term name p.value Adjusted.p.value fold_change gene_coverage subcluster cluster subset_cluster REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.000338178211187015 0.0283075055599483 5.39962551066727 0.375 1.2 1 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00140166397667427 0.0638816505157335 5.14250048634978 0.357142857142857 1.2 1 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00367840678249935 0.0887181839236708 4.23500040052335 0.294117647058824 1.2 1 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00482378796946651 0.108956353659537 3.99972260049428 0.277777777777778 1.2 1 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.00123534941876615 0.0638816505157335 3.38800032041868 0.235294117647059 1.2 1 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.00123534941876615 0.0638816505157335 3.38800032041868 0.235294117647059 1.2 1 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00318345551087104 0.0816330661934111 3.25138740427277 0.225806451612903 1.2 1 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0173104549511504 0.278303407271574 2.99979195037071 0.208333333333333 1.2 1 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.00549340957815385 0.120263412764814 2.96450028036635 0.205882352941176 1.2 1 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 9.7372514699894e-06 0.00197944412025642 2.87980027235588 0.2 1.2 1 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0114733451004495 0.209315000999227 2.87980027235588 0.2 1.2 1 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0205091312650553 0.317222758588845 2.87980027235588 0.2 1.2 1 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 3.29940277309738e-05 0.00586881268264697 2.84631422267732 0.197674418604651 1.2 1 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 4.49153756838293e-05 0.00710161995534323 2.78162526307102 0.193181818181818 1.2 1 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00290442997204693 0.0765371083374589 2.7572555799152 0.191489361702128 1.2 1 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.54473430954806e-06 0.00129343138449738 2.67078251065263 0.185483870967742 1.2 1 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.54473430954806e-06 0.00129343138449738 2.67078251065263 0.185483870967742 1.2 1 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.54473430954806e-06 0.00129343138449738 2.67078251065263 0.185483870967742 1.2 1 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.028005791157614 0.352674697498095 2.66648173366285 0.185185185185185 1.2 1 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00013705335521786 0.0150020711134627 2.64809220446518 0.183908045977011 1.2 1 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0323262827483931 0.380167771495566 2.57125024317489 0.178571428571429 1.2 1 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 6.35573382773642e-05 0.00904420923686892 2.53315764697971 0.175925925925926 1.2 1 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.0238214230670568 0.319791368154923 2.4684002334479 0.171428571428571 1.2 1 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00114660084432351 0.0638816505157335 2.46298707504121 0.171052631578947 1.2 1 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0154726504531838 0.256018390638146 2.45836608615746 0.170731707317073 1.2 1 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.0101245470568636 0.189568821867327 2.45089384881351 0.170212765957447 1.2 1 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.000390856794977023 0.0292731168027528 2.42509496619442 0.168421052631579 1.2 1 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.000390856794977023 0.0292731168027528 2.42509496619442 0.168421052631579 1.2 1 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00219971951881303 0.0638816505157335 2.39983356029657 0.166666666666667 1.2 1 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0270631879674258 0.343847468550419 2.39983356029657 0.166666666666667 1.2 1 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0421533288401226 0.454425658632534 2.39983356029657 0.166666666666667 1.2 1 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0175549505020249 0.278303407271574 2.39983356029657 0.166666666666667 1.2 1 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00562297376631987 0.121234722264745 2.36049202652121 0.163934426229508 1.2 1 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00851409257581269 0.161540716471753 2.35620022283663 0.163636363636364 1.2 1 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.000283419038537923 0.0268870194559643 2.33497319380206 0.162162162162162 1.2 1 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.0305837526477326 0.371934283788867 2.33497319380206 0.162162162162162 1.2 1 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000626765410003912 0.0405403262925258 2.32711133119667 0.161616161616162 1.2 1 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0145668304739228 0.243865879581083 2.3038402178847 0.16 1.2 1 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00470049815048082 0.107884014002165 2.29549297071845 0.159420289855072 1.2 1 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.022296026389698 0.319791368154923 2.29075021664672 0.159090909090909 1.2 1 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.022296026389698 0.319791368154923 2.29075021664672 0.159090909090909 1.2 1 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00349822695528525 0.0873329290766826 2.27352653080727 0.157894736842105 1.2 1 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00194361643612098 0.0638816505157335 2.23984465627679 0.155555555555556 1.2 1 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.0249697615329988 0.325981382215204 2.23984465627679 0.155555555555556 1.2 1 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0249697615329988 0.325981382215204 2.23984465627679 0.155555555555556 1.2 1 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0599258438157877 0.561016287828065 2.18166687299688 0.151515151515152 1.2 1 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0666630338984375 0.585314257384221 2.11750020026167 0.147058823529412 1.2 1 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.0132881369733518 0.227819504976864 2.08681179156223 0.144927536231884 1.2 1 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.00321254512075265 0.0816330661934111 2.05700019453991 0.142857142857143 1.2 1 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0378390500710796 0.414192063470355 2.05700019453991 0.142857142857143 1.2 1 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0525919946101327 0.51612695400151 2.05700019453991 0.142857142857143 1.2 1 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0525919946101327 0.51612695400151 2.05700019453991 0.142857142857143 1.2 1 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0738033023703342 0.592789745380686 2.05700019453991 0.142857142857143 1.2 1 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.0176017615280686 0.278303407271574 1.99986130024714 0.138888888888889 1.2 1 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.0192461563697788 0.300959126529617 1.97246593996978 0.136986301369863 1.2 1 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0361405484778839 0.410724111445266 1.95240696430907 0.135593220338983 1.2 1 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0361405484778839 0.410724111445266 1.95240696430907 0.135593220338983 1.2 1 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0892730114142267 0.638369322826355 1.94581099483505 0.135135135135135 1.2 1 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0892730114142267 0.638369322826355 1.94581099483505 0.135135135135135 1.2 1 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 4.28651227505479e-09 6.09970696740296e-06 1.94359143856718 0.134980988593156 1.2 1 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0499205851833563 0.503808458978128 1.93832710639338 0.134615384615385 1.2 1 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 0.000125414376054712 0.0148720547604879 1.93708538499274 0.134529147982063 1.2 1 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0287070737310231 0.358334788765314 1.93419421277634 0.134328358208955 1.2 1 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.00356560628950059 0.0874803060337817 1.92742537913582 0.133858267716535 1.2 1 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0228679112343011 0.319791368154923 1.91986684823725 0.133333333333333 1.2 1 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.0108000513777357 0.199590559876856 1.91007160921563 0.13265306122449 1.2 1 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0126879789494419 0.222901161050072 1.87187017703132 0.13 1.2 1 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.0591883598883874 0.557781696166723 1.866537213564 0.12962962962963 1.2 1 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.0214739684195932 0.319791368154923 1.86340017623027 0.129411764705882 1.2 1 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.0214739684195932 0.319791368154923 1.86340017623027 0.129411764705882 1.2 1 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.0214739684195932 0.319791368154923 1.86340017623027 0.129411764705882 1.2 1 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.0465562717302202 0.486778796976293 1.85793565958444 0.129032258064516 1.2 1 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.106279535656478 0.692701924137765 1.84602581561274 0.128205128205128 1.2 1 2 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.0822482421489001 0.603295095762293 1.83817038661013 0.127659574468085 1.2 1 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.0822482421489001 0.603295095762293 1.83817038661013 0.127659574468085 1.2 1 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 0.00051664319666832 0.0350087270885247 1.83260017331738 0.127272727272727 1.2 1 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 2.10742711119277e-06 0.00129343138449738 1.8252255247326 0.126760563380282 1.2 1 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.0315452891564921 0.374200728790312 1.82265840022524 0.126582278481013 1.2 1 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.57822942973907e-05 0.0110971095259261 1.81830392623153 0.126279863481229 1.2 1 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 0.00183681766996845 0.0638816505157335 1.80971055366626 0.12568306010929 1.2 1 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.0891002789451081 0.638369322826355 1.79987517022242 0.125 1.2 1 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.0891002789451081 0.638369322826355 1.79987517022242 0.125 1.2 1 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.115335600006242 0.692701924137765 1.79987517022242 0.125 1.2 1 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.115335600006242 0.692701924137765 1.79987517022242 0.125 1.2 1 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.115335600006242 0.692701924137765 1.79987517022242 0.125 1.2 1 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.00261889136204301 0.0703147624186266 1.78970638394998 0.124293785310734 1.2 1 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0587581375793161 0.557418865169112 1.77218478298823 0.123076923076923 1.2 1 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 0.000421782688406322 0.0300098382801098 1.76539480297678 0.122605363984674 1.2 1 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.0962530085554379 0.655349431456402 1.76314302389135 0.122448979591837 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.12474516909118 0.693096045844952 1.75597577582676 0.121951219512195 1.2 1 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.0632332479256057 0.584291635052837 1.7453334983975 0.121212121212121 1.2 1 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.0679147630706337 0.585314257384221 1.71928374469008 0.119402985074627 1.2 1 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0679147630706337 0.585314257384221 1.71928374469008 0.119402985074627 1.2 1 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0679147630706337 0.585314257384221 1.71928374469008 0.119402985074627 1.2 1 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.0244793801088971 0.325552877522996 1.71731208901956 0.119266055045872 1.2 1 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.00254029582595272 0.0695161723140523 1.71416682878326 0.119047619047619 1.2 1 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.0385256752037105 0.418488823014351 1.7031076879524 0.118279569892473 1.2 1 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.0261687267705282 0.335478362112267 1.70170016093756 0.118181818181818 1.2 1 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.111441716339223 0.692701924137765 1.69400016020934 0.117647058823529 1.2 1 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.144573273894995 0.710073666019745 1.67430248392784 0.116279069767442 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0298016935270777 0.368763564252448 1.67131265806368 0.116071428571429 1.2 1 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 0.0778999876220578 0.592789745380686 1.66944943324978 0.115942028985507 1.2 1 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.119466211707379 0.693096045844952 1.66142323405147 0.115384615384615 1.2 1 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.119466211707379 0.693096045844952 1.66142323405147 0.115384615384615 1.2 1 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 0.00165967133431272 0.0638816505157335 1.66142323405147 0.115384615384615 1.2 1 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 0.0216983242063914 0.319791368154923 1.66142323405147 0.115384615384615 1.2 1 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 0.00513737965713813 0.114226425814181 1.64560015563193 0.114285714285714 1.2 1 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.0832041084545608 0.607176647850462 1.64560015563193 0.114285714285714 1.2 1 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.0337876083343541 0.394096448031032 1.64199138336081 0.114035087719298 1.2 1 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.0699251045364143 0.585314257384221 1.64039256020272 0.113924050632911 1.2 1 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.0699251045364143 0.585314257384221 1.64039256020272 0.113924050632911 1.2 1 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.0699251045364143 0.585314257384221 1.64039256020272 0.113924050632911 1.2 1 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.0260534057376471 0.335478362112267 1.62394752200519 0.112781954887218 1.2 1 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.0449250385549842 0.473543184175871 1.61484127421825 0.11214953271028 1.2 1 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.113125755403547 0.692701924137765 1.59988904019771 0.111111111111111 1.2 1 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.0792022527704977 0.594756758915518 1.59988904019771 0.111111111111111 1.2 1 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.0792022527704977 0.594756758915518 1.59988904019771 0.111111111111111 1.2 1 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.165651716308184 0.720893566474792 1.59988904019771 0.111111111111111 1.2 1 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.176621375586415 0.720893566474792 1.56510884367167 0.108695652173913 1.2 1 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.176621375586415 0.720893566474792 1.56510884367167 0.108695652173913 1.2 1 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.176621375586415 0.720893566474792 1.56510884367167 0.108695652173913 1.2 1 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00744329324164103 0.147108420595211 1.54275014590494 0.107142857142857 1.2 1 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00744329324164103 0.147108420595211 1.54275014590494 0.107142857142857 1.2 1 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00744329324164103 0.147108420595211 1.54275014590494 0.107142857142857 1.2 1 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.112809666174481 0.692701924137765 1.5358934785898 0.106666666666667 1.2 1 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.099889776306938 0.673664225994184 1.52460014418841 0.105882352941176 1.2 1 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.0747506837500173 0.592789745380686 1.52297129788051 0.105769230769231 1.2 1 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.163594209969779 0.720893566474792 1.51568435387152 0.105263157894737 1.2 1 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.119335957879384 0.693096045844952 1.51568435387151 0.105263157894737 1.2 1 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.199339527479924 0.742532921170228 1.49989597518535 0.104166666666667 1.2 1 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.199339527479924 0.742532921170228 1.49989597518535 0.104166666666667 1.2 1 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.0308420558588097 0.371934283788867 1.48685340148809 0.103260869565217 1.2 1 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.1513761542269 0.710073666019745 1.48225014018317 0.102941176470588 1.2 1 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.132973089480961 0.699191832615336 1.47682065249019 0.102564102564103 1.2 1 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0692862987998385 0.585314257384221 1.47391352522151 0.102362204724409 1.2 1 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.211053904630434 0.758408349214917 1.4692858532428 0.102040816326531 1.2 1 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.18294724688151 0.720893566474792 1.4643052232318 0.101694915254237 1.2 1 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.140077087784572 0.709358348460663 1.45812672018019 0.10126582278481 1.2 1 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.140077087784572 0.709358348460663 1.45812672018019 0.10126582278481 1.2 1 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.109033491481083 0.692701924137765 1.45444458199792 0.101010101010101 1.2 1 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.19294792180706 0.729438522922839 1.43990013617794 0.1 1.2 1 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.147366233628548 0.710073666019745 1.43990013617794 0.1 1.2 1 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.16816826623447 0.720893566474792 1.43990013617794 0.1 1.2 1 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.222981901301094 0.772741546891361 1.43990013617794 0.1 1.2 1 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0943176075000878 0.647225687310482 1.4280001350525 0.0991735537190083 1.2 1 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.154836258928061 0.710073666019745 1.42212359128685 0.0987654320987654 1.2 1 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.154836258928061 0.710073666019745 1.42212359128685 0.0987654320987654 1.2 1 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 0.000182229978757421 0.0185223756979865 1.4196198525698 0.0985915492957746 1.2 1 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.176858416931662 0.720893566474792 1.4196198525698 0.0985915492957746 1.2 1 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.203149950441406 0.742532921170228 1.41629521591273 0.0983606557377049 1.2 1 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.235105834449124 0.772741546891361 1.41166680017445 0.0980392156862745 1.2 1 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.103333531838934 0.692701924137765 1.4047806206614 0.0975609756097561 1.2 1 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.162482584534536 0.720893566474792 1.4047806206614 0.0975609756097561 1.2 1 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.0794123571285654 0.594756758915518 1.39345174468833 0.0967741935483871 1.2 1 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.108026932837802 0.692701924137765 1.39345174468833 0.0967741935483871 1.2 1 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.194790329382065 0.729438522922839 1.38072615797885 0.0958904109589041 1.2 1 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.178284364541424 0.720893566474792 1.37133346302661 0.0952380952380952 1.2 1 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.178284364541424 0.720893566474792 1.37133346302661 0.0952380952380952 1.2 1 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 0.000316014828887011 0.0281055688441385 1.36823089863062 0.0950226244343891 1.2 1 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00604813254418871 0.126566067799714 1.36717790707804 0.094949494949495 1.2 1 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.204016554204282 0.742532921170228 1.36206769638454 0.0945945945945946 1.2 1 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.204016554204282 0.742532921170228 1.36206769638454 0.0945945945945946 1.2 1 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 0.00375123661803939 0.0889668284578342 1.36172692388106 0.0945709281961471 1.2 1 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.259870359395535 0.808067972510682 1.35839635488485 0.0943396226415094 1.2 1 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.259870359395535 0.808067972510682 1.35839635488485 0.0943396226415094 1.2 1 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.186429256825526 0.720893566474792 1.35520012816747 0.0941176470588235 1.2 1 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 0.186429256825526 0.720893566474792 1.35520012816747 0.0941176470588235 1.2 1 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.186429256825526 0.720893566474792 1.35520012816747 0.0941176470588235 1.2 1 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 0.0975546223607078 0.661048702948987 1.34990637766682 0.09375 1.2 1 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.234848389408475 0.772741546891361 1.34990637766682 0.09375 1.2 1 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.234848389408475 0.772741546891361 1.34990637766682 0.09375 1.2 1 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 5.56398094050616e-06 0.00131959081305671 1.34787294864946 0.0936087798579729 1.2 1 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.157001491063255 0.710073666019745 1.34570106184854 0.0934579439252336 1.2 1 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.157001491063255 0.710073666019745 1.34570106184854 0.0934579439252336 1.2 1 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.133324543552392 0.699191832615336 1.33944198714227 0.0930232558139535 1.2 1 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.194729360624829 0.729438522922839 1.33944198714227 0.0930232558139535 1.2 1 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 0.123153045627531 0.693096045844952 1.33705012645094 0.0928571428571429 1.2 1 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 0.123153045627531 0.693096045844952 1.33705012645094 0.0928571428571429 1.2 1 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.150537557791893 0.710073666019745 1.33100012587877 0.092436974789916 1.2 1 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.128077976007732 0.695629617782455 1.32756750144065 0.0921985815602837 1.2 1 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 0.118395683440252 0.693096045844952 1.32622380963758 0.0921052631578947 1.2 1 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.222948785296035 0.772741546891361 1.32622380963758 0.0921052631578947 1.2 1 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.170408428216232 0.720893566474792 1.32100929924582 0.0917431192660551 1.2 1 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.193488872670772 0.729438522922839 1.30900012379813 0.0909090909090909 1.2 1 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.20129981732342 0.742532921170228 1.29591012256015 0.09 1.2 1 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.20129981732342 0.742532921170228 1.29591012256015 0.09 1.2 1 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.252418226714152 0.806685658975812 1.27586088015767 0.0886075949367089 1.2 1 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 0.157908748589022 0.71108907988031 1.2599126191557 0.0875 1.2 1 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.290598639789152 0.814019418149534 1.25208707493734 0.0869565217391304 1.2 1 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.290598639789152 0.814019418149534 1.25208707493734 0.0869565217391304 1.2 1 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.290598639789152 0.814019418149534 1.25208707493734 0.0869565217391304 1.2 1 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.233779399728043 0.772741546891361 1.2460674255386 0.0865384615384615 1.2 1 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.148621079203592 0.710073666019745 1.24531903669443 0.0864864864864865 1.2 1 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 0.192583613989939 0.729438522922839 1.24307925425434 0.0863309352517986 1.2 1 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.10684749581752 0.692701924137765 1.24226678415352 0.0862745098039216 1.2 1 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.323971708588625 0.851788162816933 1.24129322084305 0.0862068965517241 1.2 1 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 0.0315559293428233 0.374200728790312 1.24036341318699 0.0861423220973783 1.2 1 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.153415024972652 0.710073666019745 1.23862377305629 0.0860215053763441 1.2 1 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.1743125176601 0.720893566474792 1.23672404334302 0.0858895705521472 1.2 1 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.179962660661316 0.720893566474792 1.22918304307873 0.0853658536585366 1.2 1 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.179962660661316 0.720893566474792 1.22918304307873 0.0853658536585366 1.2 1 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.171335028304256 0.720893566474792 1.22718761606074 0.0852272727272727 1.2 1 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.313635078421741 0.851722741591867 1.2168170164884 0.0845070422535211 1.2 1 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 0.0614778903042964 0.571784561457606 1.19991678014828 0.0833333333333333 1.2 1 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 0.214317095708371 0.768194526934537 1.19991678014828 0.0833333333333333 1.2 1 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 0.0128842644083237 0.22358912503713 1.19631342645414 0.0830830830830831 1.2 1 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.209507037352591 0.754755732032245 1.19281668085746 0.0828402366863905 1.2 1 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.116553240334762 0.693096045844952 1.19255532750934 0.0828220858895705 1.2 1 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 0.220813785334207 0.772741546891361 1.19227399810912 0.0828025477707006 1.2 1 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 0.260819551190281 0.808067972510682 1.19000011254375 0.0826446280991736 1.2 1 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 0.260819551190281 0.808067972510682 1.19000011254375 0.0826446280991736 1.2 1 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.157022029423701 0.710073666019745 1.18580011214654 0.0823529411764706 1.2 1 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.215661934712626 0.771072696221273 1.18580011214654 0.0823529411764706 1.2 1 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.363250884430489 0.8999016947118 1.18024601326061 0.0819672131147541 1.2 1 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.285634708484099 0.808067972510682 1.17810011141831 0.0818181818181818 1.2 1 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 0.234048992593662 0.772741546891361 1.1772768409002 0.0817610062893082 1.2 1 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.324926127294018 0.851788162816933 1.17201173874949 0.0813953488372093 1.2 1 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.206322865523424 0.745171161522419 1.16563344357262 0.080952380952381 1.2 1 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.335579018509746 0.858865006006058 1.15854033945351 0.0804597701149425 1.2 1 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.335579018509746 0.858865006006058 1.15854033945351 0.0804597701149425 1.2 1 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.346278434553052 0.879918236373203 1.14537510832336 0.0795454545454545 1.2 1 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.389510085880736 0.917670285113058 1.14277788585551 0.0793650793650794 1.2 1 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 0.292907736600167 0.818875656546242 1.13948931639981 0.079136690647482 1.2 1 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 0.310967002770615 0.846091864134961 1.13377963478578 0.078740157480315 1.2 1 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.00669835631527809 0.138141464299141 1.13084839963243 0.0785365853658537 1.2 1 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.142648840285959 0.710073666019745 1.1299664745791 0.07847533632287 1.2 1 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.245786636332846 0.796837664113957 1.12803236474769 0.0783410138248848 1.2 1 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.266356072134227 0.808067972510682 1.12492198138902 0.078125 1.2 1 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.325228819332751 0.851788162816933 1.10761548936765 0.0769230769230769 1.2 1 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 0.301904876031995 0.836942883215414 1.1015629457099 0.0765027322404372 1.2 1 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.32219377880424 0.851788162816933 1.10056061363919 0.0764331210191083 1.2 1 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 0.281803827527578 0.808067972510682 1.09768171816255 0.0762331838565022 1.2 1 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.389366051408393 0.917670285113058 1.09557619057017 0.0760869565217391 1.2 1 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.262152307441331 0.808067972510682 1.09162104186775 0.075812274368231 1.2 1 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.326542981686216 0.851788162816933 1.08829661455309 0.0755813953488372 1.2 1 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.400167804821678 0.930455533106613 1.08379580142426 0.0752688172043011 1.2 1 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.330273087548395 0.851788162816933 1.0780001019514 0.0748663101604278 1.2 1 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.241883569028437 0.787643749948435 1.07621401930825 0.0747422680412371 1.2 1 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.410965000156814 0.932955522626763 1.07226605885591 0.074468085106383 1.2 1 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.431102100582259 0.95109812267993 1.06659269346514 0.0740740740740741 1.2 1 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.396189958325662 0.930327245375275 1.06222141193455 0.0737704918032787 1.2 1 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 0.315062571778947 0.851788162816933 1.05875010013084 0.0735294117647059 1.2 1 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.366514265554492 0.8999016947118 1.04992718262975 0.0729166666666667 1.2 1 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.454443842393263 0.955204708605042 1.04089166470694 0.072289156626506 1.2 1 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.48010403212344 0.974275650379033 1.02850009726996 0.0714285714285714 1.2 1 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.19454378897172 0.729438522922839 1.0276365371547 0.0713685978169605 1.2 1 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.403306871406912 0.932955522626763 1.02327928459346 0.0710659898477157 1.2 1 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.425398755008268 0.939972714870753 1.02186461277144 0.0709677419354839 1.2 1 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.477553931787593 0.974275650379033 1.0164000961256 0.0705882352941176 1.2 1 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.450624745866419 0.954800011072507 1.00246212012388 0.069620253164557 1.2 1 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 0.388298715878899 0.917670285113058 1.00100009466916 0.0695187165775401 1.2 1 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.505211805785402 0.99195997051917 0.999930650123569 0.0694444444444444 1.2 1 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.505211805785402 0.99195997051917 0.999930650123569 0.0694444444444444 1.2 1 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.505211805785402 0.99195997051917 0.999930650123569 0.0694444444444444 1.2 1 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.480314153307555 0.974275650379033 0.989244368366523 0.0687022900763359 1.2 1 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.480314153307555 0.974275650379033 0.989244368366523 0.0687022900763359 1.2 1 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.445754706015033 0.954800011072507 0.988772625701589 0.0686695278969957 1.2 1 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.475719897326212 0.974275650379033 0.98378270173648 0.0683229813664596 1.2 1 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.489534146184827 0.974275650379033 0.981750092848595 0.0681818181818182 1.2 1 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.511640280960568 0.99195997051917 0.981750092848595 0.0681818181818182 1.2 1 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.484039487253103 0.974275650379033 0.977709969009712 0.0679012345679012 1.2 1 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.522817974623596 0.99195997051917 0.970719192928948 0.0674157303370786 1.2 1 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.411330731670703 0.932955522626763 0.963405154404769 0.0669077757685353 1.2 1 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.533892006380606 1 0.959933424118626 0.0666666666666667 1.2 1 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.534915004905303 1 0.945919797489157 0.0656934306569343 1.2 1 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 0.507481651161585 0.99195997051917 0.94052574991405 0.0653188180404355 1.2 1 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 0.550194300105693 1 0.93652041377427 0.0650406504065041 1.2 1 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.55760351006193 1 0.933268606781998 0.0648148148148148 1.2 1 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 0.540867375806479 1 0.928967829792219 0.0645161290322581 1.2 1 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.561427510925974 1 0.925650087542961 0.0642857142857143 1.2 1 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.554305685335307 1 0.925237035295061 0.0642570281124498 1.2 1 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.587499185030258 1 0.909410612322909 0.0631578947368421 1.2 1 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.611178735523348 1 0.888827244554283 0.0617283950617284 1.2 1 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.619487105176599 1 0.883374316673582 0.0613496932515337 1.2 1 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.622112579988318 1 0.877987887913378 0.0609756097560976 1.2 1 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.648129553022647 1 0.874225082679463 0.0607142857142857 1.2 1 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.66397558374287 1 0.84700008010467 0.0588235294117647 1.2 1 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.671979340570006 1 0.84081759776814 0.0583941605839416 1.2 1 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.682776676652988 1 0.836071046812997 0.0580645161290323 1.2 1 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.685567927354564 1 0.826172209282424 0.0573770491803279 1.2 1 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.711396383086911 1 0.815037812930909 0.0566037735849057 1.2 1 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.711396383086911 1 0.815037812930909 0.0566037735849057 1.2 1 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.71021874393482 1 0.811211344325599 0.0563380281690141 1.2 1 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.726459412085123 1 0.785400074278876 0.0545454545454545 1.2 1 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.785398513201621 1 0.71995006808897 0.05 1.2 1 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 6.74556438128553e-05 0.000406734665871581 2.32099853157122 1 1.1 1 1 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00247377041640824 0.00907261675914673 2.32099853157122 1 1.1 1 1 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.00247377041640824 0.00907261675914673 2.32099853157122 1 1.1 1 1 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00247377041640824 0.00907261675914673 2.32099853157122 1 1.1 1 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 1.5975009513129e-05 0.000118398117381159 2.12758198727362 0.916666666666667 1.1 1 1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.000148025675002942 0.000832571286676628 2.0888986784141 0.9 1.1 1 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.000148025675002942 0.000832571286676628 2.0888986784141 0.9 1.1 1 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.00386766404001543 0.0132939273645941 1.98942731277533 0.857142857142857 1.1 1 1 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00386766404001543 0.0132939273645941 1.98942731277533 0.857142857142857 1.1 1 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00386766404001543 0.0132939273645941 1.98942731277533 0.857142857142857 1.1 1 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 7.52732753848886e-05 0.000446307795302902 1.96392183440642 0.846153846153846 1.1 1 1 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 CAM-PDE 1 ACTIVATION%REACTOME%REACT_227001.1 CAM-PDE 1 ACTIVATION 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0111194590868618 0.0312874499678427 1.93416544297602 0.833333333333333 1.1 1 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.000594464145534409 0.00281974159698488 1.89899879855827 0.818181818181818 1.1 1 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00163137183838142 0.00634273804922612 1.85679882525697 0.8 1.1 1 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000254912053925613 0.0013385234418308 1.82364170337739 0.785714285714286 1.1 1 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 5.54924338739972e-11 2.82020476438207e-09 1.80522108011095 0.777777777777778 1.1 1 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.00438730346026337 0.0147243698678179 1.80522108011095 0.777777777777778 1.1 1 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.13330661039082e-06 1.52141066659069e-05 1.78538348582401 0.769230769230769 1.1 1 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000672209151827271 0.00311656061738434 1.78538348582401 0.769230769230769 1.1 1 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000672209151827271 0.00311656061738434 1.78538348582401 0.769230769230769 1.1 1 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.9175714110883e-06 3.07533638368789e-05 1.76395888399413 0.76 1.1 1 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 2.9175714110883e-06 3.07533638368789e-05 1.76395888399413 0.76 1.1 1 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 2.10612290282921e-07 3.56787248895948e-06 1.74074889867841 0.75 1.1 1 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 4.48316812782396e-05 0.000286078396676838 1.74074889867841 0.75 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.000275444411689493 0.00142529962848781 1.74074889867841 0.75 1.1 1 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.000275444411689493 0.00142529962848781 1.74074889867841 0.75 1.1 1 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000275444411689493 0.00142529962848781 1.74074889867841 0.75 1.1 1 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00173877345690747 0.00670535129858898 1.74074889867841 0.75 1.1 1 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0115081657353027 0.0321100389045798 1.74074889867841 0.75 1.1 1 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0115081657353027 0.0321100389045798 1.74074889867841 0.75 1.1 1 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0115081657353027 0.0321100389045798 1.74074889867841 0.75 1.1 1 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.000694452280829252 0.00316732562698726 1.70206558981889 0.733333333333333 1.1 1 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.000694452280829252 0.00316732562698726 1.70206558981889 0.733333333333333 1.1 1 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 4.62774821769597e-05 0.000292589413972882 1.6879989320518 0.727272727272727 1.1 1 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 4.62774821769597e-05 0.000292589413972882 1.6879989320518 0.727272727272727 1.1 1 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000279327815065738 0.00143495841457959 1.67627671724588 0.722222222222222 1.1 1 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000279327815065738 0.00143495841457959 1.67627671724588 0.722222222222222 1.1 1 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 7.8309105718576e-06 6.08928182718763e-05 1.65785609397944 0.714285714285714 1.1 1 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00171545189658141 0.00663339143705258 1.65785609397944 0.714285714285714 1.1 1 1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0292489467039779 0.0677870540061246 1.65785609397944 0.714285714285714 1.1 1 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 7.0952293210899e-09 1.65516579080507e-07 1.64404062652961 0.708333333333333 1.1 1 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 1.3352314103e-06 1.74315073106138e-05 1.63835190463851 0.705882352941177 1.1 1 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000678941525923503 0.00311656061738434 1.63835190463851 0.705882352941177 1.1 1 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.000678941525923503 0.00311656061738434 1.63835190463851 0.705882352941177 1.1 1 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.000678941525923503 0.00311656061738434 1.63835190463851 0.705882352941177 1.1 1 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.87660599100745e-05 0.000135553823614396 1.63329526295752 0.703703703703704 1.1 1 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0108178105779879 0.0308529410234188 1.62469897209985 0.7 1.1 1 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 3.15966839635048e-06 3.25812183188894e-05 1.6176656432163 0.696969696969697 1.1 1 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 4.43462283155721e-05 0.000286078396676838 1.60684513724161 0.692307692307692 1.1 1 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 4.43462283155721e-05 0.000286078396676838 1.60684513724161 0.692307692307692 1.1 1 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.00413854314333792 0.0140888681649997 1.60684513724161 0.692307692307692 1.1 1 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.07676542175085e-10 8.20899220875407e-09 1.59568649045521 0.6875 1.1 1 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00161626959293673 0.00634273804922612 1.59568649045521 0.6875 1.1 1 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00161626959293673 0.00634273804922612 1.59568649045521 0.6875 1.1 1 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00161626959293673 0.00634273804922612 1.59568649045521 0.6875 1.1 1 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 3.03114197630795e-06 3.16791979778447e-05 1.59154185022026 0.685714285714286 1.1 1 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000256053779186404 0.00133957546978769 1.58249899879856 0.681818181818182 1.1 1 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 8.79904006938796e-08 1.58494101503026e-06 1.58025431936764 0.680851063829787 1.1 1 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 1.70514272147847e-05 0.000125073097559993 1.57228932783857 0.67741935483871 1.1 1 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 2.00729705433164e-07 3.4833947662365e-06 1.56415118431973 0.673913043478261 1.1 1 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.76971954178512e-08 1.43588453350133e-06 1.54733235438081 0.666666666666667 1.1 1 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 7.76971954178512e-08 1.43588453350133e-06 1.54733235438081 0.666666666666667 1.1 1 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000588382012941418 0.00280022610172454 1.54733235438081 0.666666666666667 1.1 1 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 1.58433805657309e-05 0.000118037332696519 1.54733235438081 0.666666666666667 1.1 1 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 1.58433805657309e-05 0.000118037332696519 1.54733235438081 0.666666666666667 1.1 1 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 9.55065651265677e-05 0.000554717723163697 1.54733235438081 0.666666666666667 1.1 1 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 9.55065651265677e-05 0.000554717723163697 1.54733235438081 0.666666666666667 1.1 1 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 9.55065651265677e-05 0.000554717723163697 1.54733235438081 0.666666666666667 1.1 1 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00375745112808573 0.0130246757916652 1.54733235438081 0.666666666666667 1.1 1 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00375745112808573 0.0130246757916652 1.54733235438081 0.666666666666667 1.1 1 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.00971183014410543 0.0283127534369859 1.54733235438081 0.666666666666667 1.1 1 1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 48%5605562 ADRENOCEPTORS 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0257498902853812 0.0622106856979582 1.54733235438081 0.666666666666667 1.1 1 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 2.99041563081645e-08 5.91022422590529e-07 1.53351688693098 0.660714285714286 1.1 1 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 8.7046723341332e-05 0.000511849121135188 1.52065421033976 0.655172413793103 1.1 1 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000214402425336471 0.00115566155777954 1.51757596295041 0.653846153846154 1.1 1 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.82941467696517e-09 5.20651417064287e-08 1.51369469450297 0.652173913043478 1.1 1 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 9.27293568618496e-07 1.28110558072245e-05 1.51369469450297 0.652173913043478 1.1 1 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000531044070599033 0.00255295848804873 1.51369469450297 0.652173913043478 1.1 1 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.00132463791760038 0.00557962433456978 1.50864904552129 0.65 1.1 1 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 3.21031777630685e-05 0.000218578095487304 1.50182257925197 0.647058823529412 1.1 1 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.00333470438246099 0.0117748990973746 1.50182257925197 0.647058823529412 1.1 1 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.000192085907031031 0.00105130094501983 1.4920704845815 0.642857142857143 1.1 1 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000192085907031031 0.00105130094501983 1.4920704845815 0.642857142857143 1.1 1 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00850010738749963 0.0256807915337834 1.4920704845815 0.642857142857143 1.1 1 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.15721056345026e-07 4.99190070198858e-06 1.4889424542155 0.641509433962264 1.1 1 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 2.87608776947943e-05 0.000196763119998521 1.48286017294828 0.638888888888889 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.00116995642201269 0.00508825764701246 1.47699906554532 0.636363636363636 1.1 1 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0220551758056799 0.0543925739540424 1.47699906554532 0.636363636363636 1.1 1 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 6.99007463509933e-05 0.000417935975031359 1.47699906554532 0.636363636363636 1.1 1 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 6.99007463509933e-05 0.000417935975031359 1.47699906554532 0.636363636363636 1.1 1 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00017035601306342 0.000946939869489245 1.46996573666177 0.633333333333333 1.1 1 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.00291488717022339 0.0104480716454103 1.4658938094134 0.631578947368421 1.1 1 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00291488717022339 0.0104480716454103 1.4658938094134 0.631578947368421 1.1 1 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00291488717022339 0.0104480716454103 1.4658938094134 0.631578947368421 1.1 1 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 6.266780759294e-09 1.48627150341256e-07 1.46254701989419 0.63013698630137 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00102235547939302 0.00450406144636617 1.45062408223201 0.625 1.1 1 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00732608702000074 0.0228618899768883 1.45062408223201 0.625 1.1 1 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 RELAXIN RECEPTORS%REACTOME%REACT_198713.2 RELAXIN RECEPTORS 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0588169149851032 0.119908982842123 1.45062408223201 0.625 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 5.43446564493662e-05 0.000334772494058217 1.4427828709767 0.621621621621622 1.1 1 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 5.43446564493662e-05 0.000334772494058217 1.4427828709767 0.621621621621622 1.1 1 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 5.43446564493662e-05 0.000334772494058217 1.4427828709767 0.621621621621622 1.1 1 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 3.04992981234344e-06 3.16791979778447e-05 1.43901908957416 0.62 1.1 1 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00252105376267121 0.00917508824624332 1.43680861478218 0.619047619047619 1.1 1 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.00252105376267121 0.00917508824624332 1.43680861478218 0.619047619047619 1.1 1 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.00252105376267121 0.00917508824624332 1.43680861478218 0.619047619047619 1.1 1 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.000130958357146872 0.000745414968879994 1.43355791655869 0.617647058823529 1.1 1 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.000130958357146872 0.000745414968879994 1.43355791655869 0.617647058823529 1.1 1 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0186290893453335 0.0477643137629 1.42830678865921 0.615384615384615 1.1 1 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0186290893453335 0.0477643137629 1.42830678865921 0.615384615384615 1.1 1 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0186290893453335 0.0477643137629 1.42830678865921 0.615384615384615 1.1 1 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 1.73303022439549e-05 0.000125821531087489 1.4242490989187 0.613636363636364 1.1 1 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 1.73303022439549e-05 0.000125821531087489 1.4242490989187 0.613636363636364 1.1 1 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 8.00881232688072e-09 1.80897459383353e-07 1.42161160058737 0.6125 1.1 1 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.35446238921603e-06 5.05162010047732e-05 1.42101950912524 0.612244897959184 1.1 1 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 1.51774352627528e-12 1.04145400159174e-10 1.41945364740719 0.611570247933884 1.1 1 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 1.51774352627528e-12 1.04145400159174e-10 1.41945364740719 0.611570247933884 1.1 1 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.00625211720860976 0.020037754026693 1.41838799151574 0.611111111111111 1.1 1 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00625211720860976 0.020037754026693 1.41838799151574 0.611111111111111 1.1 1 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00625211720860976 0.020037754026693 1.41838799151574 0.611111111111111 1.1 1 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 8.63861354948501e-07 1.21710367137794e-05 1.41620249384007 0.610169491525424 1.1 1 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 8.63861354948501e-07 1.21710367137794e-05 1.41620249384007 0.610169491525424 1.1 1 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00216382007976726 0.00816741637535495 1.41278171486944 0.608695652173913 1.1 1 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 4.80368263636482e-06 4.55709359436476e-05 1.40135760396753 0.60377358490566 1.1 1 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.000234638159330934 0.00124585858480567 1.39259911894273 0.6 1.1 1 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00184671515290932 0.00703488850942934 1.39259911894273 0.6 1.1 1 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0053002610491579 0.0174589617429437 1.39259911894273 0.6 1.1 1 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0156140917766205 0.041686402623135 1.39259911894273 0.6 1.1 1 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0481480098464711 0.10195627680287 1.39259911894273 0.6 1.1 1 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 7.29073359937521e-05 0.00043408844819711 1.38154674498287 0.595238095238095 1.1 1 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000201044565477226 0.0010961165389812 1.38005318093424 0.594594594594595 1.1 1 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.73801555789256e-13 6.88199758680069e-11 1.37602055800294 0.592857142857143 1.1 1 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 8.38845272931269e-06 6.45230715341187e-05 1.37540653722739 0.592592592592593 1.1 1 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.00447263881028907 0.0149754471224502 1.37149913229208 0.590909090909091 1.1 1 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.53693141485781e-12 1.04145400159174e-10 1.3692221553154 0.589928057553957 1.1 1 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 8.45541843485894e-07 1.2153596396772e-05 1.36529325386542 0.588235294117647 1.1 1 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0130280622164861 0.0359979272506015 1.36529325386542 0.588235294117647 1.1 1 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 5.26619145867528e-14 4.99586029712995e-12 1.36358663729809 0.5875 1.1 1 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.28071672805278e-06 2.49650761847623e-05 1.36312612171643 0.587301587301587 1.1 1 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 5.33795851224581e-05 0.000333154165040604 1.36232522505267 0.58695652173913 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00132922884709709 0.00557962433456978 1.36058534609347 0.586206896551724 1.1 1 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00132922884709709 0.00557962433456978 1.36058534609347 0.586206896551724 1.1 1 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.000146358396086771 0.000829752978611453 1.3586332867734 0.585365853658537 1.1 1 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.95369881266453e-06 2.15512667474544e-05 1.35689144922625 0.584615384615385 1.1 1 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 6.21359988538365e-07 9.02240064989891e-06 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 5.27390874046663e-06 4.78010964183696e-05 1.35391581008321 0.583333333333333 1.1 1 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000403786952835803 0.0019813408065012 1.35391581008321 0.583333333333333 1.1 1 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00376187052029121 0.0130246757916652 1.35391581008321 0.583333333333333 1.1 1 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00376187052029121 0.0130246757916652 1.35391581008321 0.583333333333333 1.1 1 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0393358597318841 0.0863810623433195 1.35391581008321 0.583333333333333 1.1 1 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.67105211881906e-06 1.85773997271838e-05 1.35102899598922 0.582089552238806 1.1 1 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.67105211881906e-06 1.85773997271838e-05 1.35102899598922 0.582089552238806 1.1 1 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 4.50303610709642e-06 4.32960836513392e-05 1.34767656671877 0.580645161290323 1.1 1 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.0495001803345e-12 8.58377466018498e-11 1.34373599196228 0.578947368421053 1.1 1 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.54167303232331e-07 6.80294813157481e-06 1.34373599196228 0.578947368421053 1.1 1 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000342083105660654 0.00170204286487801 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.010840808511391 0.0308529410234188 1.34373599196228 0.578947368421053 1.1 1 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 6.90083898413897e-18 1.09109931938108e-15 1.34264040615555 0.57847533632287 1.1 1 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.86798431666016e-10 7.59469052173547e-09 1.33976338001265 0.577235772357724 1.1 1 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 3.87609126154579e-07 5.9629116791474e-06 1.33903761436801 0.576923076923077 1.1 1 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 4.77914245179239e-09 1.17253788084493e-07 1.33903761436801 0.576923076923077 1.1 1 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 3.29445986733307e-05 0.000223238875772141 1.33903761436801 0.576923076923077 1.1 1 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00315652181807393 0.0111734590724358 1.33903761436801 0.576923076923077 1.1 1 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 1.2375996716696e-07 2.17420287998252e-06 1.33798738878811 0.576470588235294 1.1 1 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000946755564620326 0.00421010365142101 1.33633248787434 0.575757575757576 1.1 1 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000289296459558747 0.0014702459355432 1.33457415565345 0.575 1.1 1 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.000289296459558747 0.0014702459355432 1.33457415565345 0.575 1.1 1 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000289296459558747 0.0014702459355432 1.33457415565345 0.575 1.1 1 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.36522517537906e-10 5.71386889577767e-09 1.33411726617873 0.574803149606299 1.1 1 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.0857901889201e-12 8.58377466018498e-11 1.32837022876089 0.572327044025157 1.1 1 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 2.74129033285873e-11 1.5003292860223e-09 1.32628487518355 0.571428571428571 1.1 1 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 2.4544109976333e-08 4.98946692804597e-07 1.32628487518355 0.571428571428571 1.1 1 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.5775607198574e-05 0.000447421946238883 1.32628487518355 0.571428571428571 1.1 1 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00079690235384653 0.00359997476039242 1.32628487518355 0.571428571428571 1.1 1 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00079690235384653 0.00359997476039242 1.32628487518355 0.571428571428571 1.1 1 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00900587076447347 0.0269230128106003 1.32628487518355 0.571428571428571 1.1 1 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00900587076447347 0.0269230128106003 1.32628487518355 0.571428571428571 1.1 1 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0321343986224452 0.0722389403471398 1.32628487518355 0.571428571428571 1.1 1 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 2.08920067758721e-08 4.30859791914e-07 1.32296916299559 0.57 1.1 1 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.03663842270313e-07 3.49173069338139e-06 1.32242939589523 0.569767441860465 1.1 1 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.000206033037923659 0.00111477191241585 1.31874916566547 0.568181818181818 1.1 1 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 3.97629729155125e-12 2.47199214833958e-10 1.31572528222827 0.56687898089172 1.1 1 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.000173580998436573 0.000961111909631296 1.31186873523591 0.565217391304348 1.1 1 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00747410315996743 0.0231713481408141 1.31186873523591 0.565217391304348 1.1 1 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00747410315996743 0.0231713481408141 1.31186873523591 0.565217391304348 1.1 1 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00747410315996743 0.0231713481408141 1.31186873523591 0.565217391304348 1.1 1 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.89705401377869e-07 5.9629116791474e-06 1.31068152371081 0.564705882352941 1.1 1 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.89705401377869e-07 5.9629116791474e-06 1.31068152371081 0.564705882352941 1.1 1 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0262700978922745 0.0625122898005128 1.30556167400881 0.5625 1.1 1 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0262700978922745 0.0625122898005128 1.30556167400881 0.5625 1.1 1 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.0262700978922745 0.0625122898005128 1.30556167400881 0.5625 1.1 1 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 2.79564366493368e-07 4.62581504093097e-06 1.30393175930967 0.561797752808989 1.1 1 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 8.74555817076076e-07 1.22009110558751e-05 1.30202356649117 0.560975609756098 1.1 1 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000471939540661828 0.00228425158626456 1.30202356649117 0.560975609756098 1.1 1 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.06506899538109e-08 4.30859791914e-07 1.3014945036848 0.560747663551402 1.1 1 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.74356238660205e-06 2.93540547077799e-05 1.29975917767988 0.56 1.1 1 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00619934098786816 0.0200037692193569 1.29975917767988 0.56 1.1 1 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00619934098786816 0.0200037692193569 1.29975917767988 0.56 1.1 1 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00619934098786816 0.0200037692193569 1.29975917767988 0.56 1.1 1 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 2.24554407322096e-25 7.98852304048358e-23 1.29702859117215 0.558823529411765 1.1 1 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000395665595912868 0.00194820810721111 1.29544104087696 0.558139534883721 1.1 1 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000103290107342401 0.000597487084342423 1.29440302722241 0.557692307692308 1.1 1 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.64901023014712e-06 1.85773997271838e-05 1.28944362865068 0.555555555555556 1.1 1 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 1.64901023014712e-06 1.85773997271838e-05 1.28944362865068 0.555555555555556 1.1 1 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.000331522998863142 0.00166698666919523 1.28944362865068 0.555555555555556 1.1 1 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.000331522998863142 0.00166698666919523 1.28944362865068 0.555555555555556 1.1 1 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 1.2075709046429e-07 2.14796674663356e-06 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.13564856636739e-06 4.9050718595173e-05 1.28944362865068 0.555555555555556 1.1 1 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00128829660510994 0.00551097930488208 1.28944362865068 0.555555555555556 1.1 1 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0051405001184846 0.0169719992310988 1.28944362865068 0.555555555555556 1.1 1 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0051405001184846 0.0169719992310988 1.28944362865068 0.555555555555556 1.1 1 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0051405001184846 0.0169719992310988 1.28944362865068 0.555555555555556 1.1 1 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0214979934763316 0.0541445039235749 1.28944362865068 0.555555555555556 1.1 1 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605547 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.100150695859756 0.181316081690118 1.28944362865068 0.555555555555556 1.1 1 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00107481973872917 0.00472058175373955 1.28265708323673 0.552631578947368 1.1 1 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 7.2614071945168e-08 1.37773099170632e-06 1.2820753793441 0.552380952380952 1.1 1 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 6.44238684832806e-18 1.09109931938108e-15 1.27996242549883 0.551470588235294 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00089644628395753 0.00400978020595041 1.27654919236417 0.55 1.1 1 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0176125887430093 0.0458184895453422 1.27654919236417 0.55 1.1 1 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.1473384460355e-05 8.77775596079845e-05 1.27491468635602 0.549295774647887 1.1 1 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.00353378158848641 0.0124162251862127 1.27280564634551 0.548387096774194 1.1 1 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 4.95757408564499e-07 7.34857075403418e-06 1.27044130149161 0.547368421052632 1.1 1 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 3.60665211890813e-05 0.000240951453765552 1.26929607195301 0.546875 1.1 1 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.99548976892553e-12 2.47199214833958e-10 1.26830520850886 0.546448087431694 1.1 1 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.000623224665499917 0.00291726545725783 1.26599919903885 0.545454545454545 1.1 1 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0029302490096237 0.0104767445746093 1.26599919903885 0.545454545454545 1.1 1 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0144457491094948 0.0394554721359137 1.26599919903885 0.545454545454545 1.1 1 1 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.0794594106954205 0.153212386747403 1.26599919903885 0.545454545454545 1.1 1 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 1.2927985819414e-06 1.7033818352802e-05 1.26365475607766 0.544444444444444 1.1 1 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00243017616524962 0.00898218359259793 1.25997063142438 0.542857142857143 1.1 1 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0118612871886757 0.0329660384169638 1.25720753793441 0.541666666666667 1.1 1 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0118612871886757 0.0329660384169638 1.25720753793441 0.541666666666667 1.1 1 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.36570464622209e-06 3.28040939148906e-05 1.25606979355619 0.541176470588235 1.1 1 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.39635792220242e-07 7.91651270442685e-06 1.25333920704846 0.54 1.1 1 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000361012917060243 0.00178996996856002 1.25333920704846 0.54 1.1 1 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.89386976678268e-09 9.72101171602062e-08 1.25233733717872 0.539568345323741 1.1 1 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 2.75084291120515e-09 7.38575370310363e-08 1.24976844007681 0.538461538461538 1.1 1 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0097492966859614 0.0283127534369859 1.24976844007681 0.538461538461538 1.1 1 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0097492966859614 0.0283127534369859 1.24976844007681 0.538461538461538 1.1 1 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.0634937585161931 0.127795782699495 1.24976844007681 0.538461538461538 1.1 1 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0634937585161931 0.127795782699495 1.24976844007681 0.538461538461538 1.1 1 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0634937585161931 0.127795782699495 1.24976844007681 0.538461538461538 1.1 1 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 1.19021452065307e-08 2.60565425059896e-07 1.24841587682997 0.537878787878788 1.1 1 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 1.66355374267043e-06 1.85773997271838e-05 1.24784867288775 0.537634408602151 1.1 1 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 4.6468873898715e-05 0.000292589413972882 1.24710368860543 0.537313432835821 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00138798040777361 0.00565930120418866 1.24541384620895 0.536585365853659 1.1 1 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 3.88370274221615e-05 0.000257046930333655 1.24459341548022 0.536231884057971 1.1 1 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 3.88370274221615e-05 0.000257046930333655 1.24459341548022 0.536231884057971 1.1 1 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00802114308936341 0.024652454894523 1.24339207048458 0.535714285714286 1.1 1 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.00802114308936341 0.024652454894523 1.24339207048458 0.535714285714286 1.1 1 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 4.29439073115145e-06 4.15708708192415e-05 1.23962421572554 0.534090909090909 1.1 1 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 2.26675863908562e-05 0.000156582405020332 1.23786588350465 0.533333333333333 1.1 1 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0066052952619423 0.0210275954311944 1.23786588350465 0.533333333333333 1.1 1 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0066052952619423 0.0210275954311944 1.23786588350465 0.533333333333333 1.1 1 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0510147493033876 0.106599101701499 1.23786588350465 0.533333333333333 1.1 1 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.000121161426333602 0.000695212539002884 1.23537018615887 0.532258064516129 1.1 1 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.000794442473975419 0.00359997476039242 1.23457368700597 0.531914893617021 1.1 1 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.58297082693242e-05 0.000118037332696519 1.23394858640495 0.531645569620253 1.1 1 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.58297082693242e-05 0.000118037332696519 1.23394858640495 0.531645569620253 1.1 1 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.00544394476204805 0.0177677371476935 1.23303046989721 0.53125 1.1 1 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.0411673880275365 0.0889620417504222 1.22876392847888 0.529411764705882 1.1 1 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 5.85822307669256e-05 0.00035777903167955 1.22681350954479 0.528571428571429 1.1 1 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00370639449717041 0.0129906388410677 1.22497144721814 0.527777777777778 1.1 1 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 8.20522654196701e-08 1.4969278678486e-06 1.22446379224623 0.52755905511811 1.1 1 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00306141405252049 0.0108638209394929 1.22157817451117 0.526315789473684 1.1 1 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.00306141405252049 0.0108638209394929 1.22157817451117 0.526315789473684 1.1 1 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0333393101040433 0.074476983168059 1.22157817451117 0.526315789473684 1.1 1 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.87218694410833e-09 9.72101171602062e-08 1.22001204864641 0.525641025641026 1.1 1 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.24394175888143e-09 8.54838726460791e-08 1.21925872228108 0.525316455696203 1.1 1 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00253026443692828 0.00918511809629834 1.21852422907489 0.525 1.1 1 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00209249621086264 0.00791920773419559 1.21576113558492 0.523809523809524 1.1 1 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.00209249621086264 0.00791920773419559 1.21576113558492 0.523809523809524 1.1 1 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0270799785193987 0.0642246823885072 1.21576113558492 0.523809523809524 1.1 1 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.0270799785193987 0.0642246823885072 1.21576113558492 0.523809523809524 1.1 1 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 1.07294674303657e-06 1.46808001475099e-05 1.21373317706018 0.522935779816514 1.1 1 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00143337851765576 0.00575861758488461 1.21095575560237 0.521739130434783 1.1 1 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0220511810544337 0.0543925739540424 1.21095575560237 0.521739130434783 1.1 1 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 6.67056571974044e-06 5.27345278843925e-05 1.20988221326585 0.521276595744681 1.1 1 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.00118721334120979 0.00513496834207153 1.20885340186001 0.520833333333333 1.1 1 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00098376683986993 0.00435235897457334 1.20691923641703 0.52 1.1 1 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0179950622395505 0.0464736362375325 1.20691923641703 0.52 1.1 1 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 2.70592876646765e-06 2.91707320809354e-05 1.20513385293121 0.519230769230769 1.1 1 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 4.18785067426061e-05 0.000275894051364484 1.20456885815721 0.518987341772152 1.1 1 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.97542426039187e-10 1.52892668176693e-08 1.20394041477224 0.518716577540107 1.1 1 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 3.48944047482117e-05 0.000234220462059931 1.20348072007397 0.518518518518518 1.1 1 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 3.48944047482117e-05 0.000234220462059931 1.20348072007397 0.518518518518518 1.1 1 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.000676330694937205 0.00311656061738434 1.20348072007397 0.518518518518518 1.1 1 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0147126160663211 0.0399542989739979 1.20348072007397 0.518518518518518 1.1 1 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.0147126160663211 0.0399542989739979 1.20348072007397 0.518518518518518 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0147126160663211 0.0399542989739979 1.20348072007397 0.518518518518518 1.1 1 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 1.5759083334102e-06 1.82318500686399e-05 1.2026992390869 0.518181818181818 1.1 1 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.74811007933427e-08 3.71277707894428e-07 1.19793472597224 0.516129032258065 1.1 1 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00988157651362854 0.0286384590201495 1.19793472597224 0.516129032258065 