 0.166551805976071 0.818645357686454 0.472222222222222 11.3 11 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.0412445879321648 0.166551805976071 0.818645357686454 0.472222222222222 11.3 11 3 head tilt 0.125205951247763 0.339666734471754 0.818645357686454 0.472222222222222 11.3 11 3 abnormal thrombosis 0.0808759519340223 0.258584743490849 0.815812674787885 0.470588235294118 11.3 11 3 impaired synaptic plasticity 0.138120794040895 0.339666734471754 0.815812674787884 0.470588235294118 11.3 11 3 decreased pancreatic beta cell number 0.138120794040895 0.339666734471754 0.815812674787884 0.470588235294118 11.3 11 3 enhanced behavioral response to cocaine 0.255627404345269 0.547616442895411 0.815812674787884 0.470588235294118 11.3 11 3 organ of Corti degeneration 0.0886305670100707 0.277493436674073 0.813731520005262 0.469387755102041 11.3 11 3 abnormal long term potentiation 0.152550929527721 0.364175083685419 0.812625906526994 0.46875 11.3 11 3 abnormal auditory brainstem response waveform shape 0.152550929527721 0.364175083685419 0.812625906526994 0.46875 11.3 11 3 decreased IgG level 0.0167761330428921 0.0873209883788731 0.812137842919471 0.468468468468468 11.3 11 3 decreased food intake 0.0392217945950436 0.159418650416946 0.811940146268322 0.468354430379747 11.3 11 3 abnormal long bone epiphyseal plate morphology 0.0697402081329755 0.226769631020623 0.809014235831319 0.466666666666667 11.3 11 3 abnormal hair cycle 0.168714169051807 0.398742513554747 0.809014235831319 0.466666666666667 11.3 11 3 abnormal spleen marginal zone morphology 0.168714169051807 0.398742513554747 0.809014235831319 0.466666666666667 11.3 11 3 interdigital webbing 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 decreased salivation 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal prostate gland morphology 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 hyperpigmentation 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal pup retrieval 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 absent egg cylinders 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal respiratory system morphology 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal bronchus morphology 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal energy homeostasis 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 bicuspid aortic valve 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal microglial cell activation 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 decreased brown adipose tissue mass 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 impaired macrophage phagocytosis 0.117071790883366 0.339666734471754 0.806326480895002 0.465116279069767 11.3 11 3 abnormal CNS synaptic transmission 0.027445650607034 0.125383022745633 0.805512009702179 0.464646464646465 11.3 11 3 abnormal seminal vesicle morphology 0.0833067275529111 0.265673698445982 0.804886612179118 0.464285714285714 11.3 11 3 myoclonus 0.186869778069751 0.434631671761108 0.804886612179118 0.464285714285714 11.3 11 3 abnormal renal tubule epithelium morphology 0.186869778069751 0.434631671761108 0.804886612179118 0.464285714285714 11.3 11 3 impaired macrophage chemotaxis 0.141435786107056 0.339666734471754 0.800123969503502 0.461538461538462 11.3 11 3 abnormal Schwann cell morphology 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 small seminal vesicle 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 abnormal ocular fundus morphology 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 pulmonary edema 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 abnormal membranous labyrinth morphology 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 absent teeth 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 uterus hypoplasia 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 absent lateral semicircular canal 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 abnormal vestibulocochlear ganglion morphology 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 abnormal retinal inner plexiform layer morphology 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 small otic vesicle 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 small interparietal bone 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 decreased endocochlear potential 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 small pituitary gland 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 increased white adipose tissue amount 0.155650150584353 0.370684298304049 0.796519807478712 0.459459459459459 11.3 11 3 decreased body height 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 increased stereotypic behavior 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal startle reflex 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal impulse conducting system conduction 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal retinal ganglion layer morphology 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal cellular extravasation 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 increased B cell proliferation 0.0929568286615921 0.288496707792527 0.79334325789754 0.457627118644068 11.3 11 3 abnormal eye electrophysiology 0.0276350275109862 0.126132350336841 0.788000879056479 0.454545454545455 11.3 11 3 abnormal aorta morphology 0.189046781961569 0.439079243818303 0.788000879056479 0.454545454545455 11.3 11 3 abnormal abdominal fat pad morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 abnormal basisphenoid bone morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 abnormal facial nerve morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 abnormal cochlear sensory epithelium morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 decreased circulating estradiol level 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 impaired humoral immune response 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 absent semicircular canals 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 increased mast cell number 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal sebaceous gland morphology 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal glossopharyngeal ganglion morphology 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 social withdrawal 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal food preference 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 variable body spotting 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal nerve fiber response 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 pulmonary hypertension 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal ureter development 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal hair medulla 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal Bruch membrane morphology 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal platelet aggregation 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal superovulation 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 decreased palatine bone horizontal plate size 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 decreased core body temperature 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 increased pancreatic beta cell proliferation 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal phrenic nerve innervation pattern to diaphragm 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 autoimmune response 0.208679201128398 0.475574450578919 0.782917002417405 0.451612903225806 11.3 11 3 abnormal intestine physiology 0.208679201128398 0.475574450578919 0.782917002417405 0.451612903225806 11.3 11 3 perinatal lethality 0.172710504036939 0.407800074790589 0.780120870265915 0.45 11.3 11 3 abnormal hair texture 0.286782471472844 0.577209993061859 0.780120870265915 0.45 11.3 11 3 decreased paired-pulse facilitation 0.286782471472844 0.577209993061859 0.780120870265915 0.45 11.3 11 3 enhanced behavioral response to xenobiotic 0.286782471472844 0.577209993061859 0.780120870265915 0.45 11.3 11 3 abnormal epidermis stratum corneum morphology 0.144586444049782 0.345493544259205 0.778351888700686 0.448979591836735 11.3 11 3 increased neutrophil cell number 0.0249325871304021 0.118763156350876 0.777131901414321 0.448275862068966 11.3 11 3 decreased retinal photoreceptor cell number 0.230631760814511 0.508145708614788 0.777131901414321 0.448275862068966 11.3 11 3 increased double-positive T cell number 0.230631760814511 0.508145708614788 0.777131901414321 0.448275862068966 11.3 11 3 