### SpliceAI update - May 15th, 2020 In the initial CADD GRCh37-v1.6, we noticed a warning for de-novo (aka not prescoed) scored variants on Chromosome X in positions ~180.000-196.609. This was due to a incompatibility for the annotation SpliceAI between tabix index and data file. Actually affected from this bug are therefore only InDel that have not been prescored on Chromosome X between 192.989-196.609. SNV in the same range are also affected if no prescoring is used, i.e in offline scoring. We therefore had to replace data and index file for SpliceAI in the annotations. In order that existing installs do not have to download the entire annotations again, this folder provides only the updated files that are be put into the folder `data/annotations/GRCh37-v1.6/spliceai/` in the CADD scripts directory. Due to the limited nature of this bug (and the CADD score range not being affected), we decided not to issues a new CADD release. When we write henceforce of v1.6, this means the current version with updated SpliceAI. If it should be necessary to address specifically the old version, it may be called v1.6.0.