1.1 1 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.61721586761972e-11 9.20519271849144e-10 1.1969274938596 0.515695067264574 1.1 1 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.6085403107136e-07 4.36700336722995e-06 1.19620693550209 0.515384615384615 1.1 1 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 8.55207695913031e-09 1.90150086138163e-07 1.1960974027729 0.515337423312883 1.1 1 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00452341841662771 0.0151099164480311 1.19025565721601 0.512820512820513 1.1 1 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 7.22960328752902e-09 1.65931056099255e-07 1.18780513086292 0.511764705882353 1.1 1 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.15179093459994e-07 4.99190070198858e-06 1.18667594095371 0.511278195488722 1.1 1 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 2.036213352139e-05 0.000145604603019789 1.18572751069399 0.510869565217391 1.1 1 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00143661928505554 0.00575861758488461 1.18325415335003 0.509803921568627 1.1 1 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 8.27264715896178e-11 3.67874278350081e-09 1.18159925243626 0.509090909090909 1.1 1 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.000984862677310342 0.00435235897457334 1.18159925243626 0.509090909090909 1.1 1 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 1.24222339107605e-08 2.67830891742608e-07 1.18109984446819 0.50887573964497 1.1 1 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.000816023975130203 0.00367469024243759 1.18085890202746 0.508771929824561 1.1 1 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 3.54279906242809e-09 9.16618739242759e-08 1.17952384391324 0.508196721311475 1.1 1 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.00056093505157369 0.00268757770501468 1.17952384391324 0.508196721311475 1.1 1 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.000465342104783324 0.00226000619490331 1.17891988905205 0.507936507936508 1.1 1 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000386178950645097 0.00190809946794435 1.17835310064385 0.507692307692308 1.1 1 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 3.41654460401157e-19 6.94534710215494e-17 1.1768443258671 0.507042253521127 1.1 1 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.000105585796996755 0.000608293883102765 1.17518912990948 0.506329113924051 1.1 1 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 6.07955841936084e-05 0.000368136665138318 1.17415219832426 0.505882352941176 1.1 1 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 5.05215019168396e-09 1.21851012250276e-07 1.1731133882398 0.505434782608696 1.1 1 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.46639057157093e-09 6.74937266027968e-08 1.17258779980421 0.505208333333333 1.1 1 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 6.78945370047713e-06 5.33778597556849e-05 1.17114604804052 0.504587155963303 1.1 1 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.10766645836673e-06 1.50115178119605e-05 1.16949538412503 0.503875968992248 1.1 1 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 2.69719006260753e-06 2.91707320809354e-05 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 8.01728230750082e-06 6.20032213237699e-05 1.16049926578561 0.5 1.1 1 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00116637853079607 0.00508825764701246 1.16049926578561 0.5 1.1 1 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00301297543743459 0.0107455239284948 1.16049926578561 0.5 1.1 1 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0143192082652091 0.0391850641565241 1.16049926578561 0.5 1.1 1 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0143192082652091 0.0391850641565241 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0214040890432787 0.0541445039235749 1.16049926578561 0.5 1.1 1 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0214040890432787 0.0541445039235749 1.16049926578561 0.5 1.1 1 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0214040890432787 0.0541445039235749 1.16049926578561 0.5 1.1 1 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.0322410749201916 0.0722504718290278 1.16049926578561 0.5 1.1 1 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.0322410749201916 0.0722504718290278 1.16049926578561 0.5 1.1 1 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.0397142079293025 0.0865441315212825 1.16049926578561 0.5 1.1 1 1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.0757594007145008 0.148009357515324 1.16049926578561 0.5 1.1 1 1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0948531184099409 0.175066131643769 1.16049926578561 0.5 1.1 1 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0948531184099409 0.175066131643769 1.16049926578561 0.5 1.1 1 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.119582961658957 0.21112475737059 1.16049926578561 0.5 1.1 1 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000217337316760709 0.00116267293891161 1.16049926578561 0.5 1.1 1 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000217337316760709 0.00116267293891161 1.16049926578561 0.5 1.1 1 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.00963679848263036 0.0283127534369859 1.16049926578561 0.5 1.1 1 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00963679848263036 0.0283127534369859 1.16049926578561 0.5 1.1 1 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0174921851388692 0.0458184895453422 1.16049926578561 0.5 1.1 1 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0262408277931396 0.0625122898005128 1.16049926578561 0.5 1.1 1 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0490660314650774 0.103591932900304 1.16049926578561 0.5 1.1 1 1 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.0490660314650774 0.103591932900304 1.16049926578561 0.5 1.1 1 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0608367825787413 0.123144724906897 1.16049926578561 0.5 1.1 1 1 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605609 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 48%5605501 INTERACTION BETWEEN L1 AND ANKYRINS 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.15215338187304 0.258062291305526 1.16049926578561 0.5 1.1 1 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.13866368726958e-11 1.6541920099943e-09 1.15157234835649 0.496153846153846 1.1 1 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 6.41927363190546e-11 2.94665367038757e-09 1.15128895415239 0.496031746031746 1.1 1 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 6.41927363190546e-11 2.94665367038757e-09 1.15128895415239 0.496031746031746 1.1 1 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 6.41927363190546e-11 2.94665367038757e-09 1.15128895415239 0.496031746031746 1.1 1 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 4.53892172079602e-06 4.33482255616962e-05 1.15106431240524 0.495934959349593 1.1 1 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 5.44184608141459e-06 4.90110567965377e-05 1.15090836276259 0.495867768595041 1.1 1 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.09624641799668e-30 7.79979326404638e-28 1.15009786391557 0.495518565941101 1.1 1 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 1.9438764995893e-05 0.000139703851460382 1.1496534782549 0.495327102803738 1.1 1 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.69178205723832e-21 1.05068117349002e-18 1.14745994819251 0.49438202247191 1.1 1 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000175379839171647 0.000967308182718036 1.14651734692072 0.493975903614458 1.1 1 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.000253772860707028 0.00133747696587445 1.14580940166174 0.493670886075949 1.1 1 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.000442608968133327 0.00215696082758125 1.14460201556937 0.493150684931507 1.1 1 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.57911152555721e-06 5.92586576970764e-05 1.14147468765798 0.491803278688525 1.1 1 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.0013584928142407 0.00565930120418866 1.14147468765798 0.491803278688525 1.1 1 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0013584928142407 0.00565930120418866 1.14147468765798 0.491803278688525 1.1 1 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.00239361384240944 0.00887008462955372 1.13939927913496 0.490909090909091 1.1 1 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.00248212047486e-10 4.32282441647192e-09 1.13826747908474 0.490421455938697 1.1 1 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 5.6129885490601e-05 0.000344279426953126 1.1372892804699 0.49 1.1 1 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0042384285086095 0.014360199447027 1.13681560730019 0.489795918367347 1.1 1 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00513440279463064 0.0169719992310988 1.13580779204549 0.48936170212766 1.1 1 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.000202629781406813 0.00110054266771716 1.13351091076734 0.488372093023256 1.1 1 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 1.3060842447585e-11 7.74399116788058e-10 1.13277402735387 0.488054607508532 1.1 1 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 1.50512991088302e-05 0.000114534752042061 1.13124298177421 0.487394957983193 1.1 1 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0111473908177767 0.0312874499678427 1.13074287435521 0.487179487179487 1.1 1 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0111473908177767 0.0312874499678427 1.13074287435521 0.487179487179487 1.1 1 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0111473908177767 0.0312874499678427 1.13074287435521 0.487179487179487 1.1 1 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.000510147470994763 0.00246081305500186 1.12995981142283 0.486842105263158 1.1 1 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 2.04866164042054e-19 4.85874252386405e-17 1.12961145262782 0.486692015209125 1.1 1 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000614095961441006 0.00289357136798196 1.12913442076438 0.486486486486487 1.1 1 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000614095961441006 0.00289357136798196 1.12913442076438 0.486486486486487 1.1 1 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0135645195432629 0.0373352249711086 1.12913442076438 0.486486486486487 1.1 1 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00089065762632373 0.00399812555917561 1.12734214390602 0.485714285714286 1.1 1 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0165252668499343 0.0439541209859001 1.12734214390602 0.485714285714286 1.1 1 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.0165252668499343 0.0439541209859001 1.12734214390602 0.485714285714286 1.1 1 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0201587016922304 0.0515932239353307 1.12533262136786 0.484848484848485 1.1 1 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00155964429013411 0.00618209979069871 1.12423366372981 0.484375 1.1 1 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 2.60933512830987e-16 2.85621837506534e-14 1.12407103771162 0.484304932735426 1.1 1 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0246271307250323 0.0601104751659021 1.12306380559898 0.483870967741935 1.1 1 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0246271307250323 0.0601104751659021 1.12306380559898 0.483870967741935 1.1 1 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.00227028299416121 0.00852404406514883 1.12181595692609 0.483333333333333 1.1 1 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0301357479632936 0.0693902416695256 1.12048204972404 0.482758620689655 1.1 1 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0301357479632936 0.0693902416695256 1.12048204972404 0.482758620689655 1.1 1 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0301357479632936 0.0693902416695256 1.12048204972404 0.482758620689655 1.1 1 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.000334702388694995 0.00167116315478238 1.11954046816965 0.482352941176471 1.1 1 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.000334702388694995 0.00167116315478238 1.11954046816965 0.482352941176471 1.1 1 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 5.10612335425858e-05 0.000320088701899117 1.11829929248431 0.481818181818182 1.1 1 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0369455958251854 0.0817629593456281 1.11751781149725 0.481481481481481 1.1 1 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.25146116840626e-06 1.66432639499263e-05 1.11698054331865 0.48125 1.1 1 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 1.63341279302075e-05 0.000120432456190079 1.11481031831374 0.480314960629921 1.1 1 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 4.0590723424023e-07 6.14474462046647e-06 1.11460381459635 0.480225988700565 1.1 1 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0453912404715525 0.0978662654409382 1.11407929515419 0.48 1.1 1 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00708611596325099 0.0224078733682359 1.11214512971121 0.479166666666667 1.1 1 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.8799669748139e-09 5.24547648070622e-08 1.11043851314388 0.47843137254902 1.1 1 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00146809973212266 0.00585183730759258 1.11004277596884 0.478260869565217 1.1 1 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00146809973212266 0.00585183730759258 1.11004277596884 0.478260869565217 1.1 1 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00858473620102299 0.0258268067950438 1.11004277596884 0.478260869565217 1.1 1 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.00858473620102299 0.0258268067950438 1.11004277596884 0.478260869565217 1.1 1 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.0559053158979323 0.116476229169484 1.11004277596884 0.478260869565217 1.1 1 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.1323572207192e-16 1.34278693756952e-14 1.1065770776784 0.476767676767677 1.1 1 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.90467484059296e-08 1.32775031056267e-06 1.10523739598629 0.476190476190476 1.1 1 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.00256813679081634 0.00929887698048767 1.10523739598629 0.476190476190476 1.1 1 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00373526944246464 0.0130246757916652 1.10149082854227 0.474576271186441 1.1 1 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0855845078059697 0.16066854169907 1.09942035706005 0.473684210526316 1.1 1 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00544198981649656 0.0177677371476935 1.09719930583367 0.472727272727273 1.1 1 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00544198981649656 0.0177677371476935 1.09719930583367 0.472727272727273 1.1 1 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00544198981649656 0.0177677371476935 1.09719930583367 0.472727272727273 1.1 1 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00164850735349028 0.00639189635971844 1.09602708435308 0.472222222222222 1.1 1 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.022688633283838 0.0558580020119402 1.09602708435308 0.472222222222222 1.1 1 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 2.82223538603675e-08 5.65639571032436e-07 1.09575037971173 0.472103004291845 1.1 1 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 9.82136128731735e-16 9.98271222275185e-14 1.09445459212301 0.471544715447154 1.1 1 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.0276427046281272 0.06501746890219 1.09223460309234 0.470588235294118 1.1 1 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.106507856436247 0.190882468147077 1.09223460309234 0.470588235294118 1.1 1 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0337223564248763 0.0750968907552409 1.08796806167401 0.46875 1.1 1 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.0337223564248763 0.0750968907552409 1.08796806167401 0.46875 1.1 1 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00416456534193699 0.0141436192877717 1.08562834541234 0.467741935483871 1.1 1 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 3.09154093011099e-07 4.99190070198858e-06 1.08313264806657 0.466666666666667 1.1 1 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.09154093011099e-07 4.99190070198858e-06 1.08313264806657 0.466666666666667 1.1 1 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00501713258473011 0.0167198587074261 1.08313264806657 0.466666666666667 1.1 1 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.041198865434665 0.0889620417504222 1.08313264806657 0.466666666666667 1.1 1 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.133211691378176 0.23060856062183 1.08313264806657 0.466666666666667 1.1 1 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 5.45454503940146e-17 7.05619781006207e-15 1.08123574325384 0.46584938704028 1.1 1 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00604627915480525 0.0196435051079632 1.08046483366246 0.46551724137931 1.1 1 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0170436285482207 0.045080080713974 1.0795342007308 0.465116279069767 1.1 1 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0170436285482207 0.045080080713974 1.0795342007308 0.465116279069767 1.1 1 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.000165155298006498 0.0009252597994616 1.0790607208182 0.464912280701754 1.1 1 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00264649214497638 0.00955826985355683 1.07877396537817 0.464788732394366 1.1 1 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00117283802404785 0.00508825764701246 1.07760646108664 0.464285714285714 1.1 1 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00117283802404785 0.00508825764701246 1.07760646108664 0.464285714285714 1.1 1 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00728913038725041 0.0228618899768883 1.07760646108664 0.464285714285714 1.1 1 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.0504149017028378 0.105968102102124 1.07760646108664 0.464285714285714 1.1 1 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00140627911298146 0.00571140014254978 1.07558468536227 0.463414634146341 1.1 1 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00879077047440703 0.026390857352492 1.0745363572089 0.462962962962963 1.1 1 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 1.02189468121656e-27 4.84718710457055e-25 1.07337469628219 0.462462462462462 1.1 1 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0618058799101924 0.124928646466199 1.07123009149441 0.461538461538462 1.1 1 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.167659421495612 0.275178035511252 1.07123009149441 0.461538461538462 1.1 1 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00552622498848109 0.0179950072279373 1.06839614945342 0.46031746031746 1.1 1 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.000576648613175972 0.00275359388103828 1.06765932452276 0.46 1.1 1 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0128014431561703 0.0354738135115225 1.06765932452276 0.46 1.1 1 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00128963886755146 0.00551097930488208 1.06712576164194 0.459770114942529 1.1 1 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00128963886755146 0.00551097930488208 1.06712576164194 0.459770114942529 1.1 1 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00349094081469535 0.0122960613349294 1.06379099363681 0.458333333333333 1.1 1 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0154582642132153 0.041686402623135 1.06379099363681 0.458333333333333 1.1 1 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0759289044175591 0.148009357515324 1.06379099363681 0.458333333333333 1.1 1 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0759289044175591 0.148009357515324 1.06379099363681 0.458333333333333 1.1 1 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.0759289044175591 0.148009357515324 1.06379099363681 0.458333333333333 1.1 1 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 2.66301022479609e-05 0.000183065871975113 1.06316706930036 0.458064516129032 1.1 1 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00184894469608333 0.00703488850942934 1.0626258337314 0.457831325301205 1.1 1 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00799619359959263 0.024652454894523 1.06215187038005 0.457627118644068 1.1 1 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00140878527760715 0.00571140014254978 1.05734377549356 0.455555555555556 1.1 1 1 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_196540.2 DERMATAN SULFATE BIOSYNTHESIS 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%REACT_215414.1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.212731691187723 0.331928561315588 1.05499933253237 0.454545454545455 1.1 1 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000898889589387337 0.00400978020595041 1.05499933253237 0.454545454545455 1.1 1 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.0139434288150738 0.0383040525170849 1.05101820297565 0.452830188679245 1.1 1 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 4.46597295564104e-05 0.000286078396676838 1.04962353975514 0.452229299363057 1.1 1 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00152980293431257 0.00608075300426478 1.04819288522571 0.451612903225806 1.1 1 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0548461763720094 0.114437109937492 1.04819288522571 0.451612903225806 1.1 1 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 4.60838672912693e-37 6.55773431554762e-34 1.04587280505921 0.450613298902518 1.1 1 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.0330335959359395 0.0739100739258522 1.04444933920705 0.45 1.1 1 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.11546326117579 0.205637322469524 1.04444933920705 0.45 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.11546326117579 0.205637322469524 1.04444933920705 0.45 1.1 1 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0202274080122622 0.0516761249577183 1.04208097335851 0.448979591836735 1.1 1 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.0668917141162175 0.134444786987821 1.04044761760089 0.448275862068966 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00782328382743292 0.0242011584487762 1.03925307383786 0.447761194029851 1.1 1 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.0180655554876072 0.046571169309538 1.03155490292054 0.444444444444444 1.1 1 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.0293768703293194 0.0679728235424739 1.03155490292054 0.444444444444444 1.1 1 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.0816941071781977 0.156461257758513 1.03155490292054 0.444444444444444 1.1 1 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00702414124895317 0.0222613652500231 1.03155490292054 0.444444444444444 1.1 1 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.143044715522251 0.246133772899834 1.03155490292054 0.444444444444444 1.1 1 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.26659388165655e-05 0.000156582405020332 1.02752539158101 0.442708333333333 1.1 1 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0216975988925327 0.0543925739540424 1.02659550434881 0.442307692307692 1.1 1 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0587485841990627 0.119908982842123 1.02396994039907 0.441176470588235 1.1 1 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0999227832322783 0.181316081690118 1.02123935389134 0.44 1.1 1 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.0999227832322783 0.181316081690118 1.02123935389134 0.44 1.1 1 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.177896806338811 0.289973832096367 1.01543685756241 0.4375 1.1 1 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.122423657338782 0.215605030189463 1.00912979633531 0.434782608695652 1.1 1 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00122663867611143 0.0052894146548684 1.00830264076455 0.434426229508197 1.1 1 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.0865391866374049 0.162246722773422 1.00576603034753 0.433333333333333 1.1 1 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 4.99406570393662e-17 7.05619781006207e-15 1.00296542880114 0.432126696832579 1.1 1 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00632107901272557 0.0202132481687831 1.00224936590575 0.431818181818182 1.1 1 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.024392149771522 0.0597418745694936 1.00043040153932 0.431034482758621 1.1 1 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.024392149771522 0.0597418745694936 1.00043040153932 0.431034482758621 1.1 1 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.024392149771522 0.0597418745694936 1.00043040153932 0.431034482758621 1.1 1 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0134332245419962 0.0370455010140709 0.999318812204275 0.430555555555556 1.1 1 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000220345960407493 0.00117435318973731 0.998569135675989 0.430232558139535 1.1 1 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.105153511284718 0.189890160606794 0.994713656387665 0.428571428571429 1.1 1 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.150270692814044 0.25701345657979 0.994713656387665 0.428571428571429 1.1 1 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.150270692814044 0.25701345657979 0.994713656387665 0.428571428571429 1.1 1 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.150270692814044 0.25701345657979 0.994713656387665 0.428571428571429 1.1 1 1 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.222264148809865 0.336112522589201 0.994713656387665 0.428571428571429 1.1 1 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.00143619375782141 0.00575861758488461 0.99218257838159 0.427480916030534 1.1 1 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.00143619375782141 0.00575861758488461 0.99218257838159 0.427480916030534 1.1 1 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.000422009769905391 0.00206364227689131 0.990670104938935 0.426829268292683 1.1 1 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0256193169274443 0.0622106856979582 0.989278062636913 0.426229508196721 1.1 1 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.0167406155977205 0.044443835812605 0.985629513406956 0.424657534246575 1.1 1 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 2.14857561355686e-05 0.00015287115490457 0.983011142783105 0.423529411764706 1.1 1 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.127875179001808 0.221639926576825 0.981960917203208 0.423076923076923 1.1 1 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.000326692611730906 0.00165438998751986 0.97858316466246 0.421621621621622 1.1 1 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.184833957497728 0.300936752310374 0.977262539608934 0.421052631578947 1.1 1 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.0153918949724692 0.041686402623135 0.974246297202734 0.419753086419753 1.1 1 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.109428582940191 0.195870281162127 0.973321964852447 0.419354838709677 1.1 1 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0678552005896511 0.136188928686987 0.971580780657719 0.418604651162791 1.1 1 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0278455873253837 0.0653865854191765 0.969969535582002 0.417910447761194 1.1 1 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00698751873397903 0.0221947302644021 0.967082721488008 0.416666666666667 1.1 1 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.0589176397289481 0.119942491179246 0.967082721488008 0.416666666666667 1.1 1 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0940555952034483 0.174045659264638 0.967082721488008 0.416666666666667 1.1 1 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.155634195139655 0.263338239814184 0.967082721488008 0.416666666666667 1.1 1 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.155634195139655 0.263338239814184 0.967082721488008 0.416666666666667 1.1 1 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.279266497993985 0.407168265005575 0.967082721488008 0.416666666666667 1.1 1 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.081129617233669 0.155589548953519 0.962365244797822 0.414634146341463 1.1 1 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.081129617233669 0.155589548953519 0.962365244797822 0.414634146341463 1.1 1 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.081129617233669 0.155589548953519 0.962365244797822 0.414634146341463 1.1 1 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.00962292755034195 0.0283127534369859 0.959643623630408 0.413461538461538 1.1 1 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.0128134505586244 0.0354738135115225 0.957112796524214 0.412371134020619 1.1 1 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.112926970168732 0.201624941719078 0.955705277705796 0.411764705882353 1.1 1 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.112926970168732 0.201624941719078 0.955705277705796 0.411764705882353 1.1 1 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.227869071270607 0.343493314002196 0.955705277705796 0.411764705882353 1.1 1 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.227869071270607 0.343493314002196 0.955705277705796 0.411764705882353 1.1 1 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.227869071270607 0.343493314002196 0.955705277705796 0.411764705882353 1.1 1 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.000168114985016487 0.000938147543837102 0.950770482812307 0.409638554216867 1.1 1 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.189571652924599 0.308297670984805 0.949499399279135 0.409090909090909 1.1 1 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00216976046734522 0.00816817234135514 0.948212814727266 0.408536585365854 1.1 1 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.15962466588054 0.269769476897873 0.94559199434383 0.407407407407407 1.1 1 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.0473207599206216 0.101872074685393 0.942905653450808 0.40625 1.1 1 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.099389382001885 0.181316081690118 0.93945178658835 0.404761904761905 1.1 1 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0740184678963351 0.146289277522896 0.937326330057607 0.403846153846154 1.1 1 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0740184678963351 0.146289277522896 0.937326330057607 0.403846153846154 1.1 1 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.049513714042509 0.104382244566652 0.928399412628487 0.4 1.1 1 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.162576940071358 0.272250450485422 0.928399412628487 0.4 1.1 1 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.281632453764325 0.40967313401506 0.928399412628487 0.4 1.1 1 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.00765991277664e-08 9.76150692586459e-07 0.927677484624888 0.399688958009331 1.1 1 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.103144135628047 0.186498227444359 0.918728585413607 0.395833333333333 1.1 1 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.164727784868551 0.272250450485422 0.914332754861389 0.393939393939394 1.1 1 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000620803109264491 0.00291552087288241 0.91331711170131 0.393501805054152 1.1 1 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.078126291912997 0.152084423245136 0.913179750126381 0.39344262295082 1.1 1 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000248691600536657 0.001315569321798 0.911312306874589 0.392638036809816 1.1 1 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.121524021473658 0.214285851991345 0.908216816701781 0.391304347826087 1.1 1 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.232738221515482 0.350461893350826 0.908216816701781 0.391304347826087 1.1 1 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.281848206746833 0.40967313401506 0.902610540055474 0.388888888888889 1.1 1 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.0320166812918773 0.0722389403471398 0.899125557275337 0.387387387387387 1.1 1 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0807700651881784 0.155528826471959 0.895242290748899 0.385714285714286 1.1 1 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.16726961605612 0.275178035511252 0.892691742912007 0.384615384615385 1.1 1 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.233337609792133 0.350993043059414 0.892691742912007 0.384615384615385 1.1 1 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.349020920805469 0.478081648109626 0.892691742912007 0.384615384615385 1.1 1 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.1967949558732 0.313593753871853 0.887440615012525 0.382352941176471 1.1 1 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.280810562572851 0.409000440676732 0.884189916789036 0.380952380952381 1.1 1 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.124849168116022 0.219063336903946 0.8803787533546 0.379310344827586 1.1 1 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.124849168116022 0.219063336903946 0.8803787533546 0.379310344827586 1.1 1 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.14468099855348 0.248348686298676 0.875848502479705 0.377358490566038 1.1 1 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.279000637340978 0.407168265005575 0.870374449339207 0.375 1.1 1 1 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.343873842219633 0.478081648109626 0.870374449339207 0.375 1.1 1 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.343873842219633 0.478081648109626 0.870374449339207 0.375 1.1 1 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.343873842219633 0.478081648109626 0.870374449339207 0.375 1.1 1 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.167984770318489 0.275394387284804 0.864685727448101 0.372549019607843 1.1 1 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.19625807866851 0.313088840745841 0.86362736058464 0.372093023255814 1.1 1 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.0566732213279441 0.117559757944117 0.861015584292549 0.370967741935484 1.1 1 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.0566732213279441 0.117559757944117 0.861015584292549 0.370967741935484 1.1 1 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.0566732213279441 0.117559757944117 0.861015584292549 0.370967741935484 1.1 1 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.0499811213233567 0.105211739117066 0.855971089657471 0.368794326241135 1.1 1 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.194590807265621 0.313088840745841 0.852611705475142 0.36734693877551 1.1 1 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.12454756489344 0.219063336903946 0.852012119184371 0.367088607594937 1.1 1 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.192302877729346 0.312382414393676 0.843999466025898 0.363636363636364 1.1 1 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.332947082371852 0.472366598419885 0.843999466025898 0.363636363636364 1.1 1 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.332947082371852 0.472366598419885 0.843999466025898 0.363636363636364 1.1 1 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.164704412494512 0.272250450485422 0.843999466025898 0.363636363636364 1.1 1 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.139715550680904 0.240696402686351 0.836639005566369 0.36046511627907 1.1 1 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.327502481613956 0.466036031336659 0.835559471365639 0.36 1.1 1 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.137024620998996 0.236346709917056 0.830673158667594 0.357894736842105 1.1 1 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.137024620998996 0.236346709917056 0.830673158667594 0.357894736842105 1.1 1 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.137024620998996 0.236346709917056 0.830673158667594 0.357894736842105 1.1 1 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.322157863892382 0.458889529848708 0.828928046989721 0.357142857142857 1.1 1 1 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.419441349691916 0.554707286813751 0.828928046989721 0.357142857142857 1.1 1 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.31693788846173 0.451906428137316 0.823580124105916 0.354838709677419 1.1 1 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.255887382377757 0.381256042400713 0.822020313264807 0.354166666666667 1.1 1 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.311853107173518 0.445102278342946 0.819175952319254 0.352941176470588 1.1 1 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.407149171828194 0.543502130873846 0.819175952319254 0.352941176470588 1.1 1 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.407149171828194 0.543502130873846 0.819175952319254 0.352941176470588 1.1 1 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.407149171828194 0.543502130873846 0.819175952319254 0.352941176470588 1.1 1 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.396248417245365 0.531443447445951 0.812349486049927 0.35 1.1 1 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.396248417245365 0.531443447445951 0.812349486049927 0.35 1.1 1 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.087993180363922 0.164755652181396 0.811101637377039 0.349462365591398 1.1 1 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.353810577195722 0.478081648109626 0.795770925110132 0.342857142857143 1.1 1 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.240058230449238 0.360721079122772 0.791249499399279 0.340909090909091 1.1 1 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.327994548183388 0.466269972092868 0.790127159683819 0.340425531914894 1.1 1 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 5.97342820813421e-05 0.00036325591197329 0.78800730632857 0.339512195121951 1.1 1 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.291307369928047 0.422990191232256 0.773666177190406 0.333333333333333 1.1 1 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.379343063600351 0.509731047689612 0.773666177190406 0.333333333333333 1.1 1 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.274490021108788 0.403511673592774 0.773666177190406 0.333333333333333 1.1 1 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.406120030059028 0.543502130873846 0.773666177190406 0.333333333333333 1.1 1 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.427682626350554 0.56403371389883 0.773666177190406 0.333333333333333 1.1 1 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.440087393572384 0.576652266163447 0.773666177190406 0.333333333333333 1.1 1 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.469799654368874 0.600724085958155 0.773666177190406 0.333333333333333 1.1 1 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.488345797655711 0.616606983197939 0.773666177190406 0.333333333333333 1.1 1 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.488345797655711 0.616606983197939 0.773666177190406 0.333333333333333 1.1 1 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.400701194446264 0.536909415910578 0.757877071533459 0.326530612244898 1.1 1 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.40952227303937 0.546157633116236 0.756847347251484 0.326086956521739 1.1 1 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.493068528611645 0.622018188133307 0.74271953010279 0.32 1.1 1 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.530427255396596 0.650127462902115 0.732946904706701 0.315789473684211 1.1 1 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.554014868308474 0.672091353455207 0.725312041116006 0.3125 1.1 1 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.497812730368927 0.626891606473436 0.722088432044379 0.311111111111111 1.1 1 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.423216032177021 0.559179585689788 0.718684824496672 0.309644670050761 1.1 1 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.446471805989138 0.583508940039696 0.716357571472598 0.308641975308642 1.1 1 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.470851232073425 0.600724085958155 0.715821977026638 0.308411214953271 1.1 1 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.544496997959731 0.661673123908367 0.714153394329606 0.307692307692308 1.1 1 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.462661762840054 0.597972469138417 0.712124549459351 0.306818181818182 1.1 1 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.423657946321807 0.559244209291216 0.711852642414884 0.306701030927835 1.1 1 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.522024719402679 0.640380323887942 0.706390857434719 0.304347826086957 1.1 1 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.564716067664297 0.68274508435539 0.706390857434719 0.304347826086957 1.1 1 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.494059242276842 0.62271594487152 0.706390857434719 0.304347826086957 1.1 1 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.486787303042934 0.615731850871196 0.704588839941263 0.303571428571429 1.1 1 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.507472285247257 0.629176214832699 0.703786651508692 0.303225806451613 1.1 1 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.555845455015428 0.672591906876662 0.703332888354915 0.303030303030303 1.1 1 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.555845455015428 0.672591906876662 0.703332888354915 0.303030303030303 1.1 1 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.555845455015428 0.672591906876662 0.703332888354915 0.303030303030303 1.1 1 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.521509762759732 0.640300597417686 0.700678801983764 0.30188679245283 1.1 1 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.521509762759732 0.640300597417686 0.700678801983764 0.30188679245283 1.1 1 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.546830265342509 0.663941525240947 0.700678801983764 0.30188679245283 1.1 1 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.587932471747123 0.698353845823169 0.696299559471366 0.3 1.1 1 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.587932471747123 0.698353845823169 0.696299559471366 0.3 1.1 1 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.58178632364634 0.693520966464072 0.690026590467119 0.297297297297297 1.1 1 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.618767293896738 0.733754882679215 0.673838283359386 0.290322580645161 1.1 1 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.618767293896738 0.733754882679215 0.673838283359386 0.290322580645161 1.1 1 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.640887179268742 0.75809015469611 0.663142437591777 0.285714285714286 1.1 1 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.641518522613324 0.758206692424219 0.663142437591777 0.285714285714286 1.1 1 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.722149938699927 0.822095490215997 0.653802403259498 0.28169014084507 1.1 1 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.694138806091372 0.792744398930998 0.64683565633952 0.278688524590164 1.1 1 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.671135544716173 0.772278741518129 0.644721814325338 0.277777777777778 1.1 1 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.782212933295681 0.872326805705136 0.640766465771195 0.276073619631902 1.1 1 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.75562056882181 0.85049749278335 0.630394662895887 0.271604938271605 1.1 1 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.726128994262497 0.825964475488036 0.628603768967205 0.270833333333333 1.1 1 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.878603644013286 0.954391591931989 0.62035905452134 0.267281105990783 1.1 1 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.846572208168071 0.926670963248589 0.61438196423944 0.264705882352941 1.1 1 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.858992563104735 0.935230617672562 0.609897424354481 0.262773722627737 1.1 1 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.735126586426458 0.835531255978314 0.605477877801187 0.260869565217391 1.1 1 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.759478172959675 0.85049749278335 0.598967362986121 0.258064516129032 1.1 1 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.897679631453122 0.96845952657907 0.592955829233523 0.255474452554745 1.1 1 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.842582115675684 0.923013356894918 0.588422162933548 0.253521126760563 1.1 1 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.774824196236523 0.864764573525155 0.580249632892805 0.25 1.1 1 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.923256836954066 0.994545404228339 0.580249632892805 0.25 1.1 1 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.932419723640196 1 0.558758905748627 0.240740740740741 1.1 1 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.851755384010028 0.928825725336522 0.549710178530025 0.236842105263158 1.1 1 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.847584017833637 0.927065378460619 0.546117301546169 0.235294117647059 1.1 1 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.938509518568787 1 0.541566324033284 0.233333333333333 1.1 1 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999997514 1 0.496939232200387 0.214105793450882 1.1 1 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.944999718006551 1 0.483541360744004 0.208333333333333 1.1 1 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.925324721051481 0.996018969785369 0.464199706314244 0.2 1.1 1 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.939008159979998 1 0.449225522239591 0.193548387096774 1.1 1 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.991116427726639 1 0.440695923716054 0.189873417721519 1.1 1 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.440695923716054 0.189873417721519 1.1 1 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.953838694360448 1 0.414464023494861 0.178571428571429 1.1 1 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.98679374588094 1 0.39506357984191 0.170212765957447 1.1 1 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0973321964852447 0.0419354838709677 1.1 1 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 4.31097025682169e-05 0.000754438780074588 5.99701670644391 0.75 1.3 1 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 4.58179586586031e-05 0.000754438780074588 5.08837781152817 0.636363636363636 1.3 1 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.000709255020706258 0.00731354995989134 4.9975139220366 0.625 1.3 1 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 3.73853154850555e-05 0.000673408910572582 4.56915558586203 0.571428571428571 1.3 1 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 7.22770464313085e-05 0.00108263407443949 4.26454521347123 0.533333333333333 1.3 1 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 6.89317208092235e-06 0.000185075167380236 3.99801113762928 0.5 1.3 1 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000956811949869186 0.00921620145462382 3.99801113762928 0.5 1.3 1 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00263392253406075 0.0180195757979252 3.99801113762928 0.5 1.3 1 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00035172606904176 0.00403634029230987 3.99801113762928 0.5 1.3 1 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 8.33951048410747e-05 0.00121350476952339 3.78758949880668 0.473684210526316 1.3 1 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00022236297140785 0.00273780431363432 3.76283401188638 0.470588235294118 1.3 1 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.00022236297140785 0.00273780431363432 3.76283401188638 0.470588235294118 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00438878675177137 0.0260218481157111 3.63455557966298 0.454545454545455 1.3 1 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.00438878675177137 0.0260218481157111 3.63455557966298 0.454545454545455 1.3 1 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00036129088790131 0.00411293546786852 3.55378767789269 0.444444444444444 1.3 1 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.000958536764078936 0.00921620145462382 3.49825974542562 0.4375 1.3 1 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.000958536764078936 0.00921620145462382 3.49825974542562 0.4375 1.3 1 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.34905238824618e-09 2.08918846779645e-07 3.46997193077258 0.433962264150943 1.3 1 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000215606336588668 0.00273780431363432 3.42686668939652 0.428571428571429 1.3 1 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00255401074689843 0.0179032378957461 3.42686668939652 0.428571428571429 1.3 1 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00255401074689843 0.0179032378957461 3.42686668939652 0.428571428571429 1.3 1 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.00255401074689843 0.0179032378957461 3.42686668939652 0.428571428571429 1.3 1 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 8.06549766849428e-12 1.91286719704456e-09 3.39557110319199 0.424657534246575 1.3 1 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 4.9407841663115e-05 0.000781192874295697 3.38293250107093 0.423076923076923 1.3 1 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00684019732455864 0.0375814702426523 3.3316759480244 0.416666666666667 1.3 1 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0038591886022801 0.0238766320914982 3.19840891010342 0.4 1.3 1 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0038591886022801 0.0238766320914982 3.19840891010342 0.4 1.3 1 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0038591886022801 0.0238766320914982 3.19840891010342 0.4 1.3 1 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000847882277323478 0.0084800708242849 3.19840891010342 0.4 1.3 1 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00218185593870613 0.0158407193917287 3.1095642181561 0.388888888888889 1.3 1 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.000280163791827495 0.00335019391403803 3.07539318279175 0.384615384615385 1.3 1 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.010108961617165 0.0506515928916402 3.07539318279175 0.384615384615385 1.3 1 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00123697516392952 0.0115046775050438 3.04610372390802 0.380952380952381 1.3 1 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00123697516392952 0.0115046775050438 3.04610372390802 0.380952380952381 1.3 1 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 1.25806214330916e-05 0.000288745553214343 2.99850835322196 0.375 1.3 1 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0055995797052008 0.032129846453632 2.99850835322196 0.375 1.3 1 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.00312595703765005 0.0208837411482442 2.94590294351631 0.368421052631579 1.3 1 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.000229009495745506 0.00278530352517825 2.93187483426147 0.366666666666667 1.3 1 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00175583453930806 0.0149394814666792 2.90764446373038 0.363636363636364 1.3 1 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 3.96067799853997e-08 1.94346372135254e-06 2.89710952002121 0.36231884057971 1.3 1 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 2.48573920531026e-05 0.000478000930967095 2.85572224116377 0.357142857142857 1.3 1 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000561775456805591 0.00605610965935118 2.85572224116377 0.357142857142857 1.3 1 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0143061565450909 0.0633849646485175 2.85572224116377 0.357142857142857 1.3 1 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0143061565450909 0.0633849646485175 2.85572224116377 0.357142857142857 1.3 1 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00784997313406559 0.0410680579771152 2.82212550891478 0.352941176470588 1.3 1 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0043526126778259 0.0260218481157111 2.79860779634049 0.35 1.3 1 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0043526126778259 0.0260218481157111 2.79860779634049 0.35 1.3 1 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0043526126778259 0.0260218481157111 2.79860779634049 0.35 1.3 1 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 1.96994613239558e-05 0.000400461906628417 2.78122513922037 0.347826086956522 1.3 1 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00243236072206965 0.0173932126005282 2.78122513922037 0.347826086956522 1.3 1 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00136755348912616 0.0123166368039654 2.76785386451258 0.346153846153846 1.3 1 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.00136755348912616 0.0123166368039654 2.76785386451258 0.346153846153846 1.3 1 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00136755348912616 0.0123166368039654 2.76785386451258 0.346153846153846 1.3 1 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.11767598591776e-06 0.000142793194665901 2.71293612910558 0.339285714285714 1.3 1 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000336496581226238 0.00389296451288566 2.66534075841952 0.333333333333333 1.3 1 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00104443278370973 0.00990818567479298 2.66534075841952 0.333333333333333 1.3 1 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.00329691921630579 0.021466414846721 2.66534075841952 0.333333333333333 1.3 1 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0106840317317454 0.0526068413642687 2.66534075841952 0.333333333333333 1.3 1 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0195296405164963 0.0814975907770505 2.66534075841952 0.333333333333333 1.3 1 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0195296405164963 0.0814975907770505 2.66534075841952 0.333333333333333 1.3 1 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0195296405164963 0.0814975907770505 2.66534075841952 0.333333333333333 1.3 1 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 2.29305601763258e-06 6.94259300657695e-05 2.66534075841952 0.333333333333333 1.3 1 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.000787699322473326 0.0079496179849613 2.58694838317188 0.323529411764706 1.3 1 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.000787699322473326 0.0079496179849613 2.58694838317188 0.323529411764706 1.3 1 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0043819873825023 0.0260218481157111 2.55872712808274 0.32 1.3 1 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.0043819873825023 0.0260218481157111 2.55872712808274 0.32 1.3 1 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0043819873825023 0.0260218481157111 2.55872712808274 0.32 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000336372479941795 0.00389296451288566 2.53532413605759 0.317073170731707 1.3 1 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000336372479941795 0.00389296451288566 2.53532413605759 0.317073170731707 1.3 1 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.58982224636117e-05 0.000327872037184341 2.53207372049854 0.316666666666667 1.3 1 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000589090432266955 0.0062557886948946 2.52505966587112 0.315789473684211 1.3 1 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0141723738982509 0.0633849646485175 2.52505966587112 0.315789473684211 1.3 1 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0141723738982509 0.0633849646485175 2.52505966587112 0.315789473684211 1.3 1 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.00103442079043064 0.00987906566968322 2.51303557222412 0.314285714285714 1.3 1 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.000144176313777357 0.00197272013947288 2.4987569610183 0.3125 1.3 1 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.0018220971814008 0.0149394814666792 2.4987569610183 0.3125 1.3 1 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0258614863398124 0.101101360059212 2.4987569610183 0.3125 1.3 1 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00572173577955835 0.0326989157201267 2.4603145462334 0.307692307692308 1.3 1 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 9.90554636331709e-07 3.21389079470957e-05 2.44584210772615 0.305882352941176 1.3 1 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00134150744248058 0.0123166368039654 2.44322902855122 0.305555555555556 1.3 1 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 6.17561761490685e-08 2.77884371921918e-06 2.39880668257757 0.3 1.3 1 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.73364760953169e-06 0.000107465528641477 2.39880668257757 0.3 1.3 1 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0183808429927187 0.0778335601852755 2.39880668257757 0.3 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0017195271629927 0.0149394814666792 2.37719581156335 0.297297297297297 1.3 1 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0017195271629927 0.0149394814666792 2.37719581156335 0.297297297297297 1.3 1 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0017195271629927 0.0149394814666792 2.37719581156335 0.297297297297297 1.3 1 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00735155754606126 0.0390071429635827 2.36919178526179 0.296296296296296 1.3 1 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00735155754606126 0.0390071429635827 2.36919178526179 0.296296296296296 1.3 1 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.00735155754606126 0.0390071429635827 2.36919178526179 0.296296296296296 1.3 1 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0333662835088736 0.123311849989838 2.35177125742899 0.294117647058824 1.3 1 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0333662835088736 0.123311849989838 2.35177125742899 0.294117647058824 1.3 1 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0333662835088736 0.123311849989838 2.35177125742899 0.294117647058824 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.0130694513188728 0.0592287554992228 2.33217316361708 0.291666666666667 1.3 1 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.0130694513188728 0.0592287554992228 2.33217316361708 0.291666666666667 1.3 1 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0130694513188728 0.0592287554992228 2.33217316361708 0.291666666666667 1.3 1 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000223180112706663 0.00273780431363432 2.32611557098431 0.290909090909091 1.3 1 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.000384449412869256 0.00434183741676945 2.30654488709381 0.288461538461538 1.3 1 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00930756003303439 0.0478146495559853 2.28457779293101 0.285714285714286 1.3 1 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 8.73768914338395e-05 0.00125593249000357 2.26752870492407 0.283582089552239 1.3 1 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.000149149366965249 0.00200225989803349 2.24888126491647 0.28125 1.3 1 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.26857648681668e-07 8.96717872427817e-06 2.24681617651893 0.28099173553719 1.3 1 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.26857648681668e-07 8.96717872427817e-06 2.24681617651893 0.28099173553719 1.3 1 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.66553848535234e-05 0.000754438780074588 2.23888623707239 0.28 1.3 1 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0164479095163502 0.0711409581816604 2.23888623707239 0.28 1.3 1 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 3.40807261040854e-05 0.000621754785206583 2.22674038045175 0.278481012658228 1.3 1 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 3.40807261040854e-05 0.000621754785206583 2.22674038045175 0.278481012658228 1.3 1 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.92545682304225e-05 0.0011747838603322 2.22111729868293 0.277777777777778 1.3 1 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000599093884040762 0.00626846027198533 2.22111729868293 0.277777777777778 1.3 1 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0420902265000767 0.143976904590407 2.22111729868293 0.277777777777778 1.3 1 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.00142041741844087 0.0127122892229016 2.21166573570981 0.276595744680851 1.3 1 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.29055139698589e-10 3.62161626434547e-08 2.20723531556616 0.276041666666667 1.3 1 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.0116260331248431 0.0557031822782888 2.20579924834719 0.275862068965517 1.3 1 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.0116260331248431 0.0557031822782888 2.20579924834719 0.275862068965517 1.3 1 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 4.27724718134363e-07 1.521630684763e-05 2.19245772063541 0.274193548387097 1.3 1 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 4.27724718134363e-07 1.521630684763e-05 2.19245772063541 0.274193548387097 1.3 1 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 4.27724718134363e-07 1.521630684763e-05 2.19245772063541 0.274193548387097 1.3 1 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0291889192271109 0.111058374492457 2.18073334779779 0.272727272727273 1.3 1 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 5.17953992874549e-05 0.000801139708544003 2.17175913648998 0.271604938271605 1.3 1 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 5.17953992874549e-05 0.000801139708544003 2.17175913648998 0.271604938271605 1.3 1 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 3.77601998037517e-06 0.000107465528641477 2.1671462241355 0.271028037383178 1.3 1 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0203996577351682 0.0846318162015869 2.15277522795423 0.269230769230769 1.3 1 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.0203996577351682 0.0846318162015869 2.15277522795423 0.269230769230769 1.3 1 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0143429083744362 0.0633849646485175 2.13227260673561 0.266666666666667 1.3 1 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0143429083744362 0.0633849646485175 2.13227260673561 0.266666666666667 1.3 1 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 3.03733181734609e-10 4.32212317608349e-08 2.13227260673561 0.266666666666667 1.3 1 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00299477605612184 0.0201955665780477 2.13227260673561 0.266666666666667 1.3 1 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 3.06056410831189e-07 1.17707641246698e-05 2.12843758406163 0.266187050359712 1.3 1 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.000106564990135165 0.00150140575210238 2.12552490861303 0.265822784810127 1.3 1 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 2.96112945843836e-05 0.000554432528862867 2.10421638822593 0.263157894736842 1.3 1 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 2.96112945843836e-05 0.000554432528862867 2.10421638822593 0.263157894736842 1.3 1 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.00718662923278254 0.0390071429635827 2.10421638822593 0.263157894736842 1.3 1 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.052060888143586 0.166852801415142 2.10421638822593 0.263157894736842 1.3 1 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.052060888143586 0.166852801415142 2.10421638822593 0.263157894736842 1.3 1 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 2.15222227299083e-05 0.000426244567474476 2.0999654460275 0.262626262626263 1.3 1 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 1.40429693128108e-06 4.44069896269551e-05 2.09126736429839 0.261538461538462 1.3 1 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.000574728012264459 0.0061491576049047 2.09126736429839 0.261538461538462 1.3 1 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00364857993658034 0.0231782555792582 2.08591885441527 0.260869565217391 1.3 1 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.0358841391464592 0.12670751862385 2.08591885441527 0.260869565217391 1.3 1 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0358841391464592 0.12670751862385 2.08591885441527 0.260869565217391 1.3 1 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0249664928013556 0.0997958406076659 2.07304281210407 0.259259259259259 1.3 1 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.000113467770689412 0.00156761784166051 2.06955870653751 0.258823529411765 1.3 1 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.0123245066079628 0.057331199096088 2.05612001363791 0.257142857142857 1.3 1 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.0123245066079628 0.057331199096088 2.05612001363791 0.257142857142857 1.3 1 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.20733041980233e-09 1.14535412491915e-07 2.04382632147864 0.255605381165919 1.3 1 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 1.20733041980233e-09 1.14535412491915e-07 2.04382632147864 0.255605381165919 1.3 1 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9.89360934253168e-05 0.00140786060944226 2.0434279147883 0.255555555555556 1.3 1 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.004412521371371 0.0260540162301284 2.04153760219367 0.25531914893617 1.3 1 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00315145072710984 0.0209556746947537 2.03820175643845 0.254901960784314 1.3 1 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.62978931567669e-06 0.000197403458112871 2.03177615190996 0.254098360655738 1.3 1 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 3.32785739953043e-11 5.91942634941474e-09 2.0284027095325 0.253676470588235 1.3 1 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 2.37864064931495e-05 0.000463672006023997 2.01701462799315 0.252252252252252 1.3 1 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 2.5555482774236e-06 7.57613583077872e-05 2.01338690384208 0.251798561151079 1.3 1 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 6.23395454945094e-17 4.43545866193434e-14 2.00796971934744 0.251121076233184 1.3 1 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.00378167561449814 0.0238034930935932 1.99900556881464 0.25 1.3 1 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00529922116625988 0.0306536248763732 1.99900556881464 0.25 1.3 1 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.00744576622542329 0.0392419456991753 1.99900556881464 0.25 1.3 1 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.0148501405326871 0.0650207691631193 1.99900556881464 0.25 1.3 1 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0148501405326871 0.0650207691631193 1.99900556881464 0.25 1.3 1 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.043489035088988 0.147344992694357 1.99900556881464 0.25 1.3 1 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.043489035088988 0.147344992694357 1.99900556881464 0.25 1.3 1 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.043489035088988 0.147344992694357 1.99900556881464 0.25 1.3 1 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.0632875698605418 0.192146684123328 1.99900556881464 0.25 1.3 1 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0301861370574627 0.113337395864827 1.99900556881464 0.25 1.3 1 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0301861370574627 0.113337395864827 1.99900556881464 0.25 1.3 1 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.0301861370574627 0.113337395864827 1.99900556881464 0.25 1.3 1 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.00632189161355739 0.0355575168620244 1.95820953679801 0.244897959183673 1.3 1 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.00888579245666788 0.0459799369666851 1.95458322284098 0.244444444444444 1.3 1 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.00888579245666788 0.0459799369666851 1.95458322284098 0.244444444444444 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0125298685304873 0.057331199096088 1.95024933542892 0.24390243902439 1.3 1 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 1.69097055278362e-06 5.23098064480673e-05 1.94903042959427 0.24375 1.3 1 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 5.33306771321673e-08 2.52965178530247e-06 1.94189112399136 0.242857142857143 1.3 1 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0252267434965261 0.100553658250859 1.93842964248692 0.242424242424242 1.3 1 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.0027402582656807 0.0186573565170509 1.93452151820771 0.241935483870968 1.3 1 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0360916246723871 0.126800437819809 1.93007434230379 0.241379310344828 1.3 1 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000625743511765965 0.00649951107476619 1.92675235548399 0.240963855421687 1.3 1 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.0053471837074011 0.0308058397393999 1.92496832552521 0.240740740740741 1.3 1 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 5.69221929331236e-07 1.92857810818654e-05 1.92254087492555 0.240437158469945 1.3 1 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.000146352883794239 0.00198343003465906 1.92212073924484 0.240384615384615 1.3 1 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00749426560178791 0.0393518079385395 1.91904534606205 0.24 1.3 1 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0520283379014 0.166852801415142 1.91904534606205 0.24 1.3 1 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0520283379014 0.166852801415142 1.91904534606205 0.24 1.3 1 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0105317735344097 0.0520372004842535 1.912092283214 0.239130434782609 1.3 1 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0105317735344097 0.0520372004842535 1.912092283214 0.239130434782609 1.3 1 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0757621205619935 0.216484934858869 1.90381482744251 0.238095238095238 1.3 1 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0757621205619935 0.216484934858869 1.90381482744251 0.238095238095238 1.3 1 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 6.08251231961485e-06 0.000166450289054076 1.89649246272158 0.237179487179487 1.3 1 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 8.34399232046092e-06 0.000212026804857427 1.89379474940334 0.236842105263158 1.3 1 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.000452137978181565 0.00494917186886436 1.89153215113643 0.236559139784946 1.3 1 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.01685387135335e-07 4.38479714829038e-06 1.88996890142475 0.236363636363636 1.3 1 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 4.78012565813091e-05 0.000764283012530369 1.88882415950989 0.236220472440945 1.3 1 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.00196323473947225 0.0149394814666792 1.88794970388049 0.236111111111111 1.3 1 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.4385420855961e-16 6.82348462601084e-14 1.88670188517337 0.235955056179775 1.3 1 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 6.57185070408526e-05 0.000994866335309928 1.88524102424795 0.235772357723577 1.3 1 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 2.15668368644851e-05 0.000426244567474476 1.88477667916809 0.235714285714286 1.3 1 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 7.11406639885159e-06 0.000187468823806774 1.88441289289533 0.235668789808917 1.3 1 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0298710129518715 0.113049072953492 1.88141700594319 0.235294117647059 1.3 1 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0298710129518715 0.113049072953492 1.88141700594319 0.235294117647059 1.3 1 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.00086409716761863 0.0084800708242849 1.88141700594319 0.235294117647059 1.3 1 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.00086409716761863 0.0084800708242849 1.88141700594319 0.235294117647059 1.3 1 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.00086409716761863 0.0084800708242849 1.88141700594319 0.235294117647059 1.3 1 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0037971840704467 0.0238034930935932 1.87406772076372 0.234375 1.3 1 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0427107991978505 0.145749321962929 1.86573853089366 0.233333333333333 1.3 1 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.00229862534648149 0.0166037759799145 1.8620873791698 0.232876712328767 1.3 1 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 9.67576310961681e-06 0.000233366286525165 1.86070958606646 0.232704402515723 1.3 1 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.5545845301736e-11 3.16024826633863e-09 1.86003726723929 0.232620320855615 1.3 1 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.000447603403357582 0.00493751661223131 1.85766174071663 0.232323232323232 1.3 1 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 1.12523193553209e-05 0.000266097279191517 1.84908015115354 0.23125 1.3 1 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0103451685478461 0.0516007047367245 1.84523590967505 0.230769230769231 1.3 1 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0615169419512695 0.189068268675284 1.84523590967505 0.230769230769231 1.3 1 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0246980319934937 0.0997958406076659 1.84523590967505 0.230769230769231 1.3 1 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 0.000520991227289994 0.00565931691934093 1.83908512330947 0.23 1.3 1 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000319333447842947 0.00378676246900428 1.8339500631327 0.229357798165138 1.3 1 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0145130467174966 0.0639382832167112 1.83242177141342 0.229166666666667 1.3 1 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 5.42474564009839e-05 0.000830044413533334 1.82766223434481 0.228571428571429 1.3 1 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000439323179692566 0.00488403816173844 1.82766223434481 0.228571428571429 1.3 1 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00371885230688279 0.0235196748119742 1.82766223434481 0.228571428571429 1.3 1 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.0350699777945111 0.124761446003973 1.82766223434481 0.228571428571429 1.3 1 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0350699777945111 0.124761446003973 1.82766223434481 0.228571428571429 1.3 1 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.000269410019165261 0.0032489021802726 1.82365420312914 0.228070175438596 1.3 1 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00136606572402261 0.0123166368039654 1.81727778983149 0.227272727272727 1.3 1 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0894601209546059 0.247153744722039 1.81727778983149 0.227272727272727 1.3 1 