increased grooming behavior 0.189673033302413 0.440328203770185 0.775558759913482 0.447368421052632 11.3 11 3 circling 0.0755937637863559 0.243890385756888 0.77502204104849 0.447058823529412 11.3 11 3 altered response to myocardial infarction 0.172952194361863 0.407983483617955 0.77048974841078 0.444444444444444 11.3 11 3 increased circulating corticosterone level 0.172952194361863 0.407983483617955 0.77048974841078 0.444444444444444 11.3 11 3 abnormal thymus medulla morphology 0.321272803973879 0.577209993061859 0.77048974841078 0.444444444444444 11.3 11 3 increased circulating glycerol level 0.321272803973879 0.577209993061859 0.77048974841078 0.444444444444444 11.3 11 3 decreased fluid intake 0.321272803973879 0.577209993061859 0.77048974841078 0.444444444444444 11.3 11 3 abnormal suckling behavior 0.0822417979216072 0.262445763091723 0.768300857080067 0.443181818181818 11.3 11 3 abnormal response to infection 0.0961851630064299 0.296297947960984 0.768051489713277 0.443037974683544 11.3 11 3 impaired fertilization 0.112925024642199 0.338343220318087 0.767737999309313 0.442857142857143 11.3 11 3 abnormal action potential 0.112925024642199 0.338343220318087 0.767737999309313 0.442857142857143 11.3 11 3 increased double-negative T cell number 0.133215875142453 0.339666734471754 0.767332003540244 0.442622950819672 11.3 11 3 absent corpus luteum 0.158128272552106 0.374435105162649 0.76678547077419 0.442307692307692 11.3 11 3 increased width of hypertrophic chondrocyte zone 0.229251509267365 0.506900559380063 0.764824382613642 0.441176470588235 11.3 11 3 abnormal skin physiology 0.229251509267365 0.506900559380063 0.764824382613642 0.441176470588235 11.3 11 3 decreased inflammatory response 0.0962797211116916 0.296405700823432 0.763610375657112 0.44047619047619 11.3 11 3 abnormal inner ear vestibule morphology 0.282894481304209 0.577209993061859 0.762784850926672 0.44 11.3 11 3 decreased acute inflammation 0.282894481304209 0.577209993061859 0.762784850926672 0.44 11.3 11 3 impaired swimming 0.13303593235338 0.339666734471754 0.76173418308793 0.439393939393939 11.3 11 3 decreased T cell proliferation 0.0393637955764401 0.159865210606359 0.761379227737004 0.439189189189189 11.3 11 3 abnormal lymph node morphology 0.18815887986587 0.437221124396405 0.758450846091861 0.4375 11.3 11 3 abnormal hair shaft morphology 0.18815887986587 0.437221124396405 0.758450846091861 0.4375 11.3 11 3 abnormal crypts of Lieberkuhn morphology 0.25233452348448 0.547616442895411 0.758450846091861 0.4375 11.3 11 3 abnormal bone marrow cell number 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 mixed cellular infiltration to dermis 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal extraembryonic endoderm formation 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 decreased cochlear coiling 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal level of surface class II molecules 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal pancreatic alpha cell morphology 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal T-helper 2 physiology 0.171475708726544 0.405076757319352 0.75648084389422 0.436363636363636 11.3 11 3 increased autoantibody level 0.226947269771553 0.503147356111174 0.755672637864419 0.435897435897436 11.3 11 3 increased eosinophil cell number 0.156723461343401 0.372911871432204 0.754955680902498 0.435483870967742 11.3 11 3 fragile skeleton 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 bidirectional circling 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 abnormal circulating insulin level 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 decreased epididymis weight 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 abnormal lens development 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 abnormal chondrocyte physiology 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 gastrointestinal hemorrhage 0.277980507456579 0.577209993061859 0.75122750470051 0.433333333333333 11.3 11 3 abnormal synaptic transmission 0.277980507456579 0.577209993061859 0.75122750470051 0.433333333333333 11.3 11 3 increased insulin secretion 0.248673664112423 0.542606796972566 0.749665701156434 0.432432432432432 11.3 11 3 abnormal pancreatic beta cell physiology 0.248673664112423 0.542606796972566 0.749665701156434 0.432432432432432 11.3 11 3 abnormal cued conditioning behavior 0.202971526887646 0.464481760011978 0.747828285222228 0.431372549019608 11.3 11 3 cochlear inner hair cell degeneration 0.202971526887646 0.464481760011978 0.747828285222228 0.431372549019608 11.3 11 3 abnormal cytotoxic T cell physiology 0.244590960176118 0.53794872983032 0.742972257396109 0.428571428571429 11.3 11 3 abnormal stria vascularis morphology 0.306514572965411 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 abnormal anxiety-related response 0.349345140415607 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 hypoalgesia 0.349345140415607 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 enhanced coordination 0.306514572965411 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 abnormal hormone level 0.306514572965411 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 abnormal zigzag hair morphology 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal adrenal gland secretion 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal endplate potential 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 decreased coping response 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 decreased vascular permeability 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 skeletal muscle necrosis 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 increased lung compliance 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 decreased compact bone area 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal immune system physiology 0.0921071626831176 0.287002176580327 0.740975020145044 0.42741935483871 11.3 11 3 polyphagia 0.217383513230914 0.494731463094143 0.738386008893664 0.425925925925926 11.3 11 3 decreased tumor growth/size 0.217383513230914 0.494731463094143 0.738386008893664 0.425925925925926 11.3 11 3 abnormal T cell differentiation 0.125831522044827 0.339666734471754 0.738068150086564 0.425742574257426 11.3 11 3 increased circulating glucose level 0.0835751401327165 0.266018120384047 0.737702950606066 0.425531914893617 11.3 11 3 increased systemic arterial blood pressure 0.240279636776386 0.528700218028535 0.737702950606066 0.425531914893617 11.3 11 3 abnormal T-helper 1 physiology 0.240279636776386 0.528700218028535 0.737702950606066 0.425531914893617 11.3 11 3 decreased IgA level 0.235856580067043 0.51942739523397 0.733446972044877 0.423076923076923 11.3 11 3 abnormal nasal bone morphology 0.338308927706829 0.577209993061859 0.733446972044877 0.423076923076923 11.3 11 3 no spontaneous movement 0.338308927706829 0.577209993061859 0.733446972044877 0.423076923076923 11.3 11 3 abnormal tectorial membrane morphology 0.338308927706829 0.577209993061859 0.733446972044877 0.423076923076923 11.3 11 3 abnormal ovarian follicle morphology 0.261427880386169 0.549938141615725 0.731965260990241 0.422222222222222 11.3 11 3 abnormal cytokine secretion 0.0863864144436263 0.271773246826035 0.731715101981017 0.422077922077922 11.3 11 3 decreased eosinophil cell number 0.2101388943483 0.478681776274172 0.731363315874295 0.421875 11.3 11 3 hyporesponsive to tactile stimuli 0.29158321379243 0.577209993061859 0.72993765638916 0.421052631578947 11.3 11 3 decreased grooming behavior 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 unresponsive to tactile stimuli 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 abnormal ear morphology 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 osteoarthritis 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 impaired righting response 0.155633097696638 0.370684298304049 0.72993765638916 0.421052631578947 11.3 11 3 abnormal T cell activation 0.202762715362745 0.464431173540358 0.726238647995296 0.418918918918919 11.3 11 3 abnormal intestinal mucosa morphology 0.284422927597406 0.577209993061859 0.725693832805502 0.418604651162791 11.3 11 3 abnormal systemic arterial blood pressure 0.31842644154042 0.577209993061859 0.722334139135106 0.416666666666667 11.3 11 3 reduced long term depression 0.31842644154042 0.577209993061859 0.722334139135106 0.416666666666667 11.3 11 3 abnormal cardiac muscle contractility 0.373789367688196 0.585885981174787 0.722334139135106 