featured preprints (work led or co-led by our lab)

Hamazaki, Yang et al. Induction and in silico staging of human gastruloids with neural tube, segmented somites & advanced cell types
bioRxiv 2024.02.10.579769
Posted February 12, 2024

Pinglay et al. Multiplex generation and single cell analysis of structural variants in a mammalian genome
bioRxiv 2024.01.22.576756
Posted January 23, 2024

Choi et al. A molecular proximity sensor based on an engineered, dual-component guide RNA
bioRxiv 2023.08.14.553235
Posted August 14, 2023

Chardon et al. A multiplex, prime editing framework for identifying drug resistance variants at scale
bioRxiv 2023.07.27.550902
Posted July 30, 2023

Chardon, McDiarmid et al. Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements
bioRxiv 2023.03.28.534017
Posted March 28, 2023

Agarwal, Inoue et al. Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types
bioRxiv 2023.03.05.531189
Posted March 06, 2023

Lalanne, Regalado et al. Multiplex profiling of developmental enhancers with quantitative, single-cell expression reporters
bioRxiv 2022.12.10.519236
Posted December 10, 2022

Read et al. Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart
bioRxiv 2022.07.12.496461
Posted July 19, 2022

Minkina et al. Tethering distinct molecular profiles of single cells by their lineage histories to investigate sources of cell state heterogeneity
bioRxiv 2022.05.12.491602
Posted May 12, 2022

Chen, Choi et al. Multiplex genomic recording of enhancer and signal transduction activity in mammalian cells
bioRxiv 2022.05.12.491602
Posted November 05, 2021

Bedford et al. Viral genome sequencing places White House COVID-19 outbreak into phylogenetic context
medRxiv 2022.05.12.491602
Posted November 01, 2020

Calderon et al. TransMPRA: A framework for assaying the role of many trans-acting factors at many enhancers
bioRxiv 2020.09.30.321323
Posted October 01, 2020