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00718528070033657 0.0390071429635827 1.80555341699387 0.225806451612903 1.3 1 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0500659257856024 0.161917755438437 1.80555341699387 0.225806451612903 1.3 1 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0500659257856024 0.161917755438437 1.80555341699387 0.225806451612903 1.3 1 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0288214407002562 0.109954182617868 1.79910501193317 0.225 1.3 1 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000161228882022803 0.00212433980665231 1.79755539521316 0.224806201550388 1.3 1 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.0015809241710734 0.014060344346484 1.79685893826035 0.224719101123595 1.3 1 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.0168841705633738 0.0728065900353968 1.79502540873151 0.224489795918367 1.3 1 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.0100098193194895 0.0506515928916402 1.79221188928209 0.224137931034483 1.3 1 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.0100098193194895 0.0506515928916402 1.79221188928209 0.224137931034483 1.3 1 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.90887081354827e-06 0.000222409178380337 1.79145854254427 0.224043715846995 1.3 1 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 8.35723593909289e-05 0.00121350476952339 1.78931966998793 0.223776223776224 1.3 1 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 0.00360336555971759 0.0230972486102618 1.78858392999204 0.223684210526316 1.3 1 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00218029676611768 0.0158407193917287 1.78734615564603 0.223529411764706 1.3 1 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0719599274226735 0.206449549843678 1.77689383894635 0.222222222222222 1.3 1 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00300875622947724 0.0201955665780477 1.77689383894634 0.222222222222222 1.3 1 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00498684135158314 0.0289643887481747 1.77689383894634 0.222222222222222 1.3 1 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.00182381649954804 0.0149394814666792 1.77689383894634 0.222222222222222 1.3 1 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.00251216212198887 0.0178740334979508 1.76656306081294 0.22093023255814 1.3 1 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000778439273748161 0.0079496179849613 1.76059206060739 0.220183486238532 1.3 1 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0334034453730038 0.123311849989838 1.75522440188602 0.219512195121951 1.3 1 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.04111379875083e-05 0.000718813116952804 1.75060842712761 0.218934911242604 1.3 1 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 4.40642558360694e-07 1.52935209889578e-05 1.74625773827486 0.218390804597701 1.3 1 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.00288533598774356 0.0195515862407576 1.74625773827486 0.218390804597701 1.3 1 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0161079911585793 0.0698831445690803 1.74458667823823 0.218181818181818 1.3 1 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 4.61881442778286e-05 0.000754438780074588 1.74031073049745 0.217647058823529 1.3 1 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00794019908196528 0.041387924152515 1.73826571201273 0.217391304347826 1.3 1 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.00240521244834945 0.0172859460303094 1.73826571201273 0.217391304347826 1.3 1 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0273741342583136 0.104713422176291 1.73826571201273 0.217391304347826 1.3 1 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.104342338123536 0.271939829944673 1.73826571201273 0.217391304347826 1.3 1 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.104342338123536 0.271939829944673 1.73826571201273 0.217391304347826 1.3 1 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0472222949665749 0.158484258814708 1.72886968113698 0.216216216216216 1.3 1 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.0033036857705073 0.021466414846721 1.72641390033991 0.215909090909091 1.3 1 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.0224756797611382 0.091904862931321 1.72463225544792 0.215686274509804 1.3 1 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.0224756797611382 0.091904862931321 1.72463225544792 0.215686274509804 1.3 1 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.0224756797611382 0.091904862931321 1.72463225544792 0.215686274509804 1.3 1 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.0109902998536962 0.0538525122509624 1.72222018236338 0.215384615384615 1.3 1 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 1.14068404994256e-05 0.000266097279191517 1.71343334469826 0.214285714285714 1.3 1 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00909147547516959 0.0468738029027766 1.71343334469826 0.214285714285714 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0833527793404582 0.234247483107184 1.71343334469826 0.214285714285714 1.3 1 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000179187859948579 0.00231803931551662 1.70237893602279 0.212903225806452 1.3 1 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.0314207799960546 0.11766255245891 1.70128133516139 0.212765957446809 1.3 1 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0670436765759927 0.198756566182578 1.69612593717606 0.212121212121212 1.3 1 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.0021697882644368 0.0158407193917287 1.69146625053546 0.211538461538462 1.3 1 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.0103709076280416 0.0516007047367245 1.68930048068843 0.211267605633803 1.3 1 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.00356438641811295 0.022950777705768 1.68337311058075 0.210526315789474 1.3 1 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0542119415507082 0.172967696920757 1.68337311058075 0.210526315789474 1.3 1 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.0542119415507082 0.172967696920757 1.68337311058075 0.210526315789474 1.3 1 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00587679235630998 0.0333174323626658 1.67358605761226 0.209302325581395 1.3 1 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00587679235630998 0.0333174323626658 1.67358605761226 0.209302325581395 1.3 1 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0440215426858809 0.14844231100002 1.67358605761226 0.209302325581395 1.3 1 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0440215426858809 0.14844231100002 1.67358605761226 0.209302325581395 1.3 1 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0142945761659161 0.0633849646485175 1.67081062468089 0.208955223880597 1.3 1 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.000217740117793754 0.00273780431363432 1.66788194698645 0.208588957055215 1.3 1 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 9.93754005391574e-07 3.21389079470957e-05 1.66470088324495 0.208191126279863 1.3 1 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 3.59903482708758e-10 4.6558423263142e-08 1.65771193511458 0.207317073170732 1.3 1 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.17861773956504e-19 4.52317304340105e-16 1.65683344442294 0.207207207207207 1.3 1 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 5.10052900658036e-15 1.45161055527277e-12 1.64834774176265 0.206145966709347 1.3 1 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.076681033811876 0.21693262646978 1.64623988020029 0.205882352941176 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.00261424032649568 0.0180195757979252 1.64204028866917 0.205357142857143 1.3 1 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0110127063000914 0.0538525122509624 1.64020969748893 0.205128205128205 1.3 1 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00622319039581754 0.0351412695763824 1.63359594870874 0.204301075268817 1.3 1 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.0407383919332423 0.141737730369202 1.63184128066501 0.204081632653061 1.3 1 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 9.28885183556984e-06 0.00022789717520717 1.62995838687963 0.203846153846154 1.3 1 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.00354571956823003 0.022934358843597 1.62881935236748 0.203703703703704 1.3 1 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0271899336958866 0.104289152693387 1.62630961530682 0.203389830508475 1.3 1 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0271899336958866 0.104289152693387 1.62630961530682 0.203389830508475 1.3 1 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 0.00017019655671563 0.00222192385510405 1.62486014149639 0.203208556149733 1.3 1 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 8.95035398955395e-16 3.18408843178382e-13 1.61910405799919 0.202488687782805 1.3 1 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 8.79414412254656e-10 9.62620545106443e-08 1.61136570566047 0.201520912547529 1.3 1 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0169575997740012 0.0729023096024279 1.59920445505171 0.2 1.3 1 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.108924520463525 0.282808066332552 1.59920445505171 0.2 1.3 1 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.108924520463525 0.282808066332552 1.59920445505171 0.2 1.3 1 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.0700801827495195 0.203104073426815 1.59920445505171 0.2 1.3 1 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.0700801827495195 0.203104073426815 1.59920445505171 0.2 1.3 1 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.137438372072013 0.330362843679855 1.59920445505171 0.2 1.3 1 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.137438372072013 0.330362843679855 1.59920445505171 0.2 1.3 1 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.137438372072013 0.330362843679855 1.59920445505171 0.2 1.3 1 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 6.24898095678241e-08 2.77884371921918e-06 1.59545045398351 0.199530516431925 1.3 1 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.0156590688938201 0.0683523160610612 1.57946119017453 0.197530864197531 1.3 1 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.0190191894301186 0.0800719128966235 1.57816229116945 0.197368421052632 1.3 1 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0344432565989575 0.123457818993241 1.57298798857545 0.19672131147541 1.3 1 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 0.00117965861382977 0.011116915281323 1.5688398135001 0.19620253164557 1.3 1 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.00428400249989001 0.0260218481157111 1.56019946834313 0.195121951219512 1.3 1 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.0175048211031496 0.0750281940656079 1.56019946834313 0.195121951219512 1.3 1 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.0789715130226143 0.222527649566693 1.56019946834313 0.195121951219512 1.3 1 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.0789715130226143 0.222527649566693 1.56019946834313 0.195121951219512 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0982443862861583 0.257145392712726 1.55478210907805 0.194444444444444 1.3 1 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.0982443862861583 0.257145392712726 1.55478210907805 0.194444444444444 1.3 1 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.123050583186226 0.306656707309982 1.54761721456617 0.193548387096774 1.3 1 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0160843960126875 0.0698831445690803 1.54468612135677 0.193181818181818 1.3 1 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0472082270285151 0.158484258814708 1.54309201803235 0.192982456140351 1.3 1 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.155514903053142 0.361007678702481 1.53769659139588 0.192307692307692 1.3 1 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.155514903053142 0.361007678702481 1.53769659139588 0.192307692307692 1.3 1 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.155514903053142 0.361007678702481 1.53769659139588 0.192307692307692 1.3 1 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.0351731383879514 0.124816398818092 1.52865131732884 0.191176470588235 1.3 1 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0885026518210486 0.246456503994818 1.52305186195401 0.19047619047619 1.3 1 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.110149540927394 0.282808066332552 1.51276097099486 0.189189189189189 1.3 1 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.0240512118022309 0.0977853554130703 1.50513360475455 0.188235294117647 1.3 1 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.0240512118022309 0.0977853554130703 1.50513360475455 0.188235294117647 1.3 1 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.000110600007524291 0.00154297853634378 1.50105833326153 0.187725631768953 1.3 1 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.0477472207457514 0.158491190434033 1.49925417661098 0.1875 1.3 1 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.138022236680589 0.331206817532004 1.49925417661098 0.1875 1.3 1 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.00203405569291677 0.0153960704841519 1.49078381403126 0.186440677966102 1.3 1 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00949362834965784 0.0485950832430327 1.48313316395925 0.185483870967742 1.3 1 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.174504670241885 0.395766424969391 1.48074486578862 0.185185185185185 1.3 1 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.174504670241885 0.395766424969391 1.48074486578862 0.185185185185185 1.3 1 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 0.00205069964870465 0.0154399238100884 1.47752585521082 0.184782608695652 1.3 1 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00419668509994898 0.0258523069144043 1.47697226740445 0.184713375796178 1.3 1 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000596639339922302 0.00626846027198533 1.47566076324514 0.184549356223176 1.3 1 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.00660353682434115 0.0369954051221947 1.47444382380654 0.184397163120567 1.3 1 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.153795250037166 0.358771542299816 1.45382223186519 0.181818181818182 1.3 1 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.153795250037166 0.358771542299816 1.45382223186519 0.181818181818182 1.3 1 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0642012503572381 0.192739196747573 1.43212339258362 0.17910447761194 1.3 1 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0642012503572381 0.192739196747573 1.43212339258362 0.17910447761194 1.3 1 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.80622830547233e-07 7.55959670202098e-06 1.43008174440861 0.178849144634526 1.3 1 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.000209375940061739 0.00268416182619688 1.42260519007668 0.177914110429448 1.3 1 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.170319724942586 0.38902884204382 1.41106275445739 0.176470588235294 1.3 1 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.170319724942586 0.38902884204382 1.41106275445739 0.176470588235294 1.3 1 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.150121052827506 0.353094641609159 1.39930389817025 0.175 1.3 1 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0859545864880214 0.240774363331603 1.39613087345784 0.174603174603175 1.3 1 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.0121454196270683 0.057331199096088 1.39285549310955 0.174193548387097 1.3 1 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.132889703318421 0.329446076345145 1.39061256961018 0.173913043478261 1.3 1 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.0256666806709004 0.101101360059212 1.38773940314405 0.173553719008264 1.3 1 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.0417337996051354 0.143976904590407 1.38706508856526 0.173469387755102 1.3 1 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.214869990883785 0.45230768791069 1.37862453021699 0.172413793103448 1.3 1 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.214869990883785 0.45230768791069 1.37862453021699 0.172413793103448 1.3 1 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.214869990883785 0.45230768791069 1.37862453021699 0.172413793103448 1.3 1 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.0546382083080655 0.173937741437085 1.36102506812912 0.170212765957447 1.3 1 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.145484948475002 0.343895484518152 1.36102506812912 0.170212765957447 1.3 1 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.0492144582115907 0.161917755438437 1.35932378679395 0.17 1.3 1 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.0492144582115907 0.161917755438437 1.35932378679395 0.17 1.3 1 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.0036327273850866 0.0231782555792582 1.34834885425929 0.168627450980392 1.3 1 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.0131478079548408 0.0593947006975824 1.33987400288116 0.167567567567568 1.3 1 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.180022854627653 0.399645120335648 1.33267037920976 0.166666666666667 1.3 1 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.20540026423628 0.444617185556286 1.33267037920976 0.166666666666667 1.3 1 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 0.00495265604317903 0.0288837276616548 1.33267037920976 0.166666666666667 1.3 1 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 0.00495265604317903 0.0288837276616548 1.33267037920976 0.166666666666667 1.3 1 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 0.00495265604317903 0.0288837276616548 1.33267037920976 0.166666666666667 1.3 1 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 0.037048868059876 0.129217007963734 1.32265030117059 0.165413533834586 1.3 1 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0602066958400455 0.186248104739967 1.30844000867867 0.163636363636364 1.3 1 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.152321289253669 0.357089282714945 1.30844000867867 0.163636363636364 1.3 1 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.195841511434041 0.431397013576842 1.30167804480953 0.162790697674419 1.3 1 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.9849027460332e-10 4.7254305063377e-08 1.29567565596507 0.162040025823112 1.3 1 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.257791489156608 0.513179774427092 1.28968101213848 0.161290322580645 1.3 1 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.257791489156608 0.513179774427092 1.28968101213848 0.161290322580645 1.3 1 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.186529453835341 0.4128015751286 1.27936356404137 0.16 1.3 1 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.139835143011948 0.334722339630064 1.27472818880933 0.159420289855072 1.3 1 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.212183007897923 0.448642526357718 1.27209445288204 0.159090909090909 1.3 1 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.133838587198682 0.330362843679855 1.26252983293556 0.157894736842105 1.3 1 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 0.000426424808693583 0.00477797246276354 1.26031874741378 0.157618213660245 1.3 1 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.0689506385367233 0.200774951444099 1.25921610633993 0.15748031496063 1.3 1 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.128057659269572 0.318021028168589 1.25238903106459 0.156626506024096 1.3 1 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 0.0346870943213046 0.124019435224162 1.24937848050915 0.15625 1.3 1 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.279970980355871 0.542777527311178 1.24937848050915 0.15625 1.3 1 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.229002574114816 0.468204975524975 1.24382568726244 0.155555555555556 1.3 1 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.262178270936687 0.513179774427092 1.2301572731167 0.153846153846154 1.3 1 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.262178270936687 0.513179774427092 1.2301572731167 0.153846153846154 1.3 1 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.1462036102227 0.344449896269706 1.22292105386307 0.152941176470588 1.3 1 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.1462036102227 0.344449896269706 1.22292105386307 0.152941176470588 1.3 1 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.172214310660481 0.392725903958115 1.22161451427561 0.152777777777778 1.3 1 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.0638466596463755 0.192486857366085 1.21890583464307 0.152439024390244 1.3 1 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.246253602206476 0.499884273808581 1.21678599840891 0.152173913043478 1.3 1 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.0939853279531013 0.253297578934211 1.21151852655433 0.151515151515152 1.3 1 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.193800736705154 0.428227404241356 1.21151852655433 0.151515151515152 1.3 1 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.302502360769925 0.550763135912548 1.21151852655433 0.151515151515152 1.3 1 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.231857193119808 0.472683074225626 1.20694675852959 0.150943396226415 1.3 1 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.231857193119808 0.472683074225626 1.20694675852959 0.150943396226415 1.3 1 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0952707368082372 0.25627648105505 1.19940334128878 0.15 1.3 1 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.218739385980492 0.454396376696695 1.19940334128878 0.15 1.3 1 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.218739385980492 0.454396376696695 1.19940334128878 0.15 1.3 1 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.281953074132424 0.54513481588375 1.19940334128878 0.15 1.3 1 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.0834599254640494 0.234247483107184 1.19195363109444 0.149068322981366 1.3 1 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0921178153892864 0.250637956594559 1.1865065311674 0.148387096774194 1.3 1 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.247764162551546 0.500083017923529 1.1845958926309 0.148148148148148 1.3 1 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.08810777412969 0.245837965855978 1.1845958926309 0.148148148148148 1.3 1 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0707776021745586 0.204708390029262 1.17707942123095 0.147208121827411 1.3 1 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.325292470395329 0.577891617194198 1.17588562871449 0.147058823529412 1.3 1 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.30204168898486 0.550763135912548 1.17014960125735 0.146341463414634 1.3 1 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.30204168898486 0.550763135912548 1.17014960125735 0.146341463414634 1.3 1 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.124212903965032 0.309012171926993 1.16730252193556 0.145985401459854 1.3 1 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.281857227398541 0.54513481588375 1.16608658180854 0.145833333333333 1.3 1 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.159418185387229 0.369310733821402 1.16305778549215 0.145454545454545 1.3 1 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.233549762498629 0.474773302907927 1.15884380800849 0.144927536231884 1.3 1 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.233549762498629 0.474773302907927 1.15884380800849 0.144927536231884 1.3 1 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.113544668929358 0.28597179448934 1.15665731025753 0.144654088050314 1.3 1 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.113544668929358 0.28597179448934 1.15665731025753 0.144654088050314 1.3 1 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.300111562168376 0.550763135912548 1.14228889646551 0.142857142857143 1.3 1 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.300111562168376 0.550763135912548 1.14228889646551 0.142857142857143 1.3 1 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.322378161377728 0.574991625425428 1.14228889646551 0.142857142857143 1.3 1 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.247433717398605 0.500083017923529 1.14228889646551 0.142857142857143 1.3 1 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.247433717398605 0.500083017923529 1.14228889646551 0.142857142857143 1.3 1 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.263130979181409 0.513179774427092 1.14228889646551 0.142857142857143 1.3 1 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.348251056920452 0.608304615086995 1.14228889646551 0.142857142857143 1.3 1 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.0211023884999409 0.0872927291727208 1.13075062478404 0.141414141414141 1.3 1 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.159610752846214 0.369310733821402 1.12620032045895 0.140845070422535 1.3 1 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.144334517028041 0.341743789901668 1.12139336787163 0.140243902439024 1.3 1 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.206796944127528 0.444617185556286 1.12093770213905 0.14018691588785 1.3 1 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.318601672827242 0.569560528182368 1.1194431185362 0.14 1.3 1 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.175954925838889 0.395766424969391 1.11709134727877 0.139705882352941 1.3 1 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.143899163489026 0.34128084940814 1.11572403840817 0.13953488372093 1.3 1 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.342897618125353 0.604405115585814 1.11572403840817 0.13953488372093 1.3 1 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.195107333728707 0.430446102164264 1.11419982524095 0.139344262295082 1.3 1 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.371291507353383 0.626281193891063 1.11055864934147 0.138888888888889 1.3 1 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.184286268344002 0.408472523136316 1.10893739583878 0.138686131386861 1.3 1 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.257340268864745 0.513179774427092 1.10289962417359 0.137931034482759 1.3 1 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.257340268864745 0.513179774427092 1.10289962417359 0.137931034482759 1.3 1 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.363536767108631 0.626281193891063 1.09036667389889 0.136363636363636 1.3 1 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.363536767108631 0.626281193891063 1.09036667389889 0.136363636363636 1.3 1 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.28701169688097 0.550763135912548 1.08587956824499 0.135802469135802 1.3 1 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.28701169688097 0.550763135912548 1.08587956824499 0.135802469135802 1.3 1 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.331617855962145 0.586930608251409 1.08420641020455 0.135593220338983 1.3 1 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.305506887391624 0.550763135912548 1.08054355071062 0.135135135135135 1.3 1 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.305506887391624 0.550763135912548 1.08054355071062 0.135135135135135 1.3 1 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.196457416577084 0.432084859025024 1.07921773040299 0.134969325153374 1.3 1 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 0.151452494278466 0.355638447785903 1.06613630336781 0.133333333333333 1.3 1 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.384234335261527 0.631297237843841 1.06613630336781 0.133333333333333 1.3 1 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.335712008292062 0.593438742608204 1.05210819411297 0.131578947368421 1.3 1 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.41729321989823 0.670082310662706 1.05210819411297 0.131578947368421 1.3 1 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.304911911710817 0.550763135912548 1.04998272301375 0.131313131313131 1.3 1 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.366458718977974 0.626281193891063 1.0486586590503 0.131147540983607 1.3 1 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.299993155510943 0.550763135912548 1.04620852199645 0.130841121495327 1.3 1 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.404931445219784 0.651829690664878 1.04295942720764 0.130434782608696 1.3 1 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.317834129179368 0.568903101663196 1.03948289578361 0.13 1.3 1 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.286051981633263 0.550763135912548 1.03765174564424 0.129770992366412 1.3 1 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.286051981633263 0.550763135912548 1.03765174564424 0.129770992366412 1.3 1 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.440104241804339 0.690004354518057 1.02513106093058 0.128205128205128 1.3 1 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.440104241804339 0.690004354518057 1.02513106093058 0.128205128205128 1.3 1 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.412898043530453 0.663902729880039 1.01767556230563 0.127272727272727 1.3 1 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 0.401587039782239 0.647178207938987 1.01536790796934 0.126984126984127 1.3 1 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.0119325292921564 0.0569798294722771 1.01412965442304 0.126829268292683 1.3 1 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.381898843153153 0.631297237843841 1.01215471838716 0.126582278481013 1.3 1 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.381898843153153 0.631297237843841 1.01215471838716 0.126582278481013 1.3 1 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.343189974275009 0.604405115585814 1.00790196746957 0.126050420168067 1.3 1 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.336641610042424 0.59434368621634 1.00737288507194 0.125984251968504 1.3 1 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.419168372339136 0.670952299031036 0.999502784407319 0.125 1.3 1 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.44610260446705 0.690004354518057 0.999502784407319 0.125 1.3 1 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.44610260446705 0.690004354518057 0.999502784407319 0.125 1.3 1 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.4318040040409 0.683103689622616 0.999502784407319 0.125 1.3 1 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.466473447578493 0.711633562448994 0.979104768399006 0.122448979591837 1.3 1 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.428528486659859 0.683103689622616 0.975124667714458 0.121951219512195 1.3 1 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.469323123921897 0.711633562448994 0.965037171151894 0.120689655172414 1.3 1 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.471573377491916 0.711633562448994 0.954748928389081 0.119402985074627 1.3 1 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.459535237151766 0.705413853793919 0.951907413721256 0.119047619047619 1.3 1 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.459535237151766 0.705413853793919 0.951907413721256 0.119047619047619 1.3 1 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.506987888813477 0.743620640116748 0.951907413721256 0.119047619047619 1.3 1 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.487860371531864 0.731533518113637 0.948680608928981 0.11864406779661 1.3 1 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.526177458551382 0.766377199097867 0.922617954837525 0.115384615384615 1.3 1 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.526177458551382 0.766377199097867 0.922617954837525 0.115384615384615 1.3 1 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.524317506424906 0.765234678607837 0.917576326669014 0.114754098360656 1.3 1 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.545476863353721 0.783262943039702 0.905210068897195 0.113207547169811 1.3 1 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.564417893101329 0.798376403462416 0.888446919473173 0.111111111111111 1.3 1 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.555987516341494 0.795380765679832 0.888446919473172 0.111111111111111 1.3 1 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.555987516341494 0.795380765679832 0.888446919473172 0.111111111111111 1.3 1 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.572198813978956 0.808578860270164 0.876276413726965 0.10958904109589 1.3 1 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.582971344069191 0.815701300501926 0.872293339119115 0.109090909090909 1.3 1 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.6210181282486 0.850537821460787 0.841686555290374 0.105263157894737 1.3 1 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.629342827845499 0.86028323153136 0.832918987006099 0.104166666666667 1.3 1 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.629342827845499 0.86028323153136 0.832918987006099 0.104166666666667 1.3 1 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.636064804548489 0.868637444215451 0.827174718130195 0.103448275862069 1.3 1 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.657991975253638 0.885830256183469 0.81119066560594 0.101449275362319 1.3 1 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.734952700065275 0.942196119092691 0.802813481451662 0.100401606425703 1.3 1 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.665763259907598 0.894599734512287 0.799602227525855 0.1 1.3 1 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.687610992753699 0.912136514664718 0.788340224321266 0.0985915492957746 1.3 1 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.687610992753699 0.912136514664718 0.788340224321266 0.0985915492957746 1.3 1 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.700229995588031 0.919213361366945 0.773808607283086 0.0967741935483871 1.3 1 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.715830452992919 0.932189388138918 0.754341724080996 0.0943396226415094 1.3 1 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.788858547492133 0.991648156432249 0.708508302871011 0.0886075949367089 1.3 1 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.788858547492133 0.991648156432249 0.708508302871011 0.0886075949367089 1.3 1 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.90341169992814 1 0.61507863655835 0.0769230769230769 1.3 1 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.959590587552631 1 0.601851138997956 0.0752688172043011 1.3 1 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.962937228872399 1 0.518260703026017 0.0648148148148148 1.3 1 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.999999999982407 1 0.456531918318708 0.0570948782535684 1.3 1 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.995635446499509 1 0.454319447457872 0.0568181818181818 1.3 1 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.99993401801823 1 0.453382706329093 0.0567010309278351 1.3 1 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.977090036044911 1 0.444223459736586 0.0555555555555556 1.3 1 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.986822825196971 1 0.412166096662812 0.0515463917525773 1.3 1 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999898052145136 1 0.399801113762928 0.05 1.3 1 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.999999999999999 1 0.361483827995414 0.0452079566003617 1.3 1 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999998939740967 1 0.221088173509453 0.0276497695852535 1.3 1 3 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.0021012421251205 0.00882025824202498 2.43117224638414 1 10.1 10 1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%REACT_206751.1 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS 0.0021012421251205 0.00882025824202498 2.43117224638414 1 10.1 10 1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.000178339921825633 0.00114831542424378 2.43117224638414 1 10.1 10 1 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.000178339921825633 0.00114831542424378 2.43117224638414 1 10.1 10 1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 3.5531775402813e-06 3.89292156152455e-05 2.24415899666228 0.923076923076923 10.1 10 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000346496696175257 0.00202907324550366 2.1610419967859 0.888888888888889 10.1 10 1 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.000346496696175257 0.00202907324550366 2.1610419967859 0.888888888888889 10.1 10 1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%REACT_199093.2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES) 0.00106306725344279 0.00519468422219683 2.12727571558612 0.875 10.1 10 1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 CHL1 INTERACTIONS%REACTOME%REACT_198267.2 CHL1 INTERACTIONS 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00321520834672789 0.0124327214059614 2.08386192547212 0.857142857142857 10.1 10 1 METHIONINE SALVAGE PATHWAY%REACTOME%REACT_199099.2 METHIONINE SALVAGE PATHWAY 0.00954656140952179 0.0276112944832307 2.02597687198678 0.833333333333333 10.1 10 1 INTERLEUKIN-1 PROCESSING%REACTOME%REACT_198700.2 INTERLEUKIN-1 PROCESSING 0.00954656140952179 0.0276112944832307 2.02597687198678 0.833333333333333 10.1 10 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 2.37257905885447e-05 0.00020712760740797 1.97532745018711 0.8125 10.1 10 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 7.27668215910059e-08 1.11341061423657e-06 1.9636391220795 0.807692307692308 10.1 10 1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.0012858665023411 0.00603510549505522 1.94493779710731 0.8 10.1 10 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0012858665023411 0.00603510549505522 1.94493779710731 0.8 10.1 10 1 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 6.66519288379468e-05 0.000524009363184521 1.94493779710731 0.8 10.1 10 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 1.36825780319322e-08 2.37442787066336e-07 1.89935331748761 0.78125 10.1 10 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.000502623547910784 0.00275089734106556 1.87013249721857 0.769230769230769 10.1 10 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 9.86911180135653e-08 1.47828906245583e-06 1.86389872222784 0.766666666666667 10.1 10 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 7.37311716446789e-05 0.000573330367488405 1.85913171782317 0.764705882352941 10.1 10 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 1.69258318618375e-06 1.97421792945859e-05 1.84769090725195 0.76 10.1 10 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 4.44945576982961e-06 4.69005597071669e-05 1.82337918478811 0.75 10.1 10 1 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.00134255011091133 0.00615765388959461 1.82337918478811 0.75 10.1 10 1 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.00134255011091133 0.00615765388959461 1.82337918478811 0.75 10.1 10 1 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00134255011091133 0.00615765388959461 1.82337918478811 0.75 10.1 10 1 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00967163162658321 0.0276916132889897 1.82337918478811 0.75 10.1 10 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 1.77839939558681e-06 2.05744905684556e-05 1.80086833065492 0.740740740740741 10.1 10 1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.00350498479087446 0.0130822297572083 1.76812527009756 0.727272727272727 10.1 10 1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.00350498479087446 0.0130822297572083 1.76812527009756 0.727272727272727 10.1 10 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 7.4603177616198e-05 0.000576958270368749 1.7365516045601 0.714285714285714 10.1 10 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.00129778094271743 0.00603510549505522 1.7365516045601 0.714285714285714 10.1 10 1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0253749440665065 0.0635713827581669 1.7365516045601 0.714285714285714 10.1 10 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 2.87980395090204e-05 0.00024538688755291 1.72208034118877 0.708333333333333 10.1 10 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000487508356245695 0.00269931669625535 1.71612158568292 0.705882352941177 10.1 10 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000185039358026386 0.00118076684516389 1.7018205724689 0.7 10.1 10 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000185039358026386 0.00118076684516389 1.7018205724689 0.7 10.1 10 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.0089031921741347 0.0261761207929621 1.7018205724689 0.7 10.1 10 1 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.0089031921741347 0.0261761207929621 1.7018205724689 0.7 10.1 10 1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0089031921741347 0.0261761207929621 1.7018205724689 0.7 10.1 10 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 4.43472281992904e-12 1.75294738132195e-10 1.69125025835418 0.695652173913043 10.1 10 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 2.72424763698514e-05 0.000233530384784931 1.68311924749671 0.692307692307692 10.1 10 1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00323238487766256 0.0124652674279507 1.68311924749671 0.692307692307692 10.1 10 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 1.58081463011138e-08 2.71024002246807e-07 1.6714309193891 0.6875 10.1 10 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.00119824335019407 0.00576047394366944 1.6714309193891 0.6875 10.1 10 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 4.01583472965257e-12 1.75294738132195e-10 1.66518647012612 0.684931506849315 10.1 10 1 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.000171084587154273 0.00111165921242251 1.65761744071646 0.681818181818182 10.1 10 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 5.7650986531379e-07 7.25994281718162e-06 1.6410412663093 0.675 10.1 10 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 2.07159539687813e-11 6.69972784035813e-10 1.6318827407236 0.671232876712329 10.1 10 1 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00782985415080075 0.0237566790119178 1.62078149758943 0.666666666666667 10.1 10 1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%REACT_211817.1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605571 PROSTANOID LIGAND RECEPTORS 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0218727664719912 0.0560809850263848 1.62078149758943 0.666666666666667 10.1 10 1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 2.29229484265774e-05 0.000201354046981603 1.62078149758943 0.666666666666667 10.1 10 1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.00287572401185003 0.0114626198007355 1.62078149758943 0.666666666666667 10.1 10 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 2.90248955640288e-08 4.69345754404693e-07 1.60549110610273 0.660377358490566 10.1 10 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 1.58455314595104e-11 5.36861696830556e-10 1.60026527610095 0.658227848101266 10.1 10 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 1.58455314595104e-11 5.36861696830556e-10 1.60026527610095 0.658227848101266 10.1 10 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000137690372687708 0.00101519896546429 1.58961262263578 0.653846153846154 10.1 10 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 4.2817787367078e-07 5.44015280565643e-06 1.58554711720705 0.652173913043478 10.1 10 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.000943440869192479 0.00472717027063696 1.58026196014969 0.65 10.1 10 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.000943440869192479 0.00472717027063696 1.58026196014969 0.65 10.1 10 1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605572 EICOSANOID LIGAND-BINDING RECEPTORS 0.00671467196056379 0.0216666172332931 1.56289644410409 0.642857142857143 10.1 10 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00671467196056379 0.0216666172332931 1.56289644410409 0.642857142857143 10.1 10 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.00671467196056379 0.0216666172332931 1.56289644410409 0.642857142857143 10.1 10 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.91343001911252e-09 5.52774788959615e-08 1.56030457603758 0.641791044776119 10.1 10 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 4.08600812731919e-10 8.80968115935637e-09 1.55595023768585 0.64 10.1 10 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.000313478481196446 0.0018742852048006 1.55595023768585 0.64 10.1 10 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.000313478481196446 0.0018742852048006 1.55595023768585 0.64 10.1 10 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 4.09861765535121e-05 0.000335191547331309 1.54710961133536 0.636363636363636 10.1 10 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000816859199308617 0.00420793641965867 1.54710961133536 0.636363636363636 10.1 10 1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0183500550948401 0.0483557933332545 1.54710961133536 0.636363636363636 10.1 10 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.0021430208594364 0.00894287003805865 1.53547720824262 0.631578947368421 10.1 10 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0021430208594364 0.00894287003805865 1.53547720824262 0.631578947368421 10.1 10 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 2.7871059088462e-10 6.83802018670369e-09 1.53073808105668 0.62962962962963 10.1 10 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 2.7871059088462e-10 6.83802018670369e-09 1.53073808105668 0.62962962962963 10.1 10 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000270781749454283 0.00167531491075411 1.53073808105668 0.62962962962963 10.1 10 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.51146342749904e-07 8.0572282237662e-06 1.52544140949593 0.627450980392157 10.1 10 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 6.51146342749904e-07 8.0572282237662e-06 1.52544140949593 0.627450980392157 10.1 10 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 1.20911887457102e-05 0.000117847682090039 1.51948265399009 0.625 10.1 10 1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000699802052693214 0.00368821600363868 1.51948265399009 0.625 10.1 10 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.00567152511460996 0.0188125413475291 1.51948265399009 0.625 10.1 10 1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%REACT_223974.1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.0515471314663788 0.109316792960741 1.51948265399009 0.625 10.1 10 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 2.98877628351022e-11 9.24571445964139e-10 1.51621494935785 0.623655913978495 10.1 10 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 2.12334349839201e-10 5.39556749680685e-09 1.51590740068658 0.623529411764706 10.1 10 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 1.31376950560657e-09 2.63309014996921e-08 1.50794227940282 0.620253164556962 10.1 10 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.00181692573850427 0.00781113391508027 1.50501139061875 0.619047619047619 10.1 10 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00181692573850427 0.00781113391508027 1.50501139061875 0.619047619047619 10.1 10 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00181692573850427 0.00781113391508027 1.50501139061875 0.619047619047619 10.1 10 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 3.55642869288961e-06 3.89292156152455e-05 1.50008500308809 0.617021276595745 10.1 10 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 3.55642869288961e-06 3.89292156152455e-05 1.50008500308809 0.617021276595745 10.1 10 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 5.81709630677332e-08 8.99753048319394e-07 1.49610599777486 0.615384615384615 10.1 10 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 6.82795899936387e-12 2.4290464140237e-10 1.49610599777486 0.615384615384615 10.1 10 1 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0151858049878219 0.0408495283509839 1.49610599777486 0.615384615384615 10.1 10 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 3.0488208633056e-06 3.44323181625704e-05 1.48847280390866 0.612244897959184 10.1 10 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00474401590766947 0.0167928722303822 1.48571637279031 0.611111111111111 10.1 10 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.00152885408055584 0.00683286188385237 1.47984397605991 0.608695652173913 10.1 10 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00152885408055584 0.00683286188385237 1.47984397605991 0.608695652173913 10.1 10 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000502339478506203 0.00275089734106556 1.47606886387609 0.607142857142857 10.1 10 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.000502339478506203 0.00275089734106556 1.47606886387609 0.607142857142857 10.1 10 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 7.56445183993025e-11 2.19677856494301e-09 1.4734377250813 0.606060606060606 10.1 10 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.000167251107060018 0.00109173543736883 1.4734377250813 0.606060606060606 10.1 10 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 1.53274582053254e-09 3.02930180919139e-08 1.47001112572064 0.604651162790698 10.1 10 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 1.90359939998417e-05 0.00017096546727267 1.47001112572064 0.604651162790698 10.1 10 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 1.90359939998417e-05 0.00017096546727267 1.47001112572064 0.604651162790698 10.1 10 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 7.61140592526554e-07 9.25729113816484e-06 1.46708670040422 0.603448275862069 10.1 10 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 7.61140592526554e-07 9.25729113816484e-06 1.46708670040422 0.603448275862069 10.1 10 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 9.24193845142765e-09 1.62361461930636e-07 1.45870334783048 0.6 10.1 10 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 4.75201440526722e-05 0.000386406657068301 1.45870334783048 0.6 10.1 10 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.00127928740993837 0.00603510549505522 1.45870334783048 0.6 10.1 10 1 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.0413271279187761 0.0921763370351386 1.45870334783048 0.6 10.1 10 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 2.45796789456334e-13 1.84088858629665e-11 1.45870334783048 0.6 10.1 10 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.61190897341801e-05 0.000150904372971962 1.45870334783048 0.6 10.1 10 1 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 1.61190897341801e-05 0.000150904372971962 1.45870334783048 0.6 10.1 10 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000141032921535509 0.00101916114554812 1.45870334783048 0.6 10.1 10 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000141032921535509 0.00101916114554812 1.45870334783048 0.6 10.1 10 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 3.88487713509182e-10 8.80968115935637e-09 1.45870334783048 0.6 10.1 10 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 3.88487713509182e-10 8.80968115935637e-09 1.45870334783048 0.6 10.1 10 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.0124730938836344 0.0347572527507944 1.45870334783048 0.6 10.1 10 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 3.01450612059043e-12 1.75294738132195e-10 1.44289084541498 0.59349593495935 10.1 10 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 3.92134544873586e-06 4.19554479214371e-05 1.44069466452394 0.592592592592593 10.1 10 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00106595066260118 0.00519468422219683 1.44069466452394 0.592592592592593 10.1 10 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00106595066260118 0.00519468422219683 1.44069466452394 0.592592592592593 10.1 10 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00106595066260118 0.00519468422219683 1.44069466452394 0.592592592592593 10.1 10 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 3.36387505386138e-05 0.000281576129508515 1.43660178195427 0.590909090909091 10.1 10 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00326146629512021 0.0125096133098546 1.43660178195427 0.590909090909091 10.1 10 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.00326146629512021 0.0125096133098546 1.43660178195427 0.590909090909091 10.1 10 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 1.7136268479109e-10 4.68940577803309e-09 1.43554932643635 0.59047619047619 10.1 10 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 5.24041177038777e-12 1.91207844852867e-10 1.4312546289197 0.588709677419355 10.1 10 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 5.24041177038777e-12 1.91207844852867e-10 1.4312546289197 0.588709677419355 10.1 10 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 5.24041177038777e-12 1.91207844852867e-10 1.4312546289197 0.588709677419355 10.1 10 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.000295114327826101 0.00179464824143821 1.43010132140244 0.588235294117647 10.1 10 1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0102004788415298 0.0290305627829938 1.43010132140244 0.588235294117647 10.1 10 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0102004788415298 0.0290305627829938 1.43010132140244 0.588235294117647 10.1 10 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0102004788415298 0.0290305627829938 1.43010132140244 0.588235294117647 10.1 10 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 3.50378526096919e-10 8.45065495993077e-09 1.42597602912916 0.586538461538462 10.1 10 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.000885313300268952 0.00446737881660539 1.42516993753553 0.586206896551724 10.1 10 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.03324822650191e-10 2.94062445262444e-09 1.42365942355828 0.585585585585586 10.1 10 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 8.29783760314734e-05 0.000638260697798846 1.42312521739559 0.585365853658537 10.1 10 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.000245710433914992 0.00152683819851979 1.41818381039075 0.583333333333333 10.1 10 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000245710433914992 0.00152683819851979 1.41818381039075 0.583333333333333 10.1 10 1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.00268952691956353 0.0107808360747575 1.41818381039075 0.583333333333333 10.1 10 1 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0330783364164951 0.0773004298577237 1.41818381039075 0.583333333333333 10.1 10 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.000733428711758757 0.0038229635781418 1.41164840112628 0.580645161290323 10.1 10 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.000733428711758757 0.0038229635781418 1.41164840112628 0.580645161290323 10.1 10 1 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.00832038409898993 0.0249787058499212 1.4075207742224 0.578947368421053 10.1 10 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 5.76130232183656e-05 0.000463182666891154 1.40467729791084 0.577777777777778 10.1 10 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 1.64199126846744e-05 0.000151724258118777 1.40259937291393 0.576923076923077 10.1 10 1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 1.64199126846744e-05 0.000151724258118777 1.40259937291393 0.576923076923077 10.1 10 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.00221276189420375 0.00918005882055956 1.40259937291393 0.576923076923077 10.1 10 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 6.85063639246204e-18 9.74845558647349e-16 1.40081829434515 0.576190476190476 10.1 10 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000606388968327071 0.00325619434690348 1.39976583882723 0.575757575757576 10.1 10 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 7.31932109028046e-11 2.16987373155606e-09 1.39493489546631 0.573770491803279 10.1 10 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 48%5605570 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0264806490241659 0.0656480201417911 1.38924128364808 0.571428571428571 10.1 10 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 7.83677978108224e-06 7.85333635808452e-05 1.37766427295101 0.566666666666667 10.1 10 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00551386217405388 0.0185929523072954 1.37414083491278 0.565217391304348 10.1 10 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.76579827194485e-09 5.31855532564529e-08 1.37316210212438 0.564814814814815 10.1 10 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 7.3134946281934e-13 5.20355142795961e-11 1.36753438859108 0.5625 10.1 10 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.0212179680152373 0.055194942824108 1.36753438859108 0.5625 10.1 10 1 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 0.0212179680152373 0.055194942824108 1.36753438859108 0.5625 10.1 10 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.0212179680152373 0.055194942824108 1.36753438859108 0.5625 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.000279653017924344 0.00171528553666527 1.36382833333744 0.560975609756098 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.000279653017924344 0.00171528553666527 1.36382833333744 0.560975609756098 10.1 10 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 5.41395845536932e-09 9.7519783316336e-08 1.36327415685092 0.560747663551402 10.1 10 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.00448437720454103 0.0161551107900301 1.36145645797512 0.56 10.1 10 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00100067017962831 0.00497885897066811 1.35859625533231 0.558823529411765 10.1 10 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 1.77720446785382e-07 2.52896195775598e-06 1.35372090991844 0.556818181818182 10.1 10 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 3.57773710942904e-08 5.72035944575003e-07 1.35065124799119 0.555555555555556 10.1 10 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 1.47169213715003e-07 2.13695705220867e-06 1.35065124799119 0.555555555555556 10.1 10 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000819113414086754 0.00420793641965867 1.35065124799119 0.555555555555556 10.1 10 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0170210575088552 0.0454537822094831 1.35065124799119 0.555555555555556 10.1 10 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0170210575088552 0.0454537822094831 1.35065124799119 0.555555555555556 10.1 10 1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS%REACTOME%REACT_225645.1 DEPOLARIZATION OF THE PRESYNAPTIC TERMINAL TRIGGERS THE OPENING OF CALCIUM CHANNELS 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.0886400877093631 0.16773250639684 1.35065124799119 0.555555555555556 10.1 10 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.00364627593370696 0.0135473907406397 1.35065124799119 0.555555555555556 10.1 10 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.000670243992198006 0.00354556580259391 1.34354255721229 0.552631578947368 10.1 10 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000670243992198006 0.00354556580259391 1.34354255721229 0.552631578947368 10.1 10 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.43424782859814e-07 4.56722865429454e-06 1.34133641179815 0.551724137931034 10.1 10 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.000104635016494782 0.000796233307337302 1.33476123330894 0.549019607843137 10.1 10 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 2.03565887014734e-05 0.000181046410763729 1.33322348995259 0.548387096774194 10.1 10 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.000448423180796536 0.00252215883902558 1.33135623016274 0.547619047619048 10.1 10 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.59704695593181e-07 2.29555335180906e-06 1.33074691381027 0.547368421052632 10.1 10 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 1.67419630723521e-05 0.00015370202227069 1.32954732224133 0.546875 10.1 10 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 0.000366704405646974 0.00212017666241947 1.32609395257317 0.545454545454545 10.1 10 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 0.000366704405646974 0.00212017666241947 1.32609395257317 0.545454545454545 10.1 10 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00196038476650418 0.00832724633652374 1.32609395257317 0.545454545454545 10.1 10 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0109941979495617 0.0310411580996553 1.32609395257317 0.545454545454545 10.1 10 1 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605600 P2Y RECEPTORS 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0688996153074993 0.139664035017908 1.32609395257317 0.545454545454545 10.1 10 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 2.19040004578623e-08 3.58268881052162e-07 1.32609395257317 0.545454545454545 10.1 10 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 0.00159455552701665 0.00706869942350369 1.31977921946568 0.542857142857143 10.1 10 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 3.4633096515517e-15 4.10690802846506e-13 1.31915624131157 0.542600896860987 10.1 10 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.000245177345464294 0.00152683819851979 1.31688496679141 0.541666666666667 10.1 10 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.00885171292936066 0.0261761207929621 1.31688496679141 0.541666666666667 10.1 10 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.00885171292936066 0.0261761207929621 1.31688496679141 0.541666666666667 10.1 10 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00885171292936066 0.0261761207929621 1.31688496679141 0.541666666666667 10.1 10 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.00129728764153169 0.00603510549505522 1.31414716020764 0.540540540540541 10.1 10 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00129728764153169 0.00603510549505522 1.31414716020764 0.540540540540541 10.1 10 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 2.61373850983133e-05 0.000226789628017682 1.309092748053 0.538461538461538 10.1 10 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00713459506660116 0.0223581240589089 1.309092748053 0.538461538461538 10.1 10 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0539529564166137 0.113070776113168 1.309092748053 0.538461538461538 10.1 10 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 5.64457298189913e-28 2.67740911774749e-25 1.30825412361478 0.538116591928251 10.1 10 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 5.96271819299124e-14 5.30309249289158e-12 1.30820220876861 0.538095238095238 10.1 10 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 2.14300678985478e-05 0.000189409854780332 1.30630150551984 0.537313432835821 10.1 10 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.000134028379125143 0.000993345747370203 1.30562953972482 0.537037037037037 10.1 10 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000859322498775687 0.00437760686019523 1.3045314492793 0.536585365853659 10.1 10 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 9.02581906896289e-17 1.16761277592129e-14 1.30407706702598 0.53639846743295 10.1 10 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 1.75696933813742e-05 0.000160267138985227 1.30367207414802 0.536231884057971 10.1 10 1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.0057564801940675 0.0189179476123743 1.30241370342008 0.535714285714286 10.1 10 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 1.44042011411495e-05 0.000138271693018728 1.30119077975489 0.535211267605634 10.1 10 1 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.00464898719261239 0.0166218813444408 1.29662519807154 0.533333333333333 10.1 10 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00464898719261239 0.0166218813444408 1.29662519807154 0.533333333333333 10.1 10 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00464898719261239 0.0166218813444408 1.29662519807154 0.533333333333333 10.1 10 1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0424892834704876 0.0940314935902082 1.29662519807154 0.533333333333333 10.1 10 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.000464186489774713 0.00259001562917603 1.29317672680008 0.531914893617021 10.1 10 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 4.902948867867e-05 0.000396414559032656 1.29156025589157 0.53125 10.1 10 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.00375788059760731 0.0139256877354042 1.29156025589157 0.53125 10.1 10 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.000378237653258305 0.0021690580379378 1.2900097633875 0.530612244897959 10.1 10 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00304006367673956 0.0119173846060617 1.28709118926219 0.529411764705882 10.1 10 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.00304006367673956 0.0119173846060617 1.28709118926219 0.529411764705882 10.1 10 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00304006367673956 0.0119173846060617 1.28709118926219 0.529411764705882 10.1 10 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0336126433356583 0.0780273922783716 1.28709118926219 0.529411764705882 10.1 10 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.00246122612382065 0.00992159992690307 1.28311868559163 0.527777777777778 10.1 10 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.47046724663111e-05 0.000139498326130405 1.27956434020218 0.526315789473684 10.1 10 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0266884724087055 0.0658192309143637 1.27956434020218 0.526315789473684 10.1 10 1 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.0266884724087055 0.0658192309143637 1.27956434020218 0.526315789473684 10.1 10 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0266884724087055 0.0658192309143637 1.27956434020218 0.526315789473684 10.1 10 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000111275121201242 0.000837801573911995 1.27536904728348 0.524590163934426 10.1 10 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000111275121201242 0.000837801573911995 1.27536904728348 0.524590163934426 10.1 10 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0212556772084408 0.055194942824108 1.27347117667741 0.523809523809524 10.1 10 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 9.08182060235445e-05 0.000694808103072601 1.27347117667741 0.523809523809524 10.1 10 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 3.6215384188948e-06 3.93393066418878e-05 1.26961217311172 0.522222222222222 10.1 10 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 2.07042880870035e-11 6.69972784035813e-10 1.26623554499174 0.520833333333333 10.1 10 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000570820926735435 0.0030885101853404 1.26420956811975 0.52 10.1 10 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0135829932979153 0.0372420028187542 1.26420956811975 0.52 10.1 10 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.0135829932979153 0.0372420028187542 1.26420956811975 0.52 10.1 10 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.0135829932979153 0.0372420028187542 1.26420956811975 0.52 10.1 10 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 0.000307348552475048 0.00185320758547455 1.25899991330607 0.517857142857143 10.1 10 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.00874772088033742 0.0260964503411324 1.25750288606076 0.517241379310345 10.1 10 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.000203792802534198 0.001283173265514 1.25610566063181 0.516666666666667 10.1 10 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.00703658965707343 0.0223505961652131 1.25479857877891 0.516129032258065 10.1 10 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00703658965707343 0.0223505961652131 1.25479857877891 0.516129032258065 10.1 10 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00703658965707343 0.0223505961652131 1.25479857877891 0.516129032258065 10.1 10 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 8.6807103191785e-10 1.82594162010876e-08 1.25155020967704 0.514792899408284 10.1 10 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 7.33516739861148e-05 0.000573330367488405 1.25031715528327 0.514285714285714 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.98410646077101e-05 0.000478392331105458 1.24935240439185 0.513888888888889 10.1 10 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 3.98545560522269e-05 0.000327821001516294 1.24757523169712 0.513157894736842 10.1 10 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.00298169103093581 0.01181879202513 1.24675499814571 0.512820512820513 10.1 10 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.00298169103093581 0.01181879202513 1.24675499814571 0.512820512820513 10.1 10 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.42479791465897e-09 6.41248346389436e-08 1.24597577627187 0.5125 10.1 10 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 2.67242218164188e-07 3.67531460348215e-06 1.24572462211419 0.512396694214876 10.1 10 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 2.67242218164188e-07 3.67531460348215e-06 1.24572462211419 0.512396694214876 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.00241159816775971 0.0097769350220002 1.24523456522115 0.51219512195122 10.1 10 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 1.27101888801409e-09 2.58379982520579e-08 1.24418814962012 0.511764705882353 10.1 10 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 1.20356176677912e-07 1.76563751971824e-06 1.24385556791747 0.511627906976744 10.1 10 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.44782025718837e-05 0.000138271693018728 1.24385556791747 0.511627906976744 10.1 10 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00195209008583484 0.00832724633652374 1.24385556791747 0.511627906976744 10.1 10 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.3422791808096e-26 3.82012654858413e-24 1.24331812600254 0.511406844106464 10.1 10 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 3.5321290593481e-06 3.89292156152455e-05 1.23989784565591 0.51 10.1 10 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.88550777613274e-21 2.98119729492988e-19 1.23841403160882 0.509389671361502 10.1 10 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 4.0923339073737e-09 7.46588608999074e-08 1.23795887392567 0.50920245398773 10.1 10 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.000556745196249105 0.00302384890939876 1.23768768906829 0.509090909090909 10.1 10 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 4.10698851647043e-15 4.49557281456725e-13 1.23632991369023 0.508532423208191 10.1 10 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.000368013798747441 0.00212017666241947 1.23618927782244 0.508474576271186 10.1 10 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.000368013798747441 0.00212017666241947 1.23618927782244 0.508474576271186 10.1 10 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.000299394406578254 0.00181292868323768 1.23551376455587 0.508196721311475 10.1 10 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000131629051405664 0.000980670890839053 1.23320331338326 0.507246376811594 10.1 10 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 3.87156260067406e-05 0.000320304277951115 1.23059335928086 0.506172839506173 10.1 10 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 6.77645514796481e-24 1.37755652507913e-21 1.23041034420661 0.50609756097561 10.1 10 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 2.28937359585885e-11 7.23950805979365e-10 1.22663690613018 0.504545454545455 10.1 10 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.32647926825005e-13 1.11034117571755e-11 1.22452425645084 0.503676470588235 10.1 10 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.13682082087219e-07 1.685100029272e-06 1.22433134709993 0.503597122302158 10.1 10 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 3.62095151007044e-07 4.68419454439112e-06 1.21558612319207 0.5 10.1 10 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000654867324066028 0.00350329399302992 1.21558612319207 0.5 10.1 10 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00150866358461544 0.00679376038261953 1.21558612319207 0.5 10.1 10 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0315171564673199 0.0745659958928654 1.21558612319207 0.5 10.1 10 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0397056800744139 0.0901135291003046 1.21558612319207 0.5 10.1 10 1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 48%5605602 REDUCTION OF CYTOSOLIC CA++ LEVELS 0.13595304749995 0.236794598032349 1.21558612319207 0.5 10.1 10 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 0.000154700497145744 0.00101916114554812 1.21558612319207 0.5 10.1 10 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000806141840023162 0.00417141759401076 1.21558612319207 0.5 10.1 10 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000992870621260238 0.00495738559316954 1.21558612319207 0.5 10.1 10 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00186144395765804 0.00797841792694996 1.21558612319207 0.5 10.1 10 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.00351188458696666 0.0130822297572083 1.21558612319207 0.5 10.1 10 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00538565290279328 0.0183607898291411 1.21558612319207 0.5 10.1 10 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00667997731142465 0.0216666172332931 1.21558612319207 0.5 10.1 10 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.00667997731142465 0.0216666172332931 1.21558612319207 0.5 10.1 10 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00829537615956909 0.0249562796513041 1.21558612319207 0.5 10.1 10 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.0128464545680624 0.0354273349813039 1.21558612319207 0.5 10.1 10 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0200313915292293 0.0525916423359656 1.21558612319207 0.5 10.1 10 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0200313915292293 0.0525916423359656 1.21558612319207 0.5 10.1 10 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.0250937792072342 0.063312850730309 1.21558612319207 0.5 10.1 10 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0502042291624615 0.10890338124723 1.21558612319207 0.5 10.1 10 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.063760598925738 0.131527293553591 1.21558612319207 0.5 10.1 10 1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.063760598925738 0.131527293553591 1.21558612319207 0.5 10.1 10 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.063760598925738 0.131527293553591 1.21558612319207 0.5 10.1 10 1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0814252638090616 0.160482202770491 1.21558612319207 0.5 10.1 10 1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.104720894198504 