0.416666666666667 11.3 11 3 decreased ovulation rate 0.373789367688196 0.585885981174787 0.722334139135106 0.416666666666667 11.3 11 3 abnormal supraoccipital bone morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal rectum morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal superior cervical ganglion morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal pilomotor reflex 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 ear inflammation 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal gastrocnemius morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 stria vascularis degeneration 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 increased placenta weight 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal amacrine cell morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal palatine bone morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 hydrometra 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 impaired behavioral response to cocaine 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 decreased compensatory feeding amount 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal middle ear morphology 0.360078910954282 0.577209993061859 0.71735252438245 0.413793103448276 11.3 11 3 abnormal social investigation 0.224842785213715 0.502816873188414 0.715110797743755 0.4125 11.3 11 3 thin skin 0.347768857028316 0.577209993061859 0.713836090439399 0.411764705882353 11.3 11 3 decreased regulatory T cell number 0.347768857028316 0.577209993061859 0.713836090439399 0.411764705882353 11.3 11 3 abnormal urinary bladder morphology 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 enlarged sebaceous gland 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 abnormal melanosome morphology 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 pancytopenia 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 enhanced long term potentiation 0.285260469974811 0.577209993061859 0.712015080004605 0.410714285714286 11.3 11 3 abnormal response to injury 0.336547348763474 0.577209993061859 0.711221306225335 0.41025641025641 11.3 11 3 abnormal oogenesis 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 abnormal female reproductive system physiology 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 abnormal limb posture 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 abnormal occipital bone morphology 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 rough coat 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 decreased susceptibility to pharmacologically induced seizures 0.395420030801881 0.606229477115365 0.706282269376548 0.407407407407407 11.3 11 3 abnormal diaphragm morphology 0.379824085474107 0.591296452322191 0.704275785656728 0.40625 11.3 11 3 abnormal serotonin level 0.379824085474107 0.591296452322191 0.704275785656728 0.40625 11.3 11 3 abnormal nervous system electrophysiology 0.262931383695479 0.55286713181953 0.701696020874103 0.404761904761905 11.3 11 3 abnormal muscle morphology 0.353490074205659 0.577209993061859 0.701696020874103 0.404761904761905 11.3 11 3 increased percent body fat/body weight 0.33151409386133 0.577209993061859 0.700108473315564 0.403846153846154 11.3 11 3 impaired behavioral response to xenobiotic 0.397880234480344 0.60981335999375 0.693440773569702 0.4 11.3 11 3 abnormal enteric neuron morphology 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 altered righting response 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 joint inflammation 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 decreased aggression towards males 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 abnormal rostral migratory stream morphology 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 abnormal dendritic cell morphology 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 lactation failure 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 decreased monocyte cell number 0.325403619064718 0.577209993061859 0.693440773569702 0.4 11.3 11 3 head bobbing 0.38288870526567 0.591296452322191 0.693440773569702 0.4 11.3 11 3 increased pre-B cell number 0.434385958610853 0.657059940434477 0.693440773569702 0.4 11.3 11 3 decreased placenta weight 0.434385958610853 0.657059940434477 0.693440773569702 0.4 11.3 11 3 brain inflammation 0.457813331643418 0.674688016649903 0.693440773569702 0.4 11.3 11 3 abnormal induced retinal neovascularization 0.457813331643418 0.674688016649903 0.693440773569702 0.4 11.3 11 3 nuclear cataracts 0.457813331643418 0.674688016649903 0.693440773569702 0.4 11.3 11 3 abnormal excitatory postsynaptic currents 0.318952501067253 0.577209993061859 0.688995640405794 0.397435897435897 11.3 11 3 abnormal inhibitory postsynaptic currents 0.337843004003658 0.577209993061859 0.688341944352277 0.397058823529412 11.3 11 3 decreased susceptibility to injury 0.337843004003658 0.577209993061859 0.688341944352277 0.397058823529412 11.3 11 3 increased susceptibility to pharmacologically induced seizures 0.304298621549915 0.577209993061859 0.686217432178351 0.395833333333333 11.3 11 3 decreased threshold for auditory brainstem response 0.414508157530132 0.632182122535992 0.684316552864837 0.394736842105263 11.3 11 3 diarrhea 0.432380803511655 0.654424854721777 0.682934095182282 0.393939393939394 11.3 11 3 head tossing 0.432380803511655 0.654424854721777 0.682934095182282 0.393939393939394 11.3 11 3 abnormal NK cell physiology 0.372340272899987 0.585885981174787 0.682072892035772 0.39344262295082 11.3 11 3 decreased circulating progesterone level 0.452947091754891 0.674688016649903 0.6810579026131 0.392857142857143 11.3 11 3 abnormal lymphocyte physiology 0.413407015607887 0.63074836410851 0.678365974144274 0.391304347826087 11.3 11 3 abnormal innervation pattern to muscle 0.477320556316033 0.692121762655863 0.678365974144274 0.391304347826087 11.3 11 3 abnormal crista ampullaris morphology 0.477320556316033 0.692121762655863 0.678365974144274 0.391304347826087 11.3 11 3 abnormal excitatory postsynaptic potential 0.361771707335529 0.577209993061859 0.676527583970441 0.390243902439024 11.3 11 3 blepharoptosis 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 increased susceptibility to autoimmune disorder 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 abnormal macrophage chemotaxis 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 impaired leukocyte tethering or rolling 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 decreased macrophage cell number 0.444262668768112 0.670775956637741 0.669800747198007 0.386363636363636 11.3 11 3 impaired natural killer cell mediated cytotoxicity 0.424595107328467 0.647367655212725 0.66910951835673 0.385964912280702 11.3 11 3 abnormal leukocyte migration 0.440359982041556 0.665085279495064 0.666769974586252 0.384615384615385 11.3 11 3 abnormal leukocyte adhesion 0.463233663009294 0.674688016649903 0.666769974586252 0.384615384615385 11.3 11 3 abnormal mast cell morphology 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal digestion 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal otolith morphology 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 increased synaptic depression 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal dopaminergic neuron morphology 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal afterhyperpolarization 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 vestibular hair cell degeneration 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 increased cochlear inner hair cell number 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 total cataracts 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 increased susceptibility to viral infection induced morbidity/mortality 0.48475962752515 0.702703714142663 0.662847798265156 0.382352941176471 11.3 11 3 increased acute inflammation 0.524562987783608 0.749268120649856 0.660419784352097 0.380952380952381 11.3 11 3 abnormal parietal bone morphology 0.509699868910819 0.728456434309487 0.657573147350579 0.379310344827586 11.3 11 3 increased susceptibility to induced arthritis 0.509699868910819 0.728456434309487 0.657573147350579 0.379310344827586 11.3 11 3 abnormal CD8-positive, alpha-beta T cell physiology 0.509699868910819 0.728456434309487 0.657573147350579 0.379310344827586 11.3 11 3 abnormal wound healing 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 abnormal intestinal lipid absorption 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 loose skin 