0.193028280368485 1.21558612319207 0.5 10.1 10 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 3.53320751380305e-09 6.52955102875551e-08 1.2089435760708 0.497267759562842 10.1 10 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 6.46995246472997e-05 0.000513540674165898 1.20128510997805 0.494117647058824 10.1 10 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.000331870664370124 0.00195955168215223 1.19796893300088 0.492753623188406 10.1 10 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.000407689211988571 0.00231132170780772 1.19744304672652 0.492537313432836 10.1 10 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.000407689211988571 0.00231132170780772 1.19744304672652 0.492537313432836 10.1 10 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 5.34463690938302e-42 7.60541832205204e-39 1.1973340793003 0.492492492492492 10.1 10 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 8.57512572475975e-09 1.52530048829164e-07 1.19565848182827 0.491803278688525 10.1 10 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000757564203072723 0.00393435715683389 1.19565848182827 0.491803278688525 10.1 10 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00141342013823528 0.00638506938637713 1.19348455731585 0.490909090909091 10.1 10 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00141342013823528 0.00638506938637713 1.19348455731585 0.490909090909091 10.1 10 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00141342013823528 0.00638506938637713 1.19348455731585 0.490909090909091 10.1 10 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 3.32485281472488e-22 5.91408194419187e-20 1.18826958109787 0.48876404494382 10.1 10 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.88225767032028e-07 3.90614539511025e-06 1.18359701468702 0.486842105263158 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.00951275048055005 0.0276112944832307 1.18273244418688 0.486486486486487 10.1 10 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.00951275048055005 0.0276112944832307 1.18273244418688 0.486486486486487 10.1 10 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00951275048055005 0.0276112944832307 1.18273244418688 0.486486486486487 10.1 10 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.00037954704950563 0.0021690580379378 1.18181984199229 0.486111111111111 10.1 10 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.69258794680926e-08 5.83839183145508e-07 1.18124753214145 0.485875706214689 10.1 10 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 9.52073870580845e-07 1.13848833431642e-05 1.18085509110087 0.485714285714286 10.1 10 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 9.52073870580845e-07 1.13848833431642e-05 1.18085509110087 0.485714285714286 10.1 10 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000465947997940312 0.00259001562917603 1.18085509110087 0.485714285714286 10.1 10 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.000702944281400317 0.00369110594993598 1.17875018006504 0.484848484848485 10.1 10 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0146894905267845 0.0399677725040427 1.17875018006504 0.484848484848485 10.1 10 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0146894905267845 0.0399677725040427 1.17875018006504 0.484848484848485 10.1 10 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 3.60941236451292e-11 1.0928071903621e-09 1.1781834732477 0.484615384615385 10.1 10 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.000863874284783678 0.00437760686019523 1.17759905684232 0.484375 10.1 10 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.2023118345504e-07 3.10286112927249e-06 1.17736014447534 0.484276729559748 10.1 10 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 2.68610484021183e-07 3.67531460348215e-06 1.17687318933245 0.484076433121019 10.1 10 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 3.27629948949863e-07 4.39827752222317e-06 1.17637366760523 0.483870967741935 10.1 10 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00106206757330662 0.00519468422219683 1.17637366760523 0.483870967741935 10.1 10 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0182932029221146 0.0483557933332545 1.17637366760523 0.483870967741935 10.1 10 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.00130628176963159 0.00605485002666369 1.17506658575233 0.483333333333333 10.1 10 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00160737387701168 0.00710339449375036 1.17366936032338 0.482758620689655 10.1 10 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.60746197977445e-06 1.89042842745376e-05 1.17186000365279 0.482014388489209 10.1 10 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.000190119343564313 0.00120239922618674 1.17164927536585 0.481927710843373 10.1 10 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.000190119343564313 0.00120239922618674 1.17164927536585 0.481927710843373 10.1 10 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00243735010000927 0.00985326475088975 1.1705644149257 0.481481481481481 10.1 10 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.0285186691116327 0.0686667785885843 1.1705644149257 0.481481481481481 10.1 10 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.70484927212434e-07 4.74955001282247e-06 1.169424624843 0.481012658227848 10.1 10 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.000285505982871646 0.00174366958637919 1.169424624843 0.481012658227848 10.1 10 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.000429160726934727 0.00242339569217507 1.16696267826439 0.48 10.1 10 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.10343594337934e-09 4.10025938003946e-08 1.16652659355652 0.479820627802691 10.1 10 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 7.91352609162482e-06 7.87478855131616e-05 1.16617205314361 0.479674796747967 10.1 10 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 1.34931685826965e-14 1.28005192621181e-12 1.16358243877744 0.478609625668449 10.1 10 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0448495326664238 0.0986412441797852 1.1627345526185 0.478260869565217 10.1 10 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0448495326664238 0.0986412441797852 1.1627345526185 0.478260869565217 10.1 10 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.02804364870719e-06 1.21908842675861e-05 1.15324837328478 0.474358974358974 10.1 10 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.000588542028745222 0.0031723307079714 1.15160790618196 0.473684210526316 10.1 10 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.0713684102408421 0.144257454222611 1.15160790618196 0.473684210526316 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 3.57628574302385e-05 0.000297605532884382 1.15046543802107 0.473214285714286 10.1 10 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.000159263529125918 0.00104438710574277 1.15023203054734 0.473118279569892 10.1 10 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00335535627263424 0.0125980790922389 1.14928142556341 0.472727272727273 10.1 10 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.20706783009915e-05 0.000117847682090039 1.14858531325235 0.47244094488189 10.1 10 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.00413051804531638 0.0151487813878485 1.14677936150195 0.471698113207547 10.1 10 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00413051804531638 0.0151487813878485 1.14677936150195 0.471698113207547 10.1 10 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00108377723949203 0.00526353246347154 1.14612405900967 0.471428571428571 10.1 10 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0203731477420871 0.0533904037513627 1.14408105712195 0.470588235294118 10.1 10 1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0905587816724755 0.170682313006533 1.14408105712195 0.470588235294118 10.1 10 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0905587816724755 0.170682313006533 1.14408105712195 0.470588235294118 10.1 10 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.0905587816724755 0.170682313006533 1.14408105712195 0.470588235294118 10.1 10 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.000118365789098726 0.000886497462565718 1.14265095580055 0.47 10.1 10 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.000144534086946875 0.00101916114554812 1.14116248299664 0.469387755102041 10.1 10 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.94792591367056e-05 0.000249696343759119 1.13587555773685 0.467213114754098 10.1 10 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 5.58470727918392e-08 8.73300929481178e-07 1.1345470483126 0.466666666666667 10.1 10 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.00953765248120864 0.0276112944832307 1.1345470483126 0.466666666666667 10.1 10 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0315451367023928 0.0745659958928654 1.1345470483126 0.466666666666667 10.1 10 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.115494246605314 0.209627950152247 1.1345470483126 0.466666666666667 10.1 10 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 3.55308929950284e-07 4.63857437907572e-06 1.13108013601829 0.46524064171123 10.1 10 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 6.49594668656793e-05 0.000513540674165898 1.13028183384526 0.464912280701754 10.1 10 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.66182900649377e-05 0.000229562586438827 1.12944222469814 0.464566929133858 10.1 10 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 3.71461984396579e-06 4.00447275603282e-05 1.12931872090102 0.464516129032258 10.1 10 1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0393456380130616 0.0901135291003046 1.12875854296407 0.464285714285714 10.1 10 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 2.26876237836999e-06 2.60358779388749e-05 1.12664079710485 0.463414634146341 10.1 10 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.01454947049742 0.0397387649094601 1.12664079710485 0.463414634146341 10.1 10 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 1.47080881790686e-24 3.48826824646911e-22 1.12375567342468 0.462227912932138 10.1 10 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 1.24398974677476e-09 2.56550349226157e-08 1.12342977450242 0.462093862815884 10.1 10 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.9020392813119e-27 6.76650474326708e-25 1.12207949833114 0.461538461538462 10.1 10 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.19833063582828e-05 0.000117847682090039 1.12207949833114 0.461538461538462 10.1 10 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.00687324871375214 0.0220284525217777 1.12207949833114 0.461538461538462 10.1 10 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.0491657444900707 0.107801008334932 1.12207949833114 0.461538461538462 10.1 10 1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.148236269440123 0.255995402200601 1.12207949833114 0.461538461538462 10.1 10 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000525053173569577 0.00286264622984486 1.11997822586236 0.460674157303371 10.1 10 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 0.00329748076106549 0.0125245701168094 1.11911103404984 0.46031746031746 10.1 10 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00845437042081096 0.0252743048504496 1.11833923333671 0.46 10.1 10 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00845437042081096 0.0252743048504496 1.11833923333671 0.46 10.1 10 1 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.0222654819958184 0.0569852174101611 1.1170250861765 0.459459459459459 10.1 10 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.1758872173446e-05 0.000267413462146827 1.11504892503333 0.458646616541353 10.1 10 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00195503813237697 0.00832724633652374 1.11428727959273 0.458333333333333 10.1 10 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.0104037854330266 0.0295500731960018 1.11428727959273 0.458333333333333 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.061565939439584 0.128457964549161 1.11428727959273 0.458333333333333 10.1 10 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.061565939439584 0.128457964549161 1.11428727959273 0.458333333333333 10.1 10 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.0049549286923506 0.0174095395783084 1.1125703500402 0.457627118644068 10.1 10 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0275815090507297 0.0668109075365196 1.11139302691846 0.457142857142857 10.1 10 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0275815090507297 0.0668109075365196 1.11139302691846 0.457142857142857 10.1 10 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 1.5383499568259e-10 4.29229801679069e-09 1.11117995310195 0.457055214723926 10.1 10 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.00116392152663285 0.00561444180474083 1.11053547057053 0.45679012345679 10.1 10 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0128086624813166 0.0353917023512885 1.10988298204493 0.456521739130435 10.1 10 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 1.9890957525038e-08 3.29125959978245e-07 1.10946352513562 0.456349206349206 10.1 10 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 1.9890957525038e-08 3.29125959978245e-07 1.10946352513562 0.456349206349206 10.1 10 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 1.9890957525038e-08 3.29125959978245e-07 1.10946352513562 0.456349206349206 10.1 10 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 8.46528355173979e-08 1.28149983980061e-06 1.10602685887004 0.454935622317597 10.1 10 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.000847117208845742 0.00433614312297658 1.10507829381097 0.454545454545455 10.1 10 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.0074524700108243 0.0230540539682673 1.10507829381097 0.454545454545455 10.1 10 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.015777224781337 0.0423603601204576 1.10507829381097 0.454545454545455 10.1 10 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.0342017298586139 0.0792655726202078 1.10507829381097 0.454545454545455 10.1 10 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.0772794545236145 0.154189234346477 1.10507829381097 0.454545454545455 10.1 10 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%REACT_199084.2 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.191830907660326 0.312686576862135 1.10507829381097 0.454545454545455 10.1 10 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00437223976930354 0.0159940801843674 1.10162492414281 0.453125 10.1 10 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00153175189103929 0.00683286188385237 1.09699235507577 0.451219512195122 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.0239761884948892 0.0612533504995104 1.09402751087286 0.45 10.1 10 1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.0972742803770105 0.18165525062531 1.09402751087286 0.45 10.1 10 1 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.0972742803770105 0.18165525062531 1.09402751087286 0.45 10.1 10 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.0972742803770105 0.18165525062531 1.09402751087286 0.45 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.0527734623039137 0.111750947706055 1.08983583458599 0.448275862068966 10.1 10 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00135009698773965 0.00615765388959461 1.08983583458599 0.448275862068966 10.1 10 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00135009698773965 0.00615765388959461 1.08983583458599 0.448275862068966 10.1 10 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.90828874062003e-06 3.31079590232184e-05 1.0889625686929 0.447916666666667 10.1 10 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.0295822364158128 0.0708678828614505 1.08762968917185 0.447368421052632 10.1 10 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00164192258168596 0.00714512487381992 1.08687700426585 0.447058823529412 10.1 10 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.122842423680487 0.222115335320626 1.08052099839295 0.444444444444444 10.1 10 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.122842423680487 0.222115335320626 1.08052099839295 0.444444444444444 10.1 10 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00698876940879331 0.0223483570083435 1.08052099839295 0.444444444444444 10.1 10 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0656834047928214 0.134292363534748 1.08052099839295 0.444444444444444 10.1 10 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.001042447793643 0.00516865230088499 1.07773615045895 0.443298969072165 10.1 10 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.00175042783216542 0.00759408172308352 1.0774513364657 0.443181818181818 10.1 10 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.00500095494271026 0.0175279775455091 1.07666199482726 0.442857142857143 10.1 10 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 1.91029580438191e-05 0.00017096546727267 1.07423889956509 0.441860465116279 10.1 10 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 0.000661407910718334 0.00352503167397824 1.07060796171045 0.440366972477064 10.1 10 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.22803461496932e-05 0.000118877092319819 1.07024430411476 0.440217391304348 10.1 10 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00110643401139243 0.00535529115037901 1.06971578840902 0.44 10.1 10 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0818741546769245 0.160699202903812 1.06971578840902 0.44 10.1 10 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.0818741546769245 0.160699202903812 1.06971578840902 0.44 10.1 10 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.0818741546769245 0.160699202903812 1.06971578840902 0.44 10.1 10 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.50517793339908e-07 4.61839648076564e-06 1.06780898664715 0.43921568627451 10.1 10 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00312869605568566 0.0122311387012107 1.0673439130467 0.439024390243902 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.0313536199711695 0.0743603353649571 1.0673439130467 0.439024390243902 10.1 10 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.0313536199711695 0.0743603353649571 1.0673439130467 0.439024390243902 10.1 10 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00529720582794633 0.0183607898291411 1.06571934088072 0.438356164383562 10.1 10 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0557786879772297 0.116725107340585 1.06363785779306 0.4375 10.1 10 1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.155731528133873 0.261636321764464 1.06363785779306 0.4375 10.1 10 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 3.80357371032343e-12 1.75294738132195e-10 1.06087516205853 0.436363636363636 10.1 10 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.0385391784322561 0.088453630498549 1.05974174842386 0.435897435897436 10.1 10 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.0109823826665244 0.0310411580996553 1.05873630084471 0.435483870967742 10.1 10 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00330057188601793 0.0125245701168094 1.0582749778378 0.435294117647059 10.1 10 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00330057188601793 0.0125245701168094 1.0582749778378 0.435294117647059 10.1 10 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.000320892342211214 0.00190262417902732 1.0578383056786 0.435114503816794 10.1 10 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.000320892342211214 0.00190262417902732 1.0578383056786 0.435114503816794 10.1 10 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 0.0023719024117537 0.0097769350220002 1.05703141147137 0.434782608695652 10.1 10 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.00781561003627632 0.0237566790119178 1.05703141147137 0.434782608695652 10.1 10 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0268921288830726 0.0660923996556343 1.05703141147137 0.434782608695652 10.1 10 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0268921288830726 0.0660923996556343 1.05703141147137 0.434782608695652 10.1 10 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.102225548259915 0.190401773787773 1.05703141147137 0.434782608695652 10.1 10 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.102225548259915 0.190401773787773 1.05703141147137 0.434782608695652 10.1 10 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 1.84925317432247e-13 1.46193737058938e-11 1.05592069545231 0.434325744308231 10.1 10 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0690068877639002 0.139682505388378 1.05350797343313 0.433333333333333 10.1 10 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.000465576651425638 0.00259001562917603 1.05286987048132 0.433070866141732 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00948973345813049 0.0276112944832307 1.05229843500209 0.432835820895522 10.1 10 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00676397025045795 0.021727155003164 1.05131772816612 0.432432432432432 10.1 10 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00676397025045795 0.021727155003164 1.05131772816612 0.432432432432432 10.1 10 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 1.27091239741631e-14 1.28005192621181e-12 1.05111335069174 0.432348367029549 10.1 10 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00819560105287097 0.0247083480894818 1.04675471719317 0.430555555555556 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00819560105287097 0.0247083480894818 1.04675471719317 0.430555555555556 10.1 10 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00585066901203811 0.0191831843413139 1.04632729591216 0.430379746835443 10.1 10 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00216132862708668 0.00899289659749807 1.04540406594518 0.43 10.1 10 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00155694991533361 0.00692356165474913 1.04517685358571 0.429906542056075 10.1 10 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 2.35350671329168e-32 1.67452002650703e-29 1.04372468937731 0.429309231762427 10.1 10 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0281201826018084 0.0678220675294464 1.04193096273606 0.428571428571429 10.1 10 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0854367298776409 0.16384968546615 1.04193096273606 0.428571428571429 10.1 10 1 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.19834452366342 0.31971553225812 1.04193096273606 0.428571428571429 10.1 10 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.12787118319534 0.22974835061486 1.04193096273606 0.428571428571429 10.1 10 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.01201833870479 0.0338655365879527 1.03682345801677 0.426470588235294 10.1 10 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 4.11739611807478e-06 4.3724288627018e-05 1.0349568599065 0.42570281124498 10.1 10 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.00377945955650717 0.0139692751919733 1.03454138144006 0.425531914893617 10.1 10 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.0493031275163969 0.107935923778204 1.03324820471326 0.425 10.1 10 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.0205567401378774 0.0537725022356609 1.0301577315187 0.423728813559322 10.1 10 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.0088888993144235 0.0261761207929621 1.02857287347021 0.423076923076923 10.1 10 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0292105299836775 0.0700954201800558 1.02857287347021 0.423076923076923 10.1 10 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0292105299836775 0.0700954201800558 1.02857287347021 0.423076923076923 10.1 10 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.105860322147284 0.194876116967122 1.02857287347021 0.423076923076923 10.1 10 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.0124813465605453 0.0347572527507944 1.02725587875386 0.422535211267606 10.1 10 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0417913248688927 0.0930658142229019 1.0264949484733 0.422222222222222 10.1 10 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.0107152579676296 0.0303741276652131 1.02365147216174 0.421052631578947 10.1 10 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0249123483746121 0.0629667348793482 1.02365147216174 0.421052631578947 10.1 10 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.16027806981841 0.268009040366154 1.02365147216174 0.421052631578947 10.1 10 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.16027806981841 0.268009040366154 1.02365147216174 0.421052631578947 10.1 10 1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.16027806981841 0.268009040366154 1.02365147216174 0.421052631578947 10.1 10 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00920286288666353 0.027001389459221 1.02049205403779 0.419753086419753 10.1 10 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0881807277527319 0.16773250639684 1.01952384525787 0.419354838709677 10.1 10 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00790720324694723 0.0239403196178849 1.01770001011429 0.418604651162791 10.1 10 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 0.00302339856143976 0.0119173846060617 1.0166720303061 0.418181818181818 10.1 10 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.0301744265467776 0.0721650571026294 1.0166720303061 0.418181818181818 10.1 10 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0430821432879762 0.0950478913159536 1.01298843599339 0.416666666666667 10.1 10 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.0430821432879762 0.0950478913159536 1.01298843599339 0.416666666666667 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0738081392394673 0.148977279628031 1.01298843599339 0.416666666666667 10.1 10 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.131268125988722 0.235257611186337 1.01298843599339 0.416666666666667 10.1 10 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.131268125988722 0.235257611186337 1.01298843599339 0.416666666666667 10.1 10 1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 GABA A RECEPTOR ACTIVATION%REACTOME%REACT_198560.2 GABA A RECEPTOR ACTIVATION 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.254052345847341 0.373082031105023 1.01298843599339 0.416666666666667 10.1 10 1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.0365254182462112 0.0843760879291534 1.00916583812172 0.415094339622642 10.1 10 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0365254182462112 0.0843760879291534 1.00916583812172 0.415094339622642 10.1 10 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.031022513695184 0.0738211320873693 1.00600230884861 0.413793103448276 10.1 10 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.031022513695184 0.0738211320873693 1.00600230884861 0.413793103448276 10.1 10 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.031022513695184 0.0738211320873693 1.00600230884861 0.413793103448276 10.1 10 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.00444672804290705 0.0161551107900301 1.00369496410354 0.412844036697248 10.1 10 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 0.00329285692174919 0.0125245701168094 1.00107092498171 0.411764705882353 10.1 10 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.201352450656851 0.319984670354879 1.0010709249817 0.411764705882353 10.1 10 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 0.00283517958010518 0.0113327543328362 0.999917617464445 0.411290322580645 10.1 10 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.162896226121919 0.271430128538046 0.994570464429876 0.409090909090909 10.1 10 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.162896226121919 0.271430128538046 0.994570464429876 0.409090909090909 10.1 10 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.162896226121919 0.271430128538046 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.00543210999161518 0.0183607898291411 0.994570464429876 0.409090909090909 10.1 10 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 0.0534007368646435 0.112911216282894 0.992315202605772 0.408163265306122 10.1 10 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.133481952828477 0.236794598032349 0.990477581860206 0.407407407407407 10.1 10 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.133481952828477 0.236794598032349 0.990477581860206 0.407407407407407 10.1 10 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.110350544441233 0.20287961852697 0.987663725093557 0.40625 10.1 10 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 0.00486344728515659 0.0171304096207372 0.984524298122503 0.40495867768595 10.1 10 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.0170571466618862 0.0454537822094831 0.984045909250724 0.404761904761905 10.1 10 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.0170571466618862 0.0454537822094831 0.984045909250724 0.404761904761905 10.1 10 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0767947824992438 0.154189234346477 0.984045909250724 0.404761904761905 10.1 10 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00203975797924321 0.00861298398950469 0.975565933262426 0.401273885350318 10.1 10 1 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.164197440196587 0.272764407076393 0.972468898553656 0.4 10.1 10 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.202280596112676 0.319984670354879 0.972468898553656 0.4 10.1 10 1 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.00240540684045447 0.0097769350220002 0.972468898553656 0.4 10.1 10 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 0.0150426596592063 0.0408495283509839 0.972468898553656 0.4 10.1 10 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.11159926208689 0.204910645096316 0.972468898553656 0.4 10.1 10 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.134817331569617 0.236794598032349 0.972468898553656 0.4 10.1 10 1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.253578041702157 0.373082031105023 0.972468898553656 0.4 10.1 10 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0470590991229297 0.103341200697421 0.964750891422278 0.396825396825397 10.1 10 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0785049924978654 0.156241404649598 0.962339014193722 0.395833333333333 10.1 10 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0937121923053751 0.176159114465718 0.961161120663497 0.395348837209302 10.1 10 1 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.0937121923053751 0.176159114465718 0.961161120663497 0.395348837209302 10.1 10 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.135488023833393 0.236794598032349 0.957734521302843 0.393939393939394 10.1 10 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.135488023833393 0.236794598032349 0.957734521302843 0.393939393939394 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.164570038267253 0.272940751112239 0.955103382508055 0.392857142857143 10.1 10 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00407753230606056 0.0150319390453994 0.951328270324229 0.391304347826087 10.1 10 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.0941814881037501 0.176574779409271 0.951328270324229 0.391304347826087 10.1 10 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0941814881037501 0.176574779409271 0.951328270324229 0.391304347826087 10.1 10 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.201898804747494 0.319984670354879 0.951328270324229 0.391304347826087 10.1 10 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.00266273513620734 0.0107035934995001 0.946185955349504 0.389189189189189 10.1 10 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00480185510048689 0.0169554337667316 0.945455873593833 0.388888888888889 10.1 10 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.251313376914538 0.373082031105023 0.945455873593833 0.388888888888889 10.1 10 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.251313376914538 0.373082031105023 0.945455873593833 0.388888888888889 10.1 10 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.251313376914538 0.373082031105023 0.945455873593833 0.388888888888889 10.1 10 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.164272028717125 0.272764407076393 0.941098934084184 0.387096774193548 10.1 10 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.135411447478403 0.236794598032349 0.935066248609285 0.384615384615385 10.1 10 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.200658138977402 0.319984670354879 0.935066248609285 0.384615384615385 10.1 10 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.200658138977402 0.319984670354879 0.935066248609285 0.384615384615385 10.1 10 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.200658138977402 0.319984670354879 0.935066248609285 0.384615384615385 10.1 10 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.320187393601852 0.458376922631223 0.935066248609285 0.384615384615385 10.1 10 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.00086444661118402 0.00437760686019523 0.934332863316258 0.384313725490196 10.1 10 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.00658580288082895 0.0214944896775679 0.933925923915859 0.384146341463415 10.1 10 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.0076460654913053 0.0235505437102326 0.932713880688255 0.383647798742138 10.1 10 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.0076460654913053 0.0235505437102326 0.932713880688255 0.383647798742138 10.1 10 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.16348110783031 0.272086101102376 0.929565858911583 0.382352941176471 10.1 10 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.13486343603499 0.236794598032349 0.926160855765387 0.380952380952381 10.1 10 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.248071004061806 0.373082031105023 0.926160855765387 0.380952380952381 10.1 10 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.248071004061806 0.373082031105023 0.926160855765387 0.380952380952381 10.1 10 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.248071004061806 0.373082031105023 0.926160855765387 0.380952380952381 10.1 10 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.198839245290538 0.31971553225812 0.922168783111226 0.379310344827586 10.1 10 1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.133080611482529 0.236794598032349 0.911689592394053 0.375 10.1 10 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.244277212002757 0.369794119872258 0.911689592394053 0.375 10.1 10 1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.244277212002757 0.369794119872258 0.911689592394053 0.375 10.1 10 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.312285949843128 0.450235974292574 0.911689592394053 0.375 10.1 10 1 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.0406579986869512 0.0921279174068974 0.911689592394053 0.375 10.1 10 1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.00560073549440847 0.0188125413475291 0.907488257866891 0.373271889400922 10.1 10 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.13193648889597 0.236158017231402 0.905730836888209 0.372549019607843 10.1 10 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.240173542594417 0.364357090737586 0.90043416532746 0.37037037037037 10.1 10 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.240173542594417 0.364357090737586 0.90043416532746 0.37037037037037 10.1 10 1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.304417306053946 0.440229498490615 0.895695038141526 0.368421052631579 10.1 10 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.033082193804184 0.0773004298577237 0.893813325876522 0.367647058823529 10.1 10 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.155537793014956 0.261636321764464 0.893083682345195 0.36734693877551 10.1 10 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.235904563760546 0.364357090737586 0.891429823674185 0.366666666666667 10.1 10 1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0325628303435369 0.0768439595005855 0.890288428253347 0.366197183098592 10.1 10 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0376915145493808 0.0866478597799174 0.88728914101611 0.364963503649635 10.1 10 1 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0376915145493808 0.0866478597799174 0.88728914101611 0.364963503649635 10.1 10 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0373519771147736 0.086145645760653 0.885641318325651 0.364285714285714 10.1 10 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.231560288110811 0.359727390809699 0.884062635048779 0.363636363636364 10.1 10 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.231560288110811 0.359727390809699 0.884062635048779 0.363636363636364 10.1 10 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.231560288110811 0.359727390809699 0.884062635048779 0.363636363636364 10.1 10 1 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.123218926450552 0.222513365912609 0.880859509559471 0.36231884057971 10.1 10 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.182860128388488 0.301168938306503 0.879360174224051 0.361702127659574 10.1 10 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.147222471467269 0.255995402200601 0.876816220007395 0.360655737704918 10.1 10 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.0213219674591448 0.055266228951481 0.876209286767888 0.360406091370558 10.1 10 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.282175489442841 0.412678028239633 0.86827580228005 0.357142857142857 10.1 10 1 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.387877876900982 0.52717308388739 0.86827580228005 0.357142857142857 10.1 10 1 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.134283935033344 0.236794598032349 0.861681302515898 0.354430379746835 10.1 10 1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.0139229789979484 0.0381007675270781 0.85959304425725 0.353571428571429 10.1 10 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.268694386445631 0.393366370279972 0.858060792841461 0.352941176470588 10.1 10 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.268694386445631 0.393366370279972 0.858060792841461 0.352941176470588 10.1 10 1 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.37279513121746 0.507643513609996 0.858060792841461 0.352941176470588 10.1 10 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.159619637433723 0.267852292533241 0.856046565628219 0.352112676056338 10.1 10 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 8.72551160698496e-10 1.82594162010876e-08 0.853875130437357 0.351219512195122 10.1 10 1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.00651720569716061 0.0213195027748495 0.85216346780475 0.350515463917526 10.1 10 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.256222832641237 0.375881536957196 0.850910286234449 0.35 10.1 10 1 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.359413996022322 0.491775111865157 0.850910286234449 0.35 10.1 10 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.316514502142495 0.455870583551387 0.835715459694548 0.34375 10.1 10 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.117988641562382 0.213882594832191 0.827633105152048 0.340425531914894 10.1 10 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.309742171277142 0.447021409459811 0.810390748794714 0.333333333333333 10.1 10 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.384305957285757 0.522817760246302 0.810390748794714 0.333333333333333 10.1 10 1 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.433536008368922 0.579269239351152 0.810390748794714 0.333333333333333 10.1 10 1 LIGAND-GATED ION CHANNEL TRANSPORT%REACTOME%REACT_198558.2 LIGAND-GATED ION CHANNEL TRANSPORT 0.433536008368922 0.579269239351152 0.810390748794714 0.333333333333333 10.1 10 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.371102723983177 0.507280668806975 0.810390748794714 0.333333333333333 10.1 10 1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.455027794500394 0.595680360233727 0.810390748794714 0.333333333333333 10.1 10 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.455027794500394 0.595680360233727 0.810390748794714 0.333333333333333 10.1 10 1 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.455027794500394 0.595680360233727 0.810390748794714 0.333333333333333 10.1 10 1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.150308280428727 0.257688136471926 0.80541902640947 0.331288343558282 10.1 10 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.30851328353434 0.445699900984128 0.797105654552177 0.327868852459016 10.1 10 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.237736159841136 0.364357090737586 0.795243258163037 0.327102803738318 10.1 10 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.343956139127108 0.472898150703261 0.793852162084617 0.326530612244898 10.1 10 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.432683547316611 0.579217956567769 0.781448222052045 0.321428571428571 10.1 10 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.316910966261933 0.455980085936026 0.780376276617132 0.320987654320988 10.1 10 1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605493 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS) 0.390458820156169 0.530174523933424 0.775906036080045 0.319148936170213 10.1 10 1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.445528310755204 0.5947343210175 0.764082706006444 0.314285714285714 10.1 10 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.519910451162788 0.658800153165313 0.759741326995044 0.3125 10.1 10 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.519910451162788 0.658800153165313 0.759741326995044 0.3125 10.1 10 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.501116581453901 0.64011570503492 0.748052998887428 0.307692307692308 10.1 10 1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.353251694752968 0.485209615476326 0.745927848322407 0.306818181818182 10.1 10 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.48853297462426 0.636650874271288 0.742858186395154 0.305555555555556 10.1 10 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.524119039876352 0.662363582365941 0.739921988029956 0.304347826086957 10.1 10 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.524119039876352 0.662363582365941 0.739921988029956 0.304347826086957 10.1 10 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.524119039876352 0.662363582365941 0.739921988029956 0.304347826086957 10.1 10 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.550435795406461 0.692546540109101 0.729351673915242 0.3 10.1 10 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.550435795406461 0.692546540109101 0.729351673915242 0.3 10.1 10 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.527634035221568 0.665623432730755 0.729351673915242 0.3 10.1 10 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.525047665865416 0.662948383785703 0.712161567122627 0.292929292929293 10.1 10 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.575700551952119 0.717985876799181 0.709091905195374 0.291666666666667 10.1 10 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 0.544896429638992 0.686791514062255 0.707809641352345 0.291139240506329 10.1 10 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.624431640253394 0.771994981825004 0.68072822898756 0.28 10.1 10 1 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.624431640253394 0.771994981825004 0.68072822898756 0.28 10.1 10 1 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.654924768459403 0.784476385115934 0.663046976286584 0.272727272727273 10.1 10 1 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.654924768459403 0.784476385115934 0.663046976286584 0.272727272727273 10.1 10 1 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.654924768459403 0.784476385115934 0.663046976286584 0.272727272727273 10.1 10 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.657275407042687 0.786629860573375 0.663046976286584 0.272727272727273 10.1 10 1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 0.969130178621156 1 0.651170400165022 0.26784214945424 10.1 10 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.695562055671306 0.826197667128772 0.643545594631096 0.264705882352941 10.1 10 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.689747170227503 0.819975123837708 0.63978217010109 0.263157894736842 10.1 10 1 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.706848294700928 0.838204269466183 0.63978217010109 0.263157894736842 10.1 10 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.717319818900171 0.849913490670228 0.636735588338704 0.261904761904762 10.1 10 1 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.701091496194597 0.832071058452803 0.634218846882819 0.260869565217391 10.1 10 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.731036016941471 0.857596250707101 0.625158577641636 0.257142857142857 10.1 10 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.739869325808957 0.865328356523313 0.623377499072857 0.256410256410256 10.1 10 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.749832111535288 0.86678399245712 0.607793061596035 0.25 10.1 10 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.846679674302212 0.947189604191861 0.600642554989023 0.247058823529412 10.1 10 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.846679674302212 0.947189604191861 0.600642554989023 0.247058823529412 10.1 10 1 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 0.99966587768238 1 0.600099478537858 0.246835443037975 10.1 10 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.813425618704464 0.929751741756117 0.561039749165571 0.230769230769231 10.1 10 1 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.842802408584156 0.944336871980515 0.555696513459232 0.228571428571429 10.1 10 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.842114972762245 0.944336871980515 0.548974378215774 0.225806451612903 10.1 10 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.842114972762245 0.944336871980515 0.548974378215774 0.225806451612903 10.1 10 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.842114972762245 0.944336871980515 0.548974378215774 0.225806451612903 10.1 10 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.982061515750092 1 0.548974378215774 0.225806451612903 10.1 10 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.842487015570167 0.944336871980515 0.540260499196476 0.222222222222222 10.1 10 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.866008656590267 0.967669222103015 0.531818928896531 0.21875 10.1 10 1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.927310566530002 1 0.506494217996696 0.208333333333333 10.1 10 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.893943373791513 0.983821671233816 0.486234449276828 0.2 10.1 10 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.998011187309626 1 0.427706228530543 0.175925925925926 10.1 10 1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.970030342980816 1 0.39212455586841 0.161290322580645 10.1 10 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.999666382737681 1 0.351169324477709 0.144444444444444 10.1 10 1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.309778399136044 0.12741935483871 10.1 10 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 8.9438528142081e-06 4.8208721797796e-05 1.63385093167702 1 11.2 11 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 8.9438528142081e-06 4.8208721797796e-05 1.63385093167702 1 11.2 11 2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 8.9438528142081e-06 4.8208721797796e-05 1.63385093167702 1 11.2 11 2 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 2.35692657151479e-05 0.000119356103603756 1.63385093167702 1 11.2 11 2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 6.21078537267698e-05 0.000288821816513704 1.63385093167702 1 11.2 11 2 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 6.21078537267698e-05 0.000288821816513704 1.63385093167702 1 11.2 11 2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.000163653784410178 0.000684939221222598 1.63385093167702 1 11.2 11 2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.000163653784410178 0.000684939221222598 1.63385093167702 1 11.2 11 2 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.000163653784410178 0.000684939221222598 1.63385093167702 1 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.000431205853950869 0.00156932462959613 1.63385093167702 1 11.2 11 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00113611504299321 0.0036167599690813 1.63385093167702 1 11.2 11 2 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 COENZYME A BIOSYNTHESIS%REACTOME%REACT_216415.1 COENZYME A BIOSYNTHESIS 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0029932227767783 0.0083845590774715 1.63385093167702 1 11.2 11 2 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%REACT_202113.1 SYNTHESIS OF DOLICHYL-PHOSPHATE 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%REACT_196604.2 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 ABACAVIR METABOLISM%REACTOME%REACT_196553.2 ABACAVIR METABOLISM 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604759 KETONE BODY METABOLISM 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604894 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604895 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%REACT_198544.2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5604893 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA 0.00788560181479947 0.0184559397737823 1.63385093167702 1 11.2 11 2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 3.39376910867037e-06 2.0291316981672e-05 1.63385093167702 1 11.2 11 2 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.04362045282365e-08 1.67130569216555e-07 1.55958498023715 0.954545454545455 11.2 11 2 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 2.02603463130742e-06 1.27568463732321e-05 1.53774205334308 0.941176470588235 11.2 11 2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 5.0367765394477e-06 2.82178465182444e-05 1.5317352484472 0.9375 11.2 11 2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 5.0367765394477e-06 2.82178465182444e-05 1.5317352484472 0.9375 11.2 11 2 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 5.0367765394477e-06 2.82178465182444e-05 1.5317352484472 0.9375 11.2 11 2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 3.07725017499129e-05 0.000152575853624133 1.51714729370009 0.928571428571429 11.2 11 2 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 3.07725017499129e-05 0.000152575853624133 1.51714729370009 0.928571428571429 11.2 11 2 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.000184448807625487 0.000752064909028846 1.4976966873706 0.916666666666667 11.2 11 2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.000184448807625487 0.000752064909028846 1.4976966873706 0.916666666666667 11.2 11 2 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.000184448807625487 0.000752064909028846 1.4976966873706 0.916666666666667 11.2 11 2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 1.50026884147028e-07 1.07822351586475e-06 1.49177693761815 0.91304347826087 11.2 11 2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000447493733842988 0.00162444791647595 1.48531902879729 0.909090909090909 11.2 11 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 2.08203107267691e-06 1.30516749621993e-05 1.47046583850932 0.9 11.2 11 2 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.00107756716056085 0.00354948627194002 1.47046583850932 0.9 11.2 11 2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 5.98511792148866e-08 4.65400153129966e-07 1.45231193926846 0.888888888888889 11.2 11 2 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0025716224102764 0.00730422892180303 1.45231193926846 0.888888888888889 11.2 11 2 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 2.76173408504998e-05 0.000139359844078941 1.44163317500913 0.882352941176471 11.2 11 2 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 3.29264821421841e-07 2.24183655925014e-06 1.43778881987578 0.88 11.2 11 2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 7.66699773367486e-07 4.98179807078508e-06 1.42961956521739 0.875 11.2 11 2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 7.66699773367486e-07 4.98179807078508e-06 1.42961956521739 0.875 11.2 11 2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 6.45472517966495e-05 0.000297251583516609 1.42961956521739 0.875 11.2 11 2 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 6.45472517966495e-05 0.000297251583516609 1.42961956521739 0.875 11.2 11 2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00607047936628962 0.0152890126340356 1.42961956521739 0.875 11.2 11 2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 1.7756744438253e-06 1.12301543713929e-05 1.42073994058871 0.869565217391304 11.2 11 2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.000149702454471459 0.000642305133840642 1.41600414078675 0.866666666666667 11.2 11 2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 3.43406727984611e-09 3.11253359186052e-08 1.40692719116632 0.861111111111111 11.2 11 2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 2.66854889493427e-07 1.84337139684052e-06 1.40044365572316 0.857142857142857 11.2 11 2 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 9.35301010568427e-06 5.02238995486367e-05 1.40044365572316 0.857142857142857 11.2 11 2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 INACTIVATION OF CDC42 AND RAC%REACTOME DATABASE ID RELEASE 48%5605516 INACTIVATION OF CDC42 AND RAC 0.0141358691794888 0.0297564228438056 1.40044365572316 0.857142857142857 11.2 11 2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 2.12467106291632e-05 0.000109543729077171 1.38877329192547 0.85 11.2 11 2 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 1.36634851988437e-06 8.6799729633726e-06 1.38248924988055 0.846153846153846 11.2 11 2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.000783420534522029 0.00264799862381199 1.38248924988055 0.846153846153846 11.2 11 2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.000783420534522029 0.00264799862381199 1.38248924988055 0.846153846153846 11.2 11 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.24432807566407e-11 2.21334856458746e-10 1.37756058945317 0.843137254901961 11.2 11 2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 1.24432807566407e-11 2.21334856458746e-10 1.37756058945317 0.843137254901961 11.2 11 2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 6.17049212774402e-11 7.83983062301762e-10 1.36709975915832 0.836734693877551 11.2 11 2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 3.08163496227188e-15 7.97303009329616e-14 1.36154244306418 0.833333333333333 11.2 11 2 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.000107024582049109 0.000478918176905289 1.36154244306418 0.833333333333333 11.2 11 2 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.000107024582049109 0.000478918176905289 1.36154244306418 0.833333333333333 11.2 11 2 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0017627183649305 0.00528073312272862 1.36154244306418 0.833333333333333 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_196638.2 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 TRANSPORT AND SYNTHESIS OF PAPS%REACTOME%REACT_214239.1 TRANSPORT AND SYNTHESIS OF PAPS 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%REACT_198606.2 ER QUALITY CONTROL COMPARTMENT (ERQC) 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK%REACTOME%REACT_215503.1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKK 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%REACT_198541.2 MOLYBDENUM COFACTOR BIOSYNTHESIS 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 ACYL CHAIN REMODELING OF CL%REACTOME%REACT_199034.2 ACYL CHAIN REMODELING OF CL 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%REACT_196492.2 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.0323474970049053 0.0603261717257041 1.36154244306418 0.833333333333333 11.2 11 2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 4.46724834665944e-07 3.0127461598561e-06 1.36154244306418 0.833333333333333 11.2 11 2 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 1.50737268126888e-05 7.82843549432706e-05 1.34970294355928 0.826086956521739 11.2 11 2 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 5.46811868825003e-31 1.11159041333997e-28 1.34792701863354 0.825 11.2 11 2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.000236886836212014 0.000941592089189095 1.34552429667519 0.823529411764706 11.2 11 2 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000236886836212014 0.000941592089189095 1.34552429667519 0.823529411764706 11.2 11 2 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.000236886836212014 0.000941592089189095 1.34552429667519 0.823529411764706 11.2 11 2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 3.15199129402776e-09 2.93155791594869e-08 1.33678712591756 0.818181818181818 11.2 11 2 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 3.15199129402776e-09 2.93155791594869e-08 1.33678712591756 0.818181818181818 11.2 11 2 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 3.30438491649393e-05 0.000162142749523133 1.33678712591756 0.818181818181818 11.2 11 2 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00391289758079123 0.0105057608631432 1.33678712591756 0.818181818181818 11.2 11 2 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 4.61971600509774e-08 3.61200872266708e-07 1.33287839163125 0.815789473684211 11.2 11 2 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 4.7136036169812e-06 2.69375821163223e-05 1.33128594432942 0.814814814814815 11.2 11 2 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.000518708332728972 0.00181356746307943 1.32750388198758 0.8125 11.2 11 2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 9.98542178253018e-08 7.59853219066334e-07 1.32474399865704 0.810810810810811 11.2 11 2 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.41134906894481e-12 6.55993206095739e-11 1.32264123040521 0.80952380952381 11.2 11 2 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 1.01901492261126e-05 5.43092971863604e-05 1.31964882943144 0.807692307692308 11.2 11 2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 1.01901492261126e-05 5.43092971863604e-05 1.31964882943144 0.807692307692308 11.2 11 2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 2.14575128184484e-07 1.49676670297314e-06 1.31615769496204 0.805555555555556 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 3.15817559755042e-08 2.51066138285712e-07 1.31505074988638 0.804878048780488 11.2 11 2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 3.15817559755042e-08 2.51066138285712e-07 1.31505074988638 0.804878048780488 11.2 11 2 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 4.67824062850837e-09 4.13486733811641e-08 1.31418444504456 0.804347826086957 11.2 11 2 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 9.96887949189439e-09 8.54561175720826e-08 1.30708074534161 0.8 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.000154470209993989 0.000654199728635259 1.30708074534161 0.8 11.2 11 2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.000154470209993989 0.000654199728635259 1.30708074534161 0.8 11.2 11 2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605618 CALCITONIN-LIKE LIGAND RECEPTORS 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.00854784340913862 0.019618679308394 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 3.32058271957438e-11 5.19251561533444e-10 1.30708074534161 0.8 11.2 11 2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 3.14514551827035e-06 1.88841437658173e-05 1.30708074534161 0.8 11.2 11 2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 2.18498058962436e-05 0.000111043834965552 1.30708074534161 0.8 11.2 11 2 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 2.18498058962436e-05 0.000111043834965552 1.30708074534161 0.8 11.2 11 2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 2.18498058962436e-05 0.000111043834965552 1.30708074534161 0.8 11.2 11 2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.0011220851344399 0.0036167599690813 1.30708074534161 0.8 11.2 11 2 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0011220851344399 0.0036167599690813 1.30708074534161 0.8 11.2 11 2 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0011220851344399 0.0036167599690813 1.30708074534161 0.8 11.2 11 2 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 1.42847477701345e-07 1.03710184065823e-06 1.29870202261507 0.794871794871795 11.2 11 2 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 6.6775013923728e-06 3.66875848700637e-05 1.29581280788177 0.793103448275862 11.2 11 2 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 6.62783127034808e-09 5.82185425784279e-08 1.29346532091097 0.791666666666667 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 4.64358070756714e-05 0.000223237004961758 1.29346532091097 0.791666666666667 11.2 11 2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.000328773975350286 0.00122794059559962 1.28988231448186 0.789473684210526 11.2 11 2 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 1.07403707198308e-13 2.35131500527989e-12 1.28665760869565 0.7875 11.2 11 2 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.39049848749844e-08 1.17778532601802e-07 1.2862230738734 0.787234042553192 11.2 11 2 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 6.52135147229233e-10 7.19370786439689e-09 1.28374001774623 0.785714285714286 11.2 11 2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 1.40626035268609e-05 7.33006769916596e-05 1.28374001774623 0.785714285714286 11.2 11 2 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.00239397286273059 0.00692403126761306 1.28374001774623 0.785714285714286 11.2 11 2 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.00239397286273059 0.00692403126761306 1.28374001774623 0.785714285714286 11.2 11 2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 4.28376132787051e-06 2.45798079417731e-05 1.27644604037267 0.78125 11.2 11 2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 2.93580588580725e-05 0.000146584272824692 1.2707729468599 0.777777777777778 11.2 11 2 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 2.93580588580725e-05 0.000146584272824692 1.2707729468599 0.777777777777778 11.2 11 2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 6.02039588682703e-08 4.65599094943199e-07 1.2707729468599 0.777777777777778 11.2 11 2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 1.3111185075934e-06 8.36646473679553e-06 1.2707729468599 0.777777777777778 11.2 11 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.000691404725782181 0.00237076849346517 1.2707729468599 0.777777777777778 11.2 11 2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.000691404725782181 0.00237076849346517 1.2707729468599 0.777777777777778 11.2 11 2 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0183164787123359 0.0377197528330738 1.2707729468599 0.777777777777778 11.2 11 2 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0183164787123359 0.0377197528330738 1.2707729468599 0.777777777777778 11.2 11 2 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0183164787123359 0.0377197528330738 1.2707729468599 0.777777777777778 11.2 11 2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.99046390273639e-12 3.98933821632942e-11 1.26838427590716 0.776315789473684 11.2 11 2 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 8.77370647713565e-10 9.11312723865987e-09 1.26764296423217 0.775862068965517 11.2 11 2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 8.77370647713565e-10 9.11312723865987e-09 1.26764296423217 0.775862068965517 11.2 11 2 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 4.02852092006696e-07 2.72980250916919e-06 1.26623447204969 0.775 11.2 11 2 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 1.24179884078183e-07 9.10865850738426e-07 1.2625211744777 0.772727272727273 11.2 11 2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00020354863939658 0.000820537433034937 1.2625211744777 0.772727272727273 11.2 11 2 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00020354863939658 0.000820537433034937 1.2625211744777 0.772727272727273 11.2 11 2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.00020354863939658 0.000820537433034937 1.2625211744777 0.772727272727273 11.2 11 2 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 2.7069725296092e-06 1.63221267357368e-05 1.26039929015084 0.771428571428571 11.2 11 2 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 2.7069725296092e-06 1.63221267357368e-05 1.26039929015084 0.771428571428571 11.2 11 2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.7069725296092e-06 1.63221267357368e-05 1.26039929015084 0.771428571428571 11.2 11 2 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 6.07153281300142e-05 0.000284203657661218 1.25680840898232 0.769230769230769 11.2 11 2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00502704446629208 0.0130538034225066 1.25680840898232 0.769230769230769 11.2 11 2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.00502704446629208 0.0130538034225066 1.25680840898232 0.769230769230769 11.2 11 2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 5.47506885565395e-11 7.20636983972738e-10 1.25498694752003 0.768115942028985 11.2 11 2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 2.42535355481275e-08 1.96095347073781e-07 1.24941541834125 0.764705882352941 11.2 11 2 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.00143462819640908 0.00441877905517343 1.24941541834125 0.764705882352941 11.2 11 2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.00143462819640908 0.00441877905517343 1.24941541834125 0.764705882352941 11.2 11 2 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.00143462819640908 0.00441877905517343 1.24941541834125 0.764705882352941 11.2 11 2 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 2.33241474266511e-09 2.24258525595436e-08 1.24615749026213 0.76271186440678 11.2 11 2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 2.33241474266511e-09 2.24258525595436e-08 1.24615749026213 0.76271186440678 11.2 11 2 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.000419031080842119 0.0015447700208247 1.24483880508725 0.761904761904762 11.2 11 2 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000419031080842119 0.0015447700208247 1.24483880508725 0.761904761904762 11.2 11 2 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 2.25836826355061e-10 2.57092643122601e-09 1.24367757485863 0.761194029850746 11.2 11 2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.04143241717975e-11 8.86721976074937e-10 1.24264718747266 0.76056338028169 11.2 11 2 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 1.46472675754987e-09 1.44743484443991e-08 1.23856441594871 0.758064516129032 11.2 11 2 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 1.12692595949191e-05 5.93931718650738e-05 1.23776585733107 0.757575757575758 11.2 11 2 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 2.86666569140564e-25 3.39938773239185e-23 1.23426782338644 0.755434782608696 11.2 11 2 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 9.9173736888502e-08 7.58732406410421e-07 1.23372417289897 0.755102040816326 11.2 11 2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.70563924964868e-12 5.27414335924667e-11 1.23019364267446 0.752941176470588 11.2 11 2 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 2.10532588559832e-06 1.31398190140632e-05 1.22538819875776 0.75 11.2 11 2 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000251637737305151 0.000994350265707038 1.22538819875776 0.75 11.2 11 2 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 0.000251637737305151 0.000994350265707038 1.22538819875776 0.75 11.2 11 2 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.000851685271419176 0.00284494868833213 1.22538819875776 0.75 11.2 11 2 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.000851685271419176 0.00284494868833213 1.22538819875776 0.75 11.2 11 2 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0029322155395727 0.00827885458891262 1.22538819875776 0.75 11.2 11 2 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.0029322155395727 0.00827885458891262 1.22538819875776 0.75 11.2 11 2 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.0103634352283734 0.0233341271043914 1.22538819875776 0.75 11.2 11 2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0383320386190864 0.0698418578168501 1.22538819875776 0.75 11.2 11 2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 9.61923460005037e-19 7.60453935326204e-17 1.2224496179454 0.748201438848921 11.2 11 2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 1.09955422485124e-10 1.29311211732505e-09 1.21994202898551 0.746666666666667 11.2 11 2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 1.13149676750658e-09 1.14192900720699e-08 1.21929174005748 0.746268656716418 11.2 11 2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 1.13149676750658e-09 1.14192900720699e-08 1.21929174005748 0.746268656716418 11.2 11 2 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.3110463025583e-11 2.24773360065116e-10 1.21097186700767 0.741176470588235 11.2 11 2 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.3110463025583e-11 2.24773360065116e-10 1.21097186700767 0.741176470588235 11.2 11 2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.3110463025583e-11 2.24773360065116e-10 1.21097186700767 0.741176470588235 11.2 11 2 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.000150307526049848 0.000642305133840642 1.21025994939038 0.740740740740741 11.2 11 2 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00170677082699148 0.00521187743950404 1.20389016018307 0.736842105263158 11.2 11 2 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.69389413671901e-09 2.53868301758355e-08 1.20136097917428 0.735294117647059 11.2 11 2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.00589166411552997 0.0152433418843621 1.19815734989648 0.733333333333333 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 4.98760610697444e-06 2.82178465182444e-05 1.19550068171489 0.731707317073171 11.2 11 2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 4.98760610697444e-06 2.82178465182444e-05 1.19550068171489 0.731707317073171 11.2 11 2 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 5.91195850729055e-12 1.10693644156243e-10 1.1946436919789 0.731182795698925 11.2 11 2 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 2.86936357791155e-07 1.96303094777314e-06 1.19396798853321 0.730769230769231 11.2 11 2 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 2.86936357791155e-07 1.96303094777314e-06 1.19396798853321 0.730769230769231 11.2 11 2 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.000296855311419533 0.00111309839810527 1.19396798853321 0.730769230769231 11.2 11 2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 5.98518082171779e-11 7.67289397234631e-10 1.19175009134088 0.729411764705882 11.2 11 2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 2.18358478580544e-13 4.63767335850917e-12 1.19103152028792 0.728971962616822 11.2 11 2 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.90547265963739e-10 2.18668354408387e-09 1.19008895023388 0.728395061728395 11.2 11 2 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.90547265963739e-10 2.18668354408387e-09 1.19008895023388 0.728395061728395 11.2 11 2 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 8.09269082964231e-15 1.95184729670865e-13 1.18825522303783 0.727272727272727 11.2 11 2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.000993650924696891 0.00330365716318616 1.18825522303783 0.727272727272727 11.2 11 2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0209076989513983 0.0416107071438318 1.18825522303783 0.727272727272727 11.2 11 2 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.93285662929198e-15 1.2534741041933e-13 1.18585954718493 0.725806451612903 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000174919613219901 0.000719394825467975 1.18313343328336 0.724137931034483 11.2 11 2 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.54257699354804e-24 3.60077647272776e-22 1.18259686483289 0.723809523809524 11.2 11 2 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00336700922003902 0.00928537620177426 1.18000345065562 0.722222222222222 11.2 11 2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7.07764859018452e-10 7.51604025659147e-09 1.17885446969101 0.721518987341772 11.2 11 2 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 1.34861521702229e-10 1.57301594575632e-09 1.17789253213925 0.720930232558139 11.2 11 2 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 5.78817395547172e-06 3.21741075727979e-05 1.17789253213925 0.720930232558139 11.2 11 2 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 5.78817395547172e-06 3.21741075727979e-05 1.17789253213925 0.720930232558139 11.2 11 2 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.00057909954829133 0.00201481334283267 1.17637267080745 0.72 11.2 11 2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.00057909954829133 0.00201481334283267 1.17637267080745 0.72 11.2 11 2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.35461853454299e-09 1.34798753472355e-08 1.17302118171683 0.717948717948718 11.2 11 2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 3.44913785612679e-06 2.03656563040183e-05 1.17211045098569 0.717391304347826 11.2 11 2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 3.44913785612679e-06 2.03656563040183e-05 1.17211045098569 0.717391304347826 11.2 11 2 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 3.44913785612679e-06 2.03656563040183e-05 1.17211045098569 0.717391304347826 11.2 11 2 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 9.40927502332443e-12 1.71658953310137e-10 1.17175167827342 0.717171717171717 11.2 11 2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 6.41766793666891e-07 4.20845229211053e-06 1.17144029063635 0.716981132075472 11.2 11 2 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 7.71336645473159e-15 1.89243456294535e-13 1.16883182035356 0.715384615384615 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0003379652790452 0.00125896490073644 1.1670363797693 0.714285714285714 11.2 11 2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00193332074786182 0.00570770834897795 1.1670363797693 0.714285714285714 11.2 11 2 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00193332074786182 0.00570770834897795 1.1670363797693 0.714285714285714 11.2 11 2 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0116097234751958 0.0256986608769495 1.1670363797693 0.714285714285714 11.2 11 2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604713 CREATINE METABOLISM 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 48%5605578 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%REACT_196649.2 SUMO IS PROTEOLYTICALLY PROCESSED 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_13686.1 LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605627 CATION-COUPLED CHLORIDE COTRANSPORTERS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%REACT_222486.1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%REACT_196618.2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605499 NEUROFASCIN INTERACTIONS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0778765665684466 0.122809222962084 1.1670363797693 0.714285714285714 11.2 11 2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 8.15978931130456e-09 7.12354612882601e-08 1.16383901982473 0.712328767123288 11.2 11 2 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 2.29392534860636e-17 1.25548298887186e-15 1.16116449861323 0.710691823899371 11.2 11 2 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 2.66681143950304e-18 1.72494212655129e-16 1.1601308390606 0.710059171597633 11.2 11 2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.001114652227893 0.0036167599690813 1.15731107660455 0.708333333333333 11.2 11 2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.001114652227893 0.0036167599690813 1.15731107660455 0.708333333333333 11.2 11 2 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.001114652227893 0.0036167599690813 1.15731107660455 0.708333333333333 11.2 11 2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.75420051216327e-09 1.72153608883333e-08 1.15565065899106 0.707317073170732 11.2 11 2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 8.12819078974578e-17 3.85547183126942e-15 1.15514301538948 0.707006369426752 11.2 11 2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 9.22192593369054e-09 7.95321248705554e-08 1.15458799171843 0.706666666666667 11.2 11 2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 4.41610762706266e-12 8.37882820441355e-11 1.15418827283606 0.706422018348624 11.2 11 2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 5.67685747225353e-18 3.51224703609425e-16 1.15330654000731 0.705882352941177 11.2 11 2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.000115610385913495 0.000515716549074934 1.15330654000731 0.705882352941177 11.2 11 2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0065264251631654 0.0163505334633528 1.15330654000731 0.705882352941177 11.2 11 2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0065264251631654 0.0163505334633528 1.15330654000731 0.705882352941177 11.2 11 2 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 0.000644906301672542 0.0022274312312622 1.14974695192087 0.703703703703704 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.000644906301672542 0.0022274312312622 1.14974695192087 0.703703703703704 11.2 11 2 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 3.29256323789606e-09 3.04241395293902e-08 1.14974695192086 0.703703703703704 11.2 11 2 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.71828003351244e-13 1.17929166488235e-11 1.14774652225245 0.702479338842975 11.2 11 2 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.71828003351244e-13 1.17929166488235e-11 1.14774652225245 0.702479338842975 11.2 11 2 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 2.8110377807425e-27 4.44456306888509e-25 1.14729973511144 0.702205882352941 11.2 11 2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 9.24075089451543e-12 1.7077387692072e-10 1.14369565217391 0.7 11.2 11 2 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.00370197045666021 0.0101501039688391 1.14369565217391 0.7 11.2 11 2 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.00370197045666021 0.0101501039688391 1.14369565217391 0.7 11.2 11 2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00370197045666021 0.0101501039688391 1.14369565217391 0.7 11.2 11 2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0411099610864629 0.0741438208188044 1.14369565217391 0.7 11.2 11 2 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.14657570185843e-16 5.09867882420172e-15 1.14269328963914 0.699386503067485 11.2 11 2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 3.22741030388806e-08 2.55144714579595e-07 1.14145750021271 0.698630136986301 11.2 11 2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 2.18552528435117e-09 2.13013868467926e-08 1.13989599884443 0.697674418604651 11.2 11 2 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 1.83401098746479e-15 7.90847768231031e-14 1.13939604445897 0.697368421052632 11.2 11 2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.000217746120862067 0.00087282459151189 1.13874458874459 0.696969696969697 11.2 11 2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.000217746120862067 0.00087282459151189 1.13874458874459 0.696969696969697 11.2 11 2 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 1.3028539661674e-09 1.30560647454662e-08 1.13818828948287 0.696629213483146 11.2 11 2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00211433807358136 0.00620351150248717 1.13659195247097 0.695652173913043 11.2 11 2 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.00211433807358136 0.00620351150248717 1.13659195247097 0.695652173913043 11.2 11 2 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00211433807358136 0.00620351150248717 1.13659195247097 0.695652173913043 11.2 11 2 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 4.62978715025386e-10 5.14702118344629e-09 1.13509643674403 0.694736842105263 11.2 11 2 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.000126975464183106 0.000559399645611639 1.13461870255349 0.694444444444444 11.2 11 2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 4.04700073049816e-09 3.5993012746868e-08 1.13408476434052 0.694117647058824 11.2 11 2 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 4.04700073049816e-09 3.5993012746868e-08 1.13408476434052 0.694117647058824 11.2 11 2 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 7.41899550099447e-05 0.000340555825739198 1.13112756808409 0.692307692307692 11.2 11 2 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 9.80770770037028e-11 1.21359722240234e-09 1.13112756808409 0.692307692307692 11.2 11 2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.00121414908125287 0.00383940920582851 1.13112756808409 0.692307692307692 11.2 11 2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00121414908125287 0.00383940920582851 1.13112756808409 0.692307692307692 11.2 11 2 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.00121414908125287 0.00383940920582851 1.13112756808409 0.692307692307692 11.2 11 2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0223703144430564 0.0440668576829492 1.13112756808409 0.692307692307692 11.2 11 2 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.40177752711558e-12 4.74684641817427e-11 1.12908397717518 0.691056910569106 11.2 11 2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 9.91451143217208e-14 2.20442965124701e-12 1.1284150319496 0.690647482014389 11.2 11 2 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.16881033630352e-17 1.23448684342396e-15 1.12494654312188 0.688524590163934 11.2 11 2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.16881033630352e-17 1.23448684342396e-15 1.12494654312188 0.688524590163934 11.2 11 2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 5.78930091671801e-07 3.81397000207858e-06 1.12327251552795 0.6875 11.2 11 2 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.012402450982636 0.0271101194290184 1.12327251552795 0.6875 11.2 11 2 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 1.97755654438528e-13 4.26373176160645e-12 1.12035492457853 0.685714285714286 11.2 11 2 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000137022357358371 0.00059994712160296 1.11789800588428 0.684210526315789 11.2 11 2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.000137022357358371 0.00059994712160296 1.11789800588428 0.684210526315789 11.2 11 2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.00696419240497533 0.0173252548816082 1.11789800588428 0.684210526315789 11.2 11 2 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 5.49486020380611e-26 7.81918607001609e-24 1.11525660865326 0.68259385665529 11.2 11 2 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 1.47821307145762e-08 1.2158943356556e-07 1.11486298867373 0.682352941176471 11.2 11 2 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 3.19811825317204e-23 2.84432642141488e-21 1.11427381547322 0.681992337164751 11.2 11 2 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 2.18197880829612e-07 1.51461260692945e-06 1.11192632850242 0.680555555555556 11.2 11 2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.08833345042324e-09 1.11417158269948e-08 1.11101863354037 0.68 11.2 11 2 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.00225270167204653 0.00656884114615208 1.11101863354037 0.68 11.2 11 2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 4.5223346316597e-08 3.5554045198076e-07 1.10940495360785 0.679012345679012 11.2 11 2 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 7.01670811859822e-13 1.42639652182361e-11 1.10868456078083 0.678571428571429 11.2 11 2 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00129289290499693 0.00406133908125966 1.10868456078083 0.678571428571429 11.2 11 2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.000745365573958903 0.00254965195130654 1.10680224403927 0.67741935483871 11.2 11 2 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.25332422327995e-35 3.56696073945475e-33 1.10457527775348 0.676056338028169 11.2 11 2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 3.34520209049867e-14 7.67777834641872e-13 1.10284937888199 0.675 11.2 11 2 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 8.49827066232294e-05 0.000388843702652268 1.10189946554962 0.674418604651163 11.2 11 2 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 1.00390992414716e-08 8.55427438360127e-08 1.10107345395625 0.673913043478261 11.2 11 2 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 4.9667299045401e-05 0.000237169686381227 1.10107345395625 0.673913043478261 11.2 11 2 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 3.52994058717251e-09 3.1791806680674e-08 1.10034858663962 0.673469387755102 11.2 11 2 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 6.97677751131001e-22 5.83997317564362e-20 1.09970735785953 0.673076923076923 11.2 11 2 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 1.05353636250067e-18 7.89043286230763e-17 1.09913608130999 0.672727272727273 11.2 11 2 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 1.46331185834234e-07 1.05700140833561e-06 1.09612784023901 0.670886075949367 11.2 11 2 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 3.03332702861528e-08 2.43865783147996e-07 1.095422783738 0.670454545454545 11.2 11 2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.43723003790903e-11 5.25933155262854e-10 1.09352227710667 0.669291338582677 11.2 11 2 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 2.11272626159046e-18 1.50320473512161e-16 1.09167618304877 0.668161434977579 11.2 11 2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 8.94202457735453e-15 2.12075016226258e-13 1.08923395445135 0.666666666666667 11.2 11 2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.64673290952627e-06 2.14433922737846e-05 1.08923395445135 0.666666666666667 11.2 11 2 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0128452570494182 0.0277371787273476 1.08923395445135 0.666666666666667 11.2 11 2 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.0419962263974481 0.0745145014508337 1.08923395445135 0.666666666666667 11.2 11 2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.0419962263974481 0.0745145014508337 1.08923395445135 0.666666666666667 11.2 11 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0783631584325874 0.122809222962084 1.08923395445135 0.666666666666667 11.2 11 2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.62890556371977e-11 5.49354533741833e-10 1.08923395445135 0.666666666666667 11.2 11 2 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 1.02744556095549e-10 1.2603922700342e-09 1.08923395445135 0.666666666666667 11.2 11 2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.00723926987425702 0.0178753726889109 1.08923395445135 0.666666666666667 11.2 11 2 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.00723926987425702 0.0178753726889109 1.08923395445135 0.666666666666667 11.2 11 2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00723926987425702 0.0178753726889109 1.08923395445135 0.666666666666667 11.2 11 2 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.0230458421945274 0.0445050739185603 1.08923395445135 0.666666666666667 11.2 11 2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.18864463953412e-15 7.97303009329616e-14 1.08072431418219 0.661458333333333 11.2 11 2 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.57507669920926e-09 2.44288942864986e-08 1.07924098239216 0.660550458715596 11.2 11 2 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 3.51916528278493e-39 1.25194304935074e-36 1.07784462603028 0.659695817490494 11.2 11 2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 9.28768321105264e-05 0.00042224834534594 1.07764635919123 0.659574468085106 11.2 11 2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000272498835615291 0.00106822546303184 1.0759506135434 0.658536585365854 11.2 11 2 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.000272498835615291 0.00106822546303184 1.0759506135434 0.658536585365854 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 3.95858899767941e-06 2.30863612446631e-05 1.07297673125058 0.656716417910448 11.2 11 2 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 3.95858899767941e-06 2.30863612446631e-05 1.07297673125058 0.656716417910448 11.2 11 2 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.16068616288402e-08 1.75694651987655e-07 1.07273040968693 0.656565656565657 11.2 11 2 DISEASE%REACTOME%REACT_189085.2 DISEASE 4.31409597206308e-56 3.06947928412288e-53 1.07110329963974 0.655569782330346 11.2 11 2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 9.83241733977739e-10 1.01387897641328e-08 1.07092750143536 0.65546218487395 11.2 11 2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 1.74927500285946e-07 1.2446091645345e-06 1.07045405868494 0.655172413793103 11.2 11 2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 1.74927500285946e-07 1.2446091645345e-06 1.07045405868494 0.655172413793103 11.2 11 2 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 5.61438736758321e-05 0.000265424359603685 1.06828714763497 0.653846153846154 11.2 11 2 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00421441212132347 0.0111057563863765 1.06828714763497 0.653846153846154 11.2 11 2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00421441212132347 0.0111057563863765 1.06828714763497 0.653846153846154 11.2 11 2 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00421441212132347 0.0111057563863765 1.06828714763497 0.653846153846154 11.2 11 2 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 3.60094250378361e-10 4.06677871657466e-09 1.06779234117474 0.653543307086614 11.2 11 2 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.41298640190348e-06 1.48644140688686e-05 1.06654158040028 0.652777777777778 11.2 11 2 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 2.41298640190348e-06 1.48644140688686e-05 1.06654158040028 0.652777777777778 11.2 11 2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 4.08558857750865e-06 2.36333030316862e-05 1.06555495544153 0.652173913043478 11.2 11 2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 4.08558857750865e-06 2.36333030316862e-05 1.06555495544153 0.652173913043478 11.2 11 2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 5.14304117688408e-07 3.43593783789016e-06 1.06298735313927 0.650602409638554 11.2 11 2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 5.14304117688408e-07 3.43593783789016e-06 1.06298735313927 0.650602409638554 11.2 11 2 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.000479958613383457 0.00172035543285809 1.06200310559006 0.65 11.2 11 2 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.000479958613383457 0.00172035543285809 1.06200310559006 0.65 11.2 11 2 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.0130226045947034 0.0279083830395526 1.06200310559006 0.65 11.2 11 2 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.000824787459873478 0.00278121458625583 1.05979519892563 0.648648648648649 11.2 11 2 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.00142108189777071 0.00441877905517343 1.05719766167337 0.647058823529412 11.2 11 2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.00142108189777071 0.00441877905517343 1.05719766167337 0.647058823529412 11.2 11 2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.0231751649849987 0.0445050739185603 1.05719766167337 0.647058823529412 11.2 11 2 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 9.79796828269341e-05 0.00044121863500863 1.05719766167336 0.647058823529412 11.2 11 2 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 8.90106184670608e-07 5.75736863993762e-06 1.05602560218149 0.646341463414634 11.2 11 2 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 1.2015277633909e-05 6.30912917824816e-05 1.05571906354515 0.646153846153846 11.2 11 2 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00245601467324865 0.00707471433205025 1.0540973752755 0.645161290322581 11.2 11 2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00245601467324865 0.00707471433205025 1.0540973752755 0.645161290322581 11.2 11 2 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 6.75198492596699e-10 7.39082657665463e-09 1.05210097873141 0.643939393939394 11.2 11 2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 4.28210744686484e-06 2.45798079417731e-05 1.05193142176466 0.643835616438356 11.2 11 2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 7.23561183826991e-06 3.96010601763773e-05 1.05033274179237 0.642857142857143 11.2 11 2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.000487619903841664 0.00173038185328351 1.05033274179237 0.642857142857143 11.2 11 2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000487619903841664 0.00173038185328351 1.05033274179237 0.642857142857143 11.2 11 2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.00426016976416344 0.0111643122917211 1.05033274179237 0.642857142857143 11.2 11 2 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00426016976416344 0.0111643122917211 1.05033274179237 0.642857142857143 11.2 11 2 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 48%5604778 PURINE SALVAGE 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.0417393781852056 0.0742439189469345 1.05033274179237 0.642857142857143 11.2 11 2 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.4463805543178e-101 4.90419952879423e-98 1.04844920986892 0.641704325371207 11.2 11 2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 2.0304234631987e-15 7.97303009329616e-14 1.04771606829513 0.641255605381166 11.2 11 2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 3.24317662608615e-11 5.19251561533444e-10 1.0473403408186 0.641025641025641 11.2 11 2 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.000835401524424513 0.00281034602661012 1.0473403408186 0.641025641025641 11.2 11 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.00742216859680078 0.0180542665183718 1.04566459627329 0.64 11.2 11 2 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.00742216859680078 0.0180542665183718 1.04566459627329 0.64 11.2 11 2 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.00742216859680078 0.0180542665183718 1.04566459627329 0.64 11.2 11 2 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 3.50282688583058e-05 0.00017012022725382 1.04459321861318 0.639344262295082 11.2 11 2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 3.50282688583058e-05 0.00017012022725382 1.04459321861318 0.639344262295082 11.2 11 2 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.50282688583058e-05 0.00017012022725382 1.04459321861318 0.639344262295082 11.2 11 2 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 5.98484538049171e-17 2.93670171601369e-15 1.04384920634921 0.638888888888889 11.2 11 2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 5.98484538049171e-17 2.93670171601369e-15 1.04384920634921 0.638888888888889 11.2 11 2 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 5.98484538049171e-17 2.93670171601369e-15 1.04384920634921 0.638888888888889 11.2 11 2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 7.34313176687397e-06 4.0035542161922e-05 1.04384920634921 0.638888888888889 11.2 11 2 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00143428976747749 0.00441877905517343 1.04384920634921 0.638888888888889 11.2 11 2 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 5.5199881414637e-11 7.20636983972738e-10 1.04355640152274 0.638709677419355 11.2 11 2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 4.25713515234143e-10 4.77000261557626e-09 1.04288357341086 0.638297872340426 11.2 11 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 2.09276301454868e-05 0.000108290973443737 1.0397233201581 0.636363636363636 11.2 11 2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.00246858539396376 0.00709655962749581 1.0397233201581 0.636363636363636 11.2 11 2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.076463919822826 0.122669851079911 1.0397233201581 0.636363636363636 11.2 11 2 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 5.32626021219632e-24 5.05284552130358e-22 1.0397233201581 0.636363636363636 11.2 11 2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 3.5354392192189e-05 0.000171120068331581 1.03736567090604 0.634920634920635 11.2 11 2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 3.43570272533718e-11 5.25933155262854e-10 1.03610059081957 0.634146341463415 11.2 11 2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 7.79349141721222e-14 1.76033941058619e-12 1.03477225672878 0.633333333333333 11.2 11 2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 9.43626617503495e-07 6.05550902621416e-06 1.03477225672878 0.633333333333333 11.2 11 2 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 5.97570251594731e-05 0.000280791867597129 1.03477225672878 0.633333333333333 11.2 11 2 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 9.56962598639571e-11 1.19452436654746e-09 1.03408286815001 0.632911392405063 11.2 11 2 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.39845876225837e-09 3.11253359186052e-08 1.03190585158549 0.631578947368421 11.2 11 2 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0229270821541773 0.0445050739185603 1.03190585158549 0.631578947368421 11.2 11 2 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.65783671174446e-06 1.62321958833149e-05 1.03088213546288 0.630952380952381 11.2 11 2 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.65783671174446e-06 1.62321958833149e-05 1.03088213546288 0.630952380952381 11.2 11 2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.55189261804869e-05 0.000171333667643501 1.0305828953655 0.630769230769231 11.2 11 2 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.000492534041629009 0.00173914625617389 1.03003645692682 0.630434782608696 11.2 11 2 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.000492534041629009 0.00173914625617389 1.03003645692682 0.630434782608696 11.2 11 2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 1.22023474705928e-07 9.02344272027333e-07 1.02872095698183 0.62962962962963 11.2 11 2 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.00737943383887038 0.0180428425304339 1.02872095698183 0.62962962962963 11.2 11 2 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00737943383887038 0.0180428425304339 1.02872095698183 0.62962962962963 11.2 11 2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.00737943383887038 0.0180428425304339 1.02872095698183 0.62962962962963 11.2 11 2 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 2.03979074910868e-07 1.42986317043431e-06 1.02699201419698 0.628571428571429 11.2 11 2 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.000838098771007049 0.00281277016779017 1.02590639895999 0.627906976744186 11.2 11 2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 1.22384008785155e-07 9.02344272027333e-07 1.02487012987013 0.627272727272727 11.2 11 2 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 4.87857669029931e-33 1.15703577171599e-30 1.0215145054443 0.625218914185639 11.2 11 2 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 5.97891327350177e-05 0.000280791867597129 1.02115683229814 0.625 11.2 11 2 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.00142780637615961 0.00441877905517343 1.02115683229814 0.625 11.2 11 2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.00422531229150616 0.0111138990588045 1.02115683229814 0.625 11.2 11 2 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0128316852332417 0.0277371787273476 1.02115683229814 0.625 11.2 11 2 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0128316852332417 0.0277371787273476 1.02115683229814 0.625 11.2 11 2 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.0407848275476798 0.0741210850579162 1.02115683229814 0.625 11.2 11 2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0407848275476798 0.0741210850579162 1.02115683229814 0.625 11.2 11 2 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%REACT_212869.1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.143784113150713 0.206979791401567 1.02115683229814 0.625 11.2 11 2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 2.57739566790537e-50 1.22254467847645e-47 1.020232708468 0.624434389140271 11.2 11 2 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000287909204103263 0.00111309839810527 1.01730341028946 0.622641509433962 11.2 11 2 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 3.43399857735367e-09 3.11253359186052e-08 1.01687225817661 0.622377622377622 11.2 11 2 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.000169334976794537 0.000698445426025002 1.01411437138574 0.620689655172414 11.2 11 2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.000169334976794537 0.000698445426025002 1.01411437138574 0.620689655172414 11.2 11 2 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00727325424236079 0.0178753726889109 1.01411437138574 0.620689655172414 11.2 11 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.00727325424236079 0.0178753726889109 1.01411437138574 0.620689655172414 11.2 11 2 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00727325424236079 0.0178753726889109 1.01411437138574 0.620689655172414 11.2 11 2 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.24639296162542e-05 6.52065141320946e-05 1.01340121078701 0.620253164556962 11.2 11 2 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 9.4471047352041e-07 6.05550902621416e-06 1.01298757763975 0.62 11.2 11 2 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.000486235159677529 0.00173038185328351 1.01298757763975 0.62 11.2 11 2 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000486235159677529 0.00173038185328351 1.01298757763975 0.62 11.2 11 2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 6.35326505876565e-15 1.58608704888132e-13 1.01234685178419 0.619607843137255 11.2 11 2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.0224205235154288 0.0440668576829492 1.01143152913339 0.619047619047619 11.2 11 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.000285027673388353 0.00111121747734692 1.01001693958216 0.618181818181818 11.2 11 2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.000285027673388353 0.00111121747734692 1.01001693958216 0.618181818181818 11.2 11 2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.00416070642627558 0.0110460545608025 1.00914322250639 0.617647058823529 11.2 11 2 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 5.59228058569334e-07 3.70130942950773e-06 1.00779590178209 0.616822429906542 11.2 11 2 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.000167485325565189 0.000694844368161121 1.00754140786749 0.616666666666667 11.2 11 2 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0125545789575645 0.0273586000866988 1.00544672718586 0.615384615384615 11.2 11 2 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0125545789575645 0.0273586000866988 1.00544672718586 0.615384615384615 11.2 11 2 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.073397685524475 0.119776268923541 1.00544672718586 0.615384615384615 11.2 11 2 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 5.69285407623225e-11 7.36448304588953e-10 1.00477463712758 0.614973262032086 11.2 11 2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 1.18913379206143e-07 8.85935804242627e-07 1.00441655635882 0.614754098360656 11.2 11 2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00138830197982686 0.00434187630174422 1.00259034443817 0.613636363636364 11.2 11 2 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 1.175526478652e-07 8.80407462695684e-07 1.00139250651172 0.612903225806452 11.2 11 2 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 1.175526478652e-07 8.80407462695684e-07 1.00139250651172 0.612903225806452 11.2 11 2 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 1.175526478652e-07 8.80407462695684e-07 1.00139250651172 0.612903225806452 11.2 11 2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.000165075349126784 0.000686848601776063 1.00139250651172 0.612903225806452 11.2 11 2 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.000165075349126784 0.000686848601776063 1.00139250651172 0.612903225806452 11.2 11 2 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 5.46932245809988e-07 3.63684385882062e-06 1.00091768787421 0.612612612612613 11.2 11 2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.000471614183304904 0.00169900501985539 0.998464458247067 0.611111111111111 11.2 11 2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.000471614183304904 0.00169900501985539 0.998464458247067 0.611111111111111 11.2 11 2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.00234694827404188 0.00681572937543184 0.996250568095743 0.609756097560976 11.2 11 2 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.000162184795868596 0.000684833722614277 0.995627911490683 0.609375 11.2 11 2 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0217399810310491 0.0432066941441101 0.994517958412098 0.608695652173913 11.2 11 2 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.00046196505660737 0.00167271316934424 0.991980922803904 0.607142857142857 11.2 11 2 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00692796905695604 0.0172653239370376 0.99021268586486 0.606060606060606 11.2 11 2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 9.35043755218405e-05 0.000423747536202481 0.98951535298749 0.605633802816901 11.2 11 2 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 5.51308936337204e-05 0.00026150420546928 0.98890977443609 0.605263157894737 11.2 11 2 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.0039684371443811 0.010634813665639 0.98890977443609 0.605263157894737 11.2 11 2 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 8.38181509318765e-09 7.2727578521988e-08 0.988635914072081 0.605095541401274 11.2 11 2 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000772208032756664 0.00262883260912137 0.986476034220087 0.60377358490566 11.2 11 2 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 1.78127603263623e-07 1.25482960120859e-06 0.985299416812858 0.603053435114504 11.2 11 2 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 1.78127603263623e-07 1.25482960120859e-06 0.985299416812858 0.603053435114504 11.2 11 2 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.50233543128423e-25 1.9434757442886e-23 0.982146346569893 0.601123595505618 11.2 11 2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 3.10620451783901e-05 0.000152945641137886 0.980310559006211 0.6 11.2 11 2 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 3.10620451783901e-05 0.000152945641137886 0.980310559006211 0.6 11.2 11 2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000751493948179736 0.00256445057136634 0.980310559006211 0.6 11.2 11 2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 0.037783798493388 0.0697358563632829 0.980310559006211 0.6 11.2 11 2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.037783798493388 0.0697358563632829 0.980310559006211 0.6 11.2 11 2 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%REACT_196482.2 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.134242954451774 0.200448818661988 0.980310559006211 0.6 11.2 11 2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 6.45669272831259e-06 3.56119137689489e-05 0.980310559006211 0.6 11.2 11 2 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.08873912594803e-05 5.75938950269163e-05 0.980310559006211 0.6 11.2 11 2 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.08873912594803e-05 5.75938950269163e-05 0.980310559006211 0.6 11.2 11 2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.000151335468514072 0.000644761591902768 0.980310559006211 0.6 11.2 11 2 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.00128988743295444 0.00406086242719948 0.980310559006211 0.6 11.2 11 2 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00222301502974418 0.00649558601093629 0.980310559006211 0.6 11.2 11 2 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00671088539318265 0.0167536665166647 0.980310559006211 0.6 11.2 11 2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.00671088539318265 0.0167536665166647 0.980310559006211 0.6 11.2 11 2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.0117917475527503 0.0260149717326568 0.980310559006211 0.6 11.2 11 2 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.0117917475527503 0.0260149717326568 0.980310559006211 0.6 11.2 11 2 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.0697796821712227 0.116682124241657 0.980310559006211 0.6 11.2 11 2 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 2.16343210937971e-06 1.34435104438748e-05 0.974577748719625 0.596491228070175 11.2 11 2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 6.12759839671618e-06 3.39282977374597e-05 0.974026516961299 0.596153846153846 11.2 11 2 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00125063195649344 0.00394600725962341 0.974026516961299 0.596153846153846 11.2 11 2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.00215266950489942 0.00630298087545654 0.973358001850139 0.595744680851064 11.2 11 2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0037226795517005 0.0101677024991743 0.972530316474416 0.595238095238095 11.2 11 2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0037226795517005 0.0101677024991743 0.972530316474416 0.595238095238095 11.2 11 2 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.000142887531772118 0.000619905358877209 0.971478932348497 0.594594594594595 11.2 11 2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.000142887531772118 0.000619905358877209 0.971478932348497 0.594594594594595 11.2 11 2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.0113474989873017 0.0254291197778431 0.97009899068323 0.59375 11.2 11 2 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 4.82642916716626e-05 0.000231246084339313 0.968911599017767 0.593023255813954 11.2 11 2 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0200820627665742 0.041236328018521 0.968207959512307 0.592592592592593 11.2 11 2 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000138448794549062 0.000604333235102194 0.967411735861393 0.592105263157895 11.2 11 2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.0360266189142102 0.066665642022004 0.965457368718238 0.590909090909091 11.2 11 2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.0360266189142102 0.066665642022004 0.965457368718238 0.590909090909091 11.2 11 2 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0360266189142102 0.066665642022004 0.965457368718238 0.590909090909091 11.2 11 2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.06594148835151 0.110915765867847 0.961088783339423 0.588235294117647 11.2 11 2 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.06594148835151 0.110915765867847 0.961088783339423 0.588235294117647 11.2 11 2 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.27846261876331e-07 9.32949900769327e-07 0.959228611500701 0.587096774193548 11.2 11 2 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.00112355584943317 0.0036167599690813 0.957774684086528 0.586206896551724 11.2 11 2 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.00112355584943317 0.0036167599690813 0.957774684086528 0.586206896551724 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.00112355584943317 0.0036167599690813 0.957774684086528 0.586206896551724 11.2 11 2 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 2.99270511593753e-14 6.98134324586737e-13 0.957256220706474 0.585889570552147 11.2 11 2 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.000372182458237402 0.00138280845449562 0.956969831410825 0.585714285714286 11.2 11 2 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.00597279635127482 0.0152890126340356 0.956400545371913 0.585365853658537 11.2 11 2 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00330931941215007 0.00923365004605794 0.953079710144928 0.583333333333333 11.2 11 2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0342115951479795 0.0635549606991839 0.953079710144928 0.583333333333333 11.2 11 2 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0342115951479795 0.0635549606991839 0.953079710144928 0.583333333333333 11.2 11 2 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.124718690618355 0.188602228214579 0.953079710144928 0.583333333333333 11.2 11 2 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.00184657145286981 0.00547431495298694 0.950604178430265 0.581818181818182 11.2 11 2 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 2.49279793146093e-09 2.38070567548249e-08 0.94918958887903 0.580952380952381 11.2 11 2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0182621202057802 0.0377197528330738 0.948687637747946 0.580645161290323 11.2 11 2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.0182621202057802 0.0377197528330738 0.948687637747946 0.580645161290323 11.2 11 2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.000195220884755128 0.000793712340018707 0.948036960355801 0.580246913580247 11.2 11 2 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.000583892604043437 0.00202653457452149 0.947159960392475 0.579710144927536 11.2 11 2 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 2.15115827546679e-05 0.000110508961227049 0.946717362280142 0.579439252336449 11.2 11 2 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 6.32790948342379e-05 0.000293309941202347 0.945913697286695 0.578947368421053 11.2 11 2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0620689709940981 0.10527311766937 0.945913697286695 0.578947368421053 11.2 11 2 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 5.57379180181628e-25 6.1011582569112e-23 0.94524501801532 0.578538102643857 11.2 11 2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.032388752774728 0.0603261717257041 0.942606306736742 0.576923076923077 11.2 11 2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.032388752774728 0.0603261717257041 0.942606306736742 0.576923076923077 11.2 11 2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.00169118059817276 0.00517537632516093 0.941541214864723 0.576271186440678 11.2 11 2 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00169118059817276 0.00517537632516093 0.941541214864723 0.576271186440678 11.2 11 2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.0173454324641994 0.0359803941640755 0.940702051571617 0.575757575757576 11.2 11 2 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 0.00944395656290754 0.0215364586362459 0.939464285714286 0.575 11.2 11 2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 9.78667763275981e-05 0.00044121863500863 0.938595216069777 0.574468085106383 11.2 11 2 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.348699284066e-18 1.59152337201234e-16 0.934100633665851 0.571717171717172 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 2.91979740677672e-05 0.000146584272824692 0.933629103815439 0.571428571428571 11.2 11 2 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0049500870959743 0.0129010511677132 0.933629103815439 0.571428571428571 11.2 11 2 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00897295208404061 0.0205612090428177 0.933629103815439 0.571428571428571 11.2 11 2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.016441622710922 0.034305614541997 0.933629103815439 0.571428571428571 11.2 11 2 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.0305913268798741 0.0578875773272085 0.933629103815439 0.571428571428571 11.2 11 2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.0305913268798741 0.0578875773272085 0.933629103815439 0.571428571428571 11.2 11 2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.115608761976834 0.176514236365917 0.933629103815439 0.571428571428571 11.2 11 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000252256110976979 0.000994350265707038 0.928324392998306 0.568181818181818 11.2 11 2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 9.22154005453469e-08 7.09310891762317e-07 0.927550789337474 0.567708333333333 11.2 11 2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0155590957016184 0.0325596958579456 0.927320799059929 0.567567567567568 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0155590957016184 0.0325596958579456 0.927320799059929 0.567567567567568 11.2 11 2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0155590957016184 0.0325596958579456 0.927320799059929 0.567567567567568 11.2 11 2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.0288411769783738 0.0547213264536346 0.925848861283644 0.566666666666667 11.2 11 2 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00132811781872178 0.0041628010044958 0.923480961382663 0.565217391304348 11.2 11 2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.00806575986099952 0.0188465948804636 0.923480961382663 0.565217391304348 11.2 11 2 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0545992481623198 0.0931455889195265 0.923480961382663 0.565217391304348 11.2 11 2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.0545992481623198 0.0931455889195265 0.923480961382663 0.565217391304348 11.2 11 2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.000383626909814873 0.00142161742881918 0.920214892553723 0.563218390804598 11.2 11 2 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 8.41768877400342e-17 3.86399068561512e-15 0.919871357875069 0.563008130081301 11.2 11 2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00763380755166843 0.0183805552386196 0.919041149068323 0.5625 11.2 11 2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0271523474866811 0.0517239497637848 0.919041149068323 0.5625 11.2 11 2 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0271523474866811 0.0517239497637848 0.919041149068323 0.5625 11.2 11 2 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.107058780972921 0.164519055425989 0.919041149068323 0.5625 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0138793279444382 0.0295662929115802 0.916550522648084 0.560975609756098 11.2 11 2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.00721804964791628 0.0178753726889109 0.91495652173913 0.56 11.2 11 2 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0510951305517133 0.0900971137237771 0.91495652173913 0.56 11.2 11 2 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0510951305517133 0.0900971137237771 0.91495652173913 0.56 11.2 11 2 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 8.52372894824408e-10 8.98464169877876e-09 0.914248716281364 0.55956678700361 11.2 11 2 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0255334584959527 0.0487706193822022 0.913034344172452 0.558823529411765 11.2 11 2 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0255334584959527 0.0487706193822022 0.913034344172452 0.558823529411765 11.2 11 2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0255334584959527 0.0487706193822022 0.913034344172452 0.558823529411765 11.2 11 2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.00643770474611675 0.0161852541585232 0.907694962042788 0.555555555555556 11.2 11 2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0477721152849204 0.0845518906100022 0.907694962042788 0.555555555555556 11.2 11 2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.000966867316359681 0.00322213627910966 0.907694962042788 0.555555555555556 11.2 11 2 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00180672416870723 0.00540119431107224 0.907694962042788 0.555555555555556 11.2 11 2 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.0123326014691303 0.0271101194290184 0.907694962042788 0.555555555555556 11.2 11 2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.099108501971902 0.153628974189561 0.907694962042788 0.555555555555556 11.2 11 2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.099108501971902 0.153628974189561 0.907694962042788 0.555555555555556 11.2 11 2 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME%REACT_204269.1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.225560306548371 0.304239162292258 0.907694962042788 0.555555555555556 11.2 11 2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 4.36158040532016e-29 7.75816114596323e-27 0.901153016370408 0.551551551551552 11.2 11 2 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0109274644745658 0.0245264699484339 0.900285207250602 0.551020408163265 11.2 11 2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.0917508484949661 0.14269011738616 0.89861801242236 0.55 11.2 11 2 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.0917508484949661 0.14269011738616 0.89861801242236 0.55 11.2 11 2 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.000297243423246664 0.00111309839810527 0.891191417278374 0.545454545454545 11.2 11 2 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.0849580205904151 0.132763952281545 0.891191417278374 0.545454545454545 11.2 11 2 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.203577796006512 0.278817327928071 0.891191417278374 0.545454545454545 11.2 11 2 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.00398943406767095 0.010670986237398 0.886947648624667 0.542857142857143 11.2 11 2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.016314056650787 0.0340894311513507 0.885002587991718 0.541666666666667 11.2 11 2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.0786937471792671 0.123191641623869 0.885002587991718 0.541666666666667 11.2 11 2 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.00752321620345597 0.0182688338865492 0.883886569595764 0.540983606557377 11.2 11 2 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.00331674089958513 0.00923624716264118 0.881419581562602 0.539473684210526 11.2 11 2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0729192379581963 0.119776268923541 0.879765886287625 0.538461538461538 11.2 11 2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.184593196561215 0.255521516251565 0.879765886287625 0.538461538461538 11.2 11 2 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.0626877441106527 0.105818101861754 0.871387163561076 0.533333333333333 11.2 11 2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0626877441106527 0.105818101861754 0.871387163561076 0.533333333333333 11.2 11 2 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.167984853183247 0.233896718277652 0.871387163561076 0.533333333333333 11.2 11 2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.167984853183247 0.233896718277652 0.871387163561076 0.533333333333333 11.2 11 2 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 4.32376104616673e-11 6.47653891441605e-10 0.868212266384425 0.531390134529148 11.2 11 2 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0224032478065153 0.0440668576829492 0.866941310685765 0.530612244897959 11.2 11 2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.153315735172008 0.217515743918013 0.86497990500548 0.529411764705882 11.2 11 2 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.153315735172008 0.217515743918013 0.86497990500548 0.529411764705882 11.2 11 2 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.153315735172008 0.217515743918013 0.86497990500548 0.529411764705882 11.2 11 2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.140263536391684 0.206979791401567 0.859921542987904 0.526315789473684 11.2 11 2 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000779215701996904 0.00264635786143579 0.857102128092862 0.524590163934426 11.2 11 2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.128581800195695 0.194031709097003 0.855826678497486 0.523809523809524 11.2 11 2 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.128581800195695 0.194031709097003 0.855826678497486 0.523809523809524 11.2 11 2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 8.71530669214757e-05 0.000397496199452756 0.854921999133324 0.523255813953488 11.2 11 2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.118076681421065 0.180089086454636 0.852443964353227 0.521739130434783 11.2 11 2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.108592248525784 0.16669554439287 0.84960248447205 0.52 11.2 11 2 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.100000754683263 0.154843388372451 0.847181964573269 0.518518518518518 11.2 11 2 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 5.36602287808332e-05 0.000255379617241223 0.845953274269319 0.517766497461929 11.2 11 2 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0850883517082005 0.132763952281545 0.843277900220397 0.516129032258065 11.2 11 2 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0850883517082005 0.132763952281545 0.843277900220397 0.516129032258065 11.2 11 2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0183477729546578 0.0377295966972227 0.842454386645963 0.515625 11.2 11 2 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.0726707552334162 0.119549693291504 0.840266193433895 0.514285714285714 11.2 11 2 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0622559974621349 0.105339220438309 0.837872272654882 0.512820512820513 11.2 11 2 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0622559974621349 0.105339220438309 0.837872272654882 0.512820512820513 11.2 11 2 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0275996888631138 0.0525058252034905 0.83031768658996 0.508196721311475 11.2 11 2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00901073107272118 0.020614582502383 0.825709610632472 0.505376344086022 11.2 11 2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0141285703800129 0.0297564228438056 0.816925465838509 0.5 11.2 11 2 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.0644127795629483 0.108601167438478 0.816925465838509 0.5 11.2 11 2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.132405407460397 0.199589930949307 0.816925465838509 0.5 11.2 11 2 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.172205579800975 0.239539139840457 0.816925465838509 0.5 11.2 11 2 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.188776224288401 0.261057888398829 0.816925465838509 0.5 11.2 11 2 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.207522968372114 0.28394729230146 0.816925465838509 0.5 11.2 11 2 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.228910925393573 0.307302119655712 0.816925465838509 0.5 11.2 11 2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.282436901394669 0.368694128642978 0.816925465838509 0.5 11.2 11 2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.282436901394669 0.368694128642978 0.816925465838509 0.5 11.2 11 2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.316877658644968 0.410671136841339 0.816925465838509 0.5 11.2 11 2 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.316877658644968 0.410671136841339 0.816925465838509 0.5 11.2 11 2 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00934183560575601 0.0213377721781554 0.816925465838509 0.5 11.2 11 2 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.121704160271655 0.185224620392047 0.816925465838509 0.5 11.2 11 2 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.121704160271655 0.185224620392047 0.816925465838509 0.5 11.2 11 2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0014737696094152 0.00452953381036249 0.811913653164653 0.496932515337423 11.2 11 2 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.0484689580878942 0.0856786675267993 0.803533245087058 0.491803278688525 11.2 11 2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0561966828467859 0.0955410748996133 0.802593440122044 0.491228070175439 11.2 11 2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.0605507352219617 0.102820639881684 0.802072275550536 0.490909090909091 11.2 11 2 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.00260279312030385 0.00737803707209638 0.801703252189345 0.490683229813665 11.2 11 2 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.00321067898764537 0.00897602396742508 0.796754466682003 0.487654320987654 11.2 11 2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.000648209180804129 0.00223341807332755 0.792382640684563 0.484978540772532 11.2 11 2 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.143466094739622 0.206979791401567 0.792170148691888 0.484848484848485 11.2 11 2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.00449184475373538 0.011728247861588 0.791235985780694 0.484276729559748 11.2 11 2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.00449184475373538 0.011728247861588 0.791235985780694 0.484276729559748 11.2 11 2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.00234520638703665 0.00681572937543184 0.790573031456622 0.483870967741935 11.2 11 2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0051240321180502 0.0132814165828514 0.790573031456622 0.483870967741935 11.2 11 2 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.156031480799892 0.218428204617768 0.790573031456622 0.483870967741935 11.2 11 2 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.0880431271914032 0.137223844461519 0.785505255613951 0.480769230769231 11.2 11 2 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.202567954558629 0.278817327928071 0.784248447204969 0.48 11.2 11 2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.202567954558629 0.278817327928071 0.784248447204969 0.48 11.2 11 2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.202567954558629 0.278817327928071 0.784248447204969 0.48 11.2 11 2 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.0105787754835793 0.0237813546810954 0.78191437444543 0.478571428571429 11.2 11 2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.221823736649225 0.302932031911561 0.781406967323792 0.478260869565217 11.2 11 2 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.0747634065013659 0.121865208993635 0.778024253179533 0.476190476190476 11.2 11 2 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.243498428009043 0.325962618115587 0.778024253179533 0.476190476190476 11.2 11 2 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.0145855186497705 0.03065759680742 0.775184748605885 0.474452554744526 11.2 11 2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.2680564571545 0.355824942659378 0.773929388689114 0.473684210526316 11.2 11 2 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.10053053286756 0.155494508989714 0.772365894974591 0.472727272727273 11.2 11 2 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.296106650034965 0.385155176416596 0.768871026671538 0.470588235294118 11.2 11 2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.0222928499098951 0.0440668576829492 0.763258829396563 0.467153284671533 11.2 11 2 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.32847131186265 0.41696224512092 0.762463768115942 0.466666666666667 11.2 11 2 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.32847131186265 0.41696224512092 0.762463768115942 0.466666666666667 11.2 11 2 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.32847131186265 0.41696224512092 0.762463768115942 0.466666666666667 11.2 11 2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.0232442635129605 0.0445776104837503 0.759395503455516 0.464788732394366 11.2 11 2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.0281839471050486 0.0535457366228092 0.756857416879795 0.463235294117647 11.2 11 2 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.252541693528849 0.335856850365937 0.754085045389393 0.461538461538462 11.2 11 2 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.366302934109058 0.457236030909815 0.754085045389393 0.461538461538462 11.2 11 2 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.237702976124879 0.318504081945106 0.742659514398645 0.454545454545455 11.2 11 2 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.237702976124879 0.318504081945106 0.742659514398645 0.454545454545455 11.2 11 2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.302909134849101 0.393643560630384 0.742659514398645 0.454545454545455 11.2 11 2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%REACT_210612.1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 0.411294210843682 0.501305866131068 0.742659514398645 0.454545454545455 11.2 11 2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.332922102226763 0.421859440310493 0.735232919254658 0.45 11.2 11 2 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.332922102226763 0.421859440310493 0.735232919254658 0.45 11.2 11 2 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.142904418403219 0.206979791401567 0.734048969304168 0.449275362318841 11.2 11 2 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.281103386594541 0.368694128642978 0.732415934889698 0.448275862068966 11.2 11 2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.281103386594541 0.368694128642978 0.732415934889698 0.448275862068966 11.2 11 2 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.123701729581775 0.188063633755199 0.72615596963423 0.444444444444444 11.2 11 2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.227455205842116 0.306504505599745 0.72615596963423 0.444444444444444 11.2 11 2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.0919078952306117 0.142778313223974 0.720438206093803 0.440944881889764 11.2 11 2 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.334206759232768 0.422734416345093 0.718894409937888 0.44 11.2 11 2 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.334206759232768 0.422734416345093 0.718894409937888 0.44 11.2 11 2 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.264417854134004 0.351322695081875 0.717300409028935 0.439024390243902 11.2 11 2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0454839265121894 0.0806022757494964 0.708658235426177 0.433734939759036 11.2 11 2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.362539412537411 0.454531792106375 0.700221827861579 0.428571428571429 11.2 11 2 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.399989857890053 0.490254580342416 0.700221827861579 0.428571428571429 11.2 11 2 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.450846911331655 0.543690809173682 0.700221827861579 0.428571428571429 11.2 11 2 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.450846911331655 0.543690809173682 0.700221827861579 0.428571428571429 11.2 11 2 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.450846911331655 0.543690809173682 0.700221827861579 0.428571428571429 11.2 11 2 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.285092494010805 0.371167995404735 0.695899470899471 0.425925925925926 11.2 11 2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.359285646157263 0.450849624763479 0.693148880105402 0.424242424242424 11.2 11 2 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.438913332245789 0.531100061042311 0.687937234390324 0.421052631578947 11.2 11 2 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.438913332245789 0.531100061042311 0.687937234390324 0.421052631578947 11.2 11 2 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.388374605844099 0.476428503548407 0.685163293929072 0.419354838709677 11.2 11 2 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.323366683599549 0.411583891558281 0.683246753246753 0.418181818181818 11.2 11 2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.503335146164405 0.596374615313862 0.680771221532091 0.416666666666667 11.2 11 2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.482767530584476 0.578751639445417 0.672762148337596 0.411764705882353 11.2 11 2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.211501772404639 0.289113373805764 0.671203625986235 0.410810810810811 11.2 11 2 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.349810849649215 0.442078897913706 0.667347563642726 0.408450704225352 11.2 11 2 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.454466486525606 0.547591710690887 0.665642972164711 0.407407407407407 11.2 11 2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.443569517569054 0.536278184792493 0.663751940993789 0.40625 11.2 11 2 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.509574152258473 0.603264574595514 0.653540372670807 0.4 11.2 11 2 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.477477109977343 0.572892013067251 0.653540372670807 0.4 11.2 11 2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.315274781967271 0.409339429506776 0.647133114115211 0.396078431372549 11.2 11 2 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.513948710870909 0.607937668802413 0.641870008873114 0.392857142857143 11.2 11 2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.55645458026944 0.653868594321564 0.635386473429952 0.388888888888889 11.2 11 2 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.22363380290771 0.304239162292258 0.633615361308893 0.38780487804878 11.2 11 2 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.533752375745708 0.629888501642676 0.632458425165297 0.387096774193548 11.2 11 2 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.533752375745708 0.629888501642676 0.632458425165297 0.387096774193548 11.2 11 2 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%REACT_216080.1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 0.588980278698998 0.68642009548622 0.628404204491161 0.384615384615385 11.2 11 2 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.551759221224859 0.64888708413469 0.624707709170625 0.382352941176471 11.2 11 2 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.565524404702716 0.659666301920414 0.616547521387554 0.377358490566038 11.2 11 2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.608344730094426 0.70428811907903 0.612694099378882 0.375 11.2 11 2 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.608344730094426 0.70428811907903 0.612694099378882 0.375 11.2 11 2 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.609813601958832 0.70428811907903 0.607712846538403 0.371951219512195 11.2 11 2 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.602958376975352 0.702135655021216 0.606858917480036 0.371428571428571 11.2 11 2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.625693277352659 0.713270218792226 0.59907867494824 0.366666666666667 11.2 11 2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.653047627824867 0.740042632532073 0.590967358266156 0.361702127659574 11.2 11 2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.665721038347522 0.750650584444156 0.58351818988465 0.357142857142857 11.2 11 2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.717231342437334 0.80809200339535 0.580924775707384 0.355555555555556 11.2 11 2 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.755405508792319 0.835910069784835 0.574873475960433 0.351851851851852 11.2 11 2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.729633510115473 0.816407366805844 0.566846241602231 0.346938775510204 11.2 11 2 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.843562426630042 0.917027629891046 0.549853678929766 0.336538461538462 11.2 11 2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.737034786424153 0.819375391469976 0.544616977225673 0.333333333333333 11.2 11 2 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.74775474638596 0.829996103047754 0.544616977225673 0.333333333333333 11.2 11 2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.74775474638596 0.829996103047754 0.544616977225673 0.333333333333333 11.2 11 2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 48%5605108 RECYCLING OF BILE ACIDS AND SALTS 0.732366235365788 0.816407366805844 0.544616977225673 0.333333333333333 11.2 11 2 ANDROGEN BIOSYNTHESIS%REACTOME%REACT_220332.1 ANDROGEN BIOSYNTHESIS 0.732366235365788 0.816407366805844 0.544616977225673 0.333333333333333 11.2 11 2 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.804975655505227 0.879785221032211 0.529897599462817 0.324324324324324 11.2 11 2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.792333501218327 0.86863680449436 0.522832298136646 0.32 11.2 11 2 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.900116736560956 0.96450761756494 0.517041434075006 0.316455696202532 11.2 11 2 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.836099065892744 0.912399517458109 0.515952925792743 0.315789473684211 11.2 11 2 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.96132193847187 1 0.488470897099315 0.298969072164948 11.2 11 2 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.972026240722951 1 0.478602798168016 0.292929292929293 11.2 11 2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.888735744983638 0.955189550688608 0.474343818873973 0.290322580645161 11.2 11 2 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.923840919721009 0.983265242156317 0.46681455190772 0.285714285714286 11.2 11 2 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.897552237819709 0.962484426840578 0.445595708639187 0.272727272727273 11.2 11 2 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.897552237819709 0.962484426840578 0.445595708639187 0.272727272727273 11.2 11 2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.96952394670644 1 0.417961866242958 0.255813953488372 11.2 11 2 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999935059731 1 0.416884644938208 0.255154639175258 11.2 11 2 MISCELLANEOUS SUBSTRATES%REACTOME%REACT_216259.1 MISCELLANEOUS SUBSTRATES 0.927039169545555 0.98593179242401 0.408462732919255 0.25 11.2 11 2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.979942350775294 1 0.408462732919255 0.25 11.2 11 2 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999992358733548 1 0.399051149211438 0.244239631336406 11.2 11 2 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999979553651 1 0.373451641526176 0.228571428571429 11.2 11 2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.981361209895267 1 0.373451641526176 0.228571428571429 11.2 11 2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.994259971163883 1 0.369928512832533 0.226415094339623 11.2 11 2 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999998998949286 1 0.352763269339356 0.215909090909091 11.2 11 2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.989695503741609 1 0.326770186335404 0.2 11.2 11 2 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.315521170684899 0.19311502938707 11.2 11 2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.99964795958227 1 0.272308488612836 0.166666666666667 11.2 11 2 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.267384284478789 0.163652802893309 11.2 11 2 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.997906158740144 1 0.263524343818874 0.161290322580645 11.2 11 2 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0289876778200761 0.017741935483871 11.2 11 2 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%REACT_213224.1 FGFR3B LIGAND BINDING AND ACTIVATION 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 48%5605129 ATTACHMENT OF GPI ANCHOR TO UPAR 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 CREB PHOSPHORYLATION%REACTOME%REACT_224314.1 CREB PHOSPHORYLATION 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 UBIQUINOL BIOSYNTHESIS%REACTOME%REACT_196568.2 UBIQUINOL BIOSYNTHESIS 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.000875763646027244 0.00280047565909386 1.73360193392425 1 11.3 11 3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%REACT_196603.2 SCAVENGING BY CLASS F RECEPTORS 0.00239472358480749 0.00664267380347184 1.73360193392425 1 11.3 11 3 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 1.56563629716227e-05 7.78986171630041e-05 1.73360193392425 1 11.3 11 3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 4.28201527273883e-05 0.000182982214207428 1.73360193392425 1 11.3 11 3 HUR STABILIZES MRNA%REACTOME%REACT_198691.2 HUR STABILIZES MRNA 4.28201527273883e-05 0.000182982214207428 1.73360193392425 1 11.3 11 3 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604678 LYSINE CATABOLISM 0.000320255226042277 0.00110612423946155 1.73360193392425 1 11.3 11 3 HSF1 ACTIVATION%REACTOME%REACT_225256.1 HSF1 ACTIVATION 0.000320255226042277 0.00110612423946155 1.73360193392425 1 11.3 11 3 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 0.000320255226042277 0.00110612423946155 1.73360193392425 1 11.3 11 3 SMAC-MEDIATED APOPTOTIC RESPONSE%REACTOME%REACT_223052.1 SMAC-MEDIATED APOPTOTIC RESPONSE 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SULFIDE OXIDATION TO SULFATE%REACTOME%REACT_198963.2 SULFIDE OXIDATION TO SULFATE 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SMAC BINDS TO IAPS%REACTOME%REACT_223546.1 SMAC BINDS TO IAPS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 48%5605148 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%REACT_217163.1 SMAC-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605631 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604906 ASSEMBLY OF THE RAD51-SSDNA NUCLEOPROTEIN COMPLEX 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605656 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 48%5604853 ATM MEDIATED PHOSPHORYLATION OF REPAIR PROTEINS 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 48%5604888 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK%REACTOME DATABASE ID RELEASE 48%5604844 ATM MEDIATED RESPONSE TO DNA DOUBLE-STRAND BREAK 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%REACT_196520.2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION 0.00654789433882185 0.015720904137326 1.73360193392425 1 11.3 11 3 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 48%5605124 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS 2.84644373373329e-08 2.36870727082016e-07 1.58913510609723 0.916666666666667 11.3 11 3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%REACT_209428.1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF) 0.00012491065845378 0.000470232452327327 1.58913510609723 0.916666666666667 11.3 11 3 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 0.00012491065845378 0.000470232452327327 1.58913510609723 0.916666666666667 11.3 11 3 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.00012491065845378 0.000470232452327327 1.58913510609723 0.916666666666667 11.3 11 3 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%REACT_210562.1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 0.000314458050285043 0.00109644642779317 1.57600175811296 0.909090909090909 11.3 11 3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%REACT_196614.2 ESTABLISHMENT OF SISTER CHROMATID COHESION 0.000314458050285043 0.00109644642779317 1.57600175811296 0.909090909090909 11.3 11 3 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.000785689893697496 0.00256430440076041 1.56024174053183 0.9 11.3 11 3 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 6.73682704203645e-06 3.9128591350277e-05 1.54097949682156 0.888888888888889 11.3 11 3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 GOLGI TO ER RETROGRADE TRANSPORT%REACTOME%REACT_207127.1 GOLGI TO ER RETROGRADE TRANSPORT 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 COPI MEDIATED TRANSPORT%REACTOME%REACT_227904.1 COPI MEDIATED TRANSPORT 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 S6K1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605158 S6K1-MEDIATED SIGNALLING 0.0019454400197853 0.00560396993553539 1.54097949682156 0.888888888888889 11.3 11 3 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 1.64503027414828e-05 8.12804888928127e-05 1.52964876522728 0.882352941176471 11.3 11 3 SIGNALING BY FGFR1 FUSION MUTANTS%REACTOME%REACT_196460.2 SIGNALING BY FGFR1 FUSION MUTANTS 3.98939292819083e-05 0.00017307640661023 1.51690169218372 0.875 11.3 11 3 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 3.98939292819083e-05 0.00017307640661023 1.51690169218372 0.875 11.3 11 3 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 3.98939292819083e-05 0.00017307640661023 1.51690169218372 0.875 11.3 11 3 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 48%5604650 GLUCURONIDATION 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604850 RECRUITMENT OF REPAIR AND SIGNALING PROTEINS TO DOUBLE-STRAND BREAKS 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 SIGNALING BY LEPTIN%REACTOME%REACT_169390.2 SIGNALING BY LEPTIN 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 48%5605597 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 TNF SIGNALING%REACTOME DATABASE ID RELEASE 48%5604854 TNF SIGNALING 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 NICOTINATE METABOLISM%REACTOME%REACT_209575.1 NICOTINATE METABOLISM 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00476432258592201 0.0119323383255093 1.51690169218372 0.875 11.3 11 3 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 48%5604620 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 48%5605123 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 HOMOLOGOUS RECOMBINATION REPAIR%REACTOME DATABASE ID RELEASE 48%5604846 HOMOLOGOUS RECOMBINATION REPAIR 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS%REACTOME DATABASE ID RELEASE 48%5604845 HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION-INDEPENDENT DOUBLE-STRAND BREAKS 9.60011066345864e-05 0.000371221670491893 1.50245500940102 0.866666666666667 11.3 11 3 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 2.14305202734807e-06 1.40532858751903e-05 1.49720167020731 0.863636363636364 11.3 11 3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.000228995662740816 0.000819210396474225 1.48594451479222 0.857142857142857 11.3 11 3 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 48%5604621 REMOVAL OF THE FLAP INTERMEDIATE 0.000228995662740816 0.000819210396474225 1.48594451479222 0.857142857142857 11.3 11 3 