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 impaired behavioral response to addictive substance 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 abnormal axon guidance 0.523340699631472 0.747736927244852 0.645061184716002 0.372093023255814 11.3 11 3 abnormal immune system morphology 0.534457629525946 0.758826114980474 0.640678975580703 0.369565217391304 11.3 11 3 decreased susceptibility to induced arthritis 0.533612903857932 0.757843047871314 0.638695449340515 0.368421052631579 11.3 11 3 maternal imprinting 0.576413849433877 0.776946651389156 0.638695449340515 0.368421052631579 11.3 11 3 arrested T cell differentiation 0.564635425676016 0.776946651389156 0.635654042438893 0.366666666666667 11.3 11 3 abnormal CD4-positive, alpha-beta T cell physiology 0.542057027883049 0.769396209334713 0.634840144817333 0.366197183098592 11.3 11 3 arrested B cell differentiation 0.558475302447182 0.776946651389156 0.634244609972288 0.365853658536585 11.3 11 3 decreased susceptibility to viral infection induced morbidity/mortality 0.588061101077575 0.776946651389156 0.630400703245183 0.363636363636364 11.3 11 3 abnormal food intake 0.569230673253555 0.776946651389156 0.628116642726179 0.36231884057971 11.3 11 3 abnormal reflex 0.585641983336843 0.776946651389156 0.626022920583759 0.361111111111111 11.3 11 3 absent atrioventricular cushions 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal prepulse inhibition 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal imprinting 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 enlarged stomach 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal positive T cell selection 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal respiratory motile cilium physiology 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 decreased response to antigen 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal body temperature homeostasis 0.616894223368879 0.789573899905043 0.615149073327961 0.354838709677419 11.3 11 3 abnormal T cell proliferation 0.616894223368879 0.789573899905043 0.615149073327961 0.354838709677419 11.3 11 3 abnormal vision 0.625091844575369 0.798100880553747 0.611859506090913 0.352941176470588 11.3 11 3 abnormal touch/ nociception 0.633070947894094 0.807571273275159 0.611859506090913 0.352941176470588 11.3 11 3 abnormal dopamine level 0.640275666705662 0.816134112698096 0.606760676873489 0.35 11.3 11 3 decreased skin tensile strength 0.640275666705662 0.816134112698096 0.606760676873489 0.35 11.3 11 3 abnormal male reproductive system physiology 0.640275666705662 0.816134112698096 0.606760676873489 0.35 11.3 11 3 abnormal cochlear ganglion morphology 0.647122724950397 0.824439323080211 0.602991977017132 0.347826086956522 11.3 11 3 increased susceptibility to age related obesity 0.647122724950397 0.824439323080211 0.602991977017132 0.347826086956522 11.3 11 3 delayed wound healing 0.653367670622448 0.832182324973547 0.602991977017132 0.347826086956522 11.3 11 3 abnormal circulating glucose level 0.659864441213751 0.840027020224773 0.597793770318709 0.344827586206897 11.3 11 3 enlarged epididymis 0.659864441213751 0.840027020224773 0.597793770318709 0.344827586206897 11.3 11 3 increased dopamine level 0.665816768866996 0.8471709527144 0.595925664786463 0.34375 11.3 11 3 decreased susceptibility to parasitic infection 0.665816768866996 0.8471709527144 0.595925664786463 0.34375 11.3 11 3 increased alcohol consumption 0.694508044933485 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 abnormal neurotransmitter secretion 0.694508044933485 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 abnormal estrous cycle 0.707478948982619 0.882383183149574 0.577867311308085 0.333333333333333 11.3 11 3 abnormal pain threshold 0.707478948982619 0.882383183149574 0.577867311308085 0.333333333333333 11.3 11 3 increased vasoconstriction 0.698132006166689 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 abnormal sperm axoneme morphology 0.695849234835014 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 decreased vocalization 0.698132006166689 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 apnea 0.700964452679227 0.882190273736189 0.577867311308085 0.333333333333333 11.3 11 3 absent vibrissae 0.710943739904025 0.8835735963084 0.577867311308085 0.333333333333333 11.3 11 3 lung hemorrhage 0.75200334201773 0.90323916623327 0.560871213916671 0.323529411764706 11.3 11 3 increased activated T cell number 0.749498428541609 0.901100696470398 0.551600615339536 0.318181818181818 11.3 11 3 decreased airway responsiveness 0.749498428541609 0.901100696470398 0.551600615339536 0.318181818181818 11.3 11 3 abnormal nail morphology 0.750973258866309 0.90221974471381 0.54745324229187 0.315789473684211 11.3 11 3 altered susceptibility to infection 0.750973258866309 0.90221974471381 0.54745324229187 0.315789473684211 11.3 11 3 abnormal response to novelty 0.750973258866309 0.90221974471381 0.54745324229187 0.315789473684211 11.3 11 3 abnormal Langerhans cell physiology 0.754196113285987 0.905217289167137 0.54175060435133 0.3125 11.3 11 3 abnormal fertilization 0.754196113285987 0.905217289167137 0.54175060435133 0.3125 11.3 11 3 abnormal urinary bladder physiology 0.754196113285987 0.905217289167137 0.54175060435133 0.3125 11.3 11 3 increased susceptibility to parasitic infection 0.883621339045406 1 0.539342823887546 0.311111111111111 11.3 11 3 abnormal retinal cone cell morphology 0.794287798862764 0.9453544974503 0.527617979889991 0.304347826086957 11.3 11 3 increased susceptibility to fungal infection 0.794287798862764 0.9453544974503 0.527617979889991 0.304347826086957 11.3 11 3 abnormal circulating cytokine level 0.798415084078015 0.950039474596537 0.520080580177276 0.3 11.3 11 3 abnormal glutamate-mediated receptor currents 0.804664932199275 0.957018416851875 0.509882921742428 0.294117647058824 11.3 11 3 decreased growth hormone level 0.804664932199275 0.957018416851875 0.509882921742428 0.294117647058824 11.3 11 3 impaired conditioned place preference behavior 0.865205553151312 1 0.485408541498791 0.28 11.3 11 3 abnormal stomach mucosa morphology 0.865205553151312 1 0.485408541498791 0.28 11.3 11 3 abnormal retinal rod cell morphology 0.846517123493222 0.987437910757041 0.481556092756737 0.277777777777778 11.3 11 3 thick dermal layer 0.846517123493222 0.987437910757041 0.481556092756737 0.277777777777778 11.3 11 3 decreased bone strength 0.88667115647318 1 0.478235016254967 0.275862068965517 11.3 11 3 decreased fertilization frequency 0.880639932288548 1 0.456211035243225 0.263157894736842 11.3 11 3 abnormal regulatory T cell physiology 0.899312190011618 1 0.452243982762849 0.260869565217391 11.3 11 3 abnormal single cell response 0.91466160349313 1 0.449452353239622 0.259259259259259 11.3 11 3 abnormal thymocyte activation 0.908048215025393 1 0.433400483481064 0.25 11.3 11 3 abnormal channel response 0.94679043692875 1 0.39400043952824 0.227272727272727 11.3 11 3 decreased cytotoxic T cell cytolysis 0.986125624978774 1 0.356918045219699 0.205882352941176 11.3 11 3 increased circulating luteinizing hormone level 0.991217836353247 1 0.309571773915045 0.178571428571429 11.3 11 3 increased urine microalbumin level 0.000220775430266384 0.00673839119984822 4.383907316299 1 11.1 11 1 cystinuria 0.000220775430266384 0.00673839119984822 4.383907316299 1 11.1 11 1 aminoaciduria 9.89528490052911e-10 2.59100223053328e-07 3.86815351438147 0.882352941176471 11.1 11 1 abnormal hippocampal fimbria morphology 0.00111975236211112 0.0233086527259532 3.65325609691583 0.833333333333333 11.1 11 1 increased cardiac cell glucose uptake 0.00111975236211112 0.0233086527259532 3.65325609691583 0.833333333333333 11.1 11 1 abnormal pillar cell morphology 4.43113141463277e-05 0.00196829274891054 3.5071258530392 0.8 11.1 11 1 dilated uterus 0.000192219394812129 0.00620968499474247 3.40970569045478 0.777777777777778 11.1 11 1 abnormal infrahyoid muscle connection 0.000192219394812129 0.00620968499474247 3.40970569045478 0.777777777777778 11.1 11 1 abnormal coronary sinus connection 0.000192219394812129 0.00620968499474247 3.40970569045478 0.777777777777778 11.1 11 1 anomalous pulmonary venous connection 0.000812007902277744 0.018530914283632 3.28793048722425 0.75 11.1 11 1 failure of atrioventricular cushion closure 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 abnormal lacrimal gland morphology 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 uremia 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 