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%REACT_220352.1 FORMATION OF ANNULAR GAP JUNCTIONS 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 48%5605659 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605149 CHREBP ACTIVATES METABOLIC GENE EXPRESSION 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%REACT_223399.1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS 0.0115084832174889 0.0257898765645461 1.48594451479222 0.857142857142857 11.3 11 3 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604619 LAGGING STRAND SYNTHESIS 1.19906341542216e-05 6.13765194297025e-05 1.47356164383562 0.85 11.3 11 3 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 1.19906341542216e-05 6.13765194297025e-05 1.47356164383562 0.85 11.3 11 3 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.000540761270397811 0.00181486624475492 1.46689394408975 0.846153846153846 11.3 11 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.97398831885479e-12 7.42453575040416e-11 1.46166437566163 0.843137254901961 11.3 11 3 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 2.97398831885479e-12 7.42453575040416e-11 1.46166437566163 0.843137254901961 11.3 11 3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 1.52179457191707e-06 1.00255262770278e-05 1.45622562449637 0.84 11.3 11 3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 1.52179457191707e-06 1.00255262770278e-05 1.45622562449637 0.84 11.3 11 3 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 1.52179457191707e-06 1.00255262770278e-05 1.45622562449637 0.84 11.3 11 3 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 3.65032587890895e-11 5.33608905821178e-10 1.44466827827021 0.833333333333333 11.3 11 3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 1.10497286016104e-08 9.76631291931159e-08 1.44466827827021 0.833333333333333 11.3 11 3 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 6.50176812387148e-05 0.000269738076975776 1.44466827827021 0.833333333333333 11.3 11 3 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_223154.1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605655 BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604896 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 INTERLEUKIN-7 SIGNALING%REACTOME%REACT_198701.2 INTERLEUKIN-7 SIGNALING 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00126219500944136 0.00386258816867753 1.44466827827021 0.833333333333333 11.3 11 3 LINOLEIC ACID (LA) METABOLISM%REACTOME%REACT_196530.2 LINOLEIC ACID (LA) METABOLISM 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 RSK ACTIVATION%REACTOME%REACT_198245.2 RSK ACTIVATION 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604872 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 48%5604871 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 RELEASE OF EIF4E%REACTOME DATABASE ID RELEASE 48%5605156 RELEASE OF EIF4E 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%REACT_214733.1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604909 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT%REACTOME DATABASE ID RELEASE 48%5605065 NEUROTRANSMITTER CLEARANCE IN THE SYNAPTIC CLEFT 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 ACTIVATION OF C3 AND C5%REACTOME%REACT_213087.1 ACTIVATION OF C3 AND C5 0.0273137481088937 0.0545891342120165 1.44466827827021 0.833333333333333 11.3 11 3 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 8.06182746428246e-06 4.29662190324867e-05 1.43210594541569 0.826086956521739 11.3 11 3 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 8.06182746428246e-06 4.29662190324867e-05 1.43210594541569 0.826086956521739 11.3 11 3 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000149297519803894 0.000548967366100622 1.4276721808788 0.823529411764706 11.3 11 3 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.000149297519803894 0.000548967366100622 1.4276721808788 0.823529411764706 11.3 11 3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.000149297519803894 0.000548967366100622 1.4276721808788 0.823529411764706 11.3 11 3 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 1.83356218193873e-05 8.96618207869008e-05 1.41840158230166 0.818181818181818 11.3 11 3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 1.83356218193873e-05 8.96618207869008e-05 1.41840158230166 0.818181818181818 11.3 11 3 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605157 MTORC1-MEDIATED SIGNALLING 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD%REACTOME DATABASE ID RELEASE 48%5605086 A THIRD PROTEOLYTIC CLEAVAGE RELEASES NICD 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS%REACTOME DATABASE ID RELEASE 48%5605142 HORMONE-SENSITIVE LIPASE (HSL)-MEDIATED TRIACYLGLYCEROL HYDROLYSIS 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%REACT_216529.1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%REACT_215668.1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS 0.00290623318905354 0.00777362749628418 1.41840158230166 0.818181818181818 11.3 11 3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 2.30307292079217e-06 1.49647158277957e-05 1.4125645387531 0.814814814814815 11.3 11 3 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.000339132208496192 0.00116006041512039 1.40855157131346 0.8125 11.3 11 3 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.29968740996754e-30 5.86931898047976e-28 1.39771655922643 0.80625 11.3 11 3 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 1.42638382945347e-09 1.65019852789617e-08 1.39441894685212 0.804347826086957 11.3 11 3 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 1.45681968104209e-06 9.7326497940042e-06 1.3868815471394 0.8 11.3 11 3 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 48%5604901 PROCESSING OF INTRONLESS PRE-MRNAS 0.000760973887165737 0.00250938629483473 1.3868815471394 0.8 11.3 11 3 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 1.14917199636766e-05 5.96814507602619e-05 1.3868815471394 0.8 11.3 11 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 9.22501168154142e-05 0.000361630623218552 1.3868815471394 0.8 11.3 11 3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%REACT_198240.2 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%REACT_204811.1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK%REACTOME DATABASE ID RELEASE 48%5605531 REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%REACT_218614.1 REGULATED PROTEOLYSIS OF P75NTR 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605645 MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%REACT_208887.1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00658444052413653 0.015720904137326 1.3868815471394 0.8 11.3 11 3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 4.11519147020113e-07 2.95753407176576e-06 1.37668388870455 0.794117647058823 11.3 11 3 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 3.20903178576006e-06 2.04773642651864e-05 1.37492567173303 0.793103448275862 11.3 11 3 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 3.20903178576006e-06 2.04773642651864e-05 1.37492567173303 0.793103448275862 11.3 11 3 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 2.53368091575338e-05 0.000115558587920418 1.3724348643567 0.791666666666667 11.3 11 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%REACT_225604.1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605739 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604617 LEADING STRAND SYNTHESIS 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 48%5604616 POLYMERASE SWITCHING 0.00168390183180679 0.00492031274468391 1.3621158052262 0.785714285714286 11.3 11 3 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 1.23577830485838e-09 1.46542710651123e-08 1.35968779131314 0.784313725490196 11.3 11 3 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 9.37372751014298e-09 8.33675890433341e-08 1.35673194828855 0.782608695652174 11.3 11 3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 5.53212814977648e-05 0.000233596983891155 1.35673194828855 0.782608695652174 11.3 11 3 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 1.51852433048514e-05 7.58196534133458e-05 1.34835705971886 0.777777777777778 11.3 11 3 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 1.51852433048514e-05 7.58196534133458e-05 1.34835705971886 0.777777777777778 11.3 11 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 48%5605515 ROLE OF ABL IN ROBO-SLIT SIGNALING 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%REACT_221573.1 VITAMIN B5 (PANTOTHENATE) METABOLISM 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 ER TO GOLGI TRANSPORT%REACTOME%REACT_203486.1 ER TO GOLGI TRANSPORT 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX%REACTOME DATABASE ID RELEASE 48%5604861 IMPORT OF PALMITOYL-COA INTO THE MITOCHONDRIAL MATRIX 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT%REACTOME%REACT_205304.1 COPII (COAT PROTEIN 2) MEDIATED VESICLE TRANSPORT 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0146304115674005 0.0320786990145007 1.34835705971886 0.777777777777778 11.3 11 3 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 1.22914186966801e-14 5.46584025167994e-13 1.34609091340001 0.776470588235294 11.3 11 3 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 1.22914186966801e-14 5.46584025167994e-13 1.34609091340001 0.776470588235294 11.3 11 3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 1.22914186966801e-14 5.46584025167994e-13 1.34609091340001 0.776470588235294 11.3 11 3 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 8.26613560108892e-12 1.33667170003972e-10 1.34548209797106 0.776119402985075 11.3 11 3 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 2.16375865637871e-10 2.79911688002446e-09 1.34503598321709 0.775862068965517 11.3 11 3 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 2.16375865637871e-10 2.79911688002446e-09 1.34503598321709 0.775862068965517 11.3 11 3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 4.20125628690676e-06 2.53321512553742e-05 1.34214343271555 0.774193548387097 11.3 11 3 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.00011951272457226 0.000458400558130259 1.33960149439601 0.772727272727273 11.3 11 3 KINESINS%REACTOME%REACT_199117.2 KINESINS 0.00011951272457226 0.000458400558130259 1.33960149439601 0.772727272727273 11.3 11 3 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 3.25781950073213e-05 0.000145782300300057 1.3335399491725 0.769230769230769 11.3 11 3 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 3.25781950073213e-05 0.000145782300300057 1.3335399491725 0.769230769230769 11.3 11 3 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605932 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%REACT_196637.2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY 0.00366697413958651 0.0096452942710381 1.3335399491725 0.769230769230769 11.3 11 3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 2.58832038298346e-08 2.16657641469733e-07 1.32786531109092 0.765957446808511 11.3 11 3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 7.3123162523012e-09 6.62765988982459e-08 1.32569559653031 0.764705882352941 11.3 11 3 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 2.48575662040648e-06 1.60783257765383e-05 1.32569559653031 0.764705882352941 11.3 11 3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.000956094946746163 0.00303011828334029 1.32569559653031 0.764705882352941 11.3 11 3 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 6.4456238663526e-12 1.05426698411721e-10 1.32427925508103 0.763888888888889 11.3 11 3 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 5.87489890123898e-15 2.98570754873681e-13 1.32350255170561 0.763440860215054 11.3 11 3 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 6.93061132745214e-07 4.88230689057643e-06 1.32301200220535 0.763157894736842 11.3 11 3 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.000255193153346065 0.000896641622744322 1.32083956870419 0.761904761904762 11.3 11 3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.45703367027504e-08 4.43734795017222e-07 1.31904494972498 0.760869565217391 11.3 11 3 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 3.86275448432554e-12 8.86564456644394e-11 1.31753746978243 0.76 11.3 11 3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 6.91795916047482e-05 0.000282247438061564 1.31753746978243 0.76 11.3 11 3 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 1.89615834908268e-05 9.15345648300542e-05 1.31514629470116 0.758620689655172 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 4.07338986418236e-07 2.94235217092969e-06 1.31077219394273 0.75609756097561 11.3 11 3 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 1.14319911724184e-07 9.13917047098391e-07 1.30983257229833 0.755555555555556 11.3 11 3 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 1.36821238845747e-12 3.74416582456727e-11 1.30555207369604 0.753086419753086 11.3 11 3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 1.36821238845747e-12 3.74416582456727e-11 1.30555207369604 0.753086419753086 11.3 11 3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.000145274698518457 0.000538348687478553 1.30020145044319 0.75 11.3 11 3 REGULATION OF SIGNALING BY CBL%REACTOME%REACT_198634.2 REGULATION OF SIGNALING BY CBL 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 SIGNALING BY NOTCH4%REACTOME%REACT_199404.2 SIGNALING BY NOTCH4 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.00783834772789007 0.0183453434486638 1.30020145044319 0.75 11.3 11 3 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 5.34158846646482e-09 5.3908371544535e-08 1.30020145044319 0.75 11.3 11 3 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 2.37890870353791e-07 1.79110427784892e-06 1.30020145044319 0.75 11.3 11 3 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER%REACTOME%REACT_219381.1 REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE%REACTOME%REACT_209299.1 REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.00202649892317437 0.00577897388312049 1.30020145044319 0.75 11.3 11 3 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 48%5604742 RECYCLING OF EIF2:GDP 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%REACT_198990.2 THE ACTIVATION OF ARYLSULFATASES 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 48%5605654 TYPE I HEMIDESMOSOME ASSEMBLY 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604889 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 WNT MEDIATED ACTIVATION OF DVL%REACTOME%REACT_225118.1 WNT MEDIATED ACTIVATION OF DVL 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605489 ORGANIC ANION TRANSPORTERS 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605588 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605589 FREE FATTY ACIDS REGULATE INSULIN SECRETION 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT)%REACTOME DATABASE ID RELEASE 48%5604655 PENTOSE PHOSPHATE PATHWAY (HEXOSE MONOPHOSPHATE SHUNT) 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%REACT_199100.2 DOWNREGULATION OF ERBB4 SIGNALING 0.0317409651121898 0.0617040892823033 1.30020145044319 0.75 11.3 11 3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 5.84604988979245e-12 1.05426698411721e-10 1.29471536837381 0.746835443037975 11.3 11 3 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 5.84604988979245e-12 1.05426698411721e-10 1.29471536837381 0.746835443037975 11.3 11 3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 5.84604988979245e-12 1.05426698411721e-10 1.29471536837381 0.746835443037975 11.3 11 3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7.18493568814013e-11 9.9960213326231e-10 1.29409721828149 0.746478873239437 11.3 11 3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 8.87286741435476e-10 1.07000765513787e-08 1.29332207768952 0.746031746031746 11.3 11 3 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 1.38241140915419e-07 1.09897845543375e-06 1.29098016356062 0.74468085106383 11.3 11 3 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 2.00828679035166e-12 5.2922075975378e-11 1.28490496279092 0.741176470588235 11.3 11 3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 2.26322147926979e-08 1.91700247916721e-07 1.28414958068463 0.740740740740741 11.3 11 3 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 8.2272342728664e-05 0.00032611014959022 1.28414958068463 0.740740740740741 11.3 11 3 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.000301388479949996 0.00105634435214001 1.28135795116141 0.739130434782609 11.3 11 3 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 5.31346216851458e-18 3.78052833289813e-16 1.2801983512056 0.738461538461539 11.3 11 3 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 3.95844942124082e-28 6.25874836269521e-26 1.27956333218219 0.738095238095238 11.3 11 3 SIGNALING BY LEPTIN%REACTOME%REACT_188529.2 SIGNALING BY LEPTIN 0.0011179638399046 0.00351183784588133 1.27739089868103 0.736842105263158 11.3 11 3 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 5.478225622586e-15 2.8872278003481e-13 1.27236839187101 0.73394495412844 11.3 11 3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.00422195367956968 0.0110033701209298 1.27130808487779 0.733333333333333 11.3 11 3 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 3.84311615985733e-14 1.49005969393593e-12 1.26686295171388 0.730769230769231 11.3 11 3 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.000168526239512048 0.000613332068607788 1.26686295171388 0.730769230769231 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 7.31342109176627e-06 4.12976119586643e-05 1.26506087070148 0.72972972972973 11.3 11 3 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 7.31342109176627e-06 4.12976119586643e-05 1.26506087070148 0.72972972972973 11.3 11 3 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 1.5256872247542e-08 1.33193430725474e-07 1.2634725959109 0.728813559322034 11.3 11 3 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 1.5256872247542e-08 1.33193430725474e-07 1.2634725959109 0.728813559322034 11.3 11 3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 2.61748192612972e-05 0.000118620279645943 1.26080140649037 0.727272727272727 11.3 11 3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.000617007630076213 0.00206588672376106 1.26080140649037 0.727272727272727 11.3 11 3 SIGNALING BY FGFR3 MUTANTS%REACTOME%REACT_196505.2 SIGNALING BY FGFR3 MUTANTS 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 NICD TRAFFICS TO NUCLEUS%REACTOME DATABASE ID RELEASE 48%5605101 NICD TRAFFICS TO NUCLEUS 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_215603.1 FGFR3 LIGAND BINDING AND ACTIVATION 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_220750.1 FGFR3C LIGAND BINDING AND ACTIVATION 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%REACT_196507.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%REACT_223683.1 NOTCH-HLH TRANSCRIPTION PATHWAY 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%REACT_196632.2 CONDENSATION OF PROMETAPHASE CHROMOSOMES 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604714 PURINE CATABOLISM 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.0163929934176911 0.0352375069990551 1.26080140649037 0.727272727272727 11.3 11 3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 8.74570841755309e-09 7.82713401143273e-08 1.25825946817083 0.725806451612903 11.3 11 3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605556 POST-CHAPERONIN TUBULIN FOLDING PATHWAY 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.00228682172585294 0.00636819435594664 1.25204584116752 0.722222222222222 11.3 11 3 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 2.86164442883e-09 3.08493941077658e-08 1.24921315826895 0.720588235294118 11.3 11 3 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 5.26073019009892e-05 0.000223463255537635 1.24602639000806 0.71875 11.3 11 3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 5.26073019009892e-05 0.000223463255537635 1.24602639000806 0.71875 11.3 11 3 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 8.2885359133738e-06 4.400965151019e-05 1.24463728589434 0.717948717948718 11.3 11 3 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 4.43847955785495e-11 6.25342218893822e-10 1.24411432905152 0.717647058823529 11.3 11 3 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 1.32427415011674e-06 8.88887790384961e-06 1.24367095259783 0.717391304347826 11.3 11 3 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 1.32427415011674e-06 8.88887790384961e-06 1.24367095259783 0.717391304347826 11.3 11 3 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 5.6784373715929e-09 5.65064082501867e-08 1.24198347505021 0.716417910447761 11.3 11 3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 5.6784373715929e-09 5.65064082501867e-08 1.24198347505021 0.716417910447761 11.3 11 3 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.48054786705952e-07 5.19259493406132e-06 1.23828709566018 0.714285714285714 11.3 11 3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 2.93977386226099e-05 0.000132382854620171 1.23828709566018 0.714285714285714 11.3 11 3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.000188686055395562 0.000681472733065698 1.23828709566018 0.714285714285714 11.3 11 3 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.000188686055395562 0.000681472733065698 1.23828709566018 0.714285714285714 11.3 11 3 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.000188686055395562 0.000681472733065698 1.23828709566018 0.714285714285714 11.3 11 3 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.00124483383140837 0.00386258816867753 1.23828709566018 0.714285714285714 11.3 11 3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.00124483383140837 0.00386258816867753 1.23828709566018 0.714285714285714 11.3 11 3 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.00862465490903582 0.0199235128823993 1.23828709566018 0.714285714285714 11.3 11 3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.00862465490903582 0.0199235128823993 1.23828709566018 0.714285714285714 11.3 11 3 MICRORNA (MIRNA) BIOGENESIS%REACTOME%REACT_221178.1 MICRORNA (MIRNA) BIOGENESIS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 48%5605620 NECTIN NECL TRANS HETERODIMERIZATION 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5605558 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%REACT_223195.1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9) 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%REACT_215258.1 VITAMIN C (ASCORBATE) METABOLISM 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605514 NRCAM INTERACTIONS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 48%5604740 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%REACT_218211.1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 0.0668269103374056 0.109430026939158 1.23828709566018 0.714285714285714 11.3 11 3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 3.02788487495592e-10 3.88169385320926e-09 1.23519137792103 0.7125 11.3 11 3 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 1.83862342253602e-09 2.09308890421501e-08 1.23489452827481 0.712328767123288 11.3 11 3 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 1.6434904025829e-05 8.12804888928127e-05 1.23176979515671 0.710526315789474 11.3 11 3 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 6.35857439157455e-09 5.80016112769909e-08 1.23110861974331 0.710144927536232 11.3 11 3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 9.19280893553633e-06 4.84495078343267e-05 1.22620624594642 0.707317073170732 11.3 11 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 9.19280893553633e-06 4.84495078343267e-05 1.22620624594642 0.707317073170732 11.3 11 3 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 2.04526068039568e-09 2.29165822693154e-08 1.22507869997314 0.706666666666667 11.3 11 3 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 5.80559451091906e-05 0.000244022767409937 1.22371901218183 0.705882352941177 11.3 11 3 CHYLOMICRON-MEDIATED LIPID TRANSPORT%REACTOME%REACT_216017.1 CHYLOMICRON-MEDIATED LIPID TRANSPORT 0.00459546846660206 0.0117403081292185 1.22371901218183 0.705882352941177 11.3 11 3 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.00459546846660206 0.0117403081292185 1.22371901218183 0.705882352941177 11.3 11 3 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.00459546846660206 0.0117403081292185 1.22371901218183 0.705882352941177 11.3 11 3 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 1.15942231021754e-09 1.38643524994921e-08 1.22241162007479 0.705128205128205 11.3 11 3 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 5.14489252138508e-06 3.0632560911845e-05 1.22140136253754 0.704545454545455 11.3 11 3 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 5.14489252138508e-06 3.0632560911845e-05 1.22140136253754 0.704545454545455 11.3 11 3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.000373379244372586 0.00127414547899806 1.2199421016504 0.703703703703704 11.3 11 3 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 5.22194003497739e-14 1.90533863327508e-12 1.21781954036001 0.702479338842975 11.3 11 3 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 5.22194003497739e-14 1.90533863327508e-12 1.21781954036001 0.702479338842975 11.3 11 3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 1.47598633254304e-07 1.12317034823997e-06 1.21352135374698 0.7 11.3 11 3 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 1.79638656490601e-05 8.8451836742604e-05 1.21352135374698 0.7 11.3 11 3 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00247133498983297 0.00677593389312585 1.21352135374698 0.7 11.3 11 3 INTERLEUKIN-6 SIGNALING%REACTOME%REACT_199118.2 INTERLEUKIN-6 SIGNALING 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605646 GP1B-IX-V ACTIVATION SIGNALLING 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%REACT_210229.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 REGULATION OF THE FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605615 REGULATION OF THE FANCONI ANEMIA PATHWAY 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%REACT_205688.1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%REACT_219627.1 BASE-FREE SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%REACT_196554.2 HYALURONAN UPTAKE AND DEGRADATION 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198546.2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 REGULATORY RNA PATHWAYS%REACTOME%REACT_206535.1 REGULATORY RNA PATHWAYS 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 IRAK1 RECRUITS IKK COMPLEX%REACTOME%REACT_198543.2 IRAK1 RECRUITS IKK COMPLEX 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 48%5605608 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 0.0334043440016832 0.0625639780400896 1.21352135374698 0.7 11.3 11 3 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 1.75796528749517e-15 1.00063384164225e-13 1.20977976683923 0.697841726618705 11.3 11 3 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 8.99690413817427e-20 8.00162161788874e-18 1.20598395403426 0.695652173913043 11.3 11 3 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00133842283036472 0.00406092897144775 1.20598395403426 0.695652173913043 11.3 11 3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 1.38604030380861e-09 1.61666832157348e-08 1.20506475894735 0.695121951219512 11.3 11 3 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 7.36458619681171e-11 9.9960213326231e-10 1.20439713304211 0.694736842105263 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 6.27247744642146e-05 0.000261751771444508 1.20389023189184 0.694444444444444 11.3 11 3 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 6.27247744642146e-05 0.000261751771444508 1.20389023189184 0.694444444444444 11.3 11 3 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604817 SOS-MEDIATED SIGNALLING 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 HYALURONAN METABOLISM%REACTOME%REACT_196551.2 HYALURONAN METABOLISM 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605648 CELL-EXTRACELLULAR MATRIX INTERACTIONS 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604918 GRB2 EVENTS IN EGFR SIGNALING 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%REACT_202555.1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION 0.0172239383015731 0.0362033444654926 1.20018595425525 0.692307692307692 11.3 11 3 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 2.65399136939962e-09 2.90509978358127e-08 1.19853960863899 0.691358024691358 11.3 11 3 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 2.28934871791838e-13 7.40396187635877e-12 1.19801759661432 0.691056910569106 11.3 11 3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 1.93016499774497e-05 9.24319716394344e-05 1.19701085913818 0.69047619047619 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.000398736839916846 0.00135742230431022 1.19558754063742 0.689655172413793 11.3 11 3 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 4.75693473662407e-10 5.93782292124216e-09 1.19425911003671 0.688888888888889 11.3 11 3 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 1.07333360823406e-05 5.61527104601866e-05 1.19425911003671 0.688888888888889 11.3 11 3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 5.9769217387285e-06 3.50006569309081e-05 1.19185132957293 0.6875 11.3 11 3 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.00905195414363942 0.0207088918752394 1.19185132957293 0.6875 11.3 11 3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 2.84584438439297e-09 3.08493941077658e-08 1.19054590642991 0.686746987951807 11.3 11 3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 1.60253022289636e-09 1.83903266708187e-08 1.18933155932013 0.686046511627907 11.3 11 3 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 8.25631686135555e-13 2.38933175629112e-11 1.18916496293978 0.685950413223141 11.3 11 3 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 4.66557632061276e-13 1.41257768175148e-11 1.18835616438356 0.685483870967742 11.3 11 3 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 2.63659622207938e-13 8.33750316448658e-12 1.18758557678276 0.68503937007874 11.3 11 3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 3.03285564139741e-08 2.50915905680727e-07 1.18739858487963 0.684931506849315 11.3 11 3 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 1.7039101877721e-08 1.47845377878031e-07 1.18614869163238 0.684210526315789 11.3 11 3 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.00481934714540766 0.0120103870191158 1.18614869163238 0.684210526315789 11.3 11 3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.00481934714540766 0.0120103870191158 1.18614869163238 0.684210526315789 11.3 11 3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.5899197225734e-18 1.93971356064313e-16 1.18415432645099 0.683060109289617 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 3.68553724166501e-05 0.000162369024609576 1.18392327194827 0.682926829268293 11.3 11 3 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 3.68553724166501e-05 0.000162369024609576 1.18392327194827 0.682926829268293 11.3 11 3 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 3.68553724166501e-05 0.000162369024609576 1.18392327194827 0.682926829268293 11.3 11 3 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 3.25275520132521e-07 2.43614244815041e-06 1.18325211363084 0.682539682539683 11.3 11 3 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 3.02898307570934e-09 3.21659919159283e-08 1.18292837844243 0.682352941176471 11.3 11 3 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 3.02898307570934e-09 3.21659919159283e-08 1.18292837844243 0.682352941176471 11.3 11 3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 2.89593521371084e-11 4.33780611485318e-10 1.1827377680044 0.682242990654206 11.3 11 3 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.00259017569140584 0.00706095787139944 1.18200131858472 0.681818181818182 11.3 11 3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.00259017569140584 0.00706095787139944 1.18200131858472 0.681818181818182 11.3 11 3 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.00259017569140584 0.00706095787139944 1.18200131858472 0.681818181818182 11.3 11 3 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 1.13539848429971e-05 5.91821261230213e-05 1.18032472096971 0.680851063829787 11.3 11 3 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 1.71349808333098e-10 2.27879231082241e-09 1.17884931506849 0.68 11.3 11 3 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.00140211695107788 0.00423611979062384 1.17884931506849 0.68 11.3 11 3 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.00140211695107788 0.00423611979062384 1.17884931506849 0.68 11.3 11 3 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 3.51914904451149e-06 2.17728221319124e-05 1.17754093625044 0.679245283018868 11.3 11 3 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 3.06709856594394e-11 4.54633464514399e-10 1.17694076248069 0.678899082568807 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 1.7292073160966e-11 2.67463262044072e-10 1.17637274087717 0.678571428571429 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.000763287087768528 0.00250938629483473 1.17637274087717 0.678571428571429 11.3 11 3 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.000763287087768528 0.00250938629483473 1.17637274087717 0.678571428571429 11.3 11 3 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 6.12565644037514e-07 4.35840455732691e-06 1.17437550362611 0.67741935483871 11.3 11 3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.000229125606322376 0.000819210396474225 1.17273072000758 0.676470588235294 11.3 11 3 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.000126165926350017 0.000473704784158507 1.17135265805693 0.675675675675676 11.3 11 3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 6.96573014330394e-05 0.000282247438061564 1.17018130539887 0.675 11.3 11 3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 6.96573014330394e-05 0.000282247438061564 1.17018130539887 0.675 11.3 11 3 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 3.85463986264828e-05 0.000168773923832262 1.16917339729775 0.674418604651163 11.3 11 3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 2.13728062462074e-05 0.00010137834429451 1.16829695547069 0.673913043478261 11.3 11 3 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 5.98387397499527e-10 7.34056264346403e-09 1.16752783305103 0.673469387755102 11.3 11 3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 1.18711200299644e-05 6.1205086241447e-05 1.16752783305103 0.673469387755102 11.3 11 3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 6.06657097733174e-12 1.05426698411721e-10 1.16520785722778 0.672131147540984 11.3 11 3 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 7.14618227004676e-20 6.77934491351769e-18 1.15836129221302 0.668181818181818 11.3 11 3 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00078521603010058 0.00256430440076041 1.15573462261617 0.666666666666667 11.3 11 3 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.00078521603010058 0.00256430440076041 1.15573462261617 0.666666666666667 11.3 11 3 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 48%5604660 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS) 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.0174300573679681 0.0364213974076632 1.15573462261617 0.666666666666667 11.3 11 3 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 2.25339226077176e-17 1.39416399438183e-15 1.15573462261617 0.666666666666667 11.3 11 3 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 2.05632507722123e-08 1.76274131619627e-07 1.15573462261617 0.666666666666667 11.3 11 3 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 2.05632507722123e-08 1.76274131619627e-07 1.15573462261617 0.666666666666667 11.3 11 3 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 2.21081110515345e-05 0.000104517747595792 1.15573462261617 0.666666666666667 11.3 11 3 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.000236299274311306 0.000842741522167891 1.15573462261617 0.666666666666667 11.3 11 3 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.000429997776915704 0.00145687342035963 1.15573462261617 0.666666666666667 11.3 11 3 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.00143993074272573 0.00429564244632853 1.15573462261617 0.666666666666667 11.3 11 3 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00265422459281239 0.00720414572324974 1.15573462261617 0.666666666666667 11.3 11 3 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00265422459281239 0.00720414572324974 1.15573462261617 0.666666666666667 11.3 11 3 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.0049243373066822 0.0122078954484473 1.15573462261617 0.666666666666667 11.3 11 3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.0049243373066822 0.0122078954484473 1.15573462261617 0.666666666666667 11.3 11 3 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0049243373066822 0.0122078954484473 1.15573462261617 0.666666666666667 11.3 11 3 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.00921276194810029 0.0209421090289884 1.15573462261617 0.666666666666667 11.3 11 3 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.00921276194810029 0.0209421090289884 1.15573462261617 0.666666666666667 11.3 11 3 SIGNALING BY NOTCH3%REACTOME%REACT_199413.2 SIGNALING BY NOTCH3 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 ATTENUATION PHASE%REACTOME%REACT_223784.1 ATTENUATION PHASE 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206694.1 FGFR4 LIGAND BINDING AND ACTIVATION 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%REACT_188623.2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX) 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_206745.1 FGFR2C LIGAND BINDING AND ACTIVATION 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0335022847972933 0.0625639780400896 1.15573462261617 0.666666666666667 11.3 11 3 ENOS ACTIVATION%REACTOME%REACT_221264.1 ENOS ACTIVATION 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%REACT_211477.1 APOPTOTIC FACTOR-MEDIATED RESPONSE 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196593.2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%REACT_199053.2 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605623 BICARBONATE TRANSPORTERS 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%REACT_196636.2 TRIF-MEDIATED PROGRAMMED CELL DEATH 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604640 G2 M DNA DAMAGE CHECKPOINT 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605559 FOLDING OF ACTIN BY CCT TRIC 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1%REACTOME%REACT_220827.1 DISPLACEMENT OF DNA GLYCOSYLASE BY APE1 0.0659620722017682 0.10914421946874 1.15573462261617 0.666666666666667 11.3 11 3 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 3.80255818793179e-11 5.46569727416863e-10 1.15087859479005 0.663865546218487 11.3 11 3 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 2.12664584633495e-10 2.79911688002446e-09 1.15048128342246 0.663636363636364 11.3 11 3 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 2.12246906901104e-08 1.80854699712737e-07 1.14901523527538 0.662790697674419 11.3 11 3 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 1.07174025325864e-35 3.05017276077408e-33 1.14759564640056 0.661971830985915 11.3 11 3 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.96281965710621e-12 8.9509402731145e-11 1.14704488861154 0.661654135338346 11.3 11 3 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 2.17929639392856e-09 2.42276466293777e-08 1.14417727639001 0.66 11.3 11 3 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 4.84911975954444e-19 4.05899848107749e-17 1.14277795644334 0.659192825112108 11.3 11 3 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.000132918164536076 0.000493844773198007 1.14164029795012 0.658536585365854 11.3 11 3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000132918164536076 0.000493844773198007 1.14164029795012 0.658536585365854 11.3 11 3 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 9.71630791254655e-23 1.25693692359579e-20 1.14086303739868 0.658088235294118 11.3 11 3 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.000240737048405889 0.000856422049703951 1.14052758810806 0.657894736842105 11.3 11 3 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.29940895444258e-42 6.1635298072393e-40 1.14035412383611 0.657794676806084 11.3 11 3 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.000437165714703769 0.00147364980970131 1.13922412800737 0.657142857142857 11.3 11 3 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.000796331284251695 0.00258716761984055 1.13767626913779 0.65625 11.3 11 3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 3.99294035727086e-06 2.44911815879157e-05 1.13678815339295 0.655737704918033 11.3 11 3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.00267375574996555 0.00723337344524901 1.13350895679663 0.653846153846154 11.3 11 3 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 7.44608757033063e-11 9.9960213326231e-10 1.13243352135375 0.653225806451613 11.3 11 3 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 7.44608757033063e-11 9.9960213326231e-10 1.13243352135375 0.653225806451613 11.3 11 3 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 7.44608757033063e-11 9.9960213326231e-10 1.13243352135375 0.653225806451613 11.3 11 3 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 7.10559132323091e-07 4.9809145088461e-06 1.13165681797833 0.652777777777778 11.3 11 3 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 1.26795467491784e-06 8.62718256457746e-06 1.13060995690712 0.652173913043478 11.3 11 3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 1.26795467491784e-06 8.62718256457746e-06 1.13060995690712 0.652173913043478 11.3 11 3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 7.23707592498921e-06 4.12976119586643e-05 1.12684125705077 0.65 11.3 11 3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000242746051867736 0.0008614155406678 1.12684125705077 0.65 11.3 11 3 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0091799411486178 0.0209343850232101 1.12684125705077 0.65 11.3 11 3 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0091799411486178 0.0209343850232101 1.12684125705077 0.65 11.3 11 3 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 2.34093371561378e-09 2.58228579637086e-08 1.12363088309905 0.648148148148148 11.3 11 3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 2.32190794736625e-05 0.000107976307486999 1.12363088309905 0.648148148148148 11.3 11 3 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 1.39934918954083e-11 2.18898816871731e-10 1.12247607232506 0.647482014388489 11.3 11 3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%REACT_198970.2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%REACT_220322.1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS) 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0172221778848746 0.0362033444654926 1.12174242783334 0.647058823529412 11.3 11 3 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.00145394649773853 0.00432838047339315 1.11845286059629 0.645161290322581 11.3 11 3 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 4.18295065113268e-09 4.25167055468701e-08 1.11793021907265 0.644859813084112 11.3 11 3 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.00265788932164871 0.00720414572324974 1.11445838609416 0.642857142857143 11.3 11 3 EXTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604707 EXTRINSIC PATHWAY FOR APOPTOSIS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 DEATH RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604706 DEATH RECEPTOR SIGNALLING 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME%REACT_225463.1 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0327026484081401 0.0625639780400896 1.11445838609416 0.642857142857143 11.3 11 3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 4.08440894594018e-06 2.47323997024378e-05 1.11261019639915 0.641791044776119 11.3 11 3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 4.08440894594018e-06 2.47323997024378e-05 1.11261019639915 0.641791044776119 11.3 11 3 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 2.69902906220861e-13 8.3493877293975e-12 1.11154476939849 0.641176470588235 11.3 11 3 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.000438056127550004 0.00147364980970131 1.11128329097709 0.641025641025641 11.3 11 3 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 7.28118085719558e-06 4.12976119586643e-05 1.11058873892023 0.640625 11.3 11 3 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 8.39540321957525e-13 2.38933175629112e-11 1.1099280674515 0.640243902439024 11.3 11 3 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 7.46663393829403e-05 0.000296788270787497 1.10950523771152 0.64 11.3 11 3 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 1.29880435223081e-05 6.55389572065403e-05 1.10836844955813 0.639344262295082 11.3 11 3 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 1.29880435223081e-05 6.55389572065403e-05 1.10836844955813 0.639344262295082 11.3 11 3 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 4.76823136463407e-13 1.41358192330714e-11 1.10786395777408 0.63905325443787 11.3 11 3 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 2.28987275718559e-06 1.49471969425463e-05 1.1075790133405 0.638888888888889 11.3 11 3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.000792544801551969 0.00258075801512231 1.1075790133405 0.638888888888889 11.3 11 3 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 2.08108963556843e-21 2.11527896529563e-19 1.10642853803357 0.638225255972696 11.3 11 3 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 1.48105687719896e-12 3.97649799293231e-11 1.10610184741179 0.638036809815951 11.3 11 3 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 2.31834917255449e-05 0.000107976307486999 1.10591847508961 0.637931034482759 11.3 11 3 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 2.31834917255449e-05 0.000107976307486999 1.10591847508961 0.637931034482759 11.3 11 3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 4.07283018680718e-06 2.47323997024378e-05 1.10548529119808 0.63768115942029 11.3 11 3 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 2.60980630527274e-12 6.75228067709655e-11 1.10517123287671 0.6375 11.3 11 3 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 7.42410690469586e-09 6.68639501606469e-08 1.10320123067907 0.636363636363636 11.3 11 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 4.14127070245156e-05 0.000178037106029866 1.10320123067907 0.636363636363636 11.3 11 3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 4.14127070245156e-05 0.000178037106029866 1.10320123067907 0.636363636363636 11.3 11 3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 4.11410455532694e-08 3.38402935389031e-07 1.10320123067907 0.636363636363636 11.3 11 3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.0090091201334158 0.0207088918752394 1.10320123067907 0.636363636363636 11.3 11 3 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604604 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%REACT_207835.1 G-PROTEIN BETA:GAMMA SIGNALLING 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 CASPASE-8 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604769 CASPASE-8 ACTIVATION 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%REACT_196538.2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 48%5604768 DIMERIZATION OF PROCASPASE-8 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 REGULATION BY C-FLIP%REACTOME%REACT_215122.1 REGULATION BY C-FLIP 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%REACT_220918.1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%REACT_225874.1 FGFR1C LIGAND BINDING AND ACTIVATION 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605528 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 UNWINDING OF DNA%REACTOME%REACT_217374.1 UNWINDING OF DNA 0.0631742075236693 0.106135696490353 1.10320123067907 0.636363636363636 11.3 11 3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 1.29013709812048e-05 6.55389572065403e-05 1.10069964058683 0.634920634920635 11.3 11 3 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 2.31588631573798e-08 1.95000368479003e-07 1.10017045806732 0.634615384615385 11.3 11 3 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 7.40350591193872e-05 0.000295103330887641 1.10017045806732 0.634615384615385 11.3 11 3 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 7.40350591193872e-05 0.000295103330887641 1.10017045806732 0.634615384615385 11.3 11 3 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 1.33821397925446e-09 1.5737838780819e-08 1.09935732395197 0.634146341463415 11.3 11 3 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 7.18629619567462e-07 5.01279386590441e-06 1.09935732395197 0.634146341463415 11.3 11 3 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 1.52366808930656e-13 5.28824314898349e-12 1.09889521494652 0.633879781420765 11.3 11 3 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 4.28299981708e-10 5.39354755726092e-09 1.09838901157033 0.633587786259542 11.3 11 3 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 4.28299981708e-10 5.39354755726092e-09 1.09838901157033 0.633587786259542 11.3 11 3 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 2.29783276802114e-05 0.000107914720425547 1.09794789148536 0.633333333333333 11.3 11 3 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 1.27316116553849e-06 8.62718256457746e-06 1.09721641387611 0.632911392405063 11.3 11 3 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 4.02400990876232e-07 2.94235217092969e-06 1.0959552455843 0.632183908045977 11.3 11 3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 4.02400990876232e-07 2.94235217092969e-06 1.0959552455843 0.632183908045977 11.3 11 3 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 2.48218354995961e-11 3.7576033953112e-10 1.09490648458374 0.631578947368421 11.3 11 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0167443301812876 0.0358843100120065 1.09490648458374 0.631578947368421 11.3 11 3 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.0167443301812876 0.0358843100120065 1.09490648458374 0.631578947368421 11.3 11 3 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.39984485842077e-11 2.18898816871731e-10 1.09316300292039 0.630573248407643 11.3 11 3 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 7.30104632121388e-05 0.000292658842678517 1.09152714358194 0.62962962962963 11.3 11 3 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.00477125826227321 0.0119323383255093 1.09152714358194 0.62962962962963 11.3 11 3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.00477125826227321 0.0119323383255093 1.09152714358194 0.62962962962963 11.3 11 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00477125826227321 0.0119323383255093 1.09152714358194 0.62962962962963 11.3 11 3 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.38573654577763e-11 2.18898816871731e-10 1.09031568171337 0.628930817610063 11.3 11 3 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 8.67866477407992e-15 4.25853102535025e-13 1.08969264418096 0.628571428571429 11.3 11 3 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 7.08574121517432e-06 4.06572973757784e-05 1.08969264418096 0.628571428571429 11.3 11 3 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.00140935185243373 0.00423997396620126 1.08969264418096 0.628571428571429 11.3 11 3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.00140935185243373 0.00423997396620126 1.08969264418096 0.628571428571429 11.3 11 3 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 2.43282294594441e-11 3.7224807011601e-10 1.08905762515754 0.628205128205128 11.3 11 3 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 4.02953585046986e-05 0.000174286611404821 1.08717409415589 0.627118644067797 11.3 11 3 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 4.21247068006279e-11 5.99434577772934e-10 1.0848992747784 0.625806451612903 11.3 11 3 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 6.96576317029336e-06 4.01306922725808e-05 1.08350120870266 0.625 11.3 11 3 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 6.96576317029336e-06 4.01306922725808e-05 1.08350120870266 0.625 11.3 11 3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 2.22683545212203e-05 0.000104926716833432 1.08350120870266 0.625 11.3 11 3 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 7.16524130652853e-05 0.000288026507886726 1.08350120870266 0.625 11.3 11 3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.000763572920353786 0.00250938629483473 1.08350120870266 0.625 11.3 11 3 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.0313935627418492 0.0617040892823033 1.08350120870266 0.625 11.3 11 3 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.0313935627418492 0.0617040892823033 1.08350120870266 0.625 11.3 11 3 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0313935627418492 0.0617040892823033 1.08350120870266 0.625 11.3 11 3 ACTIVATION OF DNA FRAGMENTATION FACTOR%REACTOME%REACT_205002.1 ACTIVATION OF DNA FRAGMENTATION FACTOR 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%REACT_208718.1 DEPOLYMERISATION OF THE NUCLEAR LAMINA 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 INITIATION OF NUCLEAR ENVELOPE REFORMATION%REACTOME%REACT_210180.1 INITIATION OF NUCLEAR ENVELOPE REFORMATION 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%REACT_203657.1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION) 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%REACT_210016.1 BASE-EXCISION REPAIR, AP SITE FORMATION 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605574 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 RETINOID CYCLE DISEASE EVENTS%REACTOME%REACT_196615.2 RETINOID CYCLE DISEASE EVENTS 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR%REACTOME DATABASE ID RELEASE 48%5605096 RECEPTOR-LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 NUCLEAR ENVELOPE REASSEMBLY%REACTOME%REACT_208002.1 NUCLEAR ENVELOPE REASSEMBLY 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%REACT_215449.1 APOPTOSIS INDUCED DNA FRAGMENTATION 0.125303485712766 0.19152186913992 1.08350120870266 0.625 11.3 11 3 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 1.61321443190953e-17 1.09314482695584e-15 1.08267093957722 0.624521072796935 11.3 11 3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.000127453357694653 0.000476026582675829 1.07941252489623 0.622641509433962 11.3 11 3 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.000127453357694653 0.000476026582675829 1.07941252489623 0.622641509433962 11.3 11 3 MEIOTIC RECOMBINATION%REACTOME%REACT_198629.2 MEIOTIC RECOMBINATION 0.00041541563226193 0.00141082683701367 1.07868564777509 0.622222222222222 11.3 11 3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 3.88257277208829e-09 4.0396643227512e-08 1.07838230535446 0.622047244094488 11.3 11 3 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 6.95472892420175e-10 8.45861475140094e-09 1.07730977322436 0.621428571428571 11.3 11 3 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 7.00164059281321e-05 0.000282247438061564 1.07602878657368 0.620689655172414 11.3 11 3 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 7.00164059281321e-05 0.000282247438061564 1.07602878657368 0.620689655172414 11.3 11 3 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 7.00164059281321e-05 0.000282247438061564 1.07602878657368 0.620689655172414 11.3 11 3 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 3.78358721099641e-06 2.33075523863545e-05 1.07527208559859 0.620253164556962 11.3 11 3 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 3.80615599391165e-09 4.0119703550639e-08 1.07510197452667 0.62015503875969 11.3 11 3 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.000226785528147056 0.000817002041906989 1.07483319903304 0.62 11.3 11 3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 1.20437419683307e-05 6.14274007918804e-05 1.0743448604601 0.619718309859155 11.3 11 3 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.63877315311043e-07 4.69998716262495e-06 1.07407945906177 0.619565217391304 11.3 11 3 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.000742638865460742 0.00246334523438377 1.07318214957216 0.619047619047619 11.3 11 3 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 6.66456899458371e-06 3.88675478659534e-05 1.07209593282158 0.618421052631579 11.3 11 3 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.000124168735134959 0.000470232452327327 1.07168119551681 0.618181818181818 11.3 11 3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 1.17356739782538e-05 6.07267784402004e-05 1.06865872639166 0.616438356164384 11.3 11 3 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 1.64308742223444e-52 1.16905670091981e-49 1.066831959338 0.615384615384615 11.3 11 3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.00841049450760679 0.0194920744044372 1.066831959338 0.615384615384615 11.3 11 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 REGULATION OF IFNG SIGNALING%REACTOME%REACT_198645.2 REGULATION OF IFNG SIGNALING 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%REACT_198647.2 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%REACT_199047.2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION 0.0595476391904454 0.103737479754988 1.066831959338 0.615384615384615 11.3 11 3 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 3.74874620009551e-05 0.000164644007491849 1.066831959338 0.615384615384615 11.3 11 3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 1.98205955260177e-09 2.23846884393041e-08 1.06492690226776 0.614285714285714 11.3 11 3 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 2.06580026769159e-05 9.83155110677304e-05 1.06492690226776 0.614285714285714 11.3 11 3 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 2.0914465879139e-13 7.08602022524163e-12 1.06492690226776 0.614285714285714 11.3 11 3 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 6.61086327507786e-05 0.000273466815128947 1.06253021756648 0.612903225806452 11.3 11 3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.00445189560471258 0.0114557819991067 1.06253021756648 0.612903225806452 11.3 11 3 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 1.08620560427799e-07 8.73260211800891e-07 1.06202640997162 0.612612612612613 11.3 11 3 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 3.48794093964326e-06 2.16739736118444e-05 1.06055647722425 0.611764705882353 11.3 11 3 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.00237862007524792 0.0066108913419488 1.05942340406482 0.611111111111111 11.3 11 3 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.0298084029283769 0.0590770993970479 1.05942340406482 0.611111111111111 11.3 11 3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0298084029283769 0.0590770993970479 1.05942340406482 0.611111111111111 11.3 11 3 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0298084029283769 0.0590770993970479 1.05942340406482 0.611111111111111 11.3 11 3 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 3.85593735784638e-89 5.4869988602154e-86 1.0587394638427 0.610716591349258 11.3 11 3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 1.07172190648902e-06 7.40320520841687e-06 1.05840960176428 0.610526315789474 11.3 11 3 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 5.94889438327965e-07 4.25390789316932e-06 1.0574971796938 0.61 11.3 11 3 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 1.04835327460983e-13 3.72951677442447e-12 1.05726395970268 0.609865470852018 11.3 11 3 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 6.14227443110459e-22 6.72342808881679e-20 1.0568482377934 0.609625668449198 11.3 11 3 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 3.30471457950766e-07 2.46209887258607e-06 1.05667165496336 0.60952380952381 11.3 11 3 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 6.39237566119021e-05 0.000265975162744844 1.05641367848509 0.609375 11.3 11 3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.0153431989762836 0.0335898032973101 1.05523595977998 0.608695652173913 11.3 11 3 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 3.51423503335678e-05 0.000156763525155696 1.05523595977998 0.608695652173913 11.3 11 3 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 1.93568008071338e-05 9.24319716394344e-05 1.05421739225124 0.608108108108108 11.3 11 3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 1.93568008071338e-05 9.24319716394344e-05 1.05421739225124 0.608108108108108 11.3 11 3 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 3.12358793618074e-15 1.70956370507123e-13 1.05375803826768 0.607843137254902 11.3 11 3 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 2.73141660049001e-32 6.47800970416214e-30 1.05351991431124 0.607705779334501 11.3 11 3 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.00803737389778385 0.0187494804205679 1.05254403131115 0.607142857142857 11.3 11 3 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.00803737389778385 0.0187494804205679 1.05254403131115 0.607142857142857 11.3 11 3 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 3.26471890086954e-06 2.07397098032918e-05 1.05184836440348 0.606741573033708 11.3 11 3 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.00426159790195029 0.0110116142573265 1.05066783874197 0.606060606060606 11.3 11 3 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00426159790195029 0.0110116142573265 1.05066783874197 0.606060606060606 11.3 11 3 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.00426159790195029 0.0110116142573265 1.05066783874197 0.606060606060606 11.3 11 3 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 1.71742934166608e-07 1.29994784744193e-06 1.04928538105942 0.605263157894737 11.3 11 3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 1.86667211224224e-05 9.09683019082435e-05 1.04928538105942 0.605263157894737 11.3 11 3 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.00227973773589944 0.00636819435594664 1.04928538105942 0.605263157894737 11.3 11 3 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 1.02996363126549e-05 5.4082592150952e-05 1.04872215755912 0.604938271604938 11.3 11 3 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 5.69122468892113e-06 3.34653418691519e-05 1.0482244251635 0.604651162790698 11.3 11 3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.00122784288037586 0.00384004487642825 1.0482244251635 0.604651162790698 11.3 11 3 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.00122784288037586 0.00384004487642825 1.0482244251635 0.604651162790698 11.3 11 3 DISEASE%REACTOME%REACT_189085.2 DISEASE 3.37962993529525e-42 1.20230334948129e-39 1.04548849024113 0.603072983354674 11.3 11 3 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 5.47804049819515e-06 3.23454424437e-05 1.04410116474984 0.602272727272727 11.3 11 3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.000636171072723085 0.00212007362174461 1.04016116035455 0.6 11.3 11 3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00764015476323568 0.0179999010398748 1.04016116035455 0.6 11.3 11 3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0145351889684908 0.0320786990145007 1.04016116035455 0.6 11.3 11 3 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.0145351889684908 0.0320786990145007 1.04016116035455 0.6 11.3 11 3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 48%5605584 SEMA3A PAK DEPENDENT AXON REPULSION 0.0556115349683982 0.0979396216089487 1.04016116035455 0.6 11.3 11 3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0556115349683982 0.0979396216089487 1.04016116035455 0.6 11.3 11 3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.00217611238597797 0.00619321585049332 1.04016116035455 0.6 11.3 11 3 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0280909137302924 0.0560636328726593 1.04016116035455 0.6 11.3 11 3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%REACT_198972.2 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 SUMOYLATION%REACTOME%REACT_196652.2 SUMOYLATION 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 PROCESSING AND ACTIVATION OF SUMO%REACTOME%REACT_196651.2 PROCESSING AND ACTIVATION OF SUMO 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 48%5604719 ETHANOL OXIDATION 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%REACT_220962.1 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 ATF6-ALPHA ACTIVATES CHAPERONE GENES%REACTOME%REACT_32838.4 ATF6-ALPHA ACTIVATES CHAPERONE GENES 0.114798664501896 0.177563586506736 1.04016116035455 0.6 11.3 11 3 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 3.87436462934853e-14 1.49005969393593e-12 1.03878528580382 0.599206349206349 11.3 11 3 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 3.87436462934853e-14 1.49005969393593e-12 1.03878528580382 0.599206349206349 11.3 11 3 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 3.87436462934853e-14 1.49005969393593e-12 1.03878528580382 0.599206349206349 11.3 11 3 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 4.56562014664962e-08 3.73383762567955e-07 1.0375344907577 0.598484848484849 11.3 11 3 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 5.44434523826169e-05 0.000230574502203761 1.03534559942699 0.597222222222222 11.3 11 3 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 2.67734227299428e-06 1.72391767170627e-05 1.03315670809627 0.595959595959596 11.3 11 3 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 4.83366819916982e-06 2.9022404419488e-05 1.03278413084849 0.595744680851064 11.3 11 3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 3.88920598887501e-09 4.0396643227512e-08 1.03138342904354 0.594936708860759 11.3 11 3 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 2.86548293553238e-05 0.000129447054516272 1.03138342904354 0.594936708860759 11.3 11 3 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.000315141664769788 0.00109644642779317 1.02840792690422 0.593220338983051 11.3 11 3 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0137039290462738 0.0305175133534391 1.02731966454771 0.592592592592593 11.3 11 3 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.0137039290462738 0.0305175133534391 1.02731966454771 0.592592592592593 11.3 11 3 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.00106259864214965 0.00335272254496441 1.02600930783272 0.591836734693878 11.3 11 3 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.00196327394870835 0.00564391682628684 1.02440114277342 0.590909090909091 11.3 11 3 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.0263308867649317 0.0533744328582591 1.02440114277342 0.590909090909091 11.3 11 3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 2.6061207348804e-05 0.000118482741397278 1.02345174412396 0.590361445783133 11.3 11 3 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00364701446551244 0.0096452942710381 1.02238062769892 0.58974358974359 11.3 11 3 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 6.00675636073938e-08 4.8565990348478e-07 1.02048908167172 0.588652482269504 11.3 11 3 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 2.16179241617444e-13 7.15402467027031e-12 1.02015806111697 0.588461538461538 11.3 11 3 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 4.93480494150399e-10 6.10628472326972e-09 1.01976584348486 0.588235294117647 11.3 11 3 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 2.47969962125525e-05 0.000114565342891111 1.01976584348486 0.588235294117647 11.3 11 3 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 2.47969962125525e-05 0.000114565342891111 1.01976584348486 0.588235294117647 11.3 11 3 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0068211800181456 0.0161238192123276 1.01976584348486 0.588235294117647 11.3 11 3 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.0068211800181456 0.0161238192123276 1.01976584348486 0.588235294117647 11.3 11 3 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0068211800181456 0.0161238192123276 1.01976584348486 0.588235294117647 11.3 11 3 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%REACT_216222.1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 0.0516383982518129 0.0912812928103476 1.01976584348486 0.588235294117647 11.3 11 3 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0516383982518129 0.0912812928103476 1.01976584348486 0.588235294117647 11.3 11 3 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.00185725813366494 0.0054046591497039 1.01754896121641 0.58695652173913 11.3 11 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0128719560665028 0.0287547778377292 1.0162494095418 0.586206896551724 11.3 11 3 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.00344133310852572 0.00915330282884505 1.01479137595566 0.585365853658537 11.3 11 3 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 4.5670717683831e-25 6.49894312640916e-23 1.01289101757372 0.584269662921348 11.3 11 3 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.00175305414786304 0.00511187715657605 1.01126779478915 0.583333333333333 11.3 11 3 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.0245846089844397 0.0500484958295533 1.01126779478915 0.583333333333333 11.3 11 3 P38MAPK EVENTS%REACTOME%REACT_207601.1 P38MAPK EVENTS 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%REACT_198684.2 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 ATF6-ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605532 ATF6-ALPHA ACTIVATES CHAPERONES 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%REACT_198694.2 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%REACT_198527.2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%REACT_218887.1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL 0.104714899340596 0.164469427993011 1.01126779478915 0.583333333333333 11.3 11 3 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.00641560774957292 0.015720904137326 1.01126779478915 0.583333333333333 11.3 11 3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.00641560774957292 0.015720904137326 1.01126779478915 0.583333333333333 11.3 11 3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 3.92257730181283e-09 4.04480253657946e-08 1.008819204487 0.581920903954802 11.3 11 3 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.00323972338309472 0.00864939282203336 1.00790810111875 0.581395348837209 11.3 11 3 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.0120546674442677 0.0269713707125674 1.00660757453666 0.580645161290323 11.3 11 3 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 1.42059546725872e-07 1.12305963883842e-06 1.00621650710289 0.58041958041958 11.3 11 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 3.61899442917185e-05 0.000160932158522236 1.00470112079701 0.579545454545455 11.3 11 3 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.0477715029556248 0.087064780056484 1.00366427753509 0.578947368421053 11.3 11 3 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0477715029556248 0.087064780056484 1.00366427753509 0.578947368421053 11.3 11 3 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 1.89758936225341e-05 9.15345648300542e-05 1.00366427753509 0.578947368421053 11.3 11 3 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 1.89758936225341e-05 9.15345648300542e-05 1.00366427753509 0.578947368421053 11.3 11 3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.000437715874228003 0.00147364980970131 1.00223861804996 0.578125 11.3 11 3 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.00155311967389313 0.00461396512724409 1.00015496187938 0.576923076923077 11.3 11 3 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.0228870450515144 0.0467934843510128 1.00015496187938 0.576923076923077 11.3 11 3 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.0228870450515144 0.0467934843510128 1.00015496187938 0.576923076923077 11.3 11 3 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.0228870450515144 0.0467934843510128 1.00015496187938 0.576923076923077 11.3 11 3 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.0112623885968075 0.0254386967829477 0.998134446804874 0.575757575757576 11.3 11 3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.0112623885968075 0.0254386967829477 0.998134446804874 0.575757575757576 11.3 11 3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 5.81333226647706e-05 0.000244022767409937 0.996322950531181 0.574712643678161 11.3 11 3 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 4.03163514928606e-09 4.12735022836983e-08 0.993209441310771 0.572916666666667 11.3 11 3 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 7.90736919970529e-06 4.24610806459646e-05 0.992881107611164 0.572727272727273 11.3 11 3 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.010501822345162 0.0237963267470789 0.990629676528145 0.571428571428571 11.3 11 3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0212593359109271 0.0437168135856203 0.990629676528145 0.571428571428571 11.3 11 3 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_216944.1 FGFR1 LIGAND BINDING AND ACTIVATION 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 SHC-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604825 SHC-MEDIATED SIGNALLING 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 48%5605583 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%REACT_214529.1 REGULATION OF GENE EXPRESSION IN BETA CELLS 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.0953409602335192 0.151248814283498 0.990629676528145 0.571428571428571 11.3 11 3 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 3.68438094369638e-14 1.49005969393593e-12 0.989110305858624 0.570552147239264 11.3 11 3 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 1.17839840395319e-18 9.31589404902997e-17 0.987297962369419 0.569506726457399 11.3 11 3 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000660155534041112 0.00219486290873949 0.986819562387653 0.569230769230769 11.3 11 3 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00977707633398432 0.0221894411854222 0.98393623276782 0.567567567567568 11.3 11 3 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.0197135423861598 0.0405967739732349 0.982374429223744 0.566666666666667 11.3 11 3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.0197135423861598 0.0405967739732349 0.982374429223744 0.566666666666667 11.3 11 3 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.00458641920841599 0.0117403081292185 0.97986196265284 0.565217391304348 11.3 11 3 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.0406148808901742 0.0751560149632223 0.97986196265284 0.565217391304348 11.3 11 3 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.00427154678147872 0.0110116142573265 0.975151087832393 0.5625 11.3 11 3 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.00427154678147872 0.0110116142573265 0.975151087832393 0.5625 11.3 11 3 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.00427154678147872 0.0110116142573265 0.975151087832393 0.5625 11.3 11 3 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME%REACT_196536.2 ACTIVATED POINT MUTANTS OF FGFR2 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%REACT_220758.1 PKA ACTIVATION IN GLUCAGON SIGNALLING 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 SIGNALING BY FGFR2 MUTANTS%REACTOME%REACT_196535.2 SIGNALING BY FGFR2 MUTANTS 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%REACT_212198.1 FGFR2 LIGAND BINDING AND ACTIVATION 0.0867489278311043 0.139169925934229 0.975151087832393 0.5625 11.3 11 3 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.00397462635345582 0.0104352274925602 0.970817082997583 0.56 11.3 11 3 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.0373747799138293 0.0695219762318681 0.970817082997583 0.56 11.3 11 3 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 3.67488916166377e-11 5.33608905821178e-10 0.97006606410924 0.55956678700361 11.3 11 3 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.000848769711469795 0.00274499840777618 0.965863934614942 0.557142857142857 11.3 11 3 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.000848769711469795 0.00274499840777618 0.965863934614942 0.557142857142857 11.3 11 3 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.0343659400580651 0.0640927034110442 0.963112185513475 0.555555555555556 11.3 11 3 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 48%5605625 SODIUM PROTON EXCHANGERS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 PYRIMIDINE SALVAGE REACTIONS%REACTOME DATABASE ID RELEASE 48%5604748 PYRIMIDINE SALVAGE REACTIONS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 P75NTR REGULATES AXONOGENESIS%REACTOME%REACT_222662.1 P75NTR REGULATES AXONOGENESIS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%REACT_198350.2 EGFR TRANSACTIVATION BY GASTRIN 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%REACT_199094.2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%REACT_199095.2 O2 CO2 EXCHANGE IN ERYTHROCYTES 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%REACT_199098.2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%REACT_227667.1 ELEVATION OF CYTOSOLIC CA2+ LEVELS 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 48%5604914 RAF MAP KINASE CASCADE 0.199480252601512 0.272680498993229 0.963112185513475 0.555555555555556 11.3 11 3 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 1.23213719286214e-06 8.47019915672866e-06 0.961869460112812 0.554838709677419 11.3 11 3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 2.54938412264969e-22 3.02314467210876e-20 0.957120818885086 0.552099533437014 11.3 11 3 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 2.08896427884625e-17 1.35118007672646e-15 0.956107733255195 0.551515151515152 11.3 11 3 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME%REACT_196514.2 CHONDROITIN SULFATE BIOSYNTHESIS 0.0718255564532533 0.117076479762863 0.95348106365834 0.55 11.3 11 3 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 7.35313166473568e-17 4.3597943162162e-15 0.951366914958432 0.548780487804878 11.3 11 3 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.0290136048156001 0.0577431603532853 0.950684931506849 0.548387096774194 11.3 11 3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.0290136048156001 0.0577431603532853 0.950684931506849 0.548387096774194 11.3 11 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.00218506419096842 0.00620628012724164 0.945601054867775 0.545454545454545 11.3 11 3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.0266477070756604 0.0539398110507322 0.945601054867775 0.545454545454545 11.3 11 3 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604755 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5605486 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%REACT_196478.2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5605115 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS 0.176748012875767 0.244661889418499 0.945601054867775 0.545454545454545 11.3 11 3 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0244714097906789 0.049889421392745 0.941098192701738 0.542857142857143 11.3 11 3 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604722 CYTOSOLIC TRNA AMINOACYLATION 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0595597476878605 0.103737479754988 0.939034380875638 0.541666666666667 11.3 11 3 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 5.32155669301398e-06 3.15523965589954e-05 0.938574295436698 0.54140127388535 11.3 11 3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 3.19887869288522e-30 5.86931898047976e-28 0.937082126445543 0.540540540540541 11.3 11 3 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%REACT_198975.2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%REACT_225107.1 PLATELET ADHESION TO EXPOSED COLLAGEN 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 CS DS DEGRADATION%REACTOME%REACT_198981.2 CS DS DEGRADATION 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.157410036182438 0.220250227618101 0.933477964420752 0.538461538461538 11.3 11 3 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5605561 STRIATED MUSCLE CONTRACTION 0.0494889448432242 0.0879185624368391 0.928715321745136 0.535714285714286 11.3 11 3 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.045146519309143 0.0829026599475024 0.924587698092936 0.533333333333333 11.3 11 3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604749 RNA POLYMERASE I PROMOTER OPENING 0.045146519309143 0.0829026599475024 0.924587698092936 0.533333333333333 11.3 11 3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.140746017679372 0.201173535962805 0.924587698092936 0.533333333333333 11.3 11 3 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605485 RAP1 SIGNALLING 0.140746017679372 0.201173535962805 0.924587698092936 0.533333333333333 11.3 11 3 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.0412058797380957 0.076150606321182 0.92097602739726 0.53125 11.3 11 3 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.0376274681397767 0.069900635982901 0.91778925913637 0.529411764705882 11.3 11 3 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.126248273607807 0.192346138483843 0.91778925913637 0.529411764705882 11.3 11 3 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.126248273607807 0.192346138483843 0.91778925913637 0.529411764705882 11.3 11 3 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.126248273607807 0.192346138483843 0.91778925913637 0.529411764705882 11.3 11 3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.00108964823206328 0.00343046335005763 0.913403169486973 0.526881720430108 11.3 11 3 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 48%5604916 PROLONGED ERK ACTIVATION EVENTS 0.113541880684423 0.176966151384374 0.91242207048645 0.526315789473684 11.3 11 3 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.0262793744960097 0.0533460055746388 0.908077203484133 0.523809523809524 11.3 11 3 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.0262793744960097 0.0533460055746388 0.908077203484133 0.523809523809524 11.3 11 3 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.102340092818667 0.161811057867738 0.908077203484133 0.523809523809524 11.3 11 3 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.000622320385156105 0.00207878382177732 0.90730568504447 0.523364485981308 11.3 11 3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.00188284352925186 0.00546793131045999 0.906201010914951 0.522727272727273 11.3 11 3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%REACT_216539.1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX 0.0169210741437094 0.0362033444654926 0.90013946569144 0.519230769230769 11.3 11 3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.0757199650018003 0.122862190343602 0.898904706479243 0.518518518518518 11.3 11 3 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.0686746733000161 0.112197543175572 0.896690655478063 0.517241379310345 11.3 11 3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.0623549614355885 0.106135696490353 0.894762288477035 0.516129032258065 11.3 11 3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.00335860575426855 0.00894999248749841 0.886063210672397 0.511111111111111 11.3 11 3 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.0324817334538122 0.0625639780400896 0.886063210672397 0.511111111111111 11.3 11 3 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.00673242001743253 0.0159937123285584 0.877502213467833 0.506172839506173 11.3 11 3 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.00673242001743253 0.0159937123285584 0.877502213467833 0.506172839506173 11.3 11 3 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000117948324836313 0.000454852212038139 0.876880047973315 0.505813953488372 11.3 11 3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 1.37881905058213e-05 6.93307246988825e-05 0.870521142785999 0.502145922746781 11.3 11 3 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.0517171613974447 0.0913070976036771 0.866800966962127 0.5 11.3 11 3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.0922028272908891 0.147255469399478 0.866800966962127 0.5 11.3 11 3 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.101950985160376 0.161375141138171 0.866800966962127 0.5 11.3 11 3 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.112909788299592 0.176173935033245 0.866800966962127 0.5 11.3 11 3 AMINE-DERIVED HORMONES%REACTOME%REACT_215158.1 AMINE-DERIVED HORMONES 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 ACYL CHAIN REMODELLING OF PS%REACTOME%REACT_199030.2 ACYL CHAIN REMODELLING OF PS 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.219479112131356 0.297163441068429 0.866800966962127 0.5 11.3 11 3 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605513 DSCAM INTERACTIONS 0.248781126410939 0.331475227418321 0.866800966962127 0.5 11.3 11 3 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%REACT_196539.2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 0.248781126410939 0.331475227418321 0.866800966962127 0.5 11.3 11 3 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.00163912654812683 0.00485932724580101 0.866800966962127 0.5 11.3 11 3 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.0757204082440893 0.122862190343602 0.866800966962127 0.5 11.3 11 3 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.0757204082440893 0.122862190343602 0.866800966962127 0.5 11.3 11 3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0835040431330815 0.134876564561152 0.866800966962127 0.5 11.3 11 3 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 INSULIN PROCESSING%REACTOME%REACT_207837.1 INSULIN PROCESSING 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 ACYL CHAIN REMODELLING OF PE%REACTOME%REACT_199027.2 ACYL CHAIN REMODELLING OF PE 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%REACT_215561.1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX) 0.155258204915592 0.218312673512735 0.866800966962127 0.5 11.3 11 3 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.19474310752764 0.26878704365842 0.866800966962127 0.5 11.3 11 3 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188252.2 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%REACT_224551.1 VEGF LIGAND-RECEPTOR INTERACTIONS 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 ROLE OF DCC IN REGULATING APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5605494 ROLE OF DCC IN REGULATING APOPTOSIS 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 SIGNALING BY VEGF%REACTOME%REACT_227951.1 SIGNALING BY VEGF 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%REACT_196577.2 MASTL FACILITATES MITOTIC PROGRESSION 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 KERATAN SULFATE DEGRADATION%REACTOME%REACT_198960.2 KERATAN SULFATE DEGRADATION 0.284161840701128 0.369956358021689 0.866800966962127 0.5 11.3 11 3 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.038605027508635 0.0716231475160204 0.851040949380998 0.490909090909091 11.3 11 3 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.00728933105807991 0.017201854221638 0.849464947622885 0.49 11.3 11 3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.0507613054429782 0.0900665057922169 0.849111151309839 0.489795918367347 11.3 11 3 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.0737806946449238 0.120125776292593 0.845659479963051 0.48780487804878 11.3 11 3 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0811723308860012 0.131259348694068 0.844575301142586 0.487179487179487 11.3 11 3 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0811723308860012 0.131259348694068 0.844575301142586 0.487179487179487 11.3 11 3 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.0893892461458925 0.142922356478208 0.843373913800989 0.486486486486487 11.3 11 3 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.108755906607104 0.170065555057043 0.840534270993578 0.484848484848485 11.3 11 3 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.108755906607104 0.170065555057043 0.840534270993578 0.484848484848485 11.3 11 3 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.108755906607104 0.170065555057043 0.840534270993578 0.484848484848485 11.3 11 3 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.133008876230046 0.197126603728779 0.836911278446192 0.482758620689655 11.3 11 3 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.147443195647541 0.208146495442908 0.834697227445012 0.481481481481481 11.3 11 3 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.163751078433022 0.228001746193924 0.832128928283642 0.48 11.3 11 3 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.163751078433022 0.228001746193924 0.832128928283642 0.48 11.3 11 3 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.163751078433022 0.228001746193924 0.832128928283642 0.48 11.3 11 3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.0708551993357211 0.115627234695793 0.830684260005372 0.479166666666667 11.3 11 3 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 0.00104288710173162 0.00329784076836465 0.829519204942251 0.478494623655914 11.3 11 3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.0777554276379236 0.126020470989482 0.829113968398557 0.478260869565217 11.3 11 3 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.182256568526158 0.25204188242247 0.829113968398557 0.478260869565217 11.3 11 3 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.20336557954916 0.277458504025364 0.825524730440121 0.476190476190476 11.3 11 3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.20336557954916 0.277458504025364 0.825524730440121 0.476190476190476 11.3 11 3 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.0515482335958021 0.0912812928103476 0.824171411209892 0.475409836065574 11.3 11 3 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.034698069781675 0.0646274257844549 0.821179863437805 0.473684210526316 11.3 11 3 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.22759655152208 0.304103185742648 0.821179863437805 0.473684210526316 11.3 11 3 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.067449018899894 0.110321786085689 0.819520914218739 0.472727272727273 11.3 11 3 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604915 FRS2-MEDIATED ACTIVATION 0.255627404345269 0.339643133877981 0.815812674787884 0.470588235294118 11.3 11 3 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0886305670100707 0.141868725371575 0.813731520005262 0.469387755102041 11.3 11 3 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.00221812007240154 0.00628761924905855 0.809600903152444 0.467005076142132 11.3 11 3 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604917 ARMS-MEDIATED ACTIVATION 0.288370569776841 0.374408139409165 0.809014235831319 0.466666666666667 11.3 11 3 ACYL CHAIN REMODELLING OF PG%REACTOME%REACT_199039.2 ACYL CHAIN REMODELLING OF PG 0.288370569776841 0.374408139409165 0.809014235831319 0.466666666666667 11.3 11 3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.106630220645761 0.167293058411155 0.809014235831319 0.466666666666667 11.3 11 3 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS%REACTOME%REACT_215628.1 SIGNAL REGULATORY PROTEIN (SIRP) FAMILY INTERACTIONS 0.327099203749655 0.412432143113493 0.800123969503502 0.461538461538462 11.3 11 3 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.327099203749655 0.412432143113493 0.800123969503502 0.461538461538462 11.3 11 3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.230471384040887 0.307655515469215 0.794567553048617 0.458333333333333 11.3 11 3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.171451133823488 0.238290950701047 0.792503741222516 0.457142857142857 11.3 11 3 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.11081476249045 0.173094848544359 0.788000879056479 0.454545454545455 11.3 11 3 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.189046781961569 0.261178224010983 0.788000879056479 0.454545454545455 11.3 11 3 ACYL CHAIN REMODELLING OF PC%REACTOME%REACT_199038.2 ACYL CHAIN REMODELLING OF PC 0.25676181393269 0.340832146666248 0.788000879056479 0.454545454545455 11.3 11 3 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 48%5605545 CD28 DEPENDENT VAV1 PATHWAY 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 48%5605649 PASSIVE TRANSPORT BY AQUAPORINS 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%REACT_198976.2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198583.2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.37367336388893 0.454476236593118 0.788000879056479 0.454545454545455 11.3 11 3 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.208679201128398 0.284163160962402 0.782917002417405 0.451612903225806 11.3 11 3 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.208679201128398 0.284163160962402 0.782917002417405 0.451612903225806 11.3 11 3 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.087610915659125 0.140394519124927 0.781341716698256 0.450704225352113 11.3 11 3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.286782471472844 0.373026925873726 0.780120870265915 0.45 11.3 11 3 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.122483172842765 0.189243816455217 0.77048974841078 0.444444444444444 11.3 11 3 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.145005477641703 0.2049084356347 0.77048974841078 0.444444444444444 11.3 11 3 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 48%5605607 CGMP EFFECTS 0.321272803973879 0.40673594310928 0.77048974841078 0.444444444444444 11.3 11 3 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.321272803973879 0.40673594310928 0.77048974841078 0.444444444444444 11.3 11 3 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.158128272552106 0.220820934093863 0.76678547077419 0.442307692307692 11.3 11 3 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.048803691639137 0.087064780056484 0.764422899998097 0.440944881889764 11.3 11 3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.157623949051323 0.22033288752459 0.760351725405375 0.43859649122807 11.3 11 3 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.25233452348448 0.335581333568612 0.758450846091861 0.4375 11.3 11 3 HDL-MEDIATED LIPID TRANSPORT%REACTOME%REACT_213857.1 HDL-MEDIATED LIPID TRANSPORT 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 48%5605585 CRMPS IN SEMA3A SIGNALING 0.361191929303998 0.446652550018126 0.758450846091861 0.4375 11.3 11 3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.171475708726544 0.238290950701047 0.75648084389422 0.436363636363636 11.3 11 3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%REACT_196445.2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 0.0392790037426292 0.0727786749033352 0.755127222752283 0.43558282208589 11.3 11 3 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.042116874371767 0.0777332194954922 0.753739971271415 0.434782608695652 11.3 11 3 PEPTIDE HORMONE METABOLISM%REACTOME%REACT_206913.1 PEPTIDE HORMONE METABOLISM 0.143581035732555 0.203097230464638 0.753739971271415 0.434782608695652 11.3 11 3 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.045150781067684 0.0829026599475024 0.752317820382224 0.433962264150943 11.3 11 3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.045150781067684 0.0829026599475024 0.752317820382224 0.433962264150943 11.3 11 3 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.277980507456579 0.363906404885659 0.75122750470051 0.433333333333333 11.3 11 3 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.0481753276416749 0.087064780056484 0.749087255399369 0.432098765432099 11.3 11 3 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.0217188759858509 0.0445973456390559 0.744961473614037 0.429718875502008 11.3 11 3 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.349345140415607 0.437603991911452 0.742972257396109 0.428571428571429 11.3 11 3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 48%5604920 SIGNALLING TO P38 VIA RIT AND RIN 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%REACT_198587.2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 FCGR ACTIVATION%REACTOME%REACT_196487.2 FCGR ACTIVATION 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198586.2 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%REACT_198589.2 ACTIVATION OF NICOTINIC ACETYLCHOLINE RECEPTORS 0.407814272463379 0.48766362160957 0.742972257396109 0.428571428571429 11.3 11 3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.024348930386076 0.049710943958947 0.741029846265662 0.427450980392157 11.3 11 3 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.197495380271871 0.272321633843869 0.73891229970542 0.426229508196721 11.3 11 3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.338308927706829 0.424526987766153 0.733446972044877 0.423076923076923 11.3 11 3 PLATELET CALCIUM HOMEOSTASIS%REACTOME%REACT_215282.1 PLATELET CALCIUM HOMEOSTASIS 0.389400987575188 0.467609793518559 0.72993765638916 0.421052631578947 11.3 11 3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%REACT_196519.2 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 0.389400987575188 0.467609793518559 0.72993765638916 0.421052631578947 11.3 11 3 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605082 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION 0.0969837793991823 0.153683650428771 0.726994359387591 0.419354838709677 11.3 11 3 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 48%5605622 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN 0.435087096775109 0.517233866926466 0.713836090439399 0.411764705882353 11.3 11 3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.316591881356973 0.401524284466107 0.707592626091533 0.408163265306122 11.3 11 3 ELASTIC FIBRE FORMATION%REACTOME%REACT_198996.2 ELASTIC FIBRE FORMATION 0.365985153423144 0.446652550018126 0.702811594834157 0.405405405405405 11.3 11 3 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.342064047227377 0.428860915598729 0.700817803075762 0.404255319148936 11.3 11 3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.217113677446166 0.29508382331031 0.695971579312657 0.401459854014599 11.3 11 3 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198524.2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC) 0.21249300512895 0.289079872178294 0.695882466434384 0.401408450704225 11.3 11 3 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.224601793148513 0.303186111923749 0.693440773569702 0.4 11.3 11 3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605601 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS 0.487443407587738 0.571831796370446 0.693440773569702 0.4 11.3 11 3 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%REACT_202834.1 INITIAL TRIGGERING OF COMPLEMENT 0.487443407587738 0.571831796370446 0.693440773569702 0.4 11.3 11 3 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.272898878044508 0.357582968192757 0.69023039961799 0.398148148148148 11.3 11 3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.250500809789149 0.333454305266566 0.688341944352277 0.397058823529412 11.3 11 3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 48%5605076 EUKARYOTIC TRANSLATION TERMINATION 0.272222558542415 0.357025530696642 0.683317550597881 0.394160583941606 11.3 11 3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%REACT_198575.2 TERMINATION OF O-GLYCAN BIOSYNTHESIS 0.507514374012254 0.592933459950277 0.674178529859432 0.388888888888889 11.3 11 3 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.494434102925869 0.57955496578543 0.666769974586252 0.384615384615385 11.3 11 3 G-PROTEIN ACTIVATION%REACTOME%REACT_205726.1 G-PROTEIN ACTIVATION 0.547746418191502 0.636799961671983 0.666769974586252 0.384615384615385 11.3 11 3 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.547746418191502 0.636799961671983 0.666769974586252 0.384615384615385 11.3 11 3 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.330854215098492 0.415538877392016 0.665328309776336 0.383783783783784 11.3 11 3 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.482197118818292 0.566611478182022 0.654189409028021 0.377358490566038 11.3 11 3 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.576413849433877 0.669581149179107 0.638695449340515 0.368421052631579 11.3 11 3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.581251562765643 0.674650060208409 0.625233484366125 0.360655737704918 11.3 11 3 TRP CHANNELS%REACTOME%REACT_227861.1 TRP CHANNELS 0.598531756863793 0.677239403844843 0.624096696212732 0.36 11.3 11 3 REGULATION OF COMPLEMENT CASCADE%REACTOME%REACT_198562.2 REGULATION OF COMPLEMENT CASCADE 0.598531756863793 0.677239403844843 0.624096696212732 0.36 11.3 11 3 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.781220049374005 0.848607733022297 0.62071405829288 0.358048780487805 11.3 11 3 ENDOGENOUS STEROLS%REACTOME%REACT_227038.1 ENDOGENOUS STEROLS 0.625486499151569 0.698639943714822 0.619143547830091 0.357142857142857 11.3 11 3 ACYL CHAIN REMODELLING OF PI%REACTOME%REACT_199024.2 ACYL CHAIN REMODELLING OF PI 0.625486499151569 0.698639943714822 0.619143547830091 0.357142857142857 11.3 11 3 INFLAMMASOMES%REACTOME%REACT_198656.2 INFLAMMASOMES 0.625486499151569 0.698639943714822 0.619143547830091 0.357142857142857 11.3 11 3 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.618985894526236 0.693556636150262 0.616391798728624 0.355555555555556 11.3 11 3 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.625091844575369 0.698639943714822 0.611859506090913 0.352941176470588 11.3 11 3 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.766329414493864 0.83690464836897 0.591961635974136 0.341463414634146 11.3 11 3 TRANSPORT OF ORGANIC ANIONS%REACTOME%REACT_210189.1 TRANSPORT OF ORGANIC ANIONS 0.694508044933485 0.774910560033956 0.577867311308085 0.333333333333333 11.3 11 3 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.710943739904025 0.78729411819722 0.577867311308085 0.333333333333333 11.3 11 3 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.799027439423838 0.865968047448684 0.571909916346146 0.329896907216495 11.3 11 3 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.750614532608209 0.821002674789763 0.559226430298147 0.32258064516129 11.3 11 3 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.750614532608209 0.821002674789763 0.559226430298147 0.32258064516129 11.3 11 3 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.749168074239432 0.820682193720332 0.554752618855761 0.32 11.3 11 3 AMYLOIDS%REACTOME%REACT_198563.2 AMYLOIDS 0.848424435056801 0.908433386821541 0.548608206938055 0.316455696202532 11.3 11 3 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.884758802502246 0.941669241556242 0.542845050016686 0.313131313131313 11.3 11 3 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605546 PD-1 SIGNALING 0.754196113285987 0.824286535488448 0.54175060435133 0.3125 11.3 11 3 G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605144 G ALPHA (S) SIGNALLING EVENTS 0.910343086714548 0.963852836603275 0.533415979669001 0.307692307692308 11.3 11 3 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.825375688875029 0.89316319792332 0.520080580177276 0.3 11.3 11 3 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%REACT_196572.2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE) 0.855959798256909 0.914437532221908 0.503303787268332 0.290322580645161 11.3 11 3 PROLACTIN RECEPTOR SIGNALING%REACTOME%REACT_198561.2 PROLACTIN RECEPTOR SIGNALING 0.875373925650589 0.933076476554898 0.501832138767547 0.289473684210526 11.3 11 3 COMPLEMENT CASCADE%REACTOME%REACT_208792.1 COMPLEMENT CASCADE 0.878387205338314 0.9355875697578 0.495314838264073 0.285714285714286 11.3 11 3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%REACT_199077.2 VOLTAGE GATED POTASSIUM CHANNELS 0.912239387026698 0.965142489025272 0.483795888537001 0.27906976744186 11.3 11 3 REPRODUCTION%REACTOME%REACT_199085.2 REPRODUCTION 0.871914522755395 0.930085731544923 0.472800527433888 0.272727272727273 11.3 11 3 FERTILIZATION%REACTOME%REACT_199082.2 FERTILIZATION 0.871914522755395 0.930085731544923 0.472800527433888 0.272727272727273 11.3 11 3 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%REACT_202937.1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL 0.956477509084848 1 0.457932586319614 0.264150943396226 11.3 11 3 XENOBIOTICS%REACTOME DATABASE ID RELEASE 48%5604878 XENOBIOTICS 0.943708646146778 0.995476207165949 0.454038601742067 0.261904761904762 11.3 11 3 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605563 AMINE LIGAND-BINDING RECEPTORS 0.938035273636939 0.990225663490627 0.445783354437665 0.257142857142857 11.3 11 3 INTRINSIC PATHWAY%REACTOME DATABASE ID RELEASE 48%5605102 INTRINSIC PATHWAY 0.908048215025393 0.962138950097643 0.433400483481064 0.25 11.3 11 3 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%REACT_196457.2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 0.959338214818863 1 0.404507117915659 0.233333333333333 11.3 11 3 SCAVENGING OF HEME FROM PLASMA%REACTOME%REACT_196575.2 SCAVENGING OF HEME FROM PLASMA 0.959978838850176 1 0.376869985635708 0.217391304347826 11.3 11 3 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 48%5605147 GPCR LIGAND BINDING 0.999999999973211 1 0.370847836380704 0.213917525773196 11.3 11 3 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%REACT_225768.1 GENERATION OF SECOND MESSENGER MOLECULES 0.97010189284667 1 0.361167069567553 0.208333333333333 11.3 11 3 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605522 G ALPHA (I) SIGNALLING EVENTS 0.999999867969505 1 0.359502705191666 0.207373271889401 11.3 11 3 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605492 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS) 0.999999997439788 1 0.359103257741453 0.207142857142857 11.3 11 3 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 48%5605490 CHEMOKINE RECEPTORS BIND CHEMOKINES 0.997838489495688 1 0.325050362610798 0.1875 11.3 11 3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%REACT_196447.2 IRF3-MEDIATED INDUCTION OF TYPE I IFN 0.991217836353247 1 0.309571773915045 0.178571428571429 11.3 11 3 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605491 PEPTIDE LIGAND-BINDING RECEPTORS 0.999999990540786 1 0.305350340634386 0.176136363636364 11.3 11 3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 48%5604784 SIGNALING BY GPCR 1 1 0.296939374072668 0.171284634760705 11.3 11 3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 48%5605537 REGULATION OF IGF ACTIVITY BY IGFBP 0.996671057908719 1 0.279613215149073 0.161290322580645 11.3 11 3 GPCR DOWNSTREAM SIGNALING%REACTOME%REACT_223625.1 GPCR DOWNSTREAM SIGNALING 1 1 0.257062131250974 0.148282097649186 11.3 11 3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%REACT_199000.2 ACTIVATION OF MATRIX METALLOPROTEINASES 0.999957235491866 1 0.216700241740532 0.125 11.3 11 3 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 48%5605539 OLFACTORY SIGNALING PATHWAY 1 1 0.0251651893634166 0.0145161290322581 11.3 11 3 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604680 PROPIONYL-COA CATABOLISM 0.000220775430266384 0.00270830549369883 4.383907316299 1 11.1 11 1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 48%5605551 BETA-OXIDATION OF PRISTANOYL-COA 5.09656873252146e-05 0.000771533755997663 3.83591890176163 0.875 11.1 11 1 METABOLISM OF FOLATE AND PTERINES%REACTOME%REACT_220137.1 METABOLISM OF FOLATE AND PTERINES 5.09656873252146e-05 0.000771533755997663 3.83591890176163 0.875 11.1 11 1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%REACT_218811.1 VITAMIN D (CALCIFEROL) METABOLISM 0.000241226241063347 0.00290902492400968 3.757634842542 0.857142857142857 11.1 11 1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%REACT_199096.2 REVERSIBLE HYDRATION OF CARBON DIOXIDE 2.21702746613508e-06 5.53478962159688e-05 3.65325609691583 0.833333333333333 11.1 11 1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%REACT_198964.2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 0.000812007902277744 0.00717693940957286 3.28793048722425 0.75 11.1 11 1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604711 TRYPTOPHAN CATABOLISM 0.000135810740116974 0.00180615591763041 3.18829623003564 0.727272727272727 11.1 11 1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%REACT_189118.2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM 2.32805727275561e-05 0.000394383987991814 3.131362368785 0.714285714285714 11.1 11 1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 48%5605151 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS 0.00331606766473055 0.0186512422407572 3.131362368785 0.714285714285714 11.1 11 1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%REACT_210980.1 GLUTATHIONE SYNTHESIS AND RECYCLING 0.00331606766473055 0.0186512422407572 3.131362368785 0.714285714285714 11.1 11 1 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%REACT_196556.2 ABACAVIR TRANSPORT AND METABOLISM 0.000537338249698997 0.00509754886214448 3.0687351214093 0.7 11.1 11 1 BIOTIN TRANSPORT AND METABOLISM%REACTOME%REACT_206176.1 BIOTIN TRANSPORT AND METABOLISM 0.000537338249698997 0.00509754886214448 3.0687351214093 0.7 11.1 11 1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 48%5604681 MITOCHONDRIAL FATTY ACID BETA-OXIDATION 5.81457009305e-05 0.000853003427052593 2.92260487753267 0.666666666666667 11.1 11 1 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%REACT_198609.2 ORGANIC CATION ANION ZWITTERION TRANSPORT 0.000340742149889052 0.00377211417459651 2.92260487753267 0.666666666666667 11.1 11 1 METHYLATION%REACTOME DATABASE ID RELEASE 48%5604881 METHYLATION 0.00124001139146754 0.00958987070683865 2.78975920128118 0.636363636363636 11.1 11 1 SULFUR AMINO ACID METABOLISM%REACTOME%REACT_202492.1 SULFUR AMINO ACID METABOLISM 4.53910023493074e-07 1.26649796751107e-05 2.76023793989196 0.62962962962963 11.1 11 1 ORGANIC CATION TRANSPORT%REACTOME%REACT_198610.2 ORGANIC CATION TRANSPORT 0.00748950060215189 0.0330980104250377 2.73994207268688 0.625 11.1 11 1 GAP JUNCTION DEGRADATION%REACTOME%REACT_209040.1 GAP JUNCTION DEGRADATION 0.00748950060215189 0.0330980104250377 2.73994207268688 0.625 11.1 11 1 ATF4 ACTIVATES GENES%REACTOME%REACT_90370.3 ATF4 ACTIVATES GENES 0.00432295491847395 0.0226317852855407 2.6303443897794 0.6 11.1 11 1 ONCOGENE INDUCED SENESCENCE%REACTOME%REACT_188971.2 ONCOGENE INDUCED SENESCENCE 0.000261299002293943 0.00307296264681224 2.57876900958765 0.588235294117647 11.1 11 1 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189090.2 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME%REACT_189092.2 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%REACT_189114.2 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%REACT_189095.2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME%REACT_189093.2 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME%REACT_189078.2 DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%REACT_189097.2 DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME%REACT_189088.2 DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%REACT_189110.2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%REACT_189100.2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%REACT_189075.2 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%REACT_189116.2 DEFECTS IN COBALAMIN (B12) METABOLISM 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%REACT_189096.2 DEFECTS IN BIOTIN (BTN) METABOLISM 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604686 METABOLISM OF VITAMINS AND COFACTORS 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME%REACT_189098.2 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%REACT_189091.2 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%REACT_189076.2 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 48%5604685 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME%REACT_189086.2 DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%REACT_189089.2 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1 7.46265996492075e-14 4.24774605203289e-12 2.55727926784108 0.583333333333333 11.1 11 1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604747 PYRIMIDINE CATABOLISM 0.00249898832967742 0.0150044742326201 2.55727926784108 0.583333333333333 11.1 11 1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605478 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS 0.000154702453570773 0.00198325758046135 2.53805160417311 0.578947368421053 11.1 11 1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605107 PORPHYRIN METABOLISM 0.000841364248766803 0.00725612924845552 2.46594786541819 0.5625 11.1 11 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%REACT_198536.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%REACT_199107.2 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 PHENYLALANINE AND TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604709 PHENYLALANINE AND TYROSINE CATABOLISM 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 48%5605639 PLATELET SENSITIZATION BY LDL 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%REACT_198690.2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%REACT_203051.1 TRANSPORT OF NUCLEOTIDE SUGARS 0.0142868952083305 0.0537837351361227 2.43550406461056 0.555555555555556 11.1 11 1 PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5604864 PEROXISOMAL LIPID METABOLISM 0.000167325125587376 0.00211049465575694 2.39122217252673 0.545454545454545 11.1 11 1 HEME BIOSYNTHESIS%REACTOME%REACT_203298.1 HEME BIOSYNTHESIS 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198616.2 CALNEXIN CALRETICULIN CYCLE 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 GAP JUNCTION TRAFFICKING%REACTOME%REACT_217189.1 GAP JUNCTION TRAFFICKING 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%REACT_199061.2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING 0.00802248715088164 0.0345554642485167 2.39122217252673 0.545454545454545 11.1 11 1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%REACT_209641.1 NRAGE SIGNALS DEATH THROUGH JNK 5.83212299965372e-08 1.93002582058308e-06 2.38255832407554 0.543478260869565 11.1 11 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 48%5605596 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP) 0.00454961495620966 0.0226317852855407 2.36056547800715 0.538461538461538 11.1 11 1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%REACT_198618.2 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 0.00454961495620966 0.0226317852855407 2.36056547800715 0.538461538461538 11.1 11 1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%REACT_224389.1 GAP JUNCTION TRAFFICKING AND REGULATION 0.00454961495620966 0.0226317852855407 2.36056547800715 0.538461538461538 11.1 11 1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%REACT_226192.1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 0.00259946522799586 0.0154771507089461 2.33808390202613 0.533333333333333 11.1 11 1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 48%5604676 BRANCHED-CHAIN AMINO ACID CATABOLISM 0.00149393765104877 0.0110148874478881 2.32089210862888 0.529411764705882 11.1 11 1 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604754 RNA POLYMERASE I PROMOTER ESCAPE 0.000500025738529934 0.00484038521039522 2.29633240377567 0.523809523809524 11.1 11 1 DARPP-32 EVENTS%REACTOME%REACT_203795.1 DARPP-32 EVENTS 0.000169561636684571 0.00211654569300127 2.27963180447548 0.52 11.1 11 1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%REACT_203903.1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 0.000832726351472492 0.00722542437893509 2.1919536581495 0.5 11.1 11 1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604831 RNA POLYMERASE I TRANSCRIPTION TERMINATION 0.000832726351472492 0.00722542437893509 2.1919536581495 0.5 11.1 11 1 SPRY REGULATION OF FGF SIGNALING%REACTOME%REACT_198526.2 SPRY REGULATION OF FGF SIGNALING 0.00435756620722492 0.0226317852855407 2.1919536581495 0.5 11.1 11 1 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION)%REACTOME DATABASE ID RELEASE 48%5604665 AMINO ACID SYNTHESIS AND INTERCONVERSION (TRANSAMINATION) 0.00435756620722492 0.0226317852855407 2.1919536581495 0.5 11.1 11 1 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%REACT_196541.2 ALPHA-LINOLENIC ACID (ALA) METABOLISM 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 48%5604761 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%REACT_196529.2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%REACT_214670.1 P75NTR RECRUITS SIGNALLING COMPLEXES 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 ERKS ARE INACTIVATED%REACTOME%REACT_210064.1 ERKS ARE INACTIVATED 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5605534 PERK REGULATES GENE EXPRESSION 0.0135459859720859 0.0522383144668785 2.1919536581495 0.5 11.1 11 1 COHESIN LOADING ONTO CHROMATIN%REACTOME%REACT_196634.2 COHESIN LOADING ONTO CHROMATIN 0.0242508354981871 0.0810068988589678 2.1919536581495 0.5 11.1 11 1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605619 TIGHT JUNCTION INTERACTIONS 0.0242508354981871 0.0810068988589678 2.1919536581495 0.5 11.1 11 1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605587 ACETYLCHOLINE REGULATES INSULIN SECRETION 0.0242508354981871 0.0810068988589678 2.1919536581495 0.5 11.1 11 1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%REACT_204413.1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE 3.44651817512022e-08 1.19619399102343e-06 2.15716074294078 0.492063492063492 11.1 11 1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_205251.1 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 5.32495974217834e-05 0.000794777746514719 2.1293264107738 0.485714285714286 11.1 11 1 PHASE II CONJUGATION%REACTOME DATABASE ID RELEASE 48%5604651 PHASE II CONJUGATION 2.30560611531286e-09 9.11354861691724e-08 2.10871491163749 0.481012658227848 11.1 11 1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188574.2 SHC1 EVENTS IN ERBB2 SIGNALING 0.00132951032965603 0.0101170759310189 2.09665132518648 0.478260869565217 11.1 11 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198351.2 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00132951032965603 0.0101170759310189 2.09665132518648 0.478260869565217 11.1 11 1 ERK MAPK TARGETS%REACTOME%REACT_215063.1 ERK MAPK TARGETS 0.00229299170269962 0.0145666392542034 2.08757491252333 0.476190476190476 11.1 11 1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604753 RNA POLYMERASE I TRANSCRIPTION INITIATION 2.90569668635878e-05 0.000475265101688338 2.08235597524203 0.475 11.1 11 1 NEPHRIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605498 NEPHRIN INTERACTIONS 0.0039695313055596 0.0212355001797418 2.07658767614163 0.473684210526316 11.1 11 1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%REACT_203510.1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS 0.000240923425981981 0.00290902492400968 2.05495655451516 0.46875 11.1 11 1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%REACT_204733.1 G ALPHA (12 13) SIGNALLING EVENTS 1.78150511350958e-06 4.5269317437931e-05 2.03538553971025 0.464285714285714 11.1 11 1 EGFR DOWNREGULATION%REACTOME%REACT_203917.1 EGFR DOWNREGULATION 0.00119478719516153 0.00934166032260912 2.02334183829185 0.461538461538462 11.1 11 1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 48%5604865 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS 0.0212571611285512 0.0734197579755542 2.02334183829185 0.461538461538462 11.1 11 1 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX%REACTOME%REACT_198539.2 TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX 0.0212571611285512 0.0734197579755542 2.02334183829185 0.461538461538462 11.1 11 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_115781.3 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0212571611285512 0.0734197579755542 2.02334183829185 0.461538461538462 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%REACT_221403.1 RNA POLYMERASE III TRANSCRIPTION TERMINATION 0.00204535977293858 0.0132901687529297 2.00929085330371 0.458333333333333 11.1 11 1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%REACT_196516.2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION 0.00204535977293858 0.0132901687529297 2.00929085330371 0.458333333333333 11.1 11 1 PYRIMIDINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604745 PYRIMIDINE METABOLISM 0.00204535977293858 0.0132901687529297 2.00929085330371 0.458333333333333 11.1 11 1 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%REACT_224594.1 ORGANELLE BIOGENESIS AND MAINTENANCE 4.01318056593654e-05 0.000634528438369745 1.99268514377227 0.454545454545455 11.1 11 1 MITOCHONDRIAL BIOGENESIS%REACTOME%REACT_211261.1 MITOCHONDRIAL BIOGENESIS 4.01318056593654e-05 0.000634528438369745 1.99268514377227 0.454545454545455 11.1 11 1 GLUTATHIONE CONJUGATION%REACTOME%REACT_215316.1 GLUTATHIONE CONJUGATION 0.000366185587512018 0.00400832377715079 1.99268514377227 0.454545454545455 11.1 11 1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS%REACTOME%REACT_206357.1 FACILITATIVE NA+-INDEPENDENT GLUCOSE TRANSPORTERS 0.0377744591209418 0.108373095421573 1.99268514377227 0.454545454545455 11.1 11 1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%REACT_205717.1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 0.0377744591209418 0.108373095421573 1.99268514377227 0.454545454545455 11.1 11 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%REACT_196643.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS 0.0377744591209418 0.108373095421573 1.99268514377227 0.454545454545455 11.1 11 1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604666 AMINO ACID AND DERIVATIVE METABOLISM 1.74768396507917e-17 8.28984760769221e-15 1.98645800269798 0.453125 11.1 11 1 RORA ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_118837.3 RORA ACTIVATES CIRCADIAN GENE EXPRESSION 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604763 BASE EXCISION REPAIR 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188528.2 GRB2 EVENTS IN ERBB2 SIGNALING 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 48%5604762 RESOLUTION OF ABASIC SITES (AP SITES) 0.00603980369393971 0.0283651506814396 1.97275829233455 0.45 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604908 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 0.00105344457655082 0.0086152392668495 1.96519983144438 0.448275862068966 11.1 11 1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%REACT_210847.1 P75 NTR RECEPTOR-MEDIATED SIGNALLING 2.8788096407521e-08 1.02413652969756e-06 1.95986444728661 0.447058823529412 11.1 11 1 RHO GTPASE CYCLE%REACTOME%REACT_210090.1 RHO GTPASE CYCLE 4.19323994151229e-11 1.86468138649125e-09 1.9564545047946 0.446280991735537 11.1 11 1 SIGNALING BY RHO GTPASES%REACTOME%REACT_206918.1 SIGNALING BY RHO GTPASES 4.19323994151229e-11 1.86468138649125e-09 1.9564545047946 0.446280991735537 11.1 11 1 PPARA ACTIVATES GENE EXPRESSION%REACTOME%REACT_198602.2 PPARA ACTIVATES GENE EXPRESSION 4.19323994151229e-11 1.86468138649125e-09 1.9564545047946 0.446280991735537 11.1 11 1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%REACT_198518.2 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT) 0.00178982064227234 0.0121281655902549 1.94840325168844 0.444444444444444 11.1 11 1 SYNTHESIS OF PC%REACTOME%REACT_207335.1 SYNTHESIS OF PC 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_188580.2 SHC1 EVENTS IN ERBB4 SIGNALING 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 TIE2 SIGNALING%REACTOME%REACT_211860.1 TIE2 SIGNALING 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%REACT_198620.2 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 0.0104271528784711 0.0426374670863918 1.94840325168844 0.444444444444444 11.1 11 1 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA)%REACTOME DATABASE ID RELEASE 48%5605592 REGULATION OF LIPID METABOLISM BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPARALPHA) 3.72947423571394e-11 1.83001442669687e-09 1.94447501932617 0.443548387096774 11.1 11 1 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 48%5604682 FATTY ACID, TRIACYLGLYCEROL, AND KETONE BODY METABOLISM 1.70341590323367e-15 6.05990207575379e-13 1.92987224250119 0.440217391304348 11.1 11 1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 48%5605505 SEMA4D IN SEMAPHORIN SIGNALING 0.00304483401460895 0.0172621466246555 1.92891921917156 0.44 11.1 11 1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605612 CELL-CELL JUNCTION ORGANIZATION 0.000167593742867557 0.00211049465575694 1.92464223642395 0.439024390243902 11.1 11 1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5605475 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 0.000916187491287553 0.00776032619108445 1.91795945088081 0.4375 11.1 11 1 REGULATION OF KIT SIGNALING%REACTOME%REACT_227425.1 REGULATION OF KIT SIGNALING 0.0180707910891684 0.0651005967592065 1.91795945088081 0.4375 11.1 11 1 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 48%5604675 METABOLISM OF POLYAMINES 0.0180707910891684 0.0651005967592065 1.91795945088081 0.4375 11.1 11 1 REV-ERBA REPRESSES GENE EXPRESSION%REACTOME%REACT_198352.2 REV-ERBA REPRESSES GENE EXPRESSION 0.00518708654595266 0.0249365680908467 1.90604665926043 0.434782608695652 11.1 11 1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%REACT_219232.1 EFFECTS OF PIP2 HYDROLYSIS 0.00518708654595266 0.0249365680908467 1.90604665926043 0.434782608695652 11.1 11 1 AMINE COMPOUND SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605479 AMINE COMPOUND SLC TRANSPORTERS 0.00154537244341969 0.0112535139993813 1.89969317039623 0.433333333333333 11.1 11 1 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%REACT_188202.2 FCERI MEDIATED CA+2 MOBILIZATION 0.00154537244341969 0.0112535139993813 1.89969317039623 0.433333333333333 11.1 11 1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%REACT_217615.1 TRANSPORT OF GLUCOSE AND OTHER SUGARS, BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS 2.86885179156967e-08 1.02413652969756e-06 1.89200210492904 0.431578947368421 11.1 11 1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 48%5605517 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 7.55219360919888e-05 0.00108553247534243 1.878817421271 0.428571428571429 11.1 11 1 G1 PHASE%REACTOME DATABASE ID RELEASE 48%5604624 G1 PHASE 0.000788770210571345 0.0070151250602689 1.878817421271 0.428571428571429 11.1 11 1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 48%5604623 CYCLIN D ASSOCIATED EVENTS IN G1 0.000788770210571345 0.0070151250602689 1.878817421271 0.428571428571429 11.1 11 1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5605560 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 0.00884991268736979 0.0372586560772995 1.878817421271 0.428571428571429 11.1 11 1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%REACT_196517.2 PRE-NOTCH PROCESSING IN GOLGI 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 48%5605495 DCC MEDIATED ATTRACTIVE SIGNALING 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 CELL DIVISION%REACTOME DATABASE ID RELEASE 48%5605077 CELL DIVISION 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605599 TRAFFICKING OF AMPA RECEPTORS 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 48%5605582 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 GLYCOGEN SYNTHESIS%REACTOME%REACT_188939.2 GLYCOGEN SYNTHESIS 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605598 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS 0.0314617170638388 0.0950531281992411 1.878817421271 0.428571428571429 11.1 11 1 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 48%5605593 CIRCADIAN CLOCK 0.000125441283652988 0.00170002806322097 1.86549247502085 0.425531914893617 11.1 11 1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%REACT_212101.1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER 0.000404476571142497 0.00436038000557404 1.86316060942708 0.425 11.1 11 1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%REACT_215733.1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING 0.00440153501553708 0.0226317852855407 1.85473001843419 0.423076923076923 11.1 11 1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME DATABASE ID RELEASE 48%5604887 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE 0.00440153501553708 0.0226317852855407 1.85473001843419 0.423076923076923 11.1 11 1 CIRCADIAN CLOCK%REACTOME%REACT_24972.5 CIRCADIAN CLOCK 0.000208218889613543 0.00257648243408758 1.85098308910402 0.422222222222222 11.1 11 1 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 48%5604663 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE 0.000673862317903038 0.00622666284659755 1.84585571212589 0.421052631578947 11.1 11 1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%REACT_205207.1 RNA POLYMERASE III CHAIN ELONGATION 0.0151236049314976 0.0564852751116039 1.84585571212589 0.421052631578947 11.1 11 1 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605469 ABC-FAMILY PROTEINS MEDIATED TRANSPORT 0.00221314848503877 0.0141860824063521 1.83841274554474 0.419354838709677 11.1 11 1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605611 ADHERENS JUNCTIONS INTERACTIONS 0.00221314848503877 0.0141860824063521 1.83841274554474 0.419354838709677 11.1 11 1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604858 TRIGLYCERIDE BIOSYNTHESIS 0.00112187376050377 0.00901935797286361 1.82662804845792 0.416666666666667 11.1 11 1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%REACT_198969.2 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP) 0.00112187376050377 0.00901935797286361 1.82662804845792 0.416666666666667 11.1 11 1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%REACT_222431.1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION) 0.00743117709810559 0.0330455156581383 1.82662804845792 0.416666666666667 11.1 11 1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 48%5605500 RECYCLING PATHWAY OF L1 0.00743117709810559 0.0330455156581383 1.82662804845792 0.416666666666667 11.1 11 1 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 48%5605616 FANCONI ANEMIA PATHWAY 0.00743117709810559 0.0330455156581383 1.82662804845792 0.416666666666667 11.1 11 1 SYNTHESIS OF PE%REACTOME%REACT_199009.2 SYNTHESIS OF PE 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%REACT_222715.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%REACT_226284.1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%REACT_202778.1 RETROGRADE NEUROTROPHIN SIGNALLING 0.0550805113701246 0.146754204699144 1.82662804845792 0.416666666666667 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604875 RNA POLYMERASE III TRANSCRIPTION 0.000572268574503908 0.00535748803630961 1.81771766773373 0.414634146341463 11.1 11 1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 48%5604876 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION 0.000572268574503908 0.00535748803630961 1.81771766773373 0.414634146341463 11.1 11 1 DUAL INCISION REACTION IN TC-NER%REACTOME%REACT_224562.1 DUAL INCISION REACTION IN TC-NER 0.00370472380178859 0.0199690226134286 1.81403061364097 0.413793103448276 11.1 11 1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX%REACTOME%REACT_223654.1 FORMATION OF TRANSCRIPTION-COUPLED NER (TC-NER) REPAIR COMPLEX 0.00370472380178859 0.0199690226134286 1.81403061364097 0.413793103448276 11.1 11 1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%REACT_188277.2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION) 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 48%5604718 SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 48%5604857 FATTY ACYL-COA BIOSYNTHESIS 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 48%5605575 SIGNAL AMPLIFICATION 0.0258882351826858 0.083915623382601 1.80513830671135 0.411764705882353 11.1 11 1 IRON UPTAKE AND TRANSPORT%REACTOME%REACT_205755.1 IRON UPTAKE AND TRANSPORT 0.00094724165390127 0.007924180012876 1.79852607848164 0.41025641025641 11.1 11 1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604804 SMOOTH MUSCLE CONTRACTION 0.0125468587433566 0.050578413574494 1.79341662939505 0.409090909090909 11.1 11 1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 48%5605504 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE 0.0125468587433566 0.050578413574494 1.79341662939505 0.409090909090909 11.1 11 1 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%REACT_198968.2 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF) 0.000248188198757865 0.00296783030951631 1.78934992502 0.408163265306122 11.1 11 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS%REACTOME%REACT_198246.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 0.00619708864715657 0.0290080827134993 1.78603631404774 0.407407407407407 11.1 11 1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%REACT_209370.1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%REACT_225428.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 TGFBR1 KD MUTANTS IN CANCER%REACTOME%REACT_224802.1 TGFBR1 KD MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%REACT_204241.1 LOSS OF FUNCTION OF TGFBR2 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%REACT_226256.1 LOSS OF FUNCTION OF SMAD2 3 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%REACT_224787.1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%REACT_223317.1 LOSS OF FUNCTION OF TGFBR1 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%REACT_213336.1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME%REACT_217958.1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME%REACT_215068.1 LOSS OF FUNCTION OF SMAD4 IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_216792.1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%REACT_224217.1 TGFBR1 LBD MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%REACT_202264.1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER 1.77754371709679e-05 0.000304752374629967 1.77897688197641 0.405797101449275 11.1 11 1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%REACT_196464.2 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 0.00156584383125614 0.0112535139993813 1.77725972282392 0.405405405405405 11.1 11 1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS%REACTOME%REACT_214376.1 ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 0.00156584383125614 0.0112535139993813 1.77725972282392 0.405405405405405 11.1 11 1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%REACT_206529.1 GENERIC TRANSCRIPTION PATHWAY 2.09414826746359e-09 8.51420852743056e-08 1.76617848714204 0.402877697841727 11.1 11 1 ENOS ACTIVATION AND REGULATION%REACTOME%REACT_204801.1 ENOS ACTIVATION AND REGULATION 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 METABOLISM OF NITRIC OXIDE%REACTOME%REACT_208364.1 METABOLISM OF NITRIC OXIDE 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 SIGNALING BY HIPPO%REACTOME%REACT_196537.2 SIGNALING BY HIPPO 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%REACT_210462.1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B 0.0211794724232028 0.0734197579755542 1.7535629265196 0.4 11.1 11 1 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605476 AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 0.000341955536558643 0.00377211417459651 1.7535629265196 0.4 11.1 11 1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%REACT_206830.1 E2F MEDIATED REGULATION OF DNA REPLICATION 0.00514429137403453 0.0248990701539154 1.7535629265196 0.4 11.1 11 1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%REACT_199106.2 CELLULAR RESPONSE TO HYPOXIA 0.0103554058204366 0.0426374670863918 1.7535629265196 0.4 11.1 11 1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605658 METAL ION SLC TRANSPORTERS 0.0103554058204366 0.0426374670863918 1.7535629265196 0.4 11.1 11 1 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN%REACTOME%REACT_199109.2 REGULATION OF HYPOXIA-INDUCIBLE FACTOR (HIF) BY OXYGEN 0.0103554058204366 0.0426374670863918 1.7535629265196 0.4 11.1 11 1 P75NTR SIGNALS VIA NF-KB%REACTOME%REACT_224536.1 P75NTR SIGNALS VIA NF-KB 0.0443886916375192 0.123610779256732 1.7535629265196 0.4 11.1 11 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%REACT_203193.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL 0.0443886916375192 0.123610779256732 1.7535629265196 0.4 11.1 11 1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604628 G1 S DNA DAMAGE CHECKPOINTS 7.62894069199782e-05 0.00108559826047129 1.73964576043611 0.396825396825397 11.1 11 1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 48%5604641 GLUCONEOGENESIS 0.00214757090518209 0.013890879082155 1.73048973011803 0.394736842105263 11.1 11 1 DNA REPAIR%REACTOME DATABASE ID RELEASE 48%5604757 DNA REPAIR 2.96411746896129e-07 8.60803909863656e-06 1.72943132661337 0.394495412844037 11.1 11 1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%REACT_218233.1 POST NMDA RECEPTOR ACTIVATION EVENTS 0.00425695186737735 0.0225835899404698 1.7269937912693 0.393939393939394 11.1 11 1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604626 P53-DEPENDENT G1 DNA DAMAGE RESPONSE 0.000123543651195972 0.00169040976588334 1.72481599329797 0.39344262295082 11.1 11 1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604627 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.000123543651195972 0.00169040976588334 1.72481599329797 0.39344262295082 11.1 11 1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 48%5604886 MRNA CAPPING 0.00851967129097761 0.0362128476240024 1.72224930283175 0.392857142857143 11.1 11 1 SIGNALING BY BMP%REACTOME%REACT_220505.1 SIGNALING BY BMP 0.017278140870259 0.0625618179602509 1.71544199333439 0.391304347826087 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604874 RNA POLYMERASE III TRANSCRIPTION INITIATION 0.0035149480022179 0.0195381679967034 1.70485284522739 0.388888888888889 11.1 11 1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%REACT_224790.1 CELLULAR RESPONSE TO HEAT STRESS 0.0035149480022179 0.0195381679967034 1.70485284522739 0.388888888888889 11.1 11 1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%REACT_227394.1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 48%5604679 CITRIC ACID CYCLE (TCA CYCLE) 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE%REACTOME%REACT_219337.1 REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604662 PYRUVATE METABOLISM 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR%REACTOME%REACT_199123.2 SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 0.0357271057399134 0.105040643528712 1.70485284522739 0.388888888888889 11.1 11 1 ELONGATION ARREST AND RECOVERY%REACTOME%REACT_217426.1 ELONGATION ARREST AND RECOVERY 0.0140765750734989 0.0537837351361227 1.68611819857654 0.384615384615385 11.1 11 1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%REACT_220566.1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY 0.0140765750734989 0.0537837351361227 1.68611819857654 0.384615384615385 11.1 11 1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%REACT_221775.1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%REACT_197984.2 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 NGF PROCESSING%REACTOME%REACT_206713.1 NGF PROCESSING 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 COMMON PATHWAY%REACTOME DATABASE ID RELEASE 48%5605058 COMMON PATHWAY 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 48%5604811 SIGNAL ATTENUATION 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 SIGNALING BY ACTIVIN%REACTOME%REACT_216258.1 SIGNALING BY ACTIVIN 0.0762201052711081 0.190282824211907 1.68611819857654 0.384615384615385 11.1 11 1 RETINOID METABOLISM AND TRANSPORT%REACTOME%REACT_198569.2 RETINOID METABOLISM AND TRANSPORT 0.0028977766872326 0.0171814009413833 1.68611819857654 0.384615384615385 11.1 11 1 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604642 GLUCOSE METABOLISM 4.97510388873689e-05 0.000769518786268761 1.67280673911409 0.381578947368421 11.1 11 1 CHOLESTEROL BIOSYNTHESIS%REACTOME%REACT_208531.1 CHOLESTEROL BIOSYNTHESIS 0.0287668937991001 0.0895739384597801 1.67005993001867 0.380952380952381 11.1 11 1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5605103 CYTOSOLIC SULFONATION OF SMALL MOLECULES 0.0287668937991001 0.0895739384597801 1.67005993001867 0.380952380952381 11.1 11 1 DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 48%5604847 DOUBLE-STRAND BREAK REPAIR 0.0287668937991001 0.0895739384597801 1.67005993001867 0.380952380952381 11.1 11 1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604622 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 0.00015222182344899 0.00196919686152648 1.65190710469238 0.376811594202899 11.1 11 1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%REACT_213035.1 REGULATION OF FZD BY UBIQUITINATION 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%REACT_226151.1 CD28 DEPENDENT PI3K AKT SIGNALING 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%REACT_215601.1 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 PHOSPHORYLATION OF THE APC C%REACTOME%REACT_205250.1 PHOSPHORYLATION OF THE APC C 0.0601794319665298 0.158290816429523 1.64396524361213 0.375 11.1 11 1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 48%5604625 STABILIZATION OF P53 0.000684822020886737 0.00628710797239888 1.64396524361212 0.375 11.1 11 1 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 48%5604610 G1 S TRANSITION 3.10292090860292e-06 6.89915070772181e-05 1.63400181789326 0.372727272727273 11.1 11 1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605621 GOLGI ASSOCIATED VESICLE BIOGENESIS 0.00132752854776528 0.0101170759310189 1.63322037273884 0.372549019607843 11.1 11 1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605538 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION 0.00759996615866107 0.033378863715354 1.6283084317682 0.371428571428571 11.1 11 1 HS-GAG BIOSYNTHESIS%REACTOME%REACT_198654.2 HS-GAG BIOSYNTHESIS 0.0187115670889944 0.066900904441304 1.62366937640704 0.37037037037037 11.1 11 1 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 48%5605155 MTOR SIGNALLING 0.0187115670889944 0.066900904441304 1.62366937640704 0.37037037037037 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604907 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 0.0187115670889944 0.066900904441304 1.62366937640704 0.37037037037037 11.1 11 1 INTEGRATION OF ENERGY METABOLISM%REACTOME%REACT_217323.1 INTEGRATION OF ENERGY METABOLISM 1.11610606933874e-05 0.000230176657488264 1.62204570703063 0.37 11.1 11 1 TRANSCRIPTION-COUPLED NER (TC-NER)%REACTOME%REACT_213655.1 TRANSCRIPTION-COUPLED NER (TC-NER) 0.00258252164913166 0.0154408752382956 1.62013966037137 0.369565217391304 11.1 11 1 MEMBRANE TRAFFICKING%REACTOME%REACT_209837.1 MEMBRANE TRAFFICKING 3.79825944526934e-08 1.28688647395673e-06 1.61656582288526 0.36875 11.1 11 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%REACT_207530.1 SYNTHESIS OF BILE ACIDS AND BILE SALTS 0.0477458145448224 0.131162729917533 1.61512374811016 0.368421052631579 11.1 11 1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%REACT_199411.2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 0.0477458145448224 0.131162729917533 1.61512374811016 0.368421052631579 11.1 11 1 SIGNALING BY NGF%REACTOME DATABASE ID RELEASE 48%5604788 SIGNALING BY NGF 1.09700306068602e-12 5.85350525514221e-11 1.61173063099228 0.367647058823529 11.1 11 1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%REACT_210065.1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 0.0151198405745657 0.0564852751116039 1.60743268264297 0.366666666666667 11.1 11 1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 48%5605536 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 0.000259930981938005 0.00307296264681224 1.605374510194 0.366197183098592 11.1 11 1 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME%REACT_196589.2 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS 0.0050454209581256 0.0245899479208639 1.60386853035329 0.365853658536585 11.1 11 1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%REACT_196591.2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS 0.0050454209581256 0.0245899479208639 1.60386853035329 0.365853658536585 11.1 11 1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 48%5604793 SIGNALING BY FGFR 4.74787704327479e-07 1.2992748139577e-05 1.59699480808035 0.364285714285714 11.1 11 1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%REACT_212633.1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 0.00141861863708098 0.0105140329196158 1.59414811501782 0.363636363636364 11.1 11 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 48%5604856 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D 0.00141861863708098 0.0105140329196158 1.59414811501782 0.363636363636364 11.1 11 1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1%REACTOME DATABASE ID RELEASE 48%5604855 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 0.00141861863708098 0.0105140329196158 1.59414811501782 0.363636363636364 11.1 11 1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 48%5605644 DEADENYLATION OF MRNA 0.0380354852595251 0.108902405481498 1.59414811501782 0.363636363636364 11.1 11 1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 48%5604796 SIGNALING BY EGFR 1.18880159326029e-07 3.75925481602087e-06 1.59160966260537 0.363057324840764 11.1 11 1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%REACT_223647.1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY 0.000408491792219425 0.00437055504006197 1.58837221605036 0.36231884057971 11.1 11 1 CLATHRIN DERIVED VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605473 CLATHRIN DERIVED VESICLE BUDDING 0.00116215690460987 0.00923882276681477 1.58727678693584 0.362068965517241 11.1 11 1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 48%5605474 TRANS-GOLGI NETWORK VESICLE BUDDING 0.00116215690460987 0.00923882276681477 1.58727678693584 0.362068965517241 11.1 11 1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%REACT_220647.1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21 0.000952238076037805 0.007924180012876 1.5810813271898 0.360655737704918 11.1 11 1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%REACT_198532.2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING 0.0304037078721779 0.0938729796217453 1.57820663386764 0.36 11.1 11 1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605503 SEMAPHORIN INTERACTIONS 0.000780393268103792 0.0070151250602689 1.57546669179495 0.359375 11.1 11 1 NEGATIVE REGULATION OF FGFR SIGNALING%REACTOME%REACT_198525.2 NEGATIVE REGULATION OF FGFR SIGNALING 0.00803531284612342 0.0345554642485167 1.57371031867144 0.358974358974359 11.1 11 1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%REACT_213364.1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 6.66380721810463e-05 0.000967612007281928 1.57248849388986 0.358695652173913 11.1 11 1 SIGNALING BY EGFR IN CANCER%REACTOME%REACT_188180.2 SIGNALING BY EGFR IN CANCER 1.9499578842334e-07 5.90380865800877e-06 1.571589415277 0.358490566037736 11.1 11 1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS%REACTOME%REACT_213947.1 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 0.00652269325240392 0.0297493349300345 1.5656811843925 0.357142857142857 11.1 11 1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 48%5604873 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 0.0243737314212259 0.0812267442913453 1.5656811843925 0.357142857142857 11.1 11 1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%REACT_222404.1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 INHIBITION OF ADENYLATE CYCLASE PATHWAY%REACTOME%REACT_217338.1 INHIBITION OF ADENYLATE CYCLASE PATHWAY 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%REACT_222824.1 ADENYLATE CYCLASE INHIBITORY PATHWAY 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 REGULATION OF AMPK ACTIVITY VIA LKB1%REACTOME%REACT_220701.1 REGULATION OF AMPK ACTIVITY VIA LKB1 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 48%5604919 SHC1 EVENTS IN EGFR SIGNALING 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 ACTIVATION OF RAC%REACTOME DATABASE ID RELEASE 48%5605637 ACTIVATION OF RAC 0.101085876497369 0.227963870452861 1.5656811843925 0.357142857142857 11.1 11 1 SIGNALING BY FGFR IN DISEASE%REACTOME%REACT_188177.2 SIGNALING BY FGFR IN DISEASE 5.60897421240987e-07 1.50595666118099e-05 1.55744075710622 0.355263157894737 11.1 11 1 METABOLISM OF STEROID HORMONES AND VITAMIN D%REACTOME%REACT_220061.1 METABOLISM OF STEROID HORMONES AND VITAMIN D 0.0195882061576276 0.0695112652426534 1.55558001546094 0.354838709677419 11.1 11 1 STEROID HORMONES%REACTOME%REACT_210732.1 STEROID HORMONES 0.0195882061576276 0.0695112652426534 1.55558001546094 0.354838709677419 11.1 11 1 MAP KINASE ACTIVATION IN TLR CASCADE%REACTOME DATABASE ID RELEASE 48%5604940 MAP KINASE ACTIVATION IN TLR CASCADE 0.00431004460055522 0.0226317852855407 1.55263384118923 0.354166666666667 11.1 11 1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604783 OPIOID SIGNALLING 0.000997888466515856 0.00825502182151192 1.55122874269042 0.353846153846154 11.1 11 1 MITOTIC G1-G1 S PHASES%REACTOME DATABASE ID RELEASE 48%5604611 MITOTIC G1-G1 S PHASES 3.47339904062684e-06 7.60407205355691e-05 1.54920032981995 0.353383458646617 11.1 11 1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 48%5604661 GLYCOLYSIS 0.0157760711217401 0.0583099979382756 1.54726140575259 0.352941176470588 11.1 11 1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_188190.2 PLCG1 EVENTS IN ERBB2 SIGNALING 0.0157760711217401 0.0583099979382756 1.54726140575259 0.352941176470588 11.1 11 1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%REACT_204167.1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK 0.0788837211213537 0.192872053532107 1.54726140575259 0.352941176470588 11.1 11 1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%REACT_222185.1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE 0.0788837211213537 0.192872053532107 1.54726140575259 0.352941176470588 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%REACT_226490.1 RNA POLYMERASE II TRANSCRIPTION ELONGATION 0.0127296350045137 0.0510261143983745 1.54029175978073 0.351351351351351 11.1 11 1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%REACT_226759.1 FORMATION OF RNA POL II ELONGATION COMPLEX 0.0127296350045137 0.0510261143983745 1.54029175978073 0.351351351351351 11.1 11 1 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 48%5605477 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 0.000107866687752998 0.00150484604580898 1.5390312918922 0.351063829787234 11.1 11 1 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 48%5604790 SIGNALING BY PDGF 6.10754594420984e-07 1.60945145900196e-05 1.53436756070465 0.35 11.1 11 1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME%REACT_196494.2 PRE-NOTCH EXPRESSION AND PROCESSING 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%REACT_198566.2 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 HS-GAG DEGRADATION%REACTOME%REACT_198967.2 HS-GAG DEGRADATION 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 CTLA4 INHIBITORY SIGNALING%REACTOME DATABASE ID RELEASE 48%5605544 CTLA4 INHIBITORY SIGNALING 0.0620507679949253 0.160874021995765 1.53436756070465 0.35 11.1 11 1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%REACT_225686.1 AUTODEGRADATION OF CDH1 BY CDH1:APC C 0.00155008258857122 0.0112535139993813 1.53088826918378 0.349206349206349 11.1 11 1 METABOLISM%REACTOME%REACT_188937.2 METABOLISM 1.7675298318315e-54 2.51519495069622e-51 1.52545257810533 0.34796642995481 11.1 11 1 FATTY ACIDS%REACTOME DATABASE ID RELEASE 48%5604882 FATTY ACIDS 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%REACT_205561.1 FCERI MEDIATED NF-KB ACTIVATION 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 LAMININ INTERACTIONS%REACTOME%REACT_202342.1 LAMININ INTERACTIONS 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 48%5605652 LYSOSOME VESICLE BIOGENESIS 0.0491060689338002 0.133143678216046 1.52483732740835 0.347826086956522 11.1 11 1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR%REACTOME DATABASE ID RELEASE 48%5604792 DOWNSTREAM SIGNALING OF ACTIVATED FGFR 1.24738015987068e-05 0.00025357456678514 1.51883403084375 0.346456692913386 11.1 11 1 INTEGRIN ALPHAIIB BETA3 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605482 INTEGRIN ALPHAIIB BETA3 SIGNALING 0.039047484059714 0.111351843320587 1.51750637871888 0.346153846153846 11.1 11 1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%REACT_188204.2 FC EPSILON RECEPTOR (FCERI) SIGNALING 1.41995324128528e-06 3.67380629517992e-05 1.51750637871888 0.346153846153846 11.1 11 1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 48%5604635 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A 0.0036165171826506 0.0197263633259533 1.51444070926693 0.345454545454545 11.1 11 1 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5604634 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 0.0036165171826506 0.0197263633259533 1.51444070926693 0.345454545454545 11.1 11 1 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 48%5604633 P53-INDEPENDENT DNA DAMAGE RESPONSE 0.0036165171826506 0.0197263633259533 1.51444070926693 0.345454545454545 11.1 11 1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604658 SLC-MEDIATED TRANSMEMBRANE TRANSPORT 1.02109336123912e-09 4.40307834255536e-08 1.51287781895809 0.345098039215686 11.1 11 1 DEGRADATION OF AXIN%REACTOME%REACT_219129.1 DEGRADATION OF AXIN 0.00294291811658438 0.0172621466246555 1.51169217803414 0.344827586206897 11.1 11 1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%REACT_203517.1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 0.00294291811658438 0.0172621466246555 1.51169217803414 0.344827586206897 11.1 11 1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5605122 PKB-MEDIATED EVENTS 0.0311693062739566 0.0950531281992411 1.51169217803414 0.344827586206897 11.1 11 1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604629 CELL CYCLE CHECKPOINTS 2.81266370008629e-05 0.000470872993555623 1.51042184847276 0.34453781512605 11.1 11 1 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%REACT_199115.2 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION 2.48003896234747e-07 7.3522821737926e-06 1.50921399413572 0.344262295081967 11.1 11 1 REGULATION OF APOPTOSIS%REACTOME%REACT_227606.1 REGULATION OF APOPTOSIS 0.00195325318500654 0.0131107513314354 1.50696813997778 0.34375 11.1 11 1 ER-PHAGOSOME PATHWAY%REACTOME%REACT_199105.2 ER-PHAGOSOME PATHWAY 0.00195325318500654 0.0131107513314354 1.50696813997778 0.34375 11.1 11 1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%REACT_199046.2 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 0.0249602230663966 0.0826009242406567 1.50696813997778 0.34375 11.1 11 1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%REACT_219897.1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN 0.00159293190518968 0.0112683451540708 1.50492340708772 0.343283582089552 11.1 11 1 SIGNALING BY ERBB2%REACTOME%REACT_188191.2 SIGNALING BY ERBB2 7.13926935042855e-06 0.000151629556502385 1.5030539370168 0.342857142857143 11.1 11 1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%REACT_188194.2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS 0.0200418650155204 0.0708794983557263 1.5030539370168 0.342857142857143 11.1 11 1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%REACT_199113.2 ANTIGEN PROCESSING-CROSS PRESENTATION 0.000867047290639302 0.00743258008782968 1.49975776610229 0.342105263157895 11.1 11 1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING%REACTOME%REACT_225836.1 INTERLEUKIN-3, 5 AND GM-CSF SIGNALING 0.0161296892765361 0.0589175779387994 1.49975776610229 0.342105263157895 11.1 11 1 SIGNALING BY SCF-KIT%REACTOME%REACT_188578.2 SIGNALING BY SCF-KIT 2.88467623712712e-05 0.000475265101688338 1.49694396166307 0.341463414634146 11.1 11 1 PI-3K CASCADE%REACTOME%REACT_223993.1 PI-3K CASCADE 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_226735.1 PI3K AKT SIGNALING IN CANCER 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%REACT_188255.2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%REACT_215348.1 PI3K EVENTS IN ERBB2 SIGNALING 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%REACT_203296.1 PI3K EVENTS IN ERBB4 SIGNALING 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 PIP3 ACTIVATES AKT SIGNALING%REACTOME%REACT_226341.1 PIP3 ACTIVATES AKT SIGNALING 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 VISUAL PHOTOTRANSDUCTION%REACTOME%REACT_188260.2 VISUAL PHOTOTRANSDUCTION 0.00047404558284759 0.00478416215880937 1.49568602556084 0.341176470588235 11.1 11 1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%REACT_106572.3 XBP1(S) ACTIVATES CHAPERONE GENES 0.0105070762100659 0.0428411732003548 1.4945138578292 0.340909090909091 11.1 11 1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%REACT_218318.1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION 0.00558594087818059 0.0266738049317147 1.488874182894 0.339622641509434 11.1 11 1 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 48%5604605 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX 0.00299931396499336 0.0172621466246555 1.48487183293998 0.338709677419355 11.1 11 1 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 48%5605533 UNFOLDED PROTEIN RESPONSE (UPR) 0.00299931396499336 0.0172621466246555 1.48487183293998 0.338709677419355 11.1 11 1 GAB1 SIGNALOSOME%REACTOME%REACT_206286.1 GAB1 SIGNALOSOME 0.000482379127075529 0.00480165667930574 1.4777215672918 0.337078651685393 11.1 11 1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 48%5605771 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION 6.95814259537187e-08 2.25032657118504e-06 1.47458700639148 0.336363636363636 11.1 11 1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 48%5604957 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604941 MYD88:MAL CASCADE INITIATED ON PLASMA MEMBRANE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 48%5604958 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604945 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604956 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE 0.00164000455649306 0.0112683451540708 1.46130243876633 0.333333333333333 11.1 11 1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%REACT_225727.1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A 0.00201104816673103 0.0132901687529297 1.46130243876633 0.333333333333333 11.1 11 1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222875.1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00201104816673103 0.0132901687529297 1.46130243876633 0.333333333333333 11.1 11 1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%REACT_206143.1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 0.0251083527910422 0.08289834343771 1.46130243876633 0.333333333333333 11.1 11 1 PKA ACTIVATION%REACTOME%REACT_220108.1 PKA ACTIVATION 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%REACT_199108.2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 BETA-CELLS%REACTOME%REACT_13498.1 BETA-CELLS 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 48%5605540 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1) 0.100462028812074 0.227963870452861 1.46130243876633 0.333333333333333 11.1 11 1 ACTIVATED TLR4 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604942 ACTIVATED TLR4 SIGNALLING 0.000487940460312806 0.00480165667930574 1.46130243876633 0.333333333333333 11.1 11 1 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%REACT_198687.2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS 0.000596487980500153 0.00554772808007659 1.46130243876633 0.333333333333333 11.1 11 1 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER%REACTOME%REACT_196588.2 CONSTITUTIVE PI3K AKT SIGNALING IN CANCER 0.0010926307016358 0.00888464850530139 1.46130243876633 0.333333333333333 11.1 11 1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604750 RNA POLYMERASE I PROMOTER CLEARANCE 0.00246768773993561 0.0149306870149069 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199408.2 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 IN CANCER%REACTOME%REACT_199405.2 SIGNALING BY NOTCH1 IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%REACT_199410.2 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199407.2 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME%REACT_199406.2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%REACT_199409.2 FBXW7 MUTANTS AND NOTCH1 IN CANCER 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH1%REACTOME%REACT_199382.2 SIGNALING BY NOTCH1 0.0045804315967925 0.0226317852855407 1.46130243876633 0.333333333333333 11.1 11 1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME DATABASE ID RELEASE 48%5605470 REGULATION OF ORNITHINE DECARBOXYLASE (ODC) 0.00695028974745303 0.0313976581289704 1.46130243876633 0.333333333333333 11.1 11 1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 48%5604615 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 0.00695028974745303 0.0313976581289704 1.46130243876633 0.333333333333333 11.1 11 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_199054.