abnormal spinal cord central canal morphology 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 coronary fistula 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 ductus venosus stenosis 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 abnormal inferior vena cava valve morphology 0.000537338249698997 0.0131042048639829 3.0687351214093 0.7 11.1 11 1 thick aortic valve 0.000537338249698997 0.0131042048639829 3.0687351214093 0.7 11.1 11 1 abnormal geniculate ganglion morphology 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 abnormal posterior semicircular canal morphology 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 biliary cyst 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 positive geotaxis 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 dilated bile duct 0.000340742149889052 0.0096868125468459 2.92260487753267 0.666666666666667 11.1 11 1 increased urine calcium level 6.43224266852074e-06 0.000400005090948634 2.84953975559435 0.65 11.1 11 1 absent ductus venosus valve 6.43224266852074e-06 0.000400005090948634 2.84953975559435 0.65 11.1 11 1 irregularly shaped pupil 0.000211182113948444 0.00660774224461325 2.8182261319065 0.642857142857143 11.1 11 1 abnormal glucose tolerance 0.000211182113948444 0.00660774224461325 2.8182261319065 0.642857142857143 11.1 11 1 abnormal renal reabsorbtion 0.000211182113948444 0.00660774224461325 2.8182261319065 0.642857142857143 11.1 11 1 decreased atrioventricular cushion size 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 focal hepatic necrosis 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 abnormal palatal shelf elevation 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 common atrioventricular valve 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 failure of vascular branching 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal pupil morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 tau protein deposits 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal kidney epithelium morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 Sertoli cell hypoplasia 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 stomach epithelial hyperplasia 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal bronchiole epithelium morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal foramen magnum morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 lethality during fetal growth through weaning, incomplete penetrance 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 increased circulating ferritin level 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 absent hypoglossal canal 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 decreased white adipose tissue mass 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 increased brain apoptosis 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 absent hypoglossal nerve 0.000741308364078366 0.0173145967666191 2.69778911772246 0.615384615384615 11.1 11 1 enlarged pericardium 1.0796612014102e-07 1.45170661540967e-05 2.6569135250297 0.606060606060606 11.1 11 1 decreased circulating parathyroid hormone level 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 absent seminal vesicle 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 abnormal placental transport 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 thick aortic valve cusps 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 abnormal secondary palate development 0.000440736733475359 0.0115724590097519 2.6303443897794 0.6 11.1 11 1 heterochrony 0.000440736733475359 0.0115724590097519 2.6303443897794 0.6 11.1 11 1 abnormal mineral level 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 amyloidosis 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 abnormal rostral-caudal body axis extension 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 pale placenta 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 abnormal pulmonary valve cusp morphology 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 prenatal growth retardation 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 abnormal vitelline vein connection 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 multiple persisting craniopharyngeal ducts 0.00144814336425159 0.0276034989929183 2.505089895028 0.571428571428571 11.1 11 1 abnormal vitelline vein topology 0.00144814336425159 0.0276034989929183 2.505089895028 0.571428571428571 11.1 11 1 abnormal amino acid level 1.74632184121802e-08 2.71498473751864e-06 2.49085642971534 0.568181818181818 11.1 11 1 abnormal Wolffian duct morphology 5.41579800428869e-05 0.00232272371304623 2.47786065703857 0.565217391304348 11.1 11 1 increased thymus weight 0.000841364248766803 0.0187703459085867 2.46594786541819 0.5625 11.1 11 1 abnormal circulating amino acid level 2.71121431433473e-10 8.51452230669106e-08 2.46114094950119 0.56140350877193 11.1 11 1 abnormal eye muscle morphology 1.89688831670466e-05 0.00101473326619416 2.43550406461056 0.555555555555556 11.1 11 1 abnormal mitral valve morphology 0.000490035321578025 0.0123127561861145 2.43550406461056 0.555555555555556 11.1 11 1 abnormal bile duct morphology 0.000490035321578025 0.0123127561861145 2.43550406461056 0.555555555555556 11.1 11 1 abnormal hypoglossal nerve topology 0.000490035321578025 0.0123127561861145 2.43550406461056 0.555555555555556 11.1 11 1 heart hyperplasia 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 distorted hair follicle pattern 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal lens vesicle development 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal postural reflex 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 enlarged otoliths 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 pancreas cysts 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal stria vascularis vasculature morphology 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 iris coloboma 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal ductus venosus valve topology 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 pale kidney 6.65412857220081e-06 0.000408694933909865 2.40407820571235 0.548387096774194 11.1 11 1 renal interstitial fibrosis 9.77758885532685e-08 1.36787104044088e-05 2.39122217252673 0.545454545454545 11.1 11 1 premature suture closure 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 delayed hepatic development 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 impaired luteinization 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 abnormal radial glial cell morphology 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 thin hypoglossal nerve 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 increased foot pad pigmentation 0.00454961495620966 0.0606818616813486 2.36056547800715 0.538461538461538 11.1 11 1 abnormal coping response 0.00454961495620966 0.0606818616813486 2.36056547800715 0.538461538461538 11.1 11 1 increased circulating ammonia level 0.00454961495620966 0.0606818616813486 2.36056547800715 0.538461538461538 11.1 11 1 herniated liver 0.00259946522799586 0.0411841988786376 2.33808390202613 0.533333333333333 11.1 11 1 polydipsia 1.17359488517197e-05 0.000678910994619831 2.32895076178384 0.53125 11.1 11 1 abnormal interatrial septum morphology 0.00149393765104877 0.0282598472013978 2.32089210862888 0.529411764705882 11.1 11 1 nephrocalcinosis 0.00149393765104877 0.0282598472013978 2.32089210862888 0.529411764705882 11.1 11 1 increased circulating calcium level 1.28521777999416e-08 2.14381927266333e-06 2.31151476677584 0.527272727272727 11.1 11 1 decreased liver regeneration 0.000862627397141634 0.0189892535432727 2.30731964015737 0.526315789473684 11.1 11 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000862627397141634 0.0189892535432727 2.30731964015737 0.526315789473684 11.1 11 1 liver degeneration 0.000500025738529934 0.0123762589511762 2.29633240377567 0.523809523809524 11.1 11 1 absent segment of posterior cerebral artery 0.000500025738529934 0.0123762589511762 2.29633240377567 0.523809523809524 11.1 11 1 abnormal atrioventricular cushion morphology 9.91087926463784e-05 0.00370726498808821 2.27313712696985 0.518518518518518 11.1 11 1 small thoracic cage 0.00249783998051951 0.0401047320649845 2.1919536581495 0.5 11.1 11 1 increased adipocyte glucose uptake 0.00249783998051951 0.0401047320649845 2.1919536581495 0.5 11.1 11 1 persistence of hyaloid vascular system 1.14637014294953e-05 0.000678910994619831 2.1919536581495 0.5 11.1 11 1 