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00857605737827745 0.0362128476240024 1.46130243876633 0.333333333333333 11.1 11 1 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE%REACTOME%REACT_147847.2 TRANSLOCATION OF GLUT4 TO THE PLASMA MEMBRANE 0.00857605737827745 0.0362128476240024 1.46130243876633 0.333333333333333 11.1 11 1 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 48%5604766 NUCLEOTIDE EXCISION REPAIR 0.00857605737827745 0.0362128476240024 1.46130243876633 0.333333333333333 11.1 11 1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 48%5605535 IRE1ALPHA ACTIVATES CHAPERONES 0.0131106879799278 0.0513953415852264 1.46130243876633 0.333333333333333 11.1 11 1 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 48%5605496 NETRIN-1 SIGNALING 0.0162491461471642 0.0589860585903434 1.46130243876633 0.333333333333333 11.1 11 1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 48%5604795 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA 0.0313238985152917 0.0950531281992411 1.46130243876633 0.333333333333333 11.1 11 1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%REACT_203462.1 FORMATION OF THE EARLY ELONGATION COMPLEX 0.0492154425450738 0.133143678216046 1.46130243876633 0.333333333333333 11.1 11 1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%REACT_198515.2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING 0.0492154425450738 0.133143678216046 1.46130243876633 0.333333333333333 11.1 11 1 SIGNALING BY NOTCH2%REACTOME%REACT_199412.2 SIGNALING BY NOTCH2 0.0492154425450738 0.133143678216046 1.46130243876633 0.333333333333333 11.1 11 1 MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605507 MYOGENESIS 0.0620659438339249 0.160874021995765 1.46130243876633 0.333333333333333 11.1 11 1 CDO IN MYOGENESIS%REACTOME DATABASE ID RELEASE 48%5605506 CDO IN MYOGENESIS 0.0620659438339249 0.160874021995765 1.46130243876633 0.333333333333333 11.1 11 1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 48%5605541 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%REACT_206803.1 CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 48%5605770 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%REACT_213550.1 HSF1-DEPENDENT TRANSACTIVATION 0.0786927050928381 0.192872053532107 1.46130243876633 0.333333333333333 11.1 11 1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%REACT_198565.2 N-GLYCAN ANTENNAE ELONGATION 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605484 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%REACT_204812.1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604602 ASSOCIATION OF LICENSING FACTORS WITH THE PRE-REPLICATIVE COMPLEX 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 48%5605641 MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 48%5605488 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 0.129434468927293 0.279851529173959 1.46130243876633 0.333333333333333 11.1 11 1 ACTIVATION OF GABAB RECEPTORS%REACTOME%REACT_207065.1 ACTIVATION OF GABAB RECEPTORS 0.0201768774917425 0.0708930781993818 1.46130243876633 0.333333333333333 11.1 11 1 GABA B RECEPTOR ACTIVATION%REACTOME%REACT_217868.1 GABA B RECEPTOR ACTIVATION 0.0201768774917425 0.0708930781993818 1.46130243876633 0.333333333333333 11.1 11 1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 48%5604789 DOWNSTREAM SIGNAL TRANSDUCTION 3.05478556829861e-05 0.000493972711782833 1.45078947158096 0.330935251798561 11.1 11 1 PI3K AKT ACTIVATION%REACTOME%REACT_205300.1 PI3K AKT ACTIVATION 0.000897372074753315 0.00764646983457465 1.4446967292349 0.329545454545455 11.1 11 1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 48%5605073 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE 0.00134454159302328 0.0101231888194293 1.44348167731796 0.329268292682927 11.1 11 1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 48%5604947 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE 0.00164709472385575 0.0112683451540708 1.44280493954144 0.329113924050633 11.1 11 1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 48%5604946 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE 0.00164709472385575 0.0112683451540708 1.44280493954144 0.329113924050633 11.1 11 1 REMOVAL OF LICENSING FACTORS FROM ORIGINS%REACTOME DATABASE ID RELEASE 48%5604612 REMOVAL OF LICENSING FACTORS FROM ORIGINS 0.00201890517700959 0.0132901687529297 1.44207477509836 0.328947368421053 11.1 11 1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%REACT_222604.1 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 0.00247620670099651 0.0149306870149069 1.4412845971394 0.328767123287671 11.1 11 1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605138 REGULATION OF INSULIN SECRETION 0.0030391672214637 0.0172621466246555 1.4404266896411 0.328571428571429 11.1 11 1 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 48%5604787 NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 2.9414134180223e-06 6.65558735862135e-05 1.43734666108164 0.327868852459016 11.1 11 1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 48%5604943 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE 0.000402653700862672 0.00436038000557404 1.43320046879006 0.326923076923077 11.1 11 1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%REACT_226335.1 AQUAPORIN-MEDIATED TRANSPORT 0.0130781826923627 0.0513953415852264 1.431479940016 0.326530612244898 11.1 11 1 B CELL ACTIVATION%REACTOME%REACT_188199.2 B CELL ACTIVATION 2.94660578772414e-06 6.65558735862135e-05 1.43004463258951 0.32620320855615 11.1 11 1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%REACT_199101.2 MITOCHONDRIAL PROTEIN IMPORT 0.0161888777048985 0.0589175779387994 1.42953499444533 0.326086956521739 11.1 11 1 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605555 PROTEIN FOLDING 0.0161888777048985 0.0589175779387994 1.42953499444533 0.326086956521739 11.1 11 1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 48%5604812 INSULIN RECEPTOR SIGNALLING CASCADE 0.00134359875195222 0.0101231888194293 1.4273186611206 0.325581395348837 11.1 11 1 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604781 PLC BETA MEDIATED EVENTS 0.0200733927177496 0.0708794983557263 1.4273186611206 0.325581395348837 11.1 11 1 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 48%5605089 SIGNALING BY NOTCH 0.00201515908951138 0.0132901687529297 1.42476987779718 0.325 11.1 11 1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605554 CHAPERONIN-MEDIATED PROTEIN FOLDING 0.024937992017264 0.0826009242406567 1.42476987779718 0.325 11.1 11 1 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604752 RNA POLYMERASE I, RNA POLYMERASE III, AND MITOCHONDRIAL TRANSCRIPTION 0.00026989507639172 0.0030830190110272 1.42284711143038 0.324561403508772 11.1 11 1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 48%5604613 ORC1 REMOVAL FROM CHROMATIN 0.00302940663242548 0.0172621466246555 1.42180777825913 0.324324324324324 11.1 11 1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 48%5604614 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE 0.00302940663242548 0.0172621466246555 1.42180777825913 0.324324324324324 11.1 11 1 DISEASE%REACTOME%REACT_189085.2 DISEASE 6.16571946887112e-21 4.3869094021018e-18 1.420138989787 0.323943661971831 11.1 11 1 CELL-CELL COMMUNICATION%REACTOME%REACT_223082.1 CELL-CELL COMMUNICATION 0.000490452878268958 0.00480165667930574 1.41955094051587 0.323809523809524 11.1 11 1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 48%5604822 PI3K CASCADE 0.00456653939593938 0.0226317852855407 1.41832295527321 0.323529411764706 11.1 11 1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%REACT_196650.2 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY 0.0387598159643817 0.110753450034769 1.41832295527321 0.323529411764706 11.1 11 1 S PHASE%REACTOME DATABASE ID RELEASE 48%5604608 S PHASE 0.000148369668579874 0.00193697282925836 1.4152771651044 0.322834645669291 11.1 11 1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 48%5604652 BIOLOGICAL OXIDATIONS 5.26496358160618e-06 0.000113515805706448 1.41416365041903 0.32258064516129 11.1 11 1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 48%5605613 CELL JUNCTION ORGANIZATION 0.00690584738868433 0.0313962326967981 1.41416365041903 0.32258064516129 11.1 11 1 DAG AND IP3 SIGNALING%REACTOME%REACT_188269.2 DAG AND IP3 SIGNALING 0.0485301500598542 0.133060507774899 1.41416365041903 0.32258064516129 11.1 11 1 AUF1 (HNRNP D0) DESTABILIZES MRNA%REACTOME%REACT_198693.2 AUF1 (HNRNP D0) DESTABILIZES MRNA 0.00850436756815827 0.0362128476240024 1.41176676287595 0.322033898305085 11.1 11 1 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 48%5605075 REGULATION OF MITOTIC CELL CYCLE 0.00163503808193985 0.0112683451540708 1.41091269949853 0.32183908045977 11.1 11 1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 48%5605074 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 0.00163503808193985 0.0112683451540708 1.41091269949853 0.32183908045977 11.1 11 1 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 48%5605591 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION 0.0609825688668966 0.159812514728534 1.40911306595325 0.321428571428571 11.1 11 1 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 48%5604813 SIGNALING BY INSULIN RECEPTOR 0.000487361588760247 0.00480165667930574 1.40767666119693 0.321100917431193 11.1 11 1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 48%5604953 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME 0.00245126341832529 0.014906614719132 1.40718012621943 0.320987654320988 11.1 11 1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 48%5604955 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE 0.00245126341832529 0.014906614719132 1.40718012621943 0.320987654320988 11.1 11 1 IRS-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604815 IRS-RELATED EVENTS 0.00245126341832529 0.014906614719132 1.40718012621943 0.320987654320988 11.1 11 1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604818 IRS-MEDIATED SIGNALLING 0.00300385158060397 0.0172621466246555 1.40509849881378 0.320512820512821 11.1 11 1 METABOLISM OF LIPIDS AND LIPOPROTEINS%REACTOME DATABASE ID RELEASE 48%5604683 METABOLISM OF LIPIDS AND LIPOPROTEINS 5.11569277044842e-15 1.45592616246962e-12 1.40500006809583 0.320490367775832 11.1 11 1 CA2+ PATHWAY%REACTOME%REACT_221970.1 CA2+ PATHWAY 0.0159918292000766 0.0586504457518272 1.40285034121568 0.32 11.1 11 1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%REACT_199114.2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES) 0.0159918292000766 0.0586504457518272 1.40285034121568 0.32 11.1 11 1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%REACT_210793.1 INTERLEUKIN RECEPTOR SHC SIGNALING 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208267.1 G PROTEIN GATED POTASSIUM CHANNELS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%REACT_196489.2 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%REACT_226457.1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%REACT_208837.1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS 0.0769658195806292 0.190473671762149 1.40285034121568 0.32 11.1 11 1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL%REACTOME%REACT_203664.1 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 0.000266470198273595 0.00308282188734411 1.4014129945546 0.319672131147541 11.1 11 1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%REACT_226135.1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 0.00451925885515973 0.0226317852855407 1.40041483715107 0.319444444444444 11.1 11 1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604751 RNA POLYMERASE I TRANSCRIPTION 0.00451925885515973 0.0226317852855407 1.40041483715107 0.319444444444444 11.1 11 1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604782 G-PROTEIN MEDIATED EVENTS 0.0245376737546685 0.0815820321329283 1.39487960064059 0.318181818181818 11.1 11 1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%REACT_203270.1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A 0.0976660743483841 0.224159393222178 1.39487960064059 0.318181818181818 11.1 11 1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%REACT_188219.2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 MYD88-INDEPENDENT CASCADE%REACTOME DATABASE ID RELEASE 48%5604950 MYD88-INDEPENDENT CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TRIF-MEDIATED TLR3 TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604949 TRIF-MEDIATED TLR3 TLR4 SIGNALING 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 48%5604954 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 IGF1R SIGNALING CASCADE%REACTOME%REACT_188218.2 IGF1R SIGNALING CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 48%5604951 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE 0.00242195408855579 0.014906614719132 1.39253526517733 0.317647058823529 11.1 11 1 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 48%5604659 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 1.11064400484076e-12 5.85350525514221e-11 1.39045141143221 0.317171717171717 11.1 11 1 TOLL-LIKE RECEPTORS CASCADES%REACTOME DATABASE ID RELEASE 48%5604944 TOLL-LIKE RECEPTORS CASCADES 0.000321060576494684 0.00359739527836169 1.39001939297285 0.317073170731707 11.1 11 1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188215.2 IRS-RELATED EVENTS TRIGGERED BY IGF1R 0.00296509855150122 0.0172621466246555 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 48%5604840 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 48%5604860 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 48%5604859 RNA POLYMERASE II PROMOTER ESCAPE 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 48%5604862 RNA POLYMERASE II TRANSCRIPTION INITIATION 0.0304773834049518 0.0938729796217453 1.39001939297285 0.317073170731707 11.1 11 1 DEGRADATION OF DVL%REACTOME%REACT_227429.1 DEGRADATION OF DVL 0.0103227769207424 0.0426374670863918 1.38823731682802 0.316666666666667 11.1 11 1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%REACT_209507.1 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR) 5.36181754500443e-05 0.000794777746514719 1.38731244186677 0.316455696202532 11.1 11 1 REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604603 REGULATION OF DNA REPLICATION 0.00363197975502444 0.0197263633259533 1.38731244186677 0.316455696202532 11.1 11 1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 48%5604952 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 0.00363197975502444 0.0197263633259533 1.38731244186677 0.316455696202532 11.1 11 1 SIGNALING BY NODAL%REACTOME%REACT_220645.1 SIGNALING BY NODAL 0.124792589243113 0.272780114428494 1.38439178409442 0.315789473684211 11.1 11 1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605502 OTHER SEMAPHORIN INTERACTIONS 0.124792589243113 0.272780114428494 1.38439178409442 0.315789473684211 11.1 11 1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%REACT_213852.1 PKA-MEDIATED PHOSPHORYLATION OF CREB 0.124792589243113 0.272780114428494 1.38439178409442 0.315789473684211 11.1 11 1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 48%5604770 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS 0.0156917858760054 0.0583099979382756 1.38011896994598 0.314814814814815 11.1 11 1 DAP12 SIGNALING%REACTOME%REACT_188185.2 DAP12 SIGNALING 0.000142307230843195 0.00187502953231358 1.3795512533808 0.314685314685315 11.1 11 1 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES%REACTOME DATABASE ID RELEASE 48%5604948 TRAF6 MEDIATED INDUCTION OF PROINFLAMMATORY CYTOKINES 0.00822730156492727 0.0352634039966612 1.37406050212357 0.313432835820896 11.1 11 1 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%REACT_196550.2 MHC CLASS II ANTIGEN PRESENTATION 0.00356723688657818 0.0197263633259533 1.37327217137077 0.313253012048193 11.1 11 1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%REACT_210399.1 GLUCAGON SIGNALING IN METABOLIC REGULATION 0.0592437532386985 0.15699042990441 1.36997103634344 0.3125 11.1 11 1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%REACT_203336.1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%REACT_218396.1 BETA-CATENIN PHOSPHORYLATION CASCADE 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604672 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII%REACTOME%REACT_198248.2 CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%REACT_198608.2 G1 S-SPECIFIC TRANSCRIPTION 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 KSRP DESTABILIZES MRNA%REACTOME%REACT_198696.2 KSRP DESTABILIZES MRNA 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%REACT_196581.2 SCAVENGING BY CLASS A RECEPTORS 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605677 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%REACT_202271.1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%REACT_196549.2 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION) 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605651 UNBLOCKING OF NMDA RECEPTOR, GLUTAMATE BINDING AND ACTIVATION 0.160914031182186 0.322962858070875 1.36997103634344 0.3125 11.1 11 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_13641.1 REGULATION OF BETA-CELL DEVELOPMENT 0.0743985370337196 0.188044614918265 1.36052296023072 0.310344827586207 11.1 11 1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%REACT_226355.1 BETA-CATENIN INDEPENDENT WNT SIGNALING 0.000451857535999705 0.00478416215880937 1.35935110582915 0.310077519379845 11.1 11 1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604595 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX 0.00803784867621857 0.0345554642485167 1.358393816318 0.309859154929577 11.1 11 1 CELLULAR RESPONSES TO STRESS%REACTOME%REACT_188957.2 CELLULAR RESPONSES TO STRESS 1.01525789375335e-05 0.000212457644531033 1.35692369314017 0.30952380952381 11.1 11 1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 48%5604596 DNA REPLICATION PRE-INITIATION 0.00426913963034882 0.0225835899404698 1.35692369314017 0.30952380952381 11.1 11 1 M G1 TRANSITION%REACTOME DATABASE ID RELEASE 48%5604597 M G1 TRANSITION 0.00426913963034882 0.0225835899404698 1.35692369314017 0.30952380952381 11.1 11 1 CELLULAR SENESCENCE%REACTOME%REACT_188820.2 CELLULAR SENESCENCE 0.000537096648535295 0.00509754886214448 1.34889455886123 0.307692307692308 11.1 11 1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 48%5604816 INSULIN RECEPTOR RECYCLING 0.0938184131454805 0.219578292608584 1.34889455886123 0.307692307692308 11.1 11 1 NOD1 2 SIGNALING PATHWAY%REACTOME%REACT_211125.1 NOD1 2 SIGNALING PATHWAY 0.0938184131454805 0.219578292608584 1.34889455886123 0.307692307692308 11.1 11 1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 48%5605557 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC 0.0938184131454805 0.219578292608584 1.34889455886123 0.307692307692308 11.1 11 1 DEVELOPMENTAL BIOLOGY%REACTOME%REACT_188576.2 DEVELOPMENTAL BIOLOGY 8.0405090200095e-09 3.09233630688474e-07 1.34799289137536 0.307486631016043 11.1 11 1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604643 CARBOHYDRATE METABOLISM 2.82713650339585e-06 6.5951069579218e-05 1.33952723553581 0.305555555555556 11.1 11 1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%REACT_203841.1 MYOCLONIC EPILEPSY OF LAFORA 2.82713650339585e-06 6.5951069579218e-05 1.33952723553581 0.305555555555556 11.1 11 1 GLYCOGEN STORAGE DISEASES%REACTOME%REACT_203949.1 GLYCOGEN STORAGE DISEASES 2.82713650339585e-06 6.5951069579218e-05 1.33952723553581 0.305555555555556 11.1 11 1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604716 NUCLEOTIDE METABOLISM 0.00759459184709866 0.033378863715354 1.3318199441921 0.30379746835443 11.1 11 1 DAP12 INTERACTIONS%REACTOME%REACT_188188.2 DAP12 INTERACTIONS 0.000270820362880112 0.0030830190110272 1.32931383139389 0.303225806451613 11.1 11 1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 48%5604786 PLC-GAMMA1 SIGNALLING 0.071382820509745 0.181065514412419 1.32845676251485 0.303030303030303 11.1 11 1 PCP CE PATHWAY%REACTOME%REACT_214043.1 PCP CE PATHWAY 0.00602249670556464 0.0283651506814396 1.32536732818342 0.302325581395349 11.1 11 1 HEXOSE UPTAKE%REACTOME DATABASE ID RELEASE 48%5604657 HEXOSE UPTAKE 0.0441278306649272 0.123367196534757 1.32536732818342 0.302325581395349 11.1 11 1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME%REACT_196648.2 NUCLEAR ENVELOPE BREAKDOWN 0.0441278306649272 0.123367196534757 1.32536732818342 0.302325581395349 11.1 11 1 GABA RECEPTOR ACTIVATION%REACTOME%REACT_224131.1 GABA RECEPTOR ACTIVATION 0.0277706023038263 0.0870430992915085 1.323443718128 0.30188679245283 11.1 11 1 PHOSPHOLIPASE C-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604791 PHOSPHOLIPASE C-MEDIATED CASCADE 0.0277706023038263 0.0870430992915085 1.323443718128 0.30188679245283 11.1 11 1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%REACT_209368.1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS 0.0113662877608377 0.0462120785247773 1.32117754737778 0.301369863013699 11.1 11 1 DUAL INCISION REACTION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604767 DUAL INCISION REACTION IN GG-NER 0.151681941206622 0.318353100792069 1.3151721948897 0.3 11.1 11 1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604764 FORMATION OF INCISION COMPLEX IN GG-NER 0.151681941206622 0.318353100792069 1.3151721948897 0.3 11.1 11 1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 48%5604607 SYNTHESIS OF DNA 0.00379722868167232 0.0203904015623386 1.3151721948897 0.3 11.1 11 1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%REACT_199121.2 ACTIVATION OF NF-KAPPAB IN B CELLS 0.0139150489692811 0.053516526171046 1.3151721948897 0.3 11.1 11 1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%REACT_203973.1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS 0.0217266483113375 0.0745415976066133 1.3151721948897 0.3 11.1 11 1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 48%5604600 DNA REPLICATION 0.00301883050444794 0.0172621466246555 1.3110750852483 0.299065420560748 11.1 11 1 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 48%5605642 DEADENYLATION-DEPENDENT MRNA DECAY 0.04231835353849 0.119719715875291 1.3058447325146 0.297872340425532 11.1 11 1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%REACT_188819.2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 0.04231835353849 0.119719715875291 1.3058447325146 0.297872340425532 11.1 11 1 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%REACT_189162.2 THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT 0.000828702113517645 0.00722542437893509 1.3058447325146 0.297872340425532 11.1 11 1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 48%5604670 TRANSMISSION ACROSS CHEMICAL SYNAPSES 0.000279981557604057 0.00316201394024264 1.29987949494912 0.296511627906977 11.1 11 1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 48%5605553 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 0.11259861129302 0.251140789764839 1.29893550112563 0.296296296296296 11.1 11 1 SHC-MEDIATED CASCADE%REACTOME%REACT_94437.3 SHC-MEDIATED CASCADE 0.11259861129302 0.251140789764839 1.29893550112563 0.296296296296296 11.1 11 1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 48%5604923 AXON GUIDANCE 4.22264012075135e-05 0.000660309548552656 1.29747929540688 0.295964125560538 11.1 11 1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 48%5605080 G2 M TRANSITION 0.00541981157979879 0.0259676494210562 1.2972786956395 0.295918367346939 11.1 11 1 SEPARATION OF SISTER CHROMATIDS%REACTOME%REACT_207679.1 SEPARATION OF SISTER CHROMATIDS 0.000492650650160673 0.00480165667930574 1.29096657167087 0.294478527607362 11.1 11 1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%REACT_196607.2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS 0.0849757390703132 0.204949960503484 1.28938450479382 0.294117647058824 11.1 11 1 GLOBAL GENOMIC NER (GG-NER)%REACTOME DATABASE ID RELEASE 48%5604765 GLOBAL GENOMIC NER (GG-NER) 0.0849757390703132 0.204949960503484 1.28938450479382 0.294117647058824 11.1 11 1 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR%REACTOME%REACT_198244.2 RAS ACTIVATION UOPN CA2+ INFUX THROUGH NMDA RECEPTOR 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 48%5605660 ZINC TRANSPORTERS 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 48%5605071 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 SHC-RELATED EVENTS%REACTOME DATABASE ID RELEASE 48%5604824 SHC-RELATED EVENTS 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 48%5604829 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%REACT_202316.1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%REACT_198685.2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 48%5605072 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%REACT_188220.2 SHC-RELATED EVENTS TRIGGERED BY IGF1R 0.195093327040866 0.362425332087666 1.28938450479382 0.294117647058824 11.1 11 1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%REACT_196635.2 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 0.0157169123584993 0.0583099979382756 1.28594614611437 0.293333333333333 11.1 11 1 GLUCOSE TRANSPORT%REACTOME DATABASE ID RELEASE 48%5604656 GLUCOSE TRANSPORT 0.0648408298115023 0.167553946072172 1.28309482428263 0.292682926829268 11.1 11 1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604808 ADAPTIVE IMMUNE SYSTEM 1.21613445217964e-09 5.08988036897536e-08 1.28069202498622 0.292134831460674 11.1 11 1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%REACT_198988.2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 0.049872274373291 0.134470181922374 1.27863963392054 0.291666666666667 11.1 11 1 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%REACT_202898.1 TRAF6 MEDIATED NF-KB ACTIVATION 0.142317896139816 0.30091882051554 1.27863963392054 0.291666666666667 11.1 11 1 APOPTOSIS%REACTOME DATABASE ID RELEASE 48%5604708 APOPTOSIS 0.00100359717155416 0.00825502182151192 1.27274728537713 0.290322580645161 11.1 11 1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%REACT_204192.1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 0.106240918105082 0.238455562245318 1.27274728537713 0.290322580645161 11.1 11 1 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 48%5605109 BILE ACID AND BILE SALT METABOLISM 0.106240918105082 0.238455562245318 1.27274728537713 0.290322580645161 11.1 11 1 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 48%5605081 MITOTIC G2-G2 M PHASES 0.00736587887365294 0.0330455156581383 1.27133312172671 0.29 11.1 11 1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%REACT_188641.2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS 0.0143945549974234 0.0540460468636767 1.2676358504961 0.289156626506024 11.1 11 1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 48%5604926 SIGNALING BY INTERLEUKINS 0.00705160766188766 0.0317545496926143 1.2645886489324 0.288461538461538 11.1 11 1 MITOTIC METAPHASE AND ANAPHASE%REACTOME%REACT_199403.2 MITOTIC METAPHASE AND ANAPHASE 0.000736987394667267 0.00672264783725334 1.26359681469795 0.288235294117647 11.1 11 1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 48%5605526 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATIONåÊFROM THE CENTROSOME 0.0367424110495933 0.106776033520023 1.2631597352048 0.288135593220339 11.1 11 1 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 48%5605525 LOSS OF NLP FROM MITOTIC CENTROSOMES 0.0367424110495933 0.106776033520023 1.2631597352048 0.288135593220339 11.1 11 1 RNA POLYMERASE I CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5604830 RNA POLYMERASE I CHAIN ELONGATION 0.0583093017266164 0.154802493203312 1.252544947514 0.285714285714286 11.1 11 1 TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604734 TRANSCRIPTION 0.000263562305521321 0.00307417344882656 1.252544947514 0.285714285714286 11.1 11 1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 48%5604637 G2 M CHECKPOINTS 0.0760349382451397 0.190282824211907 1.252544947514 0.285714285714286 11.1 11 1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 48%5604636 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 0.100030483972061 0.227963870452861 1.252544947514 0.285714285714286 11.1 11 1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5605524 MITOCHONDRIAL TRNA AMINOACYLATION 0.180877635652135 0.350188946303386 1.252544947514 0.285714285714286 11.1 11 1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 48%5604609 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX 0.133245028263469 0.282996530177488 1.252544947514 0.285714285714286 11.1 11 1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 48%5604780 CA-DEPENDENT EVENTS 0.133245028263469 0.282996530177488 1.252544947514 0.285714285714286 11.1 11 1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%REACT_216784.1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 0.133245028263469 0.282996530177488 1.252544947514 0.285714285714286 11.1 11 1 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 48%5604598 CELL CYCLE, MITOTIC 4.31261350419817e-07 1.2273698032948e-05 1.24519433162483 0.284037558685446 11.1 11 1 MITOTIC ANAPHASE%REACTOME%REACT_202512.1 MITOTIC ANAPHASE 0.00117229071912247 0.00926760940728484 1.24513343894883 0.284023668639053 11.1 11 1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 48%5605529 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 0.0331704346630238 0.0995812838090357 1.24319759715942 0.283582089552239 11.1 11 1 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 48%5605527 CENTROSOME MATURATION 0.0331704346630238 0.0995812838090357 1.24319759715942 0.283582089552239 11.1 11 1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%REACT_198374.2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION 0.0551746307196358 0.146754204699144 1.240728485745 0.283018867924528 11.1 11 1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES%REACTOME%REACT_27166.1 TRANSCRIPTIONAL REGULATION OF ADIPOCYTE DIFFERENTIATION IN 3T3-L1 PRE-ADIPOCYTES 0.0717589021961791 0.181695583318795 1.23893032851928 0.282608695652174 11.1 11 1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%REACT_216309.1 INTEGRIN CELL SURFACE INTERACTIONS 0.0404260074133453 0.115052417098381 1.23297393270909 0.28125 11.1 11 1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%REACT_199008.2 GLYCOSPHINGOLIPID METABOLISM 0.124631113052797 0.272780114428494 1.23297393270909 0.28125 11.1 11 1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%REACT_224879.1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION 0.000778332299105157 0.0070151250602689 1.23297393270909 0.28125 11.1 11 1 SIGNALING BY ERBB4%REACTOME%REACT_188579.2 SIGNALING BY ERBB4 0.00242522594368132 0.014906614719132 1.2286109676252 0.280254777070064 11.1 11 1 M PHASE%REACTOME DATABASE ID RELEASE 48%5605078 M PHASE 0.000128604481097823 0.00172645449624719 1.22615032218325 0.279693486590038 11.1 11 1 APOPTOTIC EXECUTION PHASE%REACTOME%REACT_207035.1 APOPTOTIC EXECUTION PHASE 0.0883860766632865 0.212701824152625 1.22341599524623 0.27906976744186 11.1 11 1 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 48%5604724 GENE EXPRESSION 6.30196951085085e-12 3.20275093355027e-10 1.21995610838185 0.278280542986425 11.1 11 1 L1CAM INTERACTIONS%REACTOME%REACT_219680.1 L1CAM INTERACTIONS 0.0361947370831496 0.1061961048852 1.21775203230528 0.277777777777778 11.1 11 1 FRS2-MEDIATED CASCADE%REACTOME DATABASE ID RELEASE 48%5604921 FRS2-MEDIATED CASCADE 0.116534398043278 0.25951243883503 1.21775203230528 0.277777777777778 11.1 11 1 SYNDECAN INTERACTIONS%REACTOME%REACT_196644.2 SYNDECAN INTERACTIONS 0.231489980205786 0.408207041496627 1.21775203230528 0.277777777777778 11.1 11 1 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 48%5605070 MITOTIC SPINDLE CHECKPOINT 0.231489980205786 0.408207041496627 1.21775203230528 0.277777777777778 11.1 11 1 CELL CYCLE%REACTOME%REACT_188804.2 CELL CYCLE 1.38632196933781e-07 4.2885568747124e-06 1.21682598513242 0.277566539923954 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 48%5604733 RNA POLYMERASE II TRANSCRIPTION 0.0117122960870041 0.0474831832815008 1.21340291790419 0.276785714285714 11.1 11 1 MITOTIC M-M G1 PHASES%REACTOME DATABASE ID RELEASE 48%5604601 MITOTIC M-M G1 PHASES 8.79828710936569e-05 0.00123960025313142 1.21193342191201 0.276450511945392 11.1 11 1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 48%5605576 G ALPHA (Z) SIGNALLING EVENTS 0.155662739208136 0.322962858070875 1.20935374242731 0.275862068965517 11.1 11 1 SIGNALING BY FGFR MUTANTS%REACTOME%REACT_196455.2 SIGNALING BY FGFR MUTANTS 0.108963127231752 0.244180362284698 1.20557451198222 0.275 11.1 11 1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%REACT_188970.2 OXIDATIVE STRESS INDUCED SENESCENCE 0.041423341139843 0.117655517848297 1.20107049761616 0.273972602739726 11.1 11 1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 48%5605128 ASPARAGINE N-LINKED GLYCOSYLATION 0.0159913044488425 0.0586504457518272 1.19561108626336 0.272727272727273 11.1 11 1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 48%5604673 NEUROTRANSMITTER RELEASE CYCLE 0.144599222756442 0.304836583677654 1.19561108626336 0.272727272727273 11.1 11 1 SIALIC ACID METABOLISM%REACTOME%REACT_202500.1 SIALIC ACID METABOLISM 0.144599222756442 0.304836583677654 1.19561108626336 0.272727272727273 11.1 11 1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%REACT_210240.1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 0.212081971141042 0.388407522437198 1.19561108626336 0.272727272727273 11.1 11 1 FGFR LIGAND BINDING AND ACTIVATION%REACTOME%REACT_227330.1 FGFR LIGAND BINDING AND ACTIVATION 0.212081971141042 0.388407522437198 1.19561108626336 0.272727272727273 11.1 11 1 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605136 RESPIRATORY ELECTRON TRANSPORT 0.0368520480635182 0.106776033520023 1.19069087603183 0.271604938271605 11.1 11 1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS%REACTOME%REACT_219118.1 RIG-I MDA5 MEDIATED INDUCTION OF IFN-ALPHA BETA PATHWAYS 0.0501202244779117 0.134822456393324 1.1899177001383 0.271428571428571 11.1 11 1 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 48%5605509 MITOTIC PROMETAPHASE 0.0191656581860406 0.0683527107737739 1.18816179600627 0.271028037383178 11.1 11 1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%REACT_198651.2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM 0.0953259541794689 0.222375135733417 1.18730823149765 0.270833333333333 11.1 11 1 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604802 INNATE IMMUNE SYSTEM 2.26854939250638e-06 5.56576859575272e-05 1.1850806363166 0.270325203252033 11.1 11 1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 48%5604911 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES 0.134454547422541 0.285139822626342 1.18483981521595 0.27027027027027 11.1 11 1 SNRNP ASSEMBLY%REACTOME%REACT_206812.1 SNRNP ASSEMBLY 0.0892044252274748 0.213268062505894 1.18028273900358 0.269230769230769 11.1 11 1 NON-CODING RNA METABOLISM%REACTOME%REACT_224866.1 NON-CODING RNA METABOLISM 0.0892044252274748 0.213268062505894 1.18028273900358 0.269230769230769 11.1 11 1 CD28 CO-STIMULATION%REACTOME%REACT_204081.1 CD28 CO-STIMULATION 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%REACT_205507.1 REGULATION OF BETA-CELL DEVELOPMENT 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 48%5604779 CAM PATHWAY 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 CALMODULIN INDUCED EVENTS%REACTOME%REACT_215587.1 CALMODULIN INDUCED EVENTS 0.19496413237098 0.362425332087666 1.18028273900358 0.269230769230769 11.1 11 1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%REACT_206033.1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) 0.0606140112745146 0.159139738087886 1.17776614467734 0.26865671641791 11.1 11 1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%REACT_205737.1 EPIGENETIC REGULATION OF GENE EXPRESSION 0.021671433558727 0.0745415976066133 1.1771602978951 0.268518518518519 11.1 11 1 INTERLEUKIN-1 SIGNALING%REACTOME%REACT_224208.1 INTERLEUKIN-1 SIGNALING 0.12514130295251 0.273122813038991 1.17617025559241 0.268292682926829 11.1 11 1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%REACT_225233.1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 0.037055157025703 0.106956366019423 1.16904195101307 0.266666666666667 11.1 11 1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%REACT_219771.1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX 0.179726942921939 0.348435204057111 1.16904195101307 0.266666666666667 11.1 11 1 SIGNALING BY WNT%REACTOME%REACT_214014.1 SIGNALING BY WNT 0.000951692060632881 0.007924180012876 1.16342155701781 0.265384615384615 11.1 11 1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%REACT_188530.2 FCERI MEDIATED MAPK ACTIVATION 0.166063676883448 0.332829031274854 1.16044605431444 0.264705882352941 11.1 11 1 MUS MUSCULUS BIOLOGICAL PROCESSES%REACTOME%REACT_200794.1 MUS MUSCULUS BIOLOGICAL PROCESSES 0.00228287163974956 0.0145666392542034 1.15986785498494 0.26457399103139 11.1 11 1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%REACT_221180.1 MPS IIIB - SANFILIPPO SYNDROME B 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%REACT_227993.1 MPS IIID - SANFILIPPO SYNDROME D 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%REACT_222247.1 GLYCOSAMINOGLYCAN METABOLISM 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS II - HUNTER SYNDROME%REACTOME%REACT_215504.1 MPS II - HUNTER SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS I - HURLER SYNDROME%REACTOME%REACT_224474.1 MPS I - HURLER SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IX - NATOWICZ SYNDROME%REACTOME%REACT_219946.1 MPS IX - NATOWICZ SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS VII - SLY SYNDROME%REACTOME%REACT_208416.1 MPS VII - SLY SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%REACT_218935.1 MPS IIIC - SANFILIPPO SYNDROME C 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%REACT_215179.1 MPS VI - MAROTEAUX-LAMY SYNDROME 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MUCOPOLYSACCHARIDOSES%REACTOME%REACT_217438.1 MUCOPOLYSACCHARIDOSES 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IV - MORQUIO SYNDROME B%REACTOME%REACT_211754.1 MPS IV - MORQUIO SYNDROME B 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%REACT_221189.1 MPS IIIA - SANFILIPPO SYNDROME A 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 MPS IV - MORQUIO SYNDROME A%REACTOME%REACT_225132.1 MPS IV - MORQUIO SYNDROME A 0.0274469270236913 0.0864092414927272 1.15575738338792 0.263636363636364 11.1 11 1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%REACT_198984.2 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 0.0947024559795959 0.221283406993374 1.15365982007868 0.263157894736842 11.1 11 1 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 48%5604925 INTERLEUKIN-2 SIGNALING 0.153738601109369 0.321720631439164 1.15365982007868 0.263157894736842 11.1 11 1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 48%5605929 MITOTIC PROPHASE 0.0369176447588554 0.106776033520023 1.15132919417954 0.262626262626263 11.1 11 1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%REACT_198961.2 RESOLUTION OF SISTER CHROMATID COHESION 0.0369176447588554 0.106776033520023 1.15132919417954 0.262626262626263 11.1 11 1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 48%5605146 CLASS B 2 (SECRETIN FAMILY RECEPTORS) 0.0884887420227364 0.212701824152625 1.14987732886531 0.262295081967213 11.1 11 1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604725 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA 0.00968515223451576 0.0406547835684836 1.14943911341986 0.26219512195122 11.1 11 1 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME DATABASE ID RELEASE 48%5605137 RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS. 0.0326739964258205 0.0985065612583528 1.14719069959226 0.261682242990654 11.1 11 1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 48%5605472 PLATELET DEGRANULATION 0.0498947688369738 0.134470181922374 1.14579395766906 0.261363636363636 11.1 11 1 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605135 CHROMOSOME MAINTENANCE 0.0773976675335645 0.191209862674067 1.14362799555626 0.260869565217391 11.1 11 1 INOSITOL PHOSPHATE METABOLISM%REACTOME%REACT_196476.2 INOSITOL PHOSPHATE METABOLISM 0.132397130459008 0.282460444742381 1.14362799555626 0.260869565217391 11.1 11 1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 48%5605153 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 0.244965816231787 0.426666287023052 1.14362799555626 0.260869565217391 11.1 11 1 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 48%5605116 PTM: GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 0.244965816231787 0.426666287023052 1.14362799555626 0.260869565217391 11.1 11 1 ISG15 ANTIVIRAL MECHANISM%REACTOME%REACT_198533.2 ISG15 ANTIVIRAL MECHANISM 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%REACT_196473.2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%REACT_198535.2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 SIGNALING BY FGFR1 MUTANTS%REACTOME%REACT_196452.2 SIGNALING BY FGFR1 MUTANTS 0.223792064748267 0.402447449017216 1.13656856348493 0.259259259259259 11.1 11 1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%REACT_206166.1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+ 0.0524007403059189 0.140691044255326 1.13133092033523 0.258064516129032 11.1 11 1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188266.2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE 0.205287299379977 0.379381593529489 1.13133092033523 0.258064516129032 11.1 11 1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%REACT_214393.1 INWARDLY RECTIFYING K+ CHANNELS 0.205287299379977 0.379381593529489 1.13133092033523 0.258064516129032 11.1 11 1 PHOSPHOLIPID METABOLISM%REACTOME%REACT_188643.2 PHOSPHOLIPID METABOLISM 0.0253116993350044 0.0833762688743316 1.12918824813762 0.257575757575758 11.1 11 1 DOWNSTREAM TCR SIGNALING%REACTOME%REACT_225145.1 DOWNSTREAM TCR SIGNALING 0.188921320583543 0.357018644343136 1.1272904527626 0.257142857142857 11.1 11 1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604803 IMMUNE SYSTEM 2.17766205394838e-08 8.1547713230751e-07 1.11901538103728 0.255255255255255 11.1 11 1 METABOLISM OF RNA%REACTOME%REACT_217867.1 METABOLISM OF RNA 0.00122221091013944 0.00950385860725915 1.11614818175711 0.254601226993865 11.1 11 1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 48%5605635 SPHINGOLIPID METABOLISM 0.119763568248339 0.266286808777166 1.11455270753364 0.254237288135593 11.1 11 1 COLLAGEN FORMATION%REACTOME%REACT_199045.2 COLLAGEN FORMATION 0.111532082411719 0.24954426615075 1.11337328667911 0.253968253968254 11.1 11 1 METABOLISM OF MRNA%REACTOME DATABASE ID RELEASE 48%5605643 METABOLISM OF MRNA 0.0033952722348 0.0190215448429937 1.10784661422718 0.252707581227437 11.1 11 1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%REACT_207809.1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 0.0648785834755915 0.167553946072172 1.10751342727554 0.252631578947368 11.1 11 1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604727 MRNA SPLICING 0.0365919947044107 0.106776033520023 1.1043430644112 0.251908396946565 11.1 11 1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 48%5604726 PRE-MRNA SPLICING 0.0365919947044107 0.106776033520023 1.1043430644112 0.251908396946565 11.1 11 1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 48%5605483 PLATELET AGGREGATION (PLUG FORMATION) 0.213050294763632 0.389679395178211 1.09597682907475 0.25 11.1 11 1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 48%5604922 NCAM SIGNALING FOR NEURITE OUT-GROWTH 0.167328611113122 0.333400684888961 1.09597682907475 0.25 11.1 11 1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%REACT_206758.1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS 0.196100514947882 0.363821424733815 1.09597682907475 0.25 11.1 11 1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%REACT_188265.2 THE PHOTOTRANSDUCTION CASCADE 0.23217269482237 0.408207041496627 1.09597682907475 0.25 11.1 11 1 PACKAGING OF TELOMERE ENDS%REACTOME%REACT_226125.1 PACKAGING OF TELOMERE ENDS 0.279181789595777 0.469170994633351 1.09597682907475 0.25 11.1 11 1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 48%5605481 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION 0.308900941282971 0.501821450295924 1.09597682907475 0.25 11.1 11 1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%REACT_212161.1 ACTIVATION OF BH3-ONLY PROTEINS 0.308900941282971 0.501821450295924 1.09597682907475 0.25 11.1 11 1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%REACT_199384.2 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 0.253974410243199 0.436480176058058 1.09597682907475 0.25 11.1 11 1 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 48%5604671 NEURONAL SYSTEM 0.00778685352329612 0.0340944386573858 1.09157531570497 0.248995983935743 11.1 11 1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%REACT_207044.1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 0.0225767427201987 0.0761296324427553 1.08978486958845 0.248587570621469 11.1 11 1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%REACT_218897.1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA 0.103909259748766 0.233960247820403 1.08244625093802 0.246913580246914 11.1 11 1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%REACT_198517.2 O-LINKED GLYCOSYLATION OF MUCINS 0.201780475155621 0.373871896024021 1.07162178842864 0.244444444444444 11.1 11 1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 48%5605117 POST-TRANSLATIONAL PROTEIN MODIFICATION 0.0230073886694828 0.0773983784318536 1.0646632053869 0.242857142857143 11.1 11 1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 48%5604842 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 0.141555480225346 0.299752155298613 1.0646632053869 0.242857142857143 11.1 11 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604841 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT 0.15222270563936 0.319017540684549 1.06276541001188 0.242424242424242 11.1 11 1 COLLAGEN DEGRADATION%REACTOME%REACT_199055.2 COLLAGEN DEGRADATION 0.260196205883467 0.44555860526134 1.06276541001188 0.242424242424242 11.1 11 1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME%REACT_224460.1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 0.260196205883467 0.44555860526134 1.06276541001188 0.242424242424242 11.1 11 1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%REACT_198521.2 TRAF6 MEDIATED IRF7 ACTIVATION 0.260196205883467 0.44555860526134 1.06276541001188 0.242424242424242 11.1 11 1 HEMOSTASIS%REACTOME%REACT_224553.1 HEMOSTASIS 0.00167453260153005 0.0114012435022835 1.06157396896926 0.242152466367713 11.1 11 1 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%REACT_220092.1 GPVI-MEDIATED ACTIVATION CASCADE 0.314376272864076 0.507783696124381 1.05213775591176 0.24 11.1 11 1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%REACT_219800.1 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 0.314376272864076 0.507783696124381 1.05213775591176 0.24 11.1 11 1 G0 AND EARLY G1%REACTOME%REACT_199110.2 G0 AND EARLY G1 0.314376272864076 0.507783696124381 1.05213775591176 0.24 11.1 11 1 LIPID AND LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 48%5605143 LIPID AND LIPOPROTEIN METABOLISM 0.223586669203128 0.402447449017216 1.04832566259324 0.239130434782609 11.1 11 1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%REACT_222971.1 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1 0.348908224292606 0.528465709519633 1.04378745626167 0.238095238095238 11.1 11 1 SIGNAL TRANSDUCTION BY L1%REACTOME%REACT_215461.1 SIGNAL TRANSDUCTION BY L1 0.348908224292606 0.528465709519633 1.04378745626167 0.238095238095238 11.1 11 1 STIMULI-SENSING CHANNELS%REACTOME%REACT_196640.2 STIMULI-SENSING CHANNELS 0.158493134855475 0.322962858070875 1.03829383807082 0.236842105263158 11.1 11 1 NUCLEOSOME ASSEMBLY%REACTOME%REACT_198595.2 NUCLEOSOME ASSEMBLY 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 48%5605059 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE) 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_224328.1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%REACT_198597.2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE 0.289160060960395 0.482951604162726 1.03150760383506 0.235294117647059 11.1 11 1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 48%5605145 GLUCAGON-TYPE LIGAND RECEPTORS 0.317372751912838 0.51130460627645 1.02291170713643 0.233333333333333 11.1 11 1 LIPOPROTEIN METABOLISM%REACTOME%REACT_211709.1 LIPOPROTEIN METABOLISM 0.317372751912838 0.51130460627645 1.02291170713643 0.233333333333333 11.1 11 1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 48%5604827 SIGNALLING TO RAS 0.350199915012004 0.529017493696478 1.01167091914592 0.230769230769231 11.1 11 1 SYNTHESIS OF PA%REACTOME%REACT_188640.2 SYNTHESIS OF PA 0.350199915012004 0.529017493696478 1.01167091914592 0.230769230769231 11.1 11 1 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 48%5605134 TELOMERE MAINTENANCE 0.269747927754485 0.460253358746561 1.00464542665185 0.229166666666667 11.1 11 1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 48%5604805 MUSCLE CONTRACTION 0.269747927754485 0.460253358746561 1.00464542665185 0.229166666666667 11.1 11 1 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604729 POST-ELONGATION PROCESSING OF INTRON-CONTAINING PRE-MRNA 0.269747927754485 0.460253358746561 1.00464542665185 0.229166666666667 11.1 11 1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%REACT_220175.1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS 0.38915123992542 0.575492029562097 0.996342571886136 0.227272727272727 11.1 11 1 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 48%5604739 METABOLISM OF PROTEINS 0.0102001382221984 0.0426374670863918 0.974959169876761 0.222395023328149 11.1 11 1 O-LINKED GLYCOSYLATION%REACTOME%REACT_204003.1 O-LINKED GLYCOSYLATION 0.294140301923517 0.490693610360099 0.974201625844222 0.222222222222222 11.1 11 1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 48%5604828 SIGNALLING TO ERKS 0.349091895255415 0.528465709519633 0.974201625844222 0.222222222222222 11.1 11 1 REGULATION OF IFNA SIGNALING%REACTOME%REACT_198627.2 REGULATION OF IFNA SIGNALING 0.386316443658788 0.575492029562097 0.974201625844222 0.222222222222222 11.1 11 1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%REACT_198151.2 SPHINGOLIPID DE NOVO BIOSYNTHESIS 0.386316443658788 0.575492029562097 0.974201625844222 0.222222222222222 11.1 11 1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 48%5605604 ION CHANNEL TRANSPORT 0.184243489879753 0.351470989909863 0.966530746900567 0.220472440944882 11.1 11 1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%REACT_225477.1 COSTIMULATION BY THE CD28 FAMILY 0.317634063210388 0.51130460627645 0.956488869010691 0.218181818181818 11.1 11 1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 48%5604836 U12 DEPENDENT SPLICING 0.345776689088681 0.525684004885891 0.953023329630217 0.217391304347826 11.1 11 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_214440.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.270978970306828 0.461800089516905 0.94652544329183 0.215909090909091 11.1 11 1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 48%5604927 CYTOKINE SIGNALING IN IMMUNE SYSTEM 0.146711729449789 0.308832531075517 0.940752642982618 0.214592274678112 11.1 11 1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 48%5604723 TRNA AMINOACYLATION 0.376162854155346 0.566433588849796 0.9394087106355 0.214285714285714 11.1 11 1 INTERFERON ALPHA BETA SIGNALING%REACTOME%REACT_198622.2 INTERFERON ALPHA BETA SIGNALING 0.422409725499402 0.616501578857076 0.9394087106355 0.214285714285714 11.1 11 1 SIGNALING BY ROBO RECEPTOR%REACTOME%REACT_221567.1 SIGNALING BY ROBO RECEPTOR 0.422409725499402 0.616501578857076 0.9394087106355 0.214285714285714 11.1 11 1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%REACT_198649.2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 0.249570036715826 0.433624129727253 0.934275329703066 0.213114754098361 11.1 11 1 NUCLEAR SIGNALING BY ERBB4%REACTOME%REACT_198574.2 NUCLEAR SIGNALING BY ERBB4 0.339267668676279 0.519116013469187 0.934275329703066 0.213114754098361 11.1 11 1 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%REACT_198347.2 LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 0.416156487486931 0.608623516643271 0.929919733760394 0.212121212121212 11.1 11 1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 48%5605603 ION TRANSPORT BY P-TYPE ATPASES 0.416156487486931 0.608623516643271 0.929919733760394 0.212121212121212 11.1 11 1 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE)%REACTOME%REACT_198345.2 PHAGOSOMAL MATURATION (EARLY ENDOSOMAL STAGE) 0.416156487486931 0.608623516643271 0.929919733760394 0.212121212121212 11.1 11 1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 48%5605126 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS 0.369201991908787 0.556540714498097 0.927365009217096 0.211538461538462 11.1 11 1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604902 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT 0.399752913814583 0.587653302022884 0.913314024228958 0.208333333333333 11.1 11 1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 48%5605133 EXTENSION OF TELOMERES 0.468681945694144 0.647509134682298 0.913314024228958 0.208333333333333 11.1 11 1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 48%5605577 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 0.468681945694144 0.647509134682298 0.913314024228958 0.208333333333333 11.1 11 1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%REACT_200667.1 NORC NEGATIVELY REGULATES RRNA EXPRESSION 0.346553138369561 0.526302151440646 0.907015306820483 0.206896551724138 11.1 11 1 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION%REACTOME DATABASE ID RELEASE 48%5604731 CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 0.390234269586196 0.575492029562097 0.907015306820483 0.206896551724138 11.1 11 1 POST-ELONGATION PROCESSING OF THE TRANSCRIPT%REACTOME DATABASE ID RELEASE 48%5604730 POST-ELONGATION PROCESSING OF THE TRANSCRIPT 0.390234269586196 0.575492029562097 0.907015306820483 0.206896551724138 11.1 11 1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 48%5604732 RNA POLYMERASE II TRANSCRIPTION TERMINATION 0.390234269586196 0.575492029562097 0.907015306820483 0.206896551724138 11.1 11 1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 48%5605508 NCAM1 INTERACTIONS 0.458189115677952 0.63756245959007 0.907015306820483 0.206896551724138 11.1 11 1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 48%5604900 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 0.426897065036293 0.622412421666644 0.89467496251 0.204081632653061 11.1 11 1 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 48%5604720 PHASE 1 - FUNCTIONALIZATION OF COMPOUNDS 0.352268722982092 0.531578359282627 0.89301815702387 0.203703703703704 11.1 11 1 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%REACT_206066.1 EXTRACELLULAR MATRIX ORGANIZATION 0.301792022204774 0.499360520462085 0.8767814632598 0.2 11.1 11 1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%REACT_188573.2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK 0.336654548992975 0.516175267245809 0.8767814632598 0.2 11.1 11 1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 48%5604879 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE 0.405343007120819 0.594642370240129 0.8767814632598 0.2 11.1 11 1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 48%5604741 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX 0.446401538626109 0.63756245959007 0.8767814632598 0.2 11.1 11 1 PI METABOLISM%REACTOME%REACT_199016.2 PI METABOLISM 0.453973425993991 0.63756245959007 0.8767814632598 0.2 11.1 11 1 PLATELET HOMEOSTASIS%REACTOME%REACT_208483.1 PLATELET HOMEOSTASIS 0.446401538626109 0.63756245959007 0.8767814632598 0.2 11.1 11 1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%REACT_212343.1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA 0.462241215422425 0.639853355589601 0.8767814632598 0.2 11.1 11 1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%REACT_198580.2 KERATAN SULFATE KERATIN METABOLISM 0.49339320661923 0.679012120908282 0.8767814632598 0.2 11.1 11 1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604897 PROCESSING OF CAPPED INTRONLESS PRE-MRNA 0.507258363901661 0.68968129983539 0.8767814632598 0.2 11.1 11 1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%REACT_196570.2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET) 0.507258363901661 0.68968129983539 0.8767814632598 0.2 11.1 11 1 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 48%5604898 POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA 0.507258363901661 0.68968129983539 0.8767814632598 0.2 11.1 11 1 MEIOSIS%REACTOME%REACT_198624.2 MEIOSIS 0.405162178676087 0.594642370240129 0.86888253115836 0.198198198198198 11.1 11 1 ARACHIDONIC ACID METABOLISM%REACTOME%REACT_188625.2 ARACHIDONIC ACID METABOLISM 0.449399890433916 0.63756245959007 0.864432428566 0.197183098591549 11.1 11 1 POTASSIUM CHANNELS%REACTOME%REACT_202800.1 POTASSIUM CHANNELS 0.439128102073377 0.63756245959007 0.858703494945165 0.195876288659794 11.1 11 1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 48%5604899 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 0.490570424530632 0.67578094298847 0.857720996667196 0.195652173913043 11.1 11 1 ECM PROTEOGLYCANS%REACTOME%REACT_196606.2 ECM PROTEOGLYCANS 0.501385697185597 0.685371611042367 0.855396549521756 0.195121951219512 11.1 11 1 SIGNALING PATHWAYS%REACTOME%REACT_188257.2 SIGNALING PATHWAYS 0.178058391626321 0.345671338723403 0.848981075400343 0.193658536585366 11.1 11 1 CHROMATIN MODIFYING ENZYMES%REACTOME%REACT_202766.1 CHROMATIN MODIFYING ENZYMES 0.447435145207582 0.63756245959007 0.848498190251419 0.193548387096774 11.1 11 1 HATS ACETYLATE HISTONES%REACTOME%REACT_226917.1 HATS ACETYLATE HISTONES 0.447435145207582 0.63756245959007 0.848498190251419 0.193548387096774 11.1 11 1 CHROMATIN ORGANIZATION%REACTOME%REACT_218274.1 CHROMATIN ORGANIZATION 0.447435145207582 0.63756245959007 0.848498190251419 0.193548387096774 11.1 11 1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%REACT_189141.2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES 0.527792134071464 0.709205105555895 0.848498190251419 0.193548387096774 11.1 11 1 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 48%5604618 DNA STRAND ELONGATION 0.527792134071464 0.709205105555895 0.848498190251419 0.193548387096774 11.1 11 1 TCR SIGNALING%REACTOME%REACT_222648.1 TCR SIGNALING 0.507446465866235 0.68968129983539 0.843059099288269 0.192307692307692 11.1 11 1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%REACT_198578.2 KERATAN SULFATE BIOSYNTHESIS 0.544653232684913 0.729794303305679 0.843059099288269 0.192307692307692 11.1 11 1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%REACT_213918.1 WNT LIGAND BIOGENESIS AND TRAFFICKING 0.544653232684913 0.729794303305679 0.843059099288269 0.192307692307692 11.1 11 1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%REACT_196580.2 CONDENSATION OF PROPHASE CHROMOSOMES 0.530849895545655 0.712640944680629 0.835029965009333 0.19047619047619 11.1 11 1 MEIOTIC SYNAPSIS%REACTOME%REACT_75800.2 MEIOTIC SYNAPSIS 0.504225322564807 0.687931576231755 0.830635070456653 0.189473684210526 11.1 11 1 MEIOTIC SYNAPSIS%REACTOME%REACT_198626.2 MEIOTIC SYNAPSIS 0.504225322564807 0.687931576231755 0.830635070456653 0.189473684210526 11.1 11 1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 48%5605127 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN 0.559579245667987 0.733650487873738 0.809336735316739 0.184615384615385 11.1 11 1 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%REACT_196573.2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 0.572671338310615 0.748311583485772 0.805207466259 0.183673469387755 11.1 11 1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%REACT_207651.1 G ALPHA (Q) SIGNALLING EVENTS 0.568707581454841 0.743815154788823 0.801934265176646 0.182926829268293 11.1 11 1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%REACT_198522.2 NONSENSE-MEDIATED DECAY (NMD) 0.57553020445975 0.748483785694245 0.799580579702333 0.182389937106918 11.1 11 1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%REACT_198528.2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC) 0.57553020445975 0.748483785694245 0.799580579702333 0.182389937106918 11.1 11 1 INTERFERON GAMMA SIGNALING%REACTOME%REACT_198660.2 INTERFERON GAMMA SIGNALING 0.584390765738533 0.753932964320881 0.797074057508909 0.181818181818182 11.1 11 1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%REACT_198973.2 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 0.593417989795496 0.762124367760822 0.797074057508909 0.181818181818182 11.1 11 1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 48%5604735 RIBOSOMAL SCANNING AND START CODON RECOGNITION 0.595071750205359 0.763559152878473 0.790540663594902 0.180327868852459 11.1 11 1 INTERFERON SIGNALING%REACTOME%REACT_198666.2 INTERFERON SIGNALING 0.599159846518482 0.768112127563783 0.78910331693382 0.18 11.1 11 1 BASIGIN INTERACTIONS%REACTOME%REACT_211508.1 BASIGIN INTERACTIONS 0.615036505914287 0.786340474318087 0.78284059219625 0.178571428571429 11.1 11 1 PURINE METABOLISM%REACTOME DATABASE ID RELEASE 48%5604715 PURINE METABOLISM 0.624347240403794 0.795191832631422 0.773630702876294 0.176470588235294 11.1 11 1 PRC2 METHYLATES HISTONES AND DNA%REACTOME%REACT_222475.1 PRC2 METHYLATES HISTONES AND DNA 0.632921750581984 0.795191832631422 0.767183780352325 0.175 11.1 11 1 MEIOTIC RECOMBINATION%REACTOME%REACT_27235.2 MEIOTIC RECOMBINATION 0.649573340896672 0.803776403561708 0.764634997028895 0.174418604651163 11.1 11 1 TRANSLATION%REACTOME DATABASE ID RELEASE 48%5604738 TRANSLATION 0.710438849104496 0.854568455009043 0.756613445452619 0.17258883248731 11.1 11 1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%REACT_199052.2 DEGRADATION OF THE EXTRACELLULAR MATRIX 0.679909032449843 0.833724698799764 0.752792165425081 0.171717171717172 11.1 11 1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 48%5605085 EUKARYOTIC TRANSLATION ELONGATION 0.70153664007857 0.853760078035766 0.7515269685084 0.171428571428571 11.1 11 1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%REACT_204001.1 INTRINSIC PATHWAY FOR APOPTOSIS 0.660002702751829 0.815972064305693 0.748471980831537 0.170731707317073 11.1 11 1 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%REACT_198614.2 GROWTH HORMONE RECEPTOR SIGNALING 0.666006829625453 0.822680311247412 0.74619699000834 0.170212765957447 11.1 11 1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 48%5604743 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT 0.724098516937246 0.869325318397789 0.741396090256449 0.169117647058824 11.1 11 1 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 48%5605084 PEPTIDE CHAIN ELONGATION 0.7372673042847 0.882364486120377 0.735984439962606 0.167883211678832 11.1 11 1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604736 CAP-DEPENDENT TRANSLATION INITIATION 0.751817868457501 0.895371216651734 0.735189425714739 0.167701863354037 11.1 11 1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%REACT_215863.1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS 0.678577013332383 0.833724698799764 0.730651219383167 0.166666666666667 11.1 11 1 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%REACT_198998.2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES 0.678577013332383 0.833724698799764 0.730651219383167 0.166666666666667 11.1 11 1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 48%5604737 EUKARYOTIC TRANSLATION INITIATION 0.763269369804609