increased fatty acid level 5.63815794887785e-05 0.00237710472844638 2.1919536581495 0.5 11.1 11 1 abnormal Mullerian duct morphology 0.000281568507860196 0.00824001956826162 2.1919536581495 0.5 11.1 11 1 curly vibrissae 0.000483506442140271 0.0123127561861145 2.1919536581495 0.5 11.1 11 1 intestinal inflammation 0.000832726351472492 0.0186613225161065 2.1919536581495 0.5 11.1 11 1 increased urine glucose level 0.00143919838642834 0.0276034989929183 2.1919536581495 0.5 11.1 11 1 vasculature congestion 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 abnormal intestinal absorption 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 increased cochlear outer hair cell number 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 dystonia 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 abnormal embryonic growth/weight/body size 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 abnormal defecation 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 reduced cerebellar foliation 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 increased fibrosarcoma incidence 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 abnormal lateral semicircular canal morphology 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 bifid ureter 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 abnormal ear physiology 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 decreased thyroxine level 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 crystalluria 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 abnormal heart and great artery attachment 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 increased fatty acid oxidation 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 increased triglyceride level 0.000164384861346392 0.00552577489998851 2.1919536581495 0.5 11.1 11 1 subcutaneous edema 0.000164384861346392 0.00552577489998851 2.1919536581495 0.5 11.1 11 1 abnormal blood flow velocity 0.00765108654816771 0.0859236017542536 2.1919536581495 0.5 11.1 11 1 absent olfactory bulb 0.00765108654816771 0.0859236017542536 2.1919536581495 0.5 11.1 11 1 abnormal viscerocranium morphology 0.00765108654816771 0.0859236017542536 2.1919536581495 0.5 11.1 11 1 increased cardiomyocyte apoptosis 9.06088321459327e-05 0.00350278892261992 2.12553082002376 0.484848484848485 11.1 11 1 blood in lymph vessels 0.000263633141302106 0.00785374178429926 2.11636904924779 0.482758620689655 11.1 11 1 abnormal type II pneumocyte morphology 0.000450995386273027 0.0117471311345985 2.11077018932915 0.481481481481481 11.1 11 1 embryonic lethality between implantation and placentation, complete penetrance 6.00886443330804e-06 0.000388235072152046 2.09665132518648 0.478260869565217 11.1 11 1 abnormal cranial nerve morphology 0.00132951032965603 0.0260068961721248 2.09665132518648 0.478260869565217 11.1 11 1 oxidative stress 2.73833883230265e-10 8.51452230669106e-08 2.09453349556508 0.477777777777778 11.1 11 1 abnormal triglyceride level 0.0039695313055596 0.0559445276066828 2.07658767614163 0.473684210526316 11.1 11 1 abnormal neural crest cell migration 0.0039695313055596 0.0559445276066828 2.07658767614163 0.473684210526316 11.1 11 1 decreased eye pigmentation 0.0039695313055596 0.0559445276066828 2.07658767614163 0.473684210526316 11.1 11 1 abnormal vagus nerve morphology 0.00690301381271483 0.0825557242533626 2.06301520767012 0.470588235294118 11.1 11 1 common atrium 0.00690301381271483 0.0825557242533626 2.06301520767012 0.470588235294118 11.1 11 1 abnormal survival 0.00690301381271483 0.0825557242533626 2.06301520767012 0.470588235294118 11.1 11 1 kidney cortex cysts 0.000240923425981981 0.00726420632885064 2.05495655451516 0.46875 11.1 11 1 abnormal optic cup morphology 0.000410154289106912 0.0110897695016679 2.04582341427287 0.466666666666667 11.1 11 1 absent incisors 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 vagina atresia 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 abnormal pup retrieval 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 audiogenic seizures 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 placental labyrinth hypoplasia 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 absent myocardial trabeculae 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal pulmonary alveolus epithelial cell morphology 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal bile duct development 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 tracheoesophageal fistula 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 increased cochlear inner hair cell number 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal exocrine pancreas morphology 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal iris morphology 7.55886273221543e-05 0.00303268887844933 2.02334183829185 0.461538461538462 11.1 11 1 increased circulating serum albumin level 0.000216225027615731 0.00669760185819565 2.0040719160224 0.457142857142857 11.1 11 1 failure to gastrulate 2.38603254977677e-05 0.00121127672807545 2.00134899222346 0.456521739130435 11.1 11 1 increased myocardial infarction size 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 aphakia 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 abnormal vascular branching morphogenesis 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 abnormal basement membrane morphology 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 pulmonary vascular congestion 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 embryonic lethality before implantation, incomplete penetrance 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 abnormal sphenoid bone morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal stomach epithelium morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 failure of somite differentiation 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal larynx morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal bronchiole morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 patent ductus arteriosus 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 pharyngeal arch hypoplasia 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal crista ampullaris neuroepithelium morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal palate development 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 decreased palatine bone horizontal plate size 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 increased number of Howell-Jolly bodies 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 aorta dilation 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 waved hair 0.00603980369393971 0.0758788469125001 1.97275829233455 0.45 11.1 11 1 absent placental labyrinth 0.00603980369393971 0.0758788469125001 1.97275829233455 0.45 11.1 11 1 abnormal respiratory system physiology 2.1248841279563e-05 0.00111276826700869 1.968284917522 0.448979591836735 11.1 11 1 abnormal spinal nerve morphology 0.00105344457655082 0.0223969520014543 1.96519983144438 0.448275862068966 11.1 11 1 abnormal urine homeostasis 3.37514084704114e-09 6.71653028561187e-07 1.96362515209226 0.447916666666667 11.1 11 1 decreased cellular sensitivity to gamma-irradiation 0.0104271528784711 0.109128818674484 1.94840325168844 0.444444444444444 11.1 11 1 abnormal eye anterior chamber morphology 0.0104271528784711 0.109128818674484 1.94840325168844 0.444444444444444 11.1 11 1 decreased pulmonary respiratory rate 0.0104271528784711 0.109128818674484 1.94840325168844 0.444444444444444 11.1 11 1 abnormal blood homeostasis 4.59547744710582e-10 1.34485295878538e-07 1.92276636679781 0.43859649122807 11.1 11 1 failure of primitive streak formation 0.000916187491287553 0.0199040732277536 1.91795945088081 0.4375 11.1 11 1 small pancreas 0.0180707910891684 0.15911891268781 1.91795945088081 0.4375 11.1 11 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0180707910891684 0.15911891268781 1.91795945088081 0.4375 11.1 11 1 decreased adipocyte glucose uptake 0.0180707910891684 0.15911891268781 1.91795945088081 0.4375 11.1 11 1 increased circulating bilirubin level 2.73298497260172e-05 0.00133300002340133 1.902450344809 0.433962264150943 11.1 11 1 increased neuron apoptosis 2.78578084790498e-07 3.22308365542494e-05 1.89428093914154 0.432098765432099 11.1 11 1 increased circulating creatinine level 1.47220872901344e-07 1.87800985303637e-05 1.88609965933794 0.430232558139535 11.1 11 1 abnormal liver development 0.000788770210571345 0.0181672768407057 1.878817421271 0.428571428571429 11.1 11 1 decreased glycogen level 0.000788770210571345 0.0181672768407057 1.878817421271 0.428571428571429 11.1 11 1 trunk curl 0.00884991268736979 0.0957137296079668 1.878817421271 0.428571428571429 11.1 11 1 decreased cochlear outer hair cell number 0.00884991268736979 0.0957137296079668 1.878817421271 0.428571428571429 11.1 11 1 vascular ring 0.00884991268736979 0.0957137296079668 1.878817421271 0.428571428571429 11.1 11 1 abnormal somite shape 0.00260764274306952 0.0411841988786376 1.878817421271 0.428571428571429 11.1 11 1 midline facial cleft 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 translucent skin 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 absent otoliths 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 intestinal obstruction 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 amyloid beta deposits 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 abnormal ventral body wall morphology 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 premature hair loss 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 spina bifida occulta 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 decreased tongue size 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 decreased mean corpuscular hemoglobin 3.92601196922099e-06 0.000283071152853253 1.86960753195104 0.426470588235294 11.1 11 1 abnormal nerve conduction 0.00440153501553708 0.0596665850198827 1.85473001843419 0.423076923076923 11.1 11 1 abnormal myocardial trabeculae morphology 0.000208218889613543 0.00660774224461325 1.85098308910402 0.422222222222222 11.1 11 1 abnormal metabolism 0.000208218889613543 0.00660774224461325 1.85098308910402 0.422222222222222 11.1 11 1 kyphoscoliosis 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 increased liver adenoma incidence 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 abnormal blastocyst morphology 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 increased liver cholesterol level 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 abnormal hindlimb morphology 0.000107537192056693 0.0039050914633726 1.84124107284558 0.42 11.1 11 1 kidney inflammation 0.000107537192056693 0.0039050914633726 1.84124107284558 0.42 11.1 11 1 decreased neuronal precursor cell number 0.00221314848503877 0.037836473240783 1.83841274554474 0.419354838709677 11.1 11 1 abnormal organ of Corti morphology 0.00034535103522807 0.00976205341056619 1.83512399286935 0.418604651162791 11.1 11 1 hydrops fetalis 4.78201585703822e-06 0.000333119218117541 1.82662804845792 0.416666666666667 11.1 11 1 absent mesoderm 2.89097472982546e-05 0.00137087717343731 1.82662804845792 0.416666666666667 11.1 11 1 abnormal kidney physiology 0.000177712173179956 0.00585744383100397 1.82662804845792 0.416666666666667 11.1 11 1 abnormal body weight 0.00743117709810559 0.085069099305264 1.82662804845792 0.416666666666667 11.1 11 1 abnormal inner cell mass apoptosis 0.00743117709810559 0.085069099305264 1.82662804845792 0.416666666666667 11.1 11 1 abnormal glossopharyngeal nerve morphology 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 impaired embryo implantation 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 increased papilloma incidence 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 decreased left ventricle systolic pressure 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 hematuria 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 abnormal fatty acid level 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 decreased renal glomerular filtration rate 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 persistent right dorsal aorta 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 polyuria 2.49958645734443e-06 0.000200571655246589 1.82188356002036 0.415584415584416 11.1 11 1 abnormal lipid homeostasis 1.0840921757095e-09 2.69667928707737e-07 1.82100765446266 0.415384615384615 11.1 11 1 abnormal extraembryonic tissue morphology 9.89816230268779e-08 1.36787104044088e-05 1.80513830671135 0.411764705882353 11.1 11 1 abnormal gastrulation 0.000151003615325771 0.0052169651822619 1.80513830671135 0.411764705882353 11.1 11 1 failure of chorioallantoic fusion 0.000151003615325771 0.0052169651822619 1.80513830671135 0.411764705882353 11.1 11 1 overexpanded pulmonary alveoli 0.00186609289582597 0.0336370005678775 1.80513830671135 0.411764705882353 11.1 11 1 absence seizures 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 abnormal duodenum morphology 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 abnormal embryonic-extraembryonic boundary morphology 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 abnormal ductus venosus valve morphology 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 increased hepatocyte apoptosis 0.00094724165390127 0.0204892488180818 1.79852607848164 0.41025641025641 11.1 11 1 abnormal neural tube closure 1.82173599437388e-06 0.000153647538085712 1.79581745486947 0.409638554216867 11.1 11 1 abnormal circulating lipid level 0.0125468587433566 0.124841244496398 1.79341662939505 0.409090909090909 11.1 11 1 cleft upper lip 0.0125468587433566 0.124841244496398 1.79341662939505 0.409090909090909 11.1 11 1 increased exploration in new environment 2.96540216800728e-06 0.000223528420997519 1.78603631404774 0.407407407407407 11.1 11 1 abnormal heart valve morphology 0.00619708864715657 0.0768840798493863 1.78603631404774 0.407407407407407 11.1 11 1 abnormal fetal cardiomyocyte proliferation 0.00619708864715657 0.0768840798493863 1.78603631404774 0.407407407407407 11.1 11 1 decreased circulating fructosamine level 0.00619708864715657 0.0768840798493863 1.78603631404774 0.407407407407407 11.1 11 1 perimembraneous ventricular septal defect 1.77754371709679e-05 0.000971789010171046 1.77897688197641 0.405797101449275 11.1 11 1 kidney cysts 9.24935853793845e-06 0.000554404322002937 1.77725972282392 0.405405405405405 11.1 11 1 abnormal visceral yolk sac morphology 4.8210218501433e-06 0.000333119218117541 1.77575992558947 0.40506329113924 11.1 11 1 abnormal vibrissa morphology 0.000796412306206106 0.0182587613980432 1.77443867564483 0.404761904761905 11.1 11 1 decreased white adipose tissue amount 2.89330860725462e-05 0.00137087717343731 1.76664921701601 0.402985074626866 11.1 11 1 increased susceptibility to weight loss 0.00130908504240712 0.0259470043265953 1.7535629265196 0.4 11.1 11 1 abnormal pericardium morphology 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 abnormal cell proliferation 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 abnormal optic stalk morphology 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 dilated vasculature 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 kidney atrophy 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 increased erythrocyte cell number 9.08260846267274e-05 0.00350278892261992 1.7535629265196 0.4 11.1 11 1 small placenta 0.000667372492113369 0.0158309964493287 1.7535629265196 0.4 11.1 11 1 thick pulmonary interalveolar septum 0.00258430801932907 0.0410764613295914 1.7535629265196 0.4 11.1 11 1 decreased triglyceride level 0.00258430801932907 0.0410764613295914 1.7535629265196 0.4 11.1 11 1 abnormal hair cycle 0.00514429137403453 0.0659609525407778 1.7535629265196 0.4 11.1 11 1 abnormal brain vasculature morphology 0.00514429137403453 0.0659609525407778 1.7535629265196 0.4 11.1 11 1 abnormal thyroid gland morphology 0.0103554058204366 0.109128818674484 1.7535629265196 0.4 11.1 11 1 increased cellular sensitivity to ionizing radiation 0.0103554058204366 0.109128818674484 1.7535629265196 0.4 11.1 11 1 altered righting response 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 delayed intramembranous bone ossification 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 abnormal placenta size 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 abnormal rostral migratory stream morphology 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 decreased thymocyte apoptosis 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 absent chorion 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 liver vascular congestion 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 ostium primum atrial septal defect 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 decreased brown adipose tissue mass 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 perinatal lethality, incomplete penetrance 7.33303993539393e-14 4.05354151984276e-11 1.74580379852615 0.398230088495575 11.1 11 1 lethargy 1.52093850919824e-06 0.000132748580408092 1.74413516885014 0.397849462365591 11.1 11 1 pale yolk sac 5.57308889504785e-06 0.000374677260173825 1.74299929443213 0.397590361445783 11.1 11 1 decreased bone marrow cell number 2.05401788912107e-05 0.0010870998934444 1.74155222154344 0.397260273972603 11.1 11 1 abnormal mesoderm development 0.000286363881561265 0.00833134684659236 1.737019880043 0.39622641509434 11.1 11 1 overriding aortic valve 0.000557757675006956 0.0135358265032176 1.73529664603502 0.395833333333333 11.1 11 1 small spleen 2.45075008566656e-06 0.000199876748790019 1.73429300425015 0.395604395604396 11.1 11 1 kidney failure 0.00109133698338406 0.0229380232379035 1.73317265993216 0.395348837209302 11.1 11 1 corneal opacity 3.31908305269315e-05 0.0015432185221634 1.728864857132 0.394366197183099 11.1 11 1 abnormal tooth development 0.00425695186737735 0.0592319450299015 1.7269937912693 0.393939393939394 11.1 11 1 dextrocardia 0.00425695186737735 0.0592319450299015 1.7269937912693 0.393939393939394 11.1 11 1 absent corpus callosum 0.00851967129097761 0.0933598340806467 1.72224930283175 0.392857142857143 11.1 11 1 premature aging 0.00851967129097761 0.0933598340806467 1.72224930283175 0.392857142857143 11.1 11 1 pale liver 2.78164853410972e-05 0.00134356324827144 1.71801773206312 0.391891891891892 11.1 11 1 abnormal allantois morphology 0.00090780214160392 0.0198084019933311 1.71544199333439 0.391304347826087 11.1 11 1 abnormal pulmonary artery morphology 0.017278140870259 0.152951513931563 1.71544199333439 0.391304347826087 11.1 11 1 bidirectional circling 0.017278140870259 0.152951513931563 1.71544199333439 0.391304347826087 11.1 11 1 abnormal hematopoietic stem cell physiology 0.017278140870259 0.152951513931563 1.71544199333439 0.391304347826087 11.1 11 1 abnormal tooth morphology 0.000103251875772136 0.00380502282938056 1.7124637954293 0.390625 11.1 11 1 abnormal cholesterol homeostasis 0.00178064758186518 0.0323311011670776 1.71079309904351 0.390243902439024 11.1 11 1 cortical renal glomerulopathies 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 right pulmonary isomerism 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal phrenic nerve morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal white adipose tissue morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 acidosis 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 absent allantois 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal body wall morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 decreased lactate dehydrogenase level 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal pregnancy 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal metanephric mesenchyme morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 polydactyly 2.32455729738386e-06 0.000192744542574745 1.699882428769 0.387755102040816 11.1 11 1 abnormal capillary morphology 0.0069955395144529 0.0828638311533409 1.69699638050284 0.387096774193548 11.1 11 1 delayed bone ossification 3.73529842598234e-05 0.0017048724467213 1.69511082896895 0.386666666666667 11.1 11 1 eyelids open at birth 0.000625084785492406 0.014950946191465 1.68611819857654 0.384615384615385 11.1 11 1 increased leukemia incidence 0.0140765750734989 0.132854773198962 1.68611819857654 0.384615384615385 11.1 11 1 decreased circulating glycerol level 0.0140765750734989 0.132854773198962 1.68611819857654 0.384615384615385 11.1 11 1 short premaxilla 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 absent trabeculae carneae 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 small trigeminal ganglion 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 uterus hypoplasia 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 pup cannibalization 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 excessive scratching 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 abnormal tail bud morphology 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 abnormal telomere length 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 axonal dystrophy 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 abnormal GABAergic neuron morphology 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 vestibular hair cell degeneration 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 increased circulating alanine transaminase level 3.11489144595283e-05 0.00146194197581277 1.68611819857654 0.384615384615385 11.1 11 1 lethality throughout fetal growth and development, complete penetrance 1.14098670397919e-10 4.36646834792035e-08 1.68434333731488 0.384210526315789 11.1 11 1 increased respiratory quotient 0.00121844436916471 0.0247753280022129 1.67894322751877 0.382978723404255 11.1 11 1 decreased hemoglobin content 3.20940579113779e-08 4.69611582673838e-06 1.67894322751877 0.382978723404255 11.1 11 1 abnormal cell cycle 5.96456390182484e-07 6.05585824726093e-05 1.67732106014918 0.382608695652174 11.1 11 1 short maxilla 0.00573700742119489 0.0724406393919913 1.67619985623197 0.382352941176471 11.1 11 1 abnormal learning/memory/conditioning 0.000517757480277923 0.0127517003187261 1.67385552076871 0.381818181818182 11.1 11 1 hydronephrosis 2.1602207247257e-05 0.00111948938599066 1.67005993001867 0.380952380952381 11.1 11 1 abnormal pancreas morphology 0.0023863308284246 0.0401047320649845 1.67005993001867 0.380952380952381 11.1 11 1 abnormal eye pigmentation 0.0287668937991001 0.215860175943474 1.67005993001867 0.380952380952381 11.1 11 1 abnormal bile salt homeostasis 0.0287668937991001 0.215860175943474 1.67005993001867 0.380952380952381 11.1 11 1 increased B cell derived lymphoma incidence 0.00100625038613833 0.0215779985820613 1.66588478019362 0.38 11.1 11 1 decreased oocyte number 0.00100625038613833 0.0215779985820613 1.66588478019362 0.38 11.1 11 1 abnormal placenta morphology 4.13538307773517e-05 0.00187032098288477 1.66477493024013 0.379746835443038 11.1 11 1 lordosis 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 increased mortality induced by gamma-irradiation 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 decreased trophoblast giant cell number 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 abnormal outer ear morphology 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 abnormal intestine morphology 7.92767895653703e-05 0.00315521622470174 1.65877574130232 0.378378378378378 11.1 11 1 increased erythroid progenitor cell number 0.00470135923671635 0.0618763550335023 1.65877574130232 0.378378378378378 11.1 11 1 abnormal respiratory electron transport chain 0.00470135923671635 0.0618763550335023 1.65877574130232 0.378378378378378 11.1 11 1 abnormal developmental patterning 3.43497852688367e-05 0.00158231649733762 1.6573308146984 0.378048780487805 11.1 11 1 albuminuria 0.00196360357026271 0.0348890277216321 1.65614276393518 0.377777777777778 11.1 11 1 abnormal coat/ hair morphology 0.000830370181814301 0.0186613225161065 1.65430464766 0.377358490566038 11.1 11 1 atrioventricular septal defect 0.000830370181814301 0.0186613225161065 1.65430464766 0.377358490566038 11.1 11 1 increased osteoclast cell number 0.000354321783161104 0.00990309478217132 1.65294866024389 0.377049180327869 11.1 11 1 microcephaly 0.00015222182344899 0.0052227832528188 1.65190710469238 0.376811594202899 11.1 11 1 abnormal auditory brainstem response waveform shape 0.00933253751361408 0.100279425767235 1.64396524361213 0.375 11.1 11 1 poor circulation 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 disorganized yolk sac vascular plexus 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 abnormal olfaction 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 decreased aggression towards mice 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 decreased circulating triiodothyronine level 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 kidney degeneration 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 increased heart left ventricle size 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 abnormal pulmonary alveolus wall morphology 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 decreased fatty acid level 0.0231863191335511 0.187259639106196 1.64396524361213 0.375 11.1 11 1 abnormal liver morphology 2.31892879147467e-09 4.80694614066103e-07 1.64090385582141 0.374301675977654 11.1 11 1 lethality throughout fetal growth and development, incomplete penetrance 2.31892879147467e-09 4.80694614066103e-07 1.64090385582141 0.374301675977654 11.1 11 1 cleft palate 